Gene "Gene synonym" Ensembl "Gene description" Uniprot Chromosome Position "Protein class" "Biological process" "Molecular function" "Disease involvement" Evidence "HPA evidence" "UniProt evidence" "NeXtProt evidence" "MS evidence" "RNA tissue specificity" "RNA tissue distribution" "RNA tissue specificity score" "RNA tissue specific NX" "RNA cell line specificity" "RNA cell line distribution" "RNA cell line specificity score" "RNA cell line specific NX" "RNA cancer specificity" "RNA cancer distribution" "RNA cancer specificity score" "RNA cancer specific FPKM" "RNA brain regional specificity" "RNA brain regional distribution" "RNA brain regional specificity score" "RNA brain regional specific NX" "RNA blood cell specificity" "RNA blood cell distribution" "RNA blood cell specificity score" "RNA blood cell specific NX" "RNA blood lineage specificity" "RNA blood lineage distribution" "RNA blood lineage specificity score" "RNA blood lineage specific NX" "RNA mouse brain regional specificity" "RNA mouse brain regional distribution" "RNA mouse brain regional specificity score" "RNA mouse brain regional specific pTPM" "RNA pig brain regional specificity" "RNA pig brain regional distribution" "RNA pig brain regional specificity score" "RNA pig brain regional specific pTPM" Antibody "Reliability (IH)" "Reliability (Mouse Brain)" "Reliability (IF)" "Subcellular location" "Secretome location" "Blood concentration - Conc. blood IM [pg/L]" "Blood concentration - Conc. blood MS [pg/L]" "Subcellular main location" "Subcellular additional location" "Antibody RRID" "Pathology prognostics - Breast cancer" "Pathology prognostics - Cervical cancer" "Pathology prognostics - Colorectal cancer" "Pathology prognostics - Endometrial cancer" "Pathology prognostics - Glioma" "Pathology prognostics - Head and neck cancer" "Pathology prognostics - Liver cancer" "Pathology prognostics - Lung cancer" "Pathology prognostics - Melanoma" "Pathology prognostics - Ovarian cancer" "Pathology prognostics - Pancreatic cancer" "Pathology prognostics - Prostate cancer" "Pathology prognostics - Renal cancer" "Pathology prognostics - Stomach cancer" "Pathology prognostics - Testis cancer" "Pathology prognostics - Thyroid cancer" "Pathology prognostics - Urothelial cancer" "Tissue RNA - adipose tissue [NX]" "Tissue RNA - adrenal gland [NX]" "Tissue RNA - amygdala [NX]" "Tissue RNA - appendix [NX]" "Tissue RNA - basal ganglia [NX]" "Tissue RNA - bone marrow [NX]" "Tissue RNA - breast [NX]" "Tissue RNA - cerebellum [NX]" "Tissue RNA - cerebral cortex [NX]" "Tissue RNA - cervix, uterine [NX]" "Tissue RNA - colon [NX]" "Tissue RNA - corpus callosum [NX]" "Tissue RNA - ductus deferens [NX]" "Tissue RNA - duodenum [NX]" "Tissue RNA - endometrium 1 [NX]" "Tissue RNA - epididymis [NX]" "Tissue RNA - esophagus [NX]" "Tissue RNA - fallopian tube [NX]" "Tissue RNA - gallbladder [NX]" "Tissue RNA - heart muscle [NX]" "Tissue RNA - hippocampal formation [NX]" "Tissue RNA - hypothalamus [NX]" "Tissue RNA - kidney [NX]" "Tissue RNA - liver [NX]" "Tissue RNA - lung [NX]" "Tissue RNA - lymph node [NX]" "Tissue RNA - midbrain [NX]" "Tissue RNA - olfactory region [NX]" "Tissue RNA - ovary [NX]" "Tissue RNA - pancreas [NX]" "Tissue RNA - parathyroid gland [NX]" "Tissue RNA - pituitary gland [NX]" "Tissue RNA - placenta [NX]" "Tissue RNA - pons and medulla [NX]" "Tissue RNA - prostate [NX]" "Tissue RNA - rectum [NX]" "Tissue RNA - retina [NX]" "Tissue RNA - salivary gland [NX]" "Tissue RNA - seminal vesicle [NX]" "Tissue RNA - skeletal muscle [NX]" "Tissue RNA - skin 1 [NX]" "Tissue RNA - small intestine [NX]" "Tissue RNA - smooth muscle [NX]" "Tissue RNA - spinal cord [NX]" "Tissue RNA - spleen [NX]" "Tissue RNA - stomach 1 [NX]" "Tissue RNA - testis [NX]" "Tissue RNA - thalamus [NX]" "Tissue RNA - thymus [NX]" "Tissue RNA - thyroid gland [NX]" "Tissue RNA - tongue [NX]" "Tissue RNA - tonsil [NX]" "Tissue RNA - urinary bladder [NX]" "Tissue RNA - vagina [NX]" "Tissue RNA - B-cells [NX]" "Tissue RNA - dendritic cells [NX]" "Tissue RNA - granulocytes [NX]" "Tissue RNA - monocytes [NX]" "Tissue RNA - NK-cells [NX]" "Tissue RNA - T-cells [NX]" "Tissue RNA - total PBMC [NX]" "Cell RNA - A-431 [NX]" "Cell RNA - A549 [NX]" "Cell RNA - AF22 [NX]" "Cell RNA - AN3-CA [NX]" "Cell RNA - ASC diff [NX]" "Cell RNA - ASC TERT1 [NX]" "Cell RNA - BEWO [NX]" "Cell RNA - BJ [NX]" "Cell RNA - BJ hTERT+ [NX]" "Cell RNA - BJ hTERT+ SV40 Large T+ [NX]" "Cell RNA - BJ hTERT+ SV40 Large T+ RasG12V [NX]" "Cell RNA - CACO-2 [NX]" "Cell RNA - CAPAN-2 [NX]" "Cell RNA - Daudi [NX]" "Cell RNA - EFO-21 [NX]" "Cell RNA - fHDF/TERT166 [NX]" "Cell RNA - HaCaT [NX]" "Cell RNA - HAP1 [NX]" "Cell RNA - HBEC3-KT [NX]" "Cell RNA - HBF TERT88 [NX]" "Cell RNA - HDLM-2 [NX]" "Cell RNA - HEK 293 [NX]" "Cell RNA - HEL [NX]" "Cell RNA - HeLa [NX]" "Cell RNA - Hep G2 [NX]" "Cell RNA - HHSteC [NX]" "Cell RNA - HL-60 [NX]" "Cell RNA - HMC-1 [NX]" "Cell RNA - HSkMC [NX]" "Cell RNA - hTCEpi [NX]" "Cell RNA - hTEC/SVTERT24-B [NX]" "Cell RNA - hTERT-HME1 [NX]" "Cell RNA - HUVEC TERT2 [NX]" "Cell RNA - K-562 [NX]" "Cell RNA - Karpas-707 [NX]" "Cell RNA - LHCN-M2 [NX]" "Cell RNA - MCF7 [NX]" "Cell RNA - MOLT-4 [NX]" "Cell RNA - NB-4 [NX]" "Cell RNA - NTERA-2 [NX]" "Cell RNA - PC-3 [NX]" "Cell RNA - REH [NX]" "Cell RNA - RH-30 [NX]" "Cell RNA - RPMI-8226 [NX]" "Cell RNA - RPTEC TERT1 [NX]" "Cell RNA - RT4 [NX]" "Cell RNA - SCLC-21H [NX]" "Cell RNA - SH-SY5Y [NX]" "Cell RNA - SiHa [NX]" "Cell RNA - SK-BR-3 [NX]" "Cell RNA - SK-MEL-30 [NX]" "Cell RNA - T-47d [NX]" "Cell RNA - THP-1 [NX]" "Cell RNA - TIME [NX]" "Cell RNA - U-138 MG [NX]" "Cell RNA - U-2 OS [NX]" "Cell RNA - U-2197 [NX]" "Cell RNA - U-251 MG [NX]" "Cell RNA - U-266/70 [NX]" "Cell RNA - U-266/84 [NX]" "Cell RNA - U-698 [NX]" "Cell RNA - U-87 MG [NX]" "Cell RNA - U-937 [NX]" "Cell RNA - WM-115 [NX]" "Blood RNA - basophil [NX]" "Blood RNA - classical monocyte [NX]" "Blood RNA - eosinophil [NX]" "Blood RNA - gdT-cell [NX]" "Blood RNA - intermediate monocyte [NX]" "Blood RNA - MAIT T-cell [NX]" "Blood RNA - memory B-cell [NX]" "Blood RNA - memory CD4 T-cell [NX]" "Blood RNA - memory CD8 T-cell [NX]" "Blood RNA - myeloid DC [NX]" "Blood RNA - naive B-cell [NX]" "Blood RNA - naive CD4 T-cell [NX]" "Blood RNA - naive CD8 T-cell [NX]" "Blood RNA - neutrophil [NX]" "Blood RNA - NK-cell [NX]" "Blood RNA - non-classical monocyte [NX]" "Blood RNA - plasmacytoid DC [NX]" "Blood RNA - T-reg [NX]" "Blood RNA - total PBMC [NX]" "Brain RNA - amygdala [NX]" "Brain RNA - basal ganglia [NX]" "Brain RNA - cerebellum [NX]" "Brain RNA - cerebral cortex [NX]" "Brain RNA - hippocampal formation [NX]" "Brain RNA - hypothalamus [NX]" "Brain RNA - midbrain [NX]" "Brain RNA - olfactory region [NX]" "Brain RNA - pons and medulla [NX]" "Brain RNA - thalamus [NX]" ABTB2 "ABTB2A, BTBD22, DKFZP586C1619" ENSG00000166016 "Ankyrin repeat and BTB domain containing 2" Q8N961 11 34150988-34358008 "Predicted intracellular proteins" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "seminal vesicle: 31.6" "Cell line enhanced" "Detected in many" "SK-BR-3: 18.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 12 "eosinophil: 8.1;plasmacytoid DC: 2.8" "Group enriched" "Detected in many" 13 "dendritic cells: 2.8;granulocytes: 8.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA020065, HPA030699" Approved Enhanced Nucleoplasm Nucleoplasm "HPA020065: AB_1844459, HPA030699: " "unprognostic (3.00e-1)" "prognostic unfavourable (5.70e-5)" "unprognostic (2.61e-1)" "unprognostic (9.09e-2)" "unprognostic (3.17e-2)" "unprognostic (2.40e-2)" "unprognostic (1.34e-1)" "unprognostic (1.23e-2)" "unprognostic (2.04e-1)" "unprognostic (2.09e-1)" "unprognostic (1.24e-3)" "unprognostic (2.86e-1)" "prognostic favourable (3.51e-5)" "unprognostic (1.50e-1)" "unprognostic (1.42e-1)" "unprognostic (3.81e-2)" "unprognostic (6.58e-2)" 3.1 13.7 4.8 2.7 6.7 3.2 2.2 5.0 5.8 8.0 8.5 10.6 18.2 11.7 7.4 6.3 4.4 4.1 3.2 13.0 4.7 3.9 8.4 8.0 2.9 2.7 9.0 1.5 2.8 2.2 0.3 2.8 8.1 15.8 4.5 3.6 7.5 8.7 31.6 19.4 5.6 20.2 3.6 20.2 1.2 3.0 3.1 7.7 6.4 2.1 3.5 2.8 3.4 5.0 0.0 2.8 8.1 0.4 0.0 0.1 0.1 4.0 12.1 4.9 1.3 1.3 0.1 4.9 2.4 1.9 2.1 4.1 2.9 3.0 0.1 4.1 3.0 7.9 2.7 2.8 1.8 0.1 6.7 0.0 7.1 12.8 0.7 6.5 0.9 0.7 1.5 4.3 1.9 0.0 1.3 0.3 1.3 10.1 0.2 7.8 6.1 6.6 1.2 2.9 4.6 7.7 9.7 6.2 5.1 6.0 18.8 4.8 4.0 2.8 0.6 2.4 0.4 7.5 4.3 0.7 0.3 0.1 5.5 1.8 7.3 0.0 0.1 8.1 0.0 0.4 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.4 0.0 0.0 2.8 0.1 0.1 4.8 6.7 5.0 5.6 4.7 3.9 9.0 1.5 15.8 7.7 ACAA1 ENSG00000060971 "Acetyl-CoA acyltransferase 1" P09110 3 38103129-38137242 "Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins" "Fatty acid metabolism, Lipid metabolism" "Acyltransferase, Transferase" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 152.1" "Cell line enhanced" "Detected in all" "SK-BR-3: 85.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA006764, HPA007244" Enhanced Enhanced Peroxisomes 4300000 Peroxisomes "HPA006764: AB_1078085, HPA007244: AB_1078084" "prognostic favourable (3.00e-4)" "unprognostic (5.57e-2)" "unprognostic (4.54e-2)" "prognostic favourable (7.53e-4)" "unprognostic (2.63e-1)" "prognostic favourable (1.23e-4)" "unprognostic (9.35e-3)" "unprognostic (2.91e-2)" "unprognostic (8.11e-2)" "unprognostic (2.22e-1)" "unprognostic (2.24e-1)" "unprognostic (4.90e-1)" "prognostic favourable (6.99e-9)" "unprognostic (1.72e-1)" "unprognostic (1.99e-1)" "unprognostic (2.50e-2)" "unprognostic (1.65e-2)" 9.5 12.7 11.0 5.6 11.9 9.6 10.2 8.1 14.3 6.7 16.1 12.5 10.6 23.4 4.9 13.3 12.1 4.6 16.0 17.7 10.2 8.9 48.7 152.1 8.2 5.9 14.0 9.4 5.0 19.2 7.4 5.9 6.8 11.0 13.4 12.4 7.3 11.5 9.4 9.8 6.2 23.8 4.8 12.7 10.0 8.5 4.4 10.9 5.7 9.3 10.1 10.2 9.4 7.0 9.2 47.0 32.8 45.2 17.8 19.3 18.8 8.4 9.2 3.1 9.9 13.6 7.9 10.9 7.8 11.3 8.9 8.5 12.3 9.5 5.0 5.6 12.4 5.6 8.5 13.1 4.9 7.3 8.8 6.5 8.1 34.8 8.8 14.8 14.5 14.7 9.4 7.6 5.5 12.0 6.0 5.9 9.9 11.0 14.3 10.6 3.3 11.2 3.3 6.0 8.4 25.1 25.1 2.7 4.2 7.6 85.3 5.4 8.8 11.9 8.7 5.4 5.2 10.7 10.6 7.8 5.0 3.9 8.8 12.9 8.5 15.3 29.9 32.8 13.6 40.7 11.4 9.2 13.1 13.3 47.0 8.7 13.0 12.1 20.4 17.8 45.2 27.7 19.3 18.8 11.0 11.9 8.1 14.3 10.2 8.9 14.0 9.4 11.0 10.9 ACAA2 DSAEC ENSG00000167315 "Acetyl-CoA acyltransferase 2" P42765 18 49782167-49813960 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Fatty acid metabolism, Lipid metabolism" "Acyltransferase, Hydrolase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in all" 4 "liver: 245.7" "Low cell line specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA042303 Approved Supported Mitochondria 3200000 Mitochondria "HPA042303: AB_10794046" "unprognostic (7.94e-2)" "unprognostic (3.14e-2)" "unprognostic (2.20e-3)" "prognostic unfavourable (8.53e-4)" "unprognostic (2.92e-2)" "unprognostic (2.28e-2)" "unprognostic (7.63e-2)" "unprognostic (1.70e-1)" "unprognostic (7.97e-2)" "unprognostic (8.03e-3)" "unprognostic (1.72e-1)" "unprognostic (3.84e-1)" "prognostic favourable (1.36e-10)" "unprognostic (1.39e-1)" "unprognostic (2.24e-1)" "unprognostic (8.26e-3)" "unprognostic (3.41e-1)" 22.7 12.9 9.4 6.9 10.7 4.4 13.0 3.6 7.0 4.1 27.2 8.0 7.8 25.9 5.1 5.1 7.1 4.1 9.2 38.9 6.8 7.0 60.3 245.7 7.9 7.5 10.7 6.1 6.4 13.6 6.3 7.1 7.5 6.7 7.9 18.4 9.5 3.3 6.2 22.9 4.2 37.0 11.3 9.7 6.9 6.0 6.5 7.5 8.4 15.7 8.8 5.0 8.1 4.9 13.0 31.8 27.5 33.0 35.5 40.9 28.6 0.7 13.9 23.2 21.2 30.7 16.2 11.8 7.1 11.6 12.0 9.3 29.5 12.0 12.4 15.2 26.1 0.9 38.6 4.5 11.9 37.9 9.1 8.8 18.1 34.9 14.5 0.1 16.6 21.4 1.5 19.4 6.1 19.6 7.6 11.7 33.2 16.0 0.5 19.1 21.0 5.6 30.4 49.6 45.4 40.5 0.6 33.3 26.4 0.5 16.3 1.1 9.2 12.8 9.3 10.2 12.9 15.4 7.7 23.8 27.4 31.6 7.3 17.9 9.3 13.1 25.9 27.5 32.1 33.0 40.9 13.0 19.2 28.6 31.8 9.7 16.4 24.3 2.5 35.5 31.1 14.9 22.6 28.6 9.4 10.7 3.6 7.0 6.8 7.0 10.7 6.1 6.7 7.5 ACE "ACE1, CD143, DCP1" ENSG00000159640 "Angiotensin I converting enzyme" P12821 17 63477061-63498380 "Candidate cardiovascular disease genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 5 "intestine: 205.6" "Group enriched" "Detected in some" 4 "ASC TERT1: 35.9;HUVEC TERT2: 18.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in some" "Cell type enhanced" "Detected in some" "memory B-cell: 3.7" "Group enriched" "Detected in many" 23 "B-cells: 3.7;monocytes: 2.0;T-cells: 1.9" "CAB002426, CAB002921, HPA029298, HPA069790" Enhanced Approved Vesicles "Secreted to blood" 121920000 92000000 Vesicles "CAB002426: AB_442052, CAB002921: , HPA029298: AB_10960255, HPA069790: " "unprognostic (4.72e-2)" "unprognostic (4.16e-1)" "unprognostic (1.93e-3)" "unprognostic (6.06e-2)" "unprognostic (2.78e-1)" "unprognostic (1.35e-2)" "unprognostic (4.37e-1)" "unprognostic (1.54e-1)" "unprognostic (1.56e-1)" "unprognostic (1.25e-2)" "unprognostic (3.13e-2)" "unprognostic (2.38e-1)" "unprognostic (7.66e-2)" "unprognostic (9.07e-2)" "unprognostic (1.66e-1)" "unprognostic (1.08e-1)" "unprognostic (2.76e-2)" 6.8 2.0 0.5 2.4 4.2 0.0 2.9 0.5 1.1 5.3 83.2 0.7 37.7 46.4 4.5 5.1 1.7 1.5 4.4 4.7 0.6 0.7 2.6 1.4 16.3 2.2 0.4 0.7 1.4 3.0 3.6 3.6 3.6 0.8 3.4 1.4 1.7 2.5 20.1 3.6 1.3 205.6 2.4 0.6 1.4 1.9 32.6 1.3 0.5 6.9 3.1 2.2 1.7 1.6 3.7 0.1 0.0 2.0 0.0 1.9 0.4 0.0 0.0 0.0 0.0 1.5 35.9 0.4 1.3 2.6 0.0 0.0 0.5 3.1 0.7 1.0 6.1 0.0 1.7 0.0 0.0 0.0 0.7 3.4 0.0 0.0 0.8 0.0 0.0 2.4 0.0 0.0 0.0 18.3 3.0 0.0 0.0 0.6 0.0 0.7 0.2 0.3 0.1 0.2 0.5 0.0 0.0 4.5 3.2 0.0 0.0 0.0 1.6 0.2 0.0 0.1 0.1 0.3 0.0 0.0 0.0 0.0 0.5 0.0 0.2 0.0 0.0 0.0 0.4 0.6 0.9 3.7 1.9 1.4 0.1 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.4 0.5 4.2 0.5 1.1 0.6 0.7 0.4 0.7 0.8 1.3 ACE2 ENSG00000130234 "Angiotensin I converting enzyme 2" Q9BYF1 X 15561033-15602148 "Enzymes, FDA approved drug targets, Predicted membrane proteins, Predicted secreted proteins" "Host-virus interaction" "Carboxypeptidase, Host cell receptor for virus entry, Hydrolase, Metalloprotease, Protease, Receptor" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 5 "intestine: 122.0" "Cell line enhanced" "Detected in some" "BEWO: 2.4;HaCaT: 4.1;Hep G2: 2.4;NB-4: 2.2;RPMI-8226: 2.0;RT4: 2.4;SH-SY5Y: 2.8" "Cancer enhanced" "Detected in many" "renal cancer: 26.9" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in all" "Not detected" "Not detected" "HPA000288, CAB026174" Enhanced "Secreted to blood" 85000 "CAB026174: , HPA000288: AB_1078160" "unprognostic (1.40e-1)" "unprognostic (7.26e-2)" "unprognostic (2.76e-2)" "unprognostic (5.71e-2)" "unprognostic (2.51e-1)" "unprognostic (5.26e-2)" "prognostic favourable (4.21e-4)" "unprognostic (2.34e-2)" "unprognostic (6.74e-3)" "unprognostic (2.54e-3)" "unprognostic (1.00e-1)" "unprognostic (1.74e-1)" "prognostic favourable (2.12e-5)" "unprognostic (1.94e-1)" "unprognostic (9.62e-2)" "unprognostic (2.11e-1)" "unprognostic (7.10e-2)" 4.5 0.4 0.2 0.8 0.2 0.0 2.3 0.2 0.2 0.4 49.1 0.2 2.3 46.0 0.4 2.7 1.2 0.6 16.4 10.5 0.2 0.1 23.2 1.2 0.8 0.6 0.2 0.2 1.3 1.6 0.0 0.2 1.0 0.2 0.5 1.3 0.2 1.1 1.2 0.7 0.2 122.0 0.3 0.2 0.2 0.5 17.9 0.2 0.2 4.5 0.5 0.2 0.4 0.9 0.0 0.0 0.2 0.0 0.0 0.3 0.0 0.2 0.0 0.4 0.0 0.7 0.0 2.4 0.0 0.0 0.0 0.0 0.0 1.3 0.0 0.6 0.0 4.1 0.2 0.1 0.0 0.1 0.1 0.0 0.0 2.4 0.0 0.0 0.0 0.0 0.3 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 2.2 0.1 0.2 0.0 0.0 2.0 0.4 2.4 0.6 2.8 0.1 0.3 0.2 0.2 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.2 0.2 0.2 0.2 0.2 0.1 0.2 0.2 0.2 0.2 ACOX1 PALMCOX ENSG00000161533 "Acyl-CoA oxidase 1" Q15067 17 75941507-75979363 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" "Fatty acid metabolism, Lipid metabolism" Oxidoreductase "Disease mutation" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 95.6" "Cell line enhanced" "Detected in all" "BEWO: 34.6;RT4: 46.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in all" 5 "basophil: 22.9;neutrophil: 38.6" "Lineage enriched" "Detected in all" 7 "granulocytes: 38.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB021094, HPA021192, HPA021195, HPA028759" Approved Approved Nucleoli,Peroxisomes 160000 Peroxisomes Nucleoli "CAB021094: AB_10261667, HPA021192: AB_1844527, HPA021195: AB_1844528, HPA028759: AB_10601352" "unprognostic (7.47e-2)" "unprognostic (3.69e-1)" "unprognostic (1.25e-3)" "unprognostic (1.36e-1)" "unprognostic (7.49e-2)" "unprognostic (8.14e-2)" "unprognostic (3.75e-2)" "unprognostic (4.95e-2)" "unprognostic (1.61e-1)" "unprognostic (5.33e-2)" "unprognostic (1.25e-1)" "unprognostic (3.38e-2)" "prognostic favourable (5.25e-7)" "unprognostic (3.39e-1)" "unprognostic (2.41e-2)" "unprognostic (1.72e-1)" "unprognostic (4.46e-2)" 21.8 12.9 8.8 8.3 10.2 4.2 13.6 6.4 9.8 6.4 26.5 8.2 9.6 31.0 6.6 6.7 19.5 6.0 12.3 16.0 8.3 7.9 20.8 95.6 9.2 7.5 8.2 8.3 7.6 28.7 9.8 8.9 13.6 7.8 9.5 14.3 11.3 9.5 9.1 18.3 13.4 53.1 7.9 6.7 7.2 13.6 6.2 6.3 7.1 9.1 11.4 10.6 10.6 7.9 1.6 3.3 38.6 5.8 2.1 2.7 2.2 5.3 7.6 2.5 3.8 13.0 5.5 34.6 3.9 3.9 4.7 5.4 5.3 8.8 3.1 4.2 6.6 3.2 10.5 4.1 7.4 2.8 3.1 4.0 4.3 17.3 7.1 3.4 2.6 9.1 3.2 5.3 3.5 11.7 4.0 3.0 5.2 15.7 7.4 2.5 1.8 6.5 4.1 7.6 3.6 8.0 46.6 3.0 4.5 11.1 17.5 3.7 10.7 3.8 7.8 6.5 4.8 5.3 3.7 5.0 3.4 1.2 3.8 3.1 3.8 22.9 5.8 1.6 2.1 4.5 2.7 1.6 2.0 2.7 3.3 1.6 2.4 2.3 38.6 2.1 2.8 2.9 2.6 2.2 8.8 10.2 6.4 9.8 8.3 7.9 8.2 8.3 7.8 6.3 ACOX3 ENSG00000087008 "Acyl-CoA oxidase 3, pristanoyl" O15254 4 8366282-8440723 "Enzymes, Predicted intracellular proteins" "Fatty acid metabolism, Lipid metabolism" Oxidoreductase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA035840, HPA035841" Uncertain Approved Peroxisomes Peroxisomes "HPA035840: AB_10696514, HPA035841: AB_10671940" "unprognostic (3.07e-2)" "unprognostic (5.51e-2)" "unprognostic (1.12e-1)" "prognostic favourable (2.16e-4)" "unprognostic (5.52e-2)" "unprognostic (1.81e-3)" "unprognostic (2.21e-1)" "unprognostic (3.37e-2)" "unprognostic (2.27e-1)" "unprognostic (4.43e-2)" "unprognostic (4.81e-1)" "unprognostic (1.39e-1)" "unprognostic (1.46e-2)" "unprognostic (3.58e-2)" "unprognostic (2.84e-1)" "unprognostic (1.69e-1)" "unprognostic (2.65e-1)" 9.6 12.0 9.9 7.4 10.9 5.0 15.5 11.7 12.8 12.2 9.9 11.5 11.2 10.8 10.7 12.3 32.0 9.2 7.4 20.6 9.0 6.7 8.3 18.0 8.9 7.4 10.3 8.4 9.8 15.4 10.0 14.8 28.9 10.2 13.4 8.0 12.0 19.1 11.2 8.2 14.8 10.5 18.6 7.2 7.6 12.7 5.0 11.6 9.0 11.5 7.4 14.2 14.8 16.0 4.6 16.8 2.6 12.0 7.3 8.0 6.9 6.3 6.9 7.8 10.4 8.4 14.3 12.8 8.1 11.1 13.8 12.1 3.4 8.5 8.5 8.8 16.4 3.9 3.4 10.5 10.8 2.9 3.3 3.7 5.8 10.5 13.9 7.5 7.0 14.4 9.0 12.3 4.8 16.2 4.9 7.9 11.8 5.8 8.0 11.1 4.4 12.0 8.4 12.8 10.2 8.5 8.9 3.8 8.8 10.3 5.3 5.3 5.3 10.7 15.7 13.7 4.5 5.5 8.4 5.9 3.9 3.8 17.4 9.5 8.6 0.0 10.6 2.6 5.2 12.0 5.4 4.6 6.1 6.6 14.0 4.5 5.6 5.8 2.5 7.3 10.6 16.8 8.0 6.9 9.9 10.9 11.7 12.8 9.0 6.7 10.3 8.4 10.2 11.6 ADH1A ADH1 ENSG00000187758 "Alcohol dehydrogenase 1A (class I), alpha polypeptide" P07327 4 99276367-99291028 "Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins" Oxidoreductase "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 322 "liver: 250.3" "Cell line enriched" "Detected in some" 5 "ASC diff: 10.9" "Cancer enriched" "Detected in some" 251 "liver cancer: 165.9" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "CAB009562, HPA047814, HPA060902" Enhanced Approved "Plasma membrane,Cytosol" 12000000 "Plasma membrane, Cytosol" "CAB009562: AB_2257984, HPA047814: , HPA060902: " "unprognostic (5.89e-2)" "unprognostic (6.16e-2)" "unprognostic (1.20e-1)" "unprognostic (2.07e-1)" "unprognostic (4.40e-1)" "prognostic favourable (2.38e-4)" "unprognostic (2.78e-3)" "unprognostic (4.25e-1)" "unprognostic (4.79e-3)" "unprognostic (6.21e-2)" "unprognostic (9.36e-2)" "unprognostic (3.25e-2)" "unprognostic (1.40e-1)" "unprognostic (2.86e-2)" 0.4 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.7 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 250.3 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.3 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 10.9 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.1 0.0 2.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 1.7 0.0 0.0 0.0 0.1 0.0 1.3 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.9 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 ADH1B ADH2 ENSG00000196616 "Alcohol dehydrogenase 1B (class I), beta polypeptide" P00325 4 99304964-99352760 "Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins" Oxidoreductase "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 5 "adipose tissue: 253.5;liver: 466.3" "Cell line enriched" "Detected in some" 7 "ASC diff: 385.0" "Cancer enriched" "Detected in many" 31 "liver cancer: 223.1" "Group enriched" "Detected in some" 5 "midbrain: 2.3;pons and medulla: 1.6" "Low cell type specificity" "Detected in single" "Low lineage specificity" "Detected in single" "HPA047814, HPA060902" Supported Approved "Plasma membrane,Cytosol" 16000000 "Plasma membrane, Cytosol" "HPA047814: , HPA060902: " "unprognostic (5.13e-2)" "unprognostic (9.80e-3)" "unprognostic (6.59e-2)" "unprognostic (5.56e-2)" "unprognostic (9.49e-2)" "unprognostic (5.53e-2)" "unprognostic (1.54e-3)" "unprognostic (1.04e-2)" "unprognostic (6.51e-2)" "unprognostic (2.73e-2)" "unprognostic (7.47e-3)" "unprognostic (7.79e-2)" "prognostic unfavourable (7.87e-4)" "unprognostic (4.60e-3)" "unprognostic (2.33e-1)" "unprognostic (2.58e-1)" "unprognostic (1.60e-2)" 253.5 12.3 0.2 21.8 0.0 0.4 78.7 0.2 0.4 18.3 60.0 0.4 5.7 3.5 12.8 14.4 33.5 22.3 31.9 24.2 0.3 0.0 9.2 466.3 43.8 17.5 2.3 0.1 18.0 8.7 0.8 5.3 0.9 1.6 30.7 10.1 2.3 11.2 3.9 20.5 11.9 25.4 30.8 2.4 5.9 10.9 18.0 0.2 0.2 16.1 9.7 2.0 42.3 76.0 0.6 0.2 1.2 0.3 0.8 0.4 0.0 0.0 0.0 0.0 0.0 385.0 56.5 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.5 0.1 0.0 12.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.3 0.3 0.2 0.1 0.1 0.2 0.4 0.1 0.0 0.6 0.3 0.4 1.2 0.8 0.1 0.2 0.1 0.0 0.2 0.0 0.2 0.0 0.3 0.0 2.3 0.1 1.6 0.2 ADH1C ADH3 ENSG00000248144 "Alcohol dehydrogenase 1C (class I), gamma polypeptide" P00326 4 99336492-99353027 "Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins" Oxidoreductase "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 4 "intestine: 47.1;liver: 149.4;stomach 1: 43.1" "Group enriched" "Detected in some" 4 "ASC TERT1: 5.1;HSkMC: 15.1" "Cancer enriched" "Detected in many" 7 "liver cancer: 238.2" "Not detected" "Not detected" "Not detected" "Not detected" "HPA047814, HPA060902" Supported Supported "Plasma membrane,Cytosol" 9700000 "Plasma membrane, Cytosol" "HPA047814: , HPA060902: " "unprognostic (3.98e-2)" "unprognostic (9.88e-3)" "unprognostic (7.04e-2)" "unprognostic (1.90e-1)" "unprognostic (5.14e-1)" "unprognostic (1.57e-1)" "prognostic favourable (4.55e-4)" "prognostic favourable (2.99e-4)" "unprognostic (8.25e-2)" "unprognostic (8.89e-3)" "unprognostic (7.95e-2)" "unprognostic (2.04e-1)" "unprognostic (1.12e-1)" "unprognostic (1.21e-1)" "unprognostic (1.53e-1)" "unprognostic (1.70e-1)" "unprognostic (9.37e-2)" 4.7 0.0 0.0 18.5 0.0 0.0 1.1 0.0 0.0 1.1 37.9 0.0 1.1 43.4 0.3 1.2 1.7 0.0 12.0 2.0 0.0 8.3 149.4 1.1 0.0 0.2 0.0 1.1 11.4 0.0 0.0 0.0 0.0 2.5 13.6 0.0 1.1 0.8 6.0 0.0 47.1 0.9 0.5 0.0 43.1 1.6 0.0 0.0 0.5 2.0 0.2 1.3 0.7 0.2 0.2 0.3 0.1 0.1 0.3 0.1 0.0 2.2 0.0 0.1 1.7 5.1 1.1 0.0 0.6 0.1 0.0 0.0 0.0 0.2 0.2 0.2 0.1 0.0 0.0 0.0 0.1 0.0 0.5 0.3 0.1 0.5 1.4 0.3 15.1 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.4 0.9 0.4 0.1 0.1 0.9 2.1 0.9 0.0 0.4 1.6 0.7 0.8 0.0 0.2 0.0 0.1 0.0 0.6 0.3 0.2 0.1 0.0 0.3 0.0 0.8 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.1 0.0 0.3 0.0 0.2 0.0 0.1 0.3 0.1 0.0 0.2 0.0 0.1 ADH4 ADH-2 ENSG00000198099 "Alcohol dehydrogenase 4 (class II), pi polypeptide" P08319 4 99123657-99157792 "Enzymes, Plasma proteins, Predicted intracellular proteins" Oxidoreductase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 31 "liver: 345.2" "Cell line enriched" "Detected in some" 11 "Hep G2: 21.9" "Cancer enriched" "Detected in some" 60 "liver cancer: 230.7" "Not detected" "Not detected" "Low cell type specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Not detected" "Not detected" "Low region specificity" "Detected in many" HPA020525 Enhanced Uncertain Nucleoplasm,Cytosol 5300000 "Nucleoplasm, Cytosol" "HPA020525: AB_1844609" "unprognostic (2.75e-1)" "unprognostic (1.69e-2)" "unprognostic (1.85e-2)" "unprognostic (5.54e-3)" "unprognostic (2.14e-2)" "unprognostic (1.33e-2)" "prognostic favourable (7.08e-6)" "unprognostic (1.49e-1)" "unprognostic (1.39e-2)" "unprognostic (6.91e-2)" "unprognostic (1.88e-1)" "unprognostic (2.34e-2)" "unprognostic (7.16e-3)" "unprognostic (2.20e-1)" "unprognostic (5.89e-3)" 0.3 0.1 0.0 0.1 0.0 0.0 0.6 0.0 0.1 0.2 3.6 0.0 0.1 11.0 0.0 0.1 0.7 0.0 0.0 0.1 0.0 0.0 0.2 345.2 0.1 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.4 0.1 0.4 0.1 4.5 0.0 0.0 0.1 0.1 0.1 0.0 0.0 0.2 0.8 0.1 0.1 0.5 1.2 0.7 2.8 0.5 0.4 0.9 0.1 0.3 0.3 0.2 0.3 0.4 0.1 0.2 0.2 0.0 0.0 0.0 0.2 0.2 0.5 0.3 0.0 0.3 0.0 0.2 0.4 0.2 0.1 0.5 0.8 21.9 0.1 1.8 0.5 0.3 0.0 0.2 0.2 0.1 0.4 1.0 0.1 0.3 0.3 0.6 0.3 0.2 0.2 1.8 0.5 0.2 0.4 0.2 0.3 2.0 0.3 0.0 0.5 0.0 0.4 0.5 0.2 0.4 0.1 0.6 0.4 0.7 0.1 0.7 0.1 2.8 0.4 0.5 0.9 0.5 0.8 0.4 0.5 0.5 0.1 1.2 0.8 0.8 1.0 0.4 0.5 0.7 0.3 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.1 0.0 ADH5 "ADH-3, ADHX, FDH, GSNOR" ENSG00000197894 "Alcohol dehydrogenase 5 (class III), chi polypeptide" P11766 4 99070978-99088801 "Enzymes, Plasma proteins, Predicted intracellular proteins" Oxidoreductase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA044578, HPA061919" Approved 6800000 "HPA044578: , HPA061919: AB_2684638" "unprognostic (1.05e-1)" "unprognostic (1.63e-2)" "unprognostic (1.14e-3)" "prognostic favourable (9.90e-5)" "unprognostic (2.63e-1)" "unprognostic (1.58e-2)" "unprognostic (1.11e-1)" "unprognostic (9.48e-2)" "prognostic unfavourable (3.54e-4)" "unprognostic (1.47e-1)" "unprognostic (1.02e-2)" "unprognostic (1.22e-1)" "prognostic favourable (4.58e-10)" "unprognostic (1.79e-3)" "unprognostic (9.05e-2)" "unprognostic (1.15e-2)" "unprognostic (1.13e-1)" 35.6 19.8 17.3 18.5 18.5 6.3 28.6 11.2 22.3 34.1 39.4 19.8 17.0 24.9 53.8 40.3 43.5 28.6 20.8 31.9 13.7 16.6 46.6 69.7 19.9 15.3 15.7 16.1 39.1 12.8 10.5 15.1 19.9 18.6 45.0 27.7 28.7 17.3 35.9 20.7 13.8 28.5 43.6 13.5 20.5 27.0 27.2 10.0 35.2 30.4 18.4 18.6 60.0 22.0 13.9 12.5 18.2 11.1 26.2 25.3 17.0 15.7 12.9 38.1 21.4 69.2 64.4 22.9 26.2 46.3 28.5 24.9 14.7 18.7 18.2 15.3 37.8 13.5 26.2 36.4 27.5 13.1 11.0 12.6 17.5 57.9 67.1 22.0 10.3 57.9 28.3 21.3 16.9 21.9 23.3 10.4 37.5 17.9 29.6 19.8 30.6 15.5 21.7 21.3 9.6 45.0 18.4 14.6 19.1 15.8 18.8 28.6 15.2 15.5 16.4 26.0 16.5 16.9 18.0 11.0 13.6 25.3 26.7 14.6 26.3 9.8 11.1 18.2 18.4 9.8 16.7 13.9 20.3 17.1 12.5 13.1 19.9 18.3 1.6 26.2 7.1 10.8 25.3 17.0 17.3 18.5 11.2 22.3 13.7 16.6 15.7 16.1 18.6 10.0 ADH6 ADH-5 ENSG00000172955 "Alcohol dehydrogenase 6 (class V)" P28332 4 99202638-99219537 "Enzymes, Predicted intracellular proteins" Oxidoreductase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 5 "liver: 123.3" "Cell line enriched" "Detected in some" 5 "Hep G2: 30.5" "Cancer enriched" "Detected in many" 18 "liver cancer: 46.9" "Not detected" "Not detected" "Cell type enhanced" "Detected in single" "neutrophil: 1.3" "Low lineage specificity" "Detected in single" "Low region specificity" "Detected in some" "HPA067946, HPA069081" Enhanced 480000 "HPA067946: AB_2732776, HPA069081: AB_2732127" "unprognostic (1.38e-2)" "unprognostic (1.83e-2)" "unprognostic (5.82e-2)" "unprognostic (1.49e-3)" "unprognostic (8.49e-2)" "unprognostic (1.08e-1)" "unprognostic (5.11e-3)" "unprognostic (2.40e-1)" "unprognostic (3.60e-2)" "unprognostic (1.35e-1)" "unprognostic (9.72e-3)" "unprognostic (1.67e-1)" "unprognostic (3.66e-3)" "unprognostic (1.35e-1)" "unprognostic (2.43e-1)" "unprognostic (8.74e-3)" "unprognostic (3.86e-3)" 0.1 0.1 0.1 1.1 0.1 0.0 0.1 0.1 0.1 0.1 6.0 0.0 0.0 7.2 0.1 0.2 0.2 1.5 5.6 0.1 0.1 0.1 10.6 123.3 0.1 0.0 0.1 0.0 0.1 0.2 0.0 0.1 0.0 0.1 0.1 1.4 0.0 0.1 0.0 0.1 0.6 23.7 0.2 0.1 0.1 0.1 0.1 0.0 0.0 0.1 0.1 0.0 0.1 0.1 0.5 0.0 1.3 0.1 0.2 0.2 0.3 0.0 0.4 0.1 0.1 0.0 0.0 0.0 0.2 0.0 0.0 0.0 1.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 30.5 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.2 0.1 6.4 0.1 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.1 0.0 0.1 0.1 0.0 0.1 0.0 0.0 0.0 0.2 0.0 0.1 0.5 0.2 0.0 0.0 0.3 0.1 0.2 1.3 0.2 0.1 0.0 0.1 0.3 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.0 0.1 0.0 ADH7 ADH-4 ENSG00000196344 "Alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide" P40394 4 99412261-99435737 "Enzymes, Predicted intracellular proteins" Oxidoreductase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 6 "esophagus: 75.0;lymphoid tissue: 30.7;tongue: 68.7" "Group enriched" "Detected in some" 7 "ASC TERT1: 3.9;HaCaT: 4.4" "Group enriched" "Detected in some" 17 "cervical cancer: 18.4;head and neck cancer: 18.9;lung cancer: 22.4;urothelial cancer: 5.3" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA039695 Enhanced Supported "Plasma membrane,Cytosol" "Plasma membrane, Cytosol" "HPA039695: AB_10795681" "unprognostic (1.02e-2)" "unprognostic (8.64e-2)" "unprognostic (4.86e-2)" "unprognostic (5.66e-3)" "unprognostic (4.50e-2)" "unprognostic (1.66e-1)" "unprognostic (2.02e-1)" "unprognostic (1.88e-2)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 75.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 8.7 0.0 0.0 0.2 0.0 0.1 0.0 0.0 9.4 0.0 0.0 0.1 0.0 68.7 30.7 0.1 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 3.9 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 4.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 ADHFE1 "ADHFe1, FLJ32430" ENSG00000147576 "Alcohol dehydrogenase, iron containing 1" Q8IWW8 8 66430185-66471601 "Enzymes, Predicted intracellular proteins" Oxidoreductase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 44.5" "Cell line enhanced" "Detected in some" "ASC diff: 4.6;HHSteC: 3.0;HSkMC: 2.7;RPTEC TERT1: 4.5" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA023062 Enhanced Approved Vesicles Vesicles "HPA023062: AB_1844611" "prognostic favourable (5.76e-5)" "unprognostic (8.69e-2)" "unprognostic (6.71e-2)" "unprognostic (2.70e-1)" "unprognostic (1.14e-1)" "unprognostic (1.22e-1)" "prognostic favourable (9.90e-5)" "unprognostic (7.76e-3)" "unprognostic (2.88e-1)" "unprognostic (1.32e-1)" "unprognostic (1.59e-1)" "unprognostic (9.43e-2)" "prognostic favourable (4.55e-5)" "unprognostic (1.37e-2)" "unprognostic (2.06e-1)" "unprognostic (4.66e-2)" "unprognostic (5.94e-3)" 12.5 3.2 10.3 2.2 9.7 1.8 4.3 2.2 10.7 5.9 3.8 10.9 4.8 2.7 4.2 8.6 3.1 5.9 5.0 34.6 6.9 5.4 11.8 44.5 3.6 2.3 8.6 7.5 5.2 8.3 11.6 9.8 3.7 6.9 7.3 3.1 10.7 6.6 10.5 35.7 2.4 2.4 6.9 4.8 2.8 8.6 3.2 7.3 0.0 4.5 12.9 2.5 6.2 1.9 1.3 0.4 3.4 1.1 2.2 2.6 0.6 0.0 0.0 0.0 0.0 4.6 0.0 0.0 0.5 0.4 0.3 0.0 0.0 1.7 0.0 0.0 0.7 0.3 0.0 0.0 0.0 1.7 0.0 0.0 0.6 0.0 3.0 0.0 0.2 2.7 0.0 0.0 1.3 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 4.5 0.0 0.2 0.9 0.0 0.5 1.2 2.0 0.0 0.0 0.3 0.2 0.0 0.0 1.2 0.1 0.1 0.8 0.0 0.3 3.4 1.1 0.0 2.6 0.0 2.4 1.3 0.5 2.2 0.4 0.8 0.7 2.2 0.1 2.2 0.0 0.3 0.0 0.6 10.3 9.7 2.2 7.8 6.9 5.4 8.6 7.5 6.9 7.3 ALDH1A3 "ALDH6, RALDH3" ENSG00000184254 "Aldehyde dehydrogenase 1 family member A3" P47895 15 100877714-100916626 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" Oxidoreductase "Disease mutation, Microphthalmia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell line enhanced" "Detected in many" "A-431: 42.0;HaCaT: 52.3;HBEC3-KT: 129.5;U-2197: 74.4;U-87 MG: 59.2;WM-115: 61.1" "Group enriched" "Detected in many" 7 "melanoma: 16.8;prostate cancer: 80.5" "Low region specificity" "Detected in many" "Group enriched" "Detected in some" 4 "basophil: 1.0;eosinophil: 2.1;plasmacytoid DC: 1.5" "Group enriched" "Detected in many" 5 "dendritic cells: 1.5;granulocytes: 2.1" "Low region specificity" "Detected in many" "Low region specificity" "Detected in some" "HPA046271, HPA064749" Enhanced Supported Nucleoplasm,Cytosol Nucleoplasm Cytosol "HPA046271: AB_10965992, HPA064749: " "unprognostic (6.87e-2)" "unprognostic (2.23e-1)" "unprognostic (6.20e-3)" "unprognostic (1.21e-3)" "unprognostic (1.76e-2)" "unprognostic (1.14e-1)" "unprognostic (6.28e-2)" "unprognostic (5.46e-2)" "unprognostic (9.62e-2)" "unprognostic (4.53e-2)" "unprognostic (3.64e-2)" "unprognostic (2.56e-1)" "unprognostic (1.25e-2)" "unprognostic (2.61e-2)" "unprognostic (2.12e-1)" "unprognostic (7.34e-2)" "unprognostic (6.07e-3)" 30.3 5.7 2.3 14.9 1.6 0.0 11.1 4.1 2.6 14.2 11.5 1.6 10.5 5.2 5.9 37.9 10.5 11.5 15.0 6.1 2.1 2.0 3.7 1.7 4.2 5.5 2.6 1.7 9.0 7.4 3.2 13.2 5.1 3.9 51.9 3.2 49.9 41.5 19.2 6.1 1.7 15.6 14.2 6.4 1.5 5.3 15.9 0.7 0.6 0.9 15.2 18.9 18.0 9.8 0.3 1.5 2.1 0.2 0.0 0.0 0.1 42.0 5.6 0.0 0.0 9.3 4.1 0.1 0.3 0.3 0.2 0.1 0.1 33.7 0.3 0.5 11.3 52.3 1.0 129.5 0.8 0.0 0.2 0.2 2.3 0.0 3.1 0.1 0.2 2.9 3.6 2.9 0.5 0.4 0.0 0.2 0.2 0.4 0.0 0.2 1.1 34.2 0.0 0.5 0.2 0.0 35.3 0.0 3.0 13.1 11.5 3.9 1.1 0.3 6.6 0.0 0.1 74.4 1.6 0.0 0.3 0.2 59.2 0.0 61.1 1.0 0.2 2.1 0.0 0.0 0.0 0.3 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.1 1.5 0.0 0.1 2.3 1.6 4.1 2.6 2.1 2.0 2.6 1.7 3.9 0.7 ALDH3A1 ALDH3 ENSG00000108602 "Aldehyde dehydrogenase 3 family member A1" P30838 17 19737984-19748943 "Enzymes, Predicted intracellular proteins" Oxidoreductase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "esophagus: 88.2;lymphoid tissue: 70.3;stomach 1: 49.9;tongue: 106.6" "Cell line enriched" "Detected in some" 20 "A549: 321.7" "Low cancer specificity" "Detected in many" "Region enhanced" "Detected in single" "pons and medulla: 1.8" "Cell type enhanced" "Detected in some" "NK-cell: 2.4" "Low lineage specificity" "Detected in many" "Not detected" "Not detected" "Not detected" "Not detected" "CAB045957, HPA051150, HPA063783" Enhanced Supported "Nucleoplasm,Vesicles,Plasma membrane,Cytosol" "Plasma membrane, Cytosol" "Nucleoplasm, Vesicles" "CAB045957: AB_11127164, HPA051150: , HPA063783: " "unprognostic (3.11e-5)" "unprognostic (1.20e-2)" "unprognostic (1.08e-1)" "unprognostic (7.04e-3)" "unprognostic (4.36e-3)" "prognostic favourable (7.55e-5)" "unprognostic (3.12e-1)" "unprognostic (3.84e-1)" "unprognostic (2.10e-1)" "unprognostic (1.67e-1)" "unprognostic (2.69e-3)" "unprognostic (5.54e-2)" "unprognostic (1.72e-1)" "unprognostic (3.84e-2)" "unprognostic (1.83e-1)" "unprognostic (2.88e-2)" "unprognostic (7.23e-2)" 0.7 0.1 0.2 0.8 0.4 0.0 0.5 0.2 0.3 1.3 0.9 0.8 0.3 1.3 0.2 0.4 88.2 1.2 3.8 0.2 0.4 0.0 0.4 0.4 26.0 0.2 0.2 0.3 0.6 0.2 0.0 0.3 0.2 1.8 0.5 0.6 0.5 26.7 0.3 0.4 16.2 0.6 0.3 0.3 0.3 49.9 0.3 0.2 0.2 0.2 106.6 70.3 1.6 3.9 1.1 0.3 0.0 0.0 2.4 0.7 0.1 0.0 321.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 16.1 0.0 0.1 0.0 1.9 0.0 0.8 0.0 0.0 0.0 0.0 8.1 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 5.7 0.0 0.0 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 1.1 0.0 0.0 0.3 1.1 0.0 0.7 0.0 2.4 0.0 0.0 0.0 0.1 0.2 0.4 0.2 0.3 0.4 0.0 0.2 0.3 1.8 0.2 ALDH3B1 ALDH7 ENSG00000006534 "Aldehyde dehydrogenase 3 family member B1" P43353 11 68008578-68029282 "Enzymes, Predicted intracellular proteins" Oxidoreductase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "blood: 39.8" "Cell line enhanced" "Detected in many" "A549: 44.5;CAPAN-2: 45.9;U-87 MG: 27.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Cell type enhanced" "Detected in many" "eosinophil: 39.8" "Group enriched" "Detected in many" 10 "dendritic cells: 17.6;granulocytes: 39.8;monocytes: 32.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" HPA038525 Uncertain "HPA038525: " "unprognostic (3.50e-1)" "unprognostic (4.22e-1)" "prognostic unfavourable (1.18e-4)" "unprognostic (1.56e-2)" "unprognostic (9.66e-3)" "unprognostic (9.73e-2)" "unprognostic (7.93e-3)" "unprognostic (2.62e-1)" "unprognostic (2.01e-1)" "unprognostic (1.06e-1)" "prognostic unfavourable (6.07e-4)" "unprognostic (8.27e-2)" "unprognostic (6.49e-3)" "unprognostic (1.00e-1)" "unprognostic (2.75e-2)" "unprognostic (6.69e-3)" "unprognostic (1.06e-1)" 9.1 9.8 1.8 5.0 2.5 21.4 2.4 1.3 2.3 6.2 7.8 4.2 1.1 11.8 4.0 7.0 4.0 21.0 13.7 3.1 2.6 2.4 9.3 5.1 28.5 14.3 4.3 1.4 6.6 12.9 0.0 3.8 13.4 3.8 4.6 3.1 7.8 5.7 2.0 2.0 1.8 21.4 4.2 5.6 11.7 10.4 2.9 1.9 0.7 1.7 1.5 3.3 7.6 3.8 0.1 17.6 39.8 32.9 2.9 0.1 9.8 3.2 44.5 0.3 0.9 3.0 9.6 8.1 4.5 7.5 3.3 1.6 1.6 45.9 0.2 8.1 10.5 3.8 0.1 0.6 0.8 0.1 0.3 0.4 17.9 3.9 18.9 2.6 0.1 6.9 2.0 1.6 4.4 0.1 0.1 8.1 5.2 2.7 0.2 2.5 0.3 2.7 1.0 1.7 24.5 5.3 0.4 0.5 0.2 10.5 8.8 4.4 10.2 5.8 5.0 4.7 6.7 22.9 1.5 0.1 0.8 0.0 27.1 7.3 2.1 11.8 23.0 39.8 0.0 32.9 0.1 0.1 0.0 0.0 17.6 0.1 0.0 0.0 6.9 2.9 29.1 1.8 0.0 9.8 1.8 2.5 1.3 2.3 2.6 2.4 4.3 1.4 3.8 1.9 ALDH3B2 ALDH8 ENSG00000132746 "Aldehyde dehydrogenase 3 family member B2" P48448 11 67662162-67681200 "Enzymes, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins" Oxidoreductase "FDA approved drug targets" "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Tissue enhanced" "Detected in many" "breast: 28.1;esophagus: 48.2;lymphoid tissue: 34.2;skin 1: 38.7" "Group enriched" "Detected in some" 5 "MCF7: 30.9;SK-BR-3: 32.0" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Cell type enhanced" "Detected in single" "naive B-cell: 1.0" "Low lineage specificity" "Detected in single" "Not detected" "Not detected" HPA045132 Approved "HPA045132: AB_10795993" "unprognostic (2.25e-1)" "unprognostic (2.41e-1)" "unprognostic (1.65e-1)" "unprognostic (8.65e-2)" "unprognostic (2.13e-1)" "unprognostic (6.09e-2)" "unprognostic (3.12e-2)" "unprognostic (6.32e-2)" "unprognostic (1.48e-1)" "unprognostic (5.56e-2)" "unprognostic (1.24e-2)" "unprognostic (1.40e-2)" "unprognostic (2.59e-2)" "unprognostic (1.61e-1)" "unprognostic (1.15e-2)" "unprognostic (5.92e-2)" 0.1 0.0 0.1 0.1 0.1 0.0 28.1 0.1 0.1 6.7 0.1 0.1 5.0 0.0 1.5 2.4 48.2 1.5 0.1 0.1 0.1 0.0 0.6 0.1 0.6 0.1 0.1 0.1 0.4 0.1 0.6 0.3 11.2 0.1 1.8 0.0 0.1 17.1 4.6 0.1 38.7 0.1 0.1 0.1 0.1 0.1 0.3 0.1 0.8 0.1 25.7 34.2 4.6 11.6 1.0 0.1 0.6 0.2 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 3.5 0.0 0.0 0.0 0.0 0.5 1.8 1.6 0.0 0.0 1.4 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.6 0.0 3.1 0.0 0.0 0.0 0.0 0.0 0.0 30.9 2.6 0.0 0.0 0.0 0.0 0.0 0.1 0.0 4.6 0.0 0.0 0.0 32.0 0.0 6.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.2 0.2 0.6 0.0 0.2 0.0 0.0 0.0 0.0 0.1 1.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.2 0.1 0.1 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.1 ALPL "HOPS, TNSALP" ENSG00000162551 "Alkaline phosphatase, liver/bone/kidney" P05186 1 21509372-21578412 "Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" Biomineralization Hydrolase "Cancer-related genes, Disease mutation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "blood: 73.3;liver: 52.7;lung: 45.1" "Cell line enhanced" "Detected in some" "HSkMC: 52.2;hTEC/SVTERT24-B: 40.8;LHCN-M2: 29.7;SCLC-21H: 26.0" "Cancer enhanced" "Detected in all" "testis cancer: 199.6" "Low region specificity" "Detected in all" "Cell type enriched" "Detected in single" 91 "neutrophil: 73.3" "Lineage enriched" "Detected in single" 127 "granulocytes: 73.3" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "HPA007105, HPA008765, CAB020829" Enhanced Approved Cytosol "Intracellular and membrane" 7300000 Cytosol "CAB020829: , HPA007105: AB_1078137, HPA008765: AB_1078138" "unprognostic (3.89e-2)" "unprognostic (1.27e-1)" "unprognostic (5.57e-2)" "unprognostic (1.19e-1)" "prognostic unfavourable (7.57e-4)" "unprognostic (3.05e-3)" "unprognostic (6.50e-3)" "unprognostic (1.01e-1)" "prognostic unfavourable (7.08e-4)" "unprognostic (1.17e-2)" "unprognostic (2.48e-3)" "unprognostic (1.74e-1)" "unprognostic (7.28e-2)" "unprognostic (1.73e-2)" "unprognostic (2.27e-1)" "unprognostic (9.70e-3)" "unprognostic (2.58e-1)" 15.9 22.7 4.5 17.6 6.0 2.6 10.6 2.2 7.8 2.2 2.1 4.1 0.7 1.9 3.7 1.1 2.0 5.7 2.8 10.9 5.7 4.2 29.7 52.7 45.1 28.1 5.3 4.8 1.2 4.3 2.4 4.1 2.2 7.7 2.6 1.3 18.3 3.1 6.6 0.9 1.8 2.7 2.5 3.8 19.6 1.8 2.9 2.7 0.5 3.7 1.7 3.9 7.1 8.4 0.5 0.0 73.3 0.0 0.0 0.0 0.0 0.0 0.0 1.5 0.0 0.2 1.9 3.3 0.1 0.7 0.2 0.4 0.2 0.0 0.6 2.2 0.0 0.0 8.9 0.0 0.1 0.0 0.6 0.0 1.1 1.0 0.5 0.0 0.2 52.2 0.0 40.8 0.1 0.0 0.0 0.0 29.7 0.0 0.0 0.0 11.9 0.0 0.0 1.1 0.0 0.0 0.0 26.0 0.3 0.0 0.0 0.1 0.0 0.0 0.0 1.5 1.2 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.2 0.0 0.0 0.8 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.1 0.0 0.0 73.3 0.0 0.0 0.0 0.0 0.0 4.5 6.0 2.2 7.8 5.7 4.2 5.3 4.8 7.7 2.7 BCKDHA "MSU, OVD1A" ENSG00000248098 "Branched chain keto acid dehydrogenase E1, alpha polypeptide" P12694 19 41397460-41425005 "Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins" Oxidoreductase "Disease mutation, Maple syrup urine disease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell line enhanced" "Detected in all" "U-266/70: 48.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" HPA036640 Supported "HPA036640: AB_10671964" "unprognostic (4.50e-2)" "unprognostic (6.85e-2)" "unprognostic (1.14e-1)" "unprognostic (8.58e-3)" "unprognostic (1.26e-2)" "prognostic favourable (9.37e-4)" "unprognostic (2.41e-2)" "unprognostic (8.55e-2)" "unprognostic (1.82e-1)" "unprognostic (1.48e-2)" "unprognostic (1.12e-2)" "unprognostic (1.53e-1)" "prognostic favourable (5.33e-10)" "unprognostic (1.73e-1)" "unprognostic (1.37e-1)" "prognostic unfavourable (3.27e-5)" "unprognostic (9.66e-2)" 18.4 36.1 11.5 9.2 14.9 11.4 12.9 9.3 19.3 12.5 11.2 16.6 25.0 11.2 11.0 11.2 31.0 15.0 12.4 41.1 10.8 9.5 23.4 47.6 12.3 17.0 16.0 17.6 13.8 28.2 15.7 12.6 13.4 12.7 12.6 8.8 15.0 23.1 31.1 61.7 15.6 10.4 10.8 11.2 13.2 22.0 21.2 13.5 15.8 21.8 25.3 15.9 14.0 15.1 16.5 45.9 17.6 38.0 25.9 19.7 27.1 14.2 26.2 2.3 14.0 6.6 4.0 6.0 3.5 6.7 6.9 8.8 6.0 9.9 11.5 7.9 3.7 5.7 4.4 7.1 3.6 12.0 12.6 8.0 13.7 5.6 14.1 8.4 5.9 7.3 10.2 4.6 10.2 13.3 8.0 21.8 6.2 12.9 7.2 5.1 3.9 6.5 8.7 7.8 27.4 9.7 6.7 10.2 12.2 12.4 28.2 8.6 14.5 22.6 10.0 7.4 7.6 4.3 7.5 48.8 19.7 11.3 26.8 15.7 8.6 13.5 36.9 17.6 15.8 38.0 18.2 16.5 15.9 16.1 45.9 16.4 13.4 15.3 10.9 25.9 26.1 17.6 19.7 27.1 11.5 14.9 9.3 19.3 10.8 9.5 16.0 17.6 12.7 13.5 BCKDHB ENSG00000083123 "Branched chain keto acid dehydrogenase E1 subunit beta" P21953 6 80106647-80346270 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" Oxidoreductase "Disease mutation, Maple syrup urine disease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 58.6" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA031580, HPA031956" Approved Supported Nucleoli,Mitochondria "Intracellular and membrane" Mitochondria Nucleoli "HPA031580: AB_10696054, HPA031956: " "unprognostic (4.23e-1)" "unprognostic (1.61e-1)" "unprognostic (9.50e-3)" "unprognostic (9.37e-3)" "unprognostic (1.66e-1)" "unprognostic (6.03e-2)" "unprognostic (6.84e-3)" "unprognostic (2.30e-2)" "unprognostic (1.94e-1)" "unprognostic (7.32e-3)" "unprognostic (2.67e-1)" "unprognostic (4.65e-2)" "prognostic favourable (5.54e-9)" "unprognostic (2.67e-1)" "unprognostic (1.12e-1)" "unprognostic (8.02e-2)" "unprognostic (1.49e-2)" 13.9 12.0 9.9 9.0 12.2 5.8 18.1 9.5 14.3 10.2 17.3 22.7 9.4 9.1 11.6 7.7 10.2 10.9 7.4 14.7 11.9 7.6 24.7 58.6 6.4 8.1 11.3 11.2 13.9 12.1 13.7 15.5 5.5 14.1 13.1 16.5 11.7 30.5 10.3 8.2 8.6 11.8 11.5 16.7 5.3 15.0 10.0 12.4 11.2 12.5 7.9 7.7 14.0 8.2 9.1 10.3 2.6 4.3 13.4 15.7 5.2 6.9 2.6 9.9 13.2 10.0 8.8 7.9 4.9 10.3 8.1 11.2 4.2 9.6 19.7 5.3 11.8 7.0 5.5 6.5 11.5 24.5 8.1 9.7 6.8 5.7 11.2 13.9 4.4 8.4 6.8 5.6 7.0 9.7 8.2 17.7 18.2 3.8 5.0 8.1 7.3 3.4 12.8 30.7 16.8 22.6 10.6 6.6 9.3 8.4 7.0 4.9 9.0 10.7 4.1 4.9 3.4 4.5 6.6 12.6 12.3 6.5 6.0 10.4 7.3 2.6 3.4 0.8 8.5 4.0 11.1 9.1 7.2 7.2 6.6 9.1 9.6 10.0 0.7 13.4 4.3 10.3 15.7 5.2 9.9 12.2 9.5 14.3 11.9 7.6 11.3 11.2 14.1 12.4 CA1 Car1 ENSG00000133742 "Carbonic anhydrase 1" P00915 8 85327608-85379014 "Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins" Lyase "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 6 "bone marrow: 156.0;intestine: 203.6" "Cell line enriched" "Detected in single" 1206 "HEL: 165.2" "Group enriched" "Detected in some" 10 "colorectal cancer: 3.4;stomach cancer: 0.9" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in single" "Low region specificity" "Detected in all" "HPA006558, CAB025790" Enhanced 7800000000 "CAB025790: , HPA006558: AB_1845989" "unprognostic (1.44e-1)" "unprognostic (7.56e-2)" "unprognostic (1.70e-1)" "unprognostic (3.57e-3)" "unprognostic (2.08e-2)" "unprognostic (1.66e-1)" "unprognostic (2.84e-2)" "unprognostic (2.03e-2)" "unprognostic (1.73e-2)" "unprognostic (6.12e-2)" "unprognostic (1.63e-1)" "unprognostic (1.04e-1)" "unprognostic (5.61e-2)" "unprognostic (3.01e-2)" "unprognostic (2.38e-1)" "unprognostic (3.95e-2)" 1.8 0.4 0.5 11.5 0.5 156.0 0.4 0.3 0.4 0.3 95.4 1.5 0.0 0.0 0.3 0.0 0.6 0.7 0.0 17.6 0.5 0.4 0.8 2.9 32.2 0.2 0.9 0.0 0.8 0.5 0.0 1.0 24.0 0.6 1.1 203.6 2.6 0.3 0.1 3.1 0.2 0.4 3.2 0.5 14.3 0.3 0.3 0.0 0.2 7.5 0.0 0.2 4.5 16.0 0.7 0.7 0.0 0.3 0.0 0.1 7.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 165.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.1 0.0 0.0 0.7 0.0 0.0 0.3 0.3 0.0 0.0 0.0 0.0 0.0 0.7 0.0 7.5 0.5 0.5 0.3 0.4 0.5 0.4 0.9 0.0 0.6 0.0 CA12 HsT18816 ENSG00000074410 "Carbonic anhydrase 12" O43570 15 63321378-63382161 "Disease related genes, Enzymes, FDA approved drug targets, Predicted membrane proteins" Lyase "Disease mutation, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "kidney: 103.5" "Cell line enhanced" "Detected in many" "A549: 38.2;ASC TERT1: 40.3;RT4: 40.5;SK-BR-3: 32.5;T-47d: 52.3;U-138 MG: 55.8;U-87 MG: 67.0" "Cancer enhanced" "Detected in all" "renal cancer: 109.3" "Low region specificity" "Detected in many" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "HPA008773, CAB025181, CAB062549, CAB068179, HPA073203" Enhanced Approved Nucleoplasm,Vesicles 29000 Nucleoplasm Vesicles "CAB025181: , CAB062549: , CAB068179: , HPA008773: AB_1078394, HPA073203: " "unprognostic (2.01e-1)" "unprognostic (8.38e-3)" "unprognostic (3.47e-1)" "unprognostic (3.25e-3)" "unprognostic (2.73e-2)" "unprognostic (2.47e-2)" "unprognostic (7.48e-2)" "unprognostic (3.43e-3)" "unprognostic (2.29e-1)" "unprognostic (4.67e-2)" "prognostic unfavourable (3.80e-6)" "unprognostic (2.59e-1)" "unprognostic (1.51e-1)" "unprognostic (2.38e-1)" "unprognostic (6.56e-2)" "unprognostic (7.26e-2)" "unprognostic (1.21e-1)" 3.7 0.3 4.7 15.0 27.4 0.3 14.5 3.7 2.3 15.7 32.0 2.6 5.0 0.4 9.8 12.3 42.8 8.5 2.6 1.6 4.9 1.4 103.5 0.3 1.2 0.3 1.8 0.2 2.1 43.8 0.3 3.9 5.9 16.9 3.8 30.3 8.5 8.2 17.9 0.5 44.1 2.4 18.1 0.1 0.4 2.2 1.3 6.7 0.0 1.7 18.4 25.9 10.6 14.5 0.3 0.2 0.6 0.7 0.3 0.2 0.0 0.0 38.2 0.6 0.0 5.1 40.3 2.0 2.7 2.5 0.4 0.7 0.2 0.0 0.0 9.4 2.2 0.2 0.0 1.8 1.1 0.0 1.3 0.0 2.6 0.0 0.1 0.0 0.0 15.2 2.1 11.6 3.7 0.4 0.0 0.0 0.5 22.0 0.0 0.0 0.6 6.0 0.0 0.0 0.0 0.0 40.5 0.3 0.0 0.1 32.5 0.0 52.3 0.0 0.0 55.8 3.0 1.8 0.0 0.0 0.0 0.0 67.0 0.0 0.1 0.3 0.0 0.0 0.1 0.0 0.0 0.0 0.2 0.0 0.0 0.3 0.1 0.2 0.6 0.3 0.7 0.2 0.1 0.0 4.7 27.4 3.7 1.3 4.9 1.4 1.8 0.2 16.9 6.7 CA13 "CAXIII, FLJ37995, MGC59868" ENSG00000185015 "Carbonic anhydrase 13" Q8N1Q1 8 85220587-85284073 "Enzymes, Predicted intracellular proteins" Lyase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 56.7" "Cell line enhanced" "Detected in many" "HEL: 16.1;RPTEC TERT1: 8.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Low cell type specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "HPA024689, CAB025567" Enhanced Uncertain Nucleoplasm,Nucleoli,Vesicles 100000 Nucleoli "Nucleoplasm, Vesicles" "CAB025567: , HPA024689: AB_1846004" "unprognostic (1.12e-2)" "unprognostic (2.20e-1)" "unprognostic (1.75e-1)" "unprognostic (9.16e-5)" "unprognostic (2.21e-2)" "unprognostic (2.08e-1)" "unprognostic (9.39e-2)" "unprognostic (7.90e-3)" "unprognostic (1.97e-1)" "unprognostic (1.34e-2)" "unprognostic (3.58e-2)" "unprognostic (3.13e-1)" "prognostic favourable (9.40e-4)" "unprognostic (7.59e-2)" "unprognostic (1.59e-1)" "unprognostic (1.55e-2)" "unprognostic (3.00e-1)" 2.6 2.6 2.0 1.9 3.1 0.5 2.9 2.4 2.4 3.2 18.2 0.8 0.0 14.2 1.8 1.7 6.7 1.4 25.6 5.8 1.6 1.9 10.4 17.1 9.5 2.4 2.0 0.1 2.2 1.6 9.3 6.5 1.0 5.7 2.6 3.7 1.9 7.0 1.0 1.9 7.1 56.7 1.9 5.2 2.2 7.0 0.9 0.9 0.4 10.3 3.9 5.6 2.9 5.2 0.8 2.1 3.2 2.5 0.5 0.5 1.0 0.3 0.4 0.9 0.1 0.6 0.7 0.4 1.1 1.1 0.1 3.1 7.5 5.8 0.4 0.5 1.3 2.4 2.3 3.0 0.2 1.6 1.0 16.1 2.1 6.9 1.6 0.2 0.7 2.4 0.5 0.2 1.3 1.7 4.1 3.2 2.7 0.1 0.3 0.2 0.5 0.5 0.2 2.4 0.2 8.7 0.3 0.3 0.1 0.5 0.0 1.6 0.6 0.8 1.6 3.0 4.3 0.1 1.6 1.3 0.6 2.0 6.3 2.3 2.8 3.2 2.5 1.3 0.4 0.7 0.2 0.2 0.2 0.1 2.1 0.8 0.3 0.5 0.9 0.5 0.8 0.9 0.1 1.0 2.0 3.1 2.4 2.4 1.6 1.9 2.0 0.1 5.7 0.9 CA14 ENSG00000118298 "Carbonic anhydrase 14" Q9ULX7 1 150257159-150265078 "Enzymes, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins" Lyase "FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 20.9;retina: 29.4;seminal vesicle: 16.5;skeletal muscle: 24.1" "Group enriched" "Detected in some" 18 "AF22: 28.0;AN3-CA: 16.6;NTERA-2: 21.8;SK-MEL-30: 55.8" "Group enriched" "Detected in many" 7 "glioma: 4.9;melanoma: 23.2" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA008482 Approved Approved "Plasma membrane" "Plasma membrane" "HPA008482: AB_1078395" "unprognostic (3.06e-2)" "unprognostic (1.67e-1)" "unprognostic (2.10e-2)" "unprognostic (3.25e-2)" "prognostic favourable (8.47e-4)" "unprognostic (7.28e-2)" "unprognostic (4.48e-2)" "unprognostic (1.49e-1)" "unprognostic (2.10e-1)" "unprognostic (2.47e-1)" "unprognostic (5.46e-2)" "unprognostic (1.73e-1)" "unprognostic (5.89e-3)" "unprognostic (1.91e-1)" "unprognostic (1.49e-1)" "unprognostic (1.22e-1)" "unprognostic (5.80e-2)" 0.1 0.3 4.6 0.2 5.2 0.9 0.3 1.4 6.8 0.1 1.7 10.8 0.1 0.3 0.1 0.5 1.6 1.3 0.7 4.4 6.4 4.1 0.3 6.3 0.2 0.2 11.3 3.2 1.4 0.3 0.8 0.1 0.3 4.4 3.2 0.7 29.4 0.6 16.5 24.1 3.7 0.6 0.5 20.9 0.3 0.8 0.5 2.7 0.1 0.9 0.1 0.1 0.2 0.1 2.8 2.2 2.1 2.0 0.2 1.6 0.2 0.2 0.0 28.0 16.6 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.3 0.1 0.1 1.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.2 0.0 0.0 21.8 0.2 0.0 0.0 0.0 0.0 0.0 0.7 0.4 0.0 0.1 55.8 0.2 0.1 0.0 0.0 0.0 0.0 0.1 0.2 1.2 0.1 0.1 0.1 0.0 0.0 0.9 1.3 1.6 2.0 0.6 2.0 1.0 1.2 0.2 2.8 1.2 1.3 2.1 0.2 0.5 2.2 0.0 0.2 4.6 5.2 1.4 4.7 6.4 4.1 11.3 3.2 4.4 2.7 CA2 "CA-II, CAII, Car2" ENSG00000104267 "Carbonic anhydrase 2" P00918 8 85463852-85481493 "Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins" Lyase "Disease mutation, FDA approved drug targets, Osteopetrosis" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 108.1;stomach 1: 171.5" "Cell line enhanced" "Detected in some" "HaCaT: 33.1;HEK 293: 139.1;THP-1: 58.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Cell type enhanced" "Detected in many" "basophil: 20.3" "Low lineage specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" "HPA001550, CAB010102" Enhanced 790000000 "CAB010102: AB_626796, HPA001550: AB_1078393" "unprognostic (6.78e-2)" "unprognostic (3.06e-2)" "unprognostic (1.05e-2)" "unprognostic (1.63e-1)" "unprognostic (2.59e-1)" "unprognostic (9.24e-2)" "unprognostic (1.74e-1)" "unprognostic (1.72e-2)" "unprognostic (1.07e-1)" "unprognostic (5.23e-2)" "unprognostic (1.57e-1)" "unprognostic (9.89e-2)" "prognostic favourable (5.57e-6)" "unprognostic (2.45e-1)" "unprognostic (2.03e-1)" "unprognostic (1.32e-1)" "unprognostic (6.49e-3)" 1.6 2.2 24.4 21.5 32.6 32.4 6.9 4.3 23.2 1.3 108.1 28.9 42.0 46.9 0.9 2.2 5.6 0.9 33.0 4.3 29.1 14.5 53.5 43.0 10.2 1.3 49.0 14.2 0.5 9.1 3.1 2.0 3.5 65.0 0.8 105.6 7.0 14.0 54.2 9.2 13.3 7.6 6.0 27.5 2.5 171.5 5.1 58.3 0.0 3.8 2.4 1.1 1.0 1.4 1.9 8.0 20.3 8.2 0.0 4.4 17.5 0.5 0.3 1.5 0.0 0.0 0.0 4.3 0.0 0.0 0.0 0.0 1.9 0.1 0.0 1.2 0.0 33.1 4.8 1.6 0.0 0.0 139.1 4.3 2.4 0.0 0.0 3.0 0.6 0.0 8.4 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 5.3 0.4 0.0 2.7 0.1 0.0 0.4 1.1 0.0 0.0 0.7 0.0 0.0 0.0 58.3 0.0 0.0 0.9 0.0 0.0 0.0 0.1 0.0 0.2 0.0 0.0 20.3 3.1 4.4 0.1 8.2 4.4 0.6 0.0 0.4 8.0 1.9 0.0 0.0 6.8 0.0 7.1 0.8 0.0 17.5 24.4 32.6 4.3 23.2 29.1 14.5 49.0 14.2 65.0 58.3 CA3 "CAIII, Car3" ENSG00000164879 "Carbonic anhydrase 3" P07451 8 85373436-85449040 "Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins" Lyase "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 12 "skeletal muscle: 347.5" "Group enriched" "Detected in some" 32 "HEL: 23.3;RH-30: 39.2" "Group enriched" "Detected in many" 7 "glioma: 23.1;prostate cancer: 9.4" "Not detected" "Not detected" "Cell type enhanced" "Detected in single" "plasmacytoid DC: 1.8" "Low lineage specificity" "Detected in single" "Low region specificity" "Detected in some" "Low region specificity" "Detected in many" "CAB004967, HPA021775, HPA026700" Enhanced 31000000 "CAB004967: AB_437014, HPA021775: AB_1845990, HPA026700: AB_1845991" "prognostic favourable (4.24e-6)" "unprognostic (1.40e-1)" "unprognostic (1.50e-2)" "unprognostic (2.22e-3)" "unprognostic (4.71e-2)" "unprognostic (8.43e-3)" "unprognostic (3.56e-2)" "unprognostic (4.04e-2)" "unprognostic (1.11e-1)" "unprognostic (3.68e-1)" "unprognostic (4.71e-2)" "unprognostic (3.54e-1)" "unprognostic (3.19e-2)" "unprognostic (1.18e-1)" "unprognostic (9.96e-2)" "unprognostic (1.39e-1)" "unprognostic (2.19e-1)" 18.0 0.4 0.2 0.1 0.2 0.5 0.6 0.2 0.1 0.5 0.3 0.0 0.1 0.1 0.6 29.0 9.5 1.0 0.2 1.3 0.2 0.1 0.2 0.2 4.1 0.0 0.1 0.0 0.1 0.1 0.0 0.3 0.0 0.0 6.6 0.0 0.0 5.5 0.2 347.5 0.3 0.4 1.4 0.1 0.1 0.3 0.5 0.0 0.0 0.3 14.1 3.4 0.7 0.5 0.5 1.8 0.0 0.0 0.0 0.8 0.2 0.9 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.5 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.2 0.1 23.3 0.0 0.5 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 39.2 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.3 0.0 0.8 0.0 0.0 0.0 1.8 0.0 0.2 0.2 0.2 0.2 0.1 0.2 0.1 0.1 0.0 0.0 0.0 CA4 "CAIV, Car4, RP17" ENSG00000167434 "Carbonic anhydrase 4" P22748 17 60149936-60170899 "Disease related genes, Enzymes, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins" Lyase "Disease mutation, FDA approved drug targets, Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 81.7" "Cell line enhanced" "Detected in some" "HEK 293: 1.4;HUVEC TERT2: 1.7;NTERA-2: 3.9;RPMI-8226: 1.5;RPTEC TERT1: 2.2" "Low cancer specificity" "Detected in many" "Region enriched" "Detected in many" 4 "cerebellum: 50.1" "Cell type enriched" "Detected in some" 7 "neutrophil: 37.0" "Lineage enriched" "Detected in single" 370 "granulocytes: 37.0" "Region enriched" "Detected in all" 5 "cerebellum: 336.9" "Low region specificity" "Detected in many" "HPA011089, HPA017258" Enhanced Supported Vesicles 190000 Vesicles "HPA011089: AB_1845996, HPA017258: AB_1845997" "unprognostic (2.07e-2)" "unprognostic (7.85e-2)" "unprognostic (1.55e-2)" "unprognostic (7.78e-3)" "unprognostic (8.42e-2)" "unprognostic (1.19e-1)" "unprognostic (3.19e-2)" "unprognostic (5.84e-2)" "unprognostic (7.76e-2)" "unprognostic (9.74e-2)" "unprognostic (1.54e-1)" "unprognostic (1.71e-2)" "unprognostic (2.68e-3)" "unprognostic (8.59e-2)" "unprognostic (1.43e-1)" "unprognostic (2.45e-1)" "unprognostic (4.57e-2)" 32.2 0.9 3.4 9.8 4.4 5.7 46.4 50.1 11.8 2.3 81.7 2.0 31.5 1.4 2.3 17.4 0.9 1.7 12.2 8.8 4.7 2.6 12.0 0.3 33.3 2.4 3.5 5.2 1.9 9.5 3.3 5.1 3.2 3.0 2.4 54.9 20.3 4.8 24.0 10.0 1.0 3.2 1.1 2.1 4.9 2.5 1.2 0.3 0.2 23.1 5.0 0.2 1.7 7.9 0.0 0.0 37.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.7 0.1 0.3 0.0 0.0 0.0 0.5 0.9 0.0 0.3 0.0 0.0 0.4 1.4 0.0 0.0 0.8 0.0 0.0 0.0 0.3 0.0 0.0 0.0 1.7 0.0 0.0 0.0 0.0 0.0 0.3 3.9 0.0 0.0 0.2 1.5 2.2 0.0 0.8 0.4 0.2 0.0 0.0 0.0 0.6 0.0 0.2 0.9 0.5 0.2 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 5.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 37.0 0.0 0.0 0.0 0.0 0.0 3.4 4.4 50.1 11.8 4.7 2.6 3.5 5.2 3.0 0.3 CA5A "CA5, CAV, CAVA" ENSG00000174990 "Carbonic anhydrase 5A" P35218 16 87881546-87936529 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" Lyase "Disease mutation" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 6 "liver: 26.4" "Cell line enhanced" "Detected in some" "Hep G2: 6.7" "Cancer enriched" "Detected in single" 26 "liver cancer: 2.0" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" "unprognostic (1.91e-1)" "unprognostic (8.64e-3)" "unprognostic (3.36e-2)" "unprognostic (6.11e-2)" "unprognostic (2.49e-2)" "unprognostic (2.96e-1)" "unprognostic (8.39e-3)" "unprognostic (3.50e-3)" "unprognostic (1.42e-2)" "unprognostic (1.12e-1)" "unprognostic (6.55e-2)" "unprognostic (4.23e-2)" "unprognostic (7.99e-3)" "unprognostic (1.77e-1)" "unprognostic (5.03e-3)" "unprognostic (3.37e-2)" "unprognostic (2.76e-2)" 0.0 0.0 0.3 0.8 0.4 2.7 0.0 0.1 0.7 0.0 0.0 0.1 0.1 0.6 0.0 0.0 0.0 0.0 0.4 0.3 0.0 26.4 0.2 0.3 0.4 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.3 0.7 0.1 0.0 0.3 0.8 0.0 0.3 0.1 0.0 0.0 0.0 1.9 1.6 4.7 1.1 1.9 1.1 0.4 0.2 0.3 0.3 0.7 0.1 0.0 0.5 0.4 0.1 0.0 0.1 0.5 0.6 0.6 0.2 0.2 0.5 0.2 0.2 0.1 0.4 0.3 0.4 1.1 6.7 0.0 0.4 1.7 0.7 0.0 0.2 0.4 0.3 0.4 1.6 0.1 0.5 0.2 1.0 0.5 0.6 0.4 0.4 0.2 0.2 0.5 0.4 0.2 0.2 0.3 0.1 0.6 0.3 0.4 0.8 0.2 0.5 0.3 0.7 0.4 0.4 0.5 0.9 0.4 4.1 1.1 1.0 0.8 0.7 0.8 0.9 0.8 0.6 0.3 1.9 1.1 1.1 4.7 1.9 0.7 1.6 0.5 0.4 CA5B ENSG00000169239 "Carbonic anhydrase 5B" Q9Y2D0 X 15688830-15788409 "Enzymes, Predicted intracellular proteins" Lyase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell line enhanced" "Detected in many" "ASC TERT1: 15.4;fHDF/TERT166: 17.5;hTERT-HME1: 23.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA012618 Uncertain Supported Mitochondria Mitochondria "HPA012618: AB_1846000" "unprognostic (1.62e-2)" "unprognostic (2.10e-3)" "unprognostic (2.86e-1)" "unprognostic (1.55e-3)" "unprognostic (1.16e-2)" "unprognostic (4.59e-5)" "unprognostic (2.50e-1)" "unprognostic (6.89e-4)" "unprognostic (4.11e-1)" "unprognostic (3.89e-3)" "unprognostic (1.54e-1)" "unprognostic (1.17e-1)" "prognostic favourable (6.66e-6)" "unprognostic (2.43e-1)" "unprognostic (1.38e-1)" "unprognostic (8.94e-2)" "unprognostic (3.08e-1)" 9.3 4.6 10.6 4.9 11.1 4.1 10.2 3.1 7.8 28.7 3.6 11.5 1.4 2.2 9.8 3.7 8.1 9.5 9.1 6.5 9.9 8.2 10.3 7.8 7.3 8.8 12.2 6.7 15.2 4.4 16.8 4.4 3.9 13.1 6.2 4.7 29.5 8.3 6.2 2.0 7.5 4.1 9.4 7.1 5.3 5.4 23.0 8.1 2.3 8.9 10.9 11.6 6.3 9.4 4.3 3.5 2.7 3.6 7.9 13.3 7.0 2.7 1.6 1.9 3.1 5.8 15.4 1.1 2.9 3.7 2.1 3.1 0.8 1.8 0.8 3.0 17.5 3.0 6.8 3.3 3.8 0.7 3.2 1.5 2.1 0.7 5.7 1.9 3.3 3.6 3.5 2.8 23.0 3.1 0.7 2.0 10.1 1.5 1.5 1.5 0.7 12.2 0.9 1.4 1.4 3.3 2.0 1.7 3.6 4.0 1.4 2.6 2.0 1.9 4.2 2.5 1.7 13.6 1.6 1.5 1.5 0.8 2.8 3.8 4.7 2.7 3.0 0.3 13.1 3.6 11.4 3.6 13.3 12.3 3.5 4.3 9.8 8.3 1.7 7.9 2.3 0.5 10.0 7.0 10.6 11.1 3.1 7.8 9.9 8.2 12.2 6.7 13.1 8.1 CA6 ENSG00000131686 "Carbonic anhydrase 6" P23280 1 8945867-8975092 "Enzymes, Predicted secreted proteins" Lyase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 50 "salivary gland: 1237.9" "Cell line enhanced" "Detected in many" "Daudi: 5.3;U-2197: 4.6" "Low cancer specificity" "Detected in some" "Not detected" "Not detected" "Cell type enhanced" "Detected in some" "naive CD8 T-cell: 15.4" "Lineage enriched" "Detected in many" 10 "T-cells: 15.4" "Low region specificity" "Detected in all" "HPA028550, HPA028692" Enhanced "Secreted to digestive system" 34000000 "HPA028550: AB_10600105, HPA028692: AB_10601883" "unprognostic (2.54e-5)" "unprognostic (1.09e-1)" "unprognostic (1.10e-1)" "unprognostic (2.37e-1)" "unprognostic (2.90e-1)" "unprognostic (9.28e-2)" "unprognostic (2.70e-3)" "unprognostic (1.24e-1)" "unprognostic (1.73e-1)" "unprognostic (5.93e-2)" "unprognostic (4.41e-2)" "unprognostic (4.29e-5)" "unprognostic (1.14e-1)" "unprognostic (1.31e-1)" "unprognostic (2.35e-1)" 0.3 0.0 0.1 0.0 0.1 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 1237.9 0.0 0.1 24.9 0.0 0.0 0.1 0.2 0.0 0.1 0.0 0.0 0.0 0.8 0.2 0.0 0.1 0.6 0.4 1.5 0.3 0.4 15.4 1.6 1.1 0.5 0.9 1.8 0.3 0.3 1.4 0.9 0.1 0.2 0.6 1.0 1.5 5.3 0.6 0.5 1.5 0.4 0.1 0.8 0.6 0.6 0.8 1.9 1.0 0.4 2.0 1.9 0.0 1.0 0.9 0.1 0.6 0.7 3.3 0.1 0.8 1.0 1.5 1.1 0.7 1.4 0.6 0.3 0.2 1.0 1.0 0.9 0.2 0.9 0.3 1.4 0.8 0.3 2.7 1.4 4.6 1.2 1.4 0.5 1.7 0.6 1.8 1.3 1.1 0.3 0.2 0.4 0.2 0.4 0.3 0.8 2.8 0.0 0.6 5.6 15.4 1.5 0.4 0.2 0.4 0.3 1.6 0.1 0.1 0.0 0.0 0.1 0.1 0.1 0.0 0.0 0.0 CA7 ENSG00000168748 "Carbonic anhydrase 7" P43166 16 66844379-66854153 "Enzymes, FDA approved drug targets, Predicted intracellular proteins" Lyase "FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 5 "intestine: 37.2" "Cell line enhanced" "Detected in some" "CACO-2: 1.2;HAP1: 1.8;NTERA-2: 1.5;REH: 3.3;SCLC-21H: 2.7;THP-1: 5.5" "Cancer enhanced" "Detected in some" "colorectal cancer: 0.9" "Low region specificity" "Detected in many" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" HPA047237 Uncertain "HPA047237: " "unprognostic (8.77e-4)" "unprognostic (5.23e-4)" "unprognostic (1.57e-1)" "unprognostic (1.96e-2)" "unprognostic (2.19e-1)" "unprognostic (2.16e-2)" "unprognostic (7.90e-2)" "unprognostic (1.59e-1)" "unprognostic (1.84e-2)" "unprognostic (9.62e-2)" "unprognostic (1.69e-2)" "unprognostic (7.12e-3)" "unprognostic (8.47e-2)" "unprognostic (5.20e-1)" "unprognostic (1.90e-2)" "unprognostic (6.46e-2)" 0.2 0.2 3.2 0.4 7.5 0.2 0.2 3.9 7.7 0.2 37.2 0.3 0.0 4.8 0.3 0.9 0.3 0.2 0.2 0.2 6.3 0.5 0.2 0.2 0.2 0.2 0.7 2.9 0.2 0.2 0.2 0.0 0.2 1.8 0.2 32.0 0.0 1.1 0.4 0.2 0.2 22.8 1.0 0.1 0.2 0.2 0.5 1.3 0.1 0.2 0.0 0.2 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.2 0.0 0.4 0.0 0.0 1.8 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.5 0.9 3.3 0.0 0.0 0.0 0.0 2.7 0.0 0.0 0.0 0.0 0.0 5.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.2 7.5 3.9 7.7 6.3 0.5 0.7 2.9 1.8 1.3 CA8 "CALS, CARP" ENSG00000178538 "Carbonic anhydrase 8" P35219 8 60187347-60281412 "Cancer-related genes, Disease related genes, Predicted intracellular proteins" "Cancer-related genes, Disease mutation, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "blood: 41.0;brain: 26.8;parathyroid gland: 56.8" "Cell line enhanced" "Detected in some" "HEK 293: 12.6;K-562: 22.7;NB-4: 13.1;WM-115: 6.6" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Cell type enriched" "Detected in some" 20 "basophil: 41.0" "Lineage enriched" "Detected in many" 20 "granulocytes: 41.0" "Region enriched" "Detected in some" 37 "cerebellum: 1413.4" "Region enriched" "Detected in all" 9 "cerebellum: 163.0" "HPA024748, CAB025545, CAB047309" Enhanced "CAB025545: , CAB047309: , HPA024748: AB_1846003" "unprognostic (1.55e-1)" "unprognostic (2.89e-2)" "unprognostic (4.43e-2)" "unprognostic (3.46e-3)" "unprognostic (6.67e-2)" "unprognostic (3.19e-1)" "unprognostic (3.85e-2)" "unprognostic (3.54e-2)" "unprognostic (1.28e-1)" "unprognostic (1.19e-1)" "prognostic favourable (5.79e-5)" "unprognostic (3.23e-2)" "unprognostic (1.68e-2)" "unprognostic (2.12e-1)" "unprognostic (1.71e-2)" "unprognostic (1.95e-1)" "unprognostic (1.41e-1)" 2.3 1.5 9.2 1.1 11.6 1.1 6.5 26.8 6.9 6.3 2.2 3.6 0.6 1.8 2.8 12.8 0.9 2.5 1.0 3.8 7.8 6.0 7.4 0.6 1.6 1.0 4.2 5.3 0.7 3.0 56.8 9.8 8.1 3.4 3.3 3.1 1.5 6.6 0.9 2.0 0.9 1.7 1.3 1.9 1.3 5.9 9.3 6.2 1.7 0.7 1.3 1.0 1.3 2.1 0.1 2.0 41.0 0.0 0.0 0.0 0.0 0.0 2.9 3.9 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.8 0.0 0.0 1.3 0.0 0.1 0.0 12.6 5.2 0.0 0.0 4.2 2.1 1.4 0.0 0.0 0.0 0.0 0.0 22.7 0.2 0.0 0.0 3.6 13.1 0.2 0.0 0.0 0.0 0.3 0.5 1.0 5.8 0.0 0.0 1.2 0.0 5.3 0.8 0.0 0.0 0.4 0.0 0.0 0.2 0.0 0.0 0.0 0.0 6.6 41.0 0.0 0.3 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 9.2 11.6 26.8 6.9 7.8 6.0 4.2 5.3 3.4 6.2 CA9 "CAIX, MN" ENSG00000107159 "Carbonic anhydrase 9" Q16790 9 35673856-35681159 "Enzymes, Predicted intracellular proteins, Predicted membrane proteins" Lyase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 8 "gallbladder: 70.4;pancreas: 47.4;stomach 1: 70.8" "Cell line enhanced" "Detected in some" "A-431: 39.6;HDLM-2: 20.7;U-87 MG: 83.1" "Low cancer specificity" "Detected in many" "Region enriched" "Detected in single" 10 "cerebellum: 7.3" "Cell type enhanced" "Detected in single" "plasmacytoid DC: 1.1" "Low lineage specificity" "Detected in single" "Region enriched" "Detected in some" 4 "cerebellum: 13.8" "Low region specificity" "Detected in all" "CAB005100, CAB017107, HPA055207" Enhanced Enhanced "Plasma membrane,Cytosol" "Intracellular and membrane" "Plasma membrane" Cytosol "CAB005100: AB_2066539, CAB017107: , HPA055207: " "unprognostic (8.01e-3)" "unprognostic (1.34e-2)" "unprognostic (2.28e-1)" "unprognostic (2.00e-2)" "unprognostic (1.59e-2)" "unprognostic (1.15e-1)" "prognostic unfavourable (1.71e-5)" "unprognostic (1.47e-2)" "unprognostic (3.90e-2)" "unprognostic (1.29e-1)" "unprognostic (6.24e-3)" "unprognostic (1.13e-1)" "prognostic unfavourable (2.22e-7)" "unprognostic (7.29e-2)" "prognostic favourable (9.50e-4)" "unprognostic (2.97e-3)" "unprognostic (8.67e-2)" 1.0 0.1 0.0 0.1 0.3 0.0 0.0 7.3 0.7 0.5 7.2 0.1 0.2 6.7 0.1 1.5 0.3 0.1 70.4 0.7 0.0 0.0 0.1 0.7 0.1 0.0 0.0 0.0 0.7 47.4 0.0 0.2 0.7 0.4 0.2 0.0 0.1 0.0 0.0 0.0 2.6 8.0 0.0 0.4 0.0 70.8 1.4 0.0 0.0 0.0 0.0 0.0 1.3 0.2 0.0 1.1 0.0 0.0 0.4 0.1 0.0 39.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.5 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.2 0.3 20.7 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 2.1 0.0 0.1 0.3 0.0 0.0 0.0 0.1 0.0 0.0 0.0 4.2 0.0 0.0 1.0 0.0 0.0 0.0 83.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 1.1 0.0 0.0 0.0 0.3 7.3 0.7 0.0 0.0 0.0 0.0 0.4 0.0 CAT ENSG00000121691 Catalase P04040 11 34438925-34472062 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins" "Hydrogen peroxide" "Mitogen, Oxidoreductase, Peroxidase" "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "blood: 258.3;liver: 184.8" "Cell line enhanced" "Detected in many" "HL-60: 75.2;THP-1: 62.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Cell type enriched" "Detected in all" 13 "eosinophil: 258.3" "Lineage enriched" "Detected in all" 13 "granulocytes: 258.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB001515, HPA051282, HPA055838" Enhanced Enhanced Vesicles 960000000 Vesicles "CAB001515: AB_384710, HPA051282: AB_2681419, HPA055838: AB_2682937" "unprognostic (3.62e-2)" "unprognostic (2.72e-1)" "unprognostic (3.59e-3)" "unprognostic (5.43e-2)" "unprognostic (4.44e-2)" "unprognostic (5.80e-3)" "prognostic favourable (9.67e-4)" "unprognostic (9.95e-3)" "unprognostic (3.22e-1)" "unprognostic (7.23e-2)" "unprognostic (3.34e-2)" "unprognostic (9.77e-2)" "prognostic favourable (1.96e-8)" "unprognostic (1.01e-1)" "unprognostic (7.31e-2)" "unprognostic (4.77e-2)" "unprognostic (6.59e-3)" 70.0 33.0 9.4 10.1 9.6 54.2 36.1 3.1 7.7 15.3 26.6 18.6 15.7 22.2 13.5 9.5 14.8 14.2 19.0 22.4 10.7 5.2 50.4 184.8 26.1 21.3 14.5 6.0 11.0 24.7 7.1 5.0 16.4 10.2 23.2 11.3 11.4 14.5 13.2 27.8 19.7 29.2 11.6 11.3 17.9 15.9 6.2 11.6 23.4 41.7 14.9 11.5 20.4 24.9 7.6 19.9 258.3 17.5 5.5 5.0 17.8 6.1 6.8 5.0 7.8 48.4 21.1 10.6 7.8 9.9 8.8 9.7 3.8 6.2 15.2 7.6 15.5 14.7 8.4 8.5 9.8 13.2 7.7 12.8 7.3 21.9 5.7 75.2 6.4 11.3 5.9 2.6 1.0 10.6 26.5 6.3 11.1 5.8 15.4 13.4 0.0 16.6 10.9 23.8 12.4 24.1 23.3 2.6 4.0 8.8 14.2 11.6 20.3 62.8 7.5 5.3 5.2 13.2 4.6 5.1 2.9 3.2 10.4 51.8 3.8 12.5 17.5 258.3 3.2 14.7 3.8 7.6 3.8 3.6 19.9 6.8 3.8 4.0 17.1 5.5 15.5 13.4 5.0 17.8 9.4 9.6 3.1 7.7 10.7 5.2 14.5 6.0 10.2 11.6 CMA1 ENSG00000092009 "Chymase 1" P23946 14 24505353-24508265 "Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell line enhanced" "Detected in some" "AF22: 1.6;BEWO: 1.5;HL-60: 1.7;TIME: 1.5;U-937: 3.2" "Low cancer specificity" "Detected in some" "Not detected" "Not detected" "Cell type enriched" "Detected in single" 4 "T-reg: 1.5" "Lineage enriched" "Detected in single" 4 "T-cells: 1.5" "Low region specificity" "Detected in single" "CAB000363, HPA052634" Enhanced "Secreted to blood" 3000000 "CAB000363: AB_2083616, HPA052634: " "unprognostic (1.37e-1)" "unprognostic (2.27e-3)" "unprognostic (2.04e-1)" "unprognostic (7.07e-3)" "unprognostic (1.48e-2)" "unprognostic (1.19e-1)" "unprognostic (5.79e-2)" "unprognostic (2.21e-1)" "unprognostic (8.91e-3)" "unprognostic (4.19e-3)" "unprognostic (1.29e-4)" "unprognostic (2.52e-3)" "unprognostic (7.78e-2)" "unprognostic (7.37e-2)" "unprognostic (4.98e-3)" 12.3 0.2 0.2 2.9 0.2 0.0 15.9 0.2 0.2 7.3 6.2 0.2 1.2 0.1 2.9 6.0 8.3 1.0 10.0 10.3 0.2 0.2 2.0 0.8 1.1 1.6 0.2 0.2 0.6 0.9 0.5 0.5 0.7 0.3 6.0 6.9 3.0 5.9 1.3 1.2 13.0 5.3 6.2 0.2 0.5 2.4 2.7 0.2 1.0 0.4 7.9 3.9 4.1 2.0 0.3 0.0 0.0 0.0 0.0 1.5 0.5 0.0 0.0 1.6 0.0 0.0 0.0 1.5 0.3 0.0 0.0 0.0 0.0 0.4 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.8 0.0 1.7 0.7 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.8 0.4 0.9 1.1 1.1 0.0 0.0 0.5 0.5 0.0 0.0 0.0 0.8 0.0 0.8 1.5 0.0 0.3 0.3 0.3 0.9 1.0 0.3 0.0 3.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 1.5 0.5 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.3 0.2 CNP ENSG00000173786 "2',3'-cyclic nucleotide 3' phosphodiesterase" P09543 17 41966741-41977731 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Hydrolase, RNA-binding" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in all" 4 "brain: 211.7" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Cell type enhanced" "Detected in all" "plasmacytoid DC: 49.1" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB002672, HPA023266, HPA023278, HPA023280, HPA023338" Enhanced Supported Enhanced Nucleoplasm,Cytosol 730000 Nucleoplasm Cytosol "CAB002672: , HPA023266: AB_1847058, HPA023278: AB_1847060, HPA023280: AB_1847061, HPA023338: AB_1847062" "unprognostic (2.17e-1)" "unprognostic (4.48e-2)" "unprognostic (3.85e-3)" "unprognostic (1.41e-1)" "unprognostic (3.09e-1)" "unprognostic (9.71e-2)" "unprognostic (2.58e-3)" "unprognostic (2.08e-1)" "unprognostic (2.23e-1)" "unprognostic (1.62e-1)" "unprognostic (5.76e-3)" "unprognostic (1.87e-1)" "unprognostic (2.99e-3)" "unprognostic (1.60e-1)" "unprognostic (1.55e-1)" "unprognostic (8.86e-2)" "unprognostic (1.10e-3)" 9.1 8.9 51.4 9.5 72.8 6.7 8.1 13.4 125.3 10.3 7.5 211.7 2.3 7.1 8.0 12.7 15.0 9.3 10.8 7.6 78.4 40.7 14.7 9.6 6.7 10.5 86.7 49.0 11.2 9.2 5.8 4.4 7.8 66.7 11.7 6.4 3.6 15.1 13.2 7.6 11.1 6.4 10.1 160.2 7.1 7.4 4.6 63.5 2.1 7.2 2.2 11.2 9.8 5.7 9.9 49.1 7.3 13.1 7.3 7.5 9.1 13.7 23.5 22.3 27.5 19.1 18.0 9.6 17.2 26.5 44.8 50.6 18.4 12.6 14.6 13.9 22.4 23.7 15.0 11.4 15.6 14.5 19.0 14.2 16.2 31.9 20.6 13.8 12.9 29.7 8.2 24.5 6.0 20.4 10.0 12.0 15.6 8.7 35.4 12.5 5.2 16.8 22.1 32.8 14.2 11.9 14.1 13.1 17.7 21.8 32.9 38.3 14.7 20.7 20.4 17.5 19.2 23.7 20.3 13.5 15.3 11.7 17.3 10.7 68.2 4.9 12.1 7.3 7.5 13.1 5.9 9.9 6.5 6.0 11.1 7.0 5.9 6.9 2.6 7.3 10.3 49.1 7.2 9.1 51.4 72.8 13.4 93.8 78.4 40.7 86.7 49.0 66.7 63.5 CPA1 CPA ENSG00000091704 "Carboxypeptidase A1" P15085 7 130380339-130388114 "Enzymes, Predicted intracellular proteins, Predicted secreted proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 3231 "pancreas: 3541.6" "Cell line enriched" "Detected in some" 5 "AN3-CA: 15.8" "Cancer enriched" "Detected in some" 639 "pancreatic cancer: 1377.7" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in many" "HPA021836, CAB025197, HPA052215" Enhanced "Secreted to digestive system" 17000000 "CAB025197: , HPA021836: AB_1846005, HPA052215: " "unprognostic (8.41e-2)" "unprognostic (9.24e-4)" "unprognostic (5.22e-2)" "unprognostic (1.76e-1)" "unprognostic (3.97e-1)" "unprognostic (1.76e-1)" "unprognostic (2.27e-1)" "unprognostic (1.15e-2)" "unprognostic (1.35e-1)" "unprognostic (1.34e-6)" "unprognostic (4.99e-1)" "unprognostic (1.67e-1)" "unprognostic (2.16e-1)" "unprognostic (4.37e-2)" 0.3 0.0 0.1 0.1 0.1 0.0 0.1 0.1 0.2 0.1 0.1 0.1 0.1 0.2 0.1 0.1 0.1 0.0 0.1 0.3 0.1 0.0 0.1 0.1 0.1 0.1 0.1 0.1 1.0 3541.6 0.0 0.1 0.1 0.1 0.1 0.0 0.1 0.3 0.1 0.1 0.0 0.1 0.1 0.1 0.1 0.1 0.4 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 15.8 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 1.9 0.0 0.0 0.0 0.0 0.0 1.3 0.0 0.0 0.0 0.5 1.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 2.9 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.2 2.3 0.0 0.3 0.0 1.9 0.3 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.1 0.1 0.1 0.2 0.1 0.0 0.1 0.1 0.1 0.1 CPA2 ENSG00000158516 "Carboxypeptidase A2" P48052 7 130266827-130289798 "Enzymes, Predicted secreted proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 529 "pancreas: 1357.9" "Cell line enhanced" "Detected in some" "AN3-CA: 4.4;CACO-2: 7.3;RH-30: 6.1;SCLC-21H: 3.3" "Cancer enriched" "Detected in many" 60 "pancreatic cancer: 411.4" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in some" "Low region specificity" "Detected in many" "HPA020342, HPA021317" Enhanced Approved "Golgi apparatus" "Secreted to digestive system" 1500000 "Golgi apparatus" "HPA020342: AB_1846007, HPA021317: AB_1846008" "unprognostic (1.12e-1)" "unprognostic (3.97e-1)" "unprognostic (4.21e-2)" "unprognostic (1.82e-2)" "unprognostic (1.38e-1)" "unprognostic (6.76e-2)" "unprognostic (4.65e-2)" "unprognostic (1.08e-1)" "unprognostic (1.40e-1)" "unprognostic (1.84e-1)" "unprognostic (2.66e-1)" "unprognostic (3.84e-5)" "unprognostic (7.52e-2)" "unprognostic (1.42e-1)" "unprognostic (7.12e-2)" "unprognostic (8.48e-2)" 0.1 0.0 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.1 0.4 0.1 0.1 0.3 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.1 0.1 0.1 0.4 1357.9 0.0 0.1 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.1 0.0 1.0 0.1 0.2 0.1 2.5 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.9 4.4 0.0 0.1 0.0 0.0 0.0 0.7 0.0 7.3 0.0 0.0 1.0 0.0 0.0 1.4 0.0 0.1 1.0 0.0 0.0 0.8 0.0 0.1 0.0 0.0 0.1 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.9 0.4 0.0 6.1 0.1 0.1 0.6 3.3 0.0 0.2 0.0 2.0 0.0 0.2 0.0 0.0 1.1 0.8 0.6 0.0 0.7 0.2 0.8 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.1 CPA5 ENSG00000158525 "Carboxypeptidase A5" Q8WXQ8 7 130344816-130368730 "Enzymes, Predicted intracellular proteins, Predicted secreted proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 17 "blood: 25.2;testis: 30.4" "Cell line enhanced" "Detected in some" "RH-30: 10.9;RT4: 4.9;U-266/84: 8.2" "Not detected" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 4 "memory CD4 T-cell: 8.0;naive CD8 T-cell: 20.3;T-reg: 25.2" "Lineage enriched" "Detected in single" 114 "T-cells: 25.2" "Not detected" "Not detected" "Low region specificity" "Detected in many" HPA020322 Approved Nucleoplasm "Secreted in male reproductive system" Nucleoplasm "HPA020322: AB_10960562" "unprognostic (2.44e-1)" "unprognostic (3.76e-1)" "unprognostic (1.50e-1)" "unprognostic (5.94e-2)" "unprognostic (4.96e-2)" "unprognostic (7.10e-3)" "unprognostic (1.64e-2)" "unprognostic (1.41e-2)" "unprognostic (3.26e-1)" "unprognostic (5.02e-2)" "unprognostic (5.83e-4)" "unprognostic (1.43e-1)" "unprognostic (8.88e-13)" "unprognostic (5.16e-2)" "unprognostic (1.32e-1)" "unprognostic (8.81e-2)" "unprognostic (3.08e-2)" 0.1 0.1 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.0 0.1 0.4 0.1 0.0 0.1 0.1 0.1 0.4 0.1 0.1 0.1 1.6 0.1 0.1 0.1 0.4 0.0 1.0 0.5 0.1 0.1 0.0 0.1 0.1 0.1 0.1 0.8 0.4 0.1 0.1 1.6 0.0 30.4 0.1 0.1 0.1 0.1 0.7 0.8 0.1 0.0 0.0 0.2 0.0 0.0 25.2 3.1 0.8 0.0 0.1 0.6 0.0 0.0 0.0 0.4 3.2 0.2 0.4 2.4 0.0 0.0 0.0 0.0 0.1 0.4 0.6 0.0 0.0 1.8 0.7 0.7 1.2 0.5 0.0 0.0 0.0 1.1 0.0 1.2 0.0 0.0 1.6 0.1 0.0 0.4 0.0 0.8 0.0 0.0 10.9 0.3 1.4 4.9 1.4 0.2 0.0 3.1 0.0 0.0 0.0 0.0 0.0 2.2 0.0 0.1 0.0 8.2 0.0 0.4 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.3 0.0 8.0 4.1 0.0 0.0 2.1 20.3 0.0 0.0 0.0 0.0 25.2 3.1 0.1 0.1 0.1 0.1 0.1 0.4 0.1 0.1 0.1 0.1 CPA6 CPAH ENSG00000165078 "Carboxypeptidase A6" Q8N4T0 8 67422038-67746385 "Disease related genes, Enzymes, Potential drug targets, Predicted secreted proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Disease mutation, Epilepsy" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 16.2;prostate: 10.6;retina: 13.0" "Cell line enhanced" "Detected in some" "ASC TERT1: 2.0;CACO-2: 6.2;EFO-21: 3.5;Hep G2: 9.5" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Region enriched" "Detected in single" 10 "olfactory region: 15.5" "Low region specificity" "Detected in all" "Secreted to extracellular matrix" "unprognostic (2.85e-2)" "unprognostic (1.95e-1)" "unprognostic (1.72e-2)" "unprognostic (1.14e-1)" "unprognostic (2.58e-1)" "unprognostic (2.24e-1)" "unprognostic (2.08e-1)" "unprognostic (2.88e-1)" "unprognostic (9.35e-2)" "unprognostic (1.65e-1)" "unprognostic (5.23e-2)" "unprognostic (6.99e-2)" "unprognostic (3.57e-4)" "unprognostic (9.61e-5)" "unprognostic (1.75e-1)" "unprognostic (9.09e-2)" "unprognostic (1.41e-2)" 0.2 0.1 0.1 9.8 0.1 0.2 0.2 0.1 0.1 9.4 16.2 0.7 0.8 0.2 8.3 1.7 3.7 0.2 0.3 0.1 0.2 0.1 0.3 0.1 0.7 0.1 0.2 0.0 0.1 0.1 0.1 0.2 0.3 0.3 10.6 7.2 13.0 0.1 0.7 0.1 0.2 1.3 3.4 0.7 0.3 0.5 1.3 0.0 0.0 0.2 1.5 0.6 4.1 5.5 0.0 0.6 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.2 0.0 0.0 6.2 0.0 0.0 3.5 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 9.5 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 1.1 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 1.7 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.1 0.1 0.1 0.1 0.2 0.1 0.2 0.0 0.3 0.0 CYB5R1 "humb5R2, NQO3A2" ENSG00000159348 "Cytochrome b5 reductase 1" Q9UHQ9 1 202961869-202967280 "Enzymes, Predicted intracellular proteins" "Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism" Oxidoreductase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 119.2" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA010641, HPA014147" Enhanced Uncertain Nucleoli,Mitochondria,Cytosol 860000 "Nucleoli, Mitochondria, Cytosol" "HPA010641: AB_1078600, HPA014147: AB_1847370" "unprognostic (6.36e-2)" "unprognostic (8.51e-2)" "unprognostic (1.16e-2)" "prognostic favourable (1.14e-4)" "unprognostic (1.86e-2)" "unprognostic (4.34e-2)" "unprognostic (8.46e-2)" "unprognostic (1.28e-1)" "unprognostic (4.03e-1)" "unprognostic (1.03e-1)" "unprognostic (5.79e-2)" "unprognostic (2.89e-1)" "unprognostic (1.73e-2)" "unprognostic (2.33e-1)" "unprognostic (6.14e-2)" "unprognostic (2.37e-3)" "unprognostic (1.69e-1)" 9.6 14.5 7.8 5.0 8.4 3.9 16.9 6.2 11.0 11.6 7.5 8.7 10.6 4.4 10.1 32.3 13.7 16.4 9.2 33.9 7.3 9.2 15.5 18.4 10.1 11.7 10.0 9.1 10.8 11.1 16.3 11.1 63.8 11.9 10.5 5.0 15.7 14.4 10.1 119.2 28.5 6.9 10.6 7.4 10.8 18.6 20.1 6.7 11.7 13.5 26.4 10.0 13.6 10.1 20.2 21.9 25.7 33.3 17.2 26.5 28.8 8.3 5.2 4.6 9.4 42.9 9.9 45.1 16.8 15.8 10.9 9.8 4.3 9.9 5.2 14.3 16.7 46.3 3.7 14.4 7.2 7.5 9.5 2.9 6.3 4.9 15.5 2.5 7.4 15.8 47.6 12.0 6.6 7.2 8.8 9.4 39.4 9.8 3.2 2.2 3.0 10.0 5.3 22.2 11.1 10.3 10.0 3.9 4.8 9.4 31.4 13.6 14.5 5.7 7.0 12.5 5.3 4.7 9.3 8.8 10.4 2.4 13.8 3.9 9.3 11.6 33.3 25.6 16.7 24.2 22.2 13.6 19.3 17.8 21.9 20.2 26.5 18.8 25.7 17.2 15.7 15.1 19.1 28.8 7.8 8.4 6.2 11.0 7.3 9.2 10.0 9.1 11.9 6.7 CYB5R2 ENSG00000166394 "Cytochrome b5 reductase 2" Q6BCY4 11 7665100-7677222 "Enzymes, Predicted intracellular proteins, Predicted membrane proteins" "Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism" Oxidoreductase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "testis: 58.8" "Cell line enhanced" "Detected in many" "BJ hTERT+: 41.6;BJ hTERT+ SV40 Large T+: 22.3;BJ hTERT+ SV40 Large T+ RasG12V: 20.2;HBF TERT88: 17.8;NTERA-2: 23.4;WM-115: 32.0" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Cell type enhanced" "Detected in some" "eosinophil: 5.9;memory B-cell: 12.2" "Group enriched" "Detected in many" 9 "B-cells: 12.2;granulocytes: 5.9" "Low region specificity" "Detected in many" "HPA038962, HPA061707" Enhanced Approved "Nucleoplasm,Golgi apparatus" "Golgi apparatus" Nucleoplasm "HPA038962: AB_10675954, HPA061707: " "unprognostic (1.47e-1)" "unprognostic (2.56e-2)" "unprognostic (8.90e-3)" "unprognostic (4.41e-2)" "unprognostic (4.13e-3)" "unprognostic (1.60e-2)" "unprognostic (4.02e-2)" "unprognostic (2.48e-1)" "unprognostic (3.41e-2)" "unprognostic (1.30e-2)" "unprognostic (2.64e-3)" "unprognostic (1.10e-1)" "unprognostic (4.78e-2)" "unprognostic (1.40e-1)" "unprognostic (8.16e-2)" "unprognostic (1.70e-1)" "unprognostic (7.01e-2)" 3.3 1.9 9.3 2.8 12.1 1.9 7.7 3.1 12.3 6.6 2.3 26.1 4.2 1.3 10.0 13.1 8.0 5.2 3.4 2.0 11.2 5.3 2.4 2.5 4.6 3.8 22.3 7.3 14.9 2.2 23.1 0.6 6.7 11.6 7.8 2.7 12.2 12.8 11.6 0.8 23.4 1.7 6.8 12.4 2.0 2.2 58.8 14.5 0.2 2.6 6.7 4.9 5.9 7.1 12.2 0.0 5.9 1.0 0.0 0.2 0.7 2.2 1.1 0.5 0.0 0.1 0.6 7.7 14.5 41.6 22.3 20.2 0.2 3.1 0.0 3.5 7.4 0.2 0.0 0.1 17.8 0.0 0.0 0.0 1.2 0.3 12.1 0.1 2.2 6.1 0.4 0.0 1.2 1.8 2.2 0.0 0.1 0.0 0.0 0.0 23.4 1.1 11.0 0.0 0.0 0.0 1.5 0.0 0.2 0.1 9.3 0.6 1.6 3.0 0.0 2.1 0.0 0.1 1.1 0.0 0.0 3.4 0.1 0.0 32.0 0.0 1.0 5.9 0.0 0.5 0.0 12.2 0.2 0.0 0.0 2.3 0.0 0.0 0.1 0.0 0.4 0.0 0.0 0.7 9.3 12.1 3.1 12.3 11.2 5.3 22.3 7.3 11.6 14.5 CYB5R3 DIA1 ENSG00000100243 "Cytochrome b5 reductase 3" P00387 22 42617840-42649568 "Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Cholesterol biosynthesis, Cholesterol metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism" Oxidoreductase "Cancer-related genes, Disease mutation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell line enhanced" "Detected in all" "ASC diff: 115.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA001566 Approved Supported "Endoplasmic reticulum" 67000000 "Endoplasmic reticulum" "HPA001566: AB_1078601" "unprognostic (4.73e-2)" "unprognostic (2.93e-1)" "unprognostic (1.79e-1)" "unprognostic (1.89e-1)" "unprognostic (3.05e-1)" "unprognostic (1.04e-2)" "prognostic unfavourable (2.13e-5)" "unprognostic (2.45e-1)" "unprognostic (8.22e-3)" "unprognostic (3.01e-1)" "unprognostic (2.72e-2)" "unprognostic (6.76e-2)" "unprognostic (3.33e-3)" "unprognostic (1.31e-1)" "unprognostic (1.64e-1)" "unprognostic (1.92e-1)" "unprognostic (5.24e-2)" 79.7 57.1 33.2 22.8 32.6 19.3 86.8 19.5 33.1 52.4 31.9 37.6 51.8 25.9 51.9 35.0 39.1 39.3 38.6 86.4 31.3 24.1 43.3 78.2 43.5 30.3 31.8 25.4 58.8 21.9 15.1 27.2 32.1 33.9 40.6 21.3 37.9 29.3 96.4 34.4 43.1 32.5 55.5 36.3 20.2 33.7 44.0 25.9 14.1 30.1 28.4 23.2 43.4 53.5 28.6 37.6 70.3 39.7 14.2 22.3 19.7 16.2 10.4 17.2 10.5 115.5 91.8 10.1 47.8 44.4 35.7 31.9 13.6 12.8 7.7 21.4 88.4 15.0 11.4 23.7 18.4 8.3 25.6 10.9 18.0 26.2 29.4 15.2 20.4 55.3 18.8 25.7 17.1 29.5 9.4 40.0 48.5 17.9 14.9 14.0 6.8 19.2 11.0 20.9 17.0 27.5 11.9 7.6 9.9 15.8 15.3 17.4 12.2 14.7 45.2 38.8 24.2 26.1 18.0 10.6 11.5 9.4 45.2 8.9 31.9 26.3 25.7 70.3 19.7 32.4 19.9 28.6 19.1 21.6 37.6 26.4 13.6 14.3 13.4 14.2 39.7 34.3 22.3 19.7 33.2 32.6 19.5 33.1 31.3 24.1 31.8 25.4 33.9 25.9 CYP21A2 "CA21H, CAH1, CPS1, CYP21, CYP21B, P450c21B" ENSG00000231852 "Cytochrome P450 family 21 subfamily A member 2" P08686 6 32038265-32041670 "Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins" Steroidogenesis "Monooxygenase, Oxidoreductase" "Congenital adrenal hyperplasia, Disease mutation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 23 "adrenal gland: 170.9" "Cell line enhanced" "Detected in some" "HDLM-2: 11.5;Hep G2: 1.8;Karpas-707: 3.1" "Cancer enhanced" "Detected in some" "liver cancer: 2.7" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in many" "HPA048979, HPA053371" Enhanced "Intracellular and membrane" "HPA048979: AB_2680584, HPA053371: AB_2682131" "unprognostic (1.03e-2)" "unprognostic (1.65e-1)" "unprognostic (1.02e-4)" "unprognostic (2.58e-1)" "unprognostic (2.97e-1)" "unprognostic (2.93e-2)" "unprognostic (2.76e-2)" "unprognostic (8.75e-2)" "unprognostic (1.39e-1)" "unprognostic (1.71e-1)" "unprognostic (1.41e-1)" "unprognostic (1.93e-1)" "unprognostic (6.67e-7)" "unprognostic (7.39e-2)" "unprognostic (5.24e-2)" "unprognostic (1.09e-1)" "unprognostic (1.82e-1)" 0.1 170.9 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.1 0.1 6.7 0.1 0.0 0.1 0.2 0.1 0.0 0.1 0.1 0.1 0.0 0.3 7.4 0.1 0.1 0.1 0.1 0.2 0.1 0.0 0.1 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.1 0.0 0.1 0.1 0.1 3.6 0.0 0.4 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 11.5 0.3 0.0 0.0 1.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.4 1.1 0.0 0.0 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.1 CYP27A1 "CP27, CTX, CYP27" ENSG00000135929 "Cytochrome P450 family 27 subfamily A member 1" Q02318 2 218781749-218815293 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" "Cholesterol metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol metabolism" "Monooxygenase, Oxidoreductase" "Cataract, Disease mutation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "liver: 149.0" "Cell line enhanced" "Detected in some" "Hep G2: 72.6;HSkMC: 13.9;RPTEC TERT1: 18.5;SK-MEL-30: 29.8;WM-115: 11.6" "Cancer enhanced" "Detected in all" "liver cancer: 176.9" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 8 "classical monocyte: 38.2;neutrophil: 30.6" "Group enriched" "Detected in many" 20 "granulocytes: 30.6;monocytes: 38.2" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA059155 Enhanced Supported Mitochondria Mitochondria "HPA059155: " "prognostic favourable (1.05e-4)" "unprognostic (4.21e-2)" "unprognostic (2.34e-1)" "unprognostic (1.83e-3)" "unprognostic (3.71e-3)" "unprognostic (1.31e-2)" "prognostic favourable (8.62e-6)" "unprognostic (6.04e-2)" "unprognostic (1.73e-1)" "unprognostic (4.04e-1)" "unprognostic (1.25e-3)" "unprognostic (8.76e-3)" "unprognostic (1.09e-3)" "unprognostic (1.08e-1)" "unprognostic (7.51e-2)" "unprognostic (1.64e-1)" "unprognostic (1.36e-1)" 14.4 12.3 6.3 4.7 13.4 0.7 5.5 2.4 7.5 6.5 21.9 16.9 24.9 21.0 5.0 5.4 3.5 9.2 5.1 6.9 8.3 6.2 12.6 149.0 22.4 5.6 19.9 5.7 9.5 2.4 6.3 7.1 2.0 12.1 11.6 6.0 15.1 10.0 21.5 10.0 3.9 36.8 5.0 18.8 3.1 3.5 3.7 15.7 3.7 3.1 4.0 7.6 5.5 5.7 0.1 1.7 30.6 38.2 0.0 0.1 10.0 0.0 0.0 0.7 0.0 1.3 0.8 0.1 0.8 3.0 1.0 2.1 3.6 0.1 0.0 1.5 2.0 0.0 0.0 0.0 0.4 0.3 0.3 0.0 0.1 72.6 4.2 0.1 0.0 13.9 0.1 0.0 0.0 1.4 0.0 0.0 2.0 0.0 0.0 0.1 0.8 0.1 0.0 0.7 0.1 18.5 0.0 0.0 0.0 0.0 0.0 29.8 0.5 0.7 1.6 0.0 0.1 0.0 1.8 0.0 0.0 0.0 0.0 0.0 11.6 0.0 38.2 0.1 0.0 4.3 0.0 0.1 0.0 0.1 1.7 0.0 0.0 0.0 30.6 0.0 0.3 0.2 0.0 10.0 6.3 13.4 2.4 7.5 8.3 6.2 19.9 5.7 12.1 15.7 CYP2E1 CYP2E ENSG00000130649 "Cytochrome P450 family 2 subfamily E member 1" P05181 10 133520406-133561220 "Cancer-related genes, Enzymes, Predicted intracellular proteins" "Fatty acid metabolism, Lipid metabolism" "Monooxygenase, Oxidoreductase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 87 "liver: 802.4" "Cell line enhanced" "Detected in many" "HaCaT: 9.6;HL-60: 7.4;HMC-1: 7.9;NB-4: 20.2" "Cancer enriched" "Detected in some" 278 "liver cancer: 265.3" "Not detected" "Not detected" "Cell type enhanced" "Detected in some" "MAIT T-cell: 3.9;myeloid DC: 9.1" "Group enriched" "Detected in many" 17 "dendritic cells: 9.1;T-cells: 3.9" "Not detected" "Not detected" "Low region specificity" "Detected in all" "HPA009128, HPA029564" Enhanced "Intracellular and membrane" "HPA009128: AB_1078613, HPA029564: AB_10602213" "unprognostic (6.32e-2)" "unprognostic (1.51e-2)" "unprognostic (3.83e-5)" "unprognostic (1.27e-1)" "unprognostic (3.37e-2)" "unprognostic (1.26e-1)" "unprognostic (2.92e-3)" "unprognostic (6.36e-3)" "unprognostic (2.41e-2)" "unprognostic (1.49e-1)" "unprognostic (1.63e-1)" "unprognostic (3.21e-2)" "unprognostic (1.70e-4)" "unprognostic (1.72e-1)" "unprognostic (8.36e-2)" "unprognostic (3.78e-1)" "unprognostic (9.59e-2)" 0.1 0.0 0.1 0.1 0.2 0.0 0.1 0.6 0.3 0.1 0.1 0.2 0.7 0.0 0.1 0.3 0.8 0.2 1.3 0.1 0.1 0.1 0.3 802.4 0.1 0.1 0.1 0.1 0.1 0.4 0.0 0.1 0.1 0.3 0.1 0.0 0.2 0.1 1.1 0.1 0.6 0.1 0.1 0.1 0.4 0.1 0.3 0.1 0.1 0.2 0.2 1.5 0.1 0.1 0.0 9.1 0.0 0.3 0.2 3.9 0.3 0.1 0.0 0.3 0.9 3.2 1.8 0.6 1.4 3.9 0.0 0.3 0.0 2.3 1.2 0.2 0.4 9.6 0.0 0.2 0.3 0.2 1.3 1.5 0.1 1.1 0.5 7.4 7.9 0.9 0.2 0.0 0.6 0.0 0.4 0.3 0.9 0.6 0.5 20.2 5.5 0.3 0.3 5.4 0.0 1.7 0.0 0.0 0.0 3.7 0.0 0.6 0.2 0.8 0.0 1.2 0.4 2.0 0.9 2.0 0.8 2.7 1.3 6.3 0.1 0.0 0.0 0.0 0.1 0.0 3.9 0.0 1.7 1.0 9.1 0.0 0.1 0.0 0.0 0.2 0.3 0.1 0.0 0.3 0.1 0.2 0.6 0.3 0.1 0.1 0.1 0.1 0.3 0.1 CYP3A4 CYP3A3 ENSG00000160868 "Cytochrome P450 family 3 subfamily A member 4" P08684 7 99756960-99784265 "Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol metabolism" "Monooxygenase, Oxidoreductase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 45 "intestine: 145.3;liver: 464.6" "Cell line enhanced" "Detected in some" "BEWO: 4.1;NB-4: 4.4;RPMI-8226: 6.6;SCLC-21H: 2.5;SH-SY5Y: 4.9" "Cancer enriched" "Detected in some" 240 "liver cancer: 351.3" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "CAB033671, HPA072245" Enhanced Uncertain Cytosol Cytosol "CAB033671: AB_782375, HPA072245: " "unprognostic (4.55e-2)" "unprognostic (8.95e-2)" "unprognostic (8.08e-2)" "unprognostic (1.63e-1)" "unprognostic (5.89e-2)" "unprognostic (5.37e-2)" "unprognostic (7.07e-3)" "unprognostic (9.09e-2)" "unprognostic (8.27e-3)" "unprognostic (4.92e-2)" "unprognostic (3.78e-2)" "unprognostic (6.42e-2)" "unprognostic (1.89e-8)" "unprognostic (2.59e-1)" "unprognostic (1.75e-2)" "unprognostic (9.79e-2)" "unprognostic (6.82e-2)" 0.1 0.4 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.1 145.3 0.1 0.1 56.0 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.0 0.2 464.6 0.1 0.1 0.1 0.1 0.1 6.8 0.0 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.3 0.2 126.7 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.4 0.2 0.6 0.2 0.6 0.2 0.2 0.0 0.1 0.0 0.0 0.0 0.0 4.1 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 1.3 0.1 0.2 0.0 1.9 0.4 0.0 1.2 0.0 0.4 0.0 0.5 0.0 0.5 0.0 0.1 4.4 0.3 0.0 0.0 2.1 6.6 0.0 0.4 2.5 4.9 0.4 0.0 0.0 0.1 0.0 0.8 0.0 0.0 1.3 0.0 0.7 0.0 0.7 0.1 0.7 0.1 0.3 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.4 0.1 0.2 0.6 0.6 0.0 0.2 0.2 0.2 0.1 0.1 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.1 DLD "DLDH, GCSL, LAD" ENSG00000091140 "Dihydrolipoamide dehydrogenase" P09622 7 107890970-107931730 "Citric acid cycle related proteins, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins" Oxidoreductase "Disease mutation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA044849 Supported Supported Mitochondria 16000000 Mitochondria "HPA044849: " "unprognostic (2.01e-3)" "unprognostic (2.26e-1)" "unprognostic (1.27e-2)" "unprognostic (9.27e-2)" "unprognostic (5.01e-3)" "unprognostic (9.27e-2)" "unprognostic (2.48e-1)" "unprognostic (2.83e-2)" "unprognostic (1.19e-1)" "unprognostic (3.95e-2)" "unprognostic (9.43e-2)" "unprognostic (7.35e-2)" "prognostic favourable (7.58e-9)" "unprognostic (4.08e-2)" "unprognostic (1.88e-1)" "unprognostic (4.45e-3)" "unprognostic (1.18e-1)" 25.7 37.9 14.5 12.7 25.4 12.0 15.2 16.6 27.2 13.2 28.0 10.6 12.2 20.9 13.6 9.6 25.6 11.6 12.7 69.1 16.4 14.4 40.7 37.9 11.0 13.0 16.7 20.1 15.1 14.8 24.6 22.4 15.4 29.3 14.7 26.8 12.8 19.4 14.4 71.5 13.8 29.5 23.7 10.6 17.4 23.0 10.6 10.7 18.7 17.0 31.8 16.9 20.1 11.7 13.5 30.4 45.8 37.8 22.9 19.4 20.2 39.9 32.4 18.0 31.0 25.9 22.9 20.4 23.0 19.4 26.8 20.8 37.9 22.4 39.1 39.7 24.4 26.6 36.2 32.4 40.5 26.1 21.5 27.5 43.0 27.0 19.9 45.2 28.4 26.1 23.6 28.4 15.5 32.1 68.6 29.2 29.0 44.9 36.9 32.8 21.4 23.5 26.6 28.8 53.0 36.6 59.8 22.4 23.7 37.7 63.7 33.8 24.2 38.7 20.3 29.6 24.3 57.6 34.9 22.1 42.1 26.3 27.9 48.3 30.6 36.5 22.3 45.8 17.5 28.2 18.5 13.5 17.7 17.3 30.4 12.3 18.7 19.4 14.0 22.9 37.8 10.5 16.8 20.2 14.5 25.4 16.6 27.2 16.4 14.4 16.7 20.1 29.3 10.7 EPX "EPO, EPP, EPX-PEN" ENSG00000121053 "Eosinophil peroxidase" P11678 17 58192737-58205174 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" "Hydrogen peroxide" "Oxidoreductase, Peroxidase" "Disease mutation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "bone marrow: 27.2;lymphoid tissue: 15.5" "Cell line enriched" "Detected in some" 69 "NB-4: 72.6" "Not detected" "Not detected" "Low region specificity" "Detected in single" "Cell type enriched" "Detected in single" 41 "eosinophil: 5.5" "Lineage enriched" "Detected in single" 41 "granulocytes: 5.5" "Low region specificity" "Detected in some" "Not detected" "Not detected" HPA076792 Enhanced "HPA076792: " "unprognostic (5.67e-2)" "unprognostic (1.73e-2)" "unprognostic (3.36e-2)" "unprognostic (3.30e-1)" "unprognostic (2.18e-1)" "unprognostic (1.34e-3)" "unprognostic (4.83e-1)" "unprognostic (3.16e-2)" "unprognostic (1.41e-1)" "unprognostic (1.52e-2)" "unprognostic (1.71e-4)" "unprognostic (7.38e-2)" "unprognostic (1.64e-1)" "unprognostic (2.02e-1)" "unprognostic (5.43e-2)" "unprognostic (1.02e-2)" "unprognostic (1.73e-1)" 0.1 0.1 0.3 0.2 0.8 27.2 0.1 2.0 0.6 0.1 0.1 0.5 0.1 0.1 0.4 0.1 0.1 0.2 0.1 1.4 0.3 0.3 0.1 0.2 4.2 0.4 0.2 0.1 0.2 0.1 0.0 0.3 0.2 0.6 0.1 0.0 0.1 0.3 0.1 0.1 0.5 0.1 0.1 0.2 4.5 0.1 0.1 0.1 15.5 0.1 0.1 0.1 0.1 0.1 0.0 0.0 5.5 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 1.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 72.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 5.5 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.8 2.0 0.6 0.3 0.3 0.2 0.1 0.6 0.1 FDXR ADXR ENSG00000161513 "Ferredoxin reductase" P22570 17 74862497-74873031 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" "Cholesterol metabolism, Electron transport, Lipid metabolism, Steroid metabolism, Sterol metabolism, Transport" Oxidoreductase "Deafness, Disease mutation, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "adrenal gland: 93.9" "Cell line enhanced" "Detected in many" "BEWO: 29.5;Hep G2: 54.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB008597, CAB009818, HPA044393, HPA053673" Enhanced Enhanced Mitochondria Mitochondria "CAB008597: AB_1615557, CAB009818: AB_2102601, HPA044393: AB_2678927, HPA053673: AB_2682225" "unprognostic (2.69e-2)" "unprognostic (1.17e-3)" "unprognostic (7.51e-2)" "prognostic favourable (2.38e-4)" "unprognostic (3.43e-2)" "unprognostic (1.20e-1)" "unprognostic (1.53e-1)" "unprognostic (1.68e-2)" "unprognostic (2.29e-1)" "unprognostic (1.50e-1)" "unprognostic (1.09e-1)" "unprognostic (6.30e-2)" "unprognostic (1.42e-2)" "unprognostic (1.19e-2)" "unprognostic (4.50e-2)" "unprognostic (4.03e-2)" "unprognostic (2.13e-1)" 1.7 93.9 2.6 2.1 3.1 1.3 1.8 8.4 2.7 2.1 4.6 3.2 6.4 2.6 2.6 23.8 8.7 6.6 6.1 1.9 3.4 1.7 2.7 4.1 4.4 1.7 2.9 3.5 7.1 3.9 2.3 1.5 2.6 3.6 3.3 2.1 0.9 5.3 4.2 7.9 5.6 2.5 2.0 4.4 9.7 2.2 32.1 3.0 3.9 2.0 7.7 3.7 3.0 3.0 5.4 7.4 4.8 6.4 10.0 15.2 5.6 3.9 21.1 3.1 3.5 2.3 3.0 29.5 4.7 5.2 2.8 5.7 5.9 3.5 9.4 0.8 2.0 8.1 2.3 5.9 0.8 8.9 4.9 7.1 3.5 54.0 6.4 1.5 25.0 9.9 6.7 2.9 1.0 14.4 11.3 1.5 4.3 16.7 6.1 3.3 1.7 4.6 3.3 5.3 5.0 2.3 6.7 1.7 4.0 3.2 7.1 3.4 15.4 1.5 6.7 1.9 17.6 3.1 2.3 4.4 0.7 2.0 5.3 2.4 6.6 1.8 6.4 4.8 6.2 4.3 5.3 5.4 5.6 7.3 7.4 2.8 4.9 6.1 2.1 10.0 3.2 1.4 15.2 5.6 2.6 3.1 8.4 2.7 3.4 1.7 2.9 3.5 3.6 3.0 GLB1 "EBP, ELNR1" ENSG00000170266 "Galactosidase beta 1" P16278 3 32996608-33097230 "Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Glycosidase, Hydrolase" "Disease mutation, Gangliosidosis, Mucopolysaccharidosis" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell line enhanced" "Detected in many" "BEWO: 136.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB008382, HPA040610, HPA069503" Enhanced Supported "Golgi apparatus,Vesicles" "Intracellular and membrane" 1700000 Vesicles "Golgi apparatus" "CAB008382: AB_590642, HPA040610: , HPA069503: " "unprognostic (1.51e-2)" "unprognostic (3.66e-2)" "unprognostic (5.02e-3)" "unprognostic (9.66e-3)" "unprognostic (9.61e-3)" "unprognostic (1.04e-1)" "unprognostic (2.31e-3)" "unprognostic (1.32e-1)" "unprognostic (2.08e-1)" "unprognostic (1.16e-1)" "unprognostic (2.06e-1)" "unprognostic (2.08e-1)" "prognostic favourable (1.14e-5)" "unprognostic (3.05e-1)" "unprognostic (2.33e-1)" "unprognostic (2.20e-1)" "unprognostic (5.85e-2)" 17.3 33.1 9.6 14.9 14.7 9.5 18.4 8.9 19.8 18.3 21.9 12.1 19.8 21.2 18.3 55.0 12.7 15.2 25.8 13.7 9.7 10.0 35.0 33.2 24.3 25.0 9.2 9.7 18.3 25.3 28.4 16.4 26.5 14.0 13.6 23.7 23.5 21.1 17.7 6.1 12.9 28.3 15.6 9.8 21.4 22.7 10.0 8.0 8.3 26.9 7.7 19.5 18.4 13.6 11.1 45.2 22.7 39.2 6.8 20.9 20.9 5.6 9.8 6.3 7.6 39.1 20.3 136.7 9.1 24.7 11.7 15.1 13.9 13.6 2.8 8.1 18.6 5.5 6.0 11.6 8.7 16.0 5.0 10.9 5.9 7.1 20.1 7.6 11.2 23.4 11.2 10.6 6.3 18.0 9.8 10.6 12.8 6.6 4.5 5.0 4.3 4.3 3.9 4.2 13.0 12.6 8.4 1.9 6.6 11.7 19.0 11.4 12.6 19.9 10.5 7.5 5.2 10.3 7.7 8.4 13.4 0.9 15.9 11.0 5.7 10.5 39.2 22.7 8.3 34.6 11.8 11.1 10.2 9.1 45.2 10.0 5.4 6.5 15.5 6.8 23.7 9.5 20.9 20.9 9.6 14.7 8.9 19.8 9.7 10.0 9.2 9.7 14.0 8.0 GPAT3 "AGPAT10, AGPAT9, HMFN0839, LPAAT-theta, MAG1, MGC11324" ENSG00000138678 "Glycerol-3-phosphate acyltransferase 3" Q53EU6 4 83535914-83605875 "Enzymes, Predicted membrane proteins" "Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 47.2;kidney: 43.7" "Cell line enhanced" "Detected in many" "CAPAN-2: 54.5;HMC-1: 20.0;U-87 MG: 23.8;WM-115: 18.2" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Cell type enhanced" "Detected in many" "basophil: 42.0" "Low lineage specificity" "Detected in many" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" "HPA029414, CAB033749" Approved Uncertain "Plasma membrane,Cytosol" "Plasma membrane, Cytosol" "CAB033749: AB_2224941, HPA029414: AB_10601562" "unprognostic (9.51e-2)" "unprognostic (1.43e-2)" "unprognostic (5.67e-2)" "unprognostic (1.70e-1)" "unprognostic (3.50e-3)" "unprognostic (2.61e-2)" "unprognostic (2.05e-1)" "unprognostic (1.25e-1)" "unprognostic (1.09e-2)" "unprognostic (4.30e-2)" "unprognostic (1.12e-1)" "unprognostic (2.92e-1)" "prognostic favourable (2.71e-9)" "unprognostic (3.74e-1)" "unprognostic (3.45e-2)" "unprognostic (2.53e-3)" "prognostic unfavourable (8.21e-4)" 7.9 0.7 0.7 5.2 1.4 5.2 17.5 4.2 2.9 3.7 18.0 1.2 1.3 20.2 3.0 2.1 5.1 2.1 6.0 24.8 1.2 2.2 43.7 9.0 3.2 4.5 1.9 0.8 12.9 1.7 11.8 5.8 1.2 9.5 2.6 5.7 1.3 3.6 1.9 35.9 1.9 47.2 3.7 3.0 4.3 7.4 4.6 1.4 0.9 26.6 14.6 3.4 4.5 7.2 0.0 23.2 42.0 9.7 0.5 1.8 2.9 10.4 10.3 0.0 0.1 0.5 1.3 0.2 0.8 1.5 0.2 0.2 0.7 54.5 0.0 1.1 2.0 2.3 4.9 0.9 0.1 0.7 2.3 0.0 3.2 10.0 1.4 2.9 20.0 0.7 0.0 0.4 1.2 5.1 8.3 8.2 0.2 1.0 0.7 0.7 0.2 4.4 0.1 2.3 3.9 10.3 0.7 0.2 0.0 2.0 2.1 5.7 0.4 0.5 0.2 2.5 4.4 2.4 9.8 0.4 0.7 0.0 23.8 5.9 18.2 42.0 9.7 1.0 0.2 7.7 1.8 0.0 1.0 0.6 23.2 0.0 0.7 0.3 26.4 0.5 6.1 0.1 0.6 2.9 0.7 1.4 4.2 2.9 1.2 2.2 1.9 0.8 9.5 1.4 GPAT4 "AGPAT6, DKFZp586M1819, LPAAT-zeta, TSARG7" ENSG00000158669 "Glycerol-3-phosphate acyltransferase 4" Q86UL3 8 41577187-41625001 "Enzymes, Predicted membrane proteins" "Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA016471 Approved "HPA016471: AB_1844649" "unprognostic (3.05e-2)" "unprognostic (4.05e-2)" "unprognostic (4.24e-2)" "prognostic unfavourable (9.37e-4)" "unprognostic (7.45e-2)" "unprognostic (2.99e-3)" "unprognostic (5.08e-2)" "unprognostic (5.11e-2)" "unprognostic (3.79e-2)" "prognostic unfavourable (2.20e-4)" "unprognostic (1.98e-2)" "prognostic favourable (4.15e-4)" "unprognostic (1.73e-3)" "unprognostic (3.16e-2)" "unprognostic (3.35e-1)" "unprognostic (2.04e-2)" "prognostic favourable (5.65e-4)" 15.7 27.4 14.4 17.8 17.2 16.6 28.1 43.8 21.9 16.9 14.0 23.1 22.7 13.0 22.8 12.0 13.1 14.6 15.8 14.1 14.0 13.1 20.8 26.7 18.7 13.8 18.5 13.6 16.6 17.3 35.7 22.3 23.3 20.5 15.1 15.1 21.0 20.8 15.5 42.1 14.5 14.6 23.0 18.0 17.5 17.8 15.5 16.6 15.2 14.5 12.4 19.4 16.6 14.9 9.1 18.9 10.8 15.0 4.9 12.1 11.1 14.6 16.3 19.5 15.2 21.4 26.0 17.2 31.9 27.5 24.2 25.3 10.9 29.5 20.4 22.4 26.3 8.5 22.8 14.4 31.4 21.8 12.5 23.8 18.1 10.0 12.5 2.5 34.4 16.3 10.6 25.2 9.1 24.8 17.7 24.1 24.8 6.2 22.2 6.5 20.8 8.7 13.0 19.5 11.0 14.7 22.0 12.8 17.7 12.4 17.1 34.2 23.7 16.1 18.1 25.1 17.6 28.7 23.8 13.0 17.4 22.3 20.6 14.1 24.5 10.8 15.0 6.6 12.1 14.3 11.3 8.3 9.3 11.9 18.9 9.1 8.5 8.2 3.5 4.9 12.0 7.1 8.7 11.1 14.4 17.2 43.8 21.9 14.0 13.1 18.5 13.6 20.5 16.6 GUSB ENSG00000169919 "Glucuronidase beta" P08236 7 65960684-65982314 "Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Glycosidase, Hydrolase" "Cancer-related genes, Disease mutation, Mucopolysaccharidosis" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell line enhanced" "Detected in all" "Karpas-707: 55.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA036322, HPA036323" Approved Supported Vesicles "Intracellular and membrane" 48000 Vesicles "HPA036322: AB_10670796, HPA036323: " "unprognostic (1.54e-2)" "unprognostic (6.49e-2)" "unprognostic (1.18e-2)" "unprognostic (3.50e-1)" "unprognostic (2.58e-2)" "unprognostic (4.46e-2)" "unprognostic (2.89e-1)" "unprognostic (1.56e-3)" "unprognostic (1.32e-1)" "unprognostic (2.32e-1)" "unprognostic (7.00e-3)" "unprognostic (1.91e-1)" "unprognostic (3.34e-2)" "unprognostic (8.83e-3)" "unprognostic (1.98e-1)" "unprognostic (5.06e-1)" "unprognostic (1.45e-1)" 23.5 12.0 3.7 7.9 5.5 20.7 25.4 5.7 4.4 10.4 14.6 7.7 22.0 10.0 10.4 12.2 9.3 7.6 11.1 8.0 3.7 2.9 11.8 50.4 15.3 12.3 6.3 3.1 8.6 17.1 9.0 7.3 30.0 4.5 12.1 11.4 9.9 17.2 11.8 5.9 10.0 16.1 8.3 3.9 17.5 11.0 7.9 5.8 14.7 17.7 5.9 13.0 9.2 7.4 9.7 27.7 22.1 36.0 15.2 11.5 15.8 16.8 6.5 6.4 14.3 21.9 13.1 9.3 5.3 14.9 11.8 10.9 9.3 17.4 7.7 8.4 6.8 6.9 4.1 6.4 7.0 7.2 8.4 10.5 9.8 6.4 10.7 22.4 17.5 9.0 6.9 6.8 8.9 10.2 15.9 55.9 7.6 12.2 8.2 24.1 4.3 5.5 8.5 14.8 43.7 7.4 10.2 9.4 8.3 14.3 33.6 18.7 18.7 22.4 7.2 14.4 13.1 5.4 13.3 31.8 38.1 13.0 10.8 29.9 17.5 7.4 28.1 22.1 11.5 36.0 10.3 9.7 9.0 10.2 27.7 7.8 6.2 7.3 4.5 15.2 30.0 11.3 11.3 15.8 3.7 5.5 5.7 4.4 3.7 2.9 6.3 3.1 4.5 5.8 HADHB MTPB ENSG00000138029 "Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta" P55084 2 26243170-26290468 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" "Fatty acid metabolism, Lipid metabolism" "Acyltransferase, Transferase" "Disease mutation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "heart muscle: 126.0;skeletal muscle: 155.6" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA037539, HPA037540, HPA066099" Enhanced Supported Mitochondria 1100000 Mitochondria "HPA037539: AB_10671374, HPA037540: AB_2675531, HPA066099: AB_2685618" "unprognostic (5.15e-2)" "unprognostic (8.72e-2)" "unprognostic (8.21e-2)" "unprognostic (8.67e-2)" "unprognostic (7.70e-2)" "unprognostic (2.59e-2)" "unprognostic (7.29e-2)" "unprognostic (9.70e-2)" "unprognostic (2.01e-1)" "unprognostic (2.09e-1)" "unprognostic (2.03e-1)" "unprognostic (8.94e-2)" "prognostic favourable (1.37e-9)" "unprognostic (2.47e-1)" "unprognostic (2.50e-1)" "unprognostic (2.88e-1)" "unprognostic (9.68e-2)" 23.3 45.5 24.8 11.0 24.7 9.9 16.6 16.6 17.4 13.8 21.4 31.1 19.3 43.6 17.1 16.2 20.6 13.9 12.6 126.0 18.0 20.0 45.8 62.4 12.8 16.1 34.8 18.3 16.2 23.7 19.9 13.1 12.6 27.8 15.8 22.8 19.9 27.2 15.9 155.6 13.2 35.0 20.3 29.5 15.3 19.5 15.8 23.8 10.6 22.4 44.9 14.5 18.5 12.8 20.2 45.2 21.5 49.1 23.8 26.8 33.9 22.7 18.0 12.6 22.5 77.7 43.0 12.7 19.2 29.4 19.8 19.4 21.5 22.2 11.4 13.5 31.4 18.0 20.9 27.1 24.3 25.7 18.2 26.2 10.7 42.0 33.3 21.1 20.1 41.6 44.8 20.5 33.5 36.6 21.9 18.5 41.2 16.7 11.8 40.8 8.7 19.6 13.1 41.6 21.7 40.7 32.4 6.0 20.7 32.9 37.5 50.4 23.2 37.8 25.3 18.7 19.5 17.5 13.8 13.9 20.9 20.1 21.5 33.8 18.5 21.0 49.1 18.9 14.2 43.4 18.1 20.2 19.3 17.6 45.2 14.8 18.0 16.3 21.5 23.8 33.2 15.3 26.8 33.9 24.8 24.7 16.6 17.4 18.0 20.0 34.8 18.3 27.8 23.8 HSD17B7 "PRAP, SDR37C1" ENSG00000132196 "Hydroxysteroid 17-beta dehydrogenase 7" P56937 1 162790702-162812817 "Enzymes, Predicted intracellular proteins, Predicted membrane proteins" "Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis" Oxidoreductase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "blood: 16.3;liver: 16.8" "Low cell line specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA047496 Approved "HPA047496: " "unprognostic (2.93e-1)" "unprognostic (1.36e-2)" "unprognostic (6.03e-2)" "unprognostic (1.12e-1)" "unprognostic (2.34e-1)" "unprognostic (1.63e-3)" "unprognostic (2.57e-1)" "unprognostic (2.51e-2)" "unprognostic (1.36e-1)" "unprognostic (1.38e-1)" "unprognostic (1.94e-1)" "unprognostic (1.37e-1)" "prognostic unfavourable (8.47e-5)" "unprognostic (6.25e-2)" "unprognostic (1.90e-1)" "unprognostic (6.35e-2)" "unprognostic (3.17e-2)" 1.9 9.2 1.4 2.0 1.0 0.7 4.3 1.4 1.9 2.8 2.9 3.1 2.1 4.4 4.7 2.2 1.6 1.6 1.9 2.6 2.2 16.8 4.3 3.7 1.5 3.6 2.6 2.5 4.1 1.8 2.8 4.0 3.1 1.3 2.0 3.6 3.1 1.8 3.2 2.9 2.9 0.6 2.8 3.9 2.2 2.8 12.5 9.6 15.8 7.4 7.0 16.3 10.5 6.8 7.0 18.5 8.2 10.7 11.5 12.1 2.7 8.9 5.4 10.8 9.6 22.0 16.4 6.3 2.3 11.0 16.8 23.7 5.7 7.1 9.0 4.1 5.3 15.1 8.9 7.3 7.3 6.9 13.2 21.0 6.9 8.9 7.8 11.3 4.6 4.8 9.5 7.9 11.7 8.7 5.3 11.1 10.5 19.2 10.9 15.8 8.2 4.4 4.3 4.2 7.0 9.4 5.3 2.5 5.9 3.8 5.3 6.9 6.8 16.2 4.0 0.6 6.1 15.8 6.0 11.2 13.9 6.1 14.6 12.5 10.5 13.4 6.5 10.9 13.0 13.1 5.0 7.0 7.4 9.6 16.3 10.5 KL ENSG00000133116 Klotho Q9UEF7 13 33016433-33066145 "Disease related genes, Enzymes, Potential drug targets, Predicted membrane proteins, Predicted secreted proteins, Transporters" "Glycosidase, Hormone, Hydrolase" "Disease mutation" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 5 "kidney: 64.3;parathyroid gland: 76.9;placenta: 25.5" "Group enriched" "Detected in some" 5 "HMC-1: 5.0;SK-BR-3: 9.4" "Group enriched" "Detected in many" 6 "prostate cancer: 5.9;renal cancer: 17.8" "Region enhanced" "Detected in some" "pons and medulla: 11.6" "Cell type enhanced" "Detected in single" "classical monocyte: 1.0" "Low lineage specificity" "Detected in single" "Low region specificity" "Detected in many" "Secreted to blood" 510400 "unprognostic (1.32e-1)" "unprognostic (3.10e-1)" "unprognostic (2.35e-1)" "unprognostic (2.73e-3)" "unprognostic (3.37e-1)" "unprognostic (1.15e-4)" "unprognostic (3.06e-2)" "unprognostic (6.50e-2)" "unprognostic (2.22e-2)" "unprognostic (2.60e-1)" "prognostic favourable (4.44e-4)" "unprognostic (9.46e-2)" "prognostic favourable (1.29e-9)" "unprognostic (4.76e-3)" "unprognostic (1.91e-1)" "unprognostic (2.86e-2)" "unprognostic (1.07e-1)" 4.8 0.6 0.8 0.9 4.3 0.1 7.4 0.0 0.8 0.7 2.1 3.3 0.2 1.0 1.0 3.2 0.8 0.7 0.9 0.9 2.4 0.8 64.3 0.2 10.4 0.9 0.5 0.3 0.4 1.6 76.9 0.3 25.5 11.6 3.3 0.4 0.3 0.7 1.0 0.9 0.4 3.2 0.7 0.4 3.1 1.9 0.6 0.3 0.0 1.4 1.3 0.3 1.5 1.1 0.0 0.0 0.0 1.0 0.3 0.6 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.5 0.0 0.0 0.1 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 9.4 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.3 0.0 0.0 0.0 0.1 0.8 4.3 0.0 0.8 2.4 0.8 0.5 0.3 11.6 0.3 LHPP HDHD2B ENSG00000107902 "Phospholysine phosphohistidine inorganic pyrophosphate phosphatase" Q9H008 10 124461834-124617888 "Enzymes, Predicted intracellular proteins" Hydrolase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 106.0" "Low cell line specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA009163, HPA009269" Enhanced Supported "Nuclear speckles,Cytosol" 880000 "Nuclear speckles, Cytosol" "HPA009163: AB_1079250, HPA009269: AB_1079249" "unprognostic (3.46e-2)" "unprognostic (1.23e-2)" "unprognostic (4.78e-2)" "unprognostic (3.89e-1)" "unprognostic (2.14e-1)" "unprognostic (1.96e-1)" "unprognostic (5.77e-3)" "unprognostic (2.02e-2)" "unprognostic (3.58e-1)" "unprognostic (1.93e-1)" "unprognostic (6.42e-2)" "unprognostic (5.55e-2)" "unprognostic (1.79e-3)" "unprognostic (2.52e-1)" "unprognostic (2.10e-1)" "unprognostic (1.98e-1)" "unprognostic (1.64e-1)" 9.6 14.2 37.3 6.0 34.0 6.9 7.9 11.9 34.2 12.3 13.6 29.7 8.2 17.9 7.5 11.0 12.7 8.1 8.3 9.8 43.0 31.5 18.6 33.8 6.6 8.2 62.7 19.3 5.5 12.2 6.6 5.6 7.2 20.5 6.9 6.7 6.7 13.3 10.6 6.5 8.9 15.7 8.1 106.0 8.2 12.4 14.2 19.5 7.1 20.5 3.6 11.2 8.7 5.7 24.7 20.0 13.3 16.1 3.9 17.2 12.9 14.7 7.3 3.0 7.5 11.6 9.5 7.9 5.4 11.1 3.4 6.3 1.3 13.7 14.6 12.6 8.1 16.0 0.9 2.8 3.6 3.2 10.5 10.6 2.3 6.7 11.8 2.1 17.3 7.0 12.5 3.4 8.2 5.4 5.2 5.8 4.2 14.6 7.0 6.8 5.3 4.1 7.5 3.3 18.6 7.4 1.9 1.6 9.0 3.8 13.9 4.9 10.5 0.3 2.5 5.3 7.9 4.4 1.4 4.9 1.5 4.7 4.9 4.1 1.2 4.6 16.1 13.3 9.5 13.5 12.4 23.7 11.1 10.1 20.0 24.7 13.7 9.6 2.7 3.9 14.9 7.5 17.2 12.9 37.3 34.0 11.9 25.0 43.0 31.5 62.7 19.3 20.5 19.5 LPO SPO ENSG00000167419 Lactoperoxidase P22079 17 58218548-58268518 "Enzymes, Predicted intracellular proteins, Predicted secreted proteins" "Hydrogen peroxide" "Antimicrobial, Oxidoreductase, Peroxidase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 262 "salivary gland: 345.7" "Cell line enriched" "Detected in some" 9 "THP-1: 14.1" "Not detected" "Not detected" "Not detected" "Not detected" "Low cell type specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA028688 Enhanced Supported "Secreted to digestive system" "HPA028688: AB_10601909" "unprognostic (2.74e-1)" "unprognostic (5.12e-2)" "unprognostic (4.14e-3)" "unprognostic (1.56e-3)" "unprognostic (2.41e-2)" "unprognostic (9.71e-2)" "unprognostic (2.06e-2)" "unprognostic (1.53e-1)" "unprognostic (2.40e-2)" "unprognostic (6.27e-3)" "unprognostic (6.32e-2)" "unprognostic (2.56e-1)" "unprognostic (0.00e+0)" "unprognostic (3.41e-2)" "unprognostic (3.15e-1)" "unprognostic (2.72e-2)" "unprognostic (1.22e-1)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.8 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 345.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.3 1.2 0.0 0.0 1.2 0.8 1.3 0.7 0.8 0.9 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.6 0.0 0.0 0.0 0.0 0.1 0.0 0.1 1.1 0.0 0.0 0.0 0.0 0.0 14.1 0.0 0.1 0.1 0.0 0.0 0.1 0.0 0.0 1.0 1.5 0.0 0.9 0.7 0.4 0.6 0.3 0.5 0.9 0.7 0.6 0.2 1.2 0.6 0.9 1.3 0.8 0.3 0.8 0.4 0.4 0.0 0.0 0.0 0.1 0.1 0.0 0.8 0.0 0.0 0.0 MPO ENSG00000005381 Myeloperoxidase P05164 17 58269856-58280935 "Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Hydrogen peroxide" "Oxidoreductase, Peroxidase" "Cancer-related genes, Disease mutation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 15 "bone marrow: 315.2" "Group enriched" "Detected in some" 93 "HL-60: 212.9;NB-4: 279.1" "Cancer enhanced" "Detected in single" "stomach cancer: 1.1" "Low region specificity" "Detected in single" "Group enriched" "Detected in some" 5 "classical monocyte: 7.6;intermediate monocyte: 3.8;myeloid DC: 3.2;neutrophil: 2.0" "Group enriched" "Detected in many" 30 "dendritic cells: 3.2;granulocytes: 2.0;monocytes: 7.6" "Not detected" "Not detected" "Not detected" "Not detected" "CAB000059, HPA021147, HPA061464" Enhanced Supported Nucleoplasm,Vesicles "Intracellular and membrane" 15000000 Vesicles Nucleoplasm "CAB000059: AB_2335676, HPA021147: AB_1854083, HPA061464: AB_2684531" "unprognostic (1.91e-1)" "unprognostic (9.08e-2)" "unprognostic (4.62e-2)" "unprognostic (2.90e-2)" "unprognostic (2.13e-3)" "unprognostic (2.78e-1)" "unprognostic (3.23e-1)" "unprognostic (2.91e-1)" "unprognostic (2.56e-1)" "unprognostic (1.68e-1)" "unprognostic (6.92e-2)" "unprognostic (8.34e-3)" "unprognostic (4.91e-2)" "unprognostic (3.07e-3)" "unprognostic (2.83e-1)" "unprognostic (1.14e-2)" "unprognostic (8.05e-2)" 0.2 0.1 0.5 0.1 0.8 315.2 0.1 0.4 1.0 0.1 0.1 1.4 0.0 0.1 0.2 0.2 0.1 0.1 0.1 21.5 0.6 0.8 0.1 1.4 6.9 0.8 0.6 0.0 0.6 0.1 0.1 1.0 2.9 0.4 0.2 0.1 0.2 6.3 0.1 0.7 0.5 0.1 0.1 0.4 17.8 0.1 0.4 0.2 19.7 0.6 0.0 0.5 0.1 0.0 0.0 3.2 2.0 7.6 0.0 0.1 7.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 212.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 279.1 0.0 0.0 0.3 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 7.6 0.0 0.0 3.8 0.0 0.0 0.0 0.1 3.2 0.0 0.0 0.0 2.0 0.0 0.8 0.0 0.1 7.2 0.5 0.8 0.4 1.0 0.6 0.8 0.6 0.0 0.4 0.2 NAE1 "APP-BP1, APPBP1, ula-1" ENSG00000159593 "NEDD8 activating enzyme E1 subunit 1" Q13564 16 66802875-66873256 "Plasma proteins, Predicted intracellular proteins" "Apoptosis, Cell cycle, Ubl conjugation pathway" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA041178, HPA042041" Enhanced Approved Nucleoplasm,Microtubules,Centrosome 53000 Nucleoplasm "Microtubules, Centrosome" "HPA041178: AB_10964773, HPA042041: AB_10964772" "unprognostic (3.22e-2)" "unprognostic (1.73e-1)" "unprognostic (1.79e-2)" "unprognostic (1.13e-1)" "unprognostic (2.00e-2)" "unprognostic (1.06e-2)" "prognostic unfavourable (3.92e-8)" "unprognostic (2.31e-1)" "unprognostic (5.58e-2)" "unprognostic (3.12e-3)" "unprognostic (5.34e-2)" "unprognostic (3.85e-2)" "unprognostic (7.09e-3)" "unprognostic (2.50e-1)" "unprognostic (1.84e-1)" "prognostic favourable (9.44e-5)" "unprognostic (1.97e-1)" 23.6 27.4 25.3 20.2 31.8 27.2 27.3 36.7 41.7 26.0 25.8 24.4 23.7 26.2 27.9 31.0 27.5 23.9 20.2 23.6 25.4 29.0 24.3 25.9 18.3 27.0 27.7 31.9 31.0 26.6 38.8 42.2 26.4 34.9 24.9 30.0 22.1 24.3 23.5 33.2 26.9 27.6 25.4 25.3 18.4 22.2 36.9 25.9 28.9 27.9 28.0 24.9 24.7 22.4 9.4 6.4 6.7 3.2 8.6 19.4 9.4 22.6 17.5 31.2 30.7 12.5 17.8 25.9 17.3 17.6 25.7 31.2 21.2 17.6 25.1 19.9 13.0 23.0 23.4 20.8 36.5 9.2 26.7 17.8 12.1 32.9 14.4 33.1 22.4 14.4 15.5 20.4 18.0 17.9 42.1 8.9 19.7 7.9 34.6 37.9 43.2 31.6 37.2 37.2 33.5 19.8 20.0 33.6 24.7 51.8 11.1 19.9 11.9 22.4 13.9 18.0 18.0 18.7 20.0 16.8 25.9 90.5 16.2 22.0 21.7 1.3 3.1 6.7 15.4 3.0 19.4 9.4 16.4 16.6 4.2 7.9 17.8 17.7 1.4 8.6 3.2 6.4 14.0 9.4 25.3 31.8 36.7 41.7 25.4 29.0 27.7 31.9 34.9 25.9 NLN "AGTBP, KIAA1226" ENSG00000123213 Neurolysin Q9BYT8 5 65722196-65871725 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 5 "classical monocyte: 4.7;intermediate monocyte: 5.9;myeloid DC: 4.1;non-classical monocyte: 4.1" "Group enriched" "Detected in many" 5 "dendritic cells: 4.1;monocytes: 5.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA031862 Approved Approved Mitochondria 53000 Mitochondria "HPA031862: AB_10600827" "unprognostic (5.91e-3)" "unprognostic (4.52e-2)" "unprognostic (1.34e-3)" "unprognostic (4.37e-2)" "unprognostic (3.85e-1)" "unprognostic (1.45e-2)" "unprognostic (7.29e-3)" "unprognostic (3.24e-2)" "unprognostic (3.19e-1)" "unprognostic (3.58e-1)" "prognostic unfavourable (7.51e-4)" "unprognostic (1.27e-1)" "prognostic favourable (5.58e-7)" "unprognostic (1.52e-2)" "unprognostic (1.98e-1)" "unprognostic (1.29e-1)" "unprognostic (6.18e-3)" 4.5 2.4 7.6 4.7 10.5 2.9 7.3 2.8 11.9 4.1 6.8 5.8 1.0 2.4 5.8 5.0 5.2 3.3 2.7 5.1 7.2 7.6 7.5 18.9 3.4 5.1 8.7 8.5 4.0 11.0 3.6 2.4 4.9 9.8 5.4 6.5 2.0 4.3 2.6 15.0 5.7 5.3 5.5 10.9 5.8 7.5 2.4 6.2 1.8 5.5 7.9 4.0 4.3 3.3 0.9 4.1 0.6 5.9 0.9 0.7 1.8 9.2 8.9 5.3 8.7 6.6 11.4 10.6 9.3 3.9 5.5 6.0 5.0 5.5 13.2 11.8 11.2 7.4 6.8 14.4 9.6 3.9 4.6 3.6 6.6 12.8 5.7 8.3 2.2 8.7 7.9 7.6 9.1 15.5 7.8 2.8 11.8 7.1 5.7 7.5 16.1 2.5 6.7 11.2 20.8 9.0 4.1 16.3 8.5 7.5 7.8 7.7 9.3 9.9 8.9 3.7 4.4 5.3 7.0 2.4 4.8 5.8 5.6 16.3 5.5 0.2 4.7 0.2 0.2 5.9 0.3 0.9 0.4 0.3 4.1 0.9 0.7 0.5 0.6 0.9 4.1 0.2 0.1 1.8 7.6 10.5 2.8 11.9 7.2 7.6 8.7 8.5 9.8 6.2 PPA1 "IOPPP, PP, PP1, Ppase, SID6-8061" ENSG00000180817 "Pyrophosphatase (inorganic) 1" Q15181 10 70202830-70233911 "Enzymes, Predicted intracellular proteins" Hydrolase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA019878, HPA020096" Supported Supported Vesicles 110000 Vesicles "HPA019878: AB_1855601, HPA020096: AB_1855600" "unprognostic (1.50e-1)" "unprognostic (2.85e-1)" "unprognostic (4.71e-2)" "unprognostic (2.85e-1)" "unprognostic (1.42e-1)" "unprognostic (4.47e-2)" "unprognostic (2.86e-2)" "unprognostic (9.43e-2)" "unprognostic (3.34e-1)" "unprognostic (1.62e-1)" "unprognostic (2.13e-2)" "unprognostic (3.60e-2)" "unprognostic (1.82e-3)" "unprognostic (5.36e-2)" "unprognostic (2.37e-1)" "unprognostic (3.53e-2)" "unprognostic (2.74e-1)" 46.6 55.5 41.3 36.8 56.0 24.2 88.7 66.8 62.2 34.8 45.7 25.2 43.7 33.2 30.4 59.6 48.6 38.1 31.5 30.0 46.7 54.2 40.7 59.0 39.1 54.6 74.3 47.5 17.9 72.6 23.3 29.5 34.6 60.7 24.4 53.4 26.1 36.8 42.1 37.0 24.6 41.0 32.8 72.7 22.4 32.5 25.1 47.2 20.4 52.0 35.8 44.4 32.7 40.2 21.5 48.9 1.0 17.7 15.5 35.6 25.3 58.1 24.1 21.6 63.6 58.8 51.9 20.2 21.8 41.0 34.2 36.1 73.4 30.9 84.3 19.9 21.7 47.1 63.2 42.5 35.0 79.2 60.1 23.0 24.4 41.9 37.1 56.6 14.6 34.0 50.9 27.4 73.1 41.3 53.6 45.4 32.2 34.1 54.7 53.2 22.5 66.9 33.5 24.7 49.3 71.3 36.6 64.9 21.8 24.0 94.1 18.6 23.5 25.5 18.7 9.5 36.2 31.2 41.3 15.0 32.8 61.7 14.7 79.5 8.3 0.0 17.7 0.4 13.3 13.8 35.6 21.5 30.8 23.1 48.9 13.8 34.2 28.9 1.0 15.5 14.5 11.3 30.1 25.3 41.3 56.0 66.8 62.2 46.7 54.2 74.3 47.5 60.7 47.2 PPA2 FLJ20459 ENSG00000138777 "Pyrophosphatase (inorganic) 2" Q9H2U2 4 105369077-105474081 "Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins" Hydrolase "Cancer-related genes, Disease mutation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA030888, HPA031671, HPA031672" Supported Approved Nucleoplasm,Mitochondria 8300 Mitochondria Nucleoplasm "HPA030888: , HPA031671: AB_10603986, HPA031672: AB_2673988" "prognostic unfavourable (2.98e-4)" "unprognostic (5.64e-2)" "prognostic favourable (6.60e-4)" "unprognostic (9.26e-3)" "unprognostic (2.93e-2)" "unprognostic (5.10e-2)" "unprognostic (1.15e-1)" "unprognostic (2.44e-1)" "unprognostic (1.50e-1)" "unprognostic (1.20e-1)" "unprognostic (7.05e-2)" "unprognostic (9.54e-2)" "prognostic favourable (1.27e-11)" "unprognostic (3.69e-1)" "unprognostic (1.94e-1)" "unprognostic (2.00e-1)" "unprognostic (1.10e-1)" 9.2 18.0 18.4 17.2 15.4 24.0 20.6 12.3 17.6 10.2 19.8 9.3 20.3 18.1 13.3 20.7 14.8 10.7 18.7 42.5 15.6 15.3 23.7 21.2 23.1 34.8 17.2 12.1 9.5 25.0 10.4 15.0 9.3 15.4 16.1 16.7 12.6 21.4 26.8 29.6 15.0 16.8 22.8 12.4 12.1 15.0 9.7 10.7 9.4 14.3 28.2 10.6 12.2 9.5 20.0 35.3 14.7 20.8 22.0 17.0 14.6 11.5 5.5 10.7 18.1 6.8 5.5 7.8 6.5 8.6 8.0 5.7 12.1 17.0 9.5 8.7 5.3 5.8 21.4 10.3 9.5 13.4 7.6 8.5 8.9 11.0 5.4 20.1 8.2 5.3 10.7 5.5 4.3 7.7 14.1 13.1 7.3 14.6 17.1 14.5 7.8 18.7 15.2 6.6 9.3 26.5 8.9 11.0 6.6 4.5 26.7 9.4 14.0 16.4 4.1 5.8 11.3 6.2 11.3 11.6 14.6 9.9 10.1 10.9 7.8 14.7 15.0 9.7 15.3 20.8 13.3 20.0 16.0 16.2 35.3 16.6 15.5 17.0 6.4 22.0 16.2 17.7 15.9 14.6 18.4 15.4 12.3 17.6 15.6 15.3 17.2 12.1 15.4 10.7 PRDX6 "1-Cys, aiPLA2, AOP2, KIAA0106, MGC46173, NSGPx, p29, PRX" ENSG00000117592 "Peroxiredoxin 6" P30041 1 173477266-173488807 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Lipid degradation, Lipid metabolism" "Antioxidant, Hydrolase, Multifunctional enzyme, Oxidoreductase, Peroxidase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA006983, CAB008663" Supported Supported "Plasma membrane,Cytosol" 180000000 "Plasma membrane, Cytosol" "CAB008663: AB_1620994, HPA006983: AB_1079595" "unprognostic (9.92e-2)" "unprognostic (1.50e-1)" "unprognostic (3.67e-1)" "unprognostic (2.99e-3)" "unprognostic (1.96e-1)" "prognostic unfavourable (1.23e-5)" "unprognostic (5.71e-3)" "unprognostic (2.80e-2)" "unprognostic (5.27e-3)" "unprognostic (3.96e-3)" "unprognostic (3.19e-3)" "unprognostic (1.59e-1)" "prognostic unfavourable (9.51e-4)" "unprognostic (2.50e-1)" "unprognostic (7.12e-2)" "unprognostic (1.15e-1)" "unprognostic (4.73e-3)" 80.0 42.1 32.8 30.8 38.9 21.8 106.3 19.8 32.8 27.2 46.7 37.4 35.8 12.1 30.8 54.1 39.9 40.2 22.3 70.5 29.0 23.9 45.9 116.1 29.2 37.5 34.0 28.2 31.5 39.3 63.9 19.1 36.9 30.3 40.0 56.0 21.3 22.6 35.4 128.0 25.7 20.2 40.5 19.7 23.1 33.2 44.9 24.1 17.4 46.9 68.6 25.7 36.5 46.2 17.2 37.9 14.3 23.9 12.0 25.0 30.6 51.2 15.8 26.2 29.0 101.5 49.6 22.1 104.7 35.7 43.7 31.1 29.7 34.5 33.4 33.5 85.8 29.9 34.2 33.7 35.6 29.3 31.6 22.1 27.0 33.5 57.3 23.1 7.3 41.1 34.2 24.0 33.7 42.8 49.2 6.9 49.6 10.5 15.7 30.5 57.5 97.9 18.8 30.3 34.0 65.5 11.7 12.2 22.6 36.1 42.5 24.0 35.9 32.7 28.8 17.1 19.5 25.8 28.4 10.5 15.4 27.4 20.4 20.1 15.5 13.9 23.9 12.9 17.0 20.6 18.9 17.2 17.6 21.1 29.3 13.6 23.2 25.0 14.3 12.0 17.5 37.9 20.4 30.6 32.8 38.9 19.8 32.8 29.0 23.9 34.0 28.2 30.3 24.1 PRODH "HSPOX2, PIG6, PRODH1, PRODH2, TP53I6" ENSG00000100033 "Proline dehydrogenase 1" O43272 22 18912777-18936553 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" "Proline metabolism" Oxidoreductase "Disease mutation, Schizophrenia" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 48.9" "Cell line enriched" "Detected in some" 8 "RPTEC TERT1: 28.8" "Cancer enhanced" "Detected in many" "testis cancer: 11.0" "Low region specificity" "Detected in all" "Cell type enhanced" "Detected in single" "NK-cell: 1.0" "Low lineage specificity" "Detected in single" HPA020361 Approved "HPA020361: AB_10963116" "unprognostic (2.46e-2)" "prognostic favourable (1.54e-4)" "unprognostic (1.40e-1)" "unprognostic (3.70e-2)" "unprognostic (3.80e-2)" "unprognostic (1.20e-1)" "unprognostic (1.78e-2)" "unprognostic (1.07e-2)" "unprognostic (2.49e-2)" "unprognostic (6.56e-2)" "unprognostic (3.12e-2)" "unprognostic (1.61e-2)" "unprognostic (7.44e-2)" "unprognostic (1.07e-1)" "unprognostic (1.21e-1)" "unprognostic (5.34e-2)" "unprognostic (3.94e-2)" 3.8 2.3 20.8 2.8 19.3 2.0 3.3 9.8 21.3 2.0 3.5 16.2 0.1 13.8 2.3 2.2 8.8 2.4 2.2 4.6 22.2 10.8 9.9 6.6 8.6 2.3 14.9 21.8 2.4 2.2 1.9 1.5 2.4 13.5 2.6 2.6 7.4 2.1 2.4 15.5 13.0 48.9 1.9 12.6 2.2 2.1 3.5 9.8 0.1 4.3 4.1 3.7 2.1 2.3 0.4 0.4 0.0 0.0 1.0 0.3 0.0 0.0 0.6 0.0 0.2 0.7 0.0 0.1 0.0 0.0 0.0 0.0 0.8 0.1 0.0 0.3 0.0 2.1 2.9 0.2 0.0 0.0 0.1 0.0 0.0 0.0 0.6 0.0 0.0 0.0 2.3 0.0 0.4 0.0 0.0 0.0 0.0 0.1 0.0 0.4 3.4 0.0 0.0 0.0 0.3 28.8 0.6 0.1 0.2 0.6 0.9 0.2 1.0 0.0 0.0 0.0 0.1 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.4 0.4 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 20.8 19.3 9.8 21.3 22.2 10.8 14.9 21.8 13.5 9.8 PRUNE1 "DRES-17, H-PRUNE, HTCD37, PRUNE" ENSG00000143363 "Prune exopolyphosphatase 1" Q86TP1 1 151008420-151035713 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" Hydrolase "Disease mutation, Mental retardation, Neurodegeneration, Primary microcephaly" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell line enhanced" "Detected in all" "U-698: 61.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA028411 Uncertain Supported Cytosol 210000 Cytosol "HPA028411: AB_10603229" "unprognostic (6.24e-2)" "unprognostic (2.24e-1)" "unprognostic (4.17e-2)" "prognostic unfavourable (3.86e-4)" "unprognostic (6.91e-2)" "unprognostic (2.02e-1)" "unprognostic (2.12e-3)" "unprognostic (7.05e-2)" "unprognostic (4.08e-2)" "unprognostic (5.92e-2)" "unprognostic (1.73e-1)" "unprognostic (2.65e-1)" "prognostic unfavourable (3.48e-4)" "unprognostic (2.18e-1)" "unprognostic (3.21e-2)" "unprognostic (2.42e-2)" "unprognostic (1.36e-1)" 9.3 9.7 9.3 8.8 11.6 3.7 16.0 15.7 16.4 15.0 12.5 10.9 16.2 11.7 17.9 15.7 11.5 15.6 12.8 31.3 10.5 10.3 18.0 12.8 10.1 11.8 11.9 9.2 17.1 16.2 16.5 16.2 7.2 8.8 12.2 14.0 12.7 13.3 18.2 24.4 10.5 11.8 14.7 7.9 11.0 10.5 16.3 8.6 15.0 41.6 8.5 12.9 13.8 13.6 12.1 9.5 14.7 8.9 14.3 19.0 18.3 3.8 4.1 7.4 7.1 9.2 2.5 4.1 1.8 4.0 6.9 6.0 5.1 4.6 7.9 8.0 2.4 5.6 7.2 4.8 5.5 8.6 8.2 9.3 4.3 7.2 5.1 6.1 4.7 3.1 9.2 3.6 3.6 3.2 7.3 6.7 3.2 9.3 9.3 5.0 6.9 5.4 8.5 4.7 7.6 4.9 5.3 10.7 8.7 6.2 8.6 5.7 11.9 9.3 2.2 2.4 2.9 2.7 2.9 16.4 13.8 61.0 2.4 4.7 6.1 12.5 6.4 13.4 14.0 6.0 16.9 12.1 15.5 15.7 9.5 11.6 19.0 15.0 14.7 14.3 8.9 5.1 14.5 18.3 9.3 11.6 15.7 16.4 10.5 10.3 11.9 9.2 8.8 8.6 PXDN "D2S448, D2S448E, KIAA0230, MG50, PRG2, PXN" ENSG00000130508 Peroxidasin Q92626 2 1631887-1744852 "Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins" "Hydrogen peroxide" "Oxidoreductase, Peroxidase" "Disease mutation" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "breast: 60.8" "Cell line enhanced" "Detected in many" "EFO-21: 57.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Cell type enhanced" "Detected in some" "plasmacytoid DC: 2.0" "Low lineage specificity" "Detected in many" "Low region specificity" "Detected in many" "Low region specificity" "Detected in single" HPA012375 Approved "Secreted to extracellular matrix" 4000000 "HPA012375: AB_1855965" "unprognostic (4.37e-2)" "prognostic unfavourable (6.28e-4)" "unprognostic (2.08e-1)" "prognostic unfavourable (2.75e-4)" "unprognostic (8.16e-3)" "unprognostic (1.91e-1)" "unprognostic (1.92e-2)" "unprognostic (3.15e-3)" "unprognostic (6.50e-3)" "unprognostic (1.34e-2)" "unprognostic (6.78e-2)" "unprognostic (2.23e-1)" "unprognostic (6.13e-3)" "prognostic unfavourable (6.73e-4)" "unprognostic (1.18e-1)" "unprognostic (7.33e-3)" "unprognostic (5.54e-3)" 36.4 3.2 2.6 13.1 2.0 0.5 60.8 0.3 3.7 15.5 17.7 2.7 5.1 4.3 20.4 8.9 7.4 9.7 12.9 16.2 2.0 2.6 5.8 6.9 14.3 8.5 1.8 1.4 19.2 2.1 1.5 6.5 18.3 3.6 15.2 5.0 7.6 7.3 6.8 8.4 3.7 8.4 41.0 2.6 13.7 7.8 5.8 1.2 4.3 5.9 4.8 3.4 26.3 20.1 0.5 2.0 0.0 0.0 0.0 1.1 0.1 6.7 2.4 12.7 0.0 36.0 33.1 9.7 40.2 32.0 17.6 19.3 0.0 0.1 0.0 57.8 39.7 1.4 0.0 24.7 22.5 0.1 0.4 0.0 25.2 0.0 35.8 0.1 0.0 36.4 7.3 19.9 15.0 43.3 0.0 0.0 25.0 4.0 1.1 1.3 10.3 9.2 2.2 44.5 0.1 20.7 0.0 0.0 23.5 0.0 13.0 0.0 4.7 0.1 42.0 29.2 14.4 1.1 31.0 0.0 33.9 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.4 0.5 0.0 0.0 0.0 0.0 1.1 0.5 0.0 0.0 0.0 2.0 0.0 0.1 2.6 2.0 0.3 2.7 2.0 2.6 1.8 1.4 3.6 1.2 PXDNL "FLJ25471, PMR1" ENSG00000147485 "Peroxidasin like" A1KZ92 8 51319578-51809445 "Enzymes, Predicted intracellular proteins" "Hydrogen peroxide" "Endonuclease, Hydrolase, Nuclease, Oxidoreductase, Peroxidase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 7 "heart muscle: 59.1" "Group enriched" "Detected in some" 7 "AF22: 10.8;Daudi: 8.1;SH-SY5Y: 8.7" "Low cancer specificity" "Detected in some" "Not detected" "Not detected" "Cell type enriched" "Detected in single" 4 "memory B-cell: 1.5" "Lineage enriched" "Detected in single" 4 "B-cells: 1.5" HPA007919 Approved Nucleoplasm,Cytosol "Intracellular and membrane" "Nucleoplasm, Cytosol" "HPA007919: AB_1855966" "prognostic unfavourable (3.27e-5)" "unprognostic (4.59e-4)" "unprognostic (5.57e-3)" "unprognostic (2.83e-3)" "unprognostic (2.71e-1)" "unprognostic (5.14e-2)" "unprognostic (1.18e-1)" "unprognostic (7.18e-3)" "unprognostic (1.85e-1)" "unprognostic (1.15e-1)" "unprognostic (7.07e-2)" "unprognostic (1.07e-1)" "unprognostic (2.60e-4)" "unprognostic (2.28e-2)" "unprognostic (3.35e-2)" "unprognostic (2.42e-2)" "unprognostic (2.97e-4)" 1.1 0.1 0.3 0.1 0.2 0.0 0.2 0.1 0.9 0.1 0.1 0.0 0.2 0.0 0.3 7.9 0.4 0.1 0.7 59.1 0.2 0.3 1.0 0.1 0.2 0.3 0.3 0.3 0.1 0.1 0.0 0.1 0.0 0.3 0.1 0.0 1.8 1.1 0.3 0.9 0.2 0.2 0.1 0.2 0.3 0.1 5.2 0.0 0.1 0.2 2.5 0.3 0.2 0.1 1.5 0.3 0.3 0.0 0.0 0.1 0.0 0.6 0.0 10.8 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.1 8.1 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 1.3 0.0 0.0 0.0 0.0 0.0 0.1 8.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.6 0.5 0.0 0.0 0.2 0.0 0.0 0.3 0.0 0.0 0.1 0.0 0.0 1.5 0.0 0.0 0.0 0.1 0.1 0.1 0.3 0.0 0.0 0.3 0.1 0.0 0.3 0.2 0.1 0.9 0.2 0.3 0.3 0.3 0.3 0.0 RRM1 ENSG00000167325 "Ribonucleotide reductase catalytic subunit M1" P23921 11 4094707-4138876 "Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins" "DNA replication" "Allosteric enzyme, Oxidoreductase" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "lymphoid tissue: 78.6" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB022093, HPA057265, HPA064297" Enhanced Enhanced Cytosol 13000 Cytosol "CAB022093: , HPA057265: , HPA064297: " "unprognostic (4.47e-2)" "unprognostic (1.73e-2)" "unprognostic (1.99e-3)" "unprognostic (3.65e-1)" "unprognostic (2.83e-1)" "unprognostic (2.19e-1)" "prognostic unfavourable (1.53e-4)" "unprognostic (1.31e-2)" "unprognostic (3.43e-2)" "unprognostic (6.90e-2)" "unprognostic (1.06e-3)" "unprognostic (4.21e-2)" "unprognostic (6.88e-3)" "unprognostic (9.20e-3)" "unprognostic (6.16e-2)" "unprognostic (8.41e-2)" "unprognostic (9.93e-3)" 13.9 25.3 8.0 15.2 12.2 18.5 14.4 18.0 12.6 15.7 15.9 11.1 11.5 11.9 13.0 9.8 25.4 10.7 8.7 11.9 7.9 9.0 9.2 13.1 11.0 20.2 9.0 10.3 13.6 10.7 24.2 11.2 22.7 18.4 14.0 18.9 12.0 15.4 10.7 28.3 26.8 12.5 17.5 10.7 12.4 13.8 10.5 9.1 78.6 9.8 28.0 27.1 17.5 18.5 5.6 4.3 3.3 8.3 5.7 24.3 6.0 45.4 24.7 40.5 23.5 6.2 12.4 15.7 41.9 20.8 47.7 49.2 22.2 34.6 49.2 10.2 20.9 36.6 37.5 30.1 56.5 24.2 39.8 25.0 37.1 17.3 2.5 42.8 18.4 5.8 8.1 26.1 18.8 22.8 32.6 23.3 39.7 20.6 50.3 9.3 25.6 25.1 40.8 31.7 17.6 13.1 12.9 34.7 19.0 36.9 22.3 6.7 22.0 15.0 13.0 44.9 23.5 44.4 30.7 15.2 21.1 53.8 24.9 28.7 27.8 3.3 2.5 2.6 7.7 6.5 13.3 5.6 14.2 10.7 4.3 3.5 11.3 9.2 0.0 5.7 8.3 2.7 24.3 6.0 8.0 12.2 18.0 12.6 7.9 9.0 9.0 10.3 18.4 9.1 RRM2 ENSG00000171848 "Ribonucleotide reductase regulatory subunit M2" P31350 2 10120698-10131419 "Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "DNA replication" Oxidoreductase "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 4 "lymphoid tissue: 120.9" "Low cell line specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Not detected" "Not detected" "Cell type enhanced" "Detected in many" "T-reg: 10.4" "Lineage enriched" "Detected in many" 6 "T-cells: 10.4" HPA056994 Enhanced Supported Cytosol Cytosol "HPA056994: " "unprognostic (2.10e-2)" "unprognostic (1.62e-1)" "unprognostic (6.40e-3)" "unprognostic (4.42e-3)" "unprognostic (5.70e-2)" "unprognostic (1.69e-1)" "prognostic unfavourable (1.39e-5)" "unprognostic (1.04e-3)" "unprognostic (6.67e-3)" "unprognostic (4.53e-2)" "prognostic unfavourable (1.62e-4)" "unprognostic (5.11e-3)" "prognostic unfavourable (0.00e+0)" "unprognostic (3.05e-2)" "unprognostic (2.24e-1)" "unprognostic (1.38e-1)" "unprognostic (2.09e-2)" 4.7 2.2 0.4 32.6 0.4 29.0 4.2 0.4 0.9 3.5 9.3 0.4 0.4 5.2 2.1 1.7 21.6 0.7 5.0 3.3 0.4 0.5 2.0 3.9 5.7 16.4 0.6 0.1 0.9 2.9 0.0 0.7 5.4 0.3 1.0 10.6 0.1 2.9 0.0 0.5 2.8 11.3 3.2 0.8 19.8 5.4 8.0 0.0 120.9 0.8 22.3 33.1 3.8 5.2 1.4 0.3 0.6 0.2 1.8 10.4 2.6 29.1 17.7 25.0 17.1 2.2 4.1 24.8 47.7 23.6 34.1 37.1 29.5 14.0 26.8 6.6 14.9 14.3 40.5 24.6 41.8 60.0 15.6 51.6 17.0 26.0 0.1 38.2 24.8 1.4 0.5 41.7 3.5 27.5 21.6 79.5 42.4 22.0 42.2 20.5 20.2 20.7 31.8 54.6 18.4 16.7 22.2 24.8 20.4 39.2 27.9 4.8 15.0 6.9 9.6 26.1 38.0 19.5 66.8 51.6 40.5 54.7 18.5 32.4 37.5 0.3 0.1 0.1 3.7 0.0 0.0 1.4 2.6 2.9 0.2 0.4 0.2 1.2 0.6 1.8 0.2 0.3 10.4 2.6 0.4 0.4 0.4 0.9 0.4 0.5 0.6 0.1 0.3 0.0 RRM2B p53R2 ENSG00000048392 "Ribonucleotide reductase regulatory TP53 inducible subunit M2B" Q7LG56 8 102204502-102239118 "Disease related genes, Enzymes, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins" "DNA damage, DNA repair, DNA replication" Oxidoreductase "Disease mutation, FDA approved drug targets, Neuropathy, Primary mitochondrial disease, Progressive external ophthalmoplegia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB006854, HPA028812" Approved Supported Nucleoplasm,Cytosol Nucleoplasm Cytosol "CAB006854: , HPA028812: AB_10602246" "unprognostic (7.76e-3)" "unprognostic (4.14e-2)" "unprognostic (9.41e-3)" "unprognostic (3.41e-1)" "unprognostic (1.13e-2)" "unprognostic (1.28e-1)" "unprognostic (5.51e-2)" "unprognostic (1.35e-2)" "unprognostic (1.66e-1)" "unprognostic (9.40e-2)" "unprognostic (1.74e-2)" "unprognostic (1.03e-1)" "unprognostic (1.70e-2)" "unprognostic (4.32e-1)" "unprognostic (1.47e-1)" "unprognostic (2.52e-1)" "unprognostic (7.17e-2)" 11.8 18.6 11.7 11.5 11.4 4.3 9.3 8.5 13.5 9.5 10.1 9.8 9.5 10.2 8.2 10.8 8.0 9.7 8.2 11.3 17.5 12.8 17.5 15.1 15.8 12.6 14.9 10.6 9.7 9.5 34.7 24.8 11.6 23.1 11.2 11.1 7.7 9.7 10.9 34.6 7.4 7.6 8.2 26.1 10.6 7.1 6.6 9.4 6.3 37.1 8.1 13.1 10.7 7.0 7.4 6.2 18.3 8.4 3.0 3.3 2.8 5.6 10.1 12.0 7.1 17.0 16.4 9.6 13.2 16.0 7.1 8.3 3.6 4.6 36.4 12.5 14.6 2.1 5.8 13.4 10.1 5.9 6.3 9.1 4.3 7.6 13.8 2.8 19.5 20.8 25.3 7.8 11.9 19.8 6.7 5.6 22.7 5.6 4.8 5.3 6.7 7.5 3.1 4.9 7.3 16.5 6.5 3.0 6.0 6.9 3.7 7.9 9.9 6.3 15.1 11.0 21.4 7.6 3.6 5.9 5.4 33.1 16.2 4.3 11.6 10.0 5.1 5.3 2.2 4.5 3.3 5.6 2.0 2.8 6.2 7.4 2.3 2.5 18.3 3.0 8.4 1.8 1.4 2.8 11.7 11.4 8.5 13.5 17.5 12.8 14.9 10.6 23.1 9.4 SCD "FADS5, SCDOS" ENSG00000099194 "Stearoyl-CoA desaturase" O00767 10 100347124-100364834 "Enzymes, Predicted membrane proteins" "Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism" Oxidoreductase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 4 "adipose tissue: 245.0;brain: 130.0;breast: 94.0;heart muscle: 109.2;liver: 130.8" "Cell line enhanced" "Detected in many" "ASC diff: 199.5;CAPAN-2: 138.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low region specificity" "Detected in all" "HPA012107, HPA063921" Approved Enhanced "Endoplasmic reticulum" "Endoplasmic reticulum" "HPA012107: AB_1856610, HPA063921: " "unprognostic (2.10e-1)" "unprognostic (2.62e-3)" "unprognostic (7.86e-2)" "unprognostic (5.19e-2)" "unprognostic (1.24e-1)" "unprognostic (6.16e-2)" "unprognostic (1.13e-1)" "unprognostic (3.88e-2)" "unprognostic (6.53e-2)" "unprognostic (2.72e-1)" "unprognostic (1.47e-1)" "unprognostic (1.69e-1)" "prognostic unfavourable (7.56e-5)" "unprognostic (7.18e-2)" "unprognostic (3.27e-1)" "unprognostic (4.73e-2)" "prognostic unfavourable (7.79e-5)" 245.0 21.3 59.8 11.4 32.7 5.5 94.0 12.7 83.9 5.3 10.8 63.6 0.1 21.4 3.7 7.0 13.4 1.7 18.3 109.2 61.5 43.4 5.0 130.8 32.2 23.1 65.1 23.6 12.7 6.1 7.7 1.5 5.3 34.5 24.4 10.1 4.5 24.9 3.7 2.4 3.4 6.1 4.6 130.0 4.2 5.9 12.2 35.4 1.4 2.0 6.9 5.4 3.7 5.0 2.0 5.3 0.2 3.3 2.9 5.1 2.1 30.4 28.0 59.8 40.9 199.5 115.1 12.2 3.2 72.1 7.8 41.8 24.1 138.2 12.8 2.6 7.6 54.4 32.9 116.8 6.9 4.3 13.6 7.2 17.8 48.2 38.6 10.0 7.8 62.6 35.4 30.4 53.6 14.8 20.0 39.2 3.1 47.6 11.3 12.0 20.7 8.1 5.3 22.1 40.2 34.2 34.1 3.7 14.4 6.4 30.5 62.7 34.2 21.6 5.9 0.7 9.3 0.7 6.7 11.0 5.8 19.8 14.3 31.3 5.0 0.0 1.5 0.0 3.0 3.3 5.1 1.3 1.2 1.6 5.3 2.0 1.0 2.9 0.2 2.9 0.0 3.0 0.0 2.1 59.8 32.7 12.7 27.9 61.5 43.4 65.1 23.6 34.5 35.4 SCD5 "ACOD4, FADS4, FLJ21032, HSCD5, SCD4" ENSG00000145284 "Stearoyl-CoA desaturase 5" Q86SK9 4 82629539-82798857 "Enzymes, Predicted membrane proteins" "Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism" Oxidoreductase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 4 "adrenal gland: 69.1;brain: 137.3;epididymis: 44.5;ovary: 42.7" "Cell line enhanced" "Detected in many" "BJ: 27.1;RPTEC TERT1: 35.8" "Group enriched" "Detected in all" 6 "glioma: 152.4;thyroid cancer: 38.5" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low region specificity" "Detected in all" HPA042380 Uncertain "HPA042380: AB_10794797" "unprognostic (3.23e-2)" "unprognostic (3.84e-2)" "unprognostic (2.86e-1)" "unprognostic (6.98e-2)" "unprognostic (1.58e-1)" "unprognostic (2.95e-1)" "unprognostic (2.83e-1)" "unprognostic (3.82e-2)" "unprognostic (6.82e-2)" "unprognostic (3.22e-1)" "unprognostic (1.04e-1)" "unprognostic (2.37e-2)" "prognostic favourable (2.32e-5)" "unprognostic (1.28e-1)" "unprognostic (1.26e-1)" "unprognostic (3.88e-3)" "unprognostic (2.92e-2)" 3.0 69.1 61.2 2.7 48.6 2.5 3.0 33.5 137.3 5.9 3.0 50.4 1.8 3.0 6.7 44.5 3.7 9.3 5.1 3.5 49.6 43.4 15.4 2.3 7.5 2.3 58.2 36.3 42.7 18.1 2.2 6.9 4.4 42.0 6.9 3.0 6.3 5.6 12.4 1.7 4.8 3.7 6.2 57.1 3.0 4.3 14.8 43.4 1.2 16.4 0.0 3.0 3.8 2.0 0.9 1.3 3.0 1.2 2.0 7.2 1.8 4.4 2.8 14.5 7.4 8.0 5.2 0.3 27.1 13.4 11.9 9.2 0.3 0.7 8.8 9.5 5.6 7.9 4.2 3.0 15.0 1.7 1.9 0.4 3.5 0.4 1.2 3.9 2.9 4.1 12.2 2.4 2.1 19.0 0.6 1.1 6.2 1.7 16.0 0.9 1.1 1.9 13.7 8.6 6.9 35.8 4.4 8.1 4.6 4.5 0.4 2.6 0.6 2.0 23.3 12.8 7.5 4.8 7.3 2.5 1.0 0.9 6.2 4.1 3.6 3.0 1.2 0.4 7.2 0.5 4.6 0.5 1.7 4.3 0.5 0.9 1.5 5.1 2.0 2.0 0.9 1.3 0.4 1.8 61.2 48.6 33.5 41.2 49.6 43.4 58.2 36.3 42.0 43.4 SOAT1 "ACAT, SOAT, STAT" ENSG00000057252 "Sterol O-acyltransferase 1" P35610 1 179293714-179358680 "Enzymes, FDA approved drug targets, Predicted membrane proteins" "Cholesterol metabolism, Lipid metabolism, Steroid metabolism, Sterol metabolism" "Acyltransferase, Transferase" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "adrenal gland: 87.4" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB009533, HPA047171" Enhanced Enhanced "Endoplasmic reticulum" "Endoplasmic reticulum" "CAB009533: AB_633499, HPA047171: " "unprognostic (3.29e-2)" "unprognostic (7.60e-2)" "unprognostic (1.11e-1)" "unprognostic (3.21e-2)" "unprognostic (2.83e-1)" "unprognostic (1.81e-3)" "unprognostic (7.81e-3)" "unprognostic (3.29e-1)" "unprognostic (9.00e-2)" "unprognostic (9.84e-2)" "unprognostic (1.06e-1)" "unprognostic (5.45e-3)" "unprognostic (7.02e-3)" "unprognostic (4.67e-3)" "unprognostic (9.64e-2)" "unprognostic (4.67e-2)" "unprognostic (1.82e-1)" 23.9 87.4 4.1 8.3 5.7 7.0 9.6 2.9 4.0 6.8 7.2 5.6 7.8 5.5 8.2 6.0 3.4 8.3 9.8 5.7 5.5 4.1 12.1 8.8 18.6 13.0 6.2 2.3 10.8 15.5 8.1 14.6 11.6 4.9 13.1 6.9 9.6 51.1 8.9 4.1 5.8 7.0 7.5 10.5 13.6 8.1 6.8 4.9 4.0 6.2 2.9 7.2 9.4 8.7 6.6 24.3 19.8 26.8 18.5 16.0 14.8 20.2 9.5 7.8 11.6 30.5 16.7 42.0 9.8 17.3 21.7 25.5 9.7 23.2 11.5 15.5 17.8 7.5 24.9 5.8 23.5 13.1 5.1 5.3 8.0 10.1 12.5 9.1 2.1 13.2 3.8 25.4 21.8 9.3 11.4 5.9 33.8 4.3 9.6 2.9 3.8 3.1 12.1 10.1 6.7 19.2 12.7 2.4 6.1 15.1 6.4 5.6 6.7 6.3 8.8 25.9 12.4 28.3 21.5 8.4 30.6 9.8 10.3 4.9 48.0 19.6 26.8 0.7 14.0 17.0 13.5 6.6 13.1 13.1 24.3 5.5 12.7 12.6 19.8 18.5 11.1 4.4 16.0 14.8 4.1 5.7 2.9 4.0 5.5 4.1 6.2 2.3 4.9 4.9 SOAT2 ACAT2 ENSG00000167780 "Sterol O-acyltransferase 2" O75908 12 53103518-53124538 "Enzymes, Predicted membrane proteins" "Cholesterol metabolism, Lipid metabolism, Steroid metabolism, Sterol metabolism" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 14 "intestine: 60.8" "Group enriched" "Detected in some" 5 "CACO-2: 9.6;Hep G2: 20.9;U-266/70: 7.0" "Group enriched" "Detected in some" 8 "liver cancer: 5.2;testis cancer: 5.5" "Not detected" "Not detected" "Group enriched" "Detected in some" 4 "MAIT T-cell: 3.7;memory CD4 T-cell: 1.5;memory CD8 T-cell: 2.7;naive CD8 T-cell: 1.5" "Lineage enriched" "Detected in single" 7 "T-cells: 3.7" "Not detected" "Not detected" "Low region specificity" "Detected in all" "unprognostic (2.53e-1)" "unprognostic (2.72e-3)" "unprognostic (1.15e-1)" "unprognostic (1.40e-1)" "unprognostic (1.30e-4)" "unprognostic (3.88e-3)" "unprognostic (9.26e-2)" "unprognostic (4.20e-2)" "unprognostic (1.32e-1)" "unprognostic (3.29e-1)" "unprognostic (1.06e-2)" "unprognostic (2.53e-1)" "unprognostic (1.83e-2)" "unprognostic (9.05e-2)" "unprognostic (2.37e-1)" "unprognostic (7.58e-3)" "unprognostic (3.28e-1)" 0.5 0.0 0.2 0.2 0.2 0.2 0.6 0.2 0.2 0.9 16.4 0.2 0.2 12.3 0.7 0.3 0.2 0.9 0.4 0.2 0.2 0.0 0.6 4.2 0.2 0.6 0.2 0.2 0.4 0.2 0.0 0.3 0.2 0.2 0.6 0.0 0.2 0.4 0.2 0.2 0.4 60.8 0.2 0.3 2.2 0.3 0.2 0.2 0.2 0.4 0.2 0.3 0.3 1.1 0.0 0.0 0.0 0.3 0.5 3.7 0.2 0.2 0.1 0.0 0.0 0.0 0.2 0.0 0.3 0.0 0.3 0.4 9.6 0.1 0.0 0.0 0.4 0.7 0.0 0.0 0.6 0.0 0.0 0.9 0.0 20.9 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.3 2.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.0 7.0 1.5 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.3 3.7 0.0 1.5 2.7 0.0 0.0 0.4 1.5 0.0 0.5 0.0 0.0 0.0 0.2 0.2 0.2 0.2 0.2 0.2 0.0 0.2 0.2 0.2 0.2 SULT1A1 "P-PST, STP, STP1" ENSG00000196502 "Sulfotransferase family 1A member 1" P50225 16 28605196-28623625 "Enzymes, Predicted intracellular proteins" "Catecholamine metabolism, Lipid metabolism, Steroid metabolism" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 98.1" "Group enriched" "Detected in many" 4 "EFO-21: 41.4;Hep G2: 82.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 7 "classical monocyte: 50.6;intermediate monocyte: 39.2;myeloid DC: 22.9;neutrophil: 47.7;non-classical monocyte: 22.3" "Group enriched" "Detected in many" 26 "dendritic cells: 22.9;granulocytes: 47.7;monocytes: 50.6" "HPA049500, HPA051051" Supported 3700000 "HPA049500: , HPA051051: " "unprognostic (2.57e-2)" "unprognostic (2.80e-2)" "unprognostic (8.40e-2)" "unprognostic (1.30e-1)" "unprognostic (5.60e-3)" "unprognostic (7.63e-2)" "unprognostic (4.17e-2)" "prognostic favourable (7.02e-4)" "unprognostic (1.30e-1)" "unprognostic (2.40e-1)" "unprognostic (6.71e-2)" "unprognostic (2.07e-1)" "unprognostic (3.70e-3)" "unprognostic (1.49e-1)" "unprognostic (4.10e-2)" "unprognostic (7.39e-2)" "unprognostic (1.89e-2)" 10.2 36.1 12.0 7.2 15.4 9.3 5.7 15.8 19.8 4.6 21.4 4.5 15.5 54.2 3.7 14.4 3.1 6.6 5.4 9.7 14.7 10.4 11.0 98.1 26.7 8.4 9.2 14.9 3.5 9.6 6.7 10.0 5.6 10.3 3.7 17.5 12.2 11.5 22.5 4.9 1.4 41.1 5.2 6.3 23.2 7.2 5.1 4.6 4.0 13.4 2.6 3.7 6.3 2.2 0.3 22.9 47.7 50.6 0.9 1.5 19.3 1.5 0.6 0.8 2.7 0.0 0.0 5.5 0.0 0.0 0.0 0.0 0.3 10.3 0.2 41.4 0.0 0.6 0.8 2.8 0.0 0.3 7.3 2.8 3.1 82.0 4.9 0.0 3.2 0.2 0.2 0.0 0.0 0.7 1.1 1.3 0.8 9.7 0.2 2.2 0.7 0.0 3.0 0.3 5.4 0.7 0.8 2.5 0.2 0.7 13.4 0.3 8.0 7.9 5.4 0.2 2.0 0.2 0.1 3.2 1.9 0.4 0.7 15.1 0.0 4.9 50.6 0.9 0.6 39.2 0.7 0.3 0.6 0.5 22.9 0.1 0.9 0.6 47.7 0.9 22.3 1.7 1.5 19.3 12.0 15.4 15.8 19.8 14.7 10.4 9.2 14.9 10.3 4.6 TPO TPX ENSG00000115705 "Thyroid peroxidase" P07202 2 1374223-1543711 "Disease related genes, Enzymes, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Hydrogen peroxide, Thyroid hormones biosynthesis" "Oxidoreductase, Peroxidase" "Congenital hypothyroidism, Disease mutation, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 58 "thyroid gland: 411.3" "Group enriched" "Detected in some" 5 "Karpas-707: 14.0;RPMI-8226: 5.9" "Cancer enriched" "Detected in some" 364 "thyroid cancer: 188.3" "Not detected" "Not detected" "Group enriched" "Detected in some" 13 "memory CD4 T-cell: 5.1;T-reg: 3.0" "Lineage enriched" "Detected in single" 21 "T-cells: 5.1" "Low region specificity" "Detected in single" "Not detected" "Not detected" "HPA007987, CAB009587" Enhanced "Intracellular and membrane" "CAB009587: , HPA007987: AB_1080270" "unprognostic (1.55e-1)" "unprognostic (1.04e-1)" "unprognostic (2.88e-1)" "unprognostic (1.77e-2)" "unprognostic (3.56e-2)" "unprognostic (9.11e-2)" "unprognostic (2.24e-2)" "unprognostic (1.85e-1)" "unprognostic (1.32e-1)" "unprognostic (1.19e-4)" "unprognostic (2.61e-2)" "unprognostic (3.29e-1)" "unprognostic (5.44e-4)" "unprognostic (1.21e-1)" "unprognostic (3.73e-2)" "unprognostic (4.98e-3)" "unprognostic (7.10e-3)" 1.1 0.0 0.1 0.1 0.1 0.0 0.9 0.1 0.1 0.1 0.3 0.1 0.1 0.0 0.1 0.1 0.1 0.0 0.4 1.0 0.1 0.0 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 1.2 0.1 0.5 0.0 0.2 0.1 0.1 7.1 0.2 0.1 0.1 0.1 411.3 0.1 0.1 0.1 0.1 0.1 0.0 0.2 0.0 0.0 5.1 0.9 0.1 0.1 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.1 0.0 0.0 0.4 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 14.0 0.0 1.4 0.0 0.0 0.1 0.2 0.0 0.0 5.9 0.0 0.0 0.0 0.1 0.0 2.0 0.0 1.1 0.0 0.1 0.1 0.0 0.1 0.0 0.1 0.3 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 5.1 0.3 0.0 0.1 0.0 0.3 0.2 0.0 0.0 0.0 3.0 0.9 0.1 0.1 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.1 TPP1 "CLN2, SCAR7" ENSG00000166340 "Tripeptidyl peptidase 1" O14773 11 6612763-6619485 "Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Hydrolase, Protease, Serine protease" "Disease mutation, Epilepsy, Neurodegeneration, Neuronal ceroid lipofuscinosis, Spinocerebellar ataxia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA037709, HPA044868" Enhanced "Intracellular and membrane" 13000000 "HPA037709: AB_10672913, HPA044868: AB_2679122" "unprognostic (8.27e-3)" "unprognostic (5.85e-2)" "unprognostic (7.12e-3)" "unprognostic (3.34e-3)" "unprognostic (1.56e-2)" "prognostic unfavourable (4.31e-4)" "prognostic unfavourable (1.11e-4)" "unprognostic (6.32e-2)" "unprognostic (3.01e-1)" "unprognostic (2.39e-2)" "unprognostic (1.31e-1)" "unprognostic (6.54e-2)" "unprognostic (6.23e-2)" "prognostic unfavourable (4.46e-4)" "unprognostic (3.87e-2)" "unprognostic (2.59e-1)" "unprognostic (1.12e-2)" 37.4 64.6 32.2 28.8 36.2 43.0 23.1 15.1 33.3 24.0 26.8 41.7 13.2 28.0 32.0 22.3 20.3 18.0 26.9 25.6 24.5 25.1 36.0 45.1 35.9 42.3 31.0 29.3 22.0 14.8 35.1 30.0 56.4 25.4 19.4 28.2 43.4 18.4 29.1 15.4 15.5 31.4 42.4 32.8 69.0 19.8 17.9 24.7 21.7 24.0 9.1 26.9 25.6 29.4 9.4 43.5 12.8 38.9 7.0 15.3 26.2 4.9 10.1 5.1 9.6 59.4 32.9 3.9 9.8 46.5 7.6 13.3 4.2 21.3 7.2 6.5 24.7 14.9 10.0 13.7 11.6 7.1 5.7 5.8 5.2 11.2 44.9 8.3 35.3 49.3 22.4 8.9 19.8 32.5 11.0 21.6 22.2 6.1 2.6 10.3 3.6 12.2 6.5 4.3 14.0 13.5 7.8 0.6 3.9 10.5 7.8 18.3 5.2 15.9 37.1 22.0 6.3 19.8 3.5 18.3 17.9 2.5 28.0 19.6 11.5 12.8 37.7 8.9 10.7 38.9 8.7 9.4 8.5 11.0 43.5 8.5 5.8 7.6 6.9 7.0 26.4 24.2 15.3 26.2 32.2 36.2 15.1 33.3 24.5 25.1 31.0 29.3 25.4 24.7 TXN TRX ENSG00000136810 Thioredoxin P10599 9 110243811-110256640 "Plasma proteins, Predicted intracellular proteins" "Electron transport, Transcription, Transcription regulation, Transport" Activator "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "tongue: 447.3" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Group enriched" "Detected in all" 4 "dendritic cells: 127.1;granulocytes: 104.5" "Low region specificity" "Detected in all" "CAB008678, HPA047478, HPA055752" Enhanced Enhanced Nucleoplasm,Cytosol "Intracellular and membrane" 25000000 "Nucleoplasm, Cytosol" "CAB008678: AB_1623676, HPA047478: AB_2680063, HPA055752: AB_2682907" "unprognostic (2.12e-2)" "unprognostic (1.27e-1)" "unprognostic (9.77e-2)" "prognostic favourable (3.40e-6)" "unprognostic (1.80e-2)" "unprognostic (2.13e-2)" "unprognostic (5.52e-3)" "unprognostic (1.37e-2)" "unprognostic (1.75e-1)" "unprognostic (3.36e-2)" "unprognostic (5.93e-3)" "unprognostic (1.66e-1)" "unprognostic (4.96e-3)" "unprognostic (7.80e-2)" "unprognostic (8.55e-2)" "unprognostic (2.99e-2)" "unprognostic (8.51e-2)" 23.6 16.7 26.6 18.2 16.9 35.8 25.9 10.8 19.7 30.8 57.9 7.7 17.5 40.7 15.5 20.4 162.3 27.5 22.2 11.7 20.9 19.0 65.8 69.4 39.0 19.4 21.3 14.1 18.2 22.0 5.3 8.0 41.2 28.7 15.5 50.6 8.0 50.2 16.3 16.0 26.3 58.9 21.9 17.6 19.8 26.3 9.2 7.0 40.0 18.9 447.3 82.0 31.3 27.1 12.8 127.1 104.5 25.1 14.2 26.0 18.8 61.9 85.2 23.1 25.5 58.3 76.0 34.0 75.5 70.5 52.6 40.1 55.3 74.8 55.3 32.5 69.7 140.2 32.9 100.6 51.7 81.9 73.0 27.7 79.9 95.6 66.7 68.7 84.6 53.9 66.4 77.0 58.3 46.2 46.5 53.3 71.9 50.2 57.2 103.1 49.1 104.0 24.0 78.3 64.4 67.3 44.0 50.3 18.0 81.4 66.2 51.2 63.5 47.6 55.4 54.3 35.1 101.8 93.5 27.0 76.2 47.0 78.8 60.0 75.3 32.2 25.1 104.5 14.5 15.1 13.9 12.8 20.5 17.4 37.1 5.6 7.7 11.5 99.7 14.2 9.6 127.1 26.0 18.8 26.6 16.9 10.8 19.7 20.9 19.0 21.3 14.1 28.7 7.0 TXN2 MT-TRX ENSG00000100348 "Thioredoxin 2" Q99757 22 36467036-36482030 "Disease related genes, Predicted intracellular proteins" "Electron transport, Transport" "Neurodegeneration, Primary mitochondrial disease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA000994, CAB008681" Approved Enhanced Mitochondria Mitochondria "CAB008681: AB_1623682, HPA000994: AB_1080267" "unprognostic (5.11e-2)" "unprognostic (4.40e-3)" "unprognostic (4.40e-3)" "unprognostic (1.07e-2)" "unprognostic (5.85e-2)" "unprognostic (4.28e-2)" "unprognostic (4.02e-2)" "unprognostic (5.05e-2)" "unprognostic (2.15e-1)" "unprognostic (1.78e-1)" "unprognostic (3.17e-2)" "prognostic favourable (2.04e-4)" "prognostic favourable (1.17e-6)" "unprognostic (1.49e-2)" "unprognostic (2.78e-1)" "unprognostic (1.06e-1)" "unprognostic (2.05e-1)" 22.1 69.9 33.4 24.7 33.2 23.5 41.9 23.2 51.1 23.0 25.9 20.8 24.5 36.9 19.8 22.7 28.7 26.9 27.6 60.1 28.0 28.6 33.4 51.7 27.9 35.5 30.3 31.7 35.0 51.1 30.8 17.3 19.6 30.4 21.6 26.2 24.6 25.0 27.5 72.3 21.0 28.1 26.3 35.6 25.2 26.7 19.1 21.2 16.2 29.2 37.3 23.0 23.0 19.8 31.7 51.3 14.4 43.3 32.0 30.0 45.1 14.5 19.9 21.8 37.3 32.8 35.7 25.1 20.0 31.4 33.8 38.4 24.1 15.4 36.8 18.6 31.2 22.2 41.7 34.3 19.7 25.2 36.3 42.0 27.2 35.5 27.7 50.4 40.1 47.7 27.3 28.2 22.1 30.6 43.9 30.5 30.2 21.5 22.9 39.1 17.7 26.3 21.0 23.0 25.5 34.2 23.7 30.4 30.7 20.2 44.3 36.1 31.2 49.0 24.0 37.7 29.4 20.7 19.6 24.8 17.6 35.8 34.0 31.5 21.4 5.2 40.8 7.1 25.7 43.3 26.8 31.7 25.6 27.0 51.3 29.0 30.0 27.9 14.4 32.0 35.2 39.1 24.8 45.1 33.4 33.2 23.2 51.1 28.0 28.6 30.3 31.7 30.4 21.2 TXNRD1 "GRIM-12, Trxr1, TXNR" ENSG00000198431 "Thioredoxin reductase 1" Q16881 12 104215779-104350305 "Cancer-related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins" "Electron transport, Transport" Oxidoreductase "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell line enhanced" "Detected in all" "fHDF/TERT166: 143.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA001395, CAB004607, CAB015834, HPA043871" Approved Supported Nucleoplasm 5900000 Nucleoplasm "CAB004607: AB_628405, CAB015834: , HPA001395: AB_1858377, HPA043871: " "unprognostic (2.52e-2)" "unprognostic (1.16e-1)" "unprognostic (5.48e-2)" "unprognostic (1.01e-1)" "unprognostic (3.15e-1)" "unprognostic (1.94e-2)" "prognostic unfavourable (1.12e-5)" "unprognostic (5.55e-2)" "unprognostic (1.18e-1)" "unprognostic (1.08e-1)" "unprognostic (6.42e-2)" "unprognostic (2.21e-1)" "prognostic unfavourable (1.20e-5)" "unprognostic (2.13e-1)" "unprognostic (1.27e-1)" "unprognostic (1.18e-2)" "unprognostic (8.80e-2)" 19.1 79.2 14.1 15.6 16.9 22.6 18.5 11.1 13.7 13.0 21.8 9.7 19.7 23.5 23.5 14.7 16.7 19.0 23.2 32.4 11.0 11.7 25.3 19.6 29.3 18.1 12.0 10.9 16.4 7.9 10.5 16.2 30.8 16.4 25.3 19.1 18.1 10.6 26.5 30.0 5.7 17.0 99.6 10.9 14.9 24.2 14.8 8.9 15.6 16.5 16.9 13.2 73.2 72.0 8.1 14.2 37.6 16.2 8.3 10.2 8.7 22.0 102.6 11.9 11.2 57.5 32.2 41.6 41.0 26.0 18.5 19.2 10.8 32.9 16.5 19.1 143.4 7.7 23.5 15.7 22.0 8.0 10.2 13.9 80.6 45.6 92.3 21.7 15.2 18.3 16.2 40.9 13.1 63.4 19.1 7.8 27.7 10.6 22.2 9.9 11.5 105.8 22.0 8.3 14.3 21.5 12.1 18.6 11.2 33.1 52.4 32.7 12.4 12.8 84.7 9.1 18.9 20.3 33.5 8.6 16.8 24.8 19.1 12.0 53.9 33.0 10.6 24.7 9.1 14.0 10.2 8.1 8.4 9.0 14.2 5.2 7.6 6.6 37.6 8.3 16.2 9.2 7.1 8.7 14.1 16.9 11.1 11.2 11.0 11.7 12.0 10.9 16.4 8.9 TXNRD2 "TR, TR3, TRXR2" ENSG00000184470 "Thioredoxin reductase 2" Q9NNW7 22 19875517-19941992 "Enzymes, Plasma proteins, Predicted intracellular proteins" Oxidoreductase "Disease mutation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell line enhanced" "Detected in all" "U-2 OS: 48.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB002007, HPA003323" Supported Supported Mitochondria,Cytosol 410000 Mitochondria Cytosol "CAB002007: , HPA003323: AB_1080396" "unprognostic (3.17e-2)" "unprognostic (8.72e-2)" "unprognostic (4.30e-1)" "unprognostic (9.71e-3)" "unprognostic (7.25e-2)" "unprognostic (6.35e-2)" "unprognostic (3.21e-1)" "unprognostic (1.12e-1)" "unprognostic (2.78e-1)" "unprognostic (2.83e-1)" "unprognostic (4.94e-3)" "unprognostic (2.49e-1)" "prognostic favourable (1.10e-7)" "unprognostic (2.47e-1)" "unprognostic (5.99e-2)" "unprognostic (1.69e-1)" "unprognostic (1.10e-1)" 9.8 30.2 8.5 8.3 10.1 11.6 7.4 19.0 15.0 8.3 10.3 9.0 7.6 9.2 11.9 12.3 8.8 8.4 13.0 22.6 8.3 7.5 13.9 40.9 10.8 8.4 7.8 9.7 11.9 13.0 9.9 9.9 14.0 7.1 17.9 4.5 10.0 15.2 8.8 16.5 6.0 10.2 5.4 5.6 11.2 14.6 10.5 6.8 4.9 12.6 9.2 10.5 7.5 7.9 4.8 9.1 5.8 12.1 4.8 4.9 4.9 6.3 13.2 1.2 5.1 2.4 3.4 3.0 6.1 7.2 11.1 8.2 12.2 6.6 3.5 14.9 6.4 11.3 6.1 8.4 4.2 6.7 15.1 5.9 10.5 7.2 4.6 6.6 2.9 3.3 6.4 5.7 4.8 31.4 32.8 6.0 8.6 15.4 2.2 9.9 6.1 9.4 3.4 29.3 3.2 6.7 6.9 6.5 5.7 10.5 13.8 7.0 11.2 9.0 17.4 8.1 48.8 6.7 12.8 6.0 4.4 2.2 7.8 5.1 10.2 3.2 12.1 5.8 4.3 9.2 3.3 4.8 3.8 3.9 9.1 3.6 4.9 4.0 1.3 4.8 8.7 3.4 2.4 4.9 8.5 10.1 19.0 15.0 8.3 7.5 7.8 9.7 7.1 6.8 UGT1A1 "GNT1, UGT1, UGT1A" ENSG00000241635 "UDP glucuronosyltransferase family 1 member A1" P22309 2 233760248-233773299 "Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Cancer-related genes, Disease mutation" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 16 "intestine: 48.6;liver: 120.3" "Cell line enhanced" "Detected in some" "CACO-2: 4.2;HaCaT: 11.0;PC-3: 5.0;RT4: 26.1" "Cancer enriched" "Detected in some" 19 "liver cancer: 16.4" "Not detected" "Not detected" "Cell type enhanced" "Detected in some" "neutrophil: 4.7" "Low lineage specificity" "Detected in many" "Not detected" "Not detected" "unprognostic (7.28e-2)" "unprognostic (2.49e-2)" "unprognostic (3.60e-1)" "unprognostic (5.69e-2)" "unprognostic (4.17e-3)" "unprognostic (6.31e-3)" "unprognostic (1.94e-5)" "unprognostic (2.78e-3)" "unprognostic (2.99e-4)" 0.1 0.0 0.1 0.1 0.1 0.0 0.1 0.1 0.2 0.2 35.6 0.1 0.1 48.6 0.1 0.1 4.3 0.0 0.3 0.1 0.1 0.0 4.5 120.3 0.1 0.1 0.1 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.3 0.4 0.1 0.7 0.1 0.1 0.9 48.2 0.5 0.1 0.1 1.3 0.2 0.1 0.1 0.2 0.1 0.1 5.2 0.8 1.0 0.4 4.7 0.4 1.1 0.5 0.2 0.2 0.8 0.1 0.2 0.1 0.1 0.5 0.0 0.0 0.0 0.0 4.2 0.3 0.1 2.0 0.0 11.0 0.0 0.2 0.0 0.2 0.1 0.1 0.4 1.1 0.0 0.4 0.1 0.2 0.5 0.0 0.0 0.0 0.1 0.4 0.0 0.5 0.1 0.2 0.4 5.0 0.1 0.1 0.4 0.0 26.1 0.2 0.3 2.0 0.3 0.0 0.1 0.0 0.0 0.1 0.1 0.2 0.0 0.1 0.1 0.1 0.6 0.3 0.2 2.1 0.4 0.4 0.4 0.3 0.3 0.4 0.4 0.3 0.1 1.0 0.4 0.5 4.7 1.1 0.4 0.4 0.3 0.2 0.1 0.1 0.1 0.2 0.1 0.0 0.1 0.1 0.1 0.1 UGT1A10 UGT1J ENSG00000242515 "UDP glucuronosyltransferase family 1 member A10" Q9HAW8 2 233636454-233773305 "Cancer-related genes, Enzymes, Predicted intracellular proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 6 "esophagus: 9.4;gallbladder: 8.4;intestine: 31.1;stomach 1: 12.4" "Cell line enriched" "Detected in single" 142 "RT4: 106.4" "Cancer enhanced" "Detected in many" "urothelial cancer: 9.7" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Intracellular and membrane" "unprognostic (9.33e-2)" "unprognostic (7.64e-2)" "unprognostic (2.45e-3)" "unprognostic (1.73e-1)" "prognostic unfavourable (4.55e-4)" "unprognostic (1.49e-10)" "unprognostic (2.90e-1)" "unprognostic (1.50e-1)" "unprognostic (3.59e-3)" 0.3 0.0 0.3 2.6 0.3 0.0 0.3 0.3 0.3 0.3 19.2 0.3 0.3 31.1 0.3 0.3 9.4 0.1 8.4 0.3 0.3 0.0 0.3 1.4 0.6 0.3 0.3 0.3 0.3 0.3 0.0 0.3 0.3 0.3 0.3 14.3 0.3 0.9 0.3 0.3 0.3 20.2 0.5 0.3 0.3 12.4 1.0 0.3 0.3 0.3 0.3 1.4 0.9 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 106.4 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.3 0.3 0.3 0.3 0.0 0.3 0.3 0.3 0.3 UGT1A3 UGT1C ENSG00000243135 "UDP glucuronosyltransferase family 1 member A3" P35503 2 233729108-233773299 "Cancer-related genes, Enzymes, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 15 "liver: 40.6" "Cell line enriched" "Detected in some" 9 "HaCaT: 16.4" "Cancer enriched" "Detected in single" 6 "liver cancer: 2.1" "Not detected" "Not detected" "Not detected" "Not detected" "unprognostic (5.15e-2)" "unprognostic (9.93e-2)" "unprognostic (2.97e-1)" "unprognostic (4.59e-2)" "unprognostic (1.04e-4)" "unprognostic (8.22e-2)" "unprognostic (2.08e-3)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 40.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 16.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.7 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 1.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 UGT1A4 "HUG-BR2, UGT1D" ENSG00000244474 "UDP glucuronosyltransferase family 1 member A4" P22310 2 233718778-233773299 "Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 51 "liver: 99.4" "Cell line enhanced" "Detected in some" "HaCaT: 1.6;HL-60: 1.3;RH-30: 2.2" "Cancer enriched" "Detected in single" 487 "liver cancer: 24.3" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "unprognostic (9.89e-3)" "unprognostic (6.77e-5)" "unprognostic (2.59e-1)" "unprognostic (3.50e-3)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.9 0.0 0.0 1.5 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 99.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.6 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 1.3 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.6 0.2 0.0 0.0 2.2 0.0 0.0 0.7 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 UGT1A5 UGT1E ENSG00000240224 "UDP glucuronosyltransferase family 1 member A5" P35504 2 233712992-233773299 "Enzymes, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Tissue enhanced" "Detected in some" "gallbladder: 3.7;intestine: 13.9" "Cell line enhanced" "Detected in some" "RPMI-8226: 1.7;RT4: 1.6" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "unprognostic (2.18e-3)" "unprognostic (1.36e-1)" 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 13.9 0.0 0.0 11.2 0.0 0.0 0.2 0.0 3.7 0.0 0.0 0.0 0.2 2.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.3 9.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.7 0.0 1.6 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 UGT1A6 "GNT1, HLUGP, UGT1F" ENSG00000167165 "UDP glucuronosyltransferase family 1 member A6" P19224 2 233691607-233773300 "Enzymes, Predicted intracellular proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 5 "kidney: 111.7;liver: 50.1;urinary bladder: 32.7" "Cell line enhanced" "Detected in some" "CACO-2: 13.4;EFO-21: 20.8;HaCaT: 74.4;RT4: 37.6" "Cancer enhanced" "Detected in many" "renal cancer: 7.6" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "CAB009819, HPA054065" Enhanced "CAB009819: AB_2241481, HPA054065: " "unprognostic (9.09e-2)" "unprognostic (6.07e-2)" "unprognostic (5.43e-2)" "unprognostic (6.03e-2)" "prognostic unfavourable (2.89e-6)" "unprognostic (2.79e-1)" "unprognostic (6.18e-2)" "unprognostic (2.09e-3)" "unprognostic (9.97e-2)" "unprognostic (2.16e-2)" "unprognostic (3.52e-1)" "unprognostic (7.50e-2)" "unprognostic (2.01e-2)" 0.1 0.0 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.8 0.5 0.2 0.5 2.0 0.3 0.9 13.0 0.0 1.1 0.1 0.1 0.0 111.7 50.1 1.9 0.1 0.1 0.1 0.1 0.1 0.0 0.5 0.3 0.1 3.3 0.4 0.1 1.3 1.2 0.1 3.8 1.2 2.3 0.1 0.1 8.1 0.2 0.1 0.5 0.2 5.6 8.7 32.7 2.9 0.0 0.0 0.0 0.0 0.8 0.0 0.0 1.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 13.4 0.4 0.0 20.8 0.0 74.4 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 8.0 0.0 0.0 0.0 0.0 0.0 0.0 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 37.6 0.0 0.0 1.8 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.1 0.1 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.1 UGT1A7 UGT1G ENSG00000244122 "UDP glucuronosyltransferase family 1 member A7" Q9HAW7 2 233681938-233773299 "Enzymes, Predicted intracellular proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 12 "esophagus: 54.4;lymphoid tissue: 40.2;tongue: 23.6" "Cell line enriched" "Detected in some" 14 "SiHa: 49.4" "Group enriched" "Detected in some" 10 "cervical cancer: 1.2;head and neck cancer: 2.3;lung cancer: 3.0" "Not detected" "Not detected" "Cell type enhanced" "Detected in single" "basophil: 1.6" "Low lineage specificity" "Detected in single" "unprognostic (6.27e-2)" "unprognostic (1.02e-1)" "unprognostic (7.76e-2)" "unprognostic (1.03e-2)" "unprognostic (1.09e-1)" "unprognostic (7.92e-2)" "unprognostic (1.71e-7)" "unprognostic (2.14e-1)" "unprognostic (4.57e-2)" 0.1 0.7 0.0 0.0 0.0 0.0 0.3 0.0 0.1 0.7 0.1 0.0 0.0 0.1 0.0 0.0 54.4 0.0 0.0 0.0 0.0 0.0 0.3 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 3.2 0.0 0.0 2.3 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 23.6 40.2 0.2 2.8 0.2 0.1 1.6 0.2 0.6 0.1 0.0 0.0 0.8 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.5 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 49.4 3.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.6 0.0 0.0 0.1 0.1 0.0 0.2 0.1 0.1 0.0 0.2 0.1 0.0 0.2 0.6 0.2 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 UGT1A9 "HLUGP4, LUGP4, UGT1AI" ENSG00000241119 "UDP glucuronosyltransferase family 1 member A9" O60656 2 233671853-233773300 "Cancer-related genes, Enzymes, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 4 "kidney: 169.8" "Group enriched" "Detected in some" 20 "A549: 4.8;RT4: 3.9" "Group enriched" "Detected in some" 157 "liver cancer: 16.1;renal cancer: 16.5" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "unprognostic (2.46e-2)" "unprognostic (3.56e-1)" "prognostic unfavourable (5.04e-5)" "unprognostic (4.26e-2)" "unprognostic (1.60e-1)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 169.8 39.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 UGT2B10 ENSG00000109181 "UDP glucuronosyltransferase family 2 member B10" P36537 4 68815993-68831196 "Enzymes, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 277 "liver: 120.4" "Cell line enriched" "Detected in single" 39 "Hep G2: 15.8" "Cancer enriched" "Detected in single" 296 "liver cancer: 93.8" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045108 Uncertain "HPA045108: " "unprognostic (3.50e-3)" "unprognostic (1.92e-3)" "unprognostic (4.17e-1)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 120.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 15.8 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 UGT2B11 ENSG00000213759 "UDP glucuronosyltransferase family 2 member B11" O75310 4 69199951-69214731 "Enzymes, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enriched" "Detected in some" 10 "breast: 77.4" "Cell line enhanced" "Detected in some" "Hep G2: 1.5;HL-60: 3.0;NB-4: 2.4;RPTEC TERT1: 3.6;U-2197: 1.4" "Group enriched" "Detected in some" 17 "breast cancer: 17.4;liver cancer: 13.1" "Not detected" "Not detected" "Group enriched" "Detected in some" 62 "basophil: 6.8;eosinophil: 5.6" "Lineage enriched" "Detected in single" 68 "granulocytes: 6.8" HPA045108 Uncertain "HPA045108: " "unprognostic (1.12e-1)" "unprognostic (1.18e-3)" "unprognostic (1.49e-1)" "unprognostic (6.53e-2)" "unprognostic (2.26e-2)" "unprognostic (1.65e-1)" "unprognostic (7.84e-3)" "unprognostic (5.47e-1)" "unprognostic (1.32e-1)" "unprognostic (1.51e-3)" 0.1 0.0 0.1 0.1 0.1 0.0 77.4 0.1 0.1 0.1 0.6 0.1 0.1 0.0 0.1 0.1 0.1 0.0 3.3 0.1 0.1 0.0 1.2 7.3 0.1 0.1 0.1 0.1 0.1 0.5 0.0 0.1 0.1 0.1 0.1 0.0 0.1 7.0 0.1 0.1 1.2 0.1 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.9 0.1 0.1 0.1 0.1 0.0 0.0 6.8 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.4 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.5 0.0 3.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.4 0.0 0.0 0.0 0.1 0.0 3.6 0.2 0.0 0.0 0.1 0.3 0.0 0.0 0.0 0.0 0.0 0.0 1.4 0.0 0.0 0.0 0.1 0.6 0.0 0.0 6.8 0.0 5.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.1 UGT2B15 UGT2B8 ENSG00000196620 "UDP glucuronosyltransferase family 2 member B15" P54855 4 68646630-68670628 "Enzymes, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 8 "gallbladder: 22.4;intestine: 50.7;liver: 65.4" "Cell line enhanced" "Detected in some" "A549: 3.2;HL-60: 2.1;RH-30: 1.2;RPMI-8226: 1.1" "Cancer enriched" "Detected in many" 10 "liver cancer: 120.2" "Not detected" "Not detected" "Cell type enhanced" "Detected in single" "naive B-cell: 2.7" "Lineage enhanced" "Detected in single" "B-cells: 2.7" HPA045108 Approved "HPA045108: " "unprognostic (1.40e-1)" "unprognostic (2.25e-1)" "unprognostic (2.22e-2)" "unprognostic (3.86e-1)" "unprognostic (1.94e-1)" "prognostic favourable (9.82e-4)" "unprognostic (6.73e-2)" "unprognostic (3.49e-2)" "unprognostic (7.84e-2)" "unprognostic (5.81e-3)" "unprognostic (2.39e-2)" "unprognostic (5.38e-2)" "prognostic favourable (4.50e-4)" 0.1 0.0 0.1 0.6 0.1 0.0 0.1 0.1 0.1 0.1 48.0 0.1 0.1 5.4 0.1 0.1 0.2 0.0 22.4 0.1 0.1 0.0 0.1 65.4 0.1 0.1 0.1 0.1 0.1 5.3 0.0 0.1 0.1 0.1 0.2 1.6 0.1 0.1 0.1 0.1 0.0 50.7 0.1 0.1 0.1 5.7 0.1 0.1 0.1 0.1 0.1 0.1 0.3 0.1 2.7 0.0 0.9 0.0 0.0 0.0 0.0 0.0 3.2 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.4 0.0 0.1 0.3 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 2.1 0.3 0.0 0.0 0.0 0.0 0.0 0.3 0.3 0.0 0.0 0.0 0.0 0.2 0.0 0.0 1.2 1.1 0.0 0.2 0.1 0.6 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.8 0.2 0.4 0.1 0.5 0.0 0.6 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.7 0.0 0.0 0.0 2.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.1 UGT2B17 ENSG00000197888 "UDP glucuronosyltransferase family 2 member B17" O75795 4 68537184-68568527 "Enzymes, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "intestine: 68.1;liver: 21.6" "Group enriched" "Detected in some" 7 "BEWO: 3.1;NB-4: 3.5;RPMI-8226: 5.1;SH-SY5Y: 2.3;U-2197: 2.1" "Group enriched" "Detected in many" 7 "colorectal cancer: 16.3;liver cancer: 10.1" "Not detected" "Not detected" "Group enriched" "Detected in some" 38 "memory B-cell: 3.3;naive B-cell: 11.9" "Lineage enriched" "Detected in single" 59 "B-cells: 11.9" HPA045108 Supported "HPA045108: " "unprognostic (1.66e-1)" "unprognostic (2.97e-2)" "unprognostic (2.96e-2)" "unprognostic (2.41e-1)" "unprognostic (1.88e-1)" "unprognostic (1.19e-2)" "unprognostic (2.36e-1)" "unprognostic (8.44e-3)" "unprognostic (9.67e-2)" "unprognostic (4.80e-3)" "unprognostic (8.52e-2)" "unprognostic (2.45e-1)" "unprognostic (6.44e-2)" "unprognostic (1.75e-1)" "unprognostic (1.76e-1)" 0.4 0.1 0.4 4.7 0.4 0.0 0.4 0.4 0.4 0.4 55.6 0.4 0.4 54.1 0.4 0.4 0.4 0.1 0.4 0.4 0.4 0.1 0.4 21.6 0.4 0.4 0.4 0.4 0.4 0.4 0.0 0.4 0.4 0.4 0.4 20.7 0.4 0.4 0.4 0.4 0.1 68.1 1.1 0.4 0.4 0.1 0.4 0.4 0.4 0.4 0.4 0.4 0.4 0.4 11.9 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 3.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.4 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 3.5 0.0 0.0 0.0 0.0 5.1 0.2 0.0 0.3 2.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.1 0.0 0.4 0.1 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.2 3.3 0.0 0.0 0.0 11.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.4 0.4 0.4 0.4 0.4 0.1 0.4 0.4 0.4 0.4 UGT2B28 ENSG00000135226 "UDP glucuronosyltransferase family 2 member B28" Q9BY64 4 69280499-69295050 "Enzymes, Predicted intracellular proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 11 "breast: 71.7;salivary gland: 25.6" "Group enriched" "Detected in some" 10 "Daudi: 6.9;NB-4: 6.3" "Cancer enriched" "Detected in single" 8 "breast cancer: 1.9" "Not detected" "Not detected" "Group enriched" "Detected in some" 12 "basophil: 2.5;eosinophil: 4.0" "Lineage enriched" "Detected in single" 14 "granulocytes: 4.0" HPA045108 Uncertain "Intracellular and membrane" "HPA045108: " "unprognostic (1.81e-1)" "unprognostic (1.40e-1)" "unprognostic (7.20e-3)" "unprognostic (1.51e-2)" "unprognostic (4.37e-5)" "unprognostic (9.79e-4)" 0.0 0.0 0.0 0.0 0.0 0.0 71.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 4.4 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 25.6 0.0 0.0 1.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.2 0.1 0.0 0.2 4.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 6.3 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.5 0.0 4.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 UGT2B4 UGT2B11 ENSG00000156096 "UDP glucuronosyltransferase family 2 member B4" P06133 4 69480165-69526014 "Enzymes, Predicted intracellular proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 105 "liver: 175.1" "Cell line enriched" "Detected in some" 9 "RH-30: 10.1" "Cancer enriched" "Detected in some" 96 "liver cancer: 351.5" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "CAB033260, HPA045108" Enhanced "Intracellular and membrane" "CAB033260: AB_2241496, HPA045108: " "unprognostic (7.46e-2)" "unprognostic (1.50e-1)" "unprognostic (9.37e-2)" "unprognostic (1.51e-1)" "unprognostic (2.47e-2)" "unprognostic (1.47e-1)" "unprognostic (9.43e-3)" "unprognostic (3.52e-1)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 1.6 0.0 0.0 0.1 175.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.7 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 10.1 0.1 0.3 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.3 0.0 0.0 0.0 0.1 0.1 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 UGT2B7 UGT2B9 ENSG00000171234 "UDP glucuronosyltransferase family 2 member B7" P16662 4 69051363-69112987 "Enzymes, Predicted intracellular proteins, Predicted membrane proteins" "Lipid metabolism, Steroid metabolism" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 5 "kidney: 125.4;liver: 156.0" "Group enriched" "Detected in some" 5 "EFO-21: 20.5;RPTEC TERT1: 81.6" "Group enriched" "Detected in many" 7 "liver cancer: 116.4;renal cancer: 101.8" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045108 Uncertain "HPA045108: " "unprognostic (1.04e-1)" "unprognostic (1.65e-1)" "prognostic favourable (7.65e-5)" "unprognostic (1.11e-2)" "unprognostic (2.10e-1)" "unprognostic (2.30e-2)" "unprognostic (5.41e-3)" "unprognostic (1.68e-1)" "unprognostic (1.74e-2)" "unprognostic (1.17e-3)" "unprognostic (1.98e-1)" "prognostic favourable (3.79e-4)" "unprognostic (1.08e-2)" "unprognostic (2.55e-1)" "unprognostic (6.23e-3)" "prognostic favourable (5.38e-4)" 0.1 0.1 0.1 0.2 0.1 0.0 0.4 0.1 0.1 3.1 7.9 0.1 2.5 6.4 0.6 4.7 0.1 4.7 1.5 0.1 0.1 0.1 125.4 156.0 0.2 0.1 0.1 0.1 0.6 14.7 0.0 0.1 0.2 0.1 0.3 0.4 0.2 1.0 2.7 0.3 0.2 27.7 0.1 0.1 0.2 0.1 0.6 0.1 0.2 0.1 0.1 0.3 0.3 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 20.5 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 10.4 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 81.6 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 11.3 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 UROD ENSG00000126088 "Uroporphyrinogen decarboxylase" P06132 1 45012147-45015575 "Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Heme biosynthesis, Porphyrin biosynthesis" "Decarboxylase, Lyase" "Disease mutation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell line enhanced" "Detected in all" "K-562: 79.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA027468, HPA028668, HPA030350" Uncertain Supported Nucleoplasm,Cytosol 5200000 "Nucleoplasm, Cytosol" "HPA027468: AB_1858654, HPA028668: AB_10603458, HPA030350: " "unprognostic (5.90e-2)" "unprognostic (2.94e-2)" "unprognostic (2.49e-1)" "unprognostic (9.61e-2)" "unprognostic (7.94e-2)" "unprognostic (1.96e-1)" "prognostic unfavourable (2.48e-4)" "unprognostic (2.31e-2)" "unprognostic (4.76e-2)" "unprognostic (6.75e-2)" "unprognostic (7.72e-3)" "unprognostic (3.92e-1)" "unprognostic (1.24e-1)" "unprognostic (4.68e-2)" "unprognostic (1.41e-1)" "unprognostic (8.73e-2)" "unprognostic (8.12e-2)" 20.7 50.2 23.1 12.2 26.2 67.5 20.7 14.2 28.6 17.7 24.2 16.5 25.9 11.2 27.8 22.6 17.8 20.8 17.4 34.0 21.1 20.3 29.6 58.1 14.3 14.8 21.6 22.9 27.4 18.4 35.9 17.6 25.8 16.2 19.2 12.3 24.3 45.6 19.2 28.8 12.1 13.2 22.9 18.9 16.6 15.0 16.3 11.5 17.2 26.3 23.6 16.0 15.0 13.0 25.7 48.6 20.6 36.3 26.0 27.4 35.6 12.5 8.2 13.2 17.3 22.8 21.5 6.4 15.3 39.6 32.3 24.9 11.8 6.6 8.9 16.2 23.2 6.5 25.1 29.9 22.5 7.9 26.4 46.0 19.0 39.1 26.6 14.0 8.6 22.3 19.0 30.8 25.0 41.4 79.8 9.8 30.8 10.5 9.5 12.1 20.5 29.1 14.4 19.6 12.9 28.1 10.6 14.1 11.1 16.8 12.6 25.9 9.9 14.7 26.8 18.4 14.4 6.3 24.7 10.2 10.9 7.5 28.8 21.3 9.2 17.6 36.3 20.6 19.7 25.8 20.0 25.7 23.8 19.2 48.6 23.7 22.3 20.3 6.6 26.0 15.5 32.4 27.4 35.6 23.1 26.2 14.2 28.6 21.1 20.3 21.6 22.9 16.2 11.5 ZADH2 MGC45594 ENSG00000180011 "Zinc binding alcohol dehydrogenase domain containing 2" Q8N4Q0 18 75195108-75209348 "Enzymes, Predicted intracellular proteins" Oxidoreductase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA021468, HPA053646" Uncertain Approved "Nucleoplasm,Golgi apparatus,Vesicles" Nucleoplasm "Golgi apparatus, Vesicles" "HPA021468: AB_1858932, HPA053646: " "unprognostic (3.22e-2)" "unprognostic (1.03e-2)" "unprognostic (7.14e-2)" "unprognostic (1.13e-1)" "unprognostic (4.79e-1)" "unprognostic (5.11e-3)" "unprognostic (1.15e-1)" "unprognostic (1.49e-1)" "unprognostic (3.62e-3)" "unprognostic (1.42e-1)" "unprognostic (3.05e-2)" "unprognostic (1.48e-1)" "prognostic favourable (1.02e-6)" "unprognostic (3.41e-1)" "unprognostic (1.87e-1)" "prognostic unfavourable (1.94e-4)" "unprognostic (2.23e-1)" 14.1 12.1 15.6 12.5 22.5 12.7 28.1 19.1 24.1 15.5 18.9 10.8 13.6 13.7 12.8 19.0 18.1 13.5 15.7 24.4 17.4 11.3 18.0 23.4 13.3 12.7 12.9 18.4 19.6 19.5 22.4 20.5 26.2 19.3 13.8 21.4 13.5 16.3 14.1 34.5 15.8 24.0 16.9 12.1 15.0 15.5 7.1 11.2 11.2 20.7 15.5 14.5 17.4 15.5 2.7 3.3 12.1 5.2 2.5 4.8 2.3 9.3 6.2 6.6 13.5 10.3 13.4 7.3 16.9 19.7 6.7 8.4 3.8 13.3 6.5 2.7 16.7 12.7 8.2 14.3 4.7 40.6 12.0 14.7 13.7 7.3 7.4 24.7 15.0 14.8 14.3 5.3 12.3 13.7 7.9 24.1 12.7 10.9 6.2 12.2 1.7 14.2 13.3 10.6 21.5 13.0 15.8 12.3 10.1 9.4 9.7 10.7 9.7 12.3 12.1 13.1 10.1 4.1 5.3 3.9 17.1 4.5 8.7 21.5 10.6 1.9 5.0 12.1 4.8 4.2 3.8 2.7 4.1 4.5 3.3 2.5 2.3 3.5 2.7 2.5 5.2 2.5 4.4 2.3 15.6 22.5 19.1 24.1 17.4 11.3 12.9 18.4 19.3 11.2