Gene "Gene synonym" Ensembl "Gene description" Uniprot Chromosome Position "Protein class" "Biological process" "Molecular function" "Disease involvement" Evidence "HPA evidence" "UniProt evidence" "NeXtProt evidence" "MS evidence" "RNA tissue specificity" "RNA tissue distribution" "RNA tissue specificity score" "RNA tissue specific NX" "RNA cell line specificity" "RNA cell line distribution" "RNA cell line specificity score" "RNA cell line specific NX" "RNA cancer specificity" "RNA cancer distribution" "RNA cancer specificity score" "RNA cancer specific FPKM" "RNA brain regional specificity" "RNA brain regional distribution" "RNA brain regional specificity score" "RNA brain regional specific NX" "RNA blood cell specificity" "RNA blood cell distribution" "RNA blood cell specificity score" "RNA blood cell specific NX" "RNA blood lineage specificity" "RNA blood lineage distribution" "RNA blood lineage specificity score" "RNA blood lineage specific NX" "RNA mouse brain regional specificity" "RNA mouse brain regional distribution" "RNA mouse brain regional specificity score" "RNA mouse brain regional specific pTPM" "RNA pig brain regional specificity" "RNA pig brain regional distribution" "RNA pig brain regional specificity score" "RNA pig brain regional specific pTPM" Antibody "Reliability (IH)" "Reliability (Mouse Brain)" "Reliability (IF)" "Subcellular location" "Secretome location" "Blood concentration - Conc. blood IM [pg/L]" "Blood concentration - Conc. blood MS [pg/L]" "Subcellular main location" "Subcellular additional location" "Antibody RRID" "Pathology prognostics - Breast cancer" "Pathology prognostics - Cervical cancer" "Pathology prognostics - Colorectal cancer" "Pathology prognostics - Endometrial cancer" "Pathology prognostics - Glioma" "Pathology prognostics - Head and neck cancer" "Pathology prognostics - Liver cancer" "Pathology prognostics - Lung cancer" "Pathology prognostics - Melanoma" "Pathology prognostics - Ovarian cancer" "Pathology prognostics - Pancreatic cancer" "Pathology prognostics - Prostate cancer" "Pathology prognostics - Renal cancer" "Pathology prognostics - Stomach cancer" "Pathology prognostics - Testis cancer" "Pathology prognostics - Thyroid cancer" "Pathology prognostics - Urothelial cancer" "Tissue RNA - adipose tissue [NX]" "Tissue RNA - adrenal gland [NX]" "Tissue RNA - amygdala [NX]" "Tissue RNA - appendix [NX]" "Tissue RNA - basal ganglia [NX]" "Tissue RNA - bone marrow [NX]" "Tissue RNA - breast [NX]" "Tissue RNA - cerebellum [NX]" "Tissue RNA - cerebral cortex [NX]" "Tissue RNA - cervix, uterine [NX]" "Tissue RNA - colon [NX]" "Tissue RNA - corpus callosum [NX]" "Tissue RNA - ductus deferens [NX]" "Tissue RNA - duodenum [NX]" "Tissue RNA - endometrium 1 [NX]" "Tissue RNA - epididymis [NX]" "Tissue RNA - esophagus [NX]" "Tissue RNA - fallopian tube [NX]" "Tissue RNA - gallbladder [NX]" "Tissue RNA - heart muscle [NX]" "Tissue RNA - hippocampal formation [NX]" "Tissue RNA - hypothalamus [NX]" "Tissue RNA - kidney [NX]" "Tissue RNA - liver [NX]" "Tissue RNA - lung [NX]" "Tissue RNA - lymph node [NX]" "Tissue RNA - midbrain [NX]" "Tissue RNA - olfactory region [NX]" "Tissue RNA - ovary [NX]" "Tissue RNA - pancreas [NX]" "Tissue RNA - parathyroid gland [NX]" "Tissue RNA - pituitary gland [NX]" "Tissue RNA - placenta [NX]" "Tissue RNA - pons and medulla [NX]" "Tissue RNA - prostate [NX]" "Tissue RNA - rectum [NX]" "Tissue RNA - retina [NX]" "Tissue RNA - salivary gland [NX]" "Tissue RNA - seminal vesicle [NX]" "Tissue RNA - skeletal muscle [NX]" "Tissue RNA - skin 1 [NX]" "Tissue RNA - small intestine [NX]" "Tissue RNA - smooth muscle [NX]" "Tissue RNA - spinal cord [NX]" "Tissue RNA - spleen [NX]" "Tissue RNA - stomach 1 [NX]" "Tissue RNA - testis [NX]" "Tissue RNA - thalamus [NX]" "Tissue RNA - thymus [NX]" "Tissue RNA - thyroid gland [NX]" "Tissue RNA - tongue [NX]" "Tissue RNA - tonsil [NX]" "Tissue RNA - urinary bladder [NX]" "Tissue RNA - vagina [NX]" "Tissue RNA - B-cells [NX]" "Tissue RNA - dendritic cells [NX]" "Tissue RNA - granulocytes [NX]" "Tissue RNA - monocytes [NX]" "Tissue RNA - NK-cells [NX]" "Tissue RNA - T-cells [NX]" "Tissue RNA - total PBMC [NX]" "Cell RNA - A-431 [NX]" "Cell RNA - A549 [NX]" "Cell RNA - AF22 [NX]" "Cell RNA - AN3-CA [NX]" "Cell RNA - ASC diff [NX]" "Cell RNA - ASC TERT1 [NX]" "Cell RNA - BEWO [NX]" "Cell RNA - BJ [NX]" "Cell RNA - BJ hTERT+ [NX]" "Cell RNA - BJ hTERT+ SV40 Large T+ [NX]" "Cell RNA - BJ hTERT+ SV40 Large T+ RasG12V [NX]" "Cell RNA - CACO-2 [NX]" "Cell RNA - CAPAN-2 [NX]" "Cell RNA - Daudi [NX]" "Cell RNA - EFO-21 [NX]" "Cell RNA - fHDF/TERT166 [NX]" "Cell RNA - HaCaT [NX]" "Cell RNA - HAP1 [NX]" "Cell RNA - HBEC3-KT [NX]" "Cell RNA - HBF TERT88 [NX]" "Cell RNA - HDLM-2 [NX]" "Cell RNA - HEK 293 [NX]" "Cell RNA - HEL [NX]" "Cell RNA - HeLa [NX]" "Cell RNA - Hep G2 [NX]" "Cell RNA - HHSteC [NX]" "Cell RNA - HL-60 [NX]" "Cell RNA - HMC-1 [NX]" "Cell RNA - HSkMC [NX]" "Cell RNA - hTCEpi [NX]" "Cell RNA - hTEC/SVTERT24-B [NX]" "Cell RNA - hTERT-HME1 [NX]" "Cell RNA - HUVEC TERT2 [NX]" "Cell RNA - K-562 [NX]" "Cell RNA - Karpas-707 [NX]" "Cell RNA - LHCN-M2 [NX]" "Cell RNA - MCF7 [NX]" "Cell RNA - MOLT-4 [NX]" "Cell RNA - NB-4 [NX]" "Cell RNA - NTERA-2 [NX]" "Cell RNA - PC-3 [NX]" "Cell RNA - REH [NX]" "Cell RNA - RH-30 [NX]" "Cell RNA - RPMI-8226 [NX]" "Cell RNA - RPTEC TERT1 [NX]" "Cell RNA - RT4 [NX]" "Cell RNA - SCLC-21H [NX]" "Cell RNA - SH-SY5Y [NX]" "Cell RNA - SiHa [NX]" "Cell RNA - SK-BR-3 [NX]" "Cell RNA - SK-MEL-30 [NX]" "Cell RNA - T-47d [NX]" "Cell RNA - THP-1 [NX]" "Cell RNA - TIME [NX]" "Cell RNA - U-138 MG [NX]" "Cell RNA - U-2 OS [NX]" "Cell RNA - U-2197 [NX]" "Cell RNA - U-251 MG [NX]" "Cell RNA - U-266/70 [NX]" "Cell RNA - U-266/84 [NX]" "Cell RNA - U-698 [NX]" "Cell RNA - U-87 MG [NX]" "Cell RNA - U-937 [NX]" "Cell RNA - WM-115 [NX]" "Blood RNA - basophil [NX]" "Blood RNA - classical monocyte [NX]" "Blood RNA - eosinophil [NX]" "Blood RNA - gdT-cell [NX]" "Blood RNA - intermediate monocyte [NX]" "Blood RNA - MAIT T-cell [NX]" "Blood RNA - memory B-cell [NX]" "Blood RNA - memory CD4 T-cell [NX]" "Blood RNA - memory CD8 T-cell [NX]" "Blood RNA - myeloid DC [NX]" "Blood RNA - naive B-cell [NX]" "Blood RNA - naive CD4 T-cell [NX]" "Blood RNA - naive CD8 T-cell [NX]" "Blood RNA - neutrophil [NX]" "Blood RNA - NK-cell [NX]" "Blood RNA - non-classical monocyte [NX]" "Blood RNA - plasmacytoid DC [NX]" "Blood RNA - T-reg [NX]" "Blood RNA - total PBMC [NX]" "Brain RNA - amygdala [NX]" "Brain RNA - basal ganglia [NX]" "Brain RNA - cerebellum [NX]" "Brain RNA - cerebral cortex [NX]" "Brain RNA - hippocampal formation [NX]" "Brain RNA - hypothalamus [NX]" "Brain RNA - midbrain [NX]" "Brain RNA - olfactory region [NX]" "Brain RNA - pons and medulla [NX]" "Brain RNA - thalamus [NX]" MAP2K1 "MAPKK1, MEK1, PRKMK1" ENSG00000169032 "Mitogen-activated protein kinase kinase 1" Q02750 15 66386817-66492312 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Predicted intracellular proteins, RAS pathway related proteins" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Cardiomyopathy, Disease mutation, Ectodermal dysplasia, FDA approved drug targets, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB003834, HPA026430" Approved Enhanced "Plasma membrane,Cytosol" 62000 "Plasma membrane, Cytosol" "CAB003834: AB_562310, HPA026430: AB_1853742" "unprognostic (4.05e-2)" "unprognostic (1.23e-2)" "unprognostic (2.07e-1)" "unprognostic (4.92e-2)" "prognostic unfavourable (1.95e-4)" "unprognostic (1.81e-3)" "unprognostic (5.78e-2)" "unprognostic (9.91e-3)" "unprognostic (1.11e-1)" "unprognostic (1.77e-1)" "unprognostic (1.45e-1)" "unprognostic (7.62e-3)" "unprognostic (1.20e-1)" "unprognostic (2.71e-1)" "unprognostic (1.96e-1)" "unprognostic (1.15e-1)" "unprognostic (9.40e-3)" 28.6 16.9 33.9 19.1 54.1 29.0 23.6 32.5 48.4 12.5 12.1 8.4 10.2 10.0 11.8 16.5 22.0 10.6 14.4 19.1 49.2 26.4 15.3 53.1 16.4 23.3 17.6 31.2 13.5 11.7 23.4 12.0 15.4 17.2 14.4 12.9 9.1 13.2 12.4 39.5 12.3 10.9 16.9 17.4 14.5 10.8 7.8 12.6 12.6 12.3 9.7 27.9 13.6 18.7 4.6 16.2 5.5 8.2 8.4 7.9 2.7 33.1 15.6 31.5 13.1 19.0 14.3 18.2 24.1 20.6 26.2 23.4 23.5 27.3 30.5 29.9 19.8 29.6 29.4 35.2 30.8 24.5 17.5 9.8 16.4 12.7 15.4 12.9 14.6 11.0 21.8 18.9 28.1 20.4 17.3 39.0 38.1 12.8 10.3 16.8 16.1 13.7 11.7 19.5 27.1 25.4 14.3 19.4 10.8 19.5 15.3 20.2 13.8 11.0 28.1 34.1 20.9 24.0 35.7 24.2 43.0 19.4 36.0 22.8 15.9 3.2 8.2 5.5 7.4 8.2 6.7 3.0 6.6 6.9 8.3 4.6 7.9 4.9 3.9 8.4 7.3 16.2 4.9 2.7 33.9 54.1 32.5 46.9 49.2 26.4 17.6 31.2 17.2 12.6 MAP2K2 "MEK2, PRKMK2" ENSG00000126934 "Mitogen-activated protein kinase kinase 2" P36507 19 4090321-4124129 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Predicted intracellular proteins, RAS pathway related proteins" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Cardiomyopathy, Disease mutation, Ectodermal dysplasia, FDA approved drug targets, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "CAB003835, HPA051993" Supported Supported Cytosol Cytosol "CAB003835: AB_562312, HPA051993: " "unprognostic (4.39e-1)" "prognostic favourable (3.72e-4)" "unprognostic (4.24e-1)" "unprognostic (1.26e-3)" "unprognostic (2.58e-1)" "prognostic favourable (7.98e-4)" "unprognostic (2.08e-3)" "unprognostic (2.11e-1)" "unprognostic (2.65e-1)" "unprognostic (1.06e-1)" "unprognostic (7.45e-3)" "unprognostic (4.95e-2)" "unprognostic (1.32e-1)" "prognostic favourable (5.43e-5)" "unprognostic (2.91e-2)" "unprognostic (2.25e-1)" "unprognostic (4.90e-2)" 23.9 33.0 35.6 27.6 36.1 46.7 30.2 31.2 43.4 22.6 38.8 24.6 27.0 70.9 21.8 23.2 32.8 21.7 27.9 41.4 33.1 31.0 22.7 42.0 24.1 44.5 34.4 29.2 30.8 46.0 18.9 29.7 21.3 26.1 25.7 24.3 21.7 41.5 24.0 134.9 27.4 56.7 19.0 25.2 25.9 28.3 42.0 20.9 44.1 26.2 42.2 29.1 20.0 26.9 11.4 10.7 28.3 10.6 11.3 12.1 4.5 36.2 40.0 21.9 30.7 30.3 36.6 21.9 23.9 32.0 32.7 29.7 34.6 19.7 31.0 22.6 27.2 26.2 17.1 25.5 25.4 26.3 20.8 11.3 21.8 38.2 46.5 20.8 23.9 40.4 24.9 22.9 30.6 28.9 21.6 61.3 27.5 45.4 41.1 29.2 25.1 29.1 31.5 14.4 35.4 28.5 23.3 29.7 29.6 21.9 30.4 74.5 23.4 35.7 25.5 26.9 23.3 68.6 36.8 61.7 37.3 21.7 41.7 37.5 45.9 15.2 9.1 28.3 11.9 10.6 9.7 8.9 9.7 12.1 10.7 11.4 8.9 11.6 14.4 11.3 8.7 6.0 9.2 4.5 35.6 36.1 31.2 43.4 33.1 31.0 34.4 29.2 26.1 20.9 MAP2K3 "MAPKK3, MEK3, MKK3, PRKMK3" ENSG00000034152 "Mitogen-activated protein kinase kinase 3" P46734 17 21284672-21315240 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Disease mutation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" CAB018548 Approved Supported Nucleoplasm,Cytosol "Nucleoplasm, Cytosol" "CAB018548: AB_631927" "unprognostic (2.31e-1)" "unprognostic (6.39e-2)" "unprognostic (4.63e-2)" "unprognostic (3.68e-1)" "unprognostic (3.54e-3)" "unprognostic (1.60e-1)" "unprognostic (2.97e-2)" "unprognostic (1.35e-2)" "unprognostic (5.25e-3)" "unprognostic (1.88e-2)" "unprognostic (3.16e-2)" "unprognostic (2.18e-2)" "unprognostic (1.33e-1)" "unprognostic (6.48e-2)" "unprognostic (1.22e-2)" "unprognostic (2.92e-1)" "unprognostic (1.77e-1)" 16.1 12.1 5.5 14.8 7.3 66.9 29.0 12.4 8.9 10.2 12.4 6.3 10.3 18.1 7.6 11.1 24.2 11.6 25.1 26.8 5.6 5.3 15.8 37.1 25.5 34.0 7.4 3.9 10.1 26.3 9.6 15.8 26.7 9.5 12.2 9.3 12.7 18.5 9.2 46.4 20.9 23.8 18.1 7.6 26.7 16.3 5.3 4.1 16.4 11.5 45.0 21.4 16.0 17.3 13.2 17.3 49.2 33.3 5.4 16.2 10.0 21.6 22.0 2.9 13.3 17.8 11.4 11.1 33.6 36.5 26.8 24.7 24.3 14.0 19.6 13.7 52.5 21.5 9.3 29.8 19.1 20.3 17.0 11.4 12.6 22.0 5.5 14.9 23.4 8.8 8.5 36.5 11.0 12.0 2.2 9.8 22.3 21.5 7.4 14.2 8.4 12.6 15.5 18.9 14.5 15.1 22.9 8.0 2.8 12.4 13.4 23.3 6.7 5.1 10.9 25.5 20.8 27.2 21.6 12.3 6.2 25.2 24.6 12.9 13.1 14.5 16.0 25.2 14.6 24.0 12.6 13.2 12.1 13.6 17.3 10.6 7.8 10.1 49.2 5.4 33.3 12.7 16.2 10.0 5.5 7.3 12.4 8.9 5.6 5.3 7.4 3.9 9.5 4.1 MAP2K4 "JNKK1, MEK4, MKK4, PRKMK4, SERK1" ENSG00000065559 "Mitogen-activated protein kinase kinase 4" P45985 17 12020824-12143830 "Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins" "Apoptosis, Stress response" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Cell type enhanced" "Detected in many" "neutrophil: 13.2" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB007751, HPA060074" Enhanced Approved "Nucleoplasm,Cell Junctions" Nucleoplasm "Cell Junctions" "CAB007751: , HPA060074: " "unprognostic (1.55e-1)" "unprognostic (1.85e-1)" "unprognostic (4.47e-2)" "unprognostic (1.02e-2)" "unprognostic (1.04e-1)" "unprognostic (2.70e-1)" "unprognostic (2.89e-1)" "unprognostic (2.16e-1)" "unprognostic (1.93e-3)" "unprognostic (2.53e-1)" "unprognostic (2.76e-3)" "unprognostic (4.82e-2)" "unprognostic (5.32e-3)" "unprognostic (3.13e-1)" "unprognostic (2.30e-1)" "unprognostic (7.00e-2)" "unprognostic (1.79e-1)" 10.7 13.2 23.7 9.4 21.0 3.1 14.4 25.0 42.7 12.5 11.5 7.9 8.5 9.6 12.1 17.8 18.5 11.5 10.7 14.9 31.7 29.3 15.8 20.6 11.4 14.6 24.5 27.1 13.0 11.1 19.6 16.7 15.1 23.4 14.5 13.1 6.5 9.8 13.2 20.6 14.4 9.9 13.5 16.3 10.7 10.7 10.3 9.8 10.3 16.5 11.6 13.4 11.1 11.2 2.8 1.8 13.2 4.3 3.5 3.3 2.3 17.9 15.5 20.4 10.5 11.3 14.7 13.0 12.3 16.2 14.0 13.4 9.2 6.2 7.5 10.0 19.1 12.1 17.7 17.1 21.1 13.2 20.8 8.3 9.1 17.3 13.3 7.9 12.6 12.1 17.0 16.4 17.2 12.7 8.8 4.4 17.6 6.7 9.6 7.4 11.9 7.6 11.8 22.9 5.1 19.2 11.6 4.1 12.1 14.2 7.6 11.8 9.6 5.8 11.6 6.9 10.7 9.5 14.5 8.7 9.7 5.9 13.0 6.3 10.0 0.6 2.7 2.0 3.0 1.5 2.7 2.8 2.4 2.4 1.8 2.7 2.0 3.3 13.2 3.5 4.3 1.8 2.6 2.3 23.7 21.0 25.0 42.7 31.7 29.3 24.5 27.1 23.4 9.8 MAP2K5 "HsT17454, MAPKK5, MEK5, PRKMK5" ENSG00000137764 "Mitogen-activated protein kinase kinase 5" Q13163 15 67542709-67807123 "Enzymes, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB022094, HPA027347, HPA027755" Supported Approved Nucleoli,Microtubules "Nucleoli, Microtubules" "CAB022094: , HPA027347: AB_10599290, HPA027755: AB_10600883" "unprognostic (4.54e-2)" "unprognostic (1.87e-2)" "unprognostic (4.16e-2)" "unprognostic (9.06e-2)" "unprognostic (1.77e-3)" "unprognostic (1.06e-1)" "unprognostic (1.96e-1)" "unprognostic (3.73e-1)" "unprognostic (2.41e-2)" "unprognostic (2.83e-1)" "unprognostic (1.47e-2)" "unprognostic (5.41e-2)" "prognostic favourable (8.03e-5)" "unprognostic (1.68e-1)" "unprognostic (2.74e-1)" "unprognostic (3.99e-2)" "unprognostic (2.73e-2)" 18.6 22.2 20.3 13.8 30.9 14.6 23.7 25.0 25.4 17.0 19.3 17.2 19.9 14.7 17.4 11.3 13.5 16.2 14.4 18.8 17.1 16.4 14.2 15.5 13.5 27.9 12.6 11.5 29.0 21.0 34.1 14.4 17.7 22.2 15.9 14.8 15.6 15.7 18.5 28.5 18.7 15.0 19.4 17.2 13.0 15.4 20.3 16.2 40.2 16.9 9.2 11.9 17.0 17.9 6.6 10.2 10.3 7.3 11.7 11.2 5.5 5.5 14.6 8.8 10.3 13.0 22.8 6.9 5.5 11.2 10.4 11.4 5.8 9.9 9.1 11.7 9.2 8.3 14.9 8.8 8.6 13.1 14.9 12.3 10.9 6.3 16.4 7.4 7.7 15.6 11.7 7.5 17.1 13.7 10.8 15.2 8.6 7.1 12.1 8.8 12.3 7.1 12.0 10.2 15.1 6.3 10.1 5.5 8.6 6.2 9.2 22.0 11.5 14.6 11.4 10.7 7.1 7.4 7.4 21.5 25.3 10.6 14.4 17.0 7.7 10.3 7.3 6.6 7.7 5.6 11.2 6.6 7.3 9.0 10.2 6.2 10.4 9.5 1.7 11.7 6.2 3.9 7.4 5.5 20.3 30.9 25.0 25.4 17.1 16.4 12.6 11.5 22.2 16.2 MAP2K6 "MAPKK6, MEK6, MKK6, PRKMK6, SAPKK3" ENSG00000108984 "Mitogen-activated protein kinase kinase 6" P52564 17 69414698-69553861 "Enzymes, Predicted intracellular proteins" "Apoptosis, Stress response, Transcription, Transcription regulation" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "blood: 31.9;skeletal muscle: 55.6" "Cell line enhanced" "Detected in many" "A549: 23.9;HUVEC TERT2: 17.2" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 7 "classical monocyte: 9.3;neutrophil: 19.3;plasmacytoid DC: 31.9" "Group enriched" "Detected in all" 9 "dendritic cells: 31.9;granulocytes: 19.3;monocytes: 9.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB007744, HPA031134" Enhanced Supported Nucleoplasm,Cytosol "Nucleoplasm, Cytosol" "CAB007744: AB_562318, HPA031134: AB_10603016" "prognostic favourable (2.27e-6)" "unprognostic (2.24e-1)" "unprognostic (8.46e-2)" "unprognostic (4.10e-2)" "unprognostic (3.75e-2)" "unprognostic (1.23e-1)" "unprognostic (7.61e-3)" "unprognostic (9.52e-2)" "unprognostic (3.67e-1)" "unprognostic (4.09e-3)" "prognostic favourable (7.52e-4)" "unprognostic (3.61e-2)" "unprognostic (2.29e-2)" "unprognostic (7.48e-2)" "unprognostic (9.43e-2)" "unprognostic (1.39e-1)" "unprognostic (2.03e-2)" 4.5 2.0 3.2 8.6 5.9 10.1 14.0 13.7 7.5 19.8 21.5 6.2 4.7 7.2 4.7 3.1 3.4 3.3 5.1 2.5 3.9 3.5 4.1 8.6 2.6 10.3 5.4 4.1 2.7 8.5 0.0 3.2 1.1 5.3 2.8 22.8 5.3 4.0 4.6 55.6 2.3 7.3 2.3 6.2 5.9 5.4 2.1 5.4 13.7 2.8 4.8 5.1 3.0 2.5 2.3 31.9 19.3 9.3 1.8 2.1 2.6 0.1 23.9 10.8 13.0 4.7 2.5 1.6 0.1 3.5 1.0 1.5 0.7 1.1 0.6 8.8 0.5 1.2 3.7 0.5 0.3 0.8 1.9 0.1 6.7 6.7 4.6 1.0 0.9 11.9 0.3 0.3 0.0 17.2 0.0 1.7 0.0 0.1 12.5 0.4 7.6 4.4 4.5 1.1 0.3 4.8 3.3 4.8 7.3 1.0 0.9 2.2 3.3 1.3 3.0 1.3 1.5 1.1 0.4 1.2 1.3 0.3 1.0 1.5 1.0 0.8 9.3 1.6 1.2 1.1 2.1 1.6 1.4 1.5 2.9 2.3 1.6 1.5 19.3 1.8 0.4 31.9 1.9 2.6 3.2 5.9 13.7 7.5 3.9 3.5 5.4 4.1 5.3 5.4 MAP2K7 "Jnkk2, MKK7, PRKMK7" ENSG00000076984 "Mitogen-activated protein kinase kinase 7" O14733 19 7903843-7914478 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Apoptosis, Stress response" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA001633, CAB004262, HPA064711" Supported Approved "Golgi apparatus,Plasma membrane,Cytosol" "Plasma membrane, Cytosol" "Golgi apparatus" "CAB004262: AB_627925, HPA001633: AB_1079516, HPA064711: " "unprognostic (1.77e-1)" "unprognostic (5.04e-2)" "unprognostic (1.06e-2)" "unprognostic (2.16e-1)" "unprognostic (4.24e-2)" "prognostic favourable (8.54e-5)" "unprognostic (1.80e-3)" "unprognostic (2.55e-1)" "unprognostic (2.69e-2)" "unprognostic (1.69e-2)" "unprognostic (1.27e-3)" "unprognostic (1.56e-1)" "unprognostic (3.54e-2)" "unprognostic (3.71e-2)" "unprognostic (6.05e-2)" "unprognostic (1.73e-2)" "prognostic favourable (1.56e-4)" 16.3 14.9 13.5 16.4 16.4 23.8 13.6 28.7 21.5 14.3 15.6 23.2 15.1 19.3 19.1 9.9 13.6 13.1 14.3 15.8 14.6 11.9 12.8 15.9 12.5 15.9 17.2 13.9 18.4 22.3 13.9 17.0 16.4 16.2 14.4 7.9 14.2 23.0 13.4 61.6 21.3 18.7 14.1 12.5 19.4 14.8 21.5 16.5 9.8 13.7 17.3 12.8 15.4 15.2 3.0 2.6 4.8 2.7 3.3 2.5 1.0 12.7 7.3 6.4 10.4 5.1 5.0 11.9 8.4 4.1 5.7 6.0 10.5 7.8 15.2 13.6 4.4 11.7 5.5 6.4 2.2 12.1 27.4 10.7 9.7 7.8 6.6 9.9 13.6 5.7 8.4 4.5 5.2 5.2 15.6 20.0 3.3 6.7 14.2 24.2 11.2 16.5 14.1 6.9 15.4 5.1 10.7 11.7 11.8 5.7 10.1 11.7 10.8 11.4 7.7 17.5 10.0 12.3 11.3 29.0 13.4 14.3 8.7 14.7 7.0 0.0 2.7 1.9 2.3 2.5 1.5 2.1 1.9 2.0 1.3 3.0 1.7 2.5 4.8 3.3 1.5 2.6 0.7 1.0 13.5 16.4 28.7 21.5 14.6 11.9 17.2 13.9 16.2 16.5 MAP3K1 "MAPKKK1, MEKK, MEKK1" ENSG00000095015 "Mitogen-activated protein kinase kinase kinase 1" Q13233 5 56815574-56896152 "Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted membrane proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell line enhanced" "Detected in many" "SH-SY5Y: 27.0;THP-1: 25.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Region enriched" "Detected in many" 6 "olfactory region: 22.5" "Low region specificity" "Detected in all" "CAB004500, HPA046509" Approved Approved Cytosol Cytosol "CAB004500: AB_627926, HPA046509: " "unprognostic (1.77e-1)" "unprognostic (1.71e-2)" "unprognostic (4.09e-1)" "unprognostic (2.18e-1)" "unprognostic (3.48e-2)" "unprognostic (5.39e-3)" "unprognostic (5.20e-3)" "unprognostic (2.52e-2)" "unprognostic (1.35e-1)" "unprognostic (1.41e-1)" "unprognostic (1.05e-2)" "unprognostic (6.73e-2)" "unprognostic (1.97e-3)" "unprognostic (2.18e-2)" "unprognostic (1.58e-1)" "unprognostic (9.92e-3)" "unprognostic (1.11e-1)" 6.7 4.9 5.4 14.6 4.8 15.2 14.9 8.0 4.5 7.6 6.7 5.4 7.3 4.3 7.1 9.4 12.7 7.2 5.9 4.3 3.7 3.2 9.5 4.4 8.8 21.4 6.4 3.1 8.4 9.2 6.3 7.9 8.1 4.5 8.3 4.5 12.6 15.4 9.7 3.5 21.8 11.2 4.0 3.8 21.3 5.5 8.5 5.1 11.7 19.2 6.6 18.2 6.0 11.7 6.6 2.8 6.7 7.2 2.7 5.8 2.3 6.4 3.9 6.2 4.1 1.0 0.8 10.4 1.2 1.7 3.9 5.5 18.4 4.9 5.8 0.4 1.5 3.4 5.1 2.3 5.4 2.0 2.2 3.2 1.7 8.6 2.5 5.1 9.0 1.0 2.5 1.2 1.9 1.7 2.8 10.5 1.0 2.8 3.5 6.9 2.8 0.5 5.6 4.4 19.9 6.8 6.8 2.6 27.0 3.8 4.8 11.0 13.2 25.2 4.9 0.3 3.3 1.4 2.3 7.7 3.9 11.1 0.6 3.0 6.6 6.7 4.5 1.0 1.2 6.8 1.2 6.6 3.8 1.8 2.8 5.1 2.5 0.9 2.6 2.7 7.2 1.5 5.8 2.3 5.4 4.8 8.0 4.5 3.7 3.2 6.4 3.1 4.5 5.1 MAP3K10 "MEKK10, MLK2, MST" ENSG00000130758 "Mitogen-activated protein kinase kinase kinase 10" Q02779 19 40191744-40215575 "Enzymes, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 32.0" "Low cell line specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA007039 Approved Approved "Nucleoplasm,Actin filaments,Cytosol" "Nucleoplasm, Actin filaments, Cytosol" "HPA007039: AB_1079357" "unprognostic (2.09e-1)" "unprognostic (3.77e-2)" "unprognostic (1.42e-3)" "unprognostic (2.03e-2)" "unprognostic (2.04e-1)" "prognostic favourable (8.69e-4)" "unprognostic (4.50e-3)" "unprognostic (1.80e-1)" "unprognostic (3.94e-2)" "unprognostic (6.13e-2)" "unprognostic (1.34e-3)" "unprognostic (4.62e-3)" "unprognostic (6.88e-2)" "unprognostic (1.53e-2)" "unprognostic (1.51e-2)" "unprognostic (4.77e-3)" "prognostic favourable (2.13e-4)" 7.7 7.0 29.6 4.7 22.8 3.7 2.2 14.3 32.0 3.3 3.4 5.3 1.8 4.4 4.5 1.8 3.7 3.1 4.0 8.2 28.2 11.2 4.7 2.1 4.2 4.6 11.5 9.4 4.3 8.1 4.7 5.2 3.7 9.0 4.6 2.0 2.4 6.9 4.8 22.9 5.6 5.0 4.0 5.3 6.7 6.2 6.6 7.1 2.3 3.3 2.6 2.4 3.8 5.4 0.8 0.0 0.0 0.2 0.0 0.9 0.0 6.2 7.5 2.3 5.5 2.2 1.3 6.5 4.4 2.2 2.0 2.1 1.7 1.8 5.7 4.6 1.5 2.0 0.9 2.2 0.3 10.9 7.1 1.5 3.2 1.7 4.2 1.2 3.7 1.2 5.4 2.2 1.5 1.9 5.4 9.8 0.6 3.7 4.7 2.3 2.8 4.9 5.9 2.5 3.4 1.8 4.0 7.8 11.3 5.1 1.8 10.3 2.5 2.3 3.1 5.3 5.1 7.8 8.4 13.0 7.5 2.5 6.2 2.4 7.7 0.0 0.1 0.0 0.4 0.2 0.0 0.8 0.2 0.9 0.0 0.1 0.1 0.5 0.0 0.0 0.1 0.0 0.0 0.0 29.6 22.8 14.3 28.7 28.2 11.2 11.5 9.4 9.0 7.1 MAP3K11 "MEKK11, MLK3, PTK1, SPRK" ENSG00000173327 "Mitogen-activated protein kinase kinase kinase 11" Q16584 11 65597755-65615382 "Enzymes, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "vagina: 75.8" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" CAB010165 Approved Supported "Centriolar satellite,Cytosol" "Centriolar satellite, Cytosol" "CAB010165: AB_631936" "unprognostic (8.36e-2)" "unprognostic (1.17e-2)" "unprognostic (1.06e-1)" "unprognostic (9.99e-2)" "unprognostic (3.40e-1)" "unprognostic (1.87e-1)" "unprognostic (7.56e-3)" "unprognostic (3.10e-2)" "unprognostic (4.50e-2)" "unprognostic (4.30e-1)" "unprognostic (4.69e-2)" "unprognostic (2.77e-2)" "unprognostic (3.13e-2)" "unprognostic (2.01e-2)" "unprognostic (7.62e-2)" "unprognostic (1.95e-1)" "unprognostic (8.27e-3)" 23.2 10.8 11.4 23.7 21.2 14.2 27.4 7.9 13.8 8.6 15.8 29.8 6.1 31.9 11.0 8.1 14.7 11.6 12.0 11.6 13.3 8.1 16.1 31.2 21.1 14.4 30.9 8.2 8.4 12.5 8.3 10.3 14.7 16.7 13.4 8.2 15.4 13.5 9.5 11.9 13.7 31.9 8.6 17.7 28.8 16.9 8.6 19.0 8.9 13.6 7.6 12.7 8.9 75.8 2.3 7.6 13.8 12.0 1.8 3.5 5.6 16.5 14.6 7.9 8.4 2.5 3.2 8.1 6.4 4.5 7.7 5.3 14.6 16.0 6.2 23.7 5.0 14.4 4.7 6.9 2.8 13.6 6.0 17.5 10.0 17.4 7.0 10.0 26.5 5.0 6.7 5.7 5.2 21.5 7.5 12.5 4.0 20.4 11.7 18.9 8.6 18.7 19.5 5.1 12.6 7.2 14.3 7.1 8.0 7.5 21.8 37.5 17.4 16.3 23.9 11.8 12.8 17.2 11.3 8.0 9.0 5.5 13.8 11.6 27.3 4.3 7.7 9.2 2.4 12.0 2.4 2.0 2.6 3.5 7.6 2.3 2.0 1.5 13.8 1.8 11.7 2.3 1.4 5.6 11.4 21.2 7.9 13.8 13.3 8.1 30.9 8.2 16.7 19.0 MAP3K12 "DLK, MEKK12, MUK, ZPK, ZPKP1" ENSG00000139625 "Mitogen-activated protein kinase kinase kinase 12" Q12852 12 53479669-53500063 "Enzymes, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 40.3" "Cell line enhanced" "Detected in many" "ASC diff: 28.4;HHSteC: 27.1;HSkMC: 27.0" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Group enriched" "Detected in many" 4 "granulocytes: 3.4;monocytes: 1.7;T-cells: 2.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA039936, HPA071996" Enhanced Approved "Nucleoplasm,Cell Junctions" "Nucleoplasm, Cell Junctions" "HPA039936: AB_10795239, HPA071996: " "unprognostic (4.01e-1)" "unprognostic (3.30e-1)" "unprognostic (8.89e-3)" "unprognostic (6.40e-3)" "unprognostic (1.10e-1)" "unprognostic (2.22e-1)" "unprognostic (6.97e-2)" "unprognostic (3.61e-2)" "unprognostic (2.39e-1)" "unprognostic (2.70e-1)" "prognostic favourable (1.51e-4)" "unprognostic (8.50e-3)" "prognostic unfavourable (5.43e-10)" "unprognostic (1.65e-2)" "unprognostic (2.44e-1)" "unprognostic (1.32e-1)" "unprognostic (1.18e-1)" 8.0 8.7 12.3 5.8 16.0 3.0 5.1 40.3 20.6 14.1 6.1 7.0 7.8 3.6 15.1 5.8 4.6 11.5 16.1 4.2 9.4 7.7 4.5 1.4 8.8 4.5 6.4 14.7 13.7 1.8 3.0 12.7 7.3 10.8 5.9 4.6 9.5 2.4 13.5 1.2 4.5 4.1 16.9 5.3 5.3 3.9 6.5 7.4 2.7 4.3 1.4 3.2 11.3 6.4 0.3 0.6 3.4 1.7 0.6 2.8 0.5 0.2 7.5 4.7 7.3 28.4 15.2 0.6 5.1 9.6 5.6 5.6 0.1 0.9 1.7 2.9 5.4 0.0 2.1 3.4 2.2 2.5 2.6 1.8 3.8 0.0 27.1 0.0 1.9 27.0 2.4 7.6 4.0 8.7 0.0 8.1 5.3 3.3 1.8 0.4 1.6 2.8 2.6 3.2 0.4 2.8 0.0 4.7 6.4 2.7 3.5 7.2 2.4 4.7 6.4 5.4 5.8 2.4 1.3 3.3 3.7 0.0 8.7 3.3 5.2 0.0 1.7 0.0 1.5 1.3 2.8 0.3 2.1 2.3 0.6 0.0 0.9 1.2 3.4 0.6 0.4 0.3 0.4 0.5 12.3 16.0 40.3 20.6 9.4 7.7 6.4 14.7 10.8 7.4 MAP3K13 "LZK, MEKK13" ENSG00000073803 "Mitogen-activated protein kinase kinase kinase 13" O43283 3 185282941-185489097 "Cancer-related genes, Enzymes, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA016497, HPA036691, HPA036692" Uncertain Approved "Nucleoplasm,Centriolar satellite,Cytosol" "Centriolar satellite" "Nucleoplasm, Cytosol" "HPA016497: AB_10670027, HPA036691: AB_10673661, HPA036692: AB_10670845" "unprognostic (8.95e-2)" "unprognostic (6.72e-3)" "unprognostic (9.46e-2)" "prognostic unfavourable (1.28e-5)" "unprognostic (5.16e-2)" "unprognostic (2.81e-1)" "unprognostic (2.61e-1)" "unprognostic (1.23e-2)" "unprognostic (9.04e-2)" "prognostic favourable (1.11e-4)" "prognostic unfavourable (7.27e-5)" "unprognostic (2.70e-3)" "unprognostic (1.54e-2)" "unprognostic (2.94e-2)" "unprognostic (2.82e-1)" "unprognostic (6.64e-2)" "unprognostic (9.31e-3)" 9.8 24.8 21.7 8.7 22.2 9.5 15.1 16.4 26.1 12.9 16.9 18.4 10.5 16.8 12.9 42.1 15.2 14.6 13.1 8.1 19.2 18.6 21.9 20.7 15.2 7.4 23.2 17.1 16.5 24.9 20.9 24.5 9.1 21.8 14.5 18.9 18.6 26.2 11.4 3.3 9.8 23.4 12.1 26.4 8.7 16.4 12.9 15.8 4.4 18.6 8.3 10.3 12.5 11.5 23.7 21.5 21.1 13.2 11.5 17.4 7.8 29.1 5.8 11.3 0.3 10.3 12.7 6.6 6.7 4.6 10.9 13.2 11.2 11.0 0.2 23.0 12.2 16.7 0.3 15.5 19.4 32.4 15.0 0.1 7.9 9.2 11.2 15.3 8.4 11.5 13.6 9.3 11.7 12.1 0.3 23.7 9.7 9.1 1.8 7.2 13.0 13.7 0.2 13.5 16.0 19.2 7.6 18.6 12.4 11.3 17.1 23.2 25.8 8.6 8.0 9.0 11.7 16.2 14.5 12.1 15.6 9.6 13.2 7.8 14.7 6.4 13.2 5.1 10.3 12.2 15.8 23.7 12.4 12.8 21.5 19.0 17.4 16.8 21.1 11.5 8.6 9.4 4.8 7.8 21.7 22.2 16.4 26.1 19.2 18.6 23.2 17.1 21.8 15.8 MAP3K14 "FTDCR1B, HS, HSNIK, NIK" ENSG00000006062 "Mitogen-activated protein kinase kinase kinase 14" Q99558 17 45263121-45317040 "Enzymes, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell line enhanced" "Detected in many" "A549: 22.0;HDLM-2: 22.6;U-251 MG: 22.1" "Low cancer specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "HPA027269, HPA027270" Approved Supported "Nucleoplasm,Nucleoli fibrillar center,Vesicles,Cytosol" "Vesicles, Cytosol" "Nucleoplasm, Nucleoli fibrillar center" "HPA027269: AB_10600302, HPA027270: AB_10600884" "unprognostic (1.05e-2)" "prognostic favourable (5.27e-5)" "unprognostic (2.71e-2)" "unprognostic (9.42e-2)" "unprognostic (5.31e-2)" "unprognostic (2.61e-3)" "unprognostic (2.70e-2)" "unprognostic (1.72e-1)" "unprognostic (3.40e-1)" "unprognostic (3.45e-1)" "unprognostic (1.07e-2)" "unprognostic (1.78e-1)" "prognostic unfavourable (2.78e-4)" "unprognostic (8.82e-2)" "unprognostic (3.49e-2)" "unprognostic (1.03e-2)" "unprognostic (2.28e-1)" 3.7 3.4 3.0 14.7 4.0 3.4 2.7 4.9 3.6 5.0 7.3 4.5 3.5 6.0 5.5 3.3 6.8 4.2 6.2 4.5 3.0 4.4 5.1 4.9 12.0 3.0 0.6 3.5 5.7 3.5 7.7 1.5 4.6 5.2 3.5 4.3 7.5 4.8 14.5 6.1 9.6 5.2 4.1 8.4 4.0 4.5 4.5 7.1 2.2 6.9 18.0 4.9 2.8 9.5 4.8 7.7 3.6 5.6 5.2 2.3 9.4 22.0 2.2 3.9 1.5 3.7 5.6 2.6 1.8 8.3 5.1 3.4 11.6 4.2 13.3 2.7 6.6 1.0 3.5 4.3 22.6 1.7 0.9 6.0 1.5 4.0 0.7 4.4 5.8 2.2 4.1 2.2 1.6 1.8 18.0 4.2 3.4 3.9 1.5 1.2 3.1 5.2 6.7 9.5 6.0 1.9 2.3 1.9 4.0 2.7 2.8 1.7 0.4 3.5 3.8 5.9 3.2 22.1 17.2 6.4 2.2 2.1 2.4 5.1 1.5 3.4 1.6 3.5 3.6 2.0 7.6 2.4 2.5 2.3 9.5 2.6 2.5 7.7 5.6 2.2 4.8 5.2 2.3 MAP3K15 "ASK3, bA723P2.3, FLJ16518" ENSG00000180815 "Mitogen-activated protein kinase kinase kinase 15" Q6ZN16 X 19360056-19515261 "Enzymes, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "adrenal gland: 17.3;brain: 13.2" "Cell line enhanced" "Detected in some" "A549: 3.4;HAP1: 8.6;HEK 293: 7.2;HEL: 2.9;REH: 4.4" "Low cancer specificity" "Detected in single" "Region enriched" "Detected in some" 6 "pons and medulla: 13.2" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in many" "Not detected" "Not detected" HPA004006 Approved Vesicles Vesicles "HPA004006: AB_1079358" "unprognostic (2.87e-1)" "unprognostic (7.09e-2)" "unprognostic (3.21e-2)" "unprognostic (6.56e-8)" "unprognostic (3.47e-2)" "unprognostic (1.42e-2)" "unprognostic (2.19e-3)" "unprognostic (2.35e-2)" "unprognostic (1.46e-1)" "unprognostic (4.87e-2)" "unprognostic (1.30e-2)" "unprognostic (8.95e-2)" "unprognostic (2.77e-3)" "unprognostic (4.00e-1)" "unprognostic (2.37e-1)" "unprognostic (3.98e-2)" "unprognostic (8.20e-2)" 0.1 17.3 0.5 0.4 0.3 0.5 0.1 2.3 0.1 0.1 0.1 5.0 0.0 0.0 0.1 0.0 0.1 0.1 0.0 0.1 0.4 0.5 3.6 0.1 0.5 0.0 0.1 0.0 1.3 4.1 0.4 5.7 0.0 13.2 0.1 0.0 4.1 0.1 0.0 0.1 0.1 0.1 0.0 0.1 2.6 0.1 2.1 0.0 0.0 0.1 0.0 0.0 0.1 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 3.4 0.1 0.3 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.4 0.0 0.0 8.6 0.0 0.0 1.4 7.2 2.9 0.0 0.8 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.2 0.0 2.2 2.2 0.9 4.4 0.0 0.0 0.5 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.5 0.3 2.3 0.1 0.4 0.5 0.1 0.0 13.2 0.0 MAP3K19 "FLJ23074, RCK, YSK4" ENSG00000176601 "Mitogen-activated protein kinase kinase kinase 19" Q56UN5 2 134964491-135047468 "Enzymes, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "brain: 18.3;fallopian tube: 23.9" "Group enriched" "Detected in some" 5 "RPMI-8226: 4.0;U-266/70: 2.3" "Cancer enhanced" "Detected in some" "endometrial cancer: 0.8" "Region enhanced" "Detected in many" "pons and medulla: 18.3" "Cell type enriched" "Detected in single" 6 "plasmacytoid DC: 1.5" "Lineage enriched" "Detected in single" 6 "dendritic cells: 1.5" "Low region specificity" "Detected in all" "Region enhanced" "Detected in many" "midbrain: 20.2" HPA011388 Uncertain Cytosol Cytosol "HPA011388: AB_1848822" "unprognostic (7.12e-3)" "unprognostic (6.55e-3)" "unprognostic (6.96e-2)" "unprognostic (3.90e-3)" "unprognostic (3.63e-1)" "unprognostic (2.21e-1)" "unprognostic (1.96e-1)" "unprognostic (9.38e-2)" "unprognostic (1.09e-1)" "unprognostic (4.33e-1)" "unprognostic (2.02e-2)" "unprognostic (1.32e-1)" "unprognostic (4.04e-6)" "unprognostic (1.50e-1)" "unprognostic (4.13e-2)" "unprognostic (1.54e-1)" "unprognostic (2.83e-4)" 0.1 0.2 1.7 0.2 6.2 0.1 0.1 0.0 0.5 1.1 0.2 7.3 0.0 0.2 1.0 6.7 0.2 23.9 0.1 0.1 2.9 3.8 0.2 0.2 5.6 0.2 0.5 1.5 7.3 0.1 0.1 1.0 0.1 18.3 0.3 0.2 0.0 0.2 0.2 0.3 0.2 0.2 0.1 0.5 0.2 0.2 7.6 3.1 0.0 0.1 0.0 0.1 0.1 0.0 0.0 1.5 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.3 0.6 0.0 4.0 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.3 0.6 0.0 0.2 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.5 0.2 0.0 1.7 6.2 0.0 0.5 2.9 3.8 0.5 1.5 18.3 3.1 MAP3K2 "MEKK2, MEKK2B" ENSG00000169967 "Mitogen-activated protein kinase kinase kinase 2" Q9Y2U5 2 127298730-127388465 "Enzymes, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Cell type enhanced" "Detected in all" "neutrophil: 13.6" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA021540 Approved Supported Nucleoplasm,Cytosol "Nucleoplasm, Cytosol" "HPA021540: " "unprognostic (5.81e-2)" "unprognostic (2.76e-1)" "unprognostic (1.58e-1)" "unprognostic (9.46e-2)" "unprognostic (1.02e-1)" "unprognostic (5.76e-2)" "unprognostic (7.19e-2)" "unprognostic (4.50e-1)" "unprognostic (1.27e-1)" "unprognostic (4.00e-1)" "unprognostic (1.25e-1)" "unprognostic (1.39e-1)" "unprognostic (4.97e-3)" "unprognostic (7.56e-2)" "unprognostic (8.93e-2)" "unprognostic (8.88e-2)" "unprognostic (2.11e-1)" 18.5 14.5 13.7 20.1 14.5 41.0 22.6 20.1 16.3 16.6 19.6 12.7 18.9 18.8 19.8 18.0 13.4 15.9 18.6 13.3 12.5 10.2 15.5 27.6 20.0 28.5 17.9 13.0 20.3 15.4 23.8 21.2 13.9 12.3 13.6 13.1 12.2 18.1 25.5 24.5 19.4 22.5 18.1 14.9 17.0 18.0 14.9 14.3 25.8 22.5 13.7 16.8 17.1 20.3 3.1 5.1 13.6 2.9 2.3 2.1 1.1 16.3 7.0 5.6 5.6 7.8 10.4 9.3 10.2 11.1 10.1 8.2 8.3 7.3 10.8 17.6 14.5 13.9 8.9 6.8 11.3 27.0 6.9 10.0 12.6 7.3 9.1 10.0 21.7 9.3 7.6 12.2 15.0 4.6 4.7 21.6 9.9 5.9 11.7 7.1 5.7 9.1 7.7 10.5 8.0 4.1 15.3 11.1 5.9 14.8 9.1 9.2 5.9 7.7 10.6 19.8 18.6 9.1 13.8 22.4 16.1 11.1 9.5 6.6 8.5 4.0 2.9 2.0 1.7 1.8 2.1 3.1 1.6 1.7 2.4 2.6 1.9 2.0 13.6 2.3 2.2 5.1 1.4 1.1 13.7 14.5 20.1 16.3 12.5 10.2 17.9 13.0 12.3 14.3 MAP3K20 "MLK7, MLTK, MLTKalpha, MLTKbeta, MRK, ZAK" ENSG00000091436 "Mitogen-activated protein kinase kinase kinase 20" Q9NYL2 2 173075435-173268010 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" "Cell cycle" "Kinase, Serine/threonine-protein kinase, Transferase" "Disease mutation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "skeletal muscle: 96.1" "Cell line enhanced" "Detected in many" "U-138 MG: 47.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Cell type enhanced" "Detected in many" "myeloid DC: 13.7" "Group enriched" "Detected in many" 5 "dendritic cells: 13.7;monocytes: 8.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA017205 Approved Supported Cytosol Cytosol "HPA017205: AB_1858933" "unprognostic (2.90e-2)" "unprognostic (9.99e-3)" "unprognostic (4.63e-3)" "unprognostic (1.98e-1)" "unprognostic (7.63e-2)" "unprognostic (5.02e-2)" "unprognostic (2.34e-2)" "unprognostic (3.89e-3)" "unprognostic (2.83e-2)" "unprognostic (9.27e-2)" "unprognostic (4.54e-2)" "unprognostic (1.74e-1)" "prognostic unfavourable (3.41e-6)" "unprognostic (2.34e-1)" "unprognostic (1.86e-1)" "unprognostic (2.23e-1)" "unprognostic (1.19e-2)" 21.7 5.0 2.9 7.4 3.3 0.8 9.2 2.8 3.1 25.7 24.8 2.1 10.7 3.1 30.2 15.4 26.2 13.1 14.9 52.5 3.5 3.0 2.4 8.5 7.5 2.5 4.5 3.0 21.7 4.4 22.6 3.1 6.9 4.2 25.6 5.4 11.5 6.7 15.8 96.1 5.8 8.0 68.4 4.7 3.7 15.8 6.6 3.5 2.8 6.7 38.0 4.9 46.7 24.0 2.1 13.7 2.3 8.0 0.4 1.6 2.7 8.7 7.3 5.8 7.6 16.9 25.2 3.6 31.6 24.7 14.8 15.9 5.0 5.8 6.7 8.3 31.6 5.9 8.6 16.7 33.3 13.1 5.8 11.0 8.3 1.0 6.7 9.8 11.6 20.2 7.2 27.8 43.9 9.7 4.9 1.3 9.7 3.7 6.1 4.9 3.2 4.2 9.1 11.9 0.0 3.6 5.0 3.4 3.3 12.2 3.0 5.1 3.4 5.3 9.7 47.2 19.4 14.0 7.1 0.0 0.0 1.4 33.9 2.7 4.9 0.1 8.0 0.0 0.9 7.5 0.9 1.5 0.8 1.6 13.7 2.1 0.0 0.8 2.3 0.4 6.6 0.3 0.7 2.7 2.9 3.3 2.8 3.1 3.5 3.0 4.5 3.0 4.2 3.5 MAP3K21 "KIAA1804, MLK4" ENSG00000143674 "Mitogen-activated protein kinase kinase kinase 21" Q5TCX8 1 233327768-233385148 "Enzymes, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "pancreas: 28.9" "Cell line enhanced" "Detected in many" "HEK 293: 18.0" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Cell type enriched" "Detected in single" 6 "NK-cell: 5.0" "Lineage enriched" "Detected in single" 6 "NK-cells: 5.0" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA007636 Uncertain Approved "Plasma membrane,Cytosol" "Plasma membrane, Cytosol" "HPA007636: AB_1079392" "unprognostic (3.29e-2)" "unprognostic (5.10e-2)" "unprognostic (2.00e-1)" "unprognostic (2.42e-3)" "unprognostic (4.30e-2)" "unprognostic (1.23e-1)" "unprognostic (1.82e-2)" "unprognostic (1.84e-1)" "unprognostic (1.51e-1)" "unprognostic (1.25e-1)" "unprognostic (2.09e-1)" "unprognostic (8.21e-2)" "unprognostic (3.76e-2)" "unprognostic (2.23e-1)" "unprognostic (1.71e-1)" "unprognostic (9.22e-2)" "unprognostic (4.84e-2)" 0.6 3.2 2.0 3.4 2.2 1.3 2.2 10.0 3.3 1.5 11.4 0.6 9.1 9.9 0.8 5.2 2.4 3.9 3.9 0.7 1.3 2.1 12.5 13.3 5.6 0.5 0.9 1.7 0.8 28.9 4.4 2.6 1.0 1.2 1.3 6.0 1.0 3.7 2.5 0.4 2.7 17.2 0.3 0.9 0.7 10.1 12.4 0.6 0.5 2.4 0.8 1.3 1.1 1.6 0.5 0.8 0.1 0.3 5.0 0.2 0.1 7.3 12.5 0.2 0.0 0.0 0.0 6.3 0.2 0.0 0.3 0.5 6.9 6.4 0.7 5.2 0.1 3.9 9.4 3.8 0.8 13.6 18.0 0.1 7.0 0.0 0.4 11.9 2.9 0.1 5.1 0.2 7.3 0.4 0.1 2.4 0.0 1.6 3.8 4.3 8.9 5.5 0.0 0.0 13.1 8.6 3.1 9.2 2.5 4.3 0.2 0.0 3.7 3.8 0.0 0.0 1.2 0.0 7.3 2.2 2.8 0.0 1.2 3.3 0.3 0.0 0.3 0.0 0.0 0.1 0.0 0.3 0.2 0.1 0.8 0.5 0.0 0.0 0.1 5.0 0.0 0.2 0.2 0.1 2.0 2.2 10.0 3.3 1.3 2.1 0.9 1.7 1.2 0.6 MAP3K3 "MAPKKK3, MEKK3" ENSG00000198909 "Mitogen-activated protein kinase kinase kinase 3" Q99759 17 63622415-63696303 "Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB007764, HPA035410, HPA035411" Uncertain Approved Nucleoplasm Nucleoplasm "CAB007764: AB_562314, HPA035410: , HPA035411: " "unprognostic (9.65e-3)" "unprognostic (1.33e-1)" "unprognostic (5.14e-2)" "prognostic unfavourable (1.13e-4)" "unprognostic (1.16e-1)" "unprognostic (4.12e-2)" "unprognostic (1.03e-2)" "unprognostic (1.33e-1)" "unprognostic (1.36e-1)" "unprognostic (9.37e-2)" "unprognostic (1.46e-3)" "unprognostic (5.51e-2)" "unprognostic (2.35e-1)" "unprognostic (2.79e-2)" "unprognostic (4.68e-2)" "unprognostic (1.09e-1)" "unprognostic (3.08e-2)" 23.9 11.8 10.5 20.5 15.0 24.8 19.1 26.8 14.9 22.2 21.8 15.0 14.0 8.0 24.5 13.2 16.6 18.3 20.6 37.4 11.3 8.4 17.1 12.4 23.1 21.4 14.4 9.6 21.6 11.4 16.9 12.3 21.0 11.9 18.4 8.3 21.7 12.8 18.5 19.6 15.4 14.7 20.4 13.2 30.4 16.4 26.5 12.3 12.9 15.5 12.8 15.4 19.0 26.8 1.9 3.5 18.3 8.5 1.1 2.6 2.3 10.1 7.6 9.7 9.4 18.6 15.0 4.4 10.0 11.0 12.5 10.1 3.5 2.1 10.9 7.1 19.6 3.8 6.3 7.1 7.9 9.5 13.9 8.9 10.3 4.9 9.7 6.8 9.5 10.7 4.9 15.5 8.2 30.3 5.4 14.5 9.9 7.1 12.2 7.1 6.0 8.1 6.5 24.8 7.1 4.5 4.6 5.0 11.9 6.8 8.2 8.3 8.2 6.8 27.2 32.0 8.5 17.3 12.1 14.4 14.6 4.0 6.9 5.5 8.3 8.8 8.5 10.4 2.2 8.3 2.3 1.5 2.6 2.1 3.5 1.9 2.5 2.5 18.3 1.1 8.2 1.3 1.9 2.3 10.5 15.0 26.8 14.9 11.3 8.4 14.4 9.6 11.9 12.3 MAP3K4 "KIAA0213, MAPKKK4, MEKK4, MTK1" ENSG00000085511 "Mitogen-activated protein kinase kinase kinase 4" Q9Y6R4 6 160991727-161117385 "Cancer-related genes, Enzymes, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA007625 Uncertain Approved Cytosol Cytosol "HPA007625: AB_1853770" "unprognostic (3.05e-3)" "unprognostic (2.19e-2)" "unprognostic (1.36e-1)" "unprognostic (1.44e-1)" "unprognostic (2.06e-1)" "unprognostic (7.65e-2)" "unprognostic (1.35e-3)" "unprognostic (6.38e-2)" "unprognostic (2.09e-1)" "unprognostic (3.81e-3)" "unprognostic (2.09e-2)" "unprognostic (2.61e-1)" "unprognostic (1.16e-2)" "unprognostic (5.86e-2)" "unprognostic (3.45e-1)" "unprognostic (1.93e-1)" "unprognostic (6.84e-2)" 12.0 8.0 13.1 17.7 12.6 9.1 14.6 23.1 14.0 16.4 13.9 9.3 12.2 9.5 22.2 11.9 21.4 14.1 11.4 12.4 11.9 7.8 9.4 8.2 15.9 14.4 12.8 8.9 17.4 12.1 15.8 16.2 12.4 9.2 14.2 9.8 9.4 15.0 15.4 24.4 15.1 13.3 13.9 7.7 10.6 11.1 13.5 12.4 16.2 10.6 13.0 16.8 15.8 23.9 8.8 5.4 17.5 3.8 3.5 8.9 2.2 4.6 5.3 10.1 8.6 6.3 7.4 6.5 5.3 4.7 6.1 6.5 7.5 3.4 9.6 3.8 13.5 11.7 10.3 10.6 7.5 7.0 8.4 12.5 4.9 7.4 4.8 13.0 6.1 4.6 12.3 6.4 5.8 7.9 31.6 11.1 6.5 4.8 8.7 6.6 6.1 8.2 9.6 9.3 7.6 5.6 3.4 5.8 5.2 9.9 10.6 0.9 4.3 15.9 7.4 7.5 9.6 6.9 25.0 6.5 5.2 8.8 8.8 13.4 7.8 17.5 3.8 2.3 5.0 3.0 8.9 6.2 7.1 4.5 4.3 8.8 5.0 4.9 0.2 3.5 1.7 5.4 4.8 2.2 13.1 12.6 23.1 14.0 11.9 7.8 12.8 8.9 9.2 12.4 MAP3K5 "ASK1, MAPKKK5, MEKK5" ENSG00000197442 "Mitogen-activated protein kinase kinase kinase 5" Q99683 6 136557047-136792518 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Apoptosis, Host-virus interaction, Immunity, Innate immunity, Stress response" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "adrenal gland: 55.6" "Cell line enhanced" "Detected in many" "BJ hTERT+: 22.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB007824, HPA063245" Supported Supported Cytosol Cytosol "CAB007824: AB_598175, HPA063245: " "unprognostic (1.37e-1)" "unprognostic (3.21e-2)" "unprognostic (2.85e-2)" "unprognostic (1.38e-1)" "unprognostic (3.19e-1)" "prognostic favourable (6.08e-4)" "unprognostic (8.76e-2)" "unprognostic (1.41e-2)" "unprognostic (2.84e-1)" "unprognostic (1.90e-2)" "prognostic unfavourable (5.91e-4)" "unprognostic (3.97e-1)" "unprognostic (3.75e-2)" "unprognostic (1.37e-1)" "unprognostic (2.72e-1)" "unprognostic (2.72e-2)" "unprognostic (6.59e-3)" 7.7 55.6 13.0 7.5 17.6 7.6 5.5 12.9 12.7 4.0 5.4 6.9 3.6 4.6 7.2 5.1 6.4 6.1 4.9 7.3 11.8 6.8 6.8 5.5 7.7 8.8 8.2 6.4 32.4 28.2 1.5 9.9 3.4 7.9 11.6 6.2 5.8 4.2 4.9 3.7 5.0 4.6 4.3 7.5 9.8 8.7 7.3 8.6 2.0 10.0 3.4 9.0 10.8 18.9 2.5 2.5 8.5 3.0 4.1 7.0 1.4 2.8 1.7 0.0 0.0 4.1 11.1 1.0 4.1 22.3 2.1 2.0 0.1 2.9 1.7 6.1 5.7 4.0 7.1 2.1 5.6 2.3 5.6 14.7 3.9 0.0 19.8 6.8 0.0 14.6 2.8 3.3 9.6 7.1 3.6 16.5 15.0 5.5 0.1 5.8 0.7 2.4 3.8 4.7 6.7 8.6 18.3 5.2 3.4 3.4 3.3 0.9 0.7 6.1 6.2 3.6 1.1 0.2 3.8 13.5 8.9 0.0 2.8 9.6 3.1 5.7 3.0 3.3 2.7 2.3 4.9 2.0 4.3 3.7 2.5 2.5 0.4 1.4 8.5 4.1 2.1 2.4 7.0 1.4 13.0 17.6 12.9 9.4 11.8 6.8 8.2 6.4 7.9 8.6 MAP3K6 "ASK2, MAPKKK6, MEKK6" ENSG00000142733 "Mitogen-activated protein kinase kinase kinase 6" O95382 1 27355184-27366892 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skin 1: 63.9" "Low cell line specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in many" "Low region specificity" "Detected in some" HPA051192 Approved Approved "Nucleoplasm,Plasma membrane,Actin filaments,Cytosol" Nucleoplasm "Plasma membrane, Actin filaments, Cytosol" "HPA051192: " "unprognostic (1.19e-2)" "unprognostic (2.77e-3)" "unprognostic (2.62e-2)" "unprognostic (1.97e-2)" "prognostic unfavourable (2.13e-4)" "prognostic favourable (7.26e-4)" "prognostic unfavourable (8.76e-4)" "unprognostic (9.10e-2)" "unprognostic (2.79e-1)" "unprognostic (6.91e-2)" "unprognostic (6.56e-2)" "unprognostic (1.25e-1)" "unprognostic (4.65e-3)" "unprognostic (4.95e-2)" "unprognostic (2.79e-1)" "unprognostic (7.07e-3)" "unprognostic (1.50e-1)" 37.5 6.3 7.4 6.9 8.6 1.3 22.1 12.6 8.3 19.9 9.0 2.7 8.9 3.3 13.1 10.3 25.7 12.8 12.4 14.9 6.2 2.6 13.6 5.0 21.7 5.5 11.4 1.9 11.7 8.3 8.2 15.8 7.3 9.8 13.9 5.9 15.7 11.5 9.7 6.3 63.9 6.2 16.0 11.7 8.7 9.0 6.7 7.0 0.6 12.0 16.1 14.3 14.3 18.3 2.7 3.3 5.1 6.9 1.1 7.6 2.4 7.4 6.9 6.2 6.9 8.7 15.3 1.6 9.3 5.4 7.0 5.3 2.0 10.0 0.1 8.3 14.1 11.8 2.1 6.5 3.5 6.2 5.1 0.5 16.0 3.1 2.7 0.5 0.6 12.2 15.9 7.3 2.6 4.7 2.3 4.1 11.1 18.4 0.3 8.4 1.9 5.7 2.7 4.1 1.7 10.5 7.8 2.3 3.4 9.8 8.6 7.3 4.6 6.4 9.8 17.6 7.4 19.7 4.8 3.3 4.1 0.1 15.6 6.1 5.1 1.8 1.5 5.1 5.3 3.3 7.6 2.7 5.5 5.9 3.3 2.3 4.4 3.6 2.4 1.1 6.9 0.0 5.6 2.4 7.4 8.6 12.6 8.3 6.2 2.6 11.4 1.9 9.8 7.0 MAP3K7 "MEKK7, TAK1" ENSG00000135341 "Mitogen-activated protein kinase kinase kinase 7" O43318 6 90513573-90587045 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" "Apoptosis, Host-virus interaction, Stress response, Transcription, Transcription regulation" "Kinase, Serine/threonine-protein kinase, Transferase" "Disease mutation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA007633, HPA075335" Approved Supported "Nuclear speckles,Plasma membrane,Cytosol" Cytosol "Nuclear speckles, Plasma membrane" "HPA007633: AB_1079359, HPA075335: " "unprognostic (1.48e-1)" "unprognostic (3.45e-2)" "unprognostic (1.35e-1)" "unprognostic (6.48e-2)" "unprognostic (1.44e-1)" "unprognostic (1.84e-1)" "prognostic unfavourable (3.51e-4)" "unprognostic (9.77e-2)" "unprognostic (6.51e-2)" "unprognostic (1.98e-2)" "unprognostic (1.44e-1)" "unprognostic (2.79e-1)" "unprognostic (2.56e-3)" "unprognostic (4.76e-2)" "unprognostic (1.95e-1)" "unprognostic (2.08e-1)" "unprognostic (1.17e-1)" 15.5 17.6 19.6 17.3 26.3 10.3 21.6 27.5 27.3 21.1 16.4 15.7 15.8 12.5 23.1 23.6 15.2 15.5 17.6 22.2 20.5 17.5 15.9 15.5 20.0 22.2 22.9 16.4 25.0 13.5 25.8 25.6 23.6 20.7 21.2 15.3 12.4 17.0 23.3 24.3 18.7 14.7 19.4 23.0 23.3 14.7 13.8 21.7 28.2 20.3 10.8 21.9 17.2 18.9 14.2 15.9 19.4 17.7 18.2 22.1 13.6 7.7 6.9 20.1 17.2 14.7 19.7 14.2 15.6 18.1 14.1 17.8 8.8 7.5 17.3 10.0 16.9 8.3 12.6 12.2 24.0 8.8 13.4 15.4 9.5 11.7 15.4 17.1 11.9 16.2 14.9 13.7 16.9 13.2 30.8 14.2 20.1 9.5 7.9 14.5 16.5 8.7 13.7 36.1 8.4 11.8 8.7 10.2 14.5 10.9 7.6 11.8 7.5 30.5 12.6 11.5 7.3 10.5 14.5 12.7 11.3 7.5 17.6 18.8 16.8 15.5 12.7 19.4 15.1 17.4 16.8 14.2 14.5 14.4 15.9 10.5 16.5 16.0 12.5 18.2 17.7 9.8 22.1 13.6 19.6 26.3 27.5 27.3 20.5 17.5 22.9 16.4 20.7 21.7 MAP3K8 "c-COT, COT, EST, ESTF, MEKK8, Tpl-2" ENSG00000107968 "Mitogen-activated protein kinase kinase kinase 8" P41279 10 30433937-30461833 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Cell cycle, Immunity" "Kinase, Serine/threonine-protein kinase, Transferase" Proto-oncogene "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 104.6" "Cell line enhanced" "Detected in many" "HMC-1: 24.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "CAB005120, HPA017962" Supported Supported Cytosol Cytosol "CAB005120: AB_2140669, HPA017962: AB_1853776" "unprognostic (1.91e-2)" "unprognostic (2.94e-1)" "unprognostic (3.07e-1)" "unprognostic (9.29e-2)" "unprognostic (6.73e-2)" "unprognostic (1.00e-2)" "unprognostic (1.44e-1)" "unprognostic (3.36e-2)" "unprognostic (1.41e-2)" "unprognostic (8.04e-3)" "unprognostic (8.23e-2)" "unprognostic (2.96e-1)" "prognostic unfavourable (8.76e-7)" "unprognostic (1.88e-1)" "unprognostic (1.49e-1)" "unprognostic (1.63e-2)" "unprognostic (5.98e-3)" 28.0 7.6 3.6 15.6 4.1 104.6 26.1 1.5 2.6 8.2 8.4 2.7 11.3 3.4 11.5 16.5 13.8 19.5 15.3 20.1 4.3 2.9 6.3 7.6 29.0 33.7 4.3 2.0 9.8 3.6 2.8 4.1 27.5 8.3 7.9 6.8 9.4 6.1 18.4 8.6 15.3 9.6 23.4 9.7 25.6 10.7 6.7 3.6 2.4 7.0 13.2 17.2 13.2 15.6 19.6 13.8 23.7 16.8 12.4 7.8 4.0 7.9 7.1 1.9 4.1 10.3 8.7 9.1 2.0 11.9 4.4 5.3 4.9 18.5 5.2 5.1 4.2 14.9 4.5 1.9 1.6 12.0 2.3 9.7 12.1 15.7 8.7 3.0 24.0 10.8 1.1 4.4 0.8 1.9 4.3 7.8 0.7 4.5 0.1 11.6 0.7 2.5 0.6 1.6 3.0 4.4 16.1 0.2 0.8 7.1 6.1 0.9 2.0 6.4 0.1 2.7 2.3 9.7 0.3 11.9 11.1 1.5 3.9 13.2 0.1 17.9 7.0 23.7 7.8 12.0 4.3 9.6 1.7 4.9 6.6 19.6 0.1 3.0 16.7 12.4 16.8 13.8 0.4 4.0 3.6 4.1 1.5 2.6 4.3 2.9 4.3 2.0 8.3 3.6 MAP3K9 "MEKK9, MLK1, PRKE1" ENSG00000006432 "Mitogen-activated protein kinase kinase kinase 9" P80192 14 70722526-70809534 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" "Apoptosis, Stress response, Transcription, Transcription regulation" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 20.1" "Cell line enhanced" "Detected in many" "A-431: 17.7" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA000942 Approved Approved Nucleoplasm,Nucleoli "Intracellular and membrane" "Nucleoplasm, Nucleoli" "HPA000942: AB_1079360" "unprognostic (1.20e-1)" "unprognostic (3.75e-1)" "unprognostic (4.01e-2)" "unprognostic (1.43e-2)" "unprognostic (3.16e-3)" "unprognostic (2.45e-2)" "unprognostic (3.75e-5)" "unprognostic (2.58e-1)" "unprognostic (4.20e-2)" "unprognostic (4.38e-2)" "unprognostic (1.53e-2)" "unprognostic (2.48e-2)" "unprognostic (4.23e-6)" "unprognostic (5.71e-3)" "unprognostic (6.86e-3)" "unprognostic (1.79e-1)" "unprognostic (2.35e-1)" 0.5 2.2 5.8 2.0 9.2 1.4 2.8 20.1 16.5 2.4 3.1 1.8 0.4 3.0 1.1 3.4 10.1 2.2 1.5 1.2 5.7 7.1 3.1 2.4 3.9 2.6 5.9 5.9 1.4 4.3 6.8 4.7 2.8 12.8 2.0 3.1 3.1 3.2 1.3 1.9 7.8 2.9 0.7 1.6 1.9 3.4 10.1 1.8 0.6 5.3 3.2 6.8 2.0 3.9 2.3 0.5 1.3 0.2 1.1 1.4 0.3 17.7 8.2 1.6 2.0 0.0 0.0 5.5 0.3 0.2 1.7 1.5 5.9 6.8 3.6 2.4 0.1 8.4 5.2 10.0 1.8 2.4 1.5 0.2 2.9 3.9 0.2 0.4 0.8 0.1 5.5 1.2 10.4 0.0 1.3 0.8 0.4 7.1 2.8 0.4 3.5 3.8 1.0 3.1 0.7 3.9 8.2 11.3 2.4 5.1 6.1 1.0 5.5 0.6 0.0 0.0 7.2 0.0 2.8 1.9 4.3 1.9 2.7 0.3 1.0 0.5 0.2 0.8 0.6 0.1 0.1 1.0 0.6 1.0 0.0 2.3 1.0 0.7 1.3 1.1 0.2 0.5 1.4 0.3 5.8 9.2 20.1 16.5 5.7 7.1 5.9 5.9 12.8 1.8 MAP4K1 HPK1 ENSG00000104814 "Mitogen-activated protein kinase kinase kinase kinase 1" Q92918 19 38587641-38618882 "Enzymes, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "blood: 16.2;intestine: 16.9;lymphoid tissue: 39.2" "Cell line enhanced" "Detected in some" "Daudi: 20.5;HDLM-2: 20.3;Karpas-707: 21.1;REH: 11.2;RPMI-8226: 12.7;U-266/70: 16.6;U-266/84: 16.3;U-698: 25.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "HPA007419, CAB007754" Enhanced Uncertain "Nucleoplasm,Plasma membrane" "Nucleoplasm, Plasma membrane" "CAB007754: AB_562299, HPA007419: AB_1853778" "unprognostic (1.99e-3)" "prognostic favourable (6.17e-5)" "unprognostic (9.50e-3)" "unprognostic (3.27e-1)" "unprognostic (6.03e-2)" "prognostic favourable (3.26e-4)" "unprognostic (4.88e-3)" "unprognostic (5.32e-3)" "unprognostic (2.79e-1)" "unprognostic (2.51e-1)" "unprognostic (3.92e-2)" "unprognostic (2.55e-1)" "prognostic unfavourable (7.99e-10)" "unprognostic (1.72e-1)" "unprognostic (1.83e-1)" "unprognostic (3.18e-2)" "unprognostic (1.50e-2)" 1.6 0.9 1.2 31.4 2.3 6.3 1.1 1.0 1.2 1.0 3.1 1.7 0.1 2.1 0.9 1.4 2.6 1.2 2.9 0.9 1.1 1.4 2.2 1.6 3.9 23.0 2.3 0.7 0.8 1.2 0.2 1.2 1.4 2.1 1.6 1.9 2.0 4.4 0.8 0.5 1.2 16.9 0.7 3.4 34.4 2.3 0.9 1.3 19.1 1.9 1.4 39.2 3.1 1.3 16.2 15.9 1.3 6.2 3.7 14.6 7.3 0.0 0.1 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 20.5 0.3 0.0 0.0 0.0 0.0 0.0 20.3 0.1 4.3 0.0 0.0 0.0 1.4 0.2 0.0 0.0 0.0 0.0 0.0 0.1 21.1 0.0 0.1 4.9 5.1 0.6 0.0 11.2 0.0 12.7 0.0 0.0 0.2 0.0 0.0 0.1 0.0 0.1 4.6 0.0 0.0 0.1 0.0 0.0 16.6 16.3 25.8 0.0 5.8 0.0 1.3 3.2 1.2 13.4 6.2 12.4 16.2 11.2 14.0 15.9 10.7 6.2 8.7 0.3 3.7 3.4 14.0 14.6 7.3 1.2 2.3 1.0 1.2 1.1 1.4 2.3 0.7 2.1 1.3 MAP4K2 "BL44, GCK, RAB8IP" ENSG00000168067 "Mitogen-activated protein kinase kinase kinase kinase 2" Q12851 11 64784914-64803241 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Immunity, Innate immunity, Stress response" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA007330 Enhanced Approved Vesicles Vesicles "HPA007330: AB_1079361" "unprognostic (1.66e-1)" "unprognostic (2.83e-1)" "unprognostic (3.07e-3)" "unprognostic (4.37e-3)" "unprognostic (2.67e-1)" "unprognostic (9.23e-2)" "prognostic unfavourable (3.10e-5)" "unprognostic (4.51e-2)" "unprognostic (3.65e-1)" "unprognostic (5.28e-2)" "unprognostic (1.24e-2)" "unprognostic (1.41e-1)" "unprognostic (2.47e-2)" "unprognostic (2.97e-1)" "unprognostic (1.57e-2)" "unprognostic (1.82e-1)" "unprognostic (1.95e-2)" 6.9 6.2 9.4 15.2 10.0 19.1 5.8 12.1 15.6 5.2 5.8 10.1 6.9 4.9 6.2 4.0 4.3 4.4 6.3 5.5 9.4 9.2 6.2 3.1 12.0 22.3 8.3 7.3 4.2 7.2 5.2 8.0 12.3 12.5 6.1 4.7 6.7 9.0 8.9 3.4 5.0 9.9 5.6 6.7 22.6 7.1 5.5 6.6 11.5 8.7 3.9 18.8 6.1 5.1 10.8 5.0 8.2 14.8 2.3 9.6 7.1 6.1 5.5 3.6 6.6 3.3 2.0 8.6 4.6 4.3 5.6 3.9 2.4 2.9 10.7 8.6 5.2 1.8 4.4 4.5 3.3 13.9 2.1 18.8 7.7 5.1 4.0 9.9 7.1 2.0 2.3 4.3 2.8 13.6 1.6 1.0 1.7 7.6 5.8 9.9 2.4 7.5 12.2 0.4 12.3 3.1 3.1 4.4 6.3 4.0 5.2 4.1 10.5 15.2 10.5 4.7 10.5 4.3 1.9 1.2 2.4 11.6 4.1 15.0 3.4 2.2 4.2 5.6 5.2 12.2 5.3 10.8 7.0 4.7 4.4 7.6 8.6 6.3 8.2 2.3 14.8 5.0 9.6 7.1 9.4 10.0 12.1 15.6 9.4 9.2 8.3 7.3 12.5 6.6 MAP4K3 "GLK, MAPKKKK3, RAB8IPL1" ENSG00000011566 "Mitogen-activated protein kinase kinase kinase kinase 3" Q8IVH8 2 39249266-39437312 "Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell line enhanced" "Detected in many" "AF22: 40.8;RT4: 37.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA030380 Approved Approved "Nucleoplasm,Centriolar satellite" "Centriolar satellite" Nucleoplasm "HPA030380: AB_10601132" "unprognostic (4.82e-2)" "unprognostic (7.22e-2)" "unprognostic (5.87e-3)" "unprognostic (7.34e-3)" "unprognostic (6.77e-2)" "unprognostic (2.57e-1)" "unprognostic (1.05e-2)" "unprognostic (6.73e-2)" "unprognostic (1.66e-1)" "unprognostic (6.73e-2)" "unprognostic (4.33e-3)" "unprognostic (4.26e-2)" "unprognostic (2.12e-1)" "unprognostic (3.08e-2)" "unprognostic (3.30e-1)" "unprognostic (2.43e-1)" "unprognostic (5.08e-2)" 19.7 18.9 17.6 15.4 17.6 9.6 17.8 37.1 19.6 19.2 16.9 14.6 9.8 13.7 23.5 14.8 11.1 15.3 18.7 19.5 15.4 12.5 26.2 15.4 15.6 5.8 15.4 13.4 24.6 14.0 25.7 24.6 30.8 14.4 18.6 14.1 17.9 13.3 15.7 33.0 17.8 17.2 18.6 15.3 11.5 26.1 21.0 16.5 9.4 25.9 11.3 7.5 18.8 32.6 0.7 0.5 2.5 1.9 1.0 1.3 0.4 9.7 6.1 40.8 6.4 6.6 13.4 11.2 8.7 11.1 8.6 7.4 5.1 4.9 2.1 9.8 5.9 5.3 15.3 7.7 13.2 2.4 6.3 3.5 4.3 11.9 17.3 1.5 5.8 11.9 7.7 11.2 12.1 7.4 4.5 4.0 11.5 5.3 3.4 2.3 12.3 9.3 3.7 13.3 1.6 11.4 37.8 7.3 8.3 5.1 8.2 22.6 5.5 2.2 6.0 6.7 8.0 6.0 4.7 6.1 3.4 0.7 8.3 2.5 7.8 2.5 0.7 0.0 1.2 1.1 0.1 0.1 1.2 0.9 0.1 0.7 1.1 1.3 0.0 1.0 1.9 0.5 0.6 0.4 17.6 17.6 37.1 19.6 15.4 12.5 15.4 13.4 14.4 16.5 MAP4K4 "FLH21957, HGK, NIK" ENSG00000071054 "Mitogen-activated protein kinase kinase kinase kinase 4" O95819 2 101696850-101894689 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 81.2" "Low cell line specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA008476 Uncertain "HPA008476: AB_1079362" "unprognostic (6.40e-2)" "unprognostic (1.09e-2)" "unprognostic (4.01e-1)" "unprognostic (1.89e-1)" "unprognostic (1.88e-1)" "unprognostic (1.87e-2)" "unprognostic (2.83e-2)" "prognostic unfavourable (1.57e-4)" "unprognostic (4.29e-2)" "unprognostic (9.79e-2)" "unprognostic (2.22e-3)" "unprognostic (8.65e-2)" "prognostic unfavourable (3.62e-6)" "unprognostic (6.67e-3)" "unprognostic (8.98e-2)" "unprognostic (3.15e-1)" "unprognostic (7.14e-3)" 27.0 5.0 68.3 21.1 56.3 32.1 35.2 14.5 50.4 13.2 7.8 47.5 2.1 5.4 14.6 6.7 18.5 8.6 18.0 22.2 70.5 40.5 6.3 16.8 13.2 25.8 65.3 21.5 12.6 8.3 9.5 4.3 25.1 40.2 7.6 9.6 6.1 7.7 5.7 16.1 8.7 6.5 14.8 81.2 11.7 11.0 20.3 49.1 13.2 8.3 6.6 29.6 13.5 16.3 4.6 6.3 14.4 3.4 1.1 3.7 1.5 18.8 14.3 30.7 14.6 29.1 52.3 38.6 24.0 19.8 21.5 17.8 23.7 25.1 27.5 20.9 35.9 7.8 9.7 21.1 21.5 36.8 6.6 20.6 10.8 61.8 24.6 9.8 0.9 46.9 9.7 53.0 23.7 55.8 13.3 0.0 56.4 10.3 22.7 6.1 15.6 22.8 27.5 21.0 0.1 14.3 6.6 12.0 20.0 16.5 0.0 17.9 3.9 17.8 70.1 42.7 18.3 12.3 28.5 0.0 0.0 16.7 27.5 12.5 31.2 6.9 3.3 0.0 2.4 3.4 1.8 3.5 3.3 1.7 1.1 4.6 2.5 2.7 14.4 1.1 3.0 6.3 3.7 1.5 68.3 56.3 14.5 38.9 70.5 40.5 65.3 21.5 40.2 49.1 MINK1 "B55, MAP4K6, MINK, YSK2, ZC3" ENSG00000141503 "Misshapen like kinase 1" Q8N4C8 17 4833388-4898061 "Enzymes, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA056296 Approved "HPA056296: " "unprognostic (2.80e-1)" "unprognostic (3.83e-2)" "unprognostic (1.85e-1)" "unprognostic (6.62e-2)" "unprognostic (2.88e-1)" "unprognostic (3.26e-3)" "prognostic unfavourable (3.00e-4)" "unprognostic (4.64e-3)" "unprognostic (3.21e-1)" "unprognostic (2.78e-2)" "prognostic favourable (2.77e-4)" "prognostic unfavourable (9.27e-4)" "unprognostic (8.44e-3)" "unprognostic (2.49e-2)" "unprognostic (1.37e-1)" "unprognostic (2.47e-2)" "unprognostic (1.62e-1)" 12.7 14.8 31.4 18.2 46.8 14.9 14.2 30.8 43.5 15.2 26.0 32.6 8.8 33.1 12.4 7.7 40.0 14.3 15.6 9.0 28.4 12.8 13.8 10.0 23.3 17.1 28.6 27.3 27.5 21.5 16.5 15.4 17.4 29.0 14.3 20.7 14.5 21.1 11.3 8.3 47.3 31.1 11.4 24.8 20.0 22.3 14.5 30.9 9.0 12.7 14.6 16.8 14.9 24.1 2.6 1.2 6.4 1.6 0.3 3.0 2.3 18.4 33.9 7.9 12.8 12.6 9.2 22.8 14.8 13.5 11.8 10.0 12.8 12.9 13.2 17.1 15.5 37.6 5.9 26.6 5.8 18.9 16.5 9.4 21.5 10.0 8.3 3.5 18.5 9.8 20.0 11.1 10.3 12.7 10.1 11.5 8.7 11.0 5.6 8.0 6.2 11.0 7.0 6.5 8.0 18.1 19.0 8.3 6.6 15.3 12.8 9.6 11.5 4.9 18.4 12.6 5.7 21.3 14.0 6.6 5.3 2.7 11.3 7.6 8.5 0.0 1.6 6.4 2.7 1.6 3.0 2.6 2.8 2.1 1.2 1.5 2.0 0.8 1.3 0.3 0.8 0.8 2.8 2.3 31.4 46.8 30.8 43.5 28.4 12.8 28.6 27.3 29.0 30.9 MYO3A DFNB30 ENSG00000095777 "Myosin IIIA" Q8NEV4 10 25934071-26212536 "Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Hearing, Sensory transduction, Vision" "Actin-binding, Kinase, Motor protein, Myosin, Serine/threonine-protein kinase, Transferase" "Deafness, Non-syndromic deafness" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "pituitary gland: 8.1;testis: 12.5" "Cell line enhanced" "Detected in some" "AF22: 2.3;CAPAN-2: 2.2;HEK 293: 2.6;SCLC-21H: 2.4;U-2 OS: 4.3;U-698: 10.9" "Low cancer specificity" "Detected in many" "Group enriched" "Detected in many" 4 "basal ganglia: 5.0;cerebral cortex: 1.9;hypothalamus: 1.3;pons and medulla: 5.4" "Cell type enriched" "Detected in single" 12 "naive B-cell: 1.1" "Lineage enriched" "Detected in single" 12 "B-cells: 1.1" "Not detected" "Not detected" "Low region specificity" "Detected in some" "HPA048951, HPA051893" Approved Supported "Plasma membrane,Actin filaments,Cytoplasmic bodies" "Actin filaments, Cytoplasmic bodies" "Plasma membrane" "HPA048951: , HPA051893: " "unprognostic (5.00e-3)" "unprognostic (3.36e-2)" "unprognostic (1.53e-1)" "unprognostic (3.20e-3)" "unprognostic (2.96e-1)" "unprognostic (4.37e-2)" "unprognostic (5.29e-2)" "unprognostic (2.74e-1)" "unprognostic (4.31e-2)" "unprognostic (1.03e-1)" "unprognostic (5.66e-3)" "unprognostic (7.96e-3)" "unprognostic (6.34e-2)" "unprognostic (1.46e-2)" "unprognostic (6.62e-2)" "unprognostic (9.69e-2)" 0.8 0.7 0.4 0.3 5.0 0.5 1.5 0.3 1.9 2.1 0.6 0.1 0.7 0.4 0.3 3.2 0.9 1.1 0.3 0.3 0.5 1.3 0.9 0.2 1.0 0.3 0.2 0.0 0.5 2.1 0.2 8.1 0.2 5.4 0.5 1.1 3.8 0.2 0.6 0.3 2.2 0.6 1.0 0.4 0.3 0.9 12.5 0.8 0.0 1.3 1.4 0.9 0.5 0.9 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.6 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 1.6 0.0 0.0 1.2 0.0 0.0 0.0 2.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.3 0.0 0.0 0.0 0.0 10.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 5.0 0.3 1.9 0.5 1.3 0.2 0.0 5.4 0.8 MYO3B ENSG00000071909 "Myosin IIIB" Q8WXR4 2 170178145-170655171 "Enzymes, Predicted intracellular proteins" "Hearing, Sensory transduction, Vision" "Actin-binding, Kinase, Motor protein, Myosin, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "epididymis: 20.0;parathyroid gland: 12.6;retina: 21.6" "Group enriched" "Detected in some" 10 "HDLM-2: 11.0;HEL: 10.1;RT4: 11.5" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Cell type enhanced" "Detected in some" "gdT-cell: 1.4;naive CD8 T-cell: 1.1" "Lineage enriched" "Detected in single" 5 "T-cells: 1.4" "Region enriched" "Detected in single" 5 "basal ganglia: 4.7" "Not detected" "Not detected" HPA045483 Approved "HPA045483: " "unprognostic (1.65e-1)" "unprognostic (7.87e-2)" "unprognostic (1.96e-2)" "unprognostic (1.43e-2)" "unprognostic (1.67e-1)" "unprognostic (7.15e-3)" "unprognostic (5.07e-2)" "unprognostic (2.61e-2)" "unprognostic (5.84e-3)" "unprognostic (2.12e-1)" "unprognostic (7.99e-3)" "unprognostic (2.59e-1)" "unprognostic (4.25e-5)" "unprognostic (2.34e-1)" "unprognostic (8.12e-3)" "unprognostic (1.18e-1)" "unprognostic (1.07e-1)" 0.2 0.2 0.3 0.0 0.3 0.0 0.2 0.2 0.3 0.6 0.2 0.0 4.6 0.0 0.3 20.0 0.3 0.5 0.0 0.3 0.3 0.5 8.5 0.2 0.3 0.5 0.3 0.3 0.4 2.2 12.6 1.0 0.0 0.3 0.3 0.0 21.6 1.4 1.1 0.2 0.5 0.2 0.5 0.2 0.3 0.2 4.2 0.0 0.0 2.2 0.0 0.8 4.4 0.3 0.1 0.3 0.0 0.0 0.0 1.4 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 11.0 0.0 10.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 1.0 11.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.4 0.0 0.0 0.0 0.0 0.5 0.3 0.1 0.0 1.1 0.0 0.0 0.0 0.0 0.0 0.1 0.3 0.3 0.2 0.3 0.3 0.5 0.3 0.3 0.3 0.0 NRK DKFZp686A17109 ENSG00000123572 "Nik related kinase" Q7Z2Y5 X 105822543-105958610 "Enzymes, Predicted intracellular proteins, Predicted membrane proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "ovary: 42.2;placenta: 64.8" "Cell line enhanced" "Detected in some" "fHDF/TERT166: 32.4;HSkMC: 6.2;RH-30: 7.3;RPTEC TERT1: 19.9" "Cancer enriched" "Detected in some" 8 "testis cancer: 6.1" "Region enriched" "Detected in single" 10 "cerebellum: 4.3" "Not detected" "Not detected" "Not detected" "Not detected" "Region enriched" "Detected in single" 28 "cerebellum: 16.0" "Low region specificity" "Detected in many" HPA017238 Uncertain Approved Nucleoplasm,Cytosol "Nucleoplasm, Cytosol" "HPA017238: AB_1854645" "unprognostic (2.64e-4)" "unprognostic (9.82e-2)" "unprognostic (5.98e-3)" "unprognostic (5.52e-2)" "unprognostic (3.87e-2)" "unprognostic (2.29e-2)" "unprognostic (1.12e-1)" "unprognostic (2.86e-2)" "unprognostic (1.35e-2)" "unprognostic (6.08e-2)" "unprognostic (3.24e-2)" "unprognostic (5.28e-3)" "unprognostic (1.47e-3)" "unprognostic (1.14e-1)" "unprognostic (4.28e-2)" "unprognostic (6.80e-3)" 2.6 12.7 0.4 2.7 0.4 0.0 0.8 4.3 0.3 3.5 1.5 0.1 4.6 0.0 4.3 15.6 1.6 1.3 7.5 2.9 0.4 0.4 9.9 0.4 0.5 0.0 0.3 0.0 42.2 0.5 0.0 2.9 64.8 0.2 22.0 0.1 0.0 2.1 1.6 0.4 0.4 0.5 2.8 0.4 0.3 0.9 10.6 0.0 0.0 0.5 3.1 0.3 1.9 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 32.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 6.2 0.0 0.0 0.0 1.9 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 7.3 0.0 19.9 0.4 0.0 0.1 0.0 1.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.4 4.3 0.3 0.4 0.4 0.3 0.0 0.2 0.0 OXSR1 "KIAA1101, OSR1" ENSG00000172939 "Oxidative stress responsive 1" O95747 3 38165089-38255488 "Enzymes, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA008237, CAB017181" Supported Enhanced Cytosol 21000000 Cytosol "CAB017181: , HPA008237: AB_1079540" "unprognostic (2.16e-1)" "unprognostic (2.36e-2)" "unprognostic (1.79e-2)" "unprognostic (4.55e-3)" "unprognostic (9.89e-2)" "unprognostic (1.97e-2)" "unprognostic (3.53e-3)" "unprognostic (4.05e-2)" "unprognostic (4.44e-1)" "unprognostic (6.06e-2)" "unprognostic (3.95e-3)" "unprognostic (1.88e-2)" "unprognostic (1.87e-3)" "unprognostic (1.56e-1)" "unprognostic (3.14e-2)" "unprognostic (1.71e-1)" "unprognostic (6.99e-3)" 17.6 16.8 9.4 18.3 13.4 24.2 15.9 17.4 14.9 16.8 15.4 9.2 35.7 12.4 14.9 14.7 31.6 11.6 18.9 15.5 11.9 9.0 18.3 17.6 14.6 13.9 13.6 9.3 16.7 12.3 23.7 15.3 21.4 12.3 16.5 16.8 13.0 15.1 23.9 32.6 17.4 21.4 17.0 12.9 15.8 14.0 11.2 13.2 26.2 14.2 24.1 19.6 23.5 19.2 2.3 4.4 10.1 4.8 5.0 4.7 1.6 17.5 8.0 16.1 11.2 11.2 13.0 18.3 15.6 21.4 22.5 24.5 10.3 11.5 19.5 7.9 18.6 10.9 21.6 16.0 29.8 20.6 8.8 21.3 17.1 11.3 13.5 13.1 13.0 10.3 18.9 20.8 33.7 14.0 16.1 11.2 38.5 4.9 25.3 9.5 16.9 9.6 8.8 13.5 15.0 13.9 13.4 8.4 12.9 17.0 43.2 10.6 14.2 8.6 12.7 14.2 14.1 21.5 23.0 8.6 10.2 14.3 19.4 16.4 28.2 10.1 2.8 6.1 3.3 4.8 3.5 1.9 4.0 3.1 4.4 2.3 3.0 3.7 5.5 5.0 4.1 2.5 4.7 1.6 9.4 13.4 17.4 14.9 11.9 9.0 13.6 9.3 12.3 13.2 PAK1 ENSG00000149269 "P21 (RAC1) activated kinase 1" Q13153 11 77321707-77474635 "Enzymes, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins" "Apoptosis, Exocytosis" "Allosteric enzyme, Kinase, Serine/threonine-protein kinase, Transferase" "Disease mutation, Epilepsy, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "blood: 70.0;brain: 71.4" "Cell line enhanced" "Detected in many" "U-266/70: 51.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 9 "classical monocyte: 29.3;eosinophil: 45.0;intermediate monocyte: 28.7;myeloid DC: 42.3;neutrophil: 70.0;non-classical monocyte: 30.4" "Group enriched" "Detected in all" 11 "dendritic cells: 42.3;granulocytes: 70.0;monocytes: 30.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA003565, CAB005312" Enhanced Supported Supported "Plasma membrane,Cytosol" 200000 "Plasma membrane, Cytosol" "CAB005312: AB_2160720, HPA003565: AB_1854935" "unprognostic (1.15e-2)" "unprognostic (3.23e-2)" "prognostic favourable (5.87e-4)" "unprognostic (1.30e-1)" "prognostic unfavourable (1.15e-4)" "unprognostic (6.62e-2)" "unprognostic (8.19e-3)" "unprognostic (4.84e-2)" "unprognostic (1.05e-1)" "unprognostic (1.22e-3)" "unprognostic (1.86e-2)" "unprognostic (2.76e-1)" "unprognostic (1.02e-1)" "unprognostic (6.91e-2)" "unprognostic (1.57e-1)" "unprognostic (4.00e-3)" "unprognostic (1.52e-2)" 5.4 6.0 30.5 13.8 39.5 22.9 7.8 49.1 71.4 9.8 18.2 8.4 2.3 18.2 9.1 13.3 9.9 9.8 13.2 5.3 19.0 16.9 11.3 6.0 6.9 7.5 12.8 40.6 10.4 9.2 11.8 10.8 11.9 39.2 12.2 20.2 5.4 10.4 8.8 34.0 6.7 18.9 11.6 7.8 11.7 17.1 11.1 6.6 7.6 17.7 3.9 9.4 10.5 10.4 2.7 42.3 70.0 30.4 4.3 2.4 12.2 11.8 8.0 17.4 7.8 7.1 11.9 13.9 13.6 9.7 12.9 15.2 11.4 15.9 10.6 5.0 11.7 6.1 12.1 14.4 20.4 12.2 9.8 11.2 5.4 0.7 4.7 18.9 16.6 8.8 8.7 15.1 22.5 3.0 7.4 18.7 23.4 0.8 12.0 8.7 25.7 6.9 18.5 22.5 0.4 3.3 9.9 7.5 7.4 7.3 3.1 5.7 13.9 8.6 0.2 8.6 14.9 45.9 11.3 51.4 26.4 7.0 7.2 12.6 9.3 0.3 29.3 45.0 1.9 28.7 1.5 2.7 1.4 1.8 42.3 1.9 1.3 2.4 70.0 4.3 30.4 3.6 1.1 12.2 30.5 39.5 49.1 71.4 19.0 16.9 12.8 40.6 39.2 6.6 PAK2 "PAK65, PAKgamma" ENSG00000180370 "P21 (RAC1) activated kinase 2" Q13177 3 196739857-196832647 "Enzymes, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins" "Apoptosis, Growth regulation, Host-virus interaction" "Allosteric enzyme, Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" CAB007794 Approved Approved Nucleoplasm,Vesicles 590000 "Nucleoplasm, Vesicles" "CAB007794: AB_562363" "unprognostic (1.03e-2)" "unprognostic (6.34e-2)" "unprognostic (2.52e-1)" "unprognostic (2.50e-2)" "unprognostic (1.32e-1)" "unprognostic (1.80e-1)" "unprognostic (5.18e-3)" "unprognostic (1.85e-2)" "unprognostic (7.97e-2)" "unprognostic (1.09e-1)" "prognostic unfavourable (3.36e-4)" "prognostic unfavourable (9.58e-4)" "unprognostic (1.30e-3)" "unprognostic (4.57e-2)" "unprognostic (1.25e-2)" "unprognostic (1.70e-2)" "unprognostic (3.39e-1)" 28.7 18.9 22.4 27.6 23.5 21.4 56.5 17.4 20.7 19.5 23.0 27.8 17.4 19.0 22.6 19.2 23.4 17.9 20.7 29.0 22.6 22.0 19.5 34.3 35.7 50.2 26.8 13.5 19.9 16.6 30.5 13.0 27.6 22.8 17.7 23.0 12.9 19.6 21.2 34.2 16.3 25.2 23.0 32.1 34.6 18.4 15.9 24.8 44.9 16.9 19.1 31.9 24.1 32.7 6.6 13.7 25.9 12.6 6.6 10.8 7.0 35.2 12.6 17.8 13.0 12.6 16.7 26.4 17.9 14.8 19.5 17.8 29.9 18.1 22.6 51.2 18.1 18.1 18.8 17.0 30.2 10.1 9.1 33.5 14.5 23.5 25.6 32.5 32.2 13.3 14.0 17.4 37.1 19.2 16.1 28.2 18.9 37.2 30.9 16.8 10.6 19.0 28.3 10.1 20.5 17.0 24.8 10.4 11.8 23.9 16.9 13.5 59.3 23.6 19.8 16.2 9.0 16.9 26.3 19.2 33.9 55.7 13.4 32.6 15.3 16.5 10.3 24.5 6.3 12.6 8.5 6.4 7.3 7.1 13.7 6.6 5.4 6.3 25.9 6.6 10.8 5.1 10.8 7.0 22.4 23.5 17.4 20.7 22.6 22.0 26.8 13.5 22.8 24.8 PAK3 "bPAK, hPAK3, MRX30, MRX47" ENSG00000077264 "P21 (RAC1) activated kinase 3" O75914 X 110944285-111227361 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins" "Allosteric enzyme, Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase" "Disease mutation, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 4 "brain: 26.2;pancreas: 46.5;pituitary gland: 37.2" "Cell line enhanced" "Detected in some" "EFO-21: 9.7;HAP1: 8.7;HDLM-2: 10.9;NTERA-2: 8.5;SCLC-21H: 11.1;SH-SY5Y: 6.9;U-2197: 6.7;U-251 MG: 11.6" "Low cancer specificity" "Detected in some" "Low region specificity" "Detected in all" "Cell type enriched" "Detected in single" 6 "MAIT T-cell: 4.3" "Lineage enriched" "Detected in single" 7 "T-cells: 4.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA044791, HPA060219" Approved Approved Cytosol Cytosol "HPA044791: , HPA060219: " "unprognostic (1.80e-2)" "unprognostic (1.54e-1)" "unprognostic (1.80e-2)" "unprognostic (3.27e-4)" "unprognostic (2.46e-1)" "unprognostic (5.63e-3)" "unprognostic (7.29e-2)" "unprognostic (3.23e-2)" "unprognostic (1.27e-2)" "unprognostic (3.01e-1)" "unprognostic (6.80e-3)" "unprognostic (1.66e-1)" "unprognostic (1.89e-4)" "unprognostic (5.71e-3)" "unprognostic (6.81e-2)" "unprognostic (1.06e-1)" "unprognostic (3.30e-2)" 2.0 6.8 17.6 2.5 17.5 1.0 6.4 1.8 24.6 3.7 1.6 0.9 9.1 1.0 6.8 7.6 1.7 3.7 2.6 1.2 26.2 20.8 1.6 1.1 1.8 2.5 7.9 21.9 7.9 46.5 0.9 37.2 1.6 12.9 4.8 1.7 1.4 3.0 7.1 2.4 2.0 1.4 6.1 5.8 2.9 3.0 3.6 1.9 0.0 7.7 0.0 1.7 2.0 1.5 0.1 0.1 0.6 0.1 0.2 4.3 0.0 0.0 0.6 1.3 0.0 0.0 0.0 0.0 0.2 0.3 0.9 0.0 0.0 0.0 0.0 9.7 1.0 0.0 8.7 0.5 1.2 10.9 0.3 0.0 1.0 0.0 0.0 0.0 0.3 0.2 0.0 0.1 2.0 0.0 0.0 0.4 0.0 0.0 0.1 0.1 8.5 1.9 0.1 4.0 0.0 0.8 0.0 11.1 6.9 0.0 0.4 0.0 0.0 0.0 0.0 0.6 4.3 6.7 11.6 0.0 0.1 0.1 1.2 0.0 0.1 0.6 0.1 0.1 0.1 0.0 4.3 0.0 0.7 0.4 0.0 0.1 0.1 0.1 0.5 0.2 0.1 0.1 0.3 0.0 17.6 17.5 1.8 18.5 26.2 20.8 7.9 21.9 12.9 1.9 PAK4 ENSG00000130669 "P21 (RAC1) activated kinase 4" O96013 19 39125770-39182816 "Enzymes, Predicted intracellular proteins, RAS pathway related proteins" "Apoptosis, Cell cycle" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell line enhanced" "Detected in all" "A549: 44.6;MCF7: 49.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB025747, CAB044670, HPA070175, HPA072220" Uncertain Supported "Plasma membrane,Cell Junctions" "Plasma membrane, Cell Junctions" "CAB025747: , CAB044670: AB_1854940, HPA070175: AB_2686232, HPA072220: AB_2686497" "unprognostic (1.71e-1)" "unprognostic (2.84e-1)" "unprognostic (5.86e-2)" "unprognostic (2.84e-2)" "unprognostic (1.93e-1)" "unprognostic (8.51e-2)" "unprognostic (3.56e-3)" "unprognostic (1.13e-3)" "unprognostic (3.90e-2)" "unprognostic (4.04e-2)" "unprognostic (7.29e-2)" "prognostic unfavourable (9.85e-4)" "prognostic favourable (5.29e-5)" "unprognostic (2.39e-1)" "unprognostic (7.05e-2)" "unprognostic (2.02e-1)" "unprognostic (4.85e-2)" 6.8 11.1 11.0 12.7 12.3 4.8 11.9 13.7 12.4 17.3 19.6 13.7 19.9 26.0 12.2 17.3 20.1 15.3 16.5 8.1 10.9 8.1 19.4 17.0 18.7 5.4 13.7 7.7 13.8 29.6 11.2 17.0 23.0 10.3 29.6 8.1 19.7 40.9 18.5 10.3 18.6 25.1 9.0 8.3 7.9 18.6 22.3 12.5 8.8 15.2 10.1 14.7 11.5 15.0 2.8 3.4 4.2 2.5 3.6 4.5 1.9 17.6 44.6 6.6 10.1 2.1 2.2 20.1 8.4 3.4 5.7 5.7 29.2 15.0 4.0 12.8 5.3 6.5 3.6 6.7 2.1 10.7 10.2 4.8 8.1 14.2 3.4 4.8 7.0 2.7 3.0 5.3 3.8 7.4 9.5 3.2 3.4 49.1 5.1 5.3 12.1 10.7 5.2 5.2 3.0 5.5 19.4 21.3 14.7 8.6 38.3 9.5 17.0 8.0 12.3 9.7 16.7 11.1 15.0 3.6 3.4 3.3 11.9 2.9 11.6 1.0 2.5 4.2 2.6 1.4 3.6 2.2 2.9 4.5 3.4 2.8 2.2 2.2 2.1 3.6 2.1 2.9 3.0 1.9 11.0 12.3 13.7 12.4 10.9 8.1 13.7 7.7 10.3 12.5 PAK5 "KIAA1264, PAK7" ENSG00000101349 "P21 (RAC1) activated kinase 5" Q9P286 20 9537389-9839041 "Enzymes, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins" Apoptosis "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 6 "brain: 30.3" "Group enriched" "Detected in some" 9 "SCLC-21H: 10.0;SH-SY5Y: 3.7" "Low cancer specificity" "Detected in single" "Low region specificity" "Detected in all" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA020444 Approved Approved Nucleoplasm Nucleoplasm "HPA020444: AB_1854947" "unprognostic (5.14e-5)" "unprognostic (3.35e-1)" "unprognostic (1.05e-1)" "unprognostic (8.63e-2)" "unprognostic (3.21e-1)" "unprognostic (3.04e-1)" "unprognostic (2.25e-4)" "unprognostic (3.76e-1)" "unprognostic (2.56e-2)" "unprognostic (3.83e-1)" "unprognostic (3.35e-2)" "unprognostic (6.04e-2)" "unprognostic (4.58e-1)" 0.5 5.2 5.7 0.6 11.7 0.5 1.6 30.3 19.6 0.8 0.6 0.8 0.0 0.7 1.0 2.2 1.0 0.7 3.4 0.6 4.0 3.3 1.0 2.3 0.7 0.6 1.6 8.8 0.6 3.5 0.5 2.0 0.6 5.3 1.6 0.6 0.6 1.2 1.6 0.6 1.6 0.6 0.6 1.2 0.6 1.2 1.0 1.7 0.0 0.6 0.0 0.6 0.5 0.2 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.4 0.1 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 10.0 3.7 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.2 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.1 0.0 0.0 0.6 0.2 0.0 0.0 0.0 0.0 0.2 0.0 5.7 11.7 30.3 13.6 4.0 3.3 1.6 8.8 5.3 1.7 PAK6 PAK5 ENSG00000137843 "P21 (RAC1) activated kinase 6" Q9NQU5 15 40238759-40277487 "Enzymes, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "skin 1: 22.2" "Cell line enhanced" "Detected in many" "CACO-2: 14.5;HaCaT: 22.5;hTCEpi: 13.8;SK-BR-3: 7.6" "Not detected" "Not detected" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in many" HPA031124 Approved Approved "Nucleoplasm,Nucleoli fibrillar center,Cell Junctions" "Nucleoplasm, Nucleoli fibrillar center" "Cell Junctions" "HPA031124: AB_10601044" "unprognostic (1.85e-3)" "unprognostic (2.15e-1)" "unprognostic (3.33e-3)" "unprognostic (7.79e-3)" "unprognostic (7.08e-3)" "unprognostic (9.57e-2)" "unprognostic (2.71e-1)" "unprognostic (7.73e-2)" "unprognostic (1.34e-2)" "unprognostic (7.13e-3)" "unprognostic (4.04e-2)" "unprognostic (8.87e-3)" "unprognostic (1.72e-1)" "unprognostic (1.79e-1)" "unprognostic (7.37e-3)" "unprognostic (3.34e-2)" 0.3 5.3 14.7 0.8 18.4 0.8 2.3 11.3 20.1 3.0 1.3 1.6 2.5 1.4 1.0 1.1 15.8 4.3 1.4 7.9 11.6 5.2 3.4 0.4 2.6 1.0 3.0 10.9 0.6 7.4 12.9 6.4 8.1 2.1 3.6 1.2 0.3 3.4 7.5 3.5 22.2 1.4 0.8 1.2 1.0 3.6 12.8 2.2 0.0 7.4 8.5 5.1 3.0 5.1 1.4 0.7 2.9 0.7 2.0 5.5 1.2 2.6 0.0 0.2 0.1 0.0 0.0 4.3 0.0 0.1 0.6 0.4 14.5 2.0 0.1 2.3 0.0 22.5 3.2 4.8 0.2 0.1 0.7 0.0 1.9 0.1 0.0 0.1 0.3 0.0 13.8 0.2 3.2 0.0 1.1 0.2 0.0 3.1 0.0 0.3 0.4 2.0 0.2 0.1 1.8 1.1 5.9 5.2 1.3 1.8 7.6 0.2 0.8 7.0 0.0 0.2 0.4 0.0 0.1 0.0 0.2 0.0 0.5 0.3 0.1 2.1 0.7 2.9 5.5 0.3 2.1 1.4 0.5 4.2 0.7 0.5 0.3 1.2 1.3 2.0 0.2 0.5 0.1 1.2 14.7 18.4 11.3 20.1 11.6 5.2 3.0 10.9 2.1 2.2 PBK "CT84, FLJ14385, Nori-3, SPK, TOPK" ENSG00000168078 "PDZ binding kinase" Q96KB5 8 27809620-27838095 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 7 "lymphoid tissue: 19.4;testis: 67.9" "Cell line enhanced" "Detected in many" "A-431: 60.7" "Low cancer specificity" "Detected in all" "Not detected" "Not detected" "Cell type enhanced" "Detected in some" "NK-cell: 2.1;T-reg: 1.6" "Group enriched" "Detected in many" 10 "NK-cells: 2.1;T-cells: 1.6" "Low region specificity" "Detected in single" "Low region specificity" "Detected in all" "HPA005753, HPA050656" Enhanced Supported Approved Cytosol Cytosol "HPA005753: AB_1855018, HPA050656: AB_2681205" "unprognostic (7.17e-2)" "unprognostic (7.21e-3)" "unprognostic (1.04e-3)" "unprognostic (2.77e-2)" "unprognostic (1.50e-1)" "unprognostic (1.27e-1)" "prognostic unfavourable (8.29e-5)" "unprognostic (3.65e-3)" "unprognostic (7.38e-2)" "unprognostic (2.88e-3)" "prognostic unfavourable (6.56e-4)" "unprognostic (1.20e-1)" "prognostic unfavourable (1.18e-12)" "unprognostic (9.61e-2)" "unprognostic (1.86e-1)" "unprognostic (8.30e-2)" "unprognostic (8.68e-2)" 0.6 0.8 0.2 7.7 0.3 3.3 1.3 0.3 0.4 1.1 3.8 0.3 0.2 3.7 0.4 0.6 6.2 0.3 0.8 3.3 0.3 0.2 0.7 0.9 1.2 5.4 0.3 0.2 0.4 0.4 0.0 0.2 2.2 0.3 0.4 4.6 0.2 1.1 0.2 0.4 1.9 3.6 0.9 0.6 1.7 1.7 67.9 0.2 19.4 0.3 4.7 5.3 0.7 1.9 0.1 0.0 0.0 0.0 2.1 1.6 0.5 60.7 19.8 19.5 12.3 1.9 3.4 8.2 27.9 13.3 28.8 24.3 6.9 11.3 32.4 9.9 10.7 16.1 18.7 9.4 31.6 7.9 10.2 7.8 14.1 10.0 0.1 5.0 11.6 0.9 7.7 13.3 7.1 14.5 11.4 21.8 33.9 6.9 19.2 5.9 3.5 17.2 12.0 27.2 8.7 10.8 9.4 7.7 12.1 10.4 12.2 15.6 12.9 7.7 8.4 18.9 45.6 23.9 29.6 3.1 8.6 15.0 11.5 8.9 40.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 1.3 0.0 0.1 0.0 0.1 0.0 2.1 0.0 0.0 1.6 0.5 0.2 0.3 0.3 0.4 0.3 0.2 0.3 0.2 0.3 0.2 SLK "KIAA0204, se20-9, STK2" ENSG00000065613 "STE20 like kinase" Q9H2G2 10 103967201-104029233 "Enzymes, Plasma proteins, Predicted intracellular proteins" Apoptosis "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA015757 Approved Approved "Plasma membrane,Cytosol" 17000 "Plasma membrane, Cytosol" "HPA015757: AB_1857236" "unprognostic (1.89e-1)" "unprognostic (1.80e-1)" "unprognostic (1.38e-1)" "unprognostic (8.28e-2)" "unprognostic (1.01e-1)" "unprognostic (3.64e-1)" "unprognostic (8.67e-2)" "unprognostic (6.85e-2)" "unprognostic (1.01e-1)" "unprognostic (2.31e-1)" "prognostic unfavourable (2.77e-5)" "unprognostic (1.95e-1)" "prognostic favourable (3.95e-5)" "unprognostic (8.48e-2)" "unprognostic (3.95e-1)" "unprognostic (3.09e-2)" "unprognostic (1.07e-1)" 15.2 11.2 13.7 11.0 36.7 14.6 16.1 16.7 13.1 16.6 19.0 9.9 10.9 9.1 17.0 12.1 40.2 12.1 13.6 17.2 10.6 7.1 14.9 12.2 17.1 10.1 11.2 13.4 17.2 12.5 22.6 13.1 17.4 12.8 19.3 13.6 11.4 19.8 12.7 19.3 16.6 15.5 29.8 13.0 12.1 15.7 10.2 12.8 12.0 15.8 21.6 12.5 24.9 23.6 1.4 2.2 6.5 1.4 1.3 3.6 0.7 21.2 12.4 14.9 10.6 16.1 22.5 6.3 13.3 17.7 9.9 9.3 7.9 22.9 11.3 8.3 13.7 23.2 7.8 16.8 14.5 9.0 10.8 11.5 10.2 6.6 12.1 13.7 10.0 11.5 22.1 13.4 39.2 17.8 14.3 7.8 13.0 7.4 9.6 7.6 3.7 8.0 9.4 18.3 5.8 13.0 24.5 3.5 6.1 11.5 11.2 11.0 5.8 9.9 26.9 7.3 7.6 13.4 15.5 9.5 11.6 7.2 10.8 18.4 4.7 1.2 1.4 3.3 3.6 1.2 3.6 1.1 2.2 2.2 1.2 1.4 1.5 2.5 6.5 1.3 1.0 2.2 1.4 0.7 13.7 36.7 16.7 13.1 10.6 7.1 11.2 13.4 12.8 12.8 STK10 "LOK, PRO2729" ENSG00000072786 "Serine/threonine kinase 10" O94804 5 172042073-172188386 "Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Cell cycle" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "lymphoid tissue: 40.9" "Cell line enhanced" "Detected in all" "WM-115: 51.5" "Low cancer specificity" "Detected in all" "Region enriched" "Detected in all" 5 "cerebellum: 27.5" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA015083, CAB020840" Enhanced Approved "Nucleoplasm,Plasma membrane" 24000 "Nucleoplasm, Plasma membrane" "CAB020840: , HPA015083: " "unprognostic (1.17e-1)" "unprognostic (5.43e-2)" "prognostic favourable (2.76e-4)" "unprognostic (2.88e-1)" "unprognostic (6.96e-3)" "unprognostic (1.02e-1)" "unprognostic (5.25e-3)" "unprognostic (3.07e-2)" "unprognostic (1.07e-1)" "unprognostic (1.03e-1)" "unprognostic (2.65e-1)" "unprognostic (3.43e-1)" "prognostic unfavourable (1.63e-4)" "unprognostic (1.09e-1)" "unprognostic (1.01e-2)" "unprognostic (3.10e-1)" "unprognostic (1.84e-1)" 15.0 4.7 2.6 25.8 4.4 38.3 13.5 27.5 3.0 3.6 5.0 4.8 3.4 4.7 4.4 4.4 3.6 4.2 11.0 9.0 2.4 2.5 5.3 4.5 15.4 40.9 5.4 1.9 3.5 4.1 2.5 3.7 16.2 4.5 4.3 4.0 5.6 7.8 2.5 3.1 9.0 12.2 5.7 4.6 33.0 6.2 13.1 3.5 20.6 4.6 3.1 23.7 9.5 11.3 5.0 10.3 22.3 30.8 7.4 18.0 15.6 7.7 7.2 4.5 6.7 5.2 6.5 11.5 10.1 8.4 7.3 6.8 3.7 10.2 9.3 5.4 12.4 9.0 2.0 12.3 4.8 12.2 3.3 11.2 3.0 2.1 7.5 11.3 13.3 6.4 2.6 9.9 8.3 6.3 1.0 13.1 5.1 12.4 8.1 25.5 1.8 5.7 13.4 3.5 6.2 3.0 9.8 3.0 3.7 5.8 8.1 27.6 2.9 24.0 8.7 8.2 4.1 5.7 5.4 11.1 16.3 5.9 10.8 17.5 51.5 7.1 10.8 10.0 18.0 21.4 13.3 5.0 9.4 12.8 10.3 4.4 5.6 9.6 22.3 7.4 30.8 3.2 12.2 15.6 2.6 4.4 27.5 3.0 2.4 2.5 5.4 1.9 4.5 3.5 STK24 "MST-3, MST3, MST3B, STE20, STK3" ENSG00000102572 "Serine/threonine kinase 24" Q9Y6E0 13 98445185-98577940 "Enzymes, Predicted intracellular proteins" Apoptosis "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA026435, HPA026502" Enhanced Supported Nucleoli,Cytosol 2800000 "Nucleoli, Cytosol" "HPA026435: AB_1854151, HPA026502: AB_1854152" "unprognostic (3.49e-2)" "unprognostic (2.39e-2)" "unprognostic (1.78e-1)" "unprognostic (3.44e-2)" "unprognostic (2.86e-1)" "unprognostic (3.25e-2)" "unprognostic (9.67e-3)" "prognostic unfavourable (6.23e-6)" "unprognostic (5.45e-2)" "unprognostic (1.13e-1)" "prognostic unfavourable (5.81e-4)" "unprognostic (9.62e-2)" "prognostic favourable (6.91e-5)" "unprognostic (3.10e-2)" "unprognostic (4.49e-2)" "unprognostic (3.88e-2)" "unprognostic (1.12e-2)" 28.6 14.2 15.0 29.7 16.9 19.1 34.8 12.2 21.0 36.3 37.4 12.1 23.0 31.9 24.6 26.5 68.4 20.4 41.3 30.0 14.7 12.8 30.5 14.2 23.9 31.2 10.6 10.1 20.0 20.6 12.4 13.9 38.4 14.7 28.3 28.8 36.8 30.8 21.6 18.8 60.6 67.9 34.8 9.2 31.7 30.2 22.1 7.6 38.2 28.2 41.6 48.5 39.2 45.4 8.1 11.2 11.4 13.4 1.5 13.7 6.7 36.0 11.2 20.0 18.5 30.8 18.4 28.4 16.9 23.8 23.7 23.2 32.9 49.0 25.7 8.6 21.1 32.7 18.5 37.2 22.7 64.0 9.5 27.4 14.4 18.8 43.5 27.6 19.5 11.9 59.5 18.6 54.8 20.3 9.9 17.8 15.5 15.7 20.6 11.4 17.9 8.5 26.1 12.3 13.9 22.8 32.6 11.7 16.8 10.7 17.2 22.8 20.8 26.9 27.4 15.1 11.0 12.3 19.4 17.4 9.1 9.6 23.5 16.7 24.8 5.8 13.4 6.1 6.1 10.6 7.2 6.6 11.4 8.7 11.2 8.1 7.8 6.1 11.4 1.5 12.7 7.5 13.7 6.7 15.0 16.9 12.2 21.0 14.7 12.8 10.6 10.1 14.7 7.6 STK25 "SOK1, YSK1" ENSG00000115694 "Serine/threonine kinase 25" O00506 2 241492674-241509730 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in all" 5 "skeletal muscle: 164.2" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA047147 Uncertain "HPA047147: AB_10966137" "unprognostic (1.75e-1)" "unprognostic (8.29e-2)" "prognostic unfavourable (6.03e-4)" "unprognostic (3.42e-2)" "unprognostic (2.71e-1)" "unprognostic (1.24e-1)" "prognostic unfavourable (3.91e-8)" "unprognostic (6.16e-2)" "unprognostic (7.15e-3)" "unprognostic (1.11e-1)" "unprognostic (2.58e-3)" "unprognostic (1.55e-1)" "unprognostic (2.47e-2)" "unprognostic (2.00e-1)" "unprognostic (1.37e-1)" "unprognostic (3.19e-1)" "unprognostic (4.58e-1)" 17.8 13.6 22.3 14.2 26.0 16.3 12.9 22.3 35.3 16.4 17.1 17.0 13.0 14.6 17.7 15.9 19.3 15.4 16.7 19.0 19.4 20.0 17.3 13.5 13.4 13.5 16.3 20.4 17.5 19.2 18.9 17.1 15.6 16.4 15.1 12.9 13.5 14.2 17.6 164.2 15.3 14.2 17.3 12.6 15.8 16.1 16.8 14.4 15.2 20.0 24.6 12.6 14.6 16.6 15.0 13.6 13.7 16.4 21.5 19.9 10.6 18.3 11.7 23.4 29.0 28.8 20.1 36.0 30.7 20.7 23.4 26.8 13.0 16.2 7.0 8.7 40.9 15.7 32.9 33.4 28.5 26.2 34.5 19.6 24.8 33.6 26.1 11.9 15.1 28.9 24.0 22.6 18.2 52.8 30.2 6.2 42.8 19.3 17.6 18.5 32.6 16.8 29.7 29.8 10.4 20.6 15.6 39.3 18.0 14.9 11.3 19.2 9.0 21.1 61.5 17.7 21.7 20.3 21.7 12.9 2.9 11.9 17.1 9.8 20.0 13.7 14.8 11.5 16.9 13.4 15.5 14.5 15.5 17.5 13.6 15.0 12.0 11.6 5.5 21.5 16.4 10.7 19.9 10.6 22.3 26.0 22.3 35.3 19.4 20.0 16.3 20.4 16.4 14.4 STK26 "MASK, MST4" ENSG00000134602 "Serine/threonine kinase 26" Q9P289 X 132023265-132075943 "Enzymes, Predicted intracellular proteins" Apoptosis "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell line enhanced" "Detected in many" "U-937: 40.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA059921 Approved Uncertain "Nucleoplasm,Golgi apparatus,Centrosome,Cytosol" Nucleoplasm "Golgi apparatus, Centrosome, Cytosol" "HPA059921: " "unprognostic (6.53e-2)" "unprognostic (7.83e-2)" "unprognostic (1.77e-1)" "unprognostic (1.02e-3)" "unprognostic (4.42e-1)" "unprognostic (1.03e-2)" "prognostic unfavourable (6.82e-4)" "unprognostic (1.18e-1)" "unprognostic (1.93e-1)" "unprognostic (1.31e-1)" "unprognostic (1.42e-3)" "unprognostic (2.49e-1)" "prognostic unfavourable (6.87e-5)" "unprognostic (4.76e-2)" "unprognostic (1.83e-1)" "unprognostic (1.77e-1)" "unprognostic (2.88e-1)" 5.4 1.4 1.1 13.5 5.1 25.9 3.3 3.8 1.1 18.0 6.4 0.3 34.8 3.7 42.3 29.6 11.7 6.0 5.2 1.9 1.2 2.3 3.5 3.2 6.7 12.8 1.2 0.3 4.7 4.0 10.2 5.8 50.7 1.2 11.5 4.8 2.2 6.3 22.4 1.2 5.1 6.1 19.1 1.5 8.5 4.7 5.2 0.8 44.7 2.3 6.8 10.2 18.0 6.6 8.4 6.2 26.4 11.6 22.0 13.3 10.2 9.0 3.1 0.3 0.0 1.5 1.4 20.7 0.3 1.1 0.1 0.1 8.3 8.2 12.3 5.6 2.0 10.3 23.0 14.4 0.0 10.6 18.8 17.7 7.8 7.8 1.4 37.0 1.4 2.0 8.6 0.0 9.8 4.0 7.8 11.6 3.4 7.9 38.0 34.4 18.4 1.2 27.5 11.4 15.8 9.3 14.5 7.7 8.5 5.4 4.9 0.2 6.3 9.8 0.1 3.7 4.0 11.2 13.2 8.9 14.0 13.7 3.4 40.3 1.8 26.4 5.1 16.6 13.3 6.7 13.0 8.4 9.1 11.3 6.2 7.3 11.8 12.2 10.0 22.0 11.6 2.3 4.0 10.2 1.1 5.1 3.8 1.1 1.2 2.3 1.2 0.3 1.2 0.8 STK3 "KRS1, MST2" ENSG00000104375 "Serine/threonine kinase 3" Q13188 8 98401403-98942827 "Enzymes, Plasma proteins, Predicted intracellular proteins" Apoptosis "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell line enhanced" "Detected in many" "A-431: 37.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Group enriched" "Detected in all" 5 "dendritic cells: 8.3;granulocytes: 9.0;monocytes: 8.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA007120, CAB025316" Uncertain Approved "Intermediate filaments,Rods & Rings" "Intermediate filaments, Rods & Rings" "CAB025316: , HPA007120: AB_10601664" "unprognostic (7.88e-3)" "unprognostic (1.96e-1)" "unprognostic (6.57e-2)" "prognostic unfavourable (1.53e-4)" "unprognostic (2.95e-1)" "unprognostic (1.12e-3)" "unprognostic (9.68e-3)" "prognostic unfavourable (4.25e-4)" "unprognostic (6.71e-2)" "unprognostic (9.83e-2)" "prognostic unfavourable (9.21e-5)" "unprognostic (9.16e-2)" "unprognostic (1.03e-1)" "unprognostic (2.27e-1)" "unprognostic (1.29e-1)" "unprognostic (5.86e-2)" "unprognostic (9.72e-2)" 16.5 16.6 6.5 8.1 12.4 2.5 20.5 2.6 10.6 17.2 13.1 10.5 14.2 4.6 22.2 13.1 9.0 16.0 12.6 10.0 7.4 4.1 14.7 12.0 16.2 10.8 12.8 3.6 22.8 10.7 15.1 18.9 53.1 9.9 15.0 6.0 8.2 10.8 16.4 11.6 10.0 10.8 23.5 12.9 8.2 9.5 10.1 11.4 3.4 10.6 7.9 5.9 16.4 24.3 1.9 8.3 9.0 8.7 1.8 1.8 2.9 37.6 7.1 7.5 9.9 24.4 12.2 7.5 13.1 11.8 12.3 10.7 5.2 16.0 0.0 11.4 13.0 15.3 5.2 11.3 19.9 9.0 6.7 10.1 3.5 3.5 8.3 3.3 8.8 8.1 19.5 6.3 17.2 5.2 4.2 5.5 8.9 4.7 8.4 4.0 2.2 2.8 7.4 6.5 3.2 14.0 4.7 1.9 4.4 8.3 9.6 8.1 7.9 5.5 3.9 8.3 5.3 12.5 7.2 4.4 6.5 2.7 7.4 4.2 13.1 2.1 8.6 4.5 1.3 8.7 1.4 1.9 0.8 1.8 8.3 1.3 1.1 0.7 9.0 1.8 5.4 3.4 0.1 2.9 6.5 12.4 2.6 10.6 7.4 4.1 12.8 3.6 9.9 11.4 STK39 "DCHT, SPAK" ENSG00000198648 "Serine/threonine kinase 39" Q9UEW8 2 167954020-168248141 "Enzymes, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "testis: 35.5" "Low cell line specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB046022, HPA061803, HPA062802" Enhanced Supported Nucleoplasm,Vesicles,Cytosol Nucleoplasm "Vesicles, Cytosol" "CAB046022: AB_2196960, HPA061803: , HPA062802: " "prognostic favourable (3.96e-4)" "unprognostic (2.97e-2)" "unprognostic (4.40e-2)" "unprognostic (4.22e-2)" "unprognostic (4.36e-1)" "unprognostic (6.14e-2)" "prognostic unfavourable (5.67e-5)" "unprognostic (3.04e-2)" "unprognostic (8.86e-2)" "unprognostic (9.43e-2)" "unprognostic (3.20e-2)" "unprognostic (1.38e-1)" "unprognostic (2.06e-1)" "unprognostic (9.45e-2)" "unprognostic (8.61e-3)" "unprognostic (1.14e-1)" "unprognostic (6.20e-3)" 6.2 2.1 8.4 4.6 11.0 1.3 3.5 9.3 14.1 4.3 9.1 8.3 1.7 10.5 2.3 4.7 14.1 1.9 5.9 7.6 9.8 7.4 2.9 0.8 2.4 7.3 12.3 9.7 3.2 9.9 5.0 8.2 1.2 14.2 9.9 11.7 7.1 22.8 3.8 2.2 3.4 6.1 4.3 19.0 2.5 11.2 35.5 5.5 7.2 2.2 1.8 8.0 5.6 5.3 0.7 1.0 0.0 0.7 1.9 3.4 0.5 6.6 4.0 15.2 4.8 9.4 13.8 1.5 16.7 12.3 11.2 10.4 0.0 21.6 18.3 4.6 10.8 17.3 9.7 12.2 14.1 5.8 6.0 7.6 4.4 13.5 17.4 10.2 0.8 9.5 17.3 13.3 13.9 7.6 0.1 0.0 23.4 3.8 17.7 3.6 10.5 8.5 25.4 6.0 1.5 8.4 16.5 22.5 9.5 5.8 0.8 6.8 3.0 7.5 7.1 13.6 4.2 9.6 10.9 0.0 0.0 14.7 10.3 9.1 9.1 0.0 0.7 0.0 2.5 0.4 1.3 0.7 1.9 3.4 1.0 0.7 0.4 2.0 0.0 1.9 0.3 0.3 3.3 0.5 8.4 11.0 9.3 14.1 9.8 7.4 12.3 9.7 14.2 5.5 STK4 "KRS2, MST1, YSK3" ENSG00000101109 "Serine/threonine kinase 4" Q13043 20 44966474-45079959 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins" Apoptosis "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004038, HPA015270" Approved Supported "Nucleoplasm,Nuclear bodies,Cytosol" "Nuclear bodies" "Nucleoplasm, Cytosol" "CAB004038: AB_2144632, HPA015270: AB_1854150" "unprognostic (2.77e-1)" "unprognostic (1.10e-1)" "unprognostic (8.83e-2)" "unprognostic (8.49e-3)" "unprognostic (2.95e-2)" "unprognostic (1.24e-1)" "prognostic unfavourable (8.04e-4)" "unprognostic (1.70e-1)" "unprognostic (2.51e-1)" "unprognostic (1.05e-1)" "unprognostic (1.96e-1)" "unprognostic (2.70e-2)" "prognostic unfavourable (1.84e-5)" "unprognostic (1.28e-1)" "unprognostic (5.70e-2)" "unprognostic (3.96e-1)" "unprognostic (1.18e-2)" 9.5 8.8 10.4 24.5 11.5 39.5 8.1 7.5 13.4 7.8 8.6 10.3 5.4 8.1 9.3 6.5 8.9 7.3 9.4 6.1 9.3 8.8 6.3 7.4 18.8 30.6 10.5 9.1 8.3 6.4 5.9 9.3 8.2 7.7 7.5 10.6 7.4 9.3 8.7 4.2 11.4 16.1 8.2 12.0 29.1 9.6 7.4 9.6 32.3 8.0 4.9 36.6 11.5 8.7 10.8 6.9 40.6 13.3 10.3 14.5 7.9 11.6 7.9 10.1 7.2 6.2 7.8 7.0 10.3 15.8 17.5 15.9 22.4 6.4 28.6 9.0 7.3 12.4 10.7 13.8 22.5 12.8 5.7 20.8 11.6 15.7 10.9 26.7 29.6 6.3 11.4 16.4 17.9 6.4 9.6 16.5 8.8 9.2 19.9 18.1 6.2 5.4 12.9 11.2 13.3 6.4 8.0 4.8 5.9 15.3 8.9 11.7 8.1 16.9 8.2 13.2 12.9 15.2 11.9 21.6 16.9 31.8 12.9 12.8 9.7 24.4 7.6 20.5 14.5 7.7 14.4 10.3 13.8 13.3 6.9 10.8 14.3 11.9 40.6 10.3 13.3 3.9 13.3 7.9 10.4 11.5 7.5 13.4 9.3 8.8 10.5 9.1 7.7 9.6 STRADA "LYK5, NY-BR-96, Stlk, STRAD" ENSG00000266173 "STE20-related kinase adaptor alpha" Q7RTN6 17 63682336-63741986 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" "Cell cycle" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA031637 Approved Supported Nucleoplasm,Cytosol "Nucleoplasm, Cytosol" "HPA031637: AB_10601718" "unprognostic (1.59e-1)" "unprognostic (2.19e-1)" "unprognostic (5.59e-3)" "unprognostic (5.52e-2)" "unprognostic (8.91e-2)" "unprognostic (7.56e-5)" "unprognostic (6.79e-4)" "unprognostic (3.68e-2)" "unprognostic (1.70e-1)" "unprognostic (2.28e-1)" "prognostic favourable (5.34e-5)" "unprognostic (7.29e-2)" "prognostic unfavourable (6.08e-7)" "unprognostic (1.40e-1)" "unprognostic (1.44e-1)" "unprognostic (1.25e-1)" "prognostic favourable (6.43e-4)" 13.3 17.7 19.4 14.6 23.7 17.5 13.0 25.0 28.4 15.2 13.2 27.1 8.7 9.5 16.1 20.6 14.3 20.9 14.5 15.1 18.9 20.2 14.7 13.0 13.9 19.6 20.9 21.7 18.5 12.5 21.9 17.5 14.4 26.0 13.8 13.1 22.2 12.6 16.7 10.3 20.1 12.0 19.1 19.4 20.7 12.6 55.4 21.4 16.2 13.3 8.9 21.3 12.9 12.8 11.2 16.2 18.6 10.0 15.6 11.7 7.5 7.2 21.7 18.9 19.0 18.6 13.9 7.4 13.8 12.7 19.9 17.8 5.6 8.4 11.0 8.6 11.7 6.0 12.5 13.3 19.8 12.2 12.1 21.8 15.2 13.4 13.2 20.6 15.7 14.5 11.5 22.6 13.0 22.0 13.9 11.8 18.8 13.4 24.2 14.1 9.4 12.3 15.8 30.1 13.5 17.8 14.3 20.7 23.2 9.4 15.5 15.1 11.4 15.0 17.6 19.0 13.5 15.3 11.4 11.8 12.5 13.9 14.1 12.5 14.9 18.6 9.5 8.6 10.5 7.1 9.7 11.2 9.7 11.7 16.2 9.0 9.6 8.5 11.4 15.6 10.0 13.7 7.2 7.5 19.4 23.7 25.0 28.4 18.9 20.2 20.9 21.7 26.0 21.4 STRADB "ALS2CR2, CALS-21, ILPIP, ILPIPA, PAPK" ENSG00000082146 "STE20-related kinase adaptor beta" Q9C0K7 2 201387858-201480846 "Enzymes, Predicted intracellular proteins" "Cell cycle" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell line enhanced" "Detected in many" "LHCN-M2: 59.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA026549, HPA028520" Approved Supported Aggresome,Cytosol Cytosol Aggresome "HPA026549: AB_1844779, HPA028520: AB_10604100" "unprognostic (6.34e-2)" "unprognostic (2.48e-1)" "unprognostic (2.63e-1)" "unprognostic (3.56e-3)" "unprognostic (4.04e-2)" "unprognostic (7.64e-2)" "unprognostic (1.35e-1)" "unprognostic (1.58e-1)" "unprognostic (2.63e-3)" "unprognostic (2.65e-2)" "unprognostic (6.21e-2)" "unprognostic (2.74e-2)" "prognostic unfavourable (1.35e-4)" "unprognostic (1.08e-1)" "unprognostic (7.83e-2)" "prognostic favourable (4.45e-4)" "unprognostic (4.93e-2)" 13.8 28.6 13.8 7.9 11.7 32.7 9.2 8.8 13.5 6.4 13.7 16.9 4.9 18.8 10.3 9.5 8.9 5.7 7.9 15.2 15.3 11.5 35.2 50.5 7.2 10.1 15.8 11.0 7.8 9.1 3.9 14.1 11.6 12.7 7.1 15.9 10.1 7.1 7.7 48.3 4.4 21.3 7.4 21.0 7.3 4.7 7.8 9.4 8.3 9.7 7.8 7.7 6.2 6.2 24.1 10.4 9.7 8.6 16.3 10.4 9.6 3.9 6.8 11.8 15.1 19.3 24.5 8.3 8.0 13.9 11.1 16.8 8.9 3.8 0.0 5.2 12.6 4.0 11.4 7.5 20.2 4.6 9.3 4.7 3.2 19.7 14.6 5.6 5.4 20.7 6.9 14.2 12.8 8.3 10.1 1.7 59.9 2.1 5.1 9.8 15.9 7.0 7.0 4.6 2.9 9.4 3.2 1.9 9.7 5.5 4.2 23.4 2.2 10.7 8.0 6.8 5.2 8.6 6.1 6.6 11.7 1.8 11.5 2.5 6.4 3.4 8.0 9.7 6.0 8.6 5.4 16.7 8.0 8.6 10.4 24.1 10.4 10.3 1.6 16.3 7.5 4.6 9.5 9.6 13.8 11.7 8.8 13.5 15.3 11.5 15.8 11.0 12.7 9.4 TAOK1 "FLJ14314, KIAA1361, MAP3K16, MARKK, PSK2, TAO1" ENSG00000160551 "TAO kinase 1" Q7L7X3 17 29390464-29551904 "Enzymes, Predicted intracellular proteins" "Apoptosis, DNA damage, DNA repair" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA007669 Approved Approved Vesicles 13000 Vesicles "HPA007669: AB_1080201" "unprognostic (1.46e-1)" "unprognostic (7.15e-3)" "unprognostic (2.70e-2)" "unprognostic (1.52e-1)" "unprognostic (1.81e-2)" "unprognostic (4.85e-2)" "unprognostic (1.28e-2)" "unprognostic (4.31e-2)" "unprognostic (1.15e-1)" "unprognostic (6.91e-2)" "unprognostic (1.61e-1)" "unprognostic (1.36e-1)" "unprognostic (2.85e-2)" "unprognostic (5.53e-3)" "unprognostic (3.57e-1)" "unprognostic (1.66e-1)" "unprognostic (2.62e-1)" 17.2 11.5 19.1 11.9 25.0 12.7 13.3 20.1 24.4 15.8 11.9 22.2 7.9 7.1 14.9 10.8 12.7 11.0 11.6 15.3 18.7 15.5 13.6 10.6 13.2 11.1 30.0 17.6 13.5 9.3 31.7 13.7 14.3 21.8 12.0 10.7 10.9 11.1 13.3 15.0 13.8 9.8 17.7 21.0 13.0 10.8 14.3 23.5 11.7 17.7 6.0 11.2 14.5 17.1 2.4 4.8 5.5 2.1 1.4 3.0 0.9 13.6 24.3 19.2 8.2 14.3 18.1 8.1 12.9 13.8 11.9 12.5 13.1 4.8 8.5 12.7 21.0 10.7 17.5 8.9 21.4 17.6 12.9 13.5 14.1 7.0 10.4 14.9 12.5 11.9 11.5 17.5 18.0 16.2 13.8 7.7 15.5 9.1 11.7 5.5 8.1 6.2 10.9 27.1 5.9 11.2 19.7 10.6 13.0 22.2 20.8 13.4 15.0 13.8 23.5 18.2 14.8 15.9 18.0 7.1 15.3 9.8 13.3 9.4 16.4 1.7 1.9 1.5 2.0 2.1 1.6 1.6 2.0 2.4 1.7 2.4 3.0 2.2 5.5 1.4 1.9 4.8 1.2 0.9 19.1 25.0 20.1 22.7 18.7 15.5 30.0 17.6 21.8 23.5 TAOK2 "KIAA0881, MAP3K17, PSK, PSK1, TAO1, TAO2" ENSG00000149930 "TAO kinase 2" Q9UL54 16 29973641-29992261 "Enzymes, Predicted intracellular proteins, Predicted membrane proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA010650 Approved Supported Nucleoplasm,Nucleoli,Cytosol "Nucleoplasm, Cytosol" Nucleoli "HPA010650: AB_1080204" "unprognostic (7.30e-2)" "unprognostic (1.78e-1)" "prognostic unfavourable (2.51e-4)" "prognostic favourable (3.87e-5)" "unprognostic (8.46e-2)" "unprognostic (2.14e-3)" "unprognostic (6.08e-2)" "unprognostic (1.12e-3)" "unprognostic (1.01e-2)" "unprognostic (1.60e-1)" "prognostic favourable (4.78e-4)" "unprognostic (3.85e-3)" "prognostic favourable (3.66e-4)" "unprognostic (7.42e-3)" "unprognostic (3.17e-1)" "unprognostic (7.47e-2)" "unprognostic (1.37e-1)" 27.8 24.1 26.2 15.1 26.7 12.3 17.7 29.2 30.6 13.5 13.6 21.5 11.8 18.5 16.8 13.0 12.4 14.1 15.1 17.6 25.0 18.2 13.9 10.4 23.0 14.4 22.1 22.7 15.8 16.3 26.2 18.7 22.5 20.7 13.6 9.6 15.0 17.1 15.9 22.8 20.0 19.3 14.8 14.9 26.3 16.0 21.2 20.2 14.0 15.9 9.8 11.5 12.8 18.0 2.6 3.3 4.8 2.8 2.0 3.2 2.0 11.2 21.5 11.8 18.5 13.8 9.3 18.1 20.6 11.0 14.0 13.1 17.2 15.0 12.2 17.5 14.8 17.5 10.7 10.4 7.5 18.9 22.7 13.1 21.7 17.2 10.1 12.8 25.2 10.9 9.0 14.8 6.0 23.3 11.7 12.4 13.3 20.7 14.9 18.3 11.4 14.5 27.7 17.1 11.3 8.8 10.6 13.9 11.1 11.8 15.8 6.1 19.8 14.6 32.5 24.1 11.2 17.1 11.9 18.1 11.6 11.5 14.8 14.8 17.5 1.3 2.8 1.5 2.9 2.7 3.1 2.0 2.9 2.6 1.8 2.6 1.6 1.4 4.8 2.0 1.4 3.3 3.2 2.0 26.2 26.7 29.2 30.6 25.0 18.2 22.1 22.7 20.7 20.2 TAOK3 "DPK, JIK, MAP3K18" ENSG00000135090 "TAO kinase 3" Q9H2K8 12 118149801-118372945 "Enzymes, Predicted intracellular proteins" "DNA damage, DNA repair" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell line enhanced" "Detected in many" "HMC-1: 41.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA017160 Approved Uncertain Mitochondria Mitochondria "HPA017160: AB_1851994" "unprognostic (3.21e-1)" "unprognostic (1.31e-1)" "unprognostic (1.65e-1)" "unprognostic (3.74e-2)" "unprognostic (5.18e-2)" "unprognostic (2.09e-1)" "unprognostic (4.80e-1)" "unprognostic (5.86e-2)" "unprognostic (1.00e-1)" "unprognostic (7.38e-2)" "unprognostic (2.76e-2)" "unprognostic (8.23e-2)" "unprognostic (1.08e-2)" "unprognostic (2.08e-2)" "unprognostic (4.14e-3)" "unprognostic (2.56e-1)" "unprognostic (1.44e-1)" 14.6 16.2 31.9 24.1 31.0 30.8 14.6 44.3 33.5 11.6 21.2 17.2 10.3 23.1 15.2 11.4 16.0 9.8 16.9 15.1 27.8 31.7 14.0 15.3 19.4 26.3 25.7 20.8 17.5 10.9 20.2 23.6 11.9 20.7 25.6 21.3 12.0 13.6 14.6 18.5 17.0 31.6 15.3 23.7 24.2 20.9 8.9 28.6 28.3 18.1 9.9 26.9 18.5 18.3 20.9 22.4 38.2 37.8 36.4 27.8 17.1 8.2 5.7 4.3 3.7 10.5 12.8 4.9 8.6 9.8 5.0 6.6 2.9 12.8 25.2 2.8 11.5 7.4 3.7 7.7 7.9 9.1 3.2 29.7 2.9 3.7 12.3 30.4 41.9 8.7 9.3 15.9 23.3 16.1 17.2 3.0 9.2 5.8 16.0 20.0 1.6 3.0 9.4 5.8 2.6 4.7 14.3 0.8 4.2 8.0 3.6 11.0 7.4 22.8 24.9 8.7 1.5 8.1 7.4 2.9 2.8 19.9 12.3 21.0 11.6 38.2 17.0 37.6 27.8 23.3 26.2 20.9 21.2 24.1 22.4 19.3 18.8 24.5 37.7 36.4 37.8 20.9 19.3 17.1 31.9 31.0 44.3 33.5 27.8 31.7 25.7 20.8 20.7 28.6 TNIK KIAA0551 ENSG00000154310 "TRAF2 and NCK interacting kinase" Q9UKE5 3 171061339-171460408 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" "Neurogenesis, Wnt signaling pathway" "Kinase, Serine/threonine-protein kinase, Transferase" "Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 30.9" "Cell line enhanced" "Detected in many" "AF22: 19.6;HEL: 26.6;HMC-1: 30.3;HUVEC TERT2: 19.5;WM-115: 22.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 23 "basophil: 4.4;eosinophil: 10.5;gdT-cell: 4.2;MAIT T-cell: 5.2;memory CD4 T-cell: 5.0;memory CD8 T-cell: 3.7;naive CD4 T-cell: 6.7;naive CD8 T-cell: 3.8;NK-cell: 2.7;T-reg: 5.3" "Group enriched" "Detected in many" 29 "granulocytes: 10.5;NK-cells: 2.7;T-cells: 6.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA012128, HPA012297" Approved Supported Nucleoplasm,Cytosol 9100 Nucleoplasm Cytosol "HPA012128: AB_1858226, HPA012297: AB_1858225" "unprognostic (2.29e-1)" "unprognostic (1.12e-2)" "unprognostic (1.32e-1)" "unprognostic (5.90e-2)" "unprognostic (5.25e-2)" "unprognostic (9.23e-2)" "unprognostic (4.91e-2)" "unprognostic (2.41e-3)" "unprognostic (1.91e-1)" "unprognostic (7.81e-2)" "unprognostic (5.91e-2)" "unprognostic (1.96e-2)" "unprognostic (3.34e-3)" "unprognostic (2.41e-1)" "unprognostic (1.64e-1)" "unprognostic (2.13e-2)" "unprognostic (3.97e-2)" 2.2 5.4 29.0 7.4 30.9 4.9 3.6 21.1 26.1 1.9 10.9 12.2 4.1 25.8 4.3 2.1 5.6 4.3 7.1 11.2 30.9 14.8 5.6 4.6 11.3 7.9 11.4 18.3 2.6 5.2 0.7 9.0 3.1 13.6 5.6 9.5 3.5 2.9 7.3 23.2 1.6 25.6 6.0 14.5 5.8 9.2 10.7 21.1 3.7 7.1 2.2 6.9 6.4 2.6 0.2 0.0 10.5 0.1 2.7 6.7 1.1 0.3 0.5 19.6 2.0 0.3 0.0 4.6 4.1 1.1 3.2 2.2 17.5 7.3 0.0 1.4 3.7 6.0 2.8 1.1 3.5 0.1 4.3 26.6 1.5 0.0 9.4 5.2 30.3 2.8 2.9 1.9 0.4 19.5 9.6 0.0 0.5 0.4 1.6 6.7 8.0 7.6 0.0 5.0 7.0 6.3 0.0 0.9 1.0 2.5 0.2 4.3 8.8 1.3 0.2 0.0 3.4 8.9 3.0 0.0 0.0 0.0 0.9 5.9 22.7 4.4 0.1 10.5 4.2 0.0 5.2 0.0 5.0 3.7 0.0 0.2 6.7 3.8 0.1 2.7 0.1 0.0 5.3 1.1 29.0 30.9 21.1 22.2 30.9 14.8 11.4 18.3 13.6 21.1