Gene	"Gene synonym"	Ensembl	"Gene description"	Uniprot	Chromosome	Position	"Protein class"	"Biological process"	"Molecular function"	"Disease involvement"	Evidence	"HPA evidence"	"UniProt evidence"	"NeXtProt evidence"	"MS evidence"	"RNA tissue specificity"	"RNA tissue distribution"	"RNA tissue specificity score"	"RNA tissue specific NX"	"RNA cell line specificity"	"RNA cell line distribution"	"RNA cell line specificity score"	"RNA cell line specific NX"	"RNA cancer specificity"	"RNA cancer distribution"	"RNA cancer specificity score"	"RNA cancer specific FPKM"	"RNA brain regional specificity"	"RNA brain regional distribution"	"RNA brain regional specificity score"	"RNA brain regional specific NX"	"RNA blood cell specificity"	"RNA blood cell distribution"	"RNA blood cell specificity score"	"RNA blood cell specific NX"	"RNA blood lineage specificity"	"RNA blood lineage distribution"	"RNA blood lineage specificity score"	"RNA blood lineage specific NX"	"RNA mouse brain regional specificity"	"RNA mouse brain regional distribution"	"RNA mouse brain regional specificity score"	"RNA mouse brain regional specific pTPM"	"RNA pig brain regional specificity"	"RNA pig brain regional distribution"	"RNA pig brain regional specificity score"	"RNA pig brain regional specific pTPM"	Antibody	"Reliability (IH)"	"Reliability (Mouse Brain)"	"Reliability (IF)"	"Subcellular location"	"Secretome location"	"Blood concentration - Conc. blood IM [pg/L]"	"Blood concentration - Conc. blood MS [pg/L]"	"Subcellular main location"	"Subcellular additional location"	"Antibody RRID"	"Pathology prognostics - Breast cancer"	"Pathology prognostics - Cervical cancer"	"Pathology prognostics - Colorectal cancer"	"Pathology prognostics - Endometrial cancer"	"Pathology prognostics - Glioma"	"Pathology prognostics - Head and neck cancer"	"Pathology prognostics - Liver cancer"	"Pathology prognostics - Lung cancer"	"Pathology prognostics - Melanoma"	"Pathology prognostics - Ovarian cancer"	"Pathology prognostics - Pancreatic cancer"	"Pathology prognostics - Prostate cancer"	"Pathology prognostics - Renal cancer"	"Pathology prognostics - Stomach cancer"	"Pathology prognostics - Testis cancer"	"Pathology prognostics - Thyroid cancer"	"Pathology prognostics - Urothelial cancer"	"Tissue RNA - adipose tissue [NX]"	"Tissue RNA - adrenal gland [NX]"	"Tissue RNA - amygdala [NX]"	"Tissue RNA - appendix [NX]"	"Tissue RNA - basal ganglia [NX]"	"Tissue RNA - bone marrow [NX]"	"Tissue RNA - breast [NX]"	"Tissue RNA - cerebellum [NX]"	"Tissue RNA - cerebral cortex [NX]"	"Tissue RNA - cervix, uterine [NX]"	"Tissue RNA - colon [NX]"	"Tissue RNA - corpus callosum [NX]"	"Tissue RNA - ductus deferens [NX]"	"Tissue RNA - duodenum [NX]"	"Tissue RNA - endometrium 1 [NX]"	"Tissue RNA - epididymis [NX]"	"Tissue RNA - esophagus [NX]"	"Tissue RNA - fallopian tube [NX]"	"Tissue RNA - gallbladder [NX]"	"Tissue RNA - heart muscle [NX]"	"Tissue RNA - hippocampal formation [NX]"	"Tissue RNA - hypothalamus [NX]"	"Tissue RNA - kidney [NX]"	"Tissue RNA - liver [NX]"	"Tissue RNA - lung [NX]"	"Tissue RNA - lymph node [NX]"	"Tissue RNA - midbrain [NX]"	"Tissue RNA - olfactory region [NX]"	"Tissue RNA - ovary [NX]"	"Tissue RNA - pancreas [NX]"	"Tissue RNA - parathyroid gland [NX]"	"Tissue RNA - pituitary gland [NX]"	"Tissue RNA - placenta [NX]"	"Tissue RNA - pons and medulla [NX]"	"Tissue RNA - prostate [NX]"	"Tissue RNA - rectum [NX]"	"Tissue RNA - retina [NX]"	"Tissue RNA - salivary gland [NX]"	"Tissue RNA - seminal vesicle [NX]"	"Tissue RNA - skeletal muscle [NX]"	"Tissue RNA - skin 1 [NX]"	"Tissue RNA - small intestine [NX]"	"Tissue RNA - smooth muscle [NX]"	"Tissue RNA - spinal cord [NX]"	"Tissue RNA - spleen [NX]"	"Tissue RNA - stomach 1 [NX]"	"Tissue RNA - testis [NX]"	"Tissue RNA - thalamus [NX]"	"Tissue RNA - thymus [NX]"	"Tissue RNA - thyroid gland [NX]"	"Tissue RNA - tongue [NX]"	"Tissue RNA - tonsil [NX]"	"Tissue RNA - urinary bladder [NX]"	"Tissue RNA - vagina [NX]"	"Tissue RNA - B-cells [NX]"	"Tissue RNA - dendritic cells [NX]"	"Tissue RNA - granulocytes [NX]"	"Tissue RNA - monocytes [NX]"	"Tissue RNA - NK-cells [NX]"	"Tissue RNA - T-cells [NX]"	"Tissue RNA - total PBMC [NX]"	"Cell RNA - A-431 [NX]"	"Cell RNA - A549 [NX]"	"Cell RNA - AF22 [NX]"	"Cell RNA - AN3-CA [NX]"	"Cell RNA - ASC diff [NX]"	"Cell RNA - ASC TERT1 [NX]"	"Cell RNA - BEWO [NX]"	"Cell RNA - BJ [NX]"	"Cell RNA - BJ hTERT+ [NX]"	"Cell RNA - BJ hTERT+ SV40 Large T+ [NX]"	"Cell RNA - BJ hTERT+ SV40 Large T+ RasG12V [NX]"	"Cell RNA - CACO-2 [NX]"	"Cell RNA - CAPAN-2 [NX]"	"Cell RNA - Daudi [NX]"	"Cell RNA - EFO-21 [NX]"	"Cell RNA - fHDF/TERT166 [NX]"	"Cell RNA - HaCaT [NX]"	"Cell RNA - HAP1 [NX]"	"Cell RNA - HBEC3-KT [NX]"	"Cell RNA - HBF TERT88 [NX]"	"Cell RNA - HDLM-2 [NX]"	"Cell RNA - HEK 293 [NX]"	"Cell RNA - HEL [NX]"	"Cell RNA - HeLa [NX]"	"Cell RNA - Hep G2 [NX]"	"Cell RNA - HHSteC [NX]"	"Cell RNA - HL-60 [NX]"	"Cell RNA - HMC-1 [NX]"	"Cell RNA - HSkMC [NX]"	"Cell RNA - hTCEpi [NX]"	"Cell RNA - hTEC/SVTERT24-B [NX]"	"Cell RNA - hTERT-HME1 [NX]"	"Cell RNA - HUVEC TERT2 [NX]"	"Cell RNA - K-562 [NX]"	"Cell RNA - Karpas-707 [NX]"	"Cell RNA - LHCN-M2 [NX]"	"Cell RNA - MCF7 [NX]"	"Cell RNA - MOLT-4 [NX]"	"Cell RNA - NB-4 [NX]"	"Cell RNA - NTERA-2 [NX]"	"Cell RNA - PC-3 [NX]"	"Cell RNA - REH [NX]"	"Cell RNA - RH-30 [NX]"	"Cell RNA - RPMI-8226 [NX]"	"Cell RNA - RPTEC TERT1 [NX]"	"Cell RNA - RT4 [NX]"	"Cell RNA - SCLC-21H [NX]"	"Cell RNA - SH-SY5Y [NX]"	"Cell RNA - SiHa [NX]"	"Cell RNA - SK-BR-3 [NX]"	"Cell RNA - SK-MEL-30 [NX]"	"Cell RNA - T-47d [NX]"	"Cell RNA - THP-1 [NX]"	"Cell RNA - TIME [NX]"	"Cell RNA - U-138 MG [NX]"	"Cell RNA - U-2 OS [NX]"	"Cell RNA - U-2197 [NX]"	"Cell RNA - U-251 MG [NX]"	"Cell RNA - U-266/70 [NX]"	"Cell RNA - U-266/84 [NX]"	"Cell RNA - U-698 [NX]"	"Cell RNA - U-87 MG [NX]"	"Cell RNA - U-937 [NX]"	"Cell RNA - WM-115 [NX]"	"Blood RNA - basophil [NX]"	"Blood RNA - classical monocyte [NX]"	"Blood RNA - eosinophil [NX]"	"Blood RNA - gdT-cell [NX]"	"Blood RNA - intermediate monocyte [NX]"	"Blood RNA - MAIT T-cell [NX]"	"Blood RNA - memory B-cell [NX]"	"Blood RNA - memory CD4 T-cell [NX]"	"Blood RNA - memory CD8 T-cell [NX]"	"Blood RNA - myeloid DC [NX]"	"Blood RNA - naive B-cell [NX]"	"Blood RNA - naive CD4 T-cell [NX]"	"Blood RNA - naive CD8 T-cell [NX]"	"Blood RNA - neutrophil [NX]"	"Blood RNA - NK-cell [NX]"	"Blood RNA - non-classical monocyte [NX]"	"Blood RNA - plasmacytoid DC [NX]"	"Blood RNA - T-reg [NX]"	"Blood RNA - total PBMC [NX]"	"Brain RNA - amygdala [NX]"	"Brain RNA - basal ganglia [NX]"	"Brain RNA - cerebellum [NX]"	"Brain RNA - cerebral cortex [NX]"	"Brain RNA - hippocampal formation [NX]"	"Brain RNA - hypothalamus [NX]"	"Brain RNA - midbrain [NX]"	"Brain RNA - olfactory region [NX]"	"Brain RNA - pons and medulla [NX]"	"Brain RNA - thalamus [NX]"
ADCK1	FLJ39600	ENSG00000063761	"AarF domain containing kinase 1"	Q86TW2	14	77800083-77935012	"Enzymes, Predicted secreted proteins"		"Kinase, Serine/threonine-protein kinase, Transferase"		"Evidence at protein level"	"Evidence at protein level"	"Evidence at transcript level"	"Evidence at protein level"	"Evidence at protein level"	"Low tissue specificity"	"Detected in all"			"Low cell line specificity"	"Detected in many"			"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low cell type specificity"	"Detected in many"			"Low lineage specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"HPA051012, HPA055014"	Uncertain		Approved	Nucleoplasm	"Secreted - unknown location"			Nucleoplasm		"HPA051012: , HPA055014: "	"unprognostic (6.36e-2)"	"unprognostic (7.09e-2)"	"unprognostic (6.00e-2)"	"unprognostic (1.76e-1)"	"unprognostic (2.24e-1)"	"unprognostic (1.46e-1)"	"prognostic unfavourable (1.70e-4)"	"prognostic favourable (4.11e-5)"	"unprognostic (2.33e-1)"	"unprognostic (1.64e-1)"	"unprognostic (4.57e-3)"	"unprognostic (1.38e-1)"	"prognostic favourable (5.82e-6)"	"unprognostic (6.30e-3)"	"unprognostic (2.06e-1)"	"unprognostic (9.57e-2)"	"unprognostic (4.06e-1)"	7.2	11.0	11.0	7.0	15.2	7.4	6.9	6.8	20.5	5.6	10.3	19.0	7.7	11.2	7.7	10.3	7.7	7.1	9.1	11.1	12.4	10.4	8.8	10.5	6.2	6.0	13.5	9.4	6.6	9.8	11.3	11.3	7.8	15.0	8.2	10.3	13.8	10.6	8.9	13.7	8.5	8.5	10.5	10.6	9.7	7.5	5.5	11.5	10.8	9.1	7.8	7.5	6.9	5.0	4.0	8.9	1.4	7.2	3.4	5.3	3.1	3.3	5.4	3.2	10.8	8.1	4.6	4.3	3.4	5.7	3.1	3.7	2.9	8.0	7.3	5.5	6.0	6.4	17.8	5.4	2.0	4.2	5.6	1.9	3.4	4.8	8.3	2.8	4.1	5.7	10.1	1.2	3.9	4.4	6.9	4.5	4.0	16.8	3.4	5.6	6.4	6.4	5.6	0.5	5.8	4.4	8.5	7.2	4.0	6.6	9.2	4.0	13.3	6.2	3.9	2.9	2.3	5.9	3.0	4.6	5.0	4.1	4.4	4.9	3.7	1.4	4.7	1.3	5.3	7.2	3.5	1.7	2.2	3.1	8.9	4.0	2.5	4.6	0.4	3.4	2.8	7.0	3.7	3.1	11.0	15.2	6.8	20.5	12.4	10.4	13.5	9.4	15.0	11.5
ADCK2	MGC20727	ENSG00000133597	"AarF domain containing kinase 2"	Q7Z695	7	140673153-140696261	"Enzymes, Predicted intracellular proteins, Predicted membrane proteins"		"Kinase, Serine/threonine-protein kinase, Transferase"		"Evidence at protein level"	"Evidence at protein level"	"Evidence at transcript level"	"Evidence at protein level"	"Evidence at protein level"	"Low tissue specificity"	"Detected in all"			"Low cell line specificity"	"Detected in many"			"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low cell type specificity"	"Detected in many"			"Low lineage specificity"	"Detected in all"							"Low region specificity"	"Detected in all"			HPA036036	Approved		Uncertain	Centrosome,Cytosol				"Centrosome, Cytosol"		"HPA036036: AB_10672078"	"unprognostic (2.76e-1)"	"unprognostic (1.79e-1)"	"unprognostic (5.72e-2)"	"unprognostic (5.30e-2)"	"unprognostic (4.03e-3)"	"unprognostic (1.52e-1)"	"unprognostic (3.05e-2)"	"unprognostic (7.48e-2)"	"unprognostic (2.61e-1)"	"unprognostic (7.10e-3)"	"unprognostic (6.81e-3)"	"unprognostic (9.36e-3)"	"prognostic favourable (9.75e-5)"	"unprognostic (1.89e-2)"	"unprognostic (2.00e-1)"	"unprognostic (4.13e-1)"	"unprognostic (2.13e-1)"	12.3	10.6	15.3	11.3	16.6	8.8	13.4	15.4	27.0	12.3	15.1	26.3	13.2	8.8	10.3	11.4	18.0	20.0	10.3	10.2	16.6	18.2	12.3	12.5	12.8	15.6	19.5	13.1	14.5	22.8	21.4	12.7	19.9	18.2	14.4	13.2	10.7	16.8	14.0	12.5	25.8	13.0	10.9	24.0	13.6	13.0	7.6	13.3	20.6	25.1	9.9	16.2	13.4	18.9	8.2	12.0	3.2	5.0	5.1	7.3	2.2	15.9	11.5	2.7	12.7	10.0	11.4	16.4	8.3	10.1	8.7	5.8	10.5	11.3	21.4	12.6	5.8	13.2	13.8	9.4	2.6	15.8	14.2	4.5	4.5	5.1	13.9	3.0	11.3	9.5	28.9	4.9	6.9	7.4	7.9	10.5	3.1	19.9	22.4	7.4	4.0	12.5	17.7	0.1	10.4	4.7	16.0	10.8	7.5	11.4	16.6	11.4	14.7	6.1	7.8	10.9	3.8	18.0	16.0	7.3	11.2	15.8	16.0	12.1	12.9	0.0	3.7	3.2	5.4	5.0	4.9	8.2	4.8	5.3	5.7	4.2	7.3	4.7	0.1	5.1	3.0	12.0	6.0	2.2	15.3	16.6	15.4	27.0	16.6	18.2	19.5	13.1	18.2	13.3
ADCK5	FLJ35454	ENSG00000173137	"AarF domain containing kinase 5"	Q3MIX3	8	144373101-144393242	"Enzymes, Predicted membrane proteins"		"Kinase, Serine/threonine-protein kinase, Transferase"		"Evidence at protein level"	"Evidence at transcript level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Low tissue specificity"	"Detected in all"			"Low cell line specificity"	"Detected in many"			"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low cell type specificity"	"Detected in many"			"Low lineage specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"HPA025692, HPA028679"	Approved		Approved	"Plasma membrane,Cytosol"				"Plasma membrane, Cytosol"		"HPA025692: AB_10599486, HPA028679: AB_10600226"	"unprognostic (6.76e-2)"	"unprognostic (1.66e-1)"	"unprognostic (1.68e-2)"	"unprognostic (8.96e-2)"	"unprognostic (1.68e-2)"	"unprognostic (1.00e-1)"	"unprognostic (2.31e-3)"	"unprognostic (6.45e-2)"	"unprognostic (2.70e-1)"	"unprognostic (4.25e-2)"	"unprognostic (6.60e-2)"	"unprognostic (2.03e-2)"	"unprognostic (1.33e-3)"	"unprognostic (1.39e-2)"	"unprognostic (1.20e-1)"	"unprognostic (3.47e-1)"	"unprognostic (2.90e-2)"	4.1	10.0	4.8	8.9	4.5	4.5	4.3	11.5	9.1	4.6	18.3	2.8	7.6	19.1	5.8	4.2	7.2	4.2	6.3	3.8	3.9	4.1	4.8	6.9	3.7	5.0	3.4	8.4	5.5	5.6	4.7	4.1	3.7	4.5	4.7	4.0	4.6	7.4	4.7	5.6	8.3	17.0	2.7	2.4	6.7	5.6	7.7	3.8	6.8	4.1	4.9	6.1	5.1	5.0	4.7	6.3	2.5	5.4	1.8	4.1	2.8	3.8	4.8	1.0	3.3	0.9	0.8	5.7	3.3	1.8	2.6	0.9	5.2	4.2	1.7	2.3	0.7	5.1	0.2	3.5	0.2	4.3	1.6	4.4	3.6	5.8	2.6	1.0	3.4	1.3	2.1	0.9	0.8	1.8	2.9	3.0	1.5	10.1	3.2	4.4	0.6	3.6	4.2	1.6	3.0	1.7	3.6	0.7	1.8	4.8	3.9	2.7	3.3	3.0	1.2	1.4	5.1	3.5	2.2	1.4	0.4	1.5	3.2	3.8	2.0	1.8	4.2	2.5	2.3	5.4	3.0	1.8	2.8	1.8	6.3	4.7	2.9	1.5	0.7	1.8	5.0	4.0	4.1	2.8	4.8	4.5	11.5	9.1	3.9	4.1	3.4	8.4	4.5	3.8
ALPK1	"FLJ22670, KIAA1527, Lak"	ENSG00000073331	"Alpha kinase 1"	Q96QP1	4	112285509-112442620	"Enzymes, Predicted intracellular proteins, Predicted membrane proteins"	"Immunity, Innate immunity"	"Kinase, Serine/threonine-protein kinase, Transferase"		"Evidence at protein level"	"Evidence at transcript level"	"Evidence at transcript level"	"Evidence at protein level"	"Evidence at protein level"	"Low tissue specificity"	"Detected in all"			"Low cell line specificity"	"Detected in many"			"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Cell type enhanced"	"Detected in many"		"neutrophil: 16.3"	"Low lineage specificity"	"Detected in many"			"Low region specificity"	"Detected in many"							"HPA027435, HPA027443"	Approved		Approved	Centrosome				Centrosome		"HPA027435: AB_10599614, HPA027443: AB_10599421"	"unprognostic (6.24e-2)"	"unprognostic (1.92e-1)"	"unprognostic (9.30e-2)"	"unprognostic (1.69e-2)"	"unprognostic (7.40e-2)"	"unprognostic (5.45e-2)"	"unprognostic (2.55e-2)"	"unprognostic (7.47e-2)"	"unprognostic (2.34e-1)"	"unprognostic (1.38e-1)"	"unprognostic (7.14e-2)"	"unprognostic (2.78e-1)"	"prognostic unfavourable (5.82e-7)"	"unprognostic (1.60e-1)"	"unprognostic (4.17e-2)"	"unprognostic (2.81e-1)"	"prognostic favourable (1.17e-4)"	15.1	10.6	5.3	8.3	7.7	17.3	9.3	1.3	5.9	10.8	9.5	5.8	3.0	4.5	9.8	9.2	8.8	9.2	7.5	6.1	6.1	2.3	10.8	13.4	13.2	11.4	9.7	1.0	17.4	9.7	11.0	14.0	11.5	6.6	14.0	7.8	9.6	10.4	6.8	5.0	11.8	12.1	11.3	16.6	16.2	7.4	4.2	8.5	13.7	12.4	4.7	13.7	13.6	11.6	0.9	3.2	16.3	4.3	0.4	0.8	1.2	1.6	5.0	1.5	0.3	6.5	10.4	2.0	1.9	3.4	2.6	3.2	0.5	7.6	5.0	3.3	3.2	1.1	1.7	3.0	3.8	6.4	1.7	3.6	2.0	0.4	10.5	2.2	2.2	12.9	8.5	3.7	7.8	1.0	0.9	8.8	4.9	3.0	1.2	2.0	0.4	1.2	0.6	1.1	1.6	3.8	1.8	0.5	0.8	1.8	6.5	2.8	2.9	4.0	1.9	2.3	2.1	3.7	1.2	2.2	0.7	4.3	5.7	4.5	2.1	1.3	3.2	1.4	0.2	4.3	0.6	0.8	0.6	0.1	3.2	0.9	0.8	0.6	16.3	0.4	1.9	0.5	0.0	1.2	5.3	7.7	1.3	5.9	6.1	2.3	9.7	1.0	6.6	8.5
ALPK2	HAK	ENSG00000198796	"Alpha kinase 2"	Q86TB3	18	58481247-58628957	"Cancer-related genes, Enzymes, Predicted intracellular proteins"		"Kinase, Serine/threonine-protein kinase, Transferase"	"Cancer-related genes"	"Evidence at protein level"	"Evidence at transcript level"	"Evidence at transcript level"	"Evidence at protein level"	"Evidence at protein level"	"Tissue enhanced"	"Detected in some"		"heart muscle: 35.3;skeletal muscle: 35.3;tongue: 12.4"	"Cell line enhanced"	"Detected in many"		"BJ: 26.0;BJ hTERT+: 15.8;fHDF/TERT166: 23.5;U-138 MG: 13.3"	"Cancer enriched"	"Detected in some"	6	"renal cancer: 7.3"	"Not detected"	"Not detected"			"Cell type enhanced"	"Detected in single"		"non-classical monocyte: 1.8"	"Low lineage specificity"	"Detected in single"			"Region enhanced"	"Detected in single"		"cerebellum: 1.1"	"Low region specificity"	"Detected in many"			"HPA027377, HPA027976, HPA028084, HPA029801"	Uncertain		Approved	Cytosol				Cytosol		"HPA027377: AB_10600635, HPA027976: AB_10611246, HPA028084: AB_10601996, HPA029801: AB_10602006"	"unprognostic (7.35e-2)"	"unprognostic (4.91e-2)"	"unprognostic (1.64e-1)"	"unprognostic (4.60e-3)"	"unprognostic (2.64e-1)"	"unprognostic (8.27e-2)"	"unprognostic (1.22e-1)"	"unprognostic (1.41e-1)"	"unprognostic (3.44e-1)"	"unprognostic (1.06e-1)"	"unprognostic (5.13e-2)"	"unprognostic (1.33e-2)"	"prognostic unfavourable (8.20e-5)"	"unprognostic (5.27e-3)"	"unprognostic (2.50e-1)"	"unprognostic (4.73e-2)"	"unprognostic (3.20e-2)"	0.8	0.0	0.1	2.8	0.1	0.0	0.1	0.1	0.2	0.1	0.1	0.1	0.1	0.0	0.1	0.9	0.8	0.0	0.4	35.3	0.1	0.0	5.2	2.8	0.1	3.3	0.1	0.1	0.1	0.1	0.0	0.1	0.5	0.1	0.1	0.0	0.2	0.4	0.1	35.3	0.3	0.6	0.1	0.1	0.2	1.2	0.6	0.1	5.5	0.3	12.4	7.9	0.5	0.1	0.0	0.5	0.0	1.8	0.0	0.3	0.0	0.0	6.9	0.5	0.0	0.2	1.8	0.1	26.0	15.8	11.0	9.5	1.6	0.0	0.0	2.7	23.5	0.0	0.0	0.0	11.3	5.6	0.0	0.0	2.1	0.9	1.4	0.0	0.0	1.6	0.0	3.3	0.1	0.0	0.0	0.2	7.0	0.0	0.0	0.0	0.1	0.0	0.0	5.7	0.0	0.2	0.0	0.0	0.0	0.2	0.0	0.0	0.0	0.0	0.0	13.3	5.8	1.8	4.4	10.7	9.2	0.0	2.6	0.0	0.0	0.0	0.0	0.0	0.0	0.8	0.0	0.0	0.3	0.1	0.0	0.0	0.0	0.1	0.0	0.0	1.8	0.5	0.1	0.0	0.1	0.1	0.1	0.2	0.1	0.0	0.1	0.1	0.1	0.1
ALPK3	"KIAA1330, MAK, Midori"	ENSG00000136383	"Alpha kinase 3"	Q96L96	15	84816680-84873482	"Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins"		"Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase"	"Cardiomyopathy, Disease mutation"	"Evidence at protein level"	"Evidence at transcript level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Tissue enhanced"	"Detected in many"		"heart muscle: 18.4;skeletal muscle: 47.6"	"Cell line enhanced"	"Detected in some"		"BEWO: 9.2;HDLM-2: 6.9;HUVEC TERT2: 9.9;LHCN-M2: 13.6;NTERA-2: 8.3;RH-30: 24.4"	"Low cancer specificity"	"Detected in many"							"Not detected"	"Not detected"			"Not detected"	"Not detected"			"Low region specificity"	"Detected in single"			"Low region specificity"	"Detected in all"			HPA026558	Uncertain		Approved	Nucleoplasm				Nucleoplasm		"HPA026558: AB_1844774"	"unprognostic (2.69e-2)"	"unprognostic (1.42e-1)"	"unprognostic (2.71e-2)"	"unprognostic (4.61e-2)"	"unprognostic (2.08e-1)"	"unprognostic (6.53e-2)"	"unprognostic (1.44e-3)"	"unprognostic (1.42e-1)"	"unprognostic (1.68e-2)"	"unprognostic (1.82e-1)"	"unprognostic (1.74e-3)"	"unprognostic (1.23e-1)"	"prognostic favourable (3.95e-7)"	"unprognostic (1.76e-2)"	"unprognostic (1.77e-1)"	"unprognostic (2.96e-2)"	"unprognostic (4.87e-2)"	3.7	1.8	0.0	0.0	0.0	0.0	0.7	0.0	0.1	0.5	1.4			0.0	0.1	1.7	0.8	0.2	0.3	18.4	0.0	0.6	1.6	1.3	1.0	0.0	0.1		0.0	2.1	8.8	6.9	0.6		0.4	0.0		0.4	0.2	47.6	0.0	0.2	0.8	0.0	0.0	1.2	0.0			0.6		0.0	0.5	0.0	0.0	0.0	0.0	0.0	0.0	0.3	0.0	1.1	0.1	0.1	0.1	0.2	0.0	9.2	0.0	0.0	0.0	0.0	0.0	4.0	0.0	0.2	0.0	0.7	0.0	0.0	0.0	6.9	1.1	1.1	0.2	0.0	0.1	0.0	0.0	0.9	0.1	0.0	0.0	9.9	0.0	0.0	13.6	0.5	0.0	0.1	8.3	0.0	0.0	24.4	0.1	0.0	2.5	0.0	0.1	0.0	1.3	0.0	0.0	6.0	0.2	0.0	0.0	0.0	0.0	0.2	0.5	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.1	0.0	0.0	0.0	0.3	0.0	0.0	0.0	0.0	0.0	0.0										
ATM	"ATA, ATC, ATD, ATDC, TEL1, TELO1"	ENSG00000149311	"ATM serine/threonine kinase"	Q13315	11	108222484-108369102	"Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins"	"Cell cycle, DNA damage"	"DNA-binding, Kinase, Serine/threonine-protein kinase, Transferase"	"Cancer-related genes, Disease mutation, Neurodegeneration, Tumor suppressor"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Low tissue specificity"	"Detected in all"			"Cell line enhanced"	"Detected in all"		"U-698: 47.4"	"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low cell type specificity"	"Detected in all"			"Low lineage specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"CAB000102, HPA067142"	Supported		Enhanced	Nucleoplasm,Vesicles				"Nucleoplasm, Vesicles"		"CAB000102: , HPA067142: "	"unprognostic (9.77e-2)"	"unprognostic (1.47e-1)"	"unprognostic (3.04e-1)"	"unprognostic (2.36e-1)"	"unprognostic (5.70e-2)"	"unprognostic (2.86e-2)"	"unprognostic (6.32e-3)"	"unprognostic (1.05e-1)"	"unprognostic (8.19e-2)"	"unprognostic (1.63e-1)"	"unprognostic (7.68e-2)"	"unprognostic (6.16e-2)"	"unprognostic (2.17e-3)"	"unprognostic (3.10e-1)"	"unprognostic (7.87e-2)"	"unprognostic (1.21e-1)"	"unprognostic (2.81e-1)"	8.3	10.9	12.7	26.5	19.3	16.8	9.4	17.7	14.4	10.9	8.5	10.9	8.8	6.0	11.2	11.4	6.9	9.5	9.2	9.6	12.4	8.5	7.7	9.5	10.1	33.4	19.6	6.7	20.5	20.7	15.7	29.2	8.8	14.5	9.1	7.9	7.2	15.1	9.8	6.2	8.4	16.5	10.6	23.4	22.6	8.9	6.1	17.9	19.5	10.7	5.1	26.9	10.7	10.7	13.7	6.1	13.5	12.5	7.6	18.5	4.4	2.6	3.8	7.5	4.0	9.8	14.3	1.9	6.0	6.7	3.5	5.8	4.7	6.3	9.4	8.9	4.8	4.0	5.7	5.0	5.4	7.5	3.3	8.5	4.7	4.7	5.1	10.2	9.2	9.2	3.1	5.2	10.2	7.2	8.2	6.4	6.8	1.9	7.0	9.4	6.1	3.8	5.5	5.2	14.8	3.9	5.4	5.1	6.3	6.9	3.2	10.3	4.9	5.8	11.3	8.6	4.8	4.9	5.6	4.3	4.5	47.4	5.7	11.3	9.6	13.5	5.7	3.8	14.9	5.3	10.4	11.1	10.5	11.3	2.7	13.7	18.5	17.9	10.8	7.6	12.5	6.1	5.3	4.4	12.7	19.3	17.7	14.4	12.4	8.5	19.6	6.7	14.5	17.9
ATR	"FRP1, MEC1, SCKL, SCKL1"	ENSG00000175054	"ATR serine/threonine kinase"	Q13535	3	142449235-142578826	"Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins"	"DNA damage, DNA repair"	"DNA-binding, Kinase, Serine/threonine-protein kinase, Transferase"	"Cancer-related genes, Disease mutation, Dwarfism, Mental retardation"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Low tissue specificity"	"Detected in all"			"Low cell line specificity"	"Detected in all"			"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low cell type specificity"	"Detected in many"			"Low lineage specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			HPA054320			Supported	"Nucleoplasm,Golgi apparatus"				Nucleoplasm	"Golgi apparatus"	"HPA054320: "	"unprognostic (1.47e-1)"	"unprognostic (8.90e-2)"	"unprognostic (2.90e-1)"	"unprognostic (4.23e-2)"	"unprognostic (2.25e-2)"	"unprognostic (6.42e-2)"	"prognostic unfavourable (8.39e-5)"	"unprognostic (3.44e-1)"	"unprognostic (1.67e-1)"	"unprognostic (3.02e-1)"	"prognostic unfavourable (1.23e-5)"	"unprognostic (1.94e-1)"	"unprognostic (5.61e-2)"	"unprognostic (1.06e-1)"	"unprognostic (3.55e-1)"	"unprognostic (1.69e-2)"	"unprognostic (1.43e-1)"	10.5	24.3	7.7	11.4	15.9	10.1	14.8	11.3	14.6	10.1	8.5	10.0	10.4	6.0	14.7	16.8	9.4	12.1	9.3	8.8	9.8	7.1	9.6	12.0	10.3	16.0	10.0	8.1	12.3	13.6	18.0	22.5	8.8	12.5	11.0	11.2	9.5	12.5	10.8	7.7	11.2	10.9	9.8	8.8	14.2	9.0	15.3	9.7	19.0	13.8	7.7	15.1	10.9	10.6	5.8	2.8	2.2	4.0	6.7	6.0	0.8	22.5	11.1	7.4	8.4	10.6	11.6	8.8	12.4	7.0	9.3	9.6	5.2	7.2	18.4	12.9	8.8	14.6	10.9	11.5	14.1	5.9	7.2	10.1	8.4	5.0	4.7	16.9	5.7	9.1	6.4	8.8	10.5	9.6	7.0	8.3	9.5	9.9	12.7	7.0	7.1	7.9	10.6	10.8	13.3	9.4	10.5	5.3	5.3	22.9	8.3	8.1	12.1	6.9	12.4	9.5	4.8	12.3	13.3	10.8	6.4	17.1	12.3	6.6	7.5	0.7	2.7	2.2	4.4	4.0	6.0	3.1	3.2	4.2	2.8	5.8	4.1	4.0	1.7	6.7	2.5	2.5	2.4	0.8	7.7	15.9	11.3	14.6	9.8	7.1	10.0	8.1	12.5	9.7
BCKDK		ENSG00000103507	"Branched chain ketoacid dehydrogenase kinase"	O14874	16	31106107-31112791	"Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins"		"Kinase, Transferase"	"Autism, Autism spectrum disorder, Disease mutation"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Low tissue specificity"	"Detected in all"			"Low cell line specificity"	"Detected in all"			"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low cell type specificity"	"Detected in all"			"Group enriched"	"Detected in all"	4	"dendritic cells: 26.8;granulocytes: 26.6;monocytes: 33.0"	"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"HPA017995, HPA056067"	Supported		Supported	Mitochondria				Mitochondria		"HPA017995: AB_1845309, HPA056067: "	"unprognostic (1.37e-1)"	"unprognostic (2.57e-1)"	"unprognostic (6.94e-2)"	"unprognostic (5.20e-2)"	"unprognostic (5.39e-2)"	"unprognostic (3.61e-2)"	"unprognostic (1.01e-1)"	"unprognostic (5.47e-2)"	"unprognostic (1.60e-1)"	"unprognostic (1.90e-1)"	"unprognostic (1.35e-1)"	"unprognostic (3.24e-2)"	"unprognostic (2.66e-3)"	"unprognostic (4.85e-2)"	"unprognostic (3.93e-2)"	"unprognostic (1.00e-1)"	"unprognostic (4.97e-2)"	15.4	29.7	11.9	13.1	15.0	9.4	18.3	18.8	21.3	11.7	14.1	9.6	19.9	11.2	14.8	14.9	14.9	13.8	15.1	39.2	14.2	10.3	21.3	46.5	18.2	32.5	10.7	17.3	15.1	52.4	17.4	8.9	11.4	13.2	14.9	9.9	10.4	33.9	25.7	67.7	21.5	12.2	19.9	15.6	16.0	19.9	11.2	9.3	8.0	11.7	25.9	10.6	15.3	12.0	6.9	26.8	26.6	33.0	6.3	6.8	13.6	18.1	20.4	11.5	17.3	14.2	14.3	12.5	15.8	19.5	24.6	24.1	13.3	12.1	17.0	23.0	19.7	12.6	8.1	27.5	15.9	13.7	25.3	18.4	13.9	24.2	25.1	9.5	16.9	21.0	11.1	21.1	17.6	26.2	9.3	16.1	36.8	30.9	8.8	12.6	9.8	16.5	17.8	16.8	31.3	18.8	12.5	17.8	16.3	12.3	30.3	9.8	18.2	9.2	16.8	18.8	10.9	19.2	13.1	16.8	6.0	6.0	21.3	13.8	17.6	12.2	33.0	23.1	5.7	27.4	5.6	6.9	5.2	4.2	26.8	5.4	4.4	5.0	26.6	6.3	19.3	5.8	6.8	13.6	11.9	15.0	18.8	21.3	14.2	10.3	10.7	17.3	13.2	9.3
COQ8A	"ADCK3, CABC1, COQ8, SCAR9"	ENSG00000163050	"Coenzyme Q8A"	Q8NI60	1	226897536-226987545	"Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins"	"Ubiquinone biosynthesis"	"Kinase, Transferase"	"Disease mutation, Neurodegeneration, Primary mitochondrial disease"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Tissue enriched"	"Detected in all"	4	"skeletal muscle: 216.5"	"Cell line enhanced"	"Detected in many"		"HEK 293: 33.0;RPMI-8226: 30.2"	"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low cell type specificity"	"Detected in all"			"Low lineage specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			HPA061662			Supported	Mitochondria				Mitochondria		"HPA061662: "	"unprognostic (6.37e-3)"	"unprognostic (2.09e-2)"	"unprognostic (2.29e-1)"	"unprognostic (9.06e-2)"	"unprognostic (8.94e-2)"	"unprognostic (2.49e-1)"	"unprognostic (4.42e-2)"	"unprognostic (3.50e-3)"	"unprognostic (1.81e-1)"	"unprognostic (4.02e-1)"	"unprognostic (4.15e-3)"	"unprognostic (8.67e-2)"	"unprognostic (2.40e-2)"	"unprognostic (9.24e-2)"	"unprognostic (2.82e-1)"	"unprognostic (8.88e-2)"	"unprognostic (2.62e-1)"	13.3	25.4	2.8	2.7	4.5	5.3	8.5	14.5	3.9	3.2	7.3	4.1	4.2	6.9	3.6	5.5	7.3	5.0	6.1	41.0	2.7	1.8	3.8	17.7	2.7	4.1	5.0	2.4	7.2	20.3	1.6	1.6	2.0	3.8	6.5	2.0	1.9	7.2	5.0	216.5	4.4	4.4	7.8	2.9	3.5	8.8	3.0	4.7	2.7	4.6	50.2	5.8	10.2	3.5	15.2	9.3	32.3	11.5	9.9	11.8	11.6	3.2	5.8	1.5	4.5	4.7	3.1	23.6	1.5	1.3	2.2	2.9	9.2	5.2	9.5	7.3	1.0	3.7	2.9	3.3	0.5	9.9	33.0	6.6	4.8	15.1	1.0	10.0	4.1	5.9	5.1	1.7	2.3	1.0	11.4	7.8	0.3	4.3	5.8	14.7	6.4	12.0	5.7	7.1	30.2	0.7	2.4	24.3	9.9	3.0	11.8	8.5	6.2	13.6	1.2	2.5	2.3	3.5	5.5	17.6	15.4	5.0	2.3	11.4	2.4	19.7	11.5	32.3	8.7	8.6	8.3	12.1	8.5	7.7	9.3	15.2	11.8	9.0	21.9	9.9	6.5	4.1	10.6	11.6	2.8	4.5	14.5	3.9	2.7	1.8	5.0	2.4	3.8	4.7
COQ8B	"ADCK4, COQ8, FLJ12229"	ENSG00000123815	"Coenzyme Q8B"	Q96D53	19	40691529-40718207	"Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins"		"Kinase, Transferase"	"Disease mutation"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Low tissue specificity"	"Detected in all"			"Low cell line specificity"	"Detected in all"			"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low cell type specificity"	"Detected in all"			"Low lineage specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"HPA027229, HPA027277, HPA027279, HPA028303"	Supported		Enhanced	Mitochondria				Mitochondria		"HPA027229: AB_10600100, HPA027277: AB_10599857, HPA027279: AB_10601219, HPA028303: AB_2672551"	"unprognostic (7.57e-2)"	"unprognostic (9.48e-2)"	"unprognostic (1.61e-1)"	"unprognostic (2.36e-2)"	"unprognostic (2.33e-2)"	"unprognostic (1.19e-1)"	"unprognostic (1.79e-1)"	"unprognostic (4.63e-2)"	"unprognostic (1.85e-1)"	"unprognostic (2.27e-1)"	"unprognostic (2.82e-2)"	"unprognostic (1.48e-1)"	"unprognostic (2.93e-2)"	"unprognostic (6.18e-2)"	"unprognostic (1.46e-1)"	"unprognostic (7.17e-2)"	"unprognostic (2.65e-2)"	13.6	17.8	21.1	13.1	16.4	11.5	10.0	24.1	19.2	13.6	13.6	18.6	14.8	17.9	15.0	13.2	16.6	26.5	16.7	14.7	15.7	10.7	11.8	15.6	12.1	12.2	15.5	12.1	16.3	19.4	12.6	32.7	7.9	13.2	15.1	5.7	12.3	16.8	17.6	10.3	12.9	18.6	16.2	15.6	12.1	17.5	12.5	16.7	16.8	15.5	6.9	13.2	14.8	11.8	12.9	15.0	17.7	15.6	9.7	13.1	10.5	8.2	33.7	6.9	13.3	6.2	6.0	6.4	7.7	8.3	5.8	6.2	10.5	15.0	11.0	14.9	4.4	7.1	4.8	8.6	2.1	13.2	10.0	10.6	20.5	5.8	10.7	3.6	16.5	7.9	9.2	4.2	5.1	6.5	5.6	6.0	4.0	5.0	4.7	4.4	5.3	3.5	7.9	9.7	8.3	10.1	13.9	12.4	10.1	10.3	15.8	16.7	14.2	13.8	6.1	5.0	17.0	3.6	4.5	6.7	5.4	5.6	18.9	4.2	6.9	15.8	15.6	14.6	11.6	15.4	13.1	12.9	9.0	12.4	15.0	11.7	8.9	9.1	17.7	9.7	13.7	8.7	8.8	10.5	21.1	16.4	24.1	19.2	15.7	10.7	15.5	12.1	13.2	16.7
EEF2K	eEF-2K	ENSG00000103319	"Eukaryotic elongation factor 2 kinase"	O00418	16	22206282-22288732	"Enzymes, Predicted intracellular proteins"		"Calmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase"		"Evidence at protein level"	"Evidence at transcript level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Low tissue specificity"	"Detected in all"			"Cell line enhanced"	"Detected in many"		"HaCaT: 3.9;HMC-1: 4.7;NB-4: 4.0"	"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low cell type specificity"	"Detected in some"			"Low lineage specificity"	"Detected in many"			"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"CAB007818, HPA056061"	Approved		Approved	Nucleoplasm				Nucleoplasm		"CAB007818: AB_598150, HPA056061: "	"unprognostic (4.79e-2)"	"unprognostic (6.10e-1)"	"unprognostic (3.89e-2)"	"unprognostic (3.49e-1)"	"unprognostic (1.94e-2)"	"unprognostic (5.09e-3)"	"unprognostic (1.40e-1)"	"unprognostic (2.24e-2)"	"unprognostic (1.74e-1)"	"unprognostic (8.50e-2)"	"unprognostic (2.01e-2)"	"unprognostic (9.07e-3)"	"prognostic unfavourable (2.38e-4)"	"unprognostic (2.86e-1)"	"unprognostic (1.11e-1)"	"unprognostic (1.24e-1)"	"unprognostic (1.80e-1)"	16.8	5.5	5.3	8.6	3.7	7.6	12.4	17.5	4.8	14.3	10.7	1.3	9.4	5.6	13.2	8.3	6.1	8.2	12.5	9.0	3.2	3.3	3.7	5.5	9.2	6.7	2.4	4.9	6.4	8.1	3.3	3.0	6.4	4.9	12.5	4.6	4.4	12.4	20.5	16.2	37.5	5.1	15.5	1.6	6.1	6.4	4.6	3.1	4.0	4.4	11.5	6.7	13.3	14.2	0.7	2.3	2.2	0.9	1.3	1.6	0.1	0.1	0.0	0.0	0.0	1.0	1.3	1.0	0.0	0.0	0.2	0.0	0.7	0.0	0.9	0.4	0.0	3.9	0.6	0.0	0.0	0.3	0.0	1.6	0.7	2.7	0.0	3.7	4.7	0.0	1.0	0.2	0.3	0.2	0.5	3.3	0.0	0.0	0.2	4.0	0.4	0.0	1.0	2.6	0.7	1.1	0.0	1.0	1.5	0.0	0.0	0.4	0.5	1.2	1.3	2.4	0.9	3.6	0.1	0.7	0.3	1.1	2.7	2.7	0.4	1.5	0.8	0.6	0.5	0.9	0.7	0.4	0.3	0.2	0.2	0.7	0.7	0.3	2.2	1.3	0.5	2.3	1.6	0.1	5.3	3.7	17.5	4.8	3.2	3.3	2.4	4.9	4.9	3.1
FASTK	FAST	ENSG00000164896	"Fas activated serine/threonine kinase"	Q14296	7	151076593-151080866	"Enzymes, Predicted intracellular proteins"	Apoptosis	"Kinase, RNA-binding, Serine/threonine-protein kinase, Transferase"		"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Tissue enhanced"	"Detected in all"		"skeletal muscle: 89.5"	"Low cell line specificity"	"Detected in all"			"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low cell type specificity"	"Detected in all"			"Low lineage specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"HPA031621, CAB032539"	Approved		Approved	"Nuclear speckles,Mitochondria"				Mitochondria	"Nuclear speckles"	"CAB032539: AB_2101115, HPA031621: AB_10611966"	"unprognostic (7.67e-2)"	"unprognostic (6.41e-3)"	"prognostic unfavourable (4.73e-4)"	"unprognostic (2.60e-1)"	"unprognostic (1.75e-3)"	"unprognostic (2.03e-3)"	"unprognostic (1.14e-3)"	"unprognostic (1.01e-1)"	"unprognostic (1.24e-1)"	"unprognostic (4.66e-2)"	"prognostic favourable (3.99e-4)"	"unprognostic (3.49e-2)"	"unprognostic (2.79e-2)"	"unprognostic (4.12e-2)"	"unprognostic (1.05e-1)"	"unprognostic (1.09e-1)"	"unprognostic (8.17e-2)"	13.8	16.8	18.8	15.7	19.0	6.4	10.2	19.0	26.4	18.0	20.6	13.4	20.3	21.2	12.4	14.6	20.3	16.7	16.8	35.7	17.6	12.9	17.7	25.6	9.5	10.4	12.0	15.0	14.4	20.7	20.2	21.8	18.5	12.0	16.8	10.6	14.0	21.7	17.9	89.5	14.4	25.8	11.3	9.2	14.9	14.8	10.6	10.9	11.2	16.8	28.1	16.9	17.4	11.8	15.4	26.0	19.7	22.3	13.1	19.0	14.5	15.7	18.4	5.9	14.1	22.0	9.9	9.8	12.7	17.3	10.8	13.0	12.7	13.7	3.7	17.3	17.1	10.3	5.6	15.2	2.9	10.8	10.1	4.6	4.6	10.8	27.9	3.2	10.4	13.0	22.3	12.5	9.2	12.7	6.7	7.9	12.5	31.7	7.7	9.2	9.9	21.7	5.1	7.1	11.8	14.7	10.9	7.0	7.3	16.7	26.0	16.9	14.0	12.6	10.4	13.8	3.0	12.9	11.2	21.2	12.9	2.4	27.5	7.2	15.8	10.5	22.3	19.7	16.4	21.7	17.1	13.7	17.3	16.9	19.4	15.4	19.0	16.3	4.8	13.1	20.8	26.0	18.7	14.5	18.8	19.0	19.0	26.4	17.6	12.9	12.0	15.0	12.0	10.9
MTOR	"FLJ44809, FRAP, FRAP1, FRAP2, RAFT1, RAPT1"	ENSG00000198793	"Mechanistic target of rapamycin kinase"	P42345	1	11106535-11262507	"Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins"	"Biological rhythms"	"Kinase, Serine/threonine-protein kinase, Transferase"	"Cancer-related genes, Disease mutation, Epilepsy, FDA approved drug targets, Mental retardation"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Low tissue specificity"	"Detected in all"			"Low cell line specificity"	"Detected in all"			"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low cell type specificity"	"Detected in many"			"Low lineage specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"CAB069425, HPA071227"	Approved		Approved	Vesicles,Cytosol				"Vesicles, Cytosol"		"CAB069425: , HPA071227: "	"unprognostic (3.18e-1)"	"unprognostic (1.50e-1)"	"unprognostic (1.20e-1)"	"unprognostic (2.45e-3)"	"unprognostic (5.50e-2)"	"unprognostic (2.55e-2)"	"unprognostic (1.39e-1)"	"unprognostic (1.68e-1)"	"unprognostic (1.18e-1)"	"unprognostic (8.24e-3)"	"unprognostic (3.48e-2)"	"unprognostic (1.88e-1)"	"prognostic favourable (1.49e-5)"	"unprognostic (1.27e-1)"	"unprognostic (2.45e-1)"	"unprognostic (6.60e-2)"	"unprognostic (7.55e-2)"	11.3	13.9	18.7	13.0	22.5	12.3	14.9	25.2	25.2	11.3	14.5	18.2	10.4	11.2	13.8	23.6	13.1	10.5	15.7	14.2	14.5	13.6	15.8	19.4	10.8	14.3	14.0	14.4	10.7	16.6	26.5	16.0	12.5	15.5	15.2	17.1	14.4	14.2	15.2	24.6	16.5	13.6	15.2	10.4	15.4	13.1	38.6	13.1	16.6	13.2	9.9	15.7	11.7	10.2	3.9	4.0	3.0	6.4	2.6	5.6	2.3	15.2	13.8	18.7	14.1	22.6	10.8	9.3	12.9	12.4	17.2	17.0	14.2	14.1	16.9	11.1	15.2	18.2	25.2	19.7	22.3	13.5	18.4	22.5	28.6	17.9	14.2	21.9	16.8	13.8	15.0	24.6	25.0	21.8	25.1	14.6	12.0	17.4	15.1	16.7	14.1	13.1	15.2	22.0	11.3	15.2	13.8	18.9	13.8	27.6	14.9	16.9	12.1	13.0	23.2	15.1	13.7	11.5	17.2	14.4	13.4	33.3	10.9	23.7	15.8	0.7	2.9	3.0	5.2	6.4	4.3	3.9	3.0	2.7	4.0	3.4	3.6	3.1	2.0	2.6	3.3	3.1	5.6	2.3	18.7	22.5	25.2	25.2	14.5	13.6	14.0	14.4	15.5	13.1
PDK1		ENSG00000152256	"Pyruvate dehydrogenase kinase 1"	Q15118	2	172555373-172608669	"Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins"	"Carbohydrate metabolism, Glucose metabolism"	"Kinase, Transferase"	"FDA approved drug targets"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Low tissue specificity"	"Detected in all"			"Cell line enhanced"	"Detected in many"		"U-266/70: 31.3;U-87 MG: 32.0"	"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low cell type specificity"	"Detected in many"			"Group enriched"	"Detected in all"	5	"B-cells: 5.9;granulocytes: 16.0;T-cells: 15.8"	"Low region specificity"	"Detected in all"							"CAB017554, HPA027376, HPA059083"	Approved		Approved	Nucleoli,Mitochondria			22000	"Nucleoli, Mitochondria"		"CAB017554: AB_2161138, HPA027376: AB_1855139, HPA059083: "	"unprognostic (2.14e-1)"	"prognostic unfavourable (7.30e-5)"	"unprognostic (1.21e-1)"	"unprognostic (3.94e-2)"	"unprognostic (6.47e-2)"	"unprognostic (1.58e-1)"	"unprognostic (1.02e-2)"	"unprognostic (1.45e-1)"	"unprognostic (9.69e-3)"	"unprognostic (6.44e-2)"	"unprognostic (5.44e-3)"	"unprognostic (1.55e-1)"	"prognostic unfavourable (1.10e-8)"	"unprognostic (1.82e-1)"	"unprognostic (1.94e-1)"	"unprognostic (2.56e-2)"	"unprognostic (5.34e-2)"	9.9	16.2	6.8	11.0	10.5	13.4	16.7	7.1	15.6	7.3	15.3	3.3	2.9	15.5	5.4	8.0	11.2	4.4	5.8	27.6	6.9	5.2	6.8	14.2	6.1	21.4	7.2	5.2	19.5	7.2	3.4	7.5	7.9	7.2	6.5	13.1	7.6	14.1	7.6	9.6	24.7	8.4	5.2	10.7	14.2	12.5	11.0	6.7	10.3	5.1	5.0	20.8	18.0	9.8	5.9	2.3	16.0	2.2	1.4	15.8	6.2	14.1	0.6	3.7	9.1	1.5	2.3	5.2	12.5	10.1	6.3	13.4	3.6	3.0	13.5	6.9	3.8	6.2	2.5	7.8	20.1	2.7	5.0	16.4	3.3	4.2	2.7	8.1	6.1	2.9	2.8	4.3	7.3	3.3	3.4	9.3	8.3	1.4	5.1	10.2	8.9	3.9	5.4	6.0	21.7	3.2	4.6	6.9	7.9	3.2	3.8	4.7	2.4	3.4	3.8	10.0	3.2	5.2	3.3	31.3	18.1	11.1	32.0	5.9	2.0	12.2	2.2	16.0	2.5	1.5	3.0	4.7	4.2	2.8	2.3	5.9	15.8	9.6	8.5	1.4	1.9	0.4	8.0	6.2	6.8	10.5	7.1	15.6	6.9	5.2	7.2	5.2	7.2	6.7
PDK2	PDHK2	ENSG00000005882	"Pyruvate dehydrogenase kinase 2"	Q15119	17	50094737-50112152	"Enzymes, Predicted intracellular proteins"	"Carbohydrate metabolism, Glucose metabolism"	"Kinase, Transferase"		"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Tissue enhanced"	"Detected in all"		"skeletal muscle: 101.0"	"Low cell line specificity"	"Detected in many"			"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low cell type specificity"	"Detected in all"			"Low lineage specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			HPA008287	Supported		Supported	Nucleoplasm,Mitochondria				"Nucleoplasm, Mitochondria"		"HPA008287: AB_1079589"	"unprognostic (2.74e-2)"	"prognostic favourable (5.87e-4)"	"unprognostic (1.16e-1)"	"unprognostic (2.43e-3)"	"unprognostic (1.22e-1)"	"unprognostic (9.63e-3)"	"unprognostic (9.80e-3)"	"unprognostic (8.39e-3)"	"unprognostic (3.19e-2)"	"unprognostic (1.25e-1)"	"unprognostic (1.17e-2)"	"unprognostic (2.21e-1)"	"prognostic favourable (9.59e-5)"	"unprognostic (3.81e-1)"	"unprognostic (2.54e-1)"	"unprognostic (5.33e-1)"	"unprognostic (1.55e-1)"	20.6	26.1	17.2	5.2	27.5	3.2	10.8	53.7	34.4	10.1	16.1	16.1	10.1	15.5	13.1	69.8	12.5	14.4	11.5	51.7	18.2	13.0	33.7	27.8	9.0	5.7	14.6	20.9	27.7	24.1	16.9	7.5	8.6	14.2	12.7	12.4	19.5	14.0	16.5	101.0	10.6	16.5	15.1	9.9	7.8	13.6	7.2	11.4	6.2	15.6	31.4	7.4	13.8	9.4	11.3	20.1	8.9	12.9	16.5	17.4	12.2	6.4	9.4	11.3	10.1	11.9	9.0	1.2	7.1	10.5	10.6	10.3	0.9	7.1	8.2	11.9	19.8	3.1	7.5	2.8	10.5	16.5	10.4	7.3	9.2	6.9	6.4	0.0	8.0	18.9	11.0	6.9	0.5	9.2	2.9	8.2	6.0	8.3	6.1	0.0	2.4	9.1	9.2	25.2	11.1	5.8	5.5	7.5	11.4	10.0	3.2	4.7	18.5	7.3	4.7	12.5	10.3	8.5	5.1	16.2	15.3	4.4	18.3	2.6	8.0	8.9	12.9	6.8	14.0	9.8	11.1	11.1	12.5	14.8	14.2	11.3	14.6	15.0	2.2	16.5	10.5	20.1	17.4	12.2	17.2	27.5	53.7	34.4	18.2	13.0	14.6	20.9	14.2	11.4
PDK3		ENSG00000067992	"Pyruvate dehydrogenase kinase 3"	Q15120	X	24465221-24539837	"Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins"	"Carbohydrate metabolism, Glucose metabolism"	"Kinase, Transferase"	"Charcot-Marie-Tooth disease, Disease mutation, Neurodegeneration, Neuropathy"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Low tissue specificity"	"Detected in all"			"Low cell line specificity"	"Detected in many"			"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low cell type specificity"	"Detected in all"			"Low lineage specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"HPA046583, HPA072492"	Approved		Supported	Nucleoli,Mitochondria				Mitochondria	Nucleoli	"HPA046583: , HPA072492: "	"unprognostic (5.41e-3)"	"unprognostic (5.43e-3)"	"unprognostic (5.35e-3)"	"unprognostic (3.40e-1)"	"unprognostic (4.05e-3)"	"unprognostic (5.38e-2)"	"prognostic unfavourable (2.76e-4)"	"unprognostic (1.51e-1)"	"unprognostic (5.57e-2)"	"unprognostic (1.35e-1)"	"unprognostic (1.39e-2)"	"unprognostic (2.02e-1)"	"unprognostic (1.72e-1)"	"unprognostic (1.02e-1)"	"unprognostic (2.92e-1)"	"unprognostic (2.28e-2)"	"unprognostic (9.43e-3)"	9.6	5.6	5.7	9.8	17.3	16.3	12.8	3.3	23.6	8.0	14.7	5.5	5.6	13.6	7.3	15.7	9.5	13.2	7.0	16.9	12.5	6.8	13.7	11.1	11.2	13.4	6.2	13.7	11.0	7.3	12.8	14.1	7.7	14.9	8.3	10.1	9.9	19.3	5.2	3.9	14.2	15.6	8.6	6.1	17.9	12.7	23.1	4.8	12.5	6.2	4.1	14.9	10.3	9.2	4.5	7.2	36.4	10.9	7.1	11.0	6.7	9.0	4.6	3.9	6.5	0.1	0.0	4.1	2.7	2.4	3.7	6.5	0.4	11.0	9.1	1.8	0.7	2.0	11.3	6.9	9.9	7.8	5.4	4.9	5.3	2.6	1.3	4.1	4.8	0.7	3.0	0.9	0.9	5.5	0.9	13.9	0.5	16.9	7.8	5.4	7.0	5.4	4.0	7.0	13.4	3.2	17.6	2.5	3.2	14.7	6.0	4.5	8.2	1.6	0.1	2.6	3.8	4.8	3.2	8.9	6.8	11.0	7.1	6.4	5.3	9.4	8.9	21.3	7.6	10.9	11.0	4.5	6.2	6.2	7.2	4.1	4.9	5.7	36.4	7.1	10.4	2.3	5.1	6.7	5.7	17.3	3.3	23.6	12.5	6.8	6.2	13.7	14.9	4.8
PDK4		ENSG00000004799	"Pyruvate dehydrogenase kinase 4"	Q16654	7	95583499-95596491	"Enzymes, Predicted intracellular proteins"	"Carbohydrate metabolism, Glucose metabolism"	"Kinase, Transferase"		"Evidence at protein level"	"Evidence at transcript level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Tissue enhanced"	"Detected in many"		"heart muscle: 351.0;skeletal muscle: 497.0"	"Cell line enriched"	"Detected in some"	7	"ASC diff: 104.7"	"Cancer enhanced"	"Detected in all"		"renal cancer: 107.8"	"Low region specificity"	"Detected in all"			"Group enriched"	"Detected in many"	11	"classical monocyte: 14.2;eosinophil: 15.6;intermediate monocyte: 26.1;myeloid DC: 7.1;non-classical monocyte: 15.6"	"Group enriched"	"Detected in many"	11	"dendritic cells: 7.1;granulocytes: 15.6;monocytes: 26.1"	"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in many"			HPA056731	Approved									"HPA056731: "	"unprognostic (3.18e-3)"	"unprognostic (1.98e-1)"	"unprognostic (1.52e-1)"	"unprognostic (1.34e-1)"	"unprognostic (5.15e-2)"	"unprognostic (1.32e-1)"	"unprognostic (1.00e-3)"	"unprognostic (3.47e-1)"	"unprognostic (6.38e-2)"	"unprognostic (2.24e-3)"	"unprognostic (1.87e-2)"	"unprognostic (8.75e-2)"	"unprognostic (2.41e-2)"	"prognostic unfavourable (1.80e-4)"	"unprognostic (9.15e-2)"	"unprognostic (4.20e-2)"	"unprognostic (1.12e-1)"	90.7	41.9	6.9	5.9	14.6	0.4	49.1	2.5	9.1	12.3	30.9	9.0	150.6	13.6	10.7	13.7	29.0	14.7	15.6	351.0	9.2	3.7	27.7	39.5	14.1	6.1	18.2	2.4	46.6	102.9	0.8	8.1	19.4	26.1	29.3	8.4	4.4	8.4	150.6	497.0	10.2	46.2	20.7	13.9	19.0	21.2	10.8	17.4	1.0	13.4	12.3	2.5	23.8	46.4	0.7	7.1	15.6	26.1	1.4	0.0	4.7	0.0	7.8	0.3	2.0	104.7	0.1	0.0	0.0	0.0	0.0	0.0	0.0	2.6	0.0	1.1	0.3	0.0	0.0	0.0	0.0	0.0	0.2	0.0	14.3	0.0	1.0	0.0	0.0	1.1	0.0	0.0	0.0	0.5	0.3	0.0	0.0	0.1	0.0	0.0	0.0	0.4	0.0	0.0	0.0	5.0	0.5	0.1	0.5	0.0	0.6	1.6	0.2	0.2	0.0	0.0	0.1	0.4	0.0	0.0	0.0	0.0	0.3	0.0	0.0	0.1	14.2	15.6	0.0	26.1	0.0	0.1	0.0	0.0	7.1	0.7	0.0	0.0	1.0	1.4	15.6	0.2	0.0	4.7	6.9	14.6	2.5	9.1	9.2	3.7	18.2	2.4	26.1	17.4
PIK3CA	PI3K	ENSG00000121879	"Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha"	P42336	3	179148114-179240093	"Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Predicted intracellular proteins, RAS pathway related proteins"	"Angiogenesis, Phagocytosis"	"Kinase, Serine/threonine-protein kinase, Transferase"	"Cancer-related genes, Disease mutation, FDA approved drug targets, Proto-oncogene"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Low tissue specificity"	"Detected in all"			"Low cell line specificity"	"Detected in all"			"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low cell type specificity"	"Detected in all"			"Low lineage specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"HPA009985, CAB017804"	Approved		Approved	Cytosol				Cytosol		"CAB017804: , HPA009985: AB_1079610"	"unprognostic (1.81e-1)"	"unprognostic (2.77e-1)"	"unprognostic (2.18e-1)"	"unprognostic (2.69e-3)"	"unprognostic (6.49e-3)"	"unprognostic (1.43e-1)"	"unprognostic (2.65e-2)"	"unprognostic (1.00e-2)"	"unprognostic (1.03e-1)"	"unprognostic (2.37e-1)"	"unprognostic (2.57e-3)"	"unprognostic (5.21e-2)"	"unprognostic (4.50e-2)"	"unprognostic (1.16e-2)"	"unprognostic (2.48e-1)"	"unprognostic (9.74e-2)"	"unprognostic (3.82e-2)"	20.1	12.3	13.7	11.5	13.4	25.7	22.4	17.1	24.5	12.9	14.0	5.2	5.7	6.5	15.3	7.9	11.6	11.1	13.2	14.2	18.4	9.7	11.7	10.8	13.2	13.8	9.8	15.7	15.4	9.2	24.7	11.6	16.5	16.3	10.7	8.9	7.2	10.9	10.9	15.2	12.0	10.5	12.8	14.4	16.2	10.6	9.3	9.8	29.6	11.0	7.3	13.9	15.1	15.7	6.2	2.6	7.8	3.8	2.4	5.0	1.1	14.4	4.9	7.9	7.3	18.7	21.8	5.7	9.2	12.5	9.1	14.4	4.2	10.7	13.2	15.8	11.0	5.9	6.4	8.0	13.2	22.0	5.7	18.1	5.3	3.7	8.9	10.1	10.3	13.7	8.5	10.0	11.5	13.0	9.0	14.7	13.0	5.7	7.7	9.1	6.2	6.7	11.8	8.0	15.8	7.2	8.8	4.4	7.6	10.0	8.9	12.0	14.9	8.7	13.8	8.6	5.6	13.5	9.2	7.1	10.1	23.7	7.7	7.6	5.0	2.1	3.8	1.6	5.0	2.9	3.9	5.8	4.2	2.8	2.2	6.2	4.6	3.8	7.8	2.4	3.0	2.6	4.1	1.1	13.7	13.4	17.1	24.5	18.4	9.7	9.8	15.7	16.3	9.8
PIK3CG		ENSG00000105851	"Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma"	P48736	7	106865278-106907145	"Cancer-related genes, Enzymes, Predicted intracellular proteins"	"Angiogenesis, Chemotaxis, Endocytosis, Immunity, Inflammatory response"	"Kinase, Serine/threonine-protein kinase, Transferase"	"Cancer-related genes"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Group enriched"	"Detected in many"	4	"blood: 24.5;bone marrow: 27.8;lymphoid tissue: 40.8"	"Cell line enhanced"	"Detected in some"		"Daudi: 12.2;HMC-1: 15.2;Karpas-707: 12.6;MOLT-4: 23.0;U-266/70: 30.9;U-937: 21.8"	"Low cancer specificity"	"Detected in many"			"Low region specificity"	"Detected in many"			"Low cell type specificity"	"Detected in all"			"Low lineage specificity"	"Detected in all"			"Low region specificity"	"Detected in many"			"Low region specificity"	"Detected in all"			HPA069976	Enhanced		Supported	"Plasma membrane,Cytosol"				"Plasma membrane"	Cytosol	"HPA069976: "	"unprognostic (8.34e-2)"	"unprognostic (2.01e-2)"	"unprognostic (1.44e-2)"	"unprognostic (1.71e-2)"	"unprognostic (3.20e-2)"	"unprognostic (3.82e-3)"	"unprognostic (3.02e-1)"	"unprognostic (6.77e-2)"	"unprognostic (1.16e-1)"	"unprognostic (7.06e-3)"	"unprognostic (1.15e-1)"	"unprognostic (1.97e-1)"	"unprognostic (1.77e-2)"	"unprognostic (9.08e-2)"	"unprognostic (1.23e-1)"	"unprognostic (5.38e-1)"	"unprognostic (5.24e-2)"	5.0	1.8	2.2	16.0	3.1	27.8	2.3	0.8	1.7	1.7	4.1	2.7	0.0	2.8	1.7	2.0	2.0	1.8	3.5	1.7	1.7	1.5	1.9	1.5	4.3	13.1	3.0	1.0	1.7	1.5	0.6	1.4	2.0	2.5	2.2	2.6	1.9	3.1	0.5	1.1	1.3	6.1	1.9	6.4	17.4	2.5	7.6	3.0	40.8	2.3	0.9	21.2	4.1	1.5	6.2	5.6	14.2	24.5	5.3	5.6	3.6	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	12.2	1.2	0.0	0.0	0.0	0.0	0.0	0.1	0.0	7.5	0.0	0.0	0.0	11.9	15.2	0.0	0.0	0.0	0.0	4.7	8.5	12.6	0.0	0.0	23.0	4.6	0.0	0.0	6.1	0.0	8.1	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	8.1	1.2	0.0	0.1	0.0	0.0	30.9	0.0	11.5	0.0	21.8	2.9	4.6	3.4	14.2	5.6	10.6	5.1	4.7	2.6	4.2	5.6	6.2	2.8	3.8	13.9	5.3	24.5	4.9	2.6	3.6	2.2	3.1	0.8	1.7	1.7	1.5	3.0	1.0	2.5	3.0
PRKDC	"DNA-PKcs, DNAPK, DNPK1, HYRC, HYRC1, p350, XRCC7"	ENSG00000253729	"Protein kinase, DNA-activated, catalytic polypeptide"	P78527	8	47773108-47960183	"Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins"	"Biological rhythms, DNA damage, DNA recombination, DNA repair, Immunity, Innate immunity"	"DNA-binding, Kinase, Serine/threonine-protein kinase, Transferase"	"Cancer-related genes, Disease mutation, SCID"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Low tissue specificity"	"Detected in all"			"Low cell line specificity"	"Detected in all"			"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low cell type specificity"	"Detected in all"			"Low lineage specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"CAB005167, HPA035174"	Supported		Enhanced	Nucleoplasm			1100000	Nucleoplasm		"CAB005167: AB_2172845, HPA035174: "	"unprognostic (3.14e-2)"	"unprognostic (3.02e-3)"	"unprognostic (1.56e-2)"	"prognostic unfavourable (1.03e-4)"	"unprognostic (8.95e-2)"	"unprognostic (1.34e-1)"	"unprognostic (7.70e-3)"	"unprognostic (5.74e-2)"	"unprognostic (1.12e-2)"	"unprognostic (1.60e-2)"	"unprognostic (7.76e-3)"	"unprognostic (7.77e-2)"	"unprognostic (2.84e-2)"	"unprognostic (2.32e-1)"	"unprognostic (2.20e-1)"	"unprognostic (6.76e-3)"	"unprognostic (2.15e-2)"	21.3	20.5	16.0	22.3	22.0	27.4	30.2	16.5	23.1	19.6	20.6	17.3	18.1	12.0	26.2	14.5	27.4	24.4	13.0	21.1	20.8	15.2	16.7	18.4	17.0	33.6	16.6	18.2	24.6	23.8	33.4	29.4	20.5	17.3	17.9	20.3	17.8	17.9	17.8	34.0	23.9	18.4	27.0	20.3	24.4	19.1	20.5	15.9	44.4	20.8	15.9	27.9	21.3	19.1	17.0	13.9	7.1	11.5	11.5	11.3	2.3	32.4	27.8	27.1	25.7	16.9	17.9	11.5	13.8	13.6	19.5	19.2	18.1	10.7	31.0	12.0	16.9	18.5	35.8	18.9	30.6	6.8	22.2	60.9	25.0	22.2	7.3	23.1	12.7	12.9	6.2	30.7	32.2	20.0	40.5	13.1	21.4	15.2	32.6	19.1	29.8	8.4	16.0	21.3	10.9	9.8	28.0	13.6	17.3	42.6	13.9	13.4	19.9	16.0	23.2	25.5	21.7	20.1	27.7	11.5	14.6	44.6	14.4	26.3	20.6	6.7	8.1	3.5	8.7	6.3	10.9	12.6	10.8	8.8	5.9	17.0	11.3	10.3	7.1	11.5	11.5	13.9	7.4	2.3	16.0	22.0	16.5	23.1	20.8	15.2	16.6	18.2	17.3	15.9
RIOK1	"AD034, bA288G3.1, FLJ30006, RRP10"	ENSG00000124784	"RIO kinase 1"	Q9BRS2	6	7389496-7418037	"Enzymes, Predicted intracellular proteins"	"Ribosome biogenesis"	"Hydrolase, Kinase, Serine/threonine-protein kinase, Transferase"		"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Low tissue specificity"	"Detected in all"			"Low cell line specificity"	"Detected in all"			"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low cell type specificity"	"Detected in all"			"Low lineage specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"HPA017866, HPA051446"	Enhanced		Approved	"Nucleoli,Nuclear speckles,Cytosol"				"Nucleoli, Nuclear speckles"	Cytosol	"HPA017866: , HPA051446: "	"unprognostic (2.33e-2)"	"unprognostic (1.24e-1)"	"unprognostic (2.38e-1)"	"unprognostic (1.03e-2)"	"unprognostic (1.16e-1)"	"unprognostic (1.51e-1)"	"prognostic unfavourable (3.41e-5)"	"unprognostic (2.23e-1)"	"prognostic unfavourable (4.43e-4)"	"unprognostic (3.45e-2)"	"unprognostic (1.47e-1)"	"unprognostic (1.87e-1)"	"prognostic unfavourable (5.85e-5)"	"unprognostic (2.33e-1)"	"unprognostic (2.09e-1)"	"unprognostic (6.12e-3)"	"unprognostic (2.59e-2)"	13.8	10.6	7.7	13.2	13.0	17.5	13.1	12.2	13.5	12.7	11.6	7.3	4.0	7.3	15.4	6.0	15.6	12.3	8.5	11.8	8.0	8.1	8.7	11.7	10.1	14.2	11.6	9.4	13.8	15.3	7.7	17.8	13.9	13.3	10.7	9.6	7.2	10.2	10.3	18.8	12.5	9.9	15.5	9.4	14.4	10.3	21.3	9.2	19.2	10.1	14.7	16.8	10.9	12.6	15.4	14.9	7.7	11.1	18.6	15.0	8.2	7.5	4.4	7.1	16.7	11.1	9.1	10.9	9.5	6.4	8.9	7.4	12.8	3.9	19.7	16.9	7.7	7.7	17.9	7.6	11.4	13.0	19.3	10.5	7.1	13.7	9.4	30.2	13.8	6.7	10.6	9.6	19.8	7.8	26.8	4.6	8.3	9.9	20.5	14.3	15.3	10.4	15.8	9.3	21.4	5.0	7.4	23.7	11.7	8.0	4.8	13.8	7.3	10.0	7.8	9.8	7.4	6.4	14.3	6.4	12.1	29.3	3.0	15.6	14.9	7.7	8.5	5.9	11.5	11.1	13.8	15.2	11.9	12.1	14.9	15.4	13.7	15.0	1.7	18.6	9.7	12.4	11.3	8.2	7.7	13.0	12.2	13.5	8.0	8.1	11.6	9.4	13.3	9.2
RIOK2	FLJ11159	ENSG00000058729	"RIO kinase 2"	Q9BVS4	5	97160867-97183260	"Enzymes, Plasma proteins, Predicted intracellular proteins"	"Cell cycle, Ribosome biogenesis"	"Kinase, Serine/threonine-protein kinase, Transferase"		"Evidence at protein level"	"Evidence at transcript level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Low tissue specificity"	"Detected in all"			"Low cell line specificity"	"Detected in all"			"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low cell type specificity"	"Detected in all"			"Low lineage specificity"	"Detected in all"											HPA005681	Uncertain		Approved	"Plasma membrane,Cytosol"				Cytosol	"Plasma membrane"	"HPA005681: AB_1856286"	"unprognostic (6.36e-2)"	"unprognostic (1.21e-1)"	"unprognostic (1.13e-2)"	"unprognostic (8.04e-2)"	"unprognostic (1.38e-1)"	"unprognostic (4.51e-2)"	"unprognostic (2.71e-3)"	"unprognostic (3.08e-1)"	"unprognostic (3.90e-2)"	"unprognostic (1.11e-1)"	"unprognostic (8.76e-2)"	"unprognostic (6.63e-2)"	"unprognostic (1.26e-3)"	"unprognostic (3.60e-1)"	"unprognostic (9.98e-2)"	"unprognostic (1.43e-2)"	"unprognostic (1.39e-2)"	22.2	20.1	14.8	17.1	17.5	24.4	19.7	26.3	18.6	19.1	17.0	8.9	14.0	17.3	17.5	17.1	17.0	15.0	10.7	19.6	15.7	13.4	21.0	23.6	13.3	17.6	20.0	11.1	20.7	21.5	15.1	37.5	15.8	19.7	19.5	17.3	10.3	18.7	16.6	24.9	13.3	20.2	16.3	20.7	22.5	16.4	14.8	18.6	25.8	21.7	20.7	17.4	20.7	21.0	15.2	17.8	9.4	18.7	17.8	24.1	13.5	8.8	10.4	9.7	18.8	12.8	14.0	15.5	22.3	13.8	15.8	21.0	14.2	15.6	19.6	25.4	10.0	10.5	16.5	13.0	21.7	13.8	9.1	9.8	20.1	19.8	11.5	18.6	13.8	9.2	10.2	19.3	19.6	12.8	14.8	12.7	18.1	14.8	21.7	22.2	11.5	11.2	24.5	18.9	28.8	12.4	8.1	12.1	9.0	13.5	14.0	15.3	14.7	17.7	13.7	20.3	14.1	16.1	24.2	12.5	16.2	44.0	12.1	19.1	18.4	7.0	16.0	9.4	16.3	18.7	22.3	15.2	20.7	17.8	17.8	11.0	22.5	24.1	3.2	17.8	13.4	17.8	18.5	13.5	14.8	17.5	26.3	18.6	15.7	13.4	20.0	11.1	19.7	18.6
RIOK3	SUDD	ENSG00000101782	"RIO kinase 3"	O14730	18	23452823-23486603	"Enzymes, Predicted intracellular proteins"	"Antiviral defense, Immunity, Innate immunity, Ribosome biogenesis"	"Kinase, Serine/threonine-protein kinase, Transferase"		"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Low tissue specificity"	"Detected in all"			"Low cell line specificity"	"Detected in all"			"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low cell type specificity"	"Detected in all"			"Low lineage specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"HPA001620, HPA024184"	Approved		Approved	"Golgi apparatus,Plasma membrane,Centriolar satellite,Cytosol"				"Plasma membrane, Cytosol"	"Golgi apparatus, Centriolar satellite"	"HPA001620: AB_1079815, HPA024184: AB_1856289"	"unprognostic (7.99e-2)"	"unprognostic (1.71e-2)"	"unprognostic (2.39e-1)"	"unprognostic (3.03e-2)"	"unprognostic (1.05e-1)"	"unprognostic (7.48e-2)"	"unprognostic (8.98e-3)"	"unprognostic (1.01e-1)"	"unprognostic (5.10e-2)"	"unprognostic (4.20e-1)"	"prognostic unfavourable (4.10e-4)"	"prognostic unfavourable (5.80e-4)"	"unprognostic (3.90e-2)"	"unprognostic (1.46e-1)"	"unprognostic (5.44e-2)"	"unprognostic (1.39e-1)"	"unprognostic (2.71e-2)"	10.1	8.7	6.9	11.7	7.7	52.4	10.9	8.9	10.1	14.7	21.4	8.5	5.9	15.6	8.8	9.3	41.0	7.8	10.7	11.5	6.1	5.5	10.5	19.9	10.1	10.7	9.1	6.2	7.6	10.7	7.5	11.6	21.4	11.6	6.8	14.7	6.0	14.9	7.0	40.0	13.3	36.5	15.2	10.5	8.9	12.9	22.7	7.6	11.1	7.3	16.0	16.5	13.7	21.5	11.7	11.0	21.7	21.5	8.3	11.2	10.0	14.7	5.8	6.0	7.8	11.0	12.3	10.9	14.8	10.9	10.5	10.1	6.6	15.9	10.2	19.4	16.4	19.3	10.2	16.8	16.2	10.1	4.2	9.5	10.8	8.3	27.5	26.7	8.3	14.7	32.0	18.6	25.8	14.5	13.7	12.9	15.7	7.8	9.2	4.4	5.6	11.6	10.4	12.6	12.4	12.0	19.3	14.0	10.1	18.9	8.6	10.8	7.6	14.5	22.9	17.3	4.3	7.6	9.6	23.2	19.6	15.2	10.2	12.4	12.9	21.7	13.5	8.0	9.1	19.6	6.9	8.2	7.6	7.9	11.0	11.7	6.1	6.9	9.3	8.3	21.5	5.1	11.2	10.0	6.9	7.7	8.9	10.1	6.1	5.5	9.1	6.2	11.6	7.6
SMG1	"ATX, KIAA0421, LIP"	ENSG00000157106	"SMG1, nonsense mediated mRNA decay associated PI3K related kinase"	Q96Q15	16	18804853-18926454	"Enzymes, Predicted intracellular proteins"	"DNA damage, DNA repair, Nonsense-mediated mRNA decay"	"Kinase, Serine/threonine-protein kinase, Transferase"		"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Low tissue specificity"	"Detected in all"			"Low cell line specificity"	"Detected in all"			"Low cancer specificity"	"Detected in all"							"Low cell type specificity"	"Detected in all"			"Low lineage specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"HPA006870, HPA031623, HPA073972"	Approved		Supported	Nucleoplasm				Nucleoplasm		"HPA006870: AB_1079725, HPA031623: , HPA073972: "	"unprognostic (6.34e-2)"	"unprognostic (5.88e-2)"	"unprognostic (5.98e-2)"	"unprognostic (2.66e-1)"	"unprognostic (2.44e-2)"	"unprognostic (1.35e-2)"	"unprognostic (1.03e-1)"	"unprognostic (2.28e-1)"	"unprognostic (1.22e-1)"	"unprognostic (2.42e-1)"	"unprognostic (8.32e-3)"	"unprognostic (7.28e-2)"	"unprognostic (1.05e-1)"	"unprognostic (2.61e-2)"	"unprognostic (1.15e-1)"	"unprognostic (3.17e-2)"	"unprognostic (2.45e-2)"	4.7	3.0	2.1	4.5	3.5	11.7	6.2	13.2	3.0	4.4	4.5			3.1	5.4	5.1	5.5	4.0	3.0	4.5	2.3	2.2	4.6	5.4	4.1	6.2	2.3		6.3	4.5	7.2	3.9	3.1		4.2	5.0		4.7	3.3	21.1	14.4	5.0	3.9	3.4	4.5	4.3	4.0			6.0		5.8	5.2	4.9	7.1	4.6	19.1	5.6	2.3	6.1	1.0	23.2	15.6	14.7	10.4	16.9	17.9	10.9	10.9	10.7	11.9	13.3	13.7	8.6	32.1	15.7	15.1	13.3	16.9	9.5	19.0	20.6	10.6	14.6	13.7	17.5	13.7	19.6	11.6	10.5	16.1	24.5	29.6	16.6	22.4	17.9	13.1	12.4	13.5	11.8	15.7	9.0	15.7	19.8	11.0	10.2	18.3	13.4	10.2	16.9	11.5	11.9	9.2	12.5	21.0	17.9	12.0	11.0	16.1	9.2	11.9	21.2	11.9	15.3	10.6	19.1	2.5	3.4	6.1	2.8	2.9	3.7	4.0	4.3	2.5	7.1	5.4	4.7	7.6	2.3	5.6	4.6	3.7	1.0										
TRPM6	"CHAK2, FLJ22628, HOMG, HSH"	ENSG00000119121	"Transient receptor potential cation channel subfamily M member 6"	Q9BX84	9	74722495-74888094	"Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters, Voltage-gated ion channels"	"Calcium transport, Ion transport, Transport"	"Calcium channel, Ion channel, Kinase, Serine/threonine-protein kinase, Transferase"	"Disease mutation, Primary hypomagnesemia"	"Evidence at protein level"	"Evidence at transcript level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Tissue enhanced"	"Detected in many"		"blood: 16.1;intestine: 19.5"	"Cell line enhanced"	"Detected in some"		"BEWO: 7.5;HeLa: 4.4;Karpas-707: 2.5;RT4: 7.2;U-266/70: 2.7"	"Cancer enhanced"	"Detected in some"		"testis cancer: 1.8"	"Low region specificity"	"Detected in many"			"Group enriched"	"Detected in some"	6	"basophil: 16.1;neutrophil: 6.6"	"Lineage enriched"	"Detected in single"	30	"granulocytes: 16.1"	"Low region specificity"	"Detected in single"			"Low region specificity"	"Detected in all"														"unprognostic (3.95e-2)"	"unprognostic (1.46e-1)"	"unprognostic (1.76e-1)"	"unprognostic (1.65e-1)"	"unprognostic (7.80e-2)"	"unprognostic (9.20e-2)"	"unprognostic (1.59e-2)"	"unprognostic (1.72e-1)"	"unprognostic (2.82e-1)"	"unprognostic (1.84e-1)"	"unprognostic (5.72e-4)"	"unprognostic (1.58e-1)"	"unprognostic (1.71e-2)"	"unprognostic (8.10e-2)"	"unprognostic (7.54e-2)"	"unprognostic (1.89e-2)"	"unprognostic (2.11e-2)"	2.9	0.0	1.3	0.5	1.2	2.5	1.1	1.3	1.2	0.8	13.3	0.2	1.0	7.2	0.4	0.2	0.6	0.4	1.0	0.5	1.9	1.2	3.1	0.2	1.5	0.2	2.6	0.0	0.4	0.2	3.8	4.9	0.2	1.6	1.7	17.5	0.4	1.1	0.0	1.6	0.8	19.5	0.7	5.0	3.9	0.2	1.7	0.5	1.6	0.3	1.1	2.1	0.5	0.6	0.3	0.3	16.1	0.1	0.5	0.1	0.0	0.0	1.6	0.2	0.2	0.0	0.0	7.5	0.1	0.0	0.0	0.1	2.1	0.2	0.6	0.0	0.1	0.3	0.5	0.5	0.0	0.1	0.2	0.2	4.4	0.3	0.1	0.1	0.2	0.3	0.2	0.0	0.0	0.2	0.0	2.5	0.1	0.9	0.0	0.1	0.6	0.2	0.0	0.0	0.3	0.0	7.2	0.3	0.0	0.0	0.1	0.1	0.3	0.0	0.0	0.2	1.1	0.2	0.0	2.7	0.0	0.2	0.1	0.1	0.3	16.1	0.1	1.9	0.1	0.1	0.0	0.1	0.1	0.1	0.0	0.3	0.1	0.1	6.6	0.5	0.1	0.3	0.0	0.0	1.3	1.2	1.3	1.2	1.9	1.2	2.6	0.0	1.6	0.5
TRPM7	"CHAK1, LTRPC7, TRP-PLIK"	ENSG00000092439	"Transient receptor potential cation channel subfamily M member 7"	Q96QT4	15	50552473-50686815	"Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters, Voltage-gated ion channels"	"Calcium transport, Ion transport, Necrosis, Transport"	"Calcium channel, Ion channel, Kinase, Serine/threonine-protein kinase, Transferase"	"Amyotrophic lateral sclerosis, Neurodegeneration, Parkinsonism"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Tissue enhanced"	"Detected in all"		"parathyroid gland: 91.8"	"Cell line enhanced"	"Detected in all"		"U-2197: 49.9"	"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low cell type specificity"	"Detected in all"			"Low lineage specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"HPA035522, HPA052173"	Enhanced		Approved	"Vesicles,Plasma membrane,Cytosol"				"Plasma membrane"	"Vesicles, Cytosol"	"HPA035522: , HPA052173: "	"unprognostic (3.14e-2)"	"unprognostic (1.86e-1)"	"unprognostic (1.58e-1)"	"unprognostic (1.42e-2)"	"unprognostic (1.89e-1)"	"unprognostic (1.60e-2)"	"unprognostic (1.85e-2)"	"unprognostic (2.59e-2)"	"unprognostic (5.46e-3)"	"unprognostic (2.64e-1)"	"unprognostic (2.91e-1)"	"unprognostic (1.59e-2)"	"unprognostic (3.20e-2)"	"unprognostic (2.08e-1)"	"unprognostic (7.59e-2)"	"unprognostic (9.45e-2)"	"unprognostic (1.97e-1)"	13.3	10.8	6.6	14.7	9.0	12.8	12.1	19.5	9.3	11.8	11.7	8.1	9.7	9.9	16.5	10.7	9.4	11.0	8.2	19.1	5.5	4.9	16.0	20.0	10.8	10.6	12.4	5.2	16.6	11.6	91.8	14.6	14.3	10.2	9.7	10.3	28.6	11.5	13.5	10.8	11.7	12.8	12.8	9.8	11.1	10.3	6.9	10.0	14.5	12.6	6.9	12.6	12.9	12.3	7.0	4.7	4.4	3.4	5.7	7.6	2.0	8.3	8.3	7.0	7.7	20.2	15.2	8.5	10.6	14.7	6.7	8.9	11.4	4.6	18.2	5.2	12.2	14.1	9.3	7.8	9.7	10.1	5.6	14.5	12.8	6.0	18.4	15.0	11.3	14.1	9.2	7.6	14.4	5.4	16.4	14.0	12.2	13.1	9.6	7.3	5.3	5.1	10.6	9.7	8.9	9.4	19.8	5.8	7.4	7.3	11.6	14.2	7.3	16.3	8.2	10.7	5.1	49.9	12.1	9.5	21.0	17.5	11.7	30.7	9.9	3.8	3.4	3.9	6.6	3.2	7.6	5.6	4.8	4.4	3.7	7.0	4.4	5.2	4.4	5.7	3.2	4.7	4.8	2.0	6.6	9.0	19.5	9.3	5.5	4.9	12.4	5.2	10.2	10.0