Gene "Gene synonym" Ensembl "Gene description" Uniprot Chromosome Position "Protein class" "Biological process" "Molecular function" "Disease involvement" Evidence "HPA evidence" "UniProt evidence" "NeXtProt evidence" "MS evidence" "RNA tissue specificity" "RNA tissue distribution" "RNA tissue specificity score" "RNA tissue specific NX" "RNA cell line specificity" "RNA cell line distribution" "RNA cell line specificity score" "RNA cell line specific NX" "RNA cancer specificity" "RNA cancer distribution" "RNA cancer specificity score" "RNA cancer specific FPKM" "RNA brain regional specificity" "RNA brain regional distribution" "RNA brain regional specificity score" "RNA brain regional specific NX" "RNA blood cell specificity" "RNA blood cell distribution" "RNA blood cell specificity score" "RNA blood cell specific NX" "RNA blood lineage specificity" "RNA blood lineage distribution" "RNA blood lineage specificity score" "RNA blood lineage specific NX" "RNA mouse brain regional specificity" "RNA mouse brain regional distribution" "RNA mouse brain regional specificity score" "RNA mouse brain regional specific pTPM" "RNA pig brain regional specificity" "RNA pig brain regional distribution" "RNA pig brain regional specificity score" "RNA pig brain regional specific pTPM" Antibody "Reliability (IH)" "Reliability (Mouse Brain)" "Reliability (IF)" "Subcellular location" "Secretome location" "Blood concentration - Conc. blood IM [pg/L]" "Blood concentration - Conc. blood MS [pg/L]" "Subcellular main location" "Subcellular additional location" "Antibody RRID" "Pathology prognostics - Breast cancer" "Pathology prognostics - Cervical cancer" "Pathology prognostics - Colorectal cancer" "Pathology prognostics - Endometrial cancer" "Pathology prognostics - Glioma" "Pathology prognostics - Head and neck cancer" "Pathology prognostics - Liver cancer" "Pathology prognostics - Lung cancer" "Pathology prognostics - Melanoma" "Pathology prognostics - Ovarian cancer" "Pathology prognostics - Pancreatic cancer" "Pathology prognostics - Prostate cancer" "Pathology prognostics - Renal cancer" "Pathology prognostics - Stomach cancer" "Pathology prognostics - Testis cancer" "Pathology prognostics - Thyroid cancer" "Pathology prognostics - Urothelial cancer" "Tissue RNA - adipose tissue [NX]" "Tissue RNA - adrenal gland [NX]" "Tissue RNA - amygdala [NX]" "Tissue RNA - appendix [NX]" "Tissue RNA - basal ganglia [NX]" "Tissue RNA - bone marrow [NX]" "Tissue RNA - breast [NX]" "Tissue RNA - cerebellum [NX]" "Tissue RNA - cerebral cortex [NX]" "Tissue RNA - cervix, uterine [NX]" "Tissue RNA - colon [NX]" "Tissue RNA - corpus callosum [NX]" "Tissue RNA - ductus deferens [NX]" "Tissue RNA - duodenum [NX]" "Tissue RNA - endometrium 1 [NX]" "Tissue RNA - epididymis [NX]" "Tissue RNA - esophagus [NX]" "Tissue RNA - fallopian tube [NX]" "Tissue RNA - gallbladder [NX]" "Tissue RNA - heart muscle [NX]" "Tissue RNA - hippocampal formation [NX]" "Tissue RNA - hypothalamus [NX]" "Tissue RNA - kidney [NX]" "Tissue RNA - liver [NX]" "Tissue RNA - lung [NX]" "Tissue RNA - lymph node [NX]" "Tissue RNA - midbrain [NX]" "Tissue RNA - olfactory region [NX]" "Tissue RNA - ovary [NX]" "Tissue RNA - pancreas [NX]" "Tissue RNA - parathyroid gland [NX]" "Tissue RNA - pituitary gland [NX]" "Tissue RNA - placenta [NX]" "Tissue RNA - pons and medulla [NX]" "Tissue RNA - prostate [NX]" "Tissue RNA - rectum [NX]" "Tissue RNA - retina [NX]" "Tissue RNA - salivary gland [NX]" "Tissue RNA - seminal vesicle [NX]" "Tissue RNA - skeletal muscle [NX]" "Tissue RNA - skin 1 [NX]" "Tissue RNA - small intestine [NX]" "Tissue RNA - smooth muscle [NX]" "Tissue RNA - spinal cord [NX]" "Tissue RNA - spleen [NX]" "Tissue RNA - stomach 1 [NX]" "Tissue RNA - testis [NX]" "Tissue RNA - thalamus [NX]" "Tissue RNA - thymus [NX]" "Tissue RNA - thyroid gland [NX]" "Tissue RNA - tongue [NX]" "Tissue RNA - tonsil [NX]" "Tissue RNA - urinary bladder [NX]" "Tissue RNA - vagina [NX]" "Tissue RNA - B-cells [NX]" "Tissue RNA - dendritic cells [NX]" "Tissue RNA - granulocytes [NX]" "Tissue RNA - monocytes [NX]" "Tissue RNA - NK-cells [NX]" "Tissue RNA - T-cells [NX]" "Tissue RNA - total PBMC [NX]" "Cell RNA - A-431 [NX]" "Cell RNA - A549 [NX]" "Cell RNA - AF22 [NX]" "Cell RNA - AN3-CA [NX]" "Cell RNA - ASC diff [NX]" "Cell RNA - ASC TERT1 [NX]" "Cell RNA - BEWO [NX]" "Cell RNA - BJ [NX]" "Cell RNA - BJ hTERT+ [NX]" "Cell RNA - BJ hTERT+ SV40 Large T+ [NX]" "Cell RNA - BJ hTERT+ SV40 Large T+ RasG12V [NX]" "Cell RNA - CACO-2 [NX]" "Cell RNA - CAPAN-2 [NX]" "Cell RNA - Daudi [NX]" "Cell RNA - EFO-21 [NX]" "Cell RNA - fHDF/TERT166 [NX]" "Cell RNA - HaCaT [NX]" "Cell RNA - HAP1 [NX]" "Cell RNA - HBEC3-KT [NX]" "Cell RNA - HBF TERT88 [NX]" "Cell RNA - HDLM-2 [NX]" "Cell RNA - HEK 293 [NX]" "Cell RNA - HEL [NX]" "Cell RNA - HeLa [NX]" "Cell RNA - Hep G2 [NX]" "Cell RNA - HHSteC [NX]" "Cell RNA - HL-60 [NX]" "Cell RNA - HMC-1 [NX]" "Cell RNA - HSkMC [NX]" "Cell RNA - hTCEpi [NX]" "Cell RNA - hTEC/SVTERT24-B [NX]" "Cell RNA - hTERT-HME1 [NX]" "Cell RNA - HUVEC TERT2 [NX]" "Cell RNA - K-562 [NX]" "Cell RNA - Karpas-707 [NX]" "Cell RNA - LHCN-M2 [NX]" "Cell RNA - MCF7 [NX]" "Cell RNA - MOLT-4 [NX]" "Cell RNA - NB-4 [NX]" "Cell RNA - NTERA-2 [NX]" "Cell RNA - PC-3 [NX]" "Cell RNA - REH [NX]" "Cell RNA - RH-30 [NX]" "Cell RNA - RPMI-8226 [NX]" "Cell RNA - RPTEC TERT1 [NX]" "Cell RNA - RT4 [NX]" "Cell RNA - SCLC-21H [NX]" "Cell RNA - SH-SY5Y [NX]" "Cell RNA - SiHa [NX]" "Cell RNA - SK-BR-3 [NX]" "Cell RNA - SK-MEL-30 [NX]" "Cell RNA - T-47d [NX]" "Cell RNA - THP-1 [NX]" "Cell RNA - TIME [NX]" "Cell RNA - U-138 MG [NX]" "Cell RNA - U-2 OS [NX]" "Cell RNA - U-2197 [NX]" "Cell RNA - U-251 MG [NX]" "Cell RNA - U-266/70 [NX]" "Cell RNA - U-266/84 [NX]" "Cell RNA - U-698 [NX]" "Cell RNA - U-87 MG [NX]" "Cell RNA - U-937 [NX]" "Cell RNA - WM-115 [NX]" "Blood RNA - basophil [NX]" "Blood RNA - classical monocyte [NX]" "Blood RNA - eosinophil [NX]" "Blood RNA - gdT-cell [NX]" "Blood RNA - intermediate monocyte [NX]" "Blood RNA - MAIT T-cell [NX]" "Blood RNA - memory B-cell [NX]" "Blood RNA - memory CD4 T-cell [NX]" "Blood RNA - memory CD8 T-cell [NX]" "Blood RNA - myeloid DC [NX]" "Blood RNA - naive B-cell [NX]" "Blood RNA - naive CD4 T-cell [NX]" "Blood RNA - naive CD8 T-cell [NX]" "Blood RNA - neutrophil [NX]" "Blood RNA - NK-cell [NX]" "Blood RNA - non-classical monocyte [NX]" "Blood RNA - plasmacytoid DC [NX]" "Blood RNA - T-reg [NX]" "Blood RNA - total PBMC [NX]" "Brain RNA - amygdala [NX]" "Brain RNA - basal ganglia [NX]" "Brain RNA - cerebellum [NX]" "Brain RNA - cerebral cortex [NX]" "Brain RNA - hippocampal formation [NX]" "Brain RNA - hypothalamus [NX]" "Brain RNA - midbrain [NX]" "Brain RNA - olfactory region [NX]" "Brain RNA - pons and medulla [NX]" "Brain RNA - thalamus [NX]" ACLY "ACL, ATPCL, CLATP" ENSG00000131473 "ATP citrate lyase" P53396 17 41866908-41930542 "Cancer-related genes, Citric acid cycle related proteins, Enzymes, Plasma proteins, Predicted intracellular proteins" "Lipid biosynthesis, Lipid metabolism" Transferase "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB007783, HPA022434, HPA022953, HPA022959, HPA028758" Enhanced Supported "Nucleoplasm,Plasma membrane,Cytosol" 2100000 "Plasma membrane, Cytosol" Nucleoplasm "CAB007783: AB_562242, HPA022434: AB_1844513, HPA022953: AB_1844514, HPA022959: AB_1844515, HPA028758: AB_10603575" "unprognostic (2.21e-2)" "prognostic unfavourable (1.79e-4)" "unprognostic (1.41e-1)" "unprognostic (1.21e-2)" "unprognostic (2.83e-1)" "unprognostic (8.94e-3)" "prognostic unfavourable (3.66e-4)" "unprognostic (3.38e-3)" "unprognostic (4.11e-2)" "unprognostic (5.94e-3)" "unprognostic (2.13e-2)" "unprognostic (3.01e-2)" "unprognostic (3.88e-3)" "unprognostic (1.66e-1)" "unprognostic (9.36e-2)" "unprognostic (3.90e-2)" "unprognostic (4.67e-3)" 38.3 24.0 16.7 26.2 22.9 19.1 35.7 21.5 29.1 22.9 22.2 25.1 18.0 30.7 27.0 24.9 23.2 23.7 28.2 18.4 18.3 33.7 37.8 22.2 23.3 27.4 23.1 17.9 19.0 30.6 27.1 19.5 26.7 49.0 41.3 23.2 15.6 25.4 19.6 10.9 19.6 29.6 27.2 26.2 24.5 24.6 20.7 21.4 32.0 21.3 18.2 24.6 20.3 21.3 16.1 23.9 25.2 26.3 16.0 23.9 21.4 23.2 79.1 37.4 32.2 57.8 54.3 34.4 32.7 35.8 41.2 51.8 40.1 26.8 37.8 21.0 45.8 37.0 48.2 56.0 34.5 34.0 46.1 21.6 45.6 41.7 26.9 34.9 28.3 43.1 16.9 72.4 14.6 43.4 26.6 30.2 34.1 23.7 57.4 19.6 24.3 14.4 37.7 45.2 48.4 42.2 41.4 70.4 38.7 23.3 73.0 25.0 43.5 33.4 46.6 32.2 26.5 32.3 53.6 17.7 22.5 35.9 54.4 27.1 26.1 18.9 20.7 25.2 23.8 22.1 22.5 16.1 19.0 21.3 23.9 13.8 14.6 16.1 10.7 16.0 26.3 13.9 23.9 21.4 16.7 22.9 21.5 27.7 18.3 33.7 23.1 17.9 49.0 21.4 ACO1 "IREB1, IREBP, IRP1" ENSG00000122729 "Aconitase 1" P21399 9 32384603-32454769 "Cancer-related genes, Citric acid cycle related proteins, Enzymes, Plasma proteins, Predicted intracellular proteins" "Tricarboxylic acid cycle" "Lyase, RNA-binding" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 80.9" "Cell line enhanced" "Detected in many" "ASC diff: 52.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA019371, HPA024157" Enhanced Supported Mitochondria,Cytosol 8000000 "Mitochondria, Cytosol" "HPA019371: AB_1844519, HPA024157: AB_1844520" "unprognostic (2.11e-1)" "unprognostic (5.61e-2)" "unprognostic (8.38e-2)" "unprognostic (9.12e-2)" "unprognostic (2.63e-1)" "unprognostic (3.12e-2)" "unprognostic (4.25e-3)" "unprognostic (2.61e-2)" "unprognostic (1.37e-1)" "unprognostic (1.19e-1)" "unprognostic (2.55e-1)" "unprognostic (3.08e-1)" "prognostic favourable (5.73e-5)" "unprognostic (2.54e-1)" "unprognostic (6.58e-2)" "unprognostic (1.65e-1)" "unprognostic (3.23e-2)" 41.4 27.2 9.6 7.1 9.4 1.5 30.1 8.9 8.1 9.3 19.7 6.2 6.4 21.9 12.8 14.6 12.8 7.2 8.9 15.1 6.5 7.6 40.5 80.9 9.2 9.4 6.1 6.2 14.1 27.9 8.9 8.7 11.3 7.7 10.7 9.8 11.7 11.7 9.5 11.2 5.5 28.4 14.5 6.0 6.4 13.5 11.4 5.9 6.0 18.4 7.2 5.1 13.9 11.7 4.7 7.1 21.4 8.8 4.7 7.4 6.2 9.4 8.7 6.7 10.6 52.5 28.5 3.0 17.9 44.1 8.2 6.5 9.1 2.9 1.9 5.7 18.7 1.3 13.3 17.1 16.6 6.0 3.6 13.8 9.4 9.9 26.4 1.3 5.6 24.8 5.3 21.2 15.0 21.3 4.9 4.1 23.4 2.4 7.3 6.6 7.0 9.2 5.7 10.0 1.9 31.4 8.7 0.8 2.8 18.6 0.7 1.9 4.3 3.4 23.0 30.1 10.2 10.0 4.6 2.0 3.8 3.7 21.0 4.6 2.6 21.4 8.7 2.4 7.4 8.8 6.4 4.7 5.2 5.7 7.1 4.2 6.8 7.0 1.0 4.7 7.2 3.4 2.8 6.2 9.6 9.4 8.9 8.1 6.5 7.6 6.1 6.2 7.7 5.9 ACO2 ACONM ENSG00000100412 "Aconitase 2" Q99798 22 41469125-41528989 "Citric acid cycle related proteins, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Tricarboxylic acid cycle" Lyase "Disease mutation, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "heart muscle: 121.0;skeletal muscle: 157.9" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA001097 Enhanced Approved Approved Mitochondria 4000000 Mitochondria "HPA001097: AB_1078092" "unprognostic (1.95e-1)" "unprognostic (2.50e-2)" "unprognostic (2.35e-2)" "unprognostic (3.06e-2)" "unprognostic (6.51e-2)" "unprognostic (1.26e-1)" "unprognostic (3.99e-2)" "unprognostic (6.54e-2)" "unprognostic (1.20e-2)" "unprognostic (7.32e-2)" "unprognostic (1.64e-2)" "unprognostic (6.07e-2)" "prognostic favourable (0.00e+0)" "unprognostic (1.46e-2)" "unprognostic (9.60e-2)" "unprognostic (6.45e-2)" "unprognostic (1.12e-2)" 22.8 18.5 41.4 11.1 38.2 9.8 12.2 21.0 43.5 12.2 25.4 27.7 12.3 45.1 9.5 9.9 17.5 15.7 11.1 121.0 33.8 24.2 37.9 22.2 10.0 11.1 27.6 32.7 8.6 17.2 48.5 7.6 9.1 24.9 12.5 20.0 14.7 20.1 15.2 157.9 9.8 46.6 12.5 28.6 10.0 21.0 9.6 23.1 9.5 16.0 42.7 12.0 12.3 8.8 22.9 28.1 7.3 36.6 15.8 16.4 19.4 16.1 18.8 18.9 39.0 32.6 21.3 26.5 14.9 18.8 25.1 23.5 27.7 21.1 37.1 24.4 22.1 37.1 35.1 27.2 13.2 24.5 25.0 18.0 26.3 29.4 28.5 47.9 27.6 37.8 21.9 26.0 27.7 24.8 23.2 40.5 19.7 30.3 24.4 16.2 12.9 37.7 33.2 13.0 51.4 32.3 32.1 13.6 11.6 36.6 43.3 27.6 25.1 25.6 17.6 21.4 24.0 19.5 16.3 24.1 29.9 25.9 34.6 20.9 23.1 4.5 21.1 7.3 14.7 31.3 14.0 22.9 12.5 15.8 28.1 20.2 14.2 14.6 5.3 15.8 36.6 11.2 16.4 19.4 41.4 38.2 21.0 43.5 33.8 24.2 27.6 32.7 24.9 23.1 CS ENSG00000062485 "Citrate synthase" O75390 12 56271699-56300392 "Citric acid cycle related proteins, Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Tricarboxylic acid cycle" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 125.9" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "HPA038460, HPA038461, CAB075750, CAB075751, CAB075752, CAB075753, CAB075754" Enhanced Enhanced Mitochondria 4400000 Mitochondria "CAB075750: , CAB075751: , CAB075752: , CAB075753: , CAB075754: , HPA038460: AB_2676023, HPA038461: AB_2676024" "unprognostic (7.67e-3)" "unprognostic (3.80e-1)" "unprognostic (2.59e-2)" "unprognostic (2.50e-2)" "unprognostic (2.70e-2)" "unprognostic (1.25e-1)" "unprognostic (6.09e-3)" "unprognostic (3.34e-2)" "unprognostic (2.43e-1)" "unprognostic (5.58e-2)" "unprognostic (2.56e-1)" "unprognostic (1.97e-2)" "prognostic favourable (1.17e-4)" "unprognostic (1.20e-1)" "unprognostic (2.09e-1)" "unprognostic (1.30e-2)" "unprognostic (2.02e-1)" 37.1 35.5 11.9 16.3 20.4 19.3 55.6 28.5 43.8 17.2 27.4 14.1 11.3 25.3 19.9 10.8 31.7 16.5 14.0 79.2 11.2 14.5 26.7 12.3 17.3 30.8 12.3 14.2 16.9 20.7 28.1 14.3 11.9 24.8 16.2 32.7 19.8 23.1 17.5 125.9 22.8 27.0 21.2 15.0 18.4 21.4 7.9 11.1 20.7 17.9 48.2 26.1 22.9 19.1 19.5 37.1 59.6 27.8 15.9 19.7 18.2 35.4 38.4 31.3 40.7 41.7 38.8 20.4 29.6 29.1 52.1 36.5 54.1 34.9 69.4 29.1 37.3 38.5 86.6 44.5 49.9 24.1 44.0 47.7 27.9 39.0 23.4 58.3 34.3 42.7 42.6 40.9 49.6 58.6 49.3 41.7 45.5 28.5 48.2 18.0 24.9 55.5 47.0 36.8 52.4 32.3 36.1 41.2 27.0 38.3 45.6 30.0 63.5 34.0 38.8 26.3 36.9 37.1 31.2 27.5 41.9 45.2 24.3 42.9 24.7 14.5 22.0 59.6 15.2 27.8 19.7 19.5 18.3 14.3 37.1 16.7 19.4 15.4 9.8 15.9 27.0 20.5 19.3 18.2 11.9 20.4 28.5 43.8 11.2 14.5 12.3 14.2 24.8 11.1 DLAT "DLTA, PDC-E2" ENSG00000150768 "Dihydrolipoamide S-acetyltransferase" P10515 11 112024814-112064390 "Citric acid cycle related proteins, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" "Carbohydrate metabolism, Glucose metabolism, Tricarboxylic acid cycle" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "heart muscle: 55.4" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB003782, HPA040786, HPA062766" Supported Enhanced Mitochondria Mitochondria "CAB003782: , HPA040786: AB_2677136, HPA062766: AB_2684864" "unprognostic (4.57e-3)" "unprognostic (1.75e-1)" "prognostic favourable (6.19e-6)" "unprognostic (7.68e-2)" "unprognostic (2.41e-1)" "unprognostic (1.70e-2)" "prognostic unfavourable (7.49e-5)" "unprognostic (8.68e-2)" "unprognostic (5.36e-2)" "unprognostic (2.93e-1)" "unprognostic (2.23e-3)" "unprognostic (6.25e-2)" "prognostic favourable (1.95e-14)" "unprognostic (5.82e-2)" "unprognostic (4.12e-2)" "unprognostic (2.17e-1)" "unprognostic (6.15e-2)" 14.1 10.7 10.6 8.8 11.9 4.8 10.9 10.5 14.2 6.7 13.3 6.3 7.8 12.4 6.3 8.1 12.2 7.2 6.4 55.4 10.4 13.5 19.1 12.0 6.6 8.7 11.2 9.7 7.9 6.0 15.8 7.8 8.3 13.0 8.3 13.5 7.6 10.4 9.9 41.0 7.2 13.0 6.6 7.3 6.9 8.1 7.3 4.2 12.7 10.7 22.1 8.8 7.5 6.7 9.2 9.1 7.9 8.9 7.2 10.3 8.0 6.0 6.1 8.1 10.8 11.4 8.5 9.7 8.3 4.8 9.2 10.4 19.3 17.8 24.8 16.3 7.6 13.0 16.9 8.9 10.5 8.9 10.5 15.7 6.5 11.9 8.2 19.9 9.0 10.3 9.8 9.2 9.3 8.4 25.7 11.9 10.8 4.7 9.0 23.9 9.5 11.8 14.0 11.0 27.9 16.9 6.4 15.6 9.5 10.0 28.3 6.3 21.0 12.4 5.6 9.2 10.0 9.2 10.6 3.9 6.2 37.6 2.6 21.8 7.2 7.9 6.6 4.7 8.3 8.9 9.5 9.2 8.2 8.9 9.1 7.5 10.3 8.3 0.5 7.2 8.9 7.4 8.8 8.0 10.6 11.9 10.5 14.2 10.4 13.5 11.2 9.7 13.0 4.2 DLD "DLDH, GCSL, LAD" ENSG00000091140 "Dihydrolipoamide dehydrogenase" P09622 7 107890970-107931730 "Citric acid cycle related proteins, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins" Oxidoreductase "Disease mutation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA044849 Supported Supported Mitochondria 16000000 Mitochondria "HPA044849: " "unprognostic (2.01e-3)" "unprognostic (2.26e-1)" "unprognostic (1.27e-2)" "unprognostic (9.27e-2)" "unprognostic (5.01e-3)" "unprognostic (9.27e-2)" "unprognostic (2.48e-1)" "unprognostic (2.83e-2)" "unprognostic (1.19e-1)" "unprognostic (3.95e-2)" "unprognostic (9.43e-2)" "unprognostic (7.35e-2)" "prognostic favourable (7.58e-9)" "unprognostic (4.08e-2)" "unprognostic (1.88e-1)" "unprognostic (4.45e-3)" "unprognostic (1.18e-1)" 25.7 37.9 14.5 12.7 25.4 12.0 15.2 16.6 27.2 13.2 28.0 10.6 12.2 20.9 13.6 9.6 25.6 11.6 12.7 69.1 16.4 14.4 40.7 37.9 11.0 13.0 16.7 20.1 15.1 14.8 24.6 22.4 15.4 29.3 14.7 26.8 12.8 19.4 14.4 71.5 13.8 29.5 23.7 10.6 17.4 23.0 10.6 10.7 18.7 17.0 31.8 16.9 20.1 11.7 13.5 30.4 45.8 37.8 22.9 19.4 20.2 39.9 32.4 18.0 31.0 25.9 22.9 20.4 23.0 19.4 26.8 20.8 37.9 22.4 39.1 39.7 24.4 26.6 36.2 32.4 40.5 26.1 21.5 27.5 43.0 27.0 19.9 45.2 28.4 26.1 23.6 28.4 15.5 32.1 68.6 29.2 29.0 44.9 36.9 32.8 21.4 23.5 26.6 28.8 53.0 36.6 59.8 22.4 23.7 37.7 63.7 33.8 24.2 38.7 20.3 29.6 24.3 57.6 34.9 22.1 42.1 26.3 27.9 48.3 30.6 36.5 22.3 45.8 17.5 28.2 18.5 13.5 17.7 17.3 30.4 12.3 18.7 19.4 14.0 22.9 37.8 10.5 16.8 20.2 14.5 25.4 16.6 27.2 16.4 14.4 16.7 20.1 29.3 10.7 DLST DLTS ENSG00000119689 "Dihydrolipoamide S-succinyltransferase" P36957 14 74881891-74903745 "Citric acid cycle related proteins, Enzymes, Predicted intracellular proteins" "Tricarboxylic acid cycle" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA003010 Supported 800000 "HPA003010: AB_1078679" "unprognostic (1.62e-1)" "unprognostic (3.01e-1)" "unprognostic (2.45e-3)" "unprognostic (6.36e-2)" "unprognostic (1.29e-1)" "unprognostic (1.21e-2)" "unprognostic (1.16e-1)" "unprognostic (5.83e-2)" "unprognostic (3.03e-1)" "unprognostic (1.37e-1)" "unprognostic (2.12e-2)" "unprognostic (1.18e-1)" "prognostic favourable (1.13e-12)" "unprognostic (3.29e-2)" "unprognostic (1.08e-1)" "unprognostic (1.66e-1)" "unprognostic (4.55e-3)" 32.2 38.6 12.0 22.7 19.9 28.5 31.3 19.1 25.6 31.2 36.0 18.5 15.9 24.7 26.3 28.3 31.4 19.2 29.7 47.6 10.8 11.8 43.7 45.1 20.8 26.7 13.5 13.7 21.5 27.1 25.8 16.2 25.2 19.7 20.9 26.8 19.2 22.3 20.1 59.2 26.9 43.2 32.9 11.4 20.8 24.3 21.0 10.4 23.5 27.2 49.8 28.4 26.9 21.1 3.8 6.3 8.4 4.3 7.7 5.3 3.2 26.3 27.5 21.0 14.9 33.0 37.5 32.3 34.4 35.0 35.2 33.0 27.0 28.6 26.8 14.7 39.5 29.7 35.4 34.0 37.3 19.4 14.8 21.8 23.0 23.6 34.2 15.5 15.1 38.4 29.8 34.1 42.1 36.3 16.7 18.2 38.2 35.3 18.4 22.0 18.0 25.9 23.5 30.9 14.7 43.7 32.4 25.1 21.2 32.5 43.4 22.4 39.7 22.4 32.1 21.4 28.1 26.2 23.5 12.9 13.4 23.5 31.4 16.1 22.4 8.4 3.0 5.0 5.0 4.3 4.5 3.8 4.5 3.9 4.7 2.7 4.0 5.3 3.0 7.7 3.9 6.3 4.4 3.2 12.0 19.9 19.1 25.6 10.8 11.8 13.5 13.7 19.7 10.4 FH fumarase ENSG00000091483 "Fumarate hydratase" P07954 1 241497603-241519761 "Cancer-related genes, Citric acid cycle related proteins, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "DNA damage, DNA repair, Tricarboxylic acid cycle" Lyase "Cancer-related genes, Disease mutation, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 93.4" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB017785, HPA025770, HPA025948, HPA027341" Enhanced Supported Enhanced Mitochondria 2800000 Mitochondria "CAB017785: , HPA025770: AB_10599603, HPA025948: AB_10602177, HPA027341: AB_10601222" "unprognostic (1.03e-2)" "unprognostic (3.82e-2)" "unprognostic (9.46e-3)" "unprognostic (2.18e-1)" "unprognostic (2.10e-1)" "unprognostic (2.07e-1)" "unprognostic (2.28e-2)" "unprognostic (1.55e-1)" "unprognostic (5.14e-2)" "unprognostic (1.85e-2)" "unprognostic (1.27e-2)" "unprognostic (1.09e-1)" "prognostic favourable (2.76e-7)" "unprognostic (1.05e-1)" "unprognostic (1.05e-1)" "unprognostic (4.41e-2)" "unprognostic (1.24e-2)" 14.3 28.1 15.7 10.4 20.2 9.3 13.3 15.7 24.4 10.5 22.7 9.9 16.7 23.2 13.7 10.7 17.7 10.3 9.5 59.0 22.9 13.9 35.0 93.4 9.9 13.3 15.2 19.4 9.4 13.9 25.2 11.4 14.3 18.4 12.3 24.4 10.2 18.4 20.6 65.1 13.4 21.4 14.7 14.4 11.1 17.5 14.0 11.7 13.8 12.3 45.2 13.4 13.4 11.2 16.0 26.4 4.5 18.8 10.4 13.9 8.9 29.2 24.5 23.3 21.0 22.9 27.0 36.9 36.3 28.5 41.0 25.8 35.1 18.3 18.6 24.1 27.8 41.7 35.6 27.0 35.8 21.2 11.5 17.4 26.0 29.9 20.5 40.7 15.9 19.5 16.8 23.0 26.0 25.2 53.0 24.1 29.8 14.6 35.1 27.2 24.7 52.7 29.0 25.5 83.5 39.5 24.9 30.0 25.9 30.6 36.3 23.2 27.6 27.7 24.7 18.4 23.8 32.5 60.5 21.6 23.1 22.6 20.6 46.8 26.4 4.5 12.8 2.7 9.7 18.8 12.6 16.0 11.4 9.0 26.4 14.1 13.9 12.7 0.7 10.4 15.7 13.2 13.2 8.9 15.7 20.2 15.7 24.4 22.9 13.9 15.2 19.4 18.4 11.7 IDH1 ENSG00000138413 "Isocitrate dehydrogenase (NADP(+)) 1, cytosolic" O75874 2 208236227-208266074 "Cancer-related genes, Citric acid cycle related proteins, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Glyoxylate bypass, Tricarboxylic acid cycle" Oxidoreductase "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell line enhanced" "Detected in all" "Hep G2: 108.5;RT4: 75.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB033218, HPA035248, HPA057936, CAB062556" Enhanced Approved "Nuclear bodies,Cytosol" 16000000 "Nuclear bodies, Cytosol" "CAB033218: AB_2123166, CAB062556: , HPA035248: AB_10600714, HPA057936: " "unprognostic (2.79e-1)" "unprognostic (1.00e-1)" "unprognostic (1.02e-1)" "unprognostic (2.47e-3)" "unprognostic (1.93e-1)" "unprognostic (2.39e-2)" "prognostic unfavourable (6.93e-5)" "unprognostic (3.32e-1)" "unprognostic (2.20e-3)" "unprognostic (8.03e-2)" "unprognostic (5.54e-2)" "unprognostic (4.18e-3)" "prognostic unfavourable (2.45e-5)" "unprognostic (2.09e-1)" "unprognostic (1.77e-1)" "unprognostic (1.13e-1)" "unprognostic (2.69e-2)" 41.3 82.3 6.2 8.8 7.0 1.3 20.9 6.5 8.3 12.6 35.2 8.7 38.0 30.6 8.0 29.9 30.3 8.8 18.7 10.8 6.3 6.2 20.5 91.0 19.8 14.3 8.1 4.7 19.4 21.5 4.8 6.2 24.1 8.7 38.5 23.1 15.4 18.7 39.0 4.7 7.4 54.1 10.1 9.3 21.3 20.4 15.6 8.4 3.5 7.9 11.0 11.9 43.4 12.1 4.9 22.8 6.4 31.6 7.4 6.6 12.0 9.6 16.2 23.2 9.4 42.2 30.1 13.2 4.0 18.4 6.8 16.6 25.6 23.6 1.9 25.6 12.5 14.9 16.7 19.4 6.6 1.3 6.3 8.3 13.4 108.5 56.2 5.4 8.3 25.9 41.3 15.5 11.3 18.7 8.3 6.7 10.4 6.1 3.8 9.3 42.4 6.7 3.7 8.4 5.4 30.6 75.8 4.0 6.9 15.3 14.8 50.1 5.7 15.8 12.3 6.9 7.0 9.8 4.3 3.2 5.0 2.5 22.4 32.8 5.5 5.7 31.6 4.8 4.5 14.5 5.1 4.9 4.0 5.3 22.8 4.9 3.3 3.9 6.4 7.4 6.5 8.4 6.6 12.0 6.2 7.0 6.5 8.3 6.3 6.2 8.1 4.7 8.7 8.4 IDH2 ENSG00000182054 "Isocitrate dehydrogenase (NADP(+)) 2, mitochondrial" P48735 15 90083045-90102504 "Cancer-related genes, Citric acid cycle related proteins, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins" "Glyoxylate bypass, Tricarboxylic acid cycle" Oxidoreductase "Cancer-related genes, Disease mutation, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "heart muscle: 126.2;skeletal muscle: 190.7" "Cell line enhanced" "Detected in all" "MOLT-4: 68.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA007831 Enhanced Supported Mitochondria 53000000 Mitochondria "HPA007831: AB_1851397" "unprognostic (2.45e-2)" "prognostic favourable (5.15e-5)" "unprognostic (2.92e-1)" "unprognostic (1.53e-1)" "unprognostic (3.53e-1)" "unprognostic (8.46e-2)" "unprognostic (3.83e-2)" "unprognostic (2.55e-3)" "unprognostic (1.86e-2)" "unprognostic (1.89e-2)" "unprognostic (2.76e-1)" "unprognostic (4.90e-2)" "unprognostic (2.19e-3)" "unprognostic (3.92e-3)" "unprognostic (4.46e-1)" "unprognostic (1.30e-2)" "unprognostic (2.58e-2)" 5.4 2.0 14.9 10.1 16.6 22.6 8.8 4.9 19.1 6.4 16.2 13.8 12.4 16.1 5.9 15.3 23.7 6.0 9.4 126.2 10.2 9.3 25.0 93.2 6.9 15.8 14.4 12.0 3.0 25.1 8.4 3.3 15.1 11.9 13.3 14.5 6.0 28.0 21.9 190.7 11.0 13.9 15.8 11.0 7.5 27.9 1.2 7.6 28.2 3.4 69.0 13.6 11.0 8.6 16.8 32.8 17.2 56.3 22.2 29.5 31.2 10.2 5.8 30.2 30.0 4.2 5.2 25.7 12.8 19.5 12.1 13.0 2.7 8.9 12.2 3.6 10.6 3.5 4.4 3.9 5.8 23.9 2.9 20.8 2.2 20.3 5.1 14.2 21.1 10.8 2.2 2.9 2.3 24.8 3.1 10.5 9.3 29.8 68.3 22.1 9.0 2.4 57.9 21.7 36.3 18.7 12.3 43.6 22.1 15.9 63.6 5.1 51.3 43.9 5.9 21.7 3.1 2.8 5.9 17.3 3.2 1.4 6.9 30.0 12.5 9.0 26.4 17.2 26.1 48.0 12.4 16.8 18.7 29.5 32.8 9.8 10.2 18.2 5.1 22.2 56.3 17.8 15.9 31.2 14.9 16.6 4.9 19.1 10.2 9.3 14.4 12.0 11.9 7.6 IDH3A ENSG00000166411 "Isocitrate dehydrogenase 3 (NAD(+)) alpha" P50213 15 78131498-78171949 "Citric acid cycle related proteins, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins" "Tricarboxylic acid cycle" Oxidoreductase "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Cell type enhanced" "Detected in all" "plasmacytoid DC: 47.2" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA041465, HPA062971" Supported Enhanced Mitochondria 2000000 Mitochondria "HPA041465: AB_10794377, HPA062971: AB_2684913" "unprognostic (2.33e-1)" "unprognostic (1.21e-1)" "unprognostic (5.76e-3)" "unprognostic (2.26e-1)" "unprognostic (1.02e-1)" "unprognostic (4.01e-1)" "unprognostic (2.29e-1)" "unprognostic (6.47e-2)" "unprognostic (1.69e-2)" "unprognostic (2.30e-1)" "unprognostic (3.05e-1)" "unprognostic (1.42e-1)" "prognostic favourable (6.49e-8)" "unprognostic (1.40e-1)" "unprognostic (3.08e-2)" "unprognostic (4.49e-2)" "unprognostic (3.39e-2)" 14.6 18.1 18.0 13.0 25.3 6.5 7.7 16.1 29.5 9.9 17.6 11.9 6.1 24.5 11.2 5.9 12.0 8.4 6.5 41.5 16.6 16.8 15.2 10.4 8.8 11.0 20.6 18.1 8.0 9.2 18.5 12.4 8.4 29.0 10.1 18.8 10.4 11.2 11.9 47.7 11.1 23.8 11.9 18.1 10.1 8.9 11.5 13.8 16.2 8.1 26.5 16.4 11.1 10.3 10.1 47.2 6.1 17.0 5.5 6.0 7.4 15.9 21.9 4.0 13.9 10.0 10.2 8.7 19.0 9.3 15.5 11.8 15.5 9.7 34.0 14.1 11.1 24.1 36.9 14.7 14.4 14.9 12.2 13.1 23.7 7.0 8.5 25.4 18.8 7.7 9.1 15.1 15.9 9.7 16.8 14.0 9.8 15.2 18.6 6.8 4.9 8.2 10.8 17.0 10.6 12.9 21.7 15.9 6.1 21.8 31.2 17.6 12.4 13.8 10.0 18.3 17.0 24.1 30.6 16.0 35.6 18.1 12.9 24.3 14.3 4.2 9.4 2.7 5.3 17.0 5.7 9.2 5.2 4.8 14.2 10.1 5.6 6.0 6.1 5.5 16.6 47.2 5.6 7.4 18.0 25.3 16.1 29.5 16.6 16.8 20.6 18.1 29.0 13.8 IDH3B RP46 ENSG00000101365 "Isocitrate dehydrogenase 3 (NAD(+)) beta" O43837 20 2658395-2664219 "Citric acid cycle related proteins, Disease related genes, Plasma proteins, Predicted intracellular proteins" "Tricarboxylic acid cycle" "Disease mutation, Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA049387, HPA054180" Supported Enhanced Mitochondria Mitochondria "HPA049387: AB_2680740, HPA054180: AB_2682407" "unprognostic (1.19e-1)" "unprognostic (1.47e-1)" "unprognostic (2.12e-1)" "unprognostic (2.43e-2)" "unprognostic (3.24e-2)" "unprognostic (6.83e-2)" "prognostic unfavourable (1.59e-4)" "unprognostic (2.76e-2)" "unprognostic (2.99e-1)" "unprognostic (5.69e-2)" "unprognostic (4.75e-3)" "unprognostic (1.39e-2)" "prognostic favourable (6.78e-8)" "unprognostic (8.89e-2)" "unprognostic (4.02e-2)" "unprognostic (2.79e-1)" "unprognostic (1.16e-1)" 19.5 20.0 19.4 15.5 31.7 20.6 18.5 32.1 30.5 16.4 23.9 16.9 14.5 30.5 19.2 16.7 20.7 17.9 19.2 57.3 19.8 20.0 29.7 25.2 15.1 17.6 24.0 29.4 20.2 15.2 27.6 12.2 17.0 31.2 15.4 25.6 16.2 19.3 19.5 75.5 20.9 24.9 21.5 17.1 19.2 19.9 19.6 16.0 19.7 19.1 37.7 22.5 16.7 17.4 34.7 49.4 25.8 44.7 29.5 38.6 33.9 26.1 35.5 16.2 14.1 18.0 14.2 18.8 14.1 18.0 33.3 26.6 45.7 27.6 29.6 12.9 19.3 37.0 29.9 45.7 30.6 8.1 23.5 35.9 13.8 47.3 17.6 39.0 7.8 18.8 17.6 31.1 16.4 19.6 45.3 16.6 20.2 14.4 33.9 44.8 31.5 33.7 27.8 29.6 33.2 19.1 24.6 29.3 21.2 17.3 57.7 29.7 28.9 17.4 17.4 26.0 16.4 8.8 32.3 22.6 51.6 31.2 12.2 40.4 24.6 22.2 41.7 25.8 33.9 44.7 25.6 34.7 29.4 30.7 49.4 30.6 34.4 29.8 11.9 29.5 38.3 22.9 38.6 33.9 19.4 31.7 32.1 30.5 19.8 20.0 24.0 29.4 31.2 16.0 IDH3G ENSG00000067829 "Isocitrate dehydrogenase 3 (NAD(+)) gamma" P51553 X 153785766-153794523 "Citric acid cycle related proteins, Plasma proteins, Predicted intracellular proteins" "Tricarboxylic acid cycle" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA000425, HPA002017" Supported Approved Nucleoli,Mitochondria "Nucleoli, Mitochondria" "HPA000425: AB_1079097, HPA002017: AB_1079096" "unprognostic (4.24e-2)" "unprognostic (1.43e-3)" "unprognostic (5.75e-2)" "unprognostic (1.05e-1)" "unprognostic (6.57e-2)" "unprognostic (2.25e-1)" "unprognostic (4.35e-2)" "unprognostic (1.58e-1)" "unprognostic (2.24e-2)" "unprognostic (1.59e-2)" "unprognostic (2.81e-2)" "unprognostic (1.96e-1)" "prognostic favourable (5.73e-6)" "unprognostic (1.50e-1)" "unprognostic (3.35e-1)" "unprognostic (2.91e-2)" "unprognostic (2.46e-1)" 24.5 34.0 27.7 26.8 47.2 37.1 24.1 37.2 61.5 25.0 28.8 25.7 24.6 34.7 26.6 21.3 31.8 29.4 25.6 50.8 35.0 25.2 40.6 29.5 20.9 25.6 27.3 35.6 31.8 40.5 29.1 24.9 22.5 40.5 21.4 25.2 26.0 34.5 29.8 54.9 36.3 34.9 24.8 20.1 26.9 24.8 16.0 23.3 31.2 24.3 37.1 28.2 24.4 21.1 20.6 45.5 43.7 44.4 23.7 28.8 33.6 28.9 26.7 15.8 22.2 24.8 20.5 19.4 15.1 21.3 26.8 28.5 22.1 22.1 36.9 26.2 24.2 21.7 23.9 20.6 9.9 12.1 30.5 13.8 36.3 17.7 28.1 19.2 29.2 23.1 14.9 20.7 22.6 20.5 7.6 20.3 21.6 40.5 21.8 22.6 7.1 35.4 19.3 13.5 32.2 29.9 18.0 20.2 13.8 9.4 32.0 15.0 13.3 16.6 18.1 17.0 10.7 25.0 35.7 27.9 6.9 47.0 27.8 23.9 18.8 42.5 43.9 43.7 21.5 44.4 19.9 19.1 22.0 20.9 45.5 20.6 17.6 19.2 16.3 23.7 43.1 27.9 28.8 33.6 27.7 47.2 37.2 61.5 35.0 25.2 27.3 35.6 40.5 23.3 MDH1 ENSG00000014641 "Malate dehydrogenase 1" P40925 2 63588609-63607197 "Cancer-related genes, Citric acid cycle related proteins, Enzymes, Plasma proteins, Predicted intracellular proteins" "Tricarboxylic acid cycle" Oxidoreductase "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "heart muscle: 155.8" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA027296, CAB047333, HPA054276" Uncertain Supported Centrosome,Cytosol 63000000 "Centrosome, Cytosol" "CAB047333: , HPA027296: AB_10611118, HPA054276: " "unprognostic (1.01e-1)" "unprognostic (6.52e-3)" "unprognostic (1.61e-2)" "prognostic unfavourable (7.13e-4)" "unprognostic (1.83e-1)" "unprognostic (8.84e-3)" "unprognostic (5.81e-2)" "unprognostic (2.79e-2)" "unprognostic (9.52e-2)" "unprognostic (2.05e-1)" "unprognostic (3.26e-1)" "unprognostic (8.80e-2)" "prognostic favourable (9.95e-4)" "unprognostic (6.37e-2)" "unprognostic (1.75e-1)" "unprognostic (5.97e-2)" "unprognostic (3.05e-1)" 32.0 28.6 28.0 10.5 58.1 9.2 18.4 38.0 69.5 12.4 21.4 12.5 9.0 19.3 13.4 22.6 16.7 14.7 11.5 155.8 33.6 37.5 47.6 33.2 11.2 14.7 33.4 40.1 10.9 8.9 26.0 18.3 11.4 65.9 16.1 24.9 13.8 15.4 19.9 91.1 11.1 17.1 21.5 18.6 9.4 22.4 8.6 12.2 14.1 15.6 47.1 20.2 15.6 10.2 61.7 57.1 50.7 61.5 46.7 74.5 67.8 44.0 36.1 48.8 31.9 69.4 51.4 50.6 34.7 51.3 52.9 53.7 42.7 39.1 55.5 20.6 45.4 38.8 54.9 64.3 75.9 33.6 42.4 52.1 33.8 67.8 38.1 59.9 41.3 50.9 43.9 49.5 29.3 40.3 28.8 40.4 69.5 26.5 52.4 60.5 28.6 45.0 41.9 57.5 54.4 87.5 41.8 45.3 27.0 29.1 46.9 66.5 34.2 62.5 23.4 40.6 39.8 33.7 43.6 50.4 44.2 67.9 50.1 54.2 33.5 50.7 45.8 45.8 52.7 61.5 55.0 61.7 61.3 57.6 57.1 56.4 60.5 57.5 7.0 46.7 55.7 43.3 74.5 67.8 28.0 58.1 38.0 69.5 33.6 37.5 33.4 40.1 65.9 12.2 MDH2 ENSG00000146701 "Malate dehydrogenase 2" P40926 7 76048051-76067508 "Citric acid cycle related proteins, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins" "Tricarboxylic acid cycle" Oxidoreductase "Disease mutation, Epilepsy, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 175.8" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA019714, HPA019716, HPA019848, HPA026720" Enhanced Enhanced Mitochondria 47000000 Mitochondria "HPA019714: AB_1853678, HPA019716: AB_1853680, HPA019848: AB_1853683, HPA026720: AB_1853685" "unprognostic (3.20e-2)" "unprognostic (2.85e-1)" "unprognostic (1.11e-1)" "unprognostic (1.43e-2)" "unprognostic (5.55e-3)" "unprognostic (8.94e-2)" "unprognostic (6.45e-2)" "unprognostic (3.77e-2)" "unprognostic (3.60e-1)" "unprognostic (2.02e-2)" "unprognostic (1.40e-1)" "unprognostic (9.70e-2)" "prognostic favourable (1.49e-5)" "unprognostic (8.57e-2)" "unprognostic (9.64e-2)" "unprognostic (5.68e-2)" "unprognostic (2.66e-1)" 18.1 39.1 17.4 15.4 20.6 18.3 22.2 15.3 34.4 14.9 27.0 13.5 16.9 32.5 16.6 13.5 31.8 19.4 17.6 103.1 17.1 18.8 29.1 101.9 13.8 26.6 17.4 21.9 17.3 35.5 16.8 16.9 17.5 20.5 17.9 24.3 15.0 26.8 21.5 175.8 24.6 26.7 21.9 12.8 21.1 22.3 17.6 9.5 22.4 20.1 76.2 23.8 19.9 17.8 37.1 52.8 22.1 45.3 30.1 45.6 44.7 28.6 47.0 17.0 42.6 19.5 21.4 29.3 19.3 24.9 27.6 25.0 41.3 34.5 43.4 8.7 25.4 29.3 43.7 28.8 19.8 30.9 63.2 24.1 25.3 38.1 24.0 37.4 24.9 27.0 25.7 26.8 40.1 25.7 75.8 25.4 25.5 64.9 32.4 66.1 37.9 59.3 26.5 21.0 62.4 25.8 37.9 42.7 38.9 19.3 96.8 39.7 55.0 42.3 19.8 27.8 26.3 30.0 38.3 28.5 23.5 48.0 24.1 48.0 42.1 22.1 38.9 18.2 32.7 43.5 34.2 37.1 36.9 35.3 52.8 32.1 36.0 33.1 10.2 30.1 45.3 47.1 45.6 44.7 17.4 20.6 15.3 34.4 17.1 18.8 17.4 21.9 20.5 9.5 OGDH E1k ENSG00000105953 "Oxoglutarate dehydrogenase" Q02218 7 44606572-44709066 "Citric acid cycle related proteins, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins" Glycolysis Oxidoreductase "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 99.3" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA019514, HPA020347" Supported Enhanced Mitochondria 53000 Mitochondria "HPA019514: AB_1854772, HPA020347: AB_1854773" "unprognostic (1.96e-2)" "unprognostic (1.40e-1)" "unprognostic (4.39e-1)" "unprognostic (5.64e-3)" "unprognostic (3.02e-3)" "unprognostic (1.20e-1)" "unprognostic (3.45e-1)" "unprognostic (7.58e-2)" "unprognostic (1.74e-1)" "unprognostic (1.52e-2)" "unprognostic (3.38e-1)" "unprognostic (3.30e-2)" "prognostic favourable (2.22e-14)" "unprognostic (1.53e-1)" "unprognostic (1.62e-1)" "unprognostic (2.23e-2)" "unprognostic (5.88e-3)" 18.9 20.8 12.3 14.5 18.5 8.7 11.0 14.3 23.7 10.1 19.4 15.9 13.5 29.0 16.2 11.1 19.5 11.1 11.8 73.9 11.3 12.8 28.8 14.8 13.0 11.1 14.2 11.7 9.8 13.0 25.5 11.0 14.5 22.2 12.3 13.3 22.3 23.7 15.9 99.3 15.6 35.5 16.4 10.1 12.1 14.9 11.3 11.0 11.3 17.8 39.8 15.8 13.0 10.8 7.2 13.4 7.5 20.4 11.2 25.7 11.6 10.8 22.8 13.7 20.8 21.2 23.3 13.4 17.0 16.6 19.4 16.9 20.8 22.5 47.8 20.2 24.7 33.8 27.0 25.4 18.9 27.9 7.1 14.5 46.2 10.2 10.8 17.9 16.3 21.6 19.3 27.4 19.7 26.2 16.7 14.3 20.4 15.3 17.7 10.3 12.6 25.8 17.0 9.6 53.7 22.2 32.4 23.4 11.2 24.6 34.1 10.6 20.2 18.0 20.6 14.0 12.6 24.2 19.6 13.0 24.9 26.4 25.3 20.3 25.3 4.8 12.1 7.3 11.7 17.7 12.8 7.2 13.5 11.7 13.4 5.9 5.8 7.0 7.5 11.2 20.4 6.6 25.7 11.6 12.3 18.5 14.3 23.7 11.3 12.8 14.2 11.7 22.2 11.0 OGDHL FLJ10851 ENSG00000197444 "Oxoglutarate dehydrogenase like" Q9ULD0 10 49734643-49762379 "Citric acid cycle related proteins, Predicted intracellular proteins" Glycolysis Oxidoreductase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "kidney: 74.9;liver: 48.8" "Cell line enhanced" "Detected in some" "AN3-CA: 13.4;RPTEC TERT1: 27.6;SH-SY5Y: 10.4;SK-BR-3: 10.2" "Cancer enhanced" "Detected in many" "renal cancer: 44.9" "Low region specificity" "Detected in all" "Cell type enriched" "Detected in single" 11 "memory CD8 T-cell: 1.1" "Lineage enriched" "Detected in single" 11 "T-cells: 1.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA043716, HPA052497" Enhanced Approved "Nucleoli fibrillar center" "Nucleoli fibrillar center" "HPA043716: , HPA052497: " "unprognostic (9.05e-2)" "unprognostic (3.93e-3)" "unprognostic (5.30e-2)" "unprognostic (2.50e-1)" "unprognostic (3.70e-3)" "unprognostic (2.03e-1)" "unprognostic (1.46e-3)" "unprognostic (4.19e-1)" "unprognostic (2.07e-1)" "unprognostic (1.46e-2)" "unprognostic (1.52e-3)" "unprognostic (4.60e-1)" "prognostic favourable (1.21e-14)" "unprognostic (3.25e-2)" "unprognostic (1.85e-1)" "unprognostic (1.59e-3)" "unprognostic (8.38e-2)" 0.9 8.1 8.3 1.0 15.3 0.8 0.8 16.2 23.6 1.3 1.3 4.9 2.7 1.4 2.2 1.7 0.9 1.5 1.1 4.1 8.7 13.7 74.9 48.8 0.8 0.9 12.1 11.0 1.9 3.4 23.1 11.7 0.9 23.6 1.8 1.0 8.2 10.3 5.0 0.9 0.8 1.4 1.2 2.9 1.0 1.4 1.9 3.2 0.0 13.0 0.0 1.1 1.4 0.2 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.0 0.0 2.9 13.4 0.0 0.0 1.7 0.0 0.0 0.7 0.1 6.4 1.4 0.0 7.2 0.0 0.2 4.6 0.1 0.2 0.0 0.3 0.0 0.1 3.2 0.1 0.0 1.0 0.2 0.0 0.0 0.0 0.0 0.3 0.0 0.0 1.9 4.9 4.4 1.2 0.6 0.0 0.0 0.0 27.6 0.4 7.6 10.4 0.1 10.2 0.7 2.8 1.8 0.0 0.0 7.0 0.0 0.4 0.1 0.1 0.0 0.0 1.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 8.3 15.3 16.2 23.6 8.7 13.7 12.1 11.0 23.6 3.2 PC PCB ENSG00000173599 "Pyruvate carboxylase" P11498 11 66848233-66958376 "Citric acid cycle related proteins, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Gluconeogenesis, Lipid biosynthesis, Lipid metabolism" "Ligase, Multifunctional enzyme" "Disease mutation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "adipose tissue: 41.1;liver: 76.0" "Cell line enhanced" "Detected in many" "HeLa: 27.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Group enriched" "Detected in many" 5 "dendritic cells: 2.6;monocytes: 3.8;T-cells: 2.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB033742, HPA043922, HPA058765" Enhanced Enhanced Mitochondria 96000 Mitochondria "CAB033742: AB_2283532, HPA043922: AB_2678732, HPA058765: AB_2683812" "unprognostic (2.10e-1)" "unprognostic (1.51e-1)" "unprognostic (1.36e-2)" "unprognostic (8.24e-3)" "unprognostic (3.67e-1)" "unprognostic (3.18e-2)" "unprognostic (2.97e-1)" "unprognostic (3.00e-1)" "unprognostic (3.63e-1)" "prognostic unfavourable (7.86e-5)" "unprognostic (1.54e-1)" "unprognostic (1.17e-1)" "prognostic favourable (8.22e-5)" "unprognostic (8.58e-3)" "unprognostic (5.67e-2)" "unprognostic (9.15e-3)" "unprognostic (1.05e-1)" 41.1 10.7 11.1 2.8 14.6 3.1 12.9 13.1 14.9 2.4 3.8 10.7 21.4 5.6 2.1 2.4 5.0 2.7 2.9 4.0 11.3 8.9 18.7 76.0 2.1 1.6 15.5 11.5 4.4 4.3 19.4 4.0 4.1 10.9 5.4 3.1 3.4 24.2 24.4 5.7 2.8 6.7 1.8 9.4 1.5 3.3 6.1 13.1 0.6 4.2 2.5 2.5 2.2 2.1 0.6 2.6 0.0 3.8 0.3 2.9 2.0 2.9 8.9 3.3 8.1 13.7 5.4 3.5 1.8 7.8 3.5 3.4 4.4 3.2 0.0 3.7 2.9 3.8 3.7 20.6 1.0 1.7 5.2 4.4 27.7 17.0 10.7 0.0 5.7 20.6 5.3 2.8 6.4 2.9 8.4 0.0 1.2 19.0 5.0 2.4 6.3 7.4 3.7 6.9 1.8 3.2 0.9 7.2 10.2 17.3 9.2 7.0 7.5 1.2 3.2 3.9 3.6 4.6 2.0 1.9 2.2 0.0 4.0 2.8 3.3 0.0 3.8 0.0 1.2 0.9 1.4 0.2 0.5 1.9 2.6 0.6 2.9 1.6 0.0 0.3 0.5 1.0 1.5 2.0 11.1 14.6 13.1 13.6 11.3 8.9 15.5 11.5 10.9 13.1 PCK1 PEPCK-C ENSG00000124253 "Phosphoenolpyruvate carboxykinase 1" P35558 20 57561080-57568112 "Citric acid cycle related proteins, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" Gluconeogenesis "Decarboxylase, Lyase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 6 "liver: 419.5" "Cell line enriched" "Detected in some" 10 "ASC diff: 21.5" "Cancer enriched" "Detected in many" 5 "liver cancer: 99.3" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in all" "HPA006277, HPA006507, CAB017027" Approved 380000 "CAB017027: , HPA006277: AB_1079579, HPA006507: AB_1079578" "unprognostic (3.50e-2)" "unprognostic (5.60e-2)" "unprognostic (4.60e-2)" "unprognostic (8.62e-3)" "unprognostic (1.99e-1)" "unprognostic (1.28e-1)" "unprognostic (1.21e-2)" "unprognostic (4.43e-2)" "unprognostic (1.84e-1)" "unprognostic (2.37e-1)" "unprognostic (1.64e-1)" "prognostic favourable (1.47e-5)" "unprognostic (1.03e-1)" "unprognostic (6.40e-2)" "unprognostic (1.05e-3)" "unprognostic (2.21e-1)" 10.0 0.1 0.4 2.2 0.4 0.0 11.1 0.2 0.6 0.1 52.0 0.2 0.1 19.2 0.1 0.7 0.2 0.1 5.6 0.4 0.3 0.2 72.0 419.5 0.2 0.3 0.2 0.2 0.4 0.2 0.0 5.0 0.1 0.5 0.2 14.0 0.2 0.2 0.1 0.3 0.1 58.5 0.4 0.1 0.1 0.1 0.2 0.2 0.1 0.4 0.4 0.3 0.4 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 21.5 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.1 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.4 0.3 0.0 0.0 0.1 0.3 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.2 0.0 0.0 0.0 2.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.4 0.2 0.6 0.3 0.2 0.2 0.2 0.5 0.2 PCK2 "PEPCK, PEPCK2" ENSG00000100889 "Phosphoenolpyruvate carboxykinase 2, mitochondrial" Q16822 14 24094053-24110598 "Citric acid cycle related proteins, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins" Gluconeogenesis "Decarboxylase, Lyase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in all" 5 "intestine: 156.3;liver: 115.1" "Cell line enhanced" "Detected in many" "HHSteC: 34.9;hTCEpi: 33.9;SK-MEL-30: 32.1" "Cancer enhanced" "Detected in all" "liver cancer: 91.3" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB018734, HPA051162, HPA053502" Enhanced Enhanced Mitochondria 3300000 Mitochondria "CAB018734: AB_2160168, HPA051162: AB_2681368, HPA053502: AB_2682171" "unprognostic (3.38e-2)" "unprognostic (1.13e-1)" "unprognostic (1.50e-2)" "unprognostic (4.07e-1)" "unprognostic (3.11e-1)" "unprognostic (2.10e-1)" "prognostic favourable (2.81e-4)" "unprognostic (3.91e-2)" "unprognostic (1.04e-1)" "unprognostic (2.18e-2)" "unprognostic (1.26e-1)" "unprognostic (3.67e-2)" "unprognostic (1.33e-2)" "unprognostic (2.81e-1)" "unprognostic (3.71e-1)" "unprognostic (2.82e-2)" "unprognostic (1.17e-1)" 8.2 2.5 1.0 4.9 1.9 1.0 4.3 1.3 1.3 1.3 69.7 1.4 6.9 51.8 1.3 8.5 4.5 1.2 4.2 2.6 1.5 1.0 26.4 115.1 6.0 4.4 1.7 1.2 1.8 8.5 3.4 1.7 1.2 1.8 2.0 5.4 1.9 11.5 4.9 1.0 2.7 156.3 1.1 1.7 6.7 3.3 3.9 1.3 1.3 5.8 1.9 4.6 2.8 1.9 8.8 10.8 2.4 15.1 1.5 6.5 3.9 5.4 3.1 0.9 5.8 3.6 3.7 14.8 6.8 8.2 5.7 9.3 5.1 6.3 13.9 0.8 10.5 8.0 6.0 8.8 4.7 7.1 0.2 2.5 1.7 27.2 34.9 4.8 11.0 4.3 33.9 3.6 8.8 4.6 7.1 25.8 2.2 23.7 1.2 2.4 1.0 4.1 2.8 3.4 7.9 1.7 8.5 3.7 5.9 5.2 6.8 32.1 9.1 7.5 0.8 1.2 6.6 1.8 1.9 17.7 5.5 3.4 3.5 7.7 3.0 0.1 8.2 2.4 3.1 15.1 3.4 8.8 3.5 3.5 10.8 6.1 2.2 2.0 1.0 1.5 14.4 1.9 6.5 3.9 1.0 1.9 1.3 1.3 1.5 1.0 1.7 1.2 1.8 1.3 PDHA1 PDHA ENSG00000131828 "Pyruvate dehydrogenase E1 alpha 1 subunit" P08559 X 19343893-19361705 "Citric acid cycle related proteins, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" "Carbohydrate metabolism, Glucose metabolism, Tricarboxylic acid cycle" Oxidoreductase "Disease mutation, Leigh syndrome, Primary mitochondrial disease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 107.3" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA047487, HPA047864, HPA063053" Approved Supported Mitochondria "Intracellular and membrane" 15000 Mitochondria "HPA047487: , HPA047864: , HPA063053: " "unprognostic (5.71e-3)" "unprognostic (2.46e-3)" "unprognostic (5.71e-2)" "unprognostic (3.36e-3)" "unprognostic (3.12e-2)" "unprognostic (2.27e-2)" "unprognostic (1.37e-2)" "unprognostic (4.28e-1)" "unprognostic (1.01e-1)" "unprognostic (7.01e-3)" "unprognostic (6.90e-2)" "unprognostic (8.68e-2)" "prognostic favourable (1.13e-7)" "unprognostic (3.72e-2)" "unprognostic (3.03e-1)" "unprognostic (1.92e-2)" "unprognostic (9.06e-2)" 22.5 16.1 14.7 11.7 24.3 20.4 14.7 18.6 25.0 12.3 28.6 13.0 27.7 22.7 13.0 21.6 17.2 12.4 11.8 89.3 15.5 12.2 36.6 26.6 10.5 8.9 14.8 19.9 12.2 28.7 25.0 11.6 14.9 19.0 10.8 28.2 12.7 41.8 18.3 107.3 12.7 21.1 21.2 12.7 11.5 24.9 6.3 12.0 11.3 15.0 44.9 14.9 13.1 12.4 39.4 45.1 34.8 46.1 35.5 36.6 31.9 25.7 32.1 23.3 24.5 22.6 17.3 28.6 17.8 15.9 37.0 28.6 45.7 16.6 44.1 13.2 21.4 33.7 71.4 30.9 39.0 14.6 39.8 21.9 55.3 40.2 24.0 34.9 17.9 22.3 28.8 34.1 33.8 22.4 19.2 18.7 25.8 34.1 29.1 35.9 23.7 56.2 30.1 39.0 54.0 63.6 26.4 12.9 13.7 28.4 36.0 32.2 38.0 24.5 13.9 19.1 17.2 52.0 22.5 15.9 16.4 29.2 18.0 24.5 16.5 34.8 35.0 24.2 30.3 46.1 36.6 39.4 29.4 32.8 45.1 29.3 29.0 30.6 6.1 35.5 39.1 29.8 31.1 31.9 14.7 24.3 18.6 25.0 15.5 12.2 14.8 19.9 19.0 12.0 PDHA2 PDHAL ENSG00000163114 "Pyruvate dehydrogenase E1 alpha 2 subunit" P29803 4 95840019-95841474 "Citric acid cycle related proteins, Enzymes, Predicted intracellular proteins" "Carbohydrate metabolism, Glucose metabolism, Tricarboxylic acid cycle" Oxidoreductase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 146 "testis: 60.5" "Cell line enhanced" "Detected in single" "BEWO: 1.1" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "HPA047487, HPA047864, HPA063053" Approved Supported Mitochondria Mitochondria "HPA047487: , HPA047864: , HPA063053: " 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 60.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 PDHB PDHE1B ENSG00000168291 "Pyruvate dehydrogenase E1 beta subunit" P11177 3 58427630-58433857 "Citric acid cycle related proteins, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" "Carbohydrate metabolism, Glucose metabolism, Tricarboxylic acid cycle" Oxidoreductase "Disease mutation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB033794, HPA036744, HPA036745" Enhanced Supported Nucleoplasm,Mitochondria 6500000 Mitochondria Nucleoplasm "CAB033794: AB_2162946, HPA036744: AB_10670921, HPA036745: AB_2675285" "unprognostic (2.06e-2)" "unprognostic (1.79e-1)" "unprognostic (6.04e-3)" "unprognostic (1.22e-1)" "unprognostic (7.22e-2)" "unprognostic (1.42e-1)" "unprognostic (3.20e-2)" "unprognostic (6.13e-2)" "unprognostic (9.62e-2)" "unprognostic (5.94e-2)" "unprognostic (3.98e-1)" "unprognostic (2.35e-1)" "prognostic favourable (2.79e-8)" "unprognostic (2.67e-1)" "unprognostic (8.37e-2)" "unprognostic (1.06e-2)" "unprognostic (9.85e-2)" 21.8 34.3 22.5 19.5 28.4 8.6 17.1 15.1 26.2 18.0 21.6 18.4 19.2 16.2 17.2 18.2 22.8 15.0 16.5 64.2 24.1 20.8 38.7 41.8 13.9 18.2 23.7 23.3 11.0 17.2 26.0 20.0 21.6 26.4 19.5 23.9 16.1 17.6 22.1 92.2 14.3 17.3 24.5 22.8 23.2 21.4 21.8 17.5 20.9 16.1 33.8 20.6 17.9 14.4 37.0 50.1 33.6 39.8 43.4 38.6 38.3 19.0 26.7 27.7 20.8 28.2 34.7 33.2 24.1 30.2 35.6 36.7 48.1 18.5 40.7 13.6 30.4 11.1 33.7 22.1 27.3 23.5 24.7 36.3 50.4 36.3 28.5 29.4 20.4 30.2 20.4 28.7 16.9 30.6 18.7 18.4 38.6 18.2 27.8 31.0 38.1 30.3 13.3 21.6 39.2 56.2 26.1 19.2 21.2 22.3 32.1 23.9 47.5 31.6 22.4 19.1 25.4 20.0 27.2 25.7 36.5 28.7 29.3 35.0 18.0 16.4 35.4 33.6 31.5 39.8 33.2 37.0 31.2 30.0 50.1 33.3 35.1 31.4 7.0 43.4 35.9 33.7 38.6 38.3 22.5 28.4 15.1 26.2 24.1 20.8 23.7 23.3 26.4 17.5 SDHA "FP, SDH2, SDHF" ENSG00000073578 "Succinate dehydrogenase complex flavoprotein subunit A" P31040 5 218241-256700 "Cancer-related genes, Citric acid cycle related proteins, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins" "Electron transport, Transport, Tricarboxylic acid cycle" Oxidoreductase "Cancer-related genes, Cardiomyopathy, Disease mutation, FDA approved drug targets, Leigh syndrome, Primary mitochondrial disease, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "heart muscle: 100.1;skeletal muscle: 114.0" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB034929, HPA041981, HPA064582" Enhanced Supported Nucleoli,Mitochondria 780000 Mitochondria Nucleoli "CAB034929: AB_2183443, HPA041981: AB_2677779, HPA064582: AB_2685293" "prognostic unfavourable (6.00e-4)" "unprognostic (1.93e-1)" "unprognostic (5.97e-2)" "unprognostic (1.36e-1)" "unprognostic (1.89e-1)" "unprognostic (1.62e-1)" "unprognostic (2.80e-1)" "unprognostic (3.14e-2)" "unprognostic (2.88e-1)" "unprognostic (1.67e-2)" "unprognostic (1.97e-1)" "unprognostic (1.24e-1)" "prognostic favourable (9.53e-8)" "unprognostic (1.11e-2)" "unprognostic (2.62e-1)" "unprognostic (3.57e-1)" "unprognostic (1.79e-1)" 17.6 31.4 15.3 11.5 20.3 10.6 12.8 18.8 29.0 10.2 29.4 17.3 10.0 44.3 11.3 12.1 15.3 12.6 14.8 100.1 15.8 14.5 36.5 55.4 10.7 11.7 19.6 19.3 14.5 14.7 23.2 9.5 9.2 29.7 10.7 24.6 14.5 17.3 12.0 114.0 11.5 39.9 16.5 13.2 13.9 21.2 14.6 14.8 15.7 12.5 39.6 12.5 13.2 11.1 28.3 31.9 29.1 29.2 27.1 48.9 32.4 18.4 29.9 12.3 20.1 21.2 15.9 33.4 14.2 18.1 24.5 25.0 32.4 25.1 22.8 45.0 16.2 23.9 21.7 29.0 14.5 48.6 19.9 11.6 82.6 42.0 13.1 14.4 15.1 15.8 18.7 18.3 9.7 26.5 18.6 19.0 11.5 28.2 19.1 39.0 4.2 37.9 24.7 17.9 44.2 52.2 24.5 13.6 7.8 67.0 43.3 17.6 26.3 18.3 19.2 18.2 17.9 10.8 11.7 20.2 8.6 16.8 17.6 20.9 11.5 17.8 24.4 29.1 36.4 29.2 32.1 28.3 34.8 35.1 31.9 24.5 34.5 31.7 5.9 27.1 24.1 20.5 48.9 32.4 15.3 20.3 18.8 29.0 15.8 14.5 19.6 19.3 29.7 14.8 SDHB "SDH, SDH1" ENSG00000117118 "Succinate dehydrogenase complex iron sulfur subunit B" P21912 1 17018722-17054170 "Cancer-related genes, Citric acid cycle related proteins, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Electron transport, Transport, Tricarboxylic acid cycle" Oxidoreductase "Cancer-related genes, Disease mutation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA002868, CAB009822, CAB068233, CAB068234, CAB068235" Enhanced Supported "Nucleoplasm,Plasma membrane,Mitochondria" "Intracellular and membrane" Mitochondria "Nucleoplasm, Plasma membrane" "CAB009822: AB_2183458, CAB068233: , CAB068234: , CAB068235: , HPA002868: AB_1079889" "unprognostic (1.06e-1)" "unprognostic (2.86e-2)" "unprognostic (2.19e-2)" "unprognostic (2.93e-2)" "unprognostic (1.88e-1)" "unprognostic (2.79e-3)" "unprognostic (1.58e-1)" "unprognostic (3.02e-1)" "unprognostic (1.19e-1)" "unprognostic (8.45e-2)" "unprognostic (5.51e-2)" "unprognostic (3.93e-2)" "prognostic favourable (2.93e-7)" "unprognostic (1.46e-1)" "unprognostic (2.75e-1)" "unprognostic (7.82e-2)" "unprognostic (3.82e-2)" 17.8 25.6 19.8 16.6 21.7 17.0 26.4 18.0 29.1 13.9 30.8 12.3 15.1 34.0 14.2 15.7 19.8 13.6 15.1 86.9 18.2 16.4 51.0 75.1 16.8 24.6 20.1 18.9 10.5 30.7 20.0 11.3 15.6 16.7 13.0 31.5 11.7 15.9 19.5 96.2 13.2 31.4 21.3 16.5 17.2 21.7 18.7 15.7 14.2 15.5 52.2 18.0 15.4 17.1 22.2 45.9 48.5 48.7 18.9 26.7 25.0 25.5 25.4 14.5 18.5 28.2 28.1 16.5 22.4 28.8 51.4 46.5 35.7 30.8 35.1 28.0 30.2 30.2 57.7 44.7 58.0 20.6 47.3 31.6 26.4 27.4 34.6 49.4 23.6 28.8 29.5 44.4 75.3 36.3 26.4 40.7 35.7 21.1 32.8 28.2 12.0 51.1 23.6 27.9 43.5 47.3 14.5 27.3 15.0 30.4 38.1 63.9 22.3 27.9 18.0 19.8 22.3 36.3 29.5 17.0 20.9 35.9 30.3 75.3 21.8 16.6 38.4 37.4 18.3 48.7 18.3 22.2 21.2 19.5 45.9 18.3 19.3 19.5 48.5 18.9 42.2 21.5 26.7 25.0 19.8 21.7 18.0 29.1 18.2 16.4 20.1 18.9 16.7 15.7 SDHD "cybS, PGL, PGL1" ENSG00000204370 "Succinate dehydrogenase complex subunit D" O14521 11 112086773-112120013 "Cancer-related genes, Citric acid cycle related proteins, Disease related genes, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Electron transport, Transport, Tricarboxylic acid cycle" "Cancer-related genes, Disease mutation, FDA approved drug targets, Primary mitochondrial disease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" HPA045727 Approved "Intracellular and membrane" "HPA045727: AB_10963114" "unprognostic (9.13e-2)" "unprognostic (3.51e-2)" "unprognostic (4.47e-3)" "unprognostic (4.21e-2)" "unprognostic (1.93e-1)" "unprognostic (4.98e-2)" "unprognostic (5.69e-2)" "unprognostic (2.50e-1)" "unprognostic (1.83e-3)" "unprognostic (7.10e-2)" "unprognostic (3.03e-2)" "unprognostic (1.80e-1)" "prognostic favourable (1.99e-10)" "unprognostic (5.14e-2)" "unprognostic (1.58e-2)" "unprognostic (1.56e-2)" "unprognostic (7.51e-2)" 20.9 23.1 17.1 21.7 19.4 10.9 19.6 14.1 18.4 18.1 33.6 14.2 23.9 36.0 22.7 17.5 35.2 17.3 17.9 42.5 15.1 13.7 66.6 75.4 19.1 23.3 17.1 15.1 18.6 23.2 22.5 16.1 20.1 18.0 23.7 33.9 15.7 32.6 21.7 65.4 15.5 61.2 24.0 15.3 22.8 22.2 8.8 14.8 21.7 46.2 33.9 24.6 23.5 20.3 55.5 74.7 62.1 91.7 46.1 53.7 68.9 16.8 17.3 11.8 17.9 44.2 35.5 19.8 20.6 29.3 21.6 27.1 59.9 44.3 30.7 63.7 27.7 42.4 36.8 29.1 26.5 27.2 18.5 29.2 12.9 31.8 34.4 45.9 22.2 39.1 32.3 25.7 41.2 30.4 30.1 42.4 26.7 21.2 27.5 41.5 16.0 43.0 25.5 31.4 57.2 44.2 41.3 17.1 11.3 28.9 39.0 20.5 40.1 33.1 23.7 21.1 27.7 23.4 18.9 12.6 16.1 56.2 12.0 60.2 20.1 46.1 73.0 48.7 41.4 91.7 44.1 55.5 44.5 43.1 74.7 45.6 53.7 49.8 62.1 46.1 70.7 36.8 44.2 68.9 17.1 19.4 14.1 18.4 15.1 13.7 17.1 15.1 18.0 14.8 SUCLA2 ENSG00000136143 "Succinate-CoA ligase ADP-forming beta subunit" Q9P2R7 13 47745736-48037968 "Citric acid cycle related proteins, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Tricarboxylic acid cycle" Ligase "Disease mutation, Primary mitochondrial disease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 89.0" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA039435, HPA039536, HPA061528" Enhanced Supported Enhanced Mitochondria 6600 Mitochondria "HPA039435: AB_10673144, HPA039536: AB_2676561, HPA061528: AB_2684553" "unprognostic (5.66e-3)" "unprognostic (1.72e-2)" "unprognostic (1.14e-1)" "unprognostic (8.76e-2)" "unprognostic (1.60e-1)" "unprognostic (3.45e-2)" "unprognostic (2.48e-1)" "unprognostic (1.71e-1)" "unprognostic (4.70e-2)" "unprognostic (1.41e-2)" "unprognostic (1.10e-1)" "unprognostic (1.38e-1)" "prognostic favourable (7.59e-14)" "unprognostic (3.53e-1)" "unprognostic (2.19e-1)" "unprognostic (2.29e-1)" "prognostic unfavourable (1.22e-4)" 21.6 18.5 19.2 8.6 22.1 5.2 17.5 29.7 32.4 15.3 15.7 11.7 15.6 24.5 12.7 12.1 14.6 11.3 9.4 42.1 20.0 21.6 34.0 12.9 7.9 11.4 22.6 19.1 14.4 10.8 19.8 14.9 12.2 28.7 16.2 16.5 8.9 13.9 14.8 89.0 10.0 22.7 14.7 18.3 9.7 12.3 8.0 15.4 15.6 16.9 25.6 10.2 11.0 12.6 17.1 29.5 12.4 25.0 23.4 25.2 17.2 17.2 20.0 25.4 15.2 29.1 22.0 15.3 26.4 29.6 27.5 18.7 35.5 19.6 24.2 20.2 25.8 24.0 33.5 25.1 34.9 23.1 28.7 27.2 19.0 23.0 20.3 27.5 15.9 20.7 29.6 18.7 22.1 20.2 18.3 8.8 27.3 11.9 28.3 31.5 26.3 25.6 24.1 23.2 18.7 39.7 16.7 14.1 16.8 22.0 20.4 15.5 18.1 24.4 15.4 15.3 9.9 21.7 18.3 9.1 14.2 28.2 9.5 20.1 22.4 5.7 24.5 12.4 17.6 25.0 21.2 17.1 19.7 21.6 29.5 16.3 25.2 24.9 4.5 23.4 20.0 24.3 21.6 17.2 19.2 22.1 29.7 32.4 20.0 21.6 22.6 19.1 28.7 15.4 SUCLG1 ENSG00000163541 "Succinate-CoA ligase alpha subunit" P53597 2 84423523-84460045 "Citric acid cycle related proteins, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Tricarboxylic acid cycle" Ligase "Disease mutation, Primary mitochondrial disease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "kidney: 125.6" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA036683, HPA036684" Enhanced Supported "Plasma membrane,Mitochondria" "Intracellular and membrane" 330000 Mitochondria "Plasma membrane" "HPA036683: AB_10671708, HPA036684: AB_2675248" "unprognostic (6.84e-3)" "unprognostic (7.16e-3)" "unprognostic (2.58e-3)" "prognostic unfavourable (5.23e-4)" "unprognostic (1.02e-1)" "unprognostic (2.11e-1)" "unprognostic (3.63e-2)" "unprognostic (3.49e-2)" "unprognostic (1.02e-1)" "unprognostic (2.00e-1)" "unprognostic (2.36e-2)" "unprognostic (9.24e-2)" "prognostic favourable (2.21e-8)" "unprognostic (4.94e-2)" "unprognostic (2.08e-1)" "unprognostic (2.81e-2)" "unprognostic (1.23e-1)" 26.1 23.3 18.0 15.0 18.9 10.6 23.8 18.9 19.5 14.1 50.1 17.7 23.2 53.9 13.9 19.6 25.0 13.5 14.0 57.7 17.4 17.3 125.6 44.1 12.8 13.3 19.2 17.0 12.7 33.9 36.2 16.3 13.8 17.3 17.1 39.4 16.9 39.3 24.9 57.6 15.6 71.6 26.5 17.1 12.1 21.9 13.3 16.0 16.9 28.8 42.8 15.2 24.3 16.3 26.6 43.5 31.6 40.3 35.2 39.1 46.8 23.5 25.9 20.5 25.0 38.6 26.0 35.5 26.9 23.0 34.6 25.3 59.3 19.5 32.4 18.6 32.1 34.4 42.1 31.6 41.2 31.3 38.3 28.1 22.4 33.7 32.6 28.6 23.0 30.9 26.0 29.1 39.8 30.8 28.5 26.7 31.5 36.0 40.6 26.2 10.7 46.4 25.8 47.5 35.5 46.4 28.6 24.9 13.9 21.4 44.5 42.7 27.1 22.6 24.8 27.2 26.3 33.3 32.9 23.5 33.3 28.0 31.7 39.7 23.9 31.6 34.4 28.7 31.4 40.3 34.6 26.6 29.2 35.1 43.5 20.2 32.4 34.2 18.5 35.2 40.0 23.7 39.1 46.8 18.0 18.9 18.9 19.5 17.4 17.3 19.2 17.0 17.3 16.0 SUCLG2 ENSG00000172340 "Succinate-CoA ligase GDP-forming beta subunit" Q96I99 3 67360460-67654614 "Citric acid cycle related proteins, Enzymes, Plasma proteins, Predicted intracellular proteins" "Tricarboxylic acid cycle" Ligase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 90.9" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA046705, HPA051998" Enhanced Supported "Plasma membrane,Mitochondria" 290000 "Plasma membrane, Mitochondria" "HPA046705: AB_2679762, HPA051998: AB_2681687" "unprognostic (1.69e-1)" "unprognostic (2.31e-1)" "prognostic favourable (1.08e-4)" "unprognostic (2.12e-1)" "unprognostic (3.10e-1)" "unprognostic (5.32e-2)" "unprognostic (1.87e-2)" "unprognostic (1.69e-1)" "unprognostic (3.88e-1)" "unprognostic (3.26e-2)" "unprognostic (4.61e-3)" "unprognostic (5.59e-2)" "prognostic favourable (2.79e-10)" "unprognostic (3.08e-2)" "unprognostic (2.79e-1)" "unprognostic (1.07e-1)" "unprognostic (1.38e-1)" 17.0 19.3 8.8 26.5 10.0 3.4 12.4 2.4 7.2 15.3 38.9 9.5 16.4 31.4 11.5 18.3 18.6 9.9 27.9 23.6 6.6 6.2 38.3 90.9 14.6 21.1 9.8 6.5 16.5 20.9 5.9 8.5 8.5 7.6 14.0 34.5 9.6 21.0 17.3 57.0 9.3 42.4 23.5 8.6 24.7 25.4 6.5 8.1 9.6 16.4 27.0 16.7 19.9 13.2 19.2 10.2 5.8 18.2 27.1 31.1 18.9 13.8 12.1 12.0 14.6 20.2 35.1 14.7 16.6 24.4 19.6 21.9 13.4 31.0 17.7 5.4 23.4 7.1 9.3 23.0 25.5 7.5 6.4 16.1 11.0 20.8 26.1 21.1 11.3 26.2 20.0 15.3 35.3 20.8 12.2 16.3 42.6 9.7 7.9 6.7 11.2 7.5 5.5 18.6 26.5 33.2 21.6 2.3 8.2 26.4 30.6 22.0 23.5 13.6 18.1 19.5 12.8 21.4 19.7 11.1 16.2 12.5 28.6 16.5 22.9 5.8 15.3 5.2 13.8 18.2 16.7 19.2 20.0 17.4 10.2 16.7 31.1 23.7 0.7 27.1 14.8 4.0 18.5 18.9 8.8 10.0 2.4 7.2 6.6 6.2 9.8 6.5 7.6 8.1