Calcium release activated channel regulator 2A (gene: CRACR2A) displays a diverse expression pattern in the salivary gland.

Exploring protein expression in the salivary gland using multiplex immunohistochemistry (mIHC/IF) makes it possible to visualize complex staining patterns in the different structural components of the tissue. For the calcium channel-associated protein CRACR2A, staining (green) is localized to the cytoplasm of serous acini (cyan), but also to the apical part of the membrane of large ducts (red).

The spatial expression data from salivary gland is further supported by the single-cell RNA sequencing data for CRACR2A available in the Single Cell resource at the Human Protein Atlas showing enhanced expression in both glandular and ductal cell types of the salivary gland.

For more details about the mIHC/IF technique visit our method page.