Gene "Gene synonym" Ensembl "Gene description" Uniprot Chromosome Position "Protein class" "Biological process" "Molecular function" "Disease involvement" Evidence "HPA evidence" "UniProt evidence" "NeXtProt evidence" "MS evidence" "RNA tissue specificity" "RNA tissue distribution" "RNA tissue specificity score" "RNA tissue specific NX" "RNA cell line specificity" "RNA cell line distribution" "RNA cell line specificity score" "RNA cell line specific NX" "RNA cancer specificity" "RNA cancer distribution" "RNA cancer specificity score" "RNA cancer specific FPKM" "RNA brain regional specificity" "RNA brain regional distribution" "RNA brain regional specificity score" "RNA brain regional specific NX" "RNA blood cell specificity" "RNA blood cell distribution" "RNA blood cell specificity score" "RNA blood cell specific NX" "RNA blood lineage specificity" "RNA blood lineage distribution" "RNA blood lineage specificity score" "RNA blood lineage specific NX" "RNA mouse brain regional specificity" "RNA mouse brain regional distribution" "RNA mouse brain regional specificity score" "RNA mouse brain regional specific pTPM" "RNA pig brain regional specificity" "RNA pig brain regional distribution" "RNA pig brain regional specificity score" "RNA pig brain regional specific pTPM" Antibody "Reliability (IH)" "Reliability (Mouse Brain)" "Reliability (IF)" "Subcellular location" "Secretome location" "Blood concentration - Conc. blood IM [pg/L]" "Blood concentration - Conc. blood MS [pg/L]" "Subcellular main location" "Subcellular additional location" "Antibody RRID" "Pathology prognostics - Breast cancer" "Pathology prognostics - Cervical cancer" "Pathology prognostics - Colorectal cancer" "Pathology prognostics - Endometrial cancer" "Pathology prognostics - Glioma" "Pathology prognostics - Head and neck cancer" "Pathology prognostics - Liver cancer" "Pathology prognostics - Lung cancer" "Pathology prognostics - Melanoma" "Pathology prognostics - Ovarian cancer" "Pathology prognostics - Pancreatic cancer" "Pathology prognostics - Prostate cancer" "Pathology prognostics - Renal cancer" "Pathology prognostics - Stomach cancer" "Pathology prognostics - Testis cancer" "Pathology prognostics - Thyroid cancer" "Pathology prognostics - Urothelial cancer" "Tissue RNA - adipose tissue [NX]" "Tissue RNA - adrenal gland [NX]" "Tissue RNA - amygdala [NX]" "Tissue RNA - appendix [NX]" "Tissue RNA - basal ganglia [NX]" "Tissue RNA - bone marrow [NX]" "Tissue RNA - breast [NX]" "Tissue RNA - cerebellum [NX]" "Tissue RNA - cerebral cortex [NX]" "Tissue RNA - cervix, uterine [NX]" "Tissue RNA - colon [NX]" "Tissue RNA - corpus callosum [NX]" "Tissue RNA - ductus deferens [NX]" "Tissue RNA - duodenum [NX]" "Tissue RNA - endometrium 1 [NX]" "Tissue RNA - epididymis [NX]" "Tissue RNA - esophagus [NX]" "Tissue RNA - fallopian tube [NX]" "Tissue RNA - gallbladder [NX]" "Tissue RNA - heart muscle [NX]" "Tissue RNA - hippocampal formation [NX]" "Tissue RNA - hypothalamus [NX]" "Tissue RNA - kidney [NX]" "Tissue RNA - liver [NX]" "Tissue RNA - lung [NX]" "Tissue RNA - lymph node [NX]" "Tissue RNA - midbrain [NX]" "Tissue RNA - olfactory region [NX]" "Tissue RNA - ovary [NX]" "Tissue RNA - pancreas [NX]" "Tissue RNA - parathyroid gland [NX]" "Tissue RNA - pituitary gland [NX]" "Tissue RNA - placenta [NX]" "Tissue RNA - pons and medulla [NX]" "Tissue RNA - prostate [NX]" "Tissue RNA - rectum [NX]" "Tissue RNA - retina [NX]" "Tissue RNA - salivary gland [NX]" "Tissue RNA - seminal vesicle [NX]" "Tissue RNA - skeletal muscle [NX]" "Tissue RNA - skin 1 [NX]" "Tissue RNA - small intestine [NX]" "Tissue RNA - smooth muscle [NX]" "Tissue RNA - spinal cord [NX]" "Tissue RNA - spleen [NX]" "Tissue RNA - stomach 1 [NX]" "Tissue RNA - testis [NX]" "Tissue RNA - thalamus [NX]" "Tissue RNA - thymus [NX]" "Tissue RNA - thyroid gland [NX]" "Tissue RNA - tongue [NX]" "Tissue RNA - tonsil [NX]" "Tissue RNA - urinary bladder [NX]" "Tissue RNA - vagina [NX]" "Tissue RNA - B-cells [NX]" "Tissue RNA - dendritic cells [NX]" "Tissue RNA - granulocytes [NX]" "Tissue RNA - monocytes [NX]" "Tissue RNA - NK-cells [NX]" "Tissue RNA - T-cells [NX]" "Tissue RNA - total PBMC [NX]" "Cell RNA - A-431 [NX]" "Cell RNA - A549 [NX]" "Cell RNA - AF22 [NX]" "Cell RNA - AN3-CA [NX]" "Cell RNA - ASC diff [NX]" "Cell RNA - ASC TERT1 [NX]" "Cell RNA - BEWO [NX]" "Cell RNA - BJ [NX]" "Cell RNA - BJ hTERT+ [NX]" "Cell RNA - BJ hTERT+ SV40 Large T+ [NX]" "Cell RNA - BJ hTERT+ SV40 Large T+ RasG12V [NX]" "Cell RNA - CACO-2 [NX]" "Cell RNA - CAPAN-2 [NX]" "Cell RNA - Daudi [NX]" "Cell RNA - EFO-21 [NX]" "Cell RNA - fHDF/TERT166 [NX]" "Cell RNA - HaCaT [NX]" "Cell RNA - HAP1 [NX]" "Cell RNA - HBEC3-KT [NX]" "Cell RNA - HBF TERT88 [NX]" "Cell RNA - HDLM-2 [NX]" "Cell RNA - HEK 293 [NX]" "Cell RNA - HEL [NX]" "Cell RNA - HeLa [NX]" "Cell RNA - Hep G2 [NX]" "Cell RNA - HHSteC [NX]" "Cell RNA - HL-60 [NX]" "Cell RNA - HMC-1 [NX]" "Cell RNA - HSkMC [NX]" "Cell RNA - hTCEpi [NX]" "Cell RNA - hTEC/SVTERT24-B [NX]" "Cell RNA - hTERT-HME1 [NX]" "Cell RNA - HUVEC TERT2 [NX]" "Cell RNA - K-562 [NX]" "Cell RNA - Karpas-707 [NX]" "Cell RNA - LHCN-M2 [NX]" "Cell RNA - MCF7 [NX]" "Cell RNA - MOLT-4 [NX]" "Cell RNA - NB-4 [NX]" "Cell RNA - NTERA-2 [NX]" "Cell RNA - PC-3 [NX]" "Cell RNA - REH [NX]" "Cell RNA - RH-30 [NX]" "Cell RNA - RPMI-8226 [NX]" "Cell RNA - RPTEC TERT1 [NX]" "Cell RNA - RT4 [NX]" "Cell RNA - SCLC-21H [NX]" "Cell RNA - SH-SY5Y [NX]" "Cell RNA - SiHa [NX]" "Cell RNA - SK-BR-3 [NX]" "Cell RNA - SK-MEL-30 [NX]" "Cell RNA - T-47d [NX]" "Cell RNA - THP-1 [NX]" "Cell RNA - TIME [NX]" "Cell RNA - U-138 MG [NX]" "Cell RNA - U-2 OS [NX]" "Cell RNA - U-2197 [NX]" "Cell RNA - U-251 MG [NX]" "Cell RNA - U-266/70 [NX]" "Cell RNA - U-266/84 [NX]" "Cell RNA - U-698 [NX]" "Cell RNA - U-87 MG [NX]" "Cell RNA - U-937 [NX]" "Cell RNA - WM-115 [NX]" "Blood RNA - basophil [NX]" "Blood RNA - classical monocyte [NX]" "Blood RNA - eosinophil [NX]" "Blood RNA - gdT-cell [NX]" "Blood RNA - intermediate monocyte [NX]" "Blood RNA - MAIT T-cell [NX]" "Blood RNA - memory B-cell [NX]" "Blood RNA - memory CD4 T-cell [NX]" "Blood RNA - memory CD8 T-cell [NX]" "Blood RNA - myeloid DC [NX]" "Blood RNA - naive B-cell [NX]" "Blood RNA - naive CD4 T-cell [NX]" "Blood RNA - naive CD8 T-cell [NX]" "Blood RNA - neutrophil [NX]" "Blood RNA - NK-cell [NX]" "Blood RNA - non-classical monocyte [NX]" "Blood RNA - plasmacytoid DC [NX]" "Blood RNA - T-reg [NX]" "Blood RNA - total PBMC [NX]" "Brain RNA - amygdala [NX]" "Brain RNA - basal ganglia [NX]" "Brain RNA - cerebellum [NX]" "Brain RNA - cerebral cortex [NX]" "Brain RNA - hippocampal formation [NX]" "Brain RNA - hypothalamus [NX]" "Brain RNA - midbrain [NX]" "Brain RNA - olfactory region [NX]" "Brain RNA - pons and medulla [NX]" "Brain RNA - thalamus [NX]" ABHD4 FLJ12816 ENSG00000100439 "Abhydrolase domain containing 4" Q8TB40 14 22598237-22613215 "Enzymes, Predicted intracellular proteins" "Lipid degradation, Lipid metabolism" Hydrolase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell line enhanced" "Detected in many" "ASC diff: 44.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA000600 Uncertain Approved Nucleoplasm Nucleoplasm "HPA000600: AB_1078081" "unprognostic (5.04e-2)" "unprognostic (5.15e-2)" "unprognostic (2.68e-3)" "unprognostic (8.17e-2)" "unprognostic (1.17e-1)" "unprognostic (5.24e-2)" "unprognostic (1.19e-3)" "unprognostic (3.69e-2)" "unprognostic (1.28e-1)" "unprognostic (5.72e-2)" "unprognostic (1.32e-3)" "unprognostic (3.73e-1)" "unprognostic (1.56e-2)" "unprognostic (5.18e-2)" "unprognostic (1.37e-1)" "unprognostic (4.51e-2)" "unprognostic (1.03e-2)" 17.2 24.9 12.8 6.4 14.5 10.0 20.5 12.3 13.9 19.4 14.7 21.4 37.5 13.4 26.0 26.2 28.6 14.4 22.4 16.4 14.1 10.4 23.9 17.0 13.6 8.7 18.9 12.9 15.4 11.4 14.8 12.2 15.9 15.5 19.3 12.8 22.2 13.9 35.5 17.9 14.2 26.3 22.8 18.5 11.9 18.5 45.0 16.4 5.1 25.1 11.1 14.7 23.2 20.7 3.8 2.8 18.6 4.2 4.4 6.0 3.4 8.0 13.5 5.5 5.0 44.8 16.3 5.3 3.6 18.5 9.1 17.0 8.1 12.9 0.7 9.6 15.8 15.7 3.5 9.4 7.5 5.9 1.2 3.0 9.4 26.8 20.5 0.4 10.9 20.6 7.4 11.9 10.2 9.3 2.2 14.7 8.3 4.4 0.2 0.4 6.7 9.8 2.2 4.9 3.3 10.6 8.6 0.3 1.1 24.3 8.7 9.3 3.4 0.9 6.6 4.0 5.5 6.4 1.4 15.9 8.2 0.2 3.0 0.6 3.1 18.6 4.2 6.6 6.0 3.2 5.0 3.8 3.9 3.9 2.8 2.4 1.3 2.6 17.4 4.4 2.9 0.4 2.3 3.4 12.8 14.5 12.3 13.0 14.1 10.4 18.9 12.9 15.5 16.4 ABHD5 "CGI-58, NCIE2" ENSG00000011198 "Abhydrolase domain containing 5" Q8WTS1 3 43690108-43734371 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" "Differentiation, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism" "Acyltransferase, Transferase" "Cataract, Deafness, Disease mutation, Ichthyosis" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "breast: 70.3" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 4 "basophil: 26.1;classical monocyte: 7.6;neutrophil: 21.0" "Group enriched" "Detected in many" 5 "granulocytes: 26.1;monocytes: 7.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB020685, HPA035851, HPA035852" Approved Approved Vesicles Vesicles "CAB020685: , HPA035851: AB_10671942, HPA035852: AB_10672073" "unprognostic (2.58e-1)" "unprognostic (2.73e-1)" "prognostic favourable (8.89e-4)" "unprognostic (1.07e-1)" "unprognostic (1.75e-2)" "unprognostic (2.26e-1)" "unprognostic (6.13e-2)" "unprognostic (2.40e-2)" "unprognostic (5.33e-2)" "unprognostic (3.50e-3)" "unprognostic (2.56e-2)" "unprognostic (4.13e-3)" "prognostic favourable (9.17e-5)" "unprognostic (2.48e-1)" "unprognostic (8.87e-2)" "unprognostic (4.18e-2)" "unprognostic (4.18e-2)" 26.5 10.5 5.2 7.4 12.2 32.2 70.3 8.5 10.3 7.6 10.2 10.5 5.9 7.4 4.6 4.0 22.7 3.7 10.4 9.8 7.4 4.5 10.1 18.4 14.1 8.7 18.5 4.6 4.2 12.8 9.1 8.6 20.2 14.9 5.8 6.7 4.4 21.1 7.4 10.4 24.8 15.1 8.1 19.0 7.0 8.9 8.1 12.5 3.3 13.2 9.9 6.7 11.2 16.0 1.7 3.6 26.1 7.6 0.9 2.4 2.5 8.3 2.9 3.5 3.7 14.9 5.7 7.3 34.2 13.6 9.4 7.1 4.6 2.9 7.0 4.7 10.7 2.8 5.5 8.3 9.6 25.3 5.4 17.8 11.4 3.1 7.4 4.0 5.8 6.3 28.9 15.8 13.5 15.7 10.6 5.3 20.9 4.5 2.9 2.8 9.5 9.6 1.2 10.2 4.0 12.2 16.7 4.4 5.9 15.0 8.1 3.5 8.7 3.5 8.7 8.3 6.6 15.4 14.8 4.8 13.3 3.3 8.9 7.4 6.4 26.1 7.6 4.4 1.2 3.7 1.0 1.7 0.9 1.4 3.6 1.2 0.8 1.3 21.0 0.9 2.7 0.9 2.4 2.5 5.2 12.2 8.5 10.3 7.4 4.5 18.5 4.6 14.9 12.5 ACE "ACE1, CD143, DCP1" ENSG00000159640 "Angiotensin I converting enzyme" P12821 17 63477061-63498380 "Candidate cardiovascular disease genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 5 "intestine: 205.6" "Group enriched" "Detected in some" 4 "ASC TERT1: 35.9;HUVEC TERT2: 18.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in some" "Cell type enhanced" "Detected in some" "memory B-cell: 3.7" "Group enriched" "Detected in many" 23 "B-cells: 3.7;monocytes: 2.0;T-cells: 1.9" "CAB002426, CAB002921, HPA029298, HPA069790" Enhanced Approved Vesicles "Secreted to blood" 121920000 92000000 Vesicles "CAB002426: AB_442052, CAB002921: , HPA029298: AB_10960255, HPA069790: " "unprognostic (4.72e-2)" "unprognostic (4.16e-1)" "unprognostic (1.93e-3)" "unprognostic (6.06e-2)" "unprognostic (2.78e-1)" "unprognostic (1.35e-2)" "unprognostic (4.37e-1)" "unprognostic (1.54e-1)" "unprognostic (1.56e-1)" "unprognostic (1.25e-2)" "unprognostic (3.13e-2)" "unprognostic (2.38e-1)" "unprognostic (7.66e-2)" "unprognostic (9.07e-2)" "unprognostic (1.66e-1)" "unprognostic (1.08e-1)" "unprognostic (2.76e-2)" 6.8 2.0 0.5 2.4 4.2 0.0 2.9 0.5 1.1 5.3 83.2 0.7 37.7 46.4 4.5 5.1 1.7 1.5 4.4 4.7 0.6 0.7 2.6 1.4 16.3 2.2 0.4 0.7 1.4 3.0 3.6 3.6 3.6 0.8 3.4 1.4 1.7 2.5 20.1 3.6 1.3 205.6 2.4 0.6 1.4 1.9 32.6 1.3 0.5 6.9 3.1 2.2 1.7 1.6 3.7 0.1 0.0 2.0 0.0 1.9 0.4 0.0 0.0 0.0 0.0 1.5 35.9 0.4 1.3 2.6 0.0 0.0 0.5 3.1 0.7 1.0 6.1 0.0 1.7 0.0 0.0 0.0 0.7 3.4 0.0 0.0 0.8 0.0 0.0 2.4 0.0 0.0 0.0 18.3 3.0 0.0 0.0 0.6 0.0 0.7 0.2 0.3 0.1 0.2 0.5 0.0 0.0 4.5 3.2 0.0 0.0 0.0 1.6 0.2 0.0 0.1 0.1 0.3 0.0 0.0 0.0 0.0 0.5 0.0 0.2 0.0 0.0 0.0 0.4 0.6 0.9 3.7 1.9 1.4 0.1 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.4 0.5 4.2 0.5 1.1 0.6 0.7 0.4 0.7 0.8 1.3 ACE2 ENSG00000130234 "Angiotensin I converting enzyme 2" Q9BYF1 X 15561033-15602148 "Enzymes, FDA approved drug targets, Predicted membrane proteins, Predicted secreted proteins" "Host-virus interaction" "Carboxypeptidase, Host cell receptor for virus entry, Hydrolase, Metalloprotease, Protease, Receptor" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 5 "intestine: 122.0" "Cell line enhanced" "Detected in some" "BEWO: 2.4;HaCaT: 4.1;Hep G2: 2.4;NB-4: 2.2;RPMI-8226: 2.0;RT4: 2.4;SH-SY5Y: 2.8" "Cancer enhanced" "Detected in many" "renal cancer: 26.9" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in all" "Not detected" "Not detected" "HPA000288, CAB026174" Enhanced "Secreted to blood" 85000 "CAB026174: , HPA000288: AB_1078160" "unprognostic (1.40e-1)" "unprognostic (7.26e-2)" "unprognostic (2.76e-2)" "unprognostic (5.71e-2)" "unprognostic (2.51e-1)" "unprognostic (5.26e-2)" "prognostic favourable (4.21e-4)" "unprognostic (2.34e-2)" "unprognostic (6.74e-3)" "unprognostic (2.54e-3)" "unprognostic (1.00e-1)" "unprognostic (1.74e-1)" "prognostic favourable (2.12e-5)" "unprognostic (1.94e-1)" "unprognostic (9.62e-2)" "unprognostic (2.11e-1)" "unprognostic (7.10e-2)" 4.5 0.4 0.2 0.8 0.2 0.0 2.3 0.2 0.2 0.4 49.1 0.2 2.3 46.0 0.4 2.7 1.2 0.6 16.4 10.5 0.2 0.1 23.2 1.2 0.8 0.6 0.2 0.2 1.3 1.6 0.0 0.2 1.0 0.2 0.5 1.3 0.2 1.1 1.2 0.7 0.2 122.0 0.3 0.2 0.2 0.5 17.9 0.2 0.2 4.5 0.5 0.2 0.4 0.9 0.0 0.0 0.2 0.0 0.0 0.3 0.0 0.2 0.0 0.4 0.0 0.7 0.0 2.4 0.0 0.0 0.0 0.0 0.0 1.3 0.0 0.6 0.0 4.1 0.2 0.1 0.0 0.1 0.1 0.0 0.0 2.4 0.0 0.0 0.0 0.0 0.3 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 2.2 0.1 0.2 0.0 0.0 2.0 0.4 2.4 0.6 2.8 0.1 0.3 0.2 0.2 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.2 0.2 0.2 0.2 0.2 0.1 0.2 0.2 0.2 0.2 ACR ENSG00000100312 Acrosin P10323 22 50738196-50745334 "Enzymes, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 87 "testis: 106.3" "Cell line enhanced" "Detected in some" "Hep G2: 1.7;HUVEC TERT2: 1.1;NTERA-2: 1.7;TIME: 1.4" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in many" "Low region specificity" "Detected in single" HPA048687 Enhanced "Secreted in male reproductive system" "HPA048687: " "unprognostic (1.71e-1)" "unprognostic (1.26e-1)" "unprognostic (1.04e-1)" "unprognostic (6.27e-3)" "unprognostic (3.58e-2)" "unprognostic (8.04e-2)" "unprognostic (3.30e-3)" "unprognostic (5.41e-2)" "unprognostic (1.51e-1)" "unprognostic (2.28e-1)" "unprognostic (1.34e-2)" "unprognostic (2.12e-1)" "unprognostic (1.48e-1)" "unprognostic (1.23e-2)" "unprognostic (1.71e-1)" "unprognostic (2.27e-1)" "unprognostic (1.25e-1)" 0.9 0.0 0.2 0.2 0.3 0.0 0.6 0.2 0.3 0.2 0.2 0.2 0.2 0.1 0.3 0.7 0.2 0.4 0.2 0.2 0.2 0.0 0.2 0.3 0.6 0.2 0.2 0.2 0.2 0.2 0.0 0.2 0.2 0.2 0.2 0.0 0.2 0.4 0.2 0.2 0.2 0.2 0.2 0.2 1.2 0.0 106.3 0.2 0.2 0.2 0.3 0.2 0.2 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.5 0.0 0.6 0.2 0.0 0.0 0.0 0.3 0.0 0.9 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 1.7 0.0 0.0 0.1 0.0 0.3 0.0 0.0 1.1 0.0 0.0 0.0 0.4 0.0 0.0 1.7 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.2 0.1 0.0 0.1 0.0 0.0 1.4 0.0 0.7 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.3 0.2 0.3 0.2 0.0 0.2 0.2 0.2 0.2 ACY1 ENSG00000243989 "Aminoacylase 1" Q03154 3 51983278-51989202 "Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins" Hydrolase "Disease mutation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in all" 6 "intestine: 53.3;kidney: 91.6;liver: 77.8" "Low cell line specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in all" "CAB003695, HPA036174, HPA036175" Enhanced 28000000 "CAB003695: AB_425286, HPA036174: , HPA036175: " "unprognostic (4.28e-2)" "unprognostic (1.89e-1)" "unprognostic (2.10e-1)" "unprognostic (2.48e-3)" "unprognostic (3.15e-1)" "unprognostic (6.51e-2)" "unprognostic (2.82e-2)" "unprognostic (1.47e-1)" "unprognostic (1.05e-2)" "unprognostic (6.08e-2)" "unprognostic (2.36e-2)" "unprognostic (2.70e-2)" "prognostic favourable (2.93e-4)" "unprognostic (3.57e-1)" "unprognostic (3.75e-1)" "unprognostic (7.88e-2)" "prognostic favourable (6.77e-4)" 4.4 8.5 2.5 3.9 3.0 1.5 4.4 1.5 3.3 3.2 24.9 4.1 9.8 34.5 1.9 7.9 3.8 3.0 8.4 4.1 2.3 1.8 91.6 77.8 3.5 6.3 2.8 2.9 2.1 9.0 6.2 1.9 4.3 2.9 3.7 6.2 6.6 9.4 9.2 7.6 2.6 53.3 2.1 3.5 3.4 4.9 1.5 1.7 0.6 5.9 6.7 4.1 3.3 2.5 5.0 12.1 3.8 10.0 12.1 6.4 4.5 3.9 8.0 3.9 10.9 9.0 12.2 12.9 4.2 7.9 9.3 5.1 12.5 20.9 2.5 3.6 7.3 4.9 4.0 25.7 3.7 7.0 5.1 9.0 4.6 38.5 16.7 6.0 5.8 14.0 21.3 8.2 22.2 3.5 13.5 8.0 9.1 11.2 0.0 11.0 5.7 13.6 3.1 3.3 22.6 24.4 15.1 5.5 5.0 5.3 17.6 9.3 14.2 7.9 1.7 6.7 6.4 8.3 5.0 21.0 4.9 3.8 7.9 12.6 8.1 3.8 10.0 0.2 6.4 9.0 3.6 5.0 2.0 2.8 12.1 4.0 3.3 4.0 0.0 12.1 3.4 1.9 2.7 4.5 2.5 3.0 1.5 3.3 2.3 1.8 2.8 2.9 2.9 1.7 ADGB "C6orf103, CAPN16, dJ408K24.1, FLJ23121" ENSG00000118492 Androglobin Q8N7X0 6 146598965-146815462 "Enzymes, Predicted intracellular proteins" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "brain: 20.9;epididymis: 13.1;testis: 30.6" "Cell line enriched" "Detected in single" 25 "HDLM-2: 17.5" "Not detected" "Not detected" "Group enriched" "Detected in many" 5 "basal ganglia: 6.6;pons and medulla: 20.9" "Cell type enriched" "Detected in single" 10 "myeloid DC: 2.6" "Lineage enriched" "Detected in single" 10 "dendritic cells: 2.6" "Low region specificity" "Detected in all" "HPA036340, HPA036341" Enhanced Uncertain Nucleoplasm,Mitochondria Mitochondria Nucleoplasm "HPA036340: , HPA036341: AB_10672241" "unprognostic (4.15e-3)" "unprognostic (1.23e-2)" "unprognostic (9.30e-3)" "unprognostic (1.09e-1)" "unprognostic (2.07e-2)" "unprognostic (3.11e-2)" "unprognostic (5.05e-1)" "unprognostic (2.34e-1)" "unprognostic (4.83e-3)" "unprognostic (1.05e-1)" "unprognostic (1.93e-1)" "unprognostic (1.77e-2)" "unprognostic (3.66e-2)" "unprognostic (2.68e-1)" 0.1 0.1 1.6 0.1 6.6 0.1 0.2 0.0 0.2 1.0 0.5 5.1 0.0 0.1 0.4 13.1 0.2 9.8 0.1 0.1 2.2 2.7 0.2 0.2 4.8 0.2 0.0 0.0 4.3 0.1 0.3 0.8 0.2 20.9 0.2 0.4 0.0 0.1 0.3 0.1 0.3 0.1 0.1 0.4 0.1 0.2 30.6 1.2 0.0 0.2 0.1 0.2 0.1 0.0 0.0 2.6 0.0 0.2 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 17.5 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 1.6 6.6 0.0 0.1 2.2 2.7 0.0 0.0 20.9 1.2 AEBP1 ACLP ENSG00000106624 "AE binding protein 1" Q8IUX7 7 44104361-44114562 "Enzymes, Predicted intracellular proteins, Predicted secreted proteins" "Transcription, Transcription regulation" "Calmodulin-binding, DNA-binding, Repressor" "Disease mutation, Ehlers-Danlos syndrome" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "vagina: 177.1" "Cell line enhanced" "Detected in many" "ASC diff: 35.0;BJ: 46.1;BJ hTERT+: 30.4;fHDF/TERT166: 49.4;WM-115: 28.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Cell type enriched" "Detected in some" 5 "plasmacytoid DC: 10.5" "Lineage enriched" "Detected in many" 5 "dendritic cells: 10.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" "CAB009966, HPA047724, HPA063595, HPA064970" Supported Supported Nucleoplasm,Vesicles,Cytosol "Secreted - unknown location" 2300000 Vesicles "Nucleoplasm, Cytosol" "CAB009966: AB_2225690, HPA047724: , HPA063595: , HPA064970: " "unprognostic (1.70e-2)" "unprognostic (5.42e-2)" "unprognostic (1.66e-2)" "unprognostic (1.45e-1)" "prognostic unfavourable (1.60e-4)" "unprognostic (1.13e-1)" "unprognostic (7.00e-2)" "unprognostic (8.79e-2)" "unprognostic (2.52e-1)" "unprognostic (3.27e-2)" "unprognostic (1.26e-1)" "unprognostic (1.94e-1)" "prognostic unfavourable (9.31e-9)" "unprognostic (2.88e-3)" "unprognostic (9.58e-2)" "unprognostic (1.17e-2)" "unprognostic (6.28e-3)" 46.5 19.0 8.9 23.9 9.5 3.1 90.9 1.7 5.4 78.1 20.5 17.9 15.8 5.8 73.7 39.4 20.7 43.7 47.9 35.4 12.7 6.4 19.6 6.3 35.5 13.0 12.5 10.8 84.8 8.8 2.7 10.9 26.7 17.2 46.1 7.9 33.3 11.9 70.2 11.4 19.7 16.9 42.6 43.7 16.6 17.6 30.6 9.6 48.0 19.6 12.3 7.5 58.2 177.1 2.3 10.5 0.0 0.0 0.2 1.4 0.4 0.1 0.0 10.8 0.0 35.0 12.4 0.2 46.1 30.4 5.2 1.1 0.0 0.0 1.2 5.1 49.4 0.0 0.5 0.8 2.2 0.1 0.0 3.1 0.0 0.0 9.8 0.0 0.0 18.8 0.0 17.7 0.0 2.3 1.9 0.0 0.0 0.0 19.9 3.7 4.6 0.0 16.6 0.4 0.3 1.2 0.0 1.1 6.1 0.0 0.0 20.2 0.1 3.3 8.1 0.0 21.4 0.1 0.0 0.2 0.2 24.3 0.1 0.0 28.3 0.0 0.0 0.0 0.4 0.0 0.3 2.1 0.4 0.0 0.0 2.3 1.4 0.8 0.0 0.2 0.0 10.5 0.0 0.4 8.9 9.5 1.7 5.4 12.7 6.4 12.5 10.8 17.2 9.6 AFG3L2 "SCA28, SPAX5" ENSG00000141385 "AFG3 like matrix AAA peptidase subunit 2" Q9Y4W6 18 12328944-12377314 "Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted membrane proteins" "Hydrolase, Metalloprotease, Protease" "Disease mutation, Neurodegeneration, Spinocerebellar ataxia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA004479, HPA004480" Enhanced Supported Mitochondria Mitochondria "HPA004479: AB_1078109, HPA004480: AB_1078108" "unprognostic (1.11e-1)" "unprognostic (7.49e-2)" "unprognostic (1.67e-1)" "prognostic unfavourable (8.68e-4)" "unprognostic (1.31e-1)" "unprognostic (5.06e-3)" "unprognostic (1.61e-1)" "unprognostic (2.33e-1)" "unprognostic (5.35e-2)" "unprognostic (1.54e-2)" "unprognostic (4.05e-2)" "unprognostic (3.00e-2)" "prognostic favourable (6.05e-14)" "unprognostic (5.90e-2)" "unprognostic (9.41e-2)" "unprognostic (5.74e-3)" "unprognostic (2.22e-1)" 11.5 15.8 11.8 14.3 14.0 11.7 19.9 17.2 30.3 11.2 25.7 9.5 12.7 33.1 11.4 10.1 18.3 10.4 11.2 77.4 13.2 13.1 27.2 22.9 16.3 23.7 12.0 13.2 12.0 23.1 34.3 12.6 9.9 16.9 10.8 23.5 12.2 14.9 14.8 61.0 17.5 35.0 15.1 14.0 9.9 16.0 8.9 7.1 10.7 16.9 22.4 13.2 14.0 11.6 10.1 15.8 8.5 12.3 19.9 15.2 8.4 16.9 17.4 12.4 14.0 14.4 15.7 16.6 19.0 19.0 27.3 20.0 26.9 10.5 48.9 21.0 17.3 17.1 31.4 21.9 22.3 11.4 13.4 14.6 19.0 25.1 19.7 55.1 22.0 17.4 24.0 25.8 34.2 19.8 32.9 29.0 13.3 26.9 19.7 16.9 17.3 12.8 22.2 39.3 40.8 23.4 37.8 23.2 16.2 29.9 32.4 26.7 14.9 25.0 15.0 32.5 28.0 30.9 24.8 20.4 23.5 31.4 17.8 21.7 14.9 2.6 11.5 8.5 8.7 12.3 10.7 10.1 10.4 13.7 15.8 7.7 13.3 15.2 0.8 19.9 10.8 8.1 6.4 8.4 11.8 14.0 17.2 30.3 13.2 13.1 12.0 13.2 16.9 7.1 AGBL1 "CCP4, FLJ32310" ENSG00000273540 "ATP/GTP binding protein like 1" Q96MI9 15 86079973-87029052 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Corneal dystrophy" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 4 "skeletal muscle: 16.7;tongue: 35.5" "Cell line enhanced" "Detected in some" "AF22: 2.5;RH-30: 1.8;SCLC-21H: 2.8" "Not detected" "Not detected" "Cell type enhanced" "Detected in single" "neutrophil: 1.3" "Low lineage specificity" "Detected in single" "Low region specificity" "Detected in single" "unprognostic (3.70e-2)" "unprognostic (4.46e-2)" "unprognostic (1.06e-1)" 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.8 0.0 0.0 0.4 0.0 0.0 0.0 5.8 1.3 0.0 0.0 0.0 0.1 0.0 0.0 2.9 0.0 0.0 0.1 0.0 0.0 0.0 0.2 0.0 0.6 0.6 0.0 0.0 1.3 0.0 16.7 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.5 35.5 1.0 0.0 0.0 0.5 0.3 1.3 0.3 0.3 0.2 0.0 0.0 0.1 2.5 0.2 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.7 0.3 0.0 0.1 0.1 0.1 0.0 0.0 0.1 0.0 0.1 0.2 0.0 0.1 0.1 0.2 0.0 0.1 0.1 1.8 0.1 0.0 0.2 2.8 0.2 0.3 0.0 0.0 0.1 0.0 0.0 0.2 0.4 0.2 0.0 0.2 0.0 0.2 0.1 0.1 0.0 0.7 0.3 0.2 0.1 0.1 0.1 0.2 0.2 0.2 0.0 0.5 0.1 0.1 1.3 0.3 0.0 0.3 0.1 0.0 AGBL2 "CCP2, FLJ23598" ENSG00000165923 "ATP/GTP binding protein like 2" Q5U5Z8 11 47659591-47715389 "Enzymes, Predicted intracellular proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "testis: 34.0" "Cell line enhanced" "Detected in some" "CAPAN-2: 6.0;T-47d: 3.5" "Low cancer specificity" "Detected in some" "Low region specificity" "Detected in many" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA007718 Uncertain "HPA007718: AB_1078110" "unprognostic (3.44e-5)" "unprognostic (1.16e-1)" "unprognostic (5.84e-2)" "unprognostic (5.33e-4)" "unprognostic (1.13e-1)" "unprognostic (3.00e-1)" "unprognostic (2.05e-1)" "unprognostic (1.38e-2)" "unprognostic (9.83e-3)" "unprognostic (4.11e-2)" "unprognostic (5.56e-2)" "unprognostic (1.79e-1)" "unprognostic (8.24e-6)" "unprognostic (1.01e-2)" "unprognostic (1.28e-1)" "unprognostic (9.62e-2)" "unprognostic (1.17e-3)" 0.4 1.7 0.8 6.6 2.7 0.7 1.1 3.6 1.1 1.9 2.0 2.8 1.5 1.1 1.6 11.2 0.5 12.2 2.4 0.4 1.3 1.4 1.8 3.0 6.4 1.4 0.3 0.3 2.1 4.7 1.2 3.8 0.7 3.4 1.6 0.8 0.7 1.1 1.7 0.4 0.6 3.3 0.6 0.7 1.7 0.8 34.0 0.7 4.4 1.9 0.5 2.6 2.1 1.4 2.6 1.5 0.4 0.2 1.4 2.2 0.6 1.2 0.0 0.0 0.0 0.3 1.7 0.1 0.4 0.8 0.5 1.7 0.6 6.0 0.1 0.4 0.4 1.6 0.0 0.1 0.8 1.8 0.4 0.3 2.9 2.2 0.9 0.0 1.0 1.8 0.7 0.9 0.5 0.1 0.4 1.3 0.9 2.3 1.2 0.6 0.0 0.1 1.7 0.1 0.5 0.9 2.7 2.2 0.5 0.7 0.0 0.7 3.5 0.0 0.2 0.2 0.4 0.3 0.0 0.0 0.1 0.1 0.3 0.3 0.3 0.0 0.1 0.0 1.5 0.0 1.3 1.0 1.6 1.2 0.1 2.6 1.9 1.7 0.4 1.4 0.2 1.5 2.2 0.6 0.8 2.7 3.6 1.1 1.3 1.4 0.3 0.3 3.4 0.7 AGBL3 "CCP3, MGC32955" ENSG00000146856 "ATP/GTP binding protein like 3" Q8NEM8 7 134986508-135147963 "Enzymes, Predicted intracellular proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Low tissue specificity" "Detected in many" "Cell line enhanced" "Detected in many" "HEK 293: 8.8" "Low cancer specificity" "Detected in some" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA020397, HPA024150" Uncertain Uncertain "Nuclear speckles,Mitochondria,Cytosol" "Nuclear speckles, Mitochondria, Cytosol" "HPA020397: AB_2242453, HPA024150: AB_1844639" "unprognostic (8.84e-2)" "unprognostic (1.49e-2)" "unprognostic (4.72e-2)" "unprognostic (2.18e-1)" "unprognostic (1.47e-1)" "unprognostic (3.39e-3)" "unprognostic (3.32e-3)" "unprognostic (4.18e-2)" "unprognostic (7.15e-4)" "unprognostic (5.00e-3)" "unprognostic (6.10e-4)" "unprognostic (3.16e-2)" "prognostic unfavourable (4.02e-4)" "unprognostic (2.18e-2)" "unprognostic (2.14e-1)" "unprognostic (8.13e-2)" "unprognostic (1.11e-3)" 3.2 2.7 4.2 4.1 8.4 3.8 4.6 8.7 4.5 4.3 2.4 4.4 4.5 1.6 5.5 15.4 2.2 3.6 3.1 2.4 5.0 3.4 5.3 2.6 3.6 4.0 2.7 4.5 6.8 4.5 0.6 9.2 1.9 3.3 3.8 3.0 3.1 4.9 4.3 4.2 4.7 3.7 3.3 2.9 6.5 4.4 18.7 3.7 2.7 5.4 0.8 2.8 3.3 2.5 2.2 1.7 0.5 0.2 2.2 5.0 1.7 2.6 1.4 3.6 0.8 1.0 1.4 2.2 0.7 0.0 0.5 0.8 4.7 3.0 4.3 1.3 0.0 2.8 1.3 0.5 0.0 3.4 8.8 3.6 5.3 4.6 0.0 1.6 0.0 0.2 0.0 2.1 0.0 1.5 2.6 2.5 0.6 2.5 0.9 1.5 3.1 0.3 2.5 0.2 1.2 2.6 0.5 2.1 2.4 0.5 0.0 0.3 1.9 3.5 0.0 0.4 0.9 0.5 1.6 5.3 1.6 1.9 1.8 4.3 4.4 0.0 0.2 0.4 2.4 0.0 1.8 2.1 1.2 2.5 0.5 2.2 2.0 5.0 0.5 2.2 0.1 1.7 1.7 1.7 4.2 8.4 8.7 4.5 5.0 3.4 2.7 4.5 3.3 3.7 AGBL4 "CCP6, FLJ14442" ENSG00000186094 "ATP/GTP binding protein like 4" Q5VU57 1 48532855-50023913 "Enzymes, Predicted intracellular proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Tissue enhanced" "Detected in many" "brain: 20.4;pituitary gland: 31.5" "Cell line enhanced" "Detected in some" "NTERA-2: 3.6;SCLC-21H: 5.2;SH-SY5Y: 2.0;U-937: 2.2" "Not detected" "Not detected" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low region specificity" "Detected in many" HPA037994 Approved "HPA037994: AB_10673036" "unprognostic (3.06e-2)" "unprognostic (2.76e-1)" "unprognostic (2.58e-2)" "unprognostic (3.31e-4)" "unprognostic (3.42e-4)" "unprognostic (1.72e-1)" "unprognostic (3.86e-3)" "unprognostic (2.31e-2)" "unprognostic (1.50e-1)" "unprognostic (1.14e-1)" "unprognostic (5.85e-3)" "unprognostic (3.91e-2)" "unprognostic (1.51e-4)" "unprognostic (5.95e-2)" "unprognostic (1.11e-1)" "unprognostic (1.18e-2)" "unprognostic (2.85e-1)" 1.4 4.5 7.8 0.8 13.6 1.1 1.5 1.3 20.4 1.0 0.8 3.0 0.1 0.7 1.0 4.5 0.9 7.8 1.0 3.7 7.1 7.2 10.2 4.6 1.6 0.8 3.2 11.6 1.3 2.7 3.6 31.5 2.7 6.7 1.0 0.7 4.6 0.8 1.5 0.9 1.5 0.8 0.7 1.5 1.3 1.1 10.7 1.9 0.0 3.4 0.0 0.8 0.7 0.7 0.8 0.5 2.2 0.3 0.6 1.8 0.2 0.0 0.5 0.8 0.2 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.9 0.1 0.2 0.2 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.3 0.2 0.0 0.3 0.1 0.4 3.6 0.4 0.1 0.1 0.1 0.1 0.3 5.2 2.0 0.0 0.2 0.0 0.0 0.3 0.0 0.0 1.4 0.2 0.0 0.2 0.0 0.1 0.1 2.2 0.5 2.2 0.3 0.4 0.3 0.3 1.8 0.5 0.2 0.1 0.2 0.8 0.4 0.2 1.0 0.6 0.2 0.5 0.3 0.2 7.8 13.6 1.3 20.4 7.1 7.2 3.2 11.6 6.7 1.9 AGBL5 "CCP5, FLJ21839" ENSG00000084693 "ATP/GTP binding protein like 5" Q8NDL9 2 27042364-27070622 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Disease mutation, Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in all" 8 "testis: 91.6" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA030981 Uncertain Supported "Microtubules,Cytokinetic bridge,Cytosol" "Cytokinetic bridge" "Microtubules, Cytosol" "HPA030981: AB_10611673" "unprognostic (1.29e-2)" "unprognostic (8.70e-2)" "unprognostic (2.26e-1)" "unprognostic (3.13e-3)" "unprognostic (1.95e-1)" "unprognostic (1.07e-1)" "prognostic unfavourable (6.87e-5)" "unprognostic (1.86e-1)" "unprognostic (4.34e-1)" "unprognostic (6.20e-2)" "unprognostic (1.28e-1)" "unprognostic (1.20e-1)" "unprognostic (3.41e-2)" "unprognostic (5.56e-2)" "unprognostic (2.05e-1)" "unprognostic (1.69e-2)" "unprognostic (4.50e-2)" 3.8 8.1 3.9 3.5 4.8 3.8 4.2 3.1 6.6 5.0 6.8 6.6 11.7 2.8 5.4 9.3 6.3 7.2 6.6 4.1 3.4 3.9 8.2 3.0 3.6 3.2 3.5 3.4 5.9 5.9 11.2 6.2 6.3 5.4 6.8 3.8 7.7 8.2 5.9 2.6 6.8 3.9 8.6 3.4 4.6 5.4 91.6 3.5 8.4 9.9 4.9 4.4 7.8 3.5 5.7 5.4 7.1 2.3 11.2 6.3 4.6 22.8 14.8 24.3 16.2 5.2 10.5 27.2 4.7 10.2 13.6 14.1 12.8 17.5 12.7 14.8 8.1 10.5 19.4 21.2 15.1 10.6 28.8 18.6 18.5 27.6 10.6 8.9 6.3 10.9 16.1 11.9 9.8 14.2 15.9 10.4 13.1 9.0 26.0 13.5 17.2 10.2 26.9 27.5 19.9 13.9 5.8 16.3 23.3 9.2 7.3 15.1 10.9 6.9 6.7 12.7 17.5 6.1 10.0 20.7 10.8 26.0 14.1 10.3 11.3 7.1 2.3 5.7 4.5 1.3 3.4 5.7 5.7 6.3 5.4 3.0 5.1 2.8 1.4 11.2 0.9 3.0 3.6 4.6 3.9 4.8 3.1 6.6 3.4 3.9 3.5 3.4 5.4 3.5 AGTPBP1 "CCP1, KIAA1035, Nna1" ENSG00000135049 "ATP/GTP binding protein 1" Q9UPW5 9 85546539-85742029 "Enzymes, Predicted intracellular proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Disease mutation, Neurodegeneration" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 48.2" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA057208 Approved Approved Nucleoli,Vesicles "Nucleoli, Vesicles" "HPA057208: " "unprognostic (2.15e-1)" "unprognostic (3.78e-2)" "unprognostic (4.93e-3)" "unprognostic (6.12e-2)" "unprognostic (1.42e-1)" "unprognostic (8.95e-3)" "unprognostic (1.86e-2)" "unprognostic (1.65e-1)" "unprognostic (1.71e-1)" "unprognostic (8.26e-3)" "unprognostic (5.69e-3)" "unprognostic (6.31e-2)" "unprognostic (3.07e-2)" "unprognostic (1.11e-1)" "unprognostic (1.39e-1)" "unprognostic (9.60e-3)" "unprognostic (1.25e-1)" 7.9 5.7 13.1 8.6 14.6 48.2 6.0 14.2 21.4 5.1 5.0 21.6 1.8 3.8 5.0 4.2 5.4 4.2 5.3 11.2 17.3 13.5 6.8 4.5 11.9 16.0 18.8 14.5 3.5 6.4 8.0 4.8 6.0 23.5 4.9 5.9 7.4 3.9 3.4 13.6 6.0 4.3 6.4 24.1 12.8 5.3 12.5 14.4 8.8 5.8 4.3 7.8 5.7 3.8 1.6 10.7 20.3 9.5 4.5 6.6 5.7 2.9 5.7 16.8 6.7 3.5 3.8 6.4 4.4 3.8 4.5 5.1 3.0 5.1 18.3 3.7 4.5 1.7 7.8 5.6 4.3 19.4 6.9 3.1 6.9 5.4 7.3 14.1 3.7 3.5 6.6 4.2 14.5 7.2 3.9 14.7 2.0 4.6 10.9 8.4 11.7 4.0 10.0 6.2 5.6 7.8 3.2 20.4 14.5 5.0 5.5 9.1 2.1 4.6 7.1 2.9 5.2 18.5 5.2 10.1 8.4 8.4 6.2 13.9 5.9 20.3 9.5 8.3 6.6 5.7 6.4 1.6 3.3 5.1 10.7 1.2 2.7 5.2 14.0 4.5 4.3 1.7 3.4 5.7 13.1 14.6 14.2 21.4 17.3 13.5 18.8 14.5 23.5 14.4 AMZ1 KIAA1950 ENSG00000174945 "Archaelysin family metallopeptidase 1" Q400G9 7 2679522-2775500 "Enzymes, Predicted intracellular proteins" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 10.0" "Cell line enhanced" "Detected in some" "BEWO: 6.1;MCF7: 6.3;SK-BR-3: 4.5;T-47d: 23.9" "Low cancer specificity" "Detected in some" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 6 "memory B-cell: 4.2;naive B-cell: 2.4;T-reg: 1.0" "Group enriched" "Detected in many" 6 "B-cells: 4.2;T-cells: 1.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" HPA020233 Uncertain "HPA020233: AB_1844818" "unprognostic (9.08e-3)" "unprognostic (1.66e-1)" "unprognostic (3.23e-3)" "unprognostic (1.81e-1)" "unprognostic (5.72e-2)" "unprognostic (7.79e-2)" "unprognostic (2.02e-2)" "unprognostic (3.42e-1)" "unprognostic (1.98e-1)" "unprognostic (7.16e-3)" "unprognostic (1.08e-1)" "unprognostic (1.21e-1)" "unprognostic (3.64e-9)" "unprognostic (1.60e-3)" "unprognostic (1.60e-1)" "unprognostic (1.44e-1)" "unprognostic (1.13e-1)" 0.7 0.7 8.4 1.2 7.1 2.0 0.9 1.4 10.0 3.2 0.6 6.5 0.0 0.8 4.0 0.6 0.7 1.4 1.0 0.9 5.9 4.9 0.5 1.2 2.8 1.2 6.0 4.8 1.4 0.8 0.7 1.1 3.6 4.2 0.8 0.7 0.2 0.6 0.6 0.6 0.8 0.6 3.3 3.8 2.0 0.7 1.4 4.4 0.0 0.7 0.0 1.8 0.7 0.7 4.2 0.1 0.4 0.1 0.1 1.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 6.1 1.9 2.9 1.4 1.9 0.0 0.8 0.5 0.2 1.8 0.0 0.0 0.0 1.4 0.3 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 1.3 0.0 0.0 0.0 1.4 0.0 6.3 0.0 0.6 0.3 0.0 0.0 0.0 0.0 0.1 0.1 0.1 0.1 0.1 4.5 0.0 23.9 0.0 0.0 0.1 0.1 0.1 0.0 0.9 0.2 0.0 0.5 0.0 0.1 0.4 0.0 0.2 0.1 0.0 0.0 4.2 0.1 0.0 0.0 2.4 0.1 0.0 0.1 0.1 0.1 0.1 1.0 0.1 8.4 7.1 1.4 8.7 5.9 4.9 6.0 4.8 4.2 4.4 AMZ2 ENSG00000196704 "Archaelysin family metallopeptidase 2" Q86W34 17 68247574-68257164 "Enzymes, Predicted intracellular proteins" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA023299, HPA052406" Enhanced Supported "Nucleoplasm,Nuclear bodies,Cytosol" Nucleoplasm "Nuclear bodies, Cytosol" "HPA023299: AB_2226909, HPA052406: " "unprognostic (3.04e-1)" "unprognostic (3.68e-2)" "unprognostic (3.93e-2)" "unprognostic (3.27e-3)" "unprognostic (3.32e-1)" "unprognostic (1.79e-2)" "prognostic unfavourable (1.32e-5)" "unprognostic (2.43e-1)" "unprognostic (3.92e-2)" "unprognostic (2.83e-3)" "unprognostic (3.59e-3)" "unprognostic (3.37e-1)" "prognostic unfavourable (3.14e-4)" "unprognostic (2.37e-1)" "unprognostic (2.95e-1)" "unprognostic (3.28e-1)" "unprognostic (7.62e-2)" 22.3 21.3 29.3 13.7 43.3 14.2 20.8 29.2 35.8 19.8 19.8 20.3 19.6 11.9 19.0 25.3 22.3 24.6 17.7 33.6 26.8 23.7 26.8 16.6 14.1 22.4 26.0 27.0 23.4 20.4 29.4 25.4 18.9 28.3 21.1 15.0 19.0 17.9 25.1 39.9 15.5 13.5 19.3 27.8 16.6 15.7 77.2 20.5 15.5 28.4 20.6 22.4 20.2 14.9 20.9 17.2 31.4 21.1 34.8 31.2 19.7 23.3 25.9 22.0 18.6 16.9 29.5 34.6 16.9 22.9 29.5 24.8 10.6 15.0 35.0 19.1 26.2 11.5 17.9 49.9 38.7 12.3 16.9 12.8 11.5 20.7 32.0 11.7 22.2 25.1 56.0 27.4 51.0 29.8 13.1 22.4 37.2 17.4 26.3 10.9 10.3 24.3 10.0 59.9 26.2 17.7 12.4 22.2 17.4 15.7 32.5 31.6 25.6 8.0 15.5 39.7 18.9 14.2 18.3 31.4 28.8 60.3 28.0 16.6 20.0 31.4 14.4 19.6 22.1 16.6 28.6 17.4 27.3 29.0 17.2 20.9 24.4 26.3 25.2 34.8 21.1 15.7 31.2 19.7 29.3 43.3 29.2 35.8 26.8 23.7 26.0 27.0 28.3 20.5 ANPEP "CD13, gp150, LAP1, p150, PEPN" ENSG00000166825 "Alanyl aminopeptidase, membrane" P15144 15 89784889-89815401 "CD markers, Enzymes, Plasma proteins, Predicted membrane proteins" "Angiogenesis, Differentiation, Host-virus interaction" "Aminopeptidase, Developmental protein, Host cell receptor for virus entry, Hydrolase, Metalloprotease, Protease, Receptor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 195.3;kidney: 78.7;pancreas: 93.9" "Cell line enhanced" "Detected in many" "ASC TERT1: 77.0;BJ: 76.7;BJ hTERT+: 109.7;HMC-1: 69.8;HSkMC: 67.4;HUVEC TERT2: 85.8;TIME: 85.8;U-2197: 93.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in some" "Cell type enriched" "Detected in many" 5 "neutrophil: 59.4" "Lineage enriched" "Detected in many" 5 "granulocytes: 59.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in single" "CAB002417, HPA004625" Enhanced Supported "Plasma membrane" 1500000000 "Plasma membrane" "CAB002417: AB_563491, HPA004625: " "unprognostic (6.31e-2)" "unprognostic (7.94e-3)" "unprognostic (6.91e-2)" "unprognostic (2.16e-1)" "unprognostic (2.50e-1)" "unprognostic (1.13e-1)" "unprognostic (2.23e-2)" "unprognostic (1.89e-1)" "unprognostic (2.50e-1)" "unprognostic (7.73e-2)" "unprognostic (5.28e-3)" "unprognostic (3.96e-1)" "unprognostic (4.04e-3)" "unprognostic (3.20e-2)" "unprognostic (2.01e-2)" "unprognostic (4.61e-3)" "unprognostic (1.99e-2)" 21.3 1.1 0.6 2.9 0.8 9.5 17.0 1.0 1.3 8.2 21.2 0.8 0.5 195.3 1.4 8.4 3.6 1.4 27.7 3.7 0.4 0.3 78.7 37.7 9.7 9.3 0.9 0.9 1.8 93.9 0.0 0.7 14.7 1.3 8.6 4.7 4.0 6.6 1.8 1.6 4.9 155.8 4.3 1.2 7.2 0.8 4.7 0.2 5.6 1.5 4.2 3.8 4.7 3.0 0.0 6.9 59.4 12.8 0.0 0.0 5.5 0.0 4.9 0.0 0.0 60.1 77.0 0.5 76.7 109.7 9.4 8.3 0.5 0.0 0.0 0.9 65.8 0.0 0.5 0.0 3.7 0.0 0.0 14.5 0.4 11.4 35.4 1.0 69.8 67.4 0.1 29.7 0.0 85.8 0.4 0.1 3.6 0.0 0.0 34.1 0.2 5.2 0.0 0.0 0.8 42.9 0.0 0.1 0.7 0.0 0.1 0.0 0.0 6.7 85.8 41.4 0.0 93.5 0.0 0.0 0.0 0.0 0.1 0.0 2.2 5.7 12.8 10.4 0.0 7.0 0.0 0.0 0.0 0.0 6.9 0.0 0.0 0.0 59.4 0.0 12.0 0.1 0.0 5.5 0.6 0.8 1.0 1.3 0.4 0.3 0.9 0.9 1.3 0.2 APEH "D3F15S2, D3S48E, DNF15S2" ENSG00000164062 "Acylaminoacyl-peptide hydrolase" P13798 3 49674002-49683963 "Enzymes, Plasma proteins, Predicted intracellular proteins" Hydrolase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA029700, HPA029701, HPA029702, HPA029703" Enhanced Enhanced Cytosol 1600000 Cytosol "HPA029700: AB_10599278, HPA029701: AB_10600333, HPA029702: AB_10602411, HPA029703: AB_10601348" "unprognostic (4.93e-2)" "unprognostic (5.42e-2)" "unprognostic (6.04e-3)" "unprognostic (2.71e-1)" "unprognostic (9.32e-2)" "unprognostic (8.20e-2)" "unprognostic (3.65e-2)" "unprognostic (2.48e-1)" "unprognostic (5.89e-2)" "unprognostic (8.03e-2)" "unprognostic (3.21e-1)" "unprognostic (4.30e-2)" "prognostic favourable (3.32e-10)" "unprognostic (2.11e-2)" "unprognostic (1.12e-1)" "unprognostic (4.34e-2)" "unprognostic (7.67e-2)" 12.3 31.4 14.3 16.9 18.4 17.3 13.5 14.2 28.2 13.4 23.5 14.4 25.3 24.2 14.1 19.0 23.8 17.2 19.1 23.1 14.2 14.2 33.6 36.9 15.0 23.9 13.9 20.0 13.9 22.7 33.5 26.6 18.6 16.3 16.1 26.6 19.5 19.8 19.8 55.1 16.9 21.7 14.1 9.8 19.2 21.9 22.3 11.7 22.6 26.6 26.6 20.7 19.9 13.7 20.5 26.2 30.4 27.9 21.8 29.5 28.1 25.4 20.8 22.8 29.6 19.9 13.4 30.2 16.6 21.4 23.4 25.1 33.4 27.6 32.6 18.7 18.9 23.6 25.4 38.5 17.8 15.5 10.5 35.1 34.7 27.3 19.8 37.6 54.7 15.2 29.2 13.4 27.8 21.1 21.7 16.2 23.2 23.5 26.5 19.1 13.5 19.0 10.1 19.6 42.3 46.3 60.4 10.9 18.9 18.8 45.7 20.7 30.1 20.1 9.6 14.5 25.4 22.6 22.4 18.6 13.2 19.4 25.0 26.6 20.8 30.2 25.5 30.4 28.5 27.9 22.5 20.5 23.5 26.7 26.2 17.4 24.9 24.2 8.0 21.8 26.7 21.0 29.5 28.1 14.3 18.4 14.2 28.2 14.2 14.2 13.9 20.0 16.3 11.7 ASTL "ovastacin, SAS1B" ENSG00000188886 "Astacin like metalloendopeptidase" Q6HA08 2 96123850-96138436 "Enzymes, Predicted secreted proteins" Fertilization "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "bone marrow: 8.5" "Cell line enhanced" "Detected in some" "BEWO: 3.1;fHDF/TERT166: 2.1;RT4: 3.8" "Low cancer specificity" "Detected in single" "Low cell type specificity" "Detected in some" "Group enriched" "Detected in many" 5 "NK-cells: 1.9;T-cells: 1.8" "Not detected" "Not detected" "Not detected" "Not detected" HPA015620 Uncertain "Secreted in female reproductive system" "HPA015620: AB_1845121" "unprognostic (3.21e-2)" "unprognostic (1.45e-2)" "unprognostic (3.87e-2)" "unprognostic (3.45e-4)" "unprognostic (1.00e-2)" "unprognostic (3.03e-2)" "unprognostic (3.53e-2)" "unprognostic (5.12e-2)" "unprognostic (3.62e-1)" "unprognostic (3.40e-1)" "unprognostic (1.95e-1)" "unprognostic (2.61e-5)" "unprognostic (3.41e-3)" "unprognostic (1.08e-1)" "unprognostic (1.67e-1)" "unprognostic (9.93e-3)" 0.2 0.1 0.2 0.6 0.4 8.5 0.1 1.3 0.8 0.0 0.5 0.1 0.3 0.4 0.5 0.0 0.4 0.0 0.8 0.0 0.1 0.0 0.5 1.1 0.0 0.2 0.0 0.0 0.8 0.0 0.9 0.2 0.6 2.7 0.0 2.3 1.1 0.0 0.0 2.3 0.2 0.7 0.0 0.7 3.2 0.0 0.3 0.0 0.0 0.0 1.9 1.8 0.3 0.0 0.0 0.0 0.1 0.0 0.4 3.1 0.0 0.0 0.0 0.1 1.2 0.1 0.1 1.2 2.1 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.5 1.1 0.9 0.7 0.0 0.0 0.0 0.4 0.0 3.8 0.8 0.0 0.0 0.3 0.3 1.4 0.5 0.0 0.0 0.4 0.0 0.0 0.2 0.0 0.5 0.0 0.2 0.2 0.0 0.0 0.0 0.5 0.0 1.2 0.3 1.8 1.8 0.0 0.0 0.3 0.6 0.0 1.9 0.0 0.0 0.0 0.3 ATG4A "APG4A, AUTL2" ENSG00000101844 "Autophagy related 4A cysteine peptidase" Q8WYN0 X 108091668-108154671 "Enzymes, Predicted intracellular proteins" "Autophagy, Protein transport, Transport, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HUVEC TERT2: 40.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA036374, HPA064759" Uncertain Approved "Actin filaments,Microtubules" Microtubules "Actin filaments" "HPA036374: AB_10672354, HPA064759: " "prognostic unfavourable (1.36e-5)" "unprognostic (1.41e-2)" "unprognostic (3.65e-1)" "unprognostic (2.52e-1)" "unprognostic (1.28e-1)" "unprognostic (1.79e-1)" "unprognostic (1.18e-1)" "unprognostic (2.83e-3)" "unprognostic (2.23e-1)" "unprognostic (3.14e-1)" "unprognostic (2.62e-2)" "unprognostic (4.09e-1)" "unprognostic (1.03e-3)" "unprognostic (7.53e-2)" "unprognostic (2.98e-1)" "unprognostic (5.02e-3)" "unprognostic (1.20e-2)" 8.2 11.8 6.4 6.1 8.0 6.1 7.4 9.7 6.2 6.8 10.0 5.5 8.6 10.3 6.9 10.4 10.6 5.4 6.5 10.9 4.3 3.2 15.3 23.4 10.8 8.2 6.9 5.7 4.7 22.3 8.2 13.1 7.9 7.2 6.6 11.3 6.7 17.2 6.2 18.8 6.3 18.7 7.2 6.7 10.5 12.9 3.1 8.2 12.0 12.0 7.4 10.5 7.4 7.8 8.7 9.8 18.7 9.9 10.0 11.9 7.4 5.8 2.9 1.9 3.6 18.4 6.3 2.3 8.2 5.1 4.2 5.0 2.3 3.3 6.4 7.4 6.5 2.8 5.5 6.0 6.4 10.8 6.1 2.7 5.1 1.5 4.0 5.7 8.9 6.5 6.3 5.2 2.1 40.1 8.3 20.5 7.7 5.3 5.4 5.3 3.5 8.4 3.7 3.2 9.3 6.2 5.2 2.7 2.1 5.2 6.4 3.4 3.2 5.3 11.0 2.5 1.2 9.0 4.4 9.5 10.8 6.9 5.2 6.6 3.7 18.7 7.0 13.1 11.6 9.9 8.3 8.7 8.9 10.9 9.8 7.6 7.0 11.9 2.2 10.0 6.7 4.6 9.2 7.4 6.4 8.0 9.7 6.2 4.3 3.2 6.9 5.7 7.2 8.2 ATG4B "Apg4B, AUTL1, DKFZp586D1822, KIAA0943" ENSG00000168397 "Autophagy related 4B cysteine peptidase" Q9Y4P1 2 241637213-241673857 "Enzymes, Predicted intracellular proteins, Transporters" "Autophagy, Protein transport, Transport, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB037195, HPA069803" Approved Approved Nucleoplasm,Cytosol "Nucleoplasm, Cytosol" "CAB037195: AB_1078237, HPA069803: " "unprognostic (1.51e-1)" "unprognostic (8.80e-2)" "prognostic unfavourable (6.85e-4)" "unprognostic (1.51e-1)" "unprognostic (2.43e-2)" "unprognostic (2.67e-3)" "unprognostic (1.07e-3)" "unprognostic (1.06e-1)" "unprognostic (1.61e-1)" "unprognostic (1.58e-1)" "unprognostic (1.15e-3)" "unprognostic (3.02e-2)" "prognostic unfavourable (2.79e-4)" "unprognostic (2.60e-1)" "unprognostic (6.63e-2)" "unprognostic (1.66e-1)" "prognostic favourable (9.64e-4)" 10.9 16.5 19.6 16.6 21.3 31.3 15.1 34.8 25.7 13.5 18.7 21.7 23.2 14.6 33.5 24.0 26.7 17.7 18.8 19.5 20.5 21.5 17.2 15.5 15.8 19.4 29.2 19.7 17.3 19.2 18.7 27.4 15.4 20.3 20.5 18.9 20.8 22.8 14.2 17.2 26.6 21.1 18.9 23.1 18.7 15.5 28.0 21.4 21.2 18.2 7.3 21.9 15.3 14.4 16.5 20.3 18.9 18.6 11.4 19.6 16.8 8.6 13.4 19.2 14.9 19.3 14.1 19.1 12.7 13.8 16.4 13.6 14.7 15.3 6.6 5.7 22.7 12.7 18.3 24.1 16.0 14.1 18.6 19.5 21.7 31.8 25.1 11.2 11.0 13.9 16.8 18.4 17.8 16.9 16.6 10.2 18.6 21.1 20.2 19.9 22.4 14.4 34.8 17.7 10.0 12.9 28.0 19.3 13.4 10.8 14.4 15.1 15.9 16.6 18.4 15.7 10.7 10.4 13.6 11.5 12.0 25.4 19.0 14.1 14.6 4.6 18.6 18.9 18.7 15.5 15.5 15.7 15.2 16.5 20.3 16.5 19.6 14.7 14.8 11.4 16.2 16.3 19.3 16.8 19.6 21.3 34.8 25.7 20.5 21.5 29.2 19.7 20.3 21.4 ATG4C "APG4C, AUTL1, AUTL3, FLJ14867" ENSG00000125703 "Autophagy related 4C cysteine peptidase" Q96DT6 1 62784135-62865513 "Enzymes, Predicted intracellular proteins" "Autophagy, Protein transport, Transport, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA007049 Approved Approved Nucleoplasm,Cytosol "Nucleoplasm, Cytosol" "HPA007049: AB_1845159" "unprognostic (1.28e-1)" "unprognostic (2.69e-1)" "prognostic favourable (9.83e-4)" "unprognostic (7.43e-2)" "unprognostic (1.17e-1)" "unprognostic (1.70e-1)" "unprognostic (3.76e-2)" "unprognostic (8.36e-2)" "unprognostic (1.83e-2)" "unprognostic (1.30e-1)" "unprognostic (3.77e-1)" "unprognostic (1.93e-1)" "unprognostic (5.66e-2)" "unprognostic (1.81e-1)" "unprognostic (4.17e-2)" "unprognostic (3.26e-2)" "unprognostic (1.19e-1)" 8.8 9.8 19.4 11.3 32.8 6.0 9.2 16.7 23.4 10.6 9.5 29.8 7.2 7.7 9.6 7.2 8.6 8.0 10.4 7.2 23.7 15.5 13.5 12.6 9.2 13.7 42.6 16.5 10.3 11.2 15.5 11.3 15.0 22.4 8.0 10.6 4.9 10.8 8.0 6.4 6.3 7.8 11.2 26.5 13.3 8.6 8.9 40.4 11.0 12.0 3.7 12.4 13.4 6.8 20.6 19.4 16.0 10.9 7.0 9.4 6.7 7.6 6.1 9.5 8.3 12.5 13.5 9.5 11.5 7.8 11.1 12.5 4.5 6.1 16.3 8.9 5.8 5.9 11.3 8.7 16.1 12.2 10.4 18.3 6.5 5.8 8.9 14.8 12.3 11.1 6.2 11.8 5.6 13.3 15.5 13.3 9.3 3.6 14.9 5.7 13.9 10.1 17.9 22.8 11.5 8.0 5.6 12.9 6.5 7.6 14.4 14.8 7.0 7.0 5.2 8.9 8.7 15.0 12.6 11.6 15.6 13.3 10.2 14.7 10.7 16.0 10.9 8.5 4.8 8.8 6.6 20.6 6.6 5.6 19.4 19.1 9.4 7.7 1.6 7.0 5.0 11.6 5.7 6.7 19.4 32.8 16.7 23.4 23.7 15.5 42.6 16.5 22.4 40.4 ATG4D "APG4-D, APG4D, AUTL4" ENSG00000130734 "Autophagy related 4D cysteine peptidase" Q86TL0 19 10543895-10553418 "Enzymes, Predicted intracellular proteins, Transporters" "Apoptosis, Autophagy, Protein transport, Transport, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA067683 Approved Supported Nucleoplasm,Mitochondria "Nucleoplasm, Mitochondria" "HPA067683: " "unprognostic (2.85e-1)" "prognostic favourable (3.18e-5)" "unprognostic (2.73e-1)" "unprognostic (3.67e-1)" "unprognostic (2.18e-1)" "unprognostic (1.15e-2)" "unprognostic (3.52e-2)" "unprognostic (1.23e-1)" "unprognostic (4.28e-2)" "unprognostic (7.30e-2)" "prognostic favourable (9.95e-4)" "unprognostic (1.52e-1)" "prognostic favourable (2.39e-7)" "prognostic favourable (5.03e-4)" "unprognostic (3.78e-2)" "unprognostic (2.29e-1)" "unprognostic (3.18e-3)" 6.4 10.8 5.1 9.2 7.8 35.0 6.3 15.6 14.9 6.2 18.4 9.8 8.1 26.0 6.1 7.2 18.4 5.5 7.6 15.4 4.6 4.9 14.5 8.8 7.3 9.8 9.6 6.4 7.0 16.1 8.2 12.1 6.9 7.3 9.7 7.3 7.8 11.5 8.5 31.5 17.7 27.3 4.0 4.5 12.0 10.5 29.0 8.8 19.9 9.8 16.4 10.5 7.5 9.6 2.0 7.6 5.7 1.6 2.2 3.6 1.4 6.9 4.7 6.5 8.8 1.2 1.0 5.1 4.3 4.3 6.1 6.8 7.8 2.3 4.5 8.2 0.5 11.0 4.0 3.7 0.8 4.4 10.6 11.9 11.4 4.3 4.1 4.7 12.2 1.0 7.7 5.3 1.9 1.8 8.8 10.9 1.9 11.2 14.0 29.1 9.9 12.8 10.3 4.0 8.0 3.5 9.4 24.6 9.5 6.3 12.4 4.9 7.6 11.7 3.4 9.4 5.9 18.9 9.5 9.7 6.6 5.3 8.0 9.3 10.6 3.0 1.6 5.7 2.1 1.5 3.1 2.0 2.5 2.3 1.1 1.0 2.5 3.4 0.5 2.2 0.7 7.6 3.6 1.4 5.1 7.8 15.6 14.9 4.6 4.9 9.6 6.4 7.3 8.8 ATP23 "KUB3, XRCC6BP1" ENSG00000166896 "ATP23 metallopeptidase and ATP synthase assembly factor homolog" Q9Y6H3 12 57941541-57957269 "Enzymes, Predicted intracellular proteins" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "testis: 39.5" "Cell line enhanced" "Detected in many" "NB-4: 14.8;RH-30: 48.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA035804, HPA043204" Uncertain Enhanced "Vesicles,Plasma membrane,Cell Junctions,Cytosol" "Vesicles, Plasma membrane" "Cell Junctions, Cytosol" "HPA035804: AB_10601026, HPA043204: " "unprognostic (2.56e-1)" "unprognostic (1.31e-2)" "unprognostic (8.82e-2)" "unprognostic (2.92e-2)" "unprognostic (2.30e-2)" "unprognostic (6.16e-2)" "unprognostic (1.20e-1)" "unprognostic (5.28e-2)" "unprognostic (5.41e-3)" "unprognostic (1.03e-2)" "unprognostic (1.24e-1)" "unprognostic (1.06e-1)" "prognostic unfavourable (1.44e-5)" "unprognostic (4.36e-2)" "unprognostic (1.12e-1)" "unprognostic (1.80e-1)" "unprognostic (2.27e-1)" 6.7 4.9 4.3 5.2 5.3 11.3 4.8 6.1 4.8 5.6 8.2 1.3 2.5 3.9 3.2 4.2 7.3 3.1 2.4 6.4 4.2 3.6 5.4 6.2 2.7 6.8 2.7 3.8 4.2 5.8 3.2 3.0 3.5 2.9 5.1 8.2 2.3 3.4 3.3 11.7 5.6 4.3 6.5 3.4 3.7 3.8 39.5 2.0 20.8 4.7 5.9 4.7 6.3 6.2 3.0 4.5 12.0 4.5 2.6 5.6 3.0 1.9 1.5 1.9 2.2 2.8 2.7 1.0 1.9 1.9 2.2 2.1 1.2 2.4 6.8 2.4 1.4 1.8 1.8 1.9 3.8 3.4 1.8 4.4 1.2 1.9 1.2 8.9 3.0 1.4 1.5 1.3 0.5 1.5 4.6 4.9 1.8 3.0 4.8 14.8 1.6 3.7 3.1 48.8 2.8 1.8 2.5 1.2 1.8 3.0 2.8 1.5 4.9 8.4 0.8 1.6 2.8 2.1 1.8 4.0 2.1 3.5 1.8 9.6 2.7 7.6 4.5 12.0 3.5 2.4 2.6 3.0 4.0 3.3 4.5 3.0 4.3 4.0 1.9 2.6 4.2 2.1 5.6 3.0 4.3 5.3 6.1 4.8 4.2 3.6 2.7 3.8 2.9 2.0 AZU1 "AZAMP, AZU, CAP37, HBP, HUMAZUR, NAZC" ENSG00000172232 "Azurocidin 1" P20160 19 825097-832018 "Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" Chemotaxis "Antibiotic, Antimicrobial, Heparin-binding, Serine protease homolog" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 7 "bone marrow: 238.2" "Cell line enriched" "Detected in some" 7 "THP-1: 150.8" "Low cancer specificity" "Detected in some" "Not detected" "Not detected" "Group enriched" "Detected in some" 6 "classical monocyte: 3.3;neutrophil: 7.6" "Group enriched" "Detected in many" 6 "granulocytes: 7.6;monocytes: 3.3" "Not detected" "Not detected" "HPA055851, HPA075964" Enhanced Enhanced Vesicles "Secreted to blood" 290000 Vesicles "HPA055851: , HPA075964: " "unprognostic (1.12e-2)" "unprognostic (3.71e-2)" "unprognostic (4.44e-2)" "unprognostic (8.85e-3)" "unprognostic (1.62e-2)" "unprognostic (1.29e-1)" "unprognostic (1.39e-1)" "unprognostic (8.12e-2)" "unprognostic (3.32e-1)" "unprognostic (4.22e-3)" "unprognostic (2.58e-1)" "unprognostic (1.50e-1)" "unprognostic (1.01e-6)" "unprognostic (1.11e-2)" "unprognostic (1.10e-1)" "unprognostic (2.46e-2)" "unprognostic (3.04e-2)" 0.3 0.2 0.4 0.2 0.5 238.2 0.6 0.0 0.6 0.2 0.2 1.0 0.0 0.2 0.2 0.2 0.2 0.8 0.2 34.6 0.4 0.5 0.2 1.5 15.3 0.2 0.2 0.0 0.5 0.1 0.1 0.9 3.8 0.2 0.2 0.2 0.2 0.6 0.2 1.0 0.4 0.2 0.2 0.1 18.6 0.2 1.2 0.0 20.6 1.3 0.0 0.2 0.1 0.4 0.0 0.8 7.6 3.3 0.0 0.3 4.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 17.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 150.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 21.0 0.0 0.0 3.3 0.2 0.3 0.8 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 7.6 0.0 0.5 0.0 0.0 4.1 0.4 0.5 0.0 0.6 0.4 0.5 0.2 0.0 0.2 0.0 BACE1 BACE ENSG00000186318 "Beta-secretase 1" P56817 11 117285207-117316259 "Enzymes, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Aspartyl protease, Hydrolase, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in all" 8 "brain: 53.0;pancreas: 161.1" "Cell line enhanced" "Detected in many" "fHDF/TERT166: 38.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" CAB016358 Approved Supported "Plasma membrane" "Plasma membrane" "CAB016358: AB_626716" "unprognostic (7.96e-3)" "unprognostic (8.05e-2)" "unprognostic (3.55e-2)" "unprognostic (3.05e-3)" "unprognostic (8.94e-2)" "unprognostic (3.39e-1)" "unprognostic (1.03e-1)" "unprognostic (2.60e-1)" "unprognostic (4.54e-2)" "unprognostic (8.04e-2)" "unprognostic (8.09e-2)" "unprognostic (1.09e-1)" "unprognostic (1.12e-1)" "unprognostic (1.35e-2)" "unprognostic (1.16e-1)" "unprognostic (1.27e-1)" "prognostic unfavourable (6.76e-4)" 6.5 7.1 12.1 3.8 18.8 2.2 5.5 9.6 22.4 9.8 4.6 42.5 2.7 3.4 9.3 5.6 7.6 8.6 9.1 5.9 16.9 12.4 6.8 12.1 7.3 2.8 28.8 15.0 11.4 161.1 12.8 4.2 6.3 26.4 6.5 4.7 6.9 5.3 9.9 6.2 7.2 3.6 11.7 53.0 5.7 4.9 4.1 21.4 0.0 6.3 2.3 2.8 6.7 5.5 4.0 2.2 0.7 3.2 2.2 6.7 1.1 3.9 4.6 9.6 14.7 32.0 34.5 0.4 21.2 18.5 10.3 8.4 3.6 6.2 0.7 5.2 38.3 6.9 10.3 6.1 8.5 2.3 5.5 2.3 7.9 4.3 15.8 0.8 0.5 29.9 9.5 13.2 12.8 8.9 0.8 0.4 18.9 14.2 0.6 1.9 6.2 10.4 1.8 4.3 0.8 4.4 2.2 12.5 14.0 7.9 1.0 2.3 10.2 2.7 12.1 18.6 2.0 19.4 6.8 0.3 0.3 0.4 8.7 1.2 13.0 0.6 2.0 0.7 2.0 3.2 5.2 4.0 6.7 5.3 2.2 1.8 3.1 2.7 0.0 2.2 1.3 1.3 6.3 1.1 12.1 18.8 9.6 21.7 16.9 12.4 28.8 15.0 26.4 21.4 BACE2 "AEPLC, ALP56, CEAP1, DRAP" ENSG00000182240 "Beta-site APP-cleaving enzyme 2" Q9Y5Z0 21 41167801-41282518 "Enzymes, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Aspartyl protease, Hydrolase, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell line enhanced" "Detected in many" "A-431: 16.9;SK-BR-3: 28.6;SK-MEL-30: 22.2;WM-115: 20.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Group enriched" "Detected in some" 6 "basophil: 4.8;eosinophil: 8.4" "Lineage enriched" "Detected in many" 8 "granulocytes: 8.4" "Low region specificity" "Detected in all" HPA035416 Approved "Intracellular and membrane" "HPA035416: " "unprognostic (1.71e-2)" "prognostic unfavourable (1.11e-4)" "unprognostic (5.23e-2)" "unprognostic (8.12e-3)" "prognostic unfavourable (5.86e-4)" "unprognostic (1.52e-2)" "unprognostic (2.58e-2)" "unprognostic (2.64e-3)" "unprognostic (7.24e-2)" "unprognostic (2.49e-1)" "unprognostic (3.46e-2)" "unprognostic (8.50e-2)" "unprognostic (1.22e-1)" "unprognostic (4.04e-1)" "unprognostic (2.10e-1)" "unprognostic (2.76e-2)" "unprognostic (5.83e-2)" 16.1 2.5 1.4 5.9 1.6 0.9 13.8 0.9 2.0 9.0 11.0 3.4 5.6 5.1 10.3 10.7 13.0 6.8 38.9 7.2 1.7 1.6 11.4 4.4 4.9 21.6 2.7 0.5 8.4 29.0 3.3 2.2 17.2 4.4 22.7 7.4 8.7 28.3 4.4 10.6 5.5 5.4 7.8 5.9 7.0 31.6 5.1 1.4 1.3 9.9 7.6 14.3 11.8 33.6 1.0 0.0 8.4 0.0 0.3 0.0 0.0 16.9 1.6 5.7 0.0 1.5 1.6 0.0 4.2 0.0 2.9 2.5 0.0 6.5 0.0 8.0 5.3 5.3 0.0 10.0 1.0 0.0 8.4 3.3 1.9 0.0 0.7 0.0 8.0 4.1 1.9 0.3 2.1 8.4 0.0 0.0 4.0 3.1 1.9 0.0 4.4 8.7 0.6 0.0 6.3 5.2 1.1 0.2 0.0 0.3 28.6 22.2 8.0 0.0 8.3 4.7 3.4 3.8 6.0 0.0 0.0 0.0 9.8 0.0 20.3 4.8 0.0 8.4 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 1.4 1.6 0.9 2.0 1.7 1.6 2.7 0.5 4.4 1.4 BAP1 "hucep-6, KIAA0272, UCHL2" ENSG00000163930 "BRCA1 associated protein 1" Q92560 3 52401013-52410350 "Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" "Ubl conjugation pathway" "Chromatin regulator, Hydrolase, Protease, Thiol protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004322, HPA028814, HPA028815, HPA055560" Approved Enhanced Nucleoplasm,Cytosol Nucleoplasm Cytosol "CAB004322: AB_626723, HPA028814: AB_10602393, HPA028815: , HPA055560: " "unprognostic (1.52e-1)" "unprognostic (7.96e-2)" "unprognostic (1.96e-2)" "unprognostic (6.04e-2)" "unprognostic (1.74e-1)" "unprognostic (2.55e-2)" "unprognostic (9.41e-3)" "unprognostic (8.53e-3)" "unprognostic (1.33e-1)" "unprognostic (3.15e-1)" "unprognostic (4.64e-3)" "unprognostic (3.30e-3)" "prognostic favourable (3.29e-7)" "unprognostic (6.37e-2)" "unprognostic (1.91e-1)" "unprognostic (5.54e-2)" "unprognostic (2.92e-1)" 13.8 17.6 35.6 14.7 33.3 37.3 13.5 21.8 50.4 12.5 17.0 16.3 11.5 12.4 14.7 14.6 21.2 12.1 15.7 16.4 41.5 15.5 16.6 19.0 14.9 15.2 19.4 27.6 16.9 16.3 30.0 11.1 14.8 19.6 14.4 14.9 15.6 17.9 14.6 24.8 40.5 13.9 14.5 10.0 16.1 13.3 37.3 14.7 18.6 15.3 12.9 16.0 14.1 11.7 5.5 8.4 11.3 5.0 3.0 8.5 3.9 15.3 17.5 21.2 18.0 20.5 13.2 23.9 15.2 19.7 24.7 19.2 21.1 14.4 22.0 7.6 21.2 12.5 22.3 24.5 15.8 21.8 21.1 27.3 37.0 21.8 19.1 25.6 24.3 19.7 32.9 27.3 14.7 19.7 23.3 19.5 18.6 13.3 30.3 35.1 23.9 21.3 13.1 17.2 21.7 15.2 24.9 8.1 26.1 18.7 5.4 22.2 15.3 35.4 21.1 22.4 20.6 26.8 28.2 29.6 38.9 31.5 24.4 27.0 26.4 3.4 5.0 7.4 8.5 3.9 4.0 5.0 6.8 6.9 3.3 5.5 4.9 6.4 11.3 3.0 3.1 8.4 6.0 3.9 35.6 33.3 21.8 50.4 41.5 15.5 19.4 27.6 19.6 14.7 BLMH BH ENSG00000108578 "Bleomycin hydrolase" Q13867 17 30248195-30292056 "Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skin 1: 67.5" "Low cell line specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low region specificity" "Detected in all" "HPA039548, HPA064307" Enhanced Supported "Nucleoplasm,Nuclear bodies,Cytosol" 59000000 "Nucleoplasm, Nuclear bodies, Cytosol" "HPA039548: AB_10805479, HPA064307: AB_2685241" "unprognostic (6.85e-2)" "unprognostic (2.79e-1)" "unprognostic (1.48e-1)" "unprognostic (2.46e-1)" "unprognostic (1.76e-1)" "unprognostic (2.54e-2)" "unprognostic (3.91e-3)" "unprognostic (2.07e-1)" "unprognostic (2.05e-3)" "unprognostic (6.69e-3)" "unprognostic (1.95e-3)" "unprognostic (2.14e-2)" "unprognostic (2.14e-2)" "unprognostic (1.22e-3)" "unprognostic (1.05e-1)" "unprognostic (1.34e-1)" "unprognostic (1.44e-1)" 11.2 8.3 9.0 17.1 10.2 8.5 14.2 12.1 14.5 10.5 9.8 8.5 9.6 6.7 13.1 12.2 15.7 8.4 10.1 9.7 7.5 7.2 13.6 7.5 13.6 20.3 9.5 8.5 8.8 15.3 15.0 8.3 14.6 9.2 8.4 8.5 7.3 12.8 9.5 15.0 67.5 10.0 15.7 11.1 13.2 9.2 12.4 8.6 24.7 9.3 15.5 13.6 10.8 11.7 4.6 6.6 0.9 5.7 9.8 17.3 6.3 10.1 16.1 15.6 10.8 10.7 11.5 7.5 9.5 5.9 15.0 13.0 23.6 3.0 30.3 17.0 7.6 7.1 33.7 13.0 12.7 8.0 26.5 18.6 14.5 20.0 15.6 33.8 11.5 13.5 0.9 11.7 6.8 22.0 39.6 12.4 6.2 7.7 41.8 24.7 14.9 7.5 36.3 40.5 20.0 12.0 9.1 36.0 12.9 8.4 16.4 10.3 11.2 17.5 14.0 9.3 18.7 4.1 16.8 15.0 30.8 40.9 7.1 0.0 12.4 0.0 5.7 0.9 10.5 3.9 17.3 4.6 12.6 13.7 6.5 4.2 11.6 12.3 0.7 9.8 1.9 6.6 12.4 6.3 9.0 10.2 12.1 14.5 7.5 7.2 9.5 8.5 9.2 8.6 BMP1 PCOLC ENSG00000168487 "Bone morphogenetic protein 1" P13497 8 22164736-22212326 "Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted secreted proteins" "Chondrogenesis, Differentiation, Osteogenesis" "Cytokine, Developmental protein, Growth factor, Hydrolase, Metalloprotease, Protease" "Disease mutation, Osteogenesis imperfecta" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in all" 8 "lung: 72.2;placenta: 106.2" "Low cell line specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA014572 Enhanced "Secreted to extracellular matrix" 2100000 "HPA014572: AB_1845390" "unprognostic (1.24e-1)" "unprognostic (8.01e-2)" "unprognostic (3.75e-2)" "unprognostic (5.89e-2)" "unprognostic (1.34e-2)" "unprognostic (6.76e-2)" "unprognostic (9.53e-2)" "unprognostic (2.64e-3)" "unprognostic (1.66e-1)" "unprognostic (9.75e-3)" "unprognostic (7.05e-3)" "unprognostic (3.14e-2)" "prognostic unfavourable (3.37e-9)" "unprognostic (2.11e-2)" "unprognostic (6.57e-2)" "unprognostic (1.50e-3)" "unprognostic (3.34e-2)" 6.9 11.7 2.7 3.6 4.6 1.1 5.9 7.8 4.2 8.1 5.8 3.1 3.7 4.4 9.4 5.2 4.8 7.7 5.4 3.4 2.6 1.3 4.9 9.2 72.2 3.2 3.4 1.5 5.2 3.7 2.8 2.2 106.2 3.5 6.5 4.7 4.6 2.4 4.6 2.4 6.8 5.7 11.0 3.6 3.2 2.9 2.2 3.6 1.0 7.1 2.4 2.9 9.9 9.5 0.0 0.9 0.1 1.4 0.8 2.2 0.4 4.6 4.8 1.3 6.2 15.3 11.3 6.8 20.3 16.9 10.4 9.6 2.5 3.0 1.1 12.7 18.6 10.2 1.6 5.4 2.0 1.0 2.1 1.7 7.3 2.9 12.5 0.7 3.5 12.9 8.5 8.1 2.6 10.0 2.2 2.1 5.6 1.7 0.5 1.0 0.8 2.6 1.1 3.3 4.9 9.0 0.7 0.8 3.3 14.6 0.8 3.3 0.9 2.0 12.7 2.7 6.0 6.5 6.0 1.0 0.6 0.2 5.3 2.7 7.5 0.0 1.4 0.0 2.2 0.7 1.4 0.0 0.4 1.0 0.0 0.0 0.3 1.7 0.1 0.8 0.5 0.9 0.0 0.4 2.7 4.6 7.8 4.2 2.6 1.3 3.4 1.5 3.5 3.6 BRCC3 "BRCC36, C6.1A, CXorf53" ENSG00000185515 "BRCA1/BRCA2-containing complex subunit 3" P46736 X 155071420-155123074 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" "Cell cycle, Cell division, DNA damage, DNA repair, Mitosis, Ubl conjugation pathway" "Chromatin regulator, Hydrolase, Metalloprotease, Protease" Proto-oncogene "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" HPA048737 Supported Nucleoplasm Nucleoplasm "HPA048737: " "unprognostic (1.16e-2)" "unprognostic (2.40e-2)" "unprognostic (5.99e-2)" "unprognostic (1.53e-1)" "unprognostic (1.43e-1)" "unprognostic (2.88e-2)" "unprognostic (4.48e-2)" "unprognostic (6.47e-3)" "unprognostic (1.33e-1)" "unprognostic (9.68e-2)" "unprognostic (1.35e-3)" "unprognostic (3.72e-2)" "unprognostic (3.71e-3)" "unprognostic (7.14e-3)" "unprognostic (1.57e-1)" "unprognostic (1.17e-1)" "unprognostic (1.90e-1)" 12.9 14.8 11.3 11.2 16.5 14.0 12.9 20.0 18.6 11.8 19.5 9.1 15.2 16.7 9.4 11.8 20.4 12.1 8.3 10.3 10.3 12.1 18.3 12.3 9.4 12.5 10.4 10.5 10.7 12.2 14.3 11.8 14.2 15.3 12.2 19.5 8.7 15.5 12.6 21.3 10.0 19.2 13.1 8.9 11.1 13.7 3.9 12.9 10.2 13.9 13.7 12.7 11.4 11.6 13.4 16.2 25.0 17.8 21.0 19.0 12.3 31.4 19.5 8.2 6.4 6.2 5.1 13.6 12.9 8.2 7.9 17.5 17.6 13.8 30.3 23.6 8.2 12.2 21.1 11.5 11.5 17.6 16.9 6.1 30.7 14.6 5.5 21.4 9.5 6.3 5.2 12.9 11.0 10.8 9.9 9.0 6.4 13.3 8.2 7.6 7.3 13.9 12.9 14.1 12.6 9.5 14.9 13.5 5.8 8.5 13.6 7.7 9.4 7.3 12.1 7.1 10.9 10.4 19.4 11.5 18.7 39.4 10.3 20.1 8.2 22.6 14.7 25.0 16.2 17.8 19.0 13.4 16.0 14.8 16.2 11.8 12.5 14.0 8.0 21.0 16.9 10.4 18.6 12.3 11.3 16.5 20.0 18.6 10.3 12.1 10.4 10.5 15.3 12.9 C1R ENSG00000159403 "Complement C1r" P00736 12 7080209-7092607 "Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Complement pathway, Immunity, Innate immunity" "Hydrolase, Protease, Serine protease" "Disease mutation, Ehlers-Danlos syndrome, FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "liver: 370.2" "Cell line enhanced" "Detected in many" "ASC diff: 177.7;ASC TERT1: 90.7;BJ hTERT+: 78.2;BJ hTERT+ SV40 Large T+ RasG12V: 48.2;HSkMC: 105.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 5 "eosinophil: 2.0;gdT-cell: 1.6;MAIT T-cell: 2.0;memory CD4 T-cell: 1.4;memory CD8 T-cell: 3.4;naive CD4 T-cell: 2.8;naive CD8 T-cell: 2.9;neutrophil: 2.5;NK-cell: 3.2;T-reg: 1.4" "Group enriched" "Detected in many" 6 "granulocytes: 2.5;NK-cells: 3.2;T-cells: 3.4" "Low region specificity" "Detected in all" "HPA001251, HPA001551" Uncertain Uncertain Nucleoplasm,Cytosol "Secreted to blood" 14000000000 "Nucleoplasm, Cytosol" "HPA001251: , HPA001551: AB_10754818" "unprognostic (1.55e-2)" "unprognostic (8.97e-2)" "unprognostic (3.46e-2)" "unprognostic (1.92e-1)" "unprognostic (1.47e-2)" "unprognostic (2.66e-2)" "unprognostic (1.94e-2)" "unprognostic (2.05e-1)" "unprognostic (2.50e-1)" "unprognostic (1.72e-1)" "unprognostic (1.21e-1)" "unprognostic (4.16e-2)" "prognostic unfavourable (1.94e-14)" "unprognostic (3.54e-2)" "unprognostic (2.25e-2)" "unprognostic (6.13e-2)" "unprognostic (2.59e-2)" 45.8 17.4 2.6 18.1 3.8 0.0 82.0 1.4 2.8 36.7 24.5 2.4 11.2 5.0 27.2 66.8 38.1 33.3 46.7 49.5 1.9 1.8 27.5 370.2 25.3 46.8 3.5 2.0 103.5 11.4 1.4 6.3 10.3 4.6 47.8 15.3 17.7 12.8 13.2 16.0 10.7 14.4 53.2 6.2 35.1 19.8 39.3 1.9 2.3 30.6 20.7 15.1 46.8 83.8 0.4 0.0 2.5 0.4 3.2 3.4 0.8 0.1 1.5 0.1 1.3 177.7 90.7 0.1 19.9 78.2 23.7 48.2 0.2 0.3 0.0 0.6 15.6 0.2 1.7 0.8 3.3 1.8 0.1 0.0 0.6 0.6 34.2 0.1 0.2 105.0 0.5 10.8 0.8 0.4 0.0 2.5 3.1 0.0 0.8 0.1 0.8 0.1 1.1 0.5 0.1 0.1 0.9 0.0 0.3 14.4 0.4 0.4 0.0 0.0 0.0 5.6 0.9 26.1 0.1 0.1 0.4 0.0 8.1 0.1 0.8 0.0 0.4 2.0 1.6 0.1 2.0 0.0 1.4 3.4 0.0 0.4 2.8 2.9 2.5 3.2 0.0 0.0 1.4 0.8 2.6 3.8 1.4 2.8 1.9 1.8 3.5 2.0 4.6 1.9 C1RL "C1r-LP, C1RL1" ENSG00000139178 "Complement C1r subcomponent like" Q9NZP8 12 7089587-7109273 "Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Complement pathway, Immunity, Innate immunity" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 96.1" "Cell line enhanced" "Detected in many" "ASC TERT1: 31.6;HSkMC: 35.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Cell type enhanced" "Detected in many" "neutrophil: 11.7" "Lineage enriched" "Detected in many" 5 "granulocytes: 11.7" "Low region specificity" "Detected in single" "Low region specificity" "Detected in all" "HPA011338, CAB026172" Supported Approved Microtubules,Cytosol "Secreted to blood" 5500000000 20000000000 Microtubules Cytosol "CAB026172: , HPA011338: AB_1847111" "prognostic favourable (7.92e-4)" "unprognostic (7.76e-2)" "unprognostic (3.91e-3)" "unprognostic (5.25e-3)" "unprognostic (2.92e-3)" "unprognostic (9.60e-2)" "unprognostic (2.75e-3)" "unprognostic (7.76e-2)" "unprognostic (1.22e-1)" "unprognostic (4.34e-1)" "unprognostic (9.58e-3)" "unprognostic (1.57e-1)" "prognostic unfavourable (1.52e-7)" "unprognostic (1.75e-1)" "unprognostic (5.74e-2)" "unprognostic (2.52e-1)" "unprognostic (2.26e-3)" 16.5 31.2 3.8 10.0 5.5 6.1 14.2 1.2 4.9 12.1 13.5 3.2 10.5 6.0 12.4 14.9 13.3 14.5 14.7 10.0 2.5 1.6 21.4 96.1 14.2 13.1 4.5 2.7 21.3 23.8 5.2 15.7 4.2 6.4 16.5 7.2 11.3 16.9 11.5 11.1 7.8 9.5 15.4 9.3 12.7 11.1 7.2 4.7 2.8 14.4 8.1 7.0 15.5 16.4 2.2 1.7 11.7 2.5 0.6 1.4 0.9 2.2 5.9 0.6 5.9 18.4 31.6 4.2 3.7 17.2 3.6 11.3 3.8 10.3 0.9 3.2 2.9 5.0 1.6 6.4 1.5 9.3 0.3 3.5 5.9 8.8 14.9 0.7 17.2 35.0 12.0 2.3 7.4 3.9 2.8 2.2 2.3 0.1 0.5 0.7 1.1 0.1 2.0 0.0 0.7 10.5 10.0 0.4 1.3 12.6 1.5 2.2 1.5 3.1 3.3 3.4 6.3 3.9 0.6 1.7 0.7 0.1 6.4 2.5 1.5 7.2 1.5 8.0 1.4 2.3 0.6 2.2 1.4 1.0 1.7 1.1 0.9 0.8 11.7 0.6 2.5 0.9 0.8 0.9 3.8 5.5 1.2 4.9 2.5 1.6 4.5 2.7 6.4 4.7 C1S ENSG00000182326 "Complement C1s" P09871 12 6988259-7071032 "Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Complement pathway, Immunity, Innate immunity" "Hydrolase, Protease, Serine protease" "Disease mutation, Ehlers-Danlos syndrome, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "liver: 351.6" "Cell line enhanced" "Detected in some" "ASC diff: 97.0;ASC TERT1: 129.2;BJ hTERT+: 41.1;HSkMC: 68.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Cell type enriched" "Detected in single" 10 "neutrophil: 6.2" "Lineage enriched" "Detected in single" 17 "granulocytes: 6.2" "Low region specificity" "Detected in all" "CAB016722, HPA018852" Supported Approved Nucleoplasm,Cytosol "Secreted to blood" 93000000000 13000000000 Nucleoplasm Cytosol "CAB016722: , HPA018852: AB_1847112" "unprognostic (2.72e-3)" "unprognostic (7.31e-2)" "unprognostic (9.37e-2)" "unprognostic (1.39e-2)" "unprognostic (1.05e-2)" "unprognostic (9.63e-2)" "prognostic favourable (7.73e-4)" "unprognostic (6.38e-2)" "unprognostic (1.16e-1)" "unprognostic (6.14e-2)" "unprognostic (1.57e-1)" "unprognostic (1.85e-2)" "prognostic unfavourable (7.44e-15)" "unprognostic (2.02e-2)" "unprognostic (5.68e-3)" "unprognostic (1.19e-2)" "unprognostic (5.39e-2)" 48.7 16.6 3.3 18.7 4.1 0.0 55.7 1.9 3.1 35.3 31.1 2.9 12.7 6.8 32.2 50.0 38.3 46.4 47.2 34.4 2.5 1.1 18.0 351.6 31.4 21.1 6.3 3.2 98.8 15.5 1.9 6.0 8.5 6.5 52.1 18.6 26.1 14.6 12.4 18.2 14.7 19.2 47.6 8.8 32.5 24.6 37.2 2.3 3.2 30.5 22.7 18.8 48.6 73.0 0.2 0.1 6.2 0.3 0.2 0.1 0.0 0.0 2.2 0.1 1.2 97.0 129.2 0.4 17.5 41.1 9.3 17.0 0.0 0.2 0.0 2.4 21.7 0.1 0.0 0.2 0.8 0.0 0.0 0.0 0.6 4.6 29.2 0.2 0.1 68.6 0.3 7.5 0.5 0.0 0.0 0.0 1.1 0.0 0.0 0.1 1.2 0.0 0.0 0.1 0.1 0.3 0.3 0.0 0.1 10.6 0.2 0.2 0.0 0.0 0.0 4.3 0.3 16.5 0.0 0.0 0.0 0.1 9.3 0.1 0.2 0.6 0.3 0.2 0.0 0.1 0.0 0.2 0.0 0.1 0.0 0.2 0.1 0.1 6.2 0.2 0.1 0.1 0.0 0.0 3.3 4.1 1.9 3.1 2.5 1.1 6.3 3.2 6.5 2.3 C2 ENSG00000166278 "Complement C2" P06681 6 31897785-31945672 "Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins" "Complement pathway, Immunity, Innate immunity" "Hydrolase, Protease, Serine protease" "Age-related macular degeneration, Disease mutation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 7 "liver: 132.7" "Group enriched" "Detected in some" 5 "Hep G2: 16.9;Karpas-707: 52.8" "Cancer enriched" "Detected in all" 9 "liver cancer: 100.2" "Low region specificity" "Detected in many" "Group enriched" "Detected in some" 7 "classical monocyte: 2.9;intermediate monocyte: 6.4;non-classical monocyte: 6.5" "Lineage enriched" "Detected in single" 8 "monocytes: 6.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in single" CAB016775 Supported "Secreted to blood" 52000000000 "CAB016775: " "unprognostic (2.05e-1)" "unprognostic (1.22e-1)" "unprognostic (7.68e-2)" "unprognostic (1.49e-3)" "unprognostic (7.40e-2)" "unprognostic (3.34e-2)" "unprognostic (1.36e-2)" "unprognostic (8.88e-3)" "unprognostic (3.02e-1)" "unprognostic (2.59e-3)" "unprognostic (3.27e-2)" "unprognostic (3.15e-3)" "prognostic unfavourable (2.64e-7)" "unprognostic (2.05e-1)" "unprognostic (4.42e-2)" "unprognostic (7.37e-2)" "unprognostic (2.55e-2)" 9.2 3.2 0.9 4.8 1.5 0.8 5.0 1.2 1.3 2.0 5.3 1.8 1.6 2.5 2.0 4.8 1.9 3.3 3.2 5.4 0.8 0.8 13.1 132.7 19.4 13.1 1.2 0.3 2.7 2.1 0.8 2.8 7.6 1.7 1.8 4.3 2.9 2.4 1.5 0.7 1.6 6.6 3.5 1.8 12.1 1.9 2.0 1.0 1.8 1.2 0.8 3.4 2.7 1.5 0.2 0.5 0.8 6.5 0.1 0.3 1.2 0.1 0.0 0.0 0.2 0.0 0.0 0.7 0.2 0.1 0.1 0.1 0.1 0.1 0.2 0.6 0.3 0.2 0.0 0.0 0.1 0.1 0.1 0.1 0.1 16.9 0.3 0.0 0.2 0.9 0.1 0.2 0.0 0.0 0.1 52.8 0.0 0.0 0.1 0.2 0.1 0.0 0.0 1.3 0.6 0.0 0.0 0.1 0.1 1.0 0.1 0.0 0.1 2.3 0.1 0.1 0.2 0.2 0.0 0.2 6.6 1.0 0.2 0.3 0.0 0.1 2.9 0.0 0.1 6.4 0.1 0.1 0.1 0.1 0.5 0.2 0.3 0.2 0.8 0.1 6.5 0.0 0.1 1.2 0.9 1.5 1.2 1.2 0.8 0.8 1.2 0.3 1.7 1.0 C9orf3 "AOPEP, AP-O, APO, C90RF3, FLJ14675" ENSG00000148120 "Chromosome 9 open reading frame 3" Q8N6M6 9 94726701-95087218 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Aminopeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell line enhanced" "Detected in many" "A549: 20.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA004633, HPA072729" Approved Approved "Cell Junctions" "Cell Junctions" "HPA004633: AB_1078362, HPA072729: " "unprognostic (4.25e-2)" "unprognostic (1.07e-3)" "unprognostic (6.29e-2)" "unprognostic (1.71e-1)" "unprognostic (1.12e-1)" "unprognostic (2.75e-2)" "unprognostic (9.59e-2)" "unprognostic (4.24e-2)" "unprognostic (2.99e-2)" "unprognostic (1.34e-1)" "unprognostic (2.60e-2)" "unprognostic (2.80e-1)" "prognostic favourable (6.33e-5)" "unprognostic (2.31e-1)" "unprognostic (2.56e-1)" "unprognostic (3.29e-2)" "unprognostic (3.37e-2)" 6.2 8.5 6.8 9.1 12.7 2.4 11.3 10.5 10.3 14.0 17.8 24.6 24.1 5.1 28.8 15.0 20.2 16.0 17.9 29.9 8.9 5.9 12.7 28.1 10.9 3.1 11.3 6.1 11.7 24.7 25.0 11.1 24.4 11.3 22.1 6.8 11.4 13.1 17.6 29.8 39.1 8.1 32.2 11.6 6.8 10.8 6.4 11.4 3.3 11.6 23.7 7.8 12.9 25.1 5.4 5.8 2.1 3.6 3.4 3.6 1.8 4.5 20.4 2.2 3.8 2.3 3.0 8.7 4.4 2.0 4.6 2.8 4.3 6.0 1.3 3.7 7.4 18.0 4.1 4.2 2.3 9.5 3.2 1.3 18.5 3.8 4.7 1.2 1.0 3.1 17.5 4.0 2.7 2.6 2.1 1.9 8.4 6.7 1.7 1.4 2.9 8.5 2.7 7.1 1.7 8.1 4.1 4.5 6.8 7.4 6.9 1.6 7.6 0.9 2.0 2.0 2.0 8.3 2.3 1.6 2.1 0.7 6.9 1.0 3.6 0.3 3.6 2.1 3.6 2.5 2.3 2.4 3.0 3.3 5.8 5.4 2.3 2.7 1.3 3.4 1.7 5.2 1.9 1.8 6.8 12.7 10.5 10.3 8.9 5.9 11.3 6.1 11.3 11.4 CAPN1 "CANP, CANPL1, muCANP, muCL" ENSG00000014216 "Calpain 1" P07384 11 65180566-65212006 "Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Disease mutation, Hereditary spastic paraplegia, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell line enhanced" "Detected in all" "RT4: 88.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA005992 Enhanced Supported Cytosol 28000000 Cytosol "HPA005992: AB_1845924" "unprognostic (2.07e-1)" "unprognostic (2.15e-1)" "unprognostic (2.69e-1)" "unprognostic (1.40e-1)" "unprognostic (4.06e-2)" "unprognostic (1.10e-1)" "unprognostic (1.91e-2)" "unprognostic (2.48e-2)" "unprognostic (7.23e-2)" "unprognostic (2.23e-2)" "prognostic unfavourable (4.30e-4)" "unprognostic (3.33e-1)" "prognostic favourable (7.06e-8)" "unprognostic (5.70e-3)" "unprognostic (1.51e-1)" "unprognostic (1.86e-1)" "unprognostic (2.98e-1)" 22.0 15.6 9.6 23.8 11.6 18.2 18.8 17.7 20.1 25.8 33.3 8.4 23.0 25.4 19.3 30.2 86.9 28.1 39.1 21.4 8.8 11.2 27.8 21.3 19.4 19.5 10.8 9.7 21.4 24.9 13.3 14.1 38.1 16.8 27.3 17.0 15.8 39.7 24.3 24.2 38.9 49.9 16.5 7.7 21.3 20.7 8.3 6.7 32.1 37.5 50.2 53.7 33.7 35.2 16.7 22.8 34.5 24.8 15.7 19.6 28.5 47.4 25.3 7.2 16.1 13.2 16.7 22.0 14.1 22.5 16.6 12.7 16.1 42.7 11.9 23.6 26.8 70.2 9.4 59.6 5.3 12.6 7.5 28.3 14.6 15.7 13.1 6.6 39.8 18.4 32.1 14.1 6.9 28.5 16.8 9.6 13.6 30.5 13.1 21.0 20.9 22.9 13.0 7.4 7.2 22.6 88.3 13.0 9.6 14.9 57.7 13.6 24.8 13.1 24.7 13.0 8.9 27.6 6.3 5.9 4.3 14.1 22.6 8.1 14.0 34.3 24.8 34.5 19.6 23.7 15.7 15.6 15.5 17.7 22.8 16.7 9.1 12.5 15.8 15.7 14.0 17.9 16.6 28.5 9.6 11.6 17.7 20.1 8.8 11.2 10.8 9.7 16.8 6.7 CAPN10 ENSG00000142330 "Calpain 10" Q9HC96 2 240586716-240617705 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Diabetes mellitus" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA004170, HPA056098" Approved Approved Nucleoplasm,Cytosol Nucleoplasm Cytosol "HPA004170: AB_1078381, HPA056098: " "unprognostic (1.05e-1)" "unprognostic (1.13e-2)" "unprognostic (9.29e-3)" "unprognostic (6.09e-2)" "unprognostic (5.44e-3)" "prognostic favourable (8.47e-5)" "prognostic unfavourable (4.78e-6)" "unprognostic (7.48e-3)" "unprognostic (7.94e-2)" "unprognostic (1.31e-2)" "prognostic favourable (7.94e-5)" "unprognostic (1.46e-1)" "unprognostic (1.11e-2)" "unprognostic (1.19e-1)" "unprognostic (6.88e-2)" "unprognostic (5.76e-2)" "unprognostic (5.58e-3)" 9.2 11.8 16.8 12.9 15.1 10.9 6.6 20.5 15.7 8.3 13.6 12.8 10.0 20.8 11.3 8.0 9.7 9.8 10.2 11.5 15.9 10.7 14.2 9.3 8.4 15.3 11.2 18.1 10.0 13.0 8.6 13.2 7.3 11.1 10.6 12.2 12.4 14.6 10.7 6.5 19.5 16.2 8.3 8.1 21.0 15.0 10.7 13.7 15.1 9.3 5.6 13.2 8.3 7.0 1.5 2.0 7.7 1.8 5.8 2.2 0.8 5.1 7.8 7.7 6.0 3.0 2.5 13.4 6.6 2.8 4.4 4.3 5.7 12.4 3.9 2.3 2.3 8.8 1.9 4.4 2.3 14.9 13.6 7.2 12.9 10.0 4.9 4.6 10.2 2.2 3.1 4.6 1.9 3.3 8.0 4.9 1.8 4.5 10.3 17.7 11.5 5.5 9.8 5.4 8.3 6.9 6.2 19.4 15.2 4.2 6.0 8.3 3.0 5.7 5.7 7.6 6.5 6.1 7.9 12.2 2.7 7.0 7.2 8.5 7.1 1.7 1.8 3.3 2.0 1.0 0.5 1.5 1.3 2.0 0.8 1.5 1.2 1.8 7.7 5.8 1.1 2.0 2.2 0.8 16.8 15.1 20.5 15.7 15.9 10.7 11.2 18.1 11.1 13.7 CAPN11 ENSG00000137225 "Calpain 11" Q9UMQ6 6 44158811-44184402 "Enzymes, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 33 "testis: 63.7" "Group enriched" "Detected in some" 5 "NTERA-2: 4.3;TIME: 10.8" "Not detected" "Not detected" "Not detected" "Not detected" "Low cell type specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low region specificity" "Detected in some" "Not detected" "Not detected" "CAB018070, HPA030955" Enhanced "CAB018070: AB_2069481, HPA030955: " "unprognostic (2.20e-2)" "unprognostic (1.87e-1)" "unprognostic (1.64e-2)" "unprognostic (2.75e-1)" "unprognostic (6.22e-2)" "unprognostic (3.34e-2)" "unprognostic (3.99e-2)" "unprognostic (4.57e-2)" "unprognostic (1.29e-1)" "unprognostic (8.96e-2)" "unprognostic (1.01e-1)" "unprognostic (2.13e-1)" "unprognostic (3.62e-6)" "unprognostic (2.38e-2)" "unprognostic (3.51e-1)" "unprognostic (2.27e-2)" "unprognostic (8.89e-2)" 1.1 0.3 0.1 0.2 0.1 0.2 1.9 0.1 0.1 0.5 0.1 0.1 0.1 0.0 0.2 0.4 0.1 0.1 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.2 0.1 0.1 0.1 0.1 0.0 0.1 0.3 0.1 0.1 0.0 0.1 0.3 0.1 0.1 0.6 0.3 0.2 0.1 0.1 0.0 63.7 0.1 0.1 0.1 0.1 0.2 0.2 0.3 0.4 1.2 1.3 0.1 0.1 0.8 0.9 0.0 0.0 0.5 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.2 0.4 0.1 0.0 0.0 0.0 0.0 0.0 0.5 0.6 0.2 0.0 0.0 0.1 0.0 0.0 0.0 0.0 1.5 0.4 0.4 0.0 0.0 0.0 0.3 4.3 0.0 0.7 0.2 0.4 0.0 0.0 0.4 0.1 0.0 0.0 0.0 0.0 0.2 10.8 0.5 0.0 0.0 0.0 0.2 0.3 0.0 0.0 0.1 0.1 0.6 0.1 0.1 0.1 0.0 0.0 0.0 0.8 0.0 0.3 0.4 0.1 0.2 1.3 0.1 0.0 1.2 0.0 0.9 0.1 0.1 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.1 CAPN12 ENSG00000182472 "Calpain 12" Q6ZSI9 19 38730187-38769904 "Enzymes, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Tissue enhanced" "Detected in many" "blood: 24.5;gallbladder: 21.0;liver: 21.8;salivary gland: 34.3" "Cell line enriched" "Detected in some" 5 "HMC-1: 17.2" "Low cancer specificity" "Detected in many" "Region enhanced" "Detected in some" "pons and medulla: 2.4" "Group enriched" "Detected in many" 7 "basophil: 24.5;NK-cell: 12.7" "Group enriched" "Detected in many" 7 "granulocytes: 24.5;NK-cells: 12.7" "Low region specificity" "Detected in single" "Region enhanced" "Detected in some" "hippocampal formation: 3.6" HPA053322 Approved "Nucleoplasm,Focal adhesion sites" "Focal adhesion sites" Nucleoplasm "HPA053322: " "unprognostic (1.81e-1)" "unprognostic (4.48e-2)" "unprognostic (1.04e-2)" "unprognostic (1.08e-1)" "unprognostic (1.95e-2)" "unprognostic (2.81e-2)" "unprognostic (1.02e-1)" "unprognostic (6.01e-3)" "unprognostic (7.20e-2)" "unprognostic (2.45e-2)" "unprognostic (1.29e-1)" "unprognostic (4.01e-2)" "prognostic unfavourable (5.90e-6)" "unprognostic (7.04e-2)" "unprognostic (4.01e-2)" "unprognostic (3.00e-1)" "unprognostic (4.59e-2)" 0.6 0.4 0.2 4.7 0.2 0.2 0.7 0.2 0.3 4.2 4.1 0.1 5.6 1.2 1.1 1.0 1.2 3.6 21.0 0.7 1.0 0.4 7.1 21.8 2.0 1.8 0.2 0.1 0.4 5.0 0.2 0.7 0.5 2.4 2.2 0.7 0.4 34.3 3.0 0.3 4.5 1.9 0.5 0.4 4.9 1.6 0.6 0.1 0.4 0.4 1.6 5.2 1.5 1.0 1.7 0.0 24.5 0.0 12.7 2.6 0.7 0.2 1.8 0.1 0.0 0.3 0.1 2.2 0.1 0.0 0.0 0.1 3.2 0.1 0.7 0.1 0.0 1.3 0.0 0.7 0.0 0.1 0.0 0.3 0.7 0.9 0.0 0.0 17.2 0.8 2.5 0.3 0.0 0.0 0.4 0.5 0.3 0.3 0.0 0.0 0.4 0.0 0.0 0.0 0.2 1.8 0.0 0.1 0.0 0.1 0.4 0.1 0.1 1.4 0.0 0.0 0.1 0.0 0.4 0.9 0.7 0.0 0.1 0.0 0.6 24.5 0.0 1.8 2.6 0.0 2.5 1.5 0.7 1.3 0.0 1.7 0.0 0.6 0.4 12.7 0.0 0.0 0.5 0.7 0.2 0.2 0.2 0.3 1.0 0.4 0.2 0.1 2.4 0.1 CAPN13 FLJ23523 ENSG00000162949 "Calpain 13" Q6MZZ7 2 30722771-30820542 "Enzymes, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 67.3;pancreas: 20.4;stomach 1: 17.6" "Group enriched" "Detected in some" 5 "RT4: 8.8;SK-BR-3: 21.2" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "HPA029496, HPA029497, HPA030034" Uncertain Approved Nucleoplasm Nucleoplasm "HPA029496: , HPA029497: , HPA030034: " "unprognostic (7.42e-2)" "unprognostic (1.19e-1)" "unprognostic (7.01e-3)" "unprognostic (1.96e-1)" "unprognostic (8.56e-2)" "unprognostic (1.51e-1)" "unprognostic (1.68e-1)" "unprognostic (1.32e-3)" "unprognostic (2.17e-1)" "unprognostic (2.66e-2)" "unprognostic (1.11e-1)" "unprognostic (2.49e-1)" "unprognostic (1.96e-2)" "unprognostic (3.64e-1)" "unprognostic (3.32e-2)" "unprognostic (5.03e-2)" "unprognostic (4.28e-3)" 0.2 0.0 0.5 0.5 0.4 0.0 4.8 0.2 0.2 6.2 39.6 0.3 0.2 13.0 1.1 0.6 1.1 0.5 7.4 0.2 0.8 0.4 2.0 0.2 9.4 0.2 0.7 0.3 0.4 20.4 0.6 1.2 0.2 0.2 5.2 16.0 0.2 1.0 0.2 0.2 0.1 67.3 1.6 1.0 0.2 17.6 0.2 0.2 0.2 0.2 0.5 1.0 3.3 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.6 8.8 0.1 0.4 0.0 21.2 0.0 2.9 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.4 0.2 0.2 0.8 0.4 0.7 0.3 0.2 0.2 CAPN14 ENSG00000214711 "Calpain 14" A8MX76 2 31173056-31233858 "Enzymes, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 18 "esophagus: 92.6;lymphoid tissue: 25.0" "Cell line enriched" "Detected in some" 6 "U-266/70: 7.7" "Group enriched" "Detected in some" 7 "cervical cancer: 2.9;head and neck cancer: 2.3;lung cancer: 0.8;stomach cancer: 1.4;urothelial cancer: 0.6" "Not detected" "Not detected" "Cell type enhanced" "Detected in single" "memory B-cell: 1.3" "Lineage enhanced" "Detected in single" "B-cells: 1.3" "Not detected" "Not detected" "unprognostic (5.81e-3)" "unprognostic (1.20e-1)" "unprognostic (4.57e-2)" "unprognostic (1.88e-2)" "unprognostic (3.85e-2)" "unprognostic (3.30e-1)" "unprognostic (3.61e-2)" "unprognostic (4.67e-2)" "unprognostic (1.71e-1)" "unprognostic (3.14e-1)" "unprognostic (3.77e-1)" "unprognostic (1.60e-1)" "unprognostic (3.71e-4)" "unprognostic (8.42e-2)" "unprognostic (6.84e-2)" "unprognostic (1.91e-1)" "unprognostic (4.47e-4)" 0.1 0.1 0.2 0.0 0.3 0.0 0.2 0.5 0.3 1.1 0.1 0.0 0.0 0.0 0.4 0.0 92.6 0.1 0.0 0.2 0.2 0.3 0.1 0.4 0.2 0.0 0.2 0.0 0.2 0.3 0.0 0.2 0.1 0.0 0.2 0.0 0.0 0.3 0.0 0.2 0.1 0.1 0.0 0.1 0.0 0.2 0.1 0.0 0.0 0.2 3.2 25.0 0.2 0.4 1.3 0.0 0.0 0.1 0.0 0.5 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.1 0.0 0.1 0.0 0.1 0.1 0.0 0.5 0.1 0.4 0.2 1.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.3 0.0 0.2 0.0 0.2 0.0 0.9 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 7.7 0.4 0.1 0.1 0.0 1.1 0.0 0.0 0.0 0.5 0.0 0.0 1.3 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.2 0.2 0.3 0.5 0.3 0.2 0.3 0.2 0.0 0.0 0.0 CAPN15 SOLH ENSG00000103326 "Calpain 15" O75808 16 527717-554636 "Enzymes, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Cell type enriched" "Detected in many" 5 "neutrophil: 15.8" "Lineage enriched" "Detected in many" 6 "granulocytes: 15.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA011960 Uncertain Approved Nucleoplasm Nucleoplasm "HPA011960: AB_10610556" "unprognostic (4.11e-2)" "unprognostic (1.63e-1)" "unprognostic (1.14e-1)" "unprognostic (2.66e-1)" "unprognostic (7.18e-2)" "unprognostic (1.12e-2)" "unprognostic (1.54e-3)" "unprognostic (8.31e-3)" "unprognostic (1.32e-1)" "unprognostic (1.24e-1)" "unprognostic (1.86e-1)" "unprognostic (4.02e-2)" "unprognostic (2.53e-3)" "unprognostic (2.54e-3)" "unprognostic (5.91e-2)" "unprognostic (1.83e-1)" "unprognostic (9.23e-3)" 9.2 7.7 7.1 13.1 6.8 12.0 12.0 20.4 10.9 5.6 15.7 5.7 8.6 26.1 7.9 5.4 10.7 7.5 13.4 5.9 9.8 2.9 9.7 14.1 8.6 8.2 5.8 4.7 8.2 20.5 4.3 9.1 6.1 5.0 7.2 4.7 3.7 11.7 6.9 11.4 14.3 24.7 7.0 3.4 16.8 21.9 10.8 4.1 9.7 6.9 6.6 11.8 6.4 11.8 2.7 0.5 15.8 1.1 1.1 0.4 0.2 8.4 11.0 1.6 4.8 0.9 1.8 24.3 9.0 2.4 2.6 1.7 14.3 6.2 12.2 8.7 1.6 11.2 1.0 3.5 0.9 12.6 19.3 10.1 11.2 8.8 3.9 11.8 14.3 2.0 2.1 2.5 1.2 2.7 18.5 3.6 0.8 13.0 13.1 13.0 14.1 10.4 23.1 4.5 12.0 1.7 5.5 10.2 9.3 5.9 8.3 5.1 6.8 12.4 13.3 8.0 11.3 8.1 11.2 9.8 5.3 10.4 3.5 6.9 5.0 3.0 1.1 0.7 0.2 0.8 0.1 0.3 0.1 0.4 0.3 2.7 0.1 0.2 15.8 1.1 1.0 0.5 0.2 0.2 7.1 6.8 20.4 10.9 9.8 2.9 5.8 4.7 5.0 4.1 CAPN2 "CANPL2, CANPml, mCANP" ENSG00000162909 "Calpain 2" P17655 1 223701593-223776018 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA024470 Approved Approved Supported Cytosol 1500000 Cytosol "HPA024470: AB_1845925" "unprognostic (2.77e-2)" "unprognostic (1.27e-3)" "unprognostic (2.03e-1)" "unprognostic (3.39e-2)" "unprognostic (2.12e-1)" "unprognostic (3.32e-2)" "unprognostic (1.59e-1)" "unprognostic (1.10e-1)" "unprognostic (2.85e-1)" "unprognostic (1.96e-1)" "prognostic unfavourable (2.50e-4)" "unprognostic (1.21e-1)" "prognostic favourable (2.19e-4)" "unprognostic (1.61e-1)" "unprognostic (2.63e-1)" "unprognostic (2.62e-1)" "prognostic unfavourable (6.21e-4)" 56.2 41.0 23.8 20.7 22.2 11.1 61.1 26.1 20.9 40.3 44.8 18.3 23.3 14.5 29.1 44.5 56.3 40.1 58.9 33.0 26.5 13.1 41.6 13.3 58.6 18.2 27.4 18.2 32.4 26.8 53.7 12.7 26.4 23.8 27.2 44.4 16.5 62.5 31.9 48.1 16.5 22.7 35.7 32.3 15.9 48.2 17.2 24.7 5.0 29.9 39.7 35.9 28.3 38.8 9.0 41.6 1.7 29.1 6.0 28.7 28.2 45.7 29.3 9.4 6.3 31.4 43.6 9.0 43.3 62.9 31.5 17.9 23.2 36.8 0.0 14.3 48.0 28.6 10.1 68.4 29.3 11.7 10.5 0.8 15.0 2.9 28.2 2.4 1.5 23.3 22.2 49.0 26.2 62.4 13.1 12.2 92.6 0.9 0.1 2.1 5.2 38.3 3.8 30.7 0.7 54.3 2.7 2.0 10.9 22.3 60.9 13.5 9.2 11.0 95.9 29.5 24.5 25.4 55.5 3.6 6.9 0.1 73.9 5.1 32.4 1.7 29.1 1.7 28.7 19.5 24.5 9.0 20.0 27.7 41.6 3.6 6.4 17.4 1.5 6.0 17.5 1.9 19.9 28.2 23.8 22.2 26.1 20.9 26.5 13.1 27.4 18.2 23.8 24.7 CAPN3 "CANP3, LGMD2, LGMD2A, nCL-1, p94" ENSG00000092529 "Calpain 3" P20807 15 42359500-42412318 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Disease mutation, Limb-girdle muscular dystrophy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 65.6;skeletal muscle: 210.9" "Cell line enriched" "Detected in some" 23 "SK-MEL-30: 75.1" "Cancer enriched" "Detected in some" 10 "melanoma: 9.1" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA040052 Enhanced "HPA040052: " "unprognostic (1.06e-2)" "unprognostic (1.31e-1)" "unprognostic (4.00e-2)" "unprognostic (8.71e-2)" "unprognostic (1.53e-1)" "unprognostic (1.72e-2)" "unprognostic (2.11e-4)" "unprognostic (3.12e-3)" "unprognostic (2.82e-1)" "unprognostic (2.47e-1)" "unprognostic (2.37e-3)" "unprognostic (3.26e-2)" "unprognostic (3.91e-4)" "unprognostic (5.56e-3)" "unprognostic (2.43e-1)" "unprognostic (8.93e-3)" "unprognostic (1.38e-1)" 5.7 1.8 13.0 2.3 32.1 16.7 3.8 3.1 22.9 2.1 2.4 65.6 0.0 2.2 3.1 47.0 4.2 2.5 3.0 3.6 19.9 11.5 22.1 6.3 6.7 3.4 50.7 19.5 3.1 1.4 3.4 1.7 2.0 39.0 3.0 3.2 5.0 3.1 3.1 210.9 19.7 2.3 2.8 52.6 3.3 2.1 4.1 47.3 0.0 1.6 27.6 3.0 2.7 2.3 1.5 1.7 0.9 2.6 1.3 3.2 1.4 0.1 0.2 0.2 0.3 3.2 3.1 0.3 1.2 0.7 0.1 0.2 0.3 0.2 0.0 0.4 0.6 1.8 0.1 1.3 0.1 0.3 0.3 0.2 0.4 1.0 0.1 0.5 0.6 2.1 1.9 0.2 0.5 0.0 0.0 0.9 0.1 0.0 0.0 0.5 0.1 0.2 0.5 0.0 0.7 0.8 0.5 0.0 0.0 0.0 0.1 75.1 0.0 1.7 0.3 0.0 0.1 1.6 0.2 0.4 0.7 0.0 0.2 0.9 0.7 0.0 2.6 0.0 2.8 0.6 2.8 0.4 0.3 1.0 1.7 1.5 0.2 3.2 0.9 1.3 0.2 1.6 1.3 1.4 13.0 32.1 3.1 22.9 19.9 11.5 50.7 19.5 39.0 47.3 CAPN5 "ADNIV, HTRA3, nCL-3, VRNI" ENSG00000149260 "Calpain 5" O15484 11 77066932-77126155 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Disease mutation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "gallbladder: 49.5;intestine: 47.8" "Cell line enhanced" "Detected in many" "U-2197: 18.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Cell type enhanced" "Detected in some" "gdT-cell: 4.8" "Lineage enriched" "Detected in single" 5 "T-cells: 4.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB033237, HPA072319" Uncertain Approved Nucleoplasm,Cytosol Nucleoplasm Cytosol "CAB033237: AB_2069673, HPA072319: " "unprognostic (6.81e-3)" "unprognostic (1.31e-1)" "unprognostic (3.36e-2)" "prognostic unfavourable (2.16e-6)" "unprognostic (3.47e-3)" "unprognostic (1.34e-1)" "unprognostic (1.13e-1)" "unprognostic (5.30e-2)" "unprognostic (2.52e-1)" "unprognostic (2.21e-2)" "unprognostic (5.35e-3)" "unprognostic (4.64e-1)" "unprognostic (3.17e-3)" "unprognostic (8.58e-3)" "unprognostic (3.25e-1)" "unprognostic (2.31e-2)" "unprognostic (2.30e-3)" 3.9 7.1 5.6 19.5 5.4 1.5 3.9 6.3 10.8 7.4 34.1 6.0 4.8 32.7 6.3 8.3 18.3 6.6 49.5 4.4 5.4 4.6 8.7 26.8 2.8 1.2 3.7 7.0 15.4 3.2 0.7 3.3 2.6 10.2 9.3 27.9 7.4 4.7 7.5 1.8 1.9 47.8 9.3 4.1 2.2 29.3 22.0 2.3 0.6 3.1 4.6 7.3 9.8 6.3 0.2 0.7 0.0 0.9 0.0 4.8 2.1 0.4 6.7 4.5 4.4 17.0 16.4 0.4 6.8 11.8 7.0 5.1 3.9 2.0 0.2 4.9 11.7 0.3 1.8 0.5 3.0 0.4 0.4 1.3 0.2 0.4 4.2 0.1 0.4 8.1 0.7 11.2 2.7 8.1 0.1 0.1 12.9 9.4 1.1 0.2 3.8 5.3 1.0 15.2 0.2 2.3 8.5 0.3 8.1 1.6 1.3 3.0 1.0 0.0 16.7 13.6 8.0 18.7 0.8 0.4 0.9 0.0 7.0 0.2 3.1 0.0 0.7 0.0 4.8 0.9 0.4 0.0 0.5 1.6 0.7 0.2 2.4 2.5 0.0 0.0 0.2 0.3 0.0 2.1 5.6 5.4 6.3 10.8 5.4 4.6 3.7 7.0 10.2 2.3 CAPN6 "CalpM, CANPX, CAPNX" ENSG00000077274 "Calpain 6" Q9Y6Q1 X 111245103-111270523 "Cancer-related genes, Enzymes, Predicted intracellular proteins" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 5 "epididymis: 62.9;placenta: 173.5" "Cell line enhanced" "Detected in some" "HAP1: 3.5;HDLM-2: 11.0;NTERA-2: 17.3" "Cancer enhanced" "Detected in many" "endometrial cancer: 25.9" "Not detected" "Not detected" "Cell type enhanced" "Detected in some" "NK-cell: 1.2;plasmacytoid DC: 2.0" "Low lineage specificity" "Detected in many" "Low region specificity" "Detected in single" "Low region specificity" "Detected in all" HPA040259 Approved Vesicles Vesicles "HPA040259: " "unprognostic (1.27e-3)" "unprognostic (2.04e-1)" "unprognostic (2.69e-2)" "unprognostic (5.77e-3)" "unprognostic (2.07e-1)" "unprognostic (9.93e-2)" "unprognostic (8.39e-3)" "unprognostic (1.06e-1)" "unprognostic (2.08e-1)" "unprognostic (9.45e-3)" "unprognostic (5.12e-1)" "unprognostic (6.25e-2)" "unprognostic (7.67e-2)" "unprognostic (6.50e-2)" "unprognostic (5.02e-3)" "unprognostic (2.66e-1)" "unprognostic (6.30e-2)" 1.7 0.0 0.2 1.7 0.2 0.0 6.0 0.3 0.3 3.9 4.2 0.2 23.4 0.2 18.2 62.9 2.4 2.9 2.6 0.4 0.2 0.0 5.1 0.4 0.3 1.1 0.2 0.4 1.9 4.1 0.0 0.2 173.5 0.3 3.6 2.2 2.1 5.6 21.7 1.7 1.0 1.3 2.0 0.3 1.0 7.2 2.8 0.2 0.5 1.7 4.7 2.9 1.4 2.6 0.1 2.0 0.8 0.0 1.2 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 3.5 0.0 0.0 11.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 17.3 0.0 0.0 0.0 0.1 1.5 0.0 0.1 0.4 0.4 0.4 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.8 0.0 0.0 0.0 0.0 0.6 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 2.0 0.1 0.0 0.2 0.2 0.3 0.3 0.2 0.0 0.2 0.4 0.3 0.2 CAPN7 PalBH ENSG00000131375 "Calpain 7" Q9Y6W3 3 15206152-15252918 "Enzymes, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA046617 Uncertain "HPA046617: " "unprognostic (2.70e-2)" "unprognostic (2.79e-1)" "prognostic favourable (4.85e-5)" "unprognostic (1.85e-1)" "unprognostic (1.69e-2)" "unprognostic (1.41e-2)" "unprognostic (2.22e-3)" "unprognostic (2.72e-1)" "unprognostic (1.42e-1)" "unprognostic (2.76e-1)" "unprognostic (1.39e-1)" "unprognostic (5.29e-2)" "unprognostic (1.12e-3)" "unprognostic (3.24e-2)" "unprognostic (7.84e-2)" "unprognostic (5.66e-2)" "unprognostic (1.05e-2)" 16.3 15.0 9.7 12.8 13.4 10.5 18.9 21.7 13.7 18.6 15.5 11.1 14.3 11.8 17.6 15.9 13.4 16.7 10.4 13.8 9.2 8.9 14.8 17.6 17.9 20.0 11.4 8.4 20.6 15.9 20.4 29.0 14.7 11.7 14.7 11.7 15.9 15.9 12.7 33.7 14.9 14.5 19.5 14.1 12.1 15.2 12.1 12.3 19.3 22.6 11.1 14.5 17.7 14.5 6.6 5.1 8.7 7.0 5.8 10.0 5.0 8.5 11.3 9.4 5.9 16.6 12.9 32.2 11.1 12.8 13.8 10.5 8.0 6.1 14.8 7.8 12.5 6.0 13.9 14.2 12.0 14.1 10.9 18.5 15.9 10.5 12.4 14.8 9.4 8.9 20.8 17.9 8.9 9.8 17.8 15.6 13.3 12.4 10.5 6.2 9.0 11.0 6.1 15.7 10.2 10.3 15.7 7.6 9.9 18.1 9.8 12.3 17.3 15.6 8.7 12.5 9.5 16.1 12.9 10.8 21.6 7.5 11.4 10.9 10.8 6.3 5.4 8.7 6.4 4.4 10.0 6.6 7.0 5.2 5.1 5.9 9.6 8.8 3.2 5.8 7.0 4.3 5.1 5.0 9.7 13.4 21.7 13.7 9.2 8.9 11.4 8.4 11.7 12.3 CAPN8 nCL-2 ENSG00000203697 "Calpain 8" A6NHC0 1 223538007-223665734 "Enzymes, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "gallbladder: 32.0;stomach 1: 85.8" "Cell line enriched" "Detected in some" 9 "RT4: 41.1" "Cancer enhanced" "Detected in many" "pancreatic cancer: 28.8" "Not detected" "Not detected" "Cell type enhanced" "Detected in some" "naive CD8 T-cell: 1.4" "Low lineage specificity" "Detected in many" "Not detected" "Not detected" "Not detected" "Not detected" HPA073939 Approved "Nucleoplasm,Nuclear membrane,Vesicles" "Nucleoplasm, Nuclear membrane, Vesicles" "HPA073939: " "unprognostic (4.87e-3)" "unprognostic (2.58e-1)" "unprognostic (1.89e-1)" "unprognostic (2.06e-2)" "unprognostic (1.32e-2)" "unprognostic (1.49e-1)" "unprognostic (7.97e-3)" "unprognostic (1.19e-1)" "unprognostic (1.26e-1)" "unprognostic (8.08e-2)" "unprognostic (2.72e-3)" "unprognostic (3.55e-1)" "unprognostic (4.12e-6)" "unprognostic (6.95e-2)" "unprognostic (5.59e-2)" "unprognostic (3.83e-2)" "unprognostic (5.44e-3)" 0.2 0.0 0.5 10.3 0.3 0.0 7.5 0.2 0.3 1.0 7.9 0.6 0.2 2.2 0.3 3.3 0.6 0.4 32.0 0.2 0.2 0.1 2.5 0.2 13.0 0.2 0.2 0.2 0.2 8.0 0.0 0.2 0.8 0.2 4.6 9.9 0.2 4.6 0.3 0.3 1.5 4.0 3.2 0.2 0.2 85.8 0.4 0.2 0.3 0.2 1.5 1.2 15.1 3.9 0.4 0.0 1.1 0.0 0.0 1.4 1.5 0.8 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.4 0.0 2.4 0.0 0.0 0.0 4.4 0.0 1.9 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.1 0.0 0.2 0.0 0.1 0.0 0.0 0.1 0.0 0.5 0.1 0.0 0.2 2.1 0.0 0.0 0.0 0.9 41.1 0.6 0.0 0.0 1.4 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.4 0.9 0.7 0.0 0.0 0.1 1.4 1.1 0.0 0.0 0.0 0.0 1.5 0.5 0.3 0.2 0.3 0.2 0.1 0.2 0.2 0.2 0.2 CAPN9 "GC36, nCL-4" ENSG00000135773 "Calpain 9" O14815 1 230747384-230802003 "Enzymes, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "intestine: 17.6;lung: 19.8;stomach 1: 35.8" "Cell line enriched" "Detected in some" 7 "SCLC-21H: 18.3" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Cell type enriched" "Detected in single" 17 "naive CD4 T-cell: 1.6" "Lineage enriched" "Detected in single" 17 "T-cells: 1.6" "Not detected" "Not detected" "Not detected" "Not detected" "HPA020398, CAB033483" Enhanced "CAB033483: AB_1119945, HPA020398: " "unprognostic (2.64e-1)" "unprognostic (1.20e-1)" "unprognostic (2.60e-2)" "unprognostic (1.09e-1)" "unprognostic (2.20e-1)" "unprognostic (2.49e-2)" "unprognostic (3.36e-2)" "unprognostic (2.30e-2)" "unprognostic (4.61e-2)" "unprognostic (3.44e-2)" "unprognostic (9.10e-2)" "unprognostic (1.60e-1)" "unprognostic (5.97e-5)" "unprognostic (1.51e-1)" "unprognostic (2.08e-1)" "unprognostic (4.60e-2)" "unprognostic (2.16e-1)" 0.2 0.7 0.4 7.0 0.3 0.0 0.2 0.3 0.5 0.4 10.4 0.4 0.2 3.9 0.2 0.2 0.7 1.5 12.7 0.2 0.5 0.2 0.2 0.2 19.8 0.2 0.6 0.2 0.3 0.2 0.0 0.6 0.2 0.2 0.8 13.7 0.2 8.1 0.2 1.3 0.0 17.6 0.2 1.1 0.2 35.8 0.2 0.2 0.2 0.2 1.0 7.1 3.7 0.2 0.0 0.0 0.0 0.0 0.0 1.6 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.8 0.0 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.6 0.1 0.0 0.6 0.0 0.5 0.0 0.0 0.0 0.1 18.3 0.0 0.0 0.6 0.0 2.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.6 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.4 0.3 0.3 0.4 0.5 0.2 0.6 0.2 0.2 0.2 CASP1 "ICE, IL1BC" ENSG00000137752 "Caspase 1" P29466 11 105025443-105035250 "Cancer-related genes, Enzymes, Predicted intracellular proteins" Apoptosis "Hydrolase, Protease, Thiol protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "blood: 64.2;lymphoid tissue: 40.7" "Cell line enhanced" "Detected in many" "BJ hTERT+: 37.8;HBEC3-KT: 17.9;HHSteC: 20.3;U-937: 44.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Region enhanced" "Detected in many" "olfactory region: 22.8" "Low region specificity" "Detected in all" "CAB002685, HPA003056" Approved Supported Nucleoplasm,Cytosol Cytosol Nucleoplasm "CAB002685: , HPA003056: AB_1846037" "unprognostic (1.21e-3)" "unprognostic (3.02e-1)" "unprognostic (9.47e-3)" "unprognostic (1.43e-1)" "unprognostic (1.47e-1)" "unprognostic (1.21e-1)" "unprognostic (5.24e-2)" "unprognostic (1.97e-1)" "unprognostic (1.66e-1)" "unprognostic (6.67e-2)" "unprognostic (2.75e-2)" "unprognostic (1.35e-1)" "prognostic unfavourable (3.11e-4)" "unprognostic (9.03e-2)" "unprognostic (2.30e-2)" "unprognostic (3.18e-1)" "unprognostic (5.19e-2)" 7.4 3.9 6.6 15.1 17.0 8.2 6.9 3.5 7.0 4.1 12.8 2.2 2.9 34.0 3.0 4.2 10.6 4.3 7.3 4.9 9.3 3.0 6.4 5.8 20.5 16.2 16.7 2.6 4.4 3.4 0.2 3.7 8.7 13.3 6.1 13.9 3.7 7.0 3.2 1.6 9.9 37.2 5.2 17.4 40.7 5.6 1.5 11.0 4.1 3.7 5.6 9.0 9.7 13.2 7.3 39.6 40.5 64.2 11.1 34.3 31.2 0.4 0.1 0.0 1.8 2.0 4.2 0.3 1.9 37.8 4.8 13.2 0.0 0.2 6.1 0.7 2.1 2.7 0.0 17.9 1.1 4.0 0.0 0.3 0.2 0.4 20.3 7.1 0.0 7.2 12.7 3.9 10.4 2.0 0.0 0.0 1.1 0.0 0.2 9.9 0.0 0.1 5.9 0.1 4.8 0.1 2.9 0.1 0.1 5.6 0.3 8.3 0.4 16.4 2.4 4.4 0.2 0.4 0.5 0.0 1.7 0.0 2.7 44.7 0.9 12.3 42.8 23.2 25.4 64.2 34.3 7.3 18.1 22.0 39.6 6.0 9.9 16.4 40.5 11.1 64.0 1.4 22.2 31.2 6.6 17.0 3.5 7.0 9.3 3.0 16.7 2.6 13.3 11.0 CASP10 MCH4 ENSG00000003400 "Caspase 10" Q92851 2 201182881-201229406 "Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" Apoptosis "Hydrolase, Protease, Thiol protease" "Cancer-related genes, Disease mutation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "intestine: 42.4" "Cell line enhanced" "Detected in many" "HUVEC TERT2: 17.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB003780, HPA017059" Approved Approved "Golgi apparatus,Vesicles" "Golgi apparatus" Vesicles "CAB003780: AB_289592, HPA017059: AB_1846040" "unprognostic (4.01e-2)" "unprognostic (8.24e-2)" "unprognostic (4.80e-1)" "unprognostic (1.28e-3)" "unprognostic (4.74e-2)" "unprognostic (2.25e-1)" "prognostic unfavourable (8.54e-4)" "unprognostic (1.73e-2)" "unprognostic (1.48e-2)" "unprognostic (3.68e-2)" "unprognostic (1.91e-1)" "unprognostic (1.04e-1)" "prognostic unfavourable (6.05e-7)" "unprognostic (3.23e-2)" "unprognostic (2.19e-2)" "unprognostic (4.49e-2)" "unprognostic (1.38e-2)" 16.0 3.3 3.4 10.1 3.4 14.9 7.6 1.9 3.3 7.0 17.7 4.4 4.3 18.6 8.3 8.2 10.4 4.9 7.2 4.8 3.6 3.0 10.3 7.8 14.2 10.4 4.1 1.4 3.4 6.1 1.4 2.1 8.5 4.7 5.0 11.9 4.1 6.9 6.9 3.6 5.4 42.4 4.8 5.6 26.1 8.7 2.1 2.5 17.1 6.8 8.2 17.9 9.4 6.1 7.8 6.0 4.7 15.4 7.1 7.1 5.8 2.9 2.3 0.1 0.2 0.1 0.2 5.1 0.5 3.4 0.3 1.3 3.1 6.8 0.2 4.9 1.7 1.9 0.1 1.6 0.9 1.4 3.3 8.2 2.4 10.2 1.1 5.4 8.9 0.3 1.4 3.7 0.3 17.7 9.8 12.1 0.3 0.1 10.5 5.1 0.3 1.5 5.7 0.3 12.1 6.2 4.1 0.1 0.1 2.8 0.1 1.3 0.0 5.2 7.1 0.2 0.5 2.3 0.1 13.2 7.8 0.3 3.3 4.2 0.1 4.7 9.6 0.6 6.2 13.5 5.2 7.8 5.2 3.4 5.3 5.0 7.1 6.0 1.9 7.1 15.4 6.0 1.0 5.8 3.4 3.4 1.9 3.3 3.6 3.0 4.1 1.4 4.7 2.5 CASP14 "MGC119078, MGC119079, MICE" ENSG00000105141 "Caspase 14" P31944 19 15049384-15058293 "Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins" Differentiation "Hydrolase, Protease, Thiol protease" Ichthyosis "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 6 "skin 1: 109.4" "Cell line enriched" "Detected in some" 7 "hTCEpi: 32.4" "Cancer enhanced" "Detected in many" "cervical cancer: 62.8" "Not detected" "Not detected" "Cell type enhanced" "Detected in single" "neutrophil: 2.3" "Low lineage specificity" "Detected in single" "Not detected" "Not detected" "Low region specificity" "Detected in many" "CAB010059, HPA027062" Enhanced Approved Nucleoplasm,Mitochondria,Cytosol 2200000 "Nucleoplasm, Cytosol" Mitochondria "CAB010059: AB_626800, HPA027062: " "unprognostic (1.17e-2)" "unprognostic (6.44e-3)" "unprognostic (6.22e-2)" "unprognostic (2.77e-1)" "prognostic unfavourable (7.59e-4)" "unprognostic (9.42e-2)" "unprognostic (2.19e-2)" "prognostic unfavourable (5.96e-4)" "unprognostic (2.68e-1)" "unprognostic (4.30e-2)" "unprognostic (1.99e-1)" "unprognostic (1.97e-1)" 0.2 0.2 0.2 0.0 0.3 0.0 1.9 0.2 0.3 17.9 0.2 0.0 0.8 0.0 1.1 0.3 1.2 0.1 0.0 0.2 0.3 0.2 0.4 0.3 0.2 0.0 0.2 0.0 0.1 0.3 0.0 0.2 0.5 0.0 7.7 0.0 0.0 0.8 2.7 0.3 109.4 0.2 0.0 0.2 0.1 0.2 1.6 0.0 2.3 0.2 0.9 0.0 0.6 4.0 0.8 0.5 2.3 0.6 0.1 0.6 0.0 0.7 0.1 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 4.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 32.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.8 0.6 0.4 0.4 0.2 0.4 0.3 0.6 0.4 0.1 0.8 0.5 0.4 2.3 0.1 0.2 0.5 0.6 0.0 0.2 0.3 0.2 0.3 0.3 0.2 0.2 0.0 0.0 0.0 CASP2 "ICH1, MGC2181, NEDD2, PPP1R57" ENSG00000106144 "Caspase 2" P42575 7 143288215-143307696 "Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins" Apoptosis "Hydrolase, Protease, Thiol protease" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "lymphoid tissue: 45.7" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB012175, HPA050678" Approved Approved Nucleoplasm Nucleoplasm "CAB012175: , HPA050678: " "unprognostic (6.96e-2)" "prognostic favourable (7.38e-4)" "unprognostic (2.74e-2)" "unprognostic (7.51e-2)" "unprognostic (4.24e-2)" "unprognostic (2.39e-2)" "prognostic unfavourable (2.34e-4)" "unprognostic (1.74e-2)" "unprognostic (1.34e-2)" "prognostic favourable (2.89e-4)" "unprognostic (1.91e-2)" "unprognostic (1.64e-1)" "prognostic unfavourable (5.01e-6)" "unprognostic (2.66e-3)" "unprognostic (9.48e-2)" "unprognostic (1.19e-1)" "unprognostic (1.64e-1)" 10.5 6.5 6.6 10.7 6.7 26.8 10.2 9.6 10.9 9.6 8.5 9.0 8.2 8.2 10.8 7.8 14.1 8.4 5.7 6.1 5.7 4.1 7.3 5.8 9.8 15.8 6.9 6.1 8.7 8.1 12.1 6.6 11.3 7.3 7.6 10.2 10.1 11.6 5.8 4.3 14.2 14.0 7.4 6.3 18.6 7.5 8.6 6.9 45.7 8.9 8.0 23.0 7.4 10.2 18.5 11.8 33.2 17.7 13.4 21.4 7.6 10.7 10.1 11.4 20.2 6.4 7.6 6.1 11.1 5.0 10.2 11.2 10.1 12.3 20.5 10.5 7.0 10.6 11.4 8.7 13.6 17.9 8.8 12.1 16.0 6.9 3.4 23.6 15.2 5.2 7.2 12.3 4.4 8.7 10.1 13.1 10.8 10.6 41.0 24.9 14.3 10.3 30.2 5.9 12.5 6.0 9.2 12.5 14.1 22.0 9.6 7.0 10.5 9.0 9.7 9.0 6.3 16.2 11.0 10.9 10.7 23.8 10.2 28.1 16.4 33.2 10.8 9.3 14.9 11.9 14.6 15.8 20.6 15.4 9.8 18.5 15.4 17.8 12.3 13.4 17.7 11.8 21.4 7.6 6.6 6.7 9.6 10.9 5.7 4.1 6.9 6.1 7.3 6.9 CASP3 "apopain, CPP32, CPP32B, Yama" ENSG00000164305 "Caspase 3" P42574 4 184627696-184649509 "Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins" Apoptosis "Hydrolase, Protease, Thiol protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "blood: 76.7" "Cell line enhanced" "Detected in all" "Karpas-707: 72.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in all" 7 "basophil: 76.7;eosinophil: 62.8" "Lineage enriched" "Detected in all" 7 "granulocytes: 76.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB000091, HPA002643, CAB008381" Enhanced Supported Nucleoplasm,Mitochondria 310000 "Nucleoplasm, Mitochondria" "CAB000091: , CAB008381: AB_590737, HPA002643: AB_1846048" "unprognostic (1.38e-1)" "unprognostic (1.06e-1)" "unprognostic (2.21e-2)" "prognostic favourable (2.24e-4)" "unprognostic (2.29e-3)" "unprognostic (3.58e-2)" "unprognostic (9.57e-3)" "unprognostic (5.86e-2)" "unprognostic (3.56e-2)" "unprognostic (1.12e-2)" "unprognostic (1.70e-2)" "unprognostic (2.41e-1)" "prognostic unfavourable (2.30e-5)" "unprognostic (1.41e-2)" "unprognostic (5.74e-3)" "unprognostic (1.30e-1)" "unprognostic (4.05e-3)" 20.7 11.6 10.8 16.9 10.5 16.7 10.0 22.3 9.2 10.4 25.4 12.8 12.5 32.3 13.9 11.5 22.8 8.9 12.0 8.8 10.0 8.8 10.6 18.7 12.4 23.6 10.2 8.5 8.3 10.0 4.6 13.6 29.4 9.7 8.8 20.9 8.2 13.0 10.0 12.6 9.5 49.7 9.3 12.6 26.5 18.7 6.4 10.9 44.7 7.8 13.5 24.3 16.2 11.0 4.2 5.2 76.7 10.6 9.2 9.9 7.0 8.2 4.6 18.3 8.7 11.4 15.2 10.6 24.8 18.8 17.4 10.1 8.3 6.9 11.5 3.9 12.1 7.0 14.5 8.8 19.9 29.4 7.9 18.3 3.6 19.3 13.6 14.9 17.5 20.7 10.8 11.0 9.0 21.5 15.1 72.7 17.9 3.5 23.5 13.9 18.1 5.8 17.0 8.6 11.0 15.0 13.5 10.5 11.4 10.7 9.8 13.9 5.3 9.7 14.6 8.0 7.3 5.9 11.4 33.8 31.7 7.9 9.7 10.4 11.3 76.7 4.2 62.8 5.5 6.8 5.7 4.2 5.1 7.8 5.2 3.1 3.9 5.8 5.8 9.2 10.6 4.1 9.9 7.0 10.8 10.5 22.3 9.2 10.0 8.8 10.2 8.5 9.7 10.9 CASP4 "ICE(rel)II, ICH-2, TX" ENSG00000196954 "Caspase 4" P49662 11 104942866-104969436 "Cancer-related genes, Enzymes, Predicted intracellular proteins" "Immunity, Inflammatory response, Innate immunity, Necrosis" "Hydrolase, Protease, Thiol protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 4 "blood: 82.8" "Low cell line specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "HPA027588, CAB037167" Approved Approved "Plasma membrane,Cytosol" "Intracellular and membrane" Cytosol "Plasma membrane" "CAB037167: AB_258864, HPA027588: AB_10603781" "unprognostic (1.19e-2)" "unprognostic (3.73e-1)" "unprognostic (3.44e-1)" "unprognostic (1.99e-2)" "unprognostic (7.19e-3)" "unprognostic (2.63e-2)" "unprognostic (1.26e-2)" "unprognostic (1.56e-2)" "unprognostic (5.31e-2)" "unprognostic (2.71e-1)" "unprognostic (2.38e-3)" "unprognostic (8.39e-3)" "prognostic unfavourable (3.27e-11)" "unprognostic (6.75e-2)" "unprognostic (1.34e-1)" "unprognostic (1.79e-2)" "unprognostic (4.08e-3)" 10.6 6.3 0.5 9.7 0.5 6.1 9.4 0.0 0.0 4.7 3.5 8.9 3.5 5.9 14.1 5.8 7.3 4.9 0.5 0.5 6.7 16.5 14.0 10.5 1.0 7.5 16.8 0.0 3.0 10.7 5.8 4.0 11.2 1.9 1.6 10.4 8.8 4.3 2.0 19.0 8.2 0.2 4.2 11.3 8.2 8.0 20.5 29.3 82.8 43.2 29.6 35.7 46.8 6.3 2.1 0.0 2.8 13.7 31.2 5.3 11.0 21.5 17.7 24.8 5.3 29.0 3.3 23.7 14.2 10.6 0.0 19.0 16.9 3.7 0.1 8.6 1.6 13.8 33.6 8.6 4.2 28.3 28.5 21.1 29.5 30.7 0.2 0.0 13.5 0.6 5.0 10.2 0.0 6.3 3.8 4.1 2.9 14.8 10.1 0.1 0.0 10.1 7.2 10.0 2.9 12.6 15.9 18.7 6.5 16.4 7.7 0.0 0.0 0.0 9.5 19.7 13.0 14.9 39.1 7.0 31.5 43.2 34.6 20.5 24.2 30.1 29.3 20.0 14.8 22.0 82.8 29.6 33.5 4.9 35.7 46.8 CASP5 ICE(rel)III ENSG00000137757 "Caspase 5" P51878 11 104994235-105023168 "Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins" Apoptosis "Hydrolase, Protease, Thiol protease" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 7 "blood: 22.3;intestine: 31.0;lymphoid tissue: 12.3" "Cell line enriched" "Detected in some" 7 "HHSteC: 9.1" "Group enriched" "Detected in some" 7 "colorectal cancer: 3.9;stomach cancer: 1.3" "Low region specificity" "Detected in some" "Group enriched" "Detected in some" 13 "intermediate monocyte: 10.5;neutrophil: 7.8;non-classical monocyte: 22.3" "Group enriched" "Detected in many" 14 "granulocytes: 7.8;monocytes: 22.3" "unprognostic (4.30e-2)" "unprognostic (8.86e-2)" "unprognostic (1.07e-1)" "unprognostic (4.74e-2)" "unprognostic (1.66e-1)" "unprognostic (5.22e-2)" "unprognostic (9.90e-2)" "unprognostic (8.29e-3)" "unprognostic (1.47e-1)" "unprognostic (4.38e-3)" "unprognostic (7.39e-3)" "unprognostic (3.25e-1)" "unprognostic (1.82e-9)" "unprognostic (7.30e-2)" "unprognostic (2.67e-3)" "unprognostic (1.87e-1)" "unprognostic (1.50e-1)" 0.6 0.3 0.3 11.8 1.0 0.0 0.3 0.2 0.8 0.2 13.3 0.2 0.0 8.2 0.2 0.2 0.3 0.5 0.1 0.4 2.9 0.3 0.4 1.2 2.7 10.5 0.4 0.2 0.2 0.3 0.0 0.9 0.5 2.0 0.4 11.3 0.2 0.3 0.0 0.8 0.2 31.0 1.4 2.1 12.3 0.4 0.3 0.3 0.3 0.3 0.3 0.1 0.9 0.3 0.0 1.0 7.8 22.3 0.0 0.1 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.2 0.0 0.8 0.0 0.6 0.2 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.1 0.0 9.1 0.0 0.0 0.3 1.2 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 1.0 0.0 0.0 10.5 0.1 0.0 0.0 0.0 1.0 0.0 0.0 0.0 7.8 0.0 22.3 0.3 0.0 0.6 0.3 1.0 0.2 0.8 2.9 0.3 0.4 0.2 2.0 0.3 CASP6 MCH2 ENSG00000138794 "Caspase 6" P55212 4 109688622-109703583 "Cancer-related genes, Enzymes, Predicted intracellular proteins" Apoptosis "Hydrolase, Protease, Thiol protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "intestine: 42.8" "Cell line enhanced" "Detected in all" "Karpas-707: 38.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB003775, HPA011337, HPA024303" Enhanced Supported Nucleoplasm,Cytosol Cytosol Nucleoplasm "CAB003775: AB_562064, HPA011337: AB_1846053, HPA024303: AB_1846052" "unprognostic (1.07e-1)" "unprognostic (1.91e-1)" "prognostic favourable (2.64e-5)" "unprognostic (1.45e-2)" "unprognostic (1.90e-1)" "unprognostic (1.46e-1)" "unprognostic (3.03e-3)" "unprognostic (9.87e-2)" "unprognostic (2.73e-2)" "unprognostic (2.59e-3)" "unprognostic (1.15e-2)" "unprognostic (6.78e-2)" "unprognostic (2.44e-1)" "unprognostic (8.74e-3)" "unprognostic (2.18e-1)" "unprognostic (2.41e-1)" "prognostic favourable (9.93e-4)" 8.1 6.1 3.6 6.7 4.3 5.3 14.3 2.8 3.8 6.9 25.5 2.8 4.5 23.4 5.9 4.3 8.7 5.3 11.7 4.9 4.0 2.0 11.0 14.3 5.6 8.5 5.0 1.6 7.0 13.0 2.3 6.4 4.3 4.5 8.1 19.5 3.4 8.0 10.3 3.4 6.5 42.8 14.0 6.6 9.1 9.2 2.7 4.3 14.5 11.2 3.3 8.4 8.2 12.7 4.4 8.0 8.5 7.0 5.6 21.3 8.0 12.4 4.0 8.3 7.5 6.1 6.0 12.3 7.0 4.8 6.2 6.8 6.7 25.6 1.3 8.1 7.1 5.8 9.9 11.0 5.0 19.7 6.5 10.9 3.6 5.9 4.9 10.9 7.7 6.6 8.2 6.0 1.5 11.8 14.1 38.8 10.1 7.0 28.1 6.9 6.3 7.3 9.8 5.3 6.8 20.6 11.8 8.8 6.6 7.4 13.3 4.1 5.7 4.0 10.0 6.9 7.4 3.3 7.9 5.7 10.3 1.4 9.0 13.1 3.5 8.5 5.3 6.3 4.9 4.8 5.3 4.1 17.8 9.3 6.0 4.4 21.3 11.8 1.1 5.6 7.0 8.0 16.4 8.0 3.6 4.3 2.8 3.8 4.0 2.0 5.0 1.6 4.5 4.3 CASP7 "CMH-1, ICE-LAP3, MCH3" ENSG00000165806 "Caspase 7" P55210 10 113679162-113730907 "Cancer-related genes, Enzymes, Predicted intracellular proteins" Apoptosis "Hydrolase, Protease, Thiol protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "intestine: 64.8" "Low cell line specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in many" "Low region specificity" "Detected in some" CAB025563 Approved "CAB025563: " "prognostic favourable (2.11e-4)" "unprognostic (3.18e-2)" "unprognostic (2.82e-2)" "unprognostic (2.18e-1)" "unprognostic (2.85e-1)" "unprognostic (1.33e-1)" "unprognostic (2.63e-3)" "unprognostic (3.96e-1)" "unprognostic (2.04e-1)" "unprognostic (1.22e-2)" "unprognostic (1.07e-1)" "unprognostic (2.35e-2)" "prognostic unfavourable (5.90e-4)" "unprognostic (5.45e-3)" "unprognostic (2.62e-1)" "unprognostic (2.86e-1)" "unprognostic (4.33e-3)" 16.5 7.8 8.6 12.3 8.7 3.4 22.1 4.7 11.3 13.3 35.5 5.9 9.8 30.8 12.6 6.1 12.0 9.5 7.8 9.0 7.6 3.9 14.1 15.7 16.2 12.2 7.3 2.7 11.0 18.4 5.7 9.6 10.2 9.1 11.9 28.5 5.8 21.8 10.5 9.7 10.9 64.8 9.3 12.4 12.3 21.0 4.3 8.0 12.0 8.4 8.1 11.3 10.6 36.6 9.6 8.6 14.6 17.1 5.4 12.2 7.4 10.8 11.7 9.6 5.1 17.6 15.5 6.7 12.6 19.7 22.5 28.3 8.7 18.8 11.5 7.5 11.4 9.6 11.8 9.5 16.0 17.8 15.9 7.4 8.7 14.5 11.8 7.9 9.8 10.0 6.4 12.8 5.3 29.7 1.9 15.7 8.3 14.6 18.7 6.2 1.7 7.2 19.1 39.1 6.9 17.8 8.0 0.7 5.7 9.7 14.1 6.6 16.7 7.0 14.2 5.0 9.6 5.2 10.3 11.6 7.3 0.3 5.1 14.9 5.6 14.6 12.5 9.4 9.6 17.1 8.4 9.6 8.3 12.2 8.6 7.3 6.5 8.7 2.1 5.4 14.0 1.1 11.1 7.4 8.6 8.7 4.7 11.3 7.6 3.9 7.3 2.7 9.1 8.0 CASP8 "Casp-8, FLICE, MACH, MCH5" ENSG00000064012 "Caspase 8" Q14790 2 201233443-201287711 "Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" "Apoptosis, Host-virus interaction" "Hydrolase, Protease, Thiol protease" "Cancer-related genes, Disease mutation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "blood: 52.5" "Low cell line specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA001302, CAB002047, HPA005688, HPA006191" Approved Supported Nucleoplasm,Cytosol Cytosol Nucleoplasm "CAB002047: AB_563465, HPA001302: AB_1846057, HPA005688: AB_1846056, HPA006191: " "unprognostic (5.21e-3)" "unprognostic (2.10e-1)" "unprognostic (1.83e-2)" "unprognostic (9.69e-3)" "unprognostic (2.09e-1)" "unprognostic (5.60e-2)" "prognostic unfavourable (3.02e-4)" "unprognostic (2.10e-1)" "unprognostic (4.79e-2)" "prognostic favourable (1.25e-4)" "unprognostic (7.75e-2)" "unprognostic (5.11e-2)" "prognostic unfavourable (1.27e-6)" "unprognostic (7.67e-3)" "unprognostic (2.43e-1)" "unprognostic (2.53e-1)" "unprognostic (4.53e-3)" 14.1 10.6 2.0 31.6 2.6 27.1 10.2 1.4 1.8 7.9 18.5 3.9 7.0 9.6 9.6 12.0 11.7 9.1 12.1 4.4 2.1 2.3 16.4 14.8 17.1 28.3 3.9 1.1 8.2 7.6 1.8 5.9 12.3 3.2 9.8 8.7 4.4 9.6 8.4 2.7 7.4 34.7 5.1 5.0 37.7 7.4 3.8 2.7 43.7 6.7 10.7 43.4 9.6 7.3 13.8 13.7 52.5 17.0 22.2 26.4 12.0 14.3 12.2 3.6 9.9 10.0 14.6 5.5 6.3 6.2 7.5 12.4 16.4 25.0 1.6 13.9 4.9 7.3 7.8 7.5 14.8 9.3 7.1 14.0 9.9 15.6 8.1 10.8 15.2 12.7 18.5 14.2 11.1 7.1 12.5 31.2 6.8 5.9 14.1 11.5 5.8 10.9 10.6 7.4 25.5 14.1 16.0 1.0 0.5 8.2 13.6 8.1 3.6 8.5 8.8 8.1 8.4 4.2 4.9 28.3 12.6 9.7 12.2 14.6 7.6 20.7 13.0 24.9 25.0 17.0 23.1 13.8 20.5 26.4 13.7 7.8 13.3 16.9 52.5 22.2 15.6 6.1 24.0 12.0 2.0 2.6 1.4 1.8 2.1 2.3 3.9 1.1 3.2 2.7 CASP9 "APAF-3, ICE-LAP6, MCH6, PPP1R56" ENSG00000132906 "Caspase 9" P55211 1 15490832-15526534 "Cancer-related genes, Enzymes, Predicted intracellular proteins" Apoptosis "Hydrolase, Protease, Thiol protease" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA001473, CAB004348, HPA046488" Approved Approved Mitochondria Mitochondria "CAB004348: AB_673489, HPA001473: AB_1078401, HPA046488: " "prognostic favourable (5.91e-4)" "unprognostic (2.42e-1)" "unprognostic (8.94e-3)" "unprognostic (7.84e-2)" "unprognostic (1.93e-2)" "unprognostic (8.54e-3)" "unprognostic (1.90e-3)" "unprognostic (6.75e-2)" "unprognostic (2.58e-1)" "unprognostic (1.29e-1)" "unprognostic (9.09e-2)" "unprognostic (1.98e-1)" "unprognostic (1.39e-2)" "unprognostic (2.35e-1)" "unprognostic (3.21e-2)" "unprognostic (5.48e-2)" "prognostic favourable (1.67e-5)" 7.4 24.1 7.8 8.2 9.3 8.9 5.5 11.1 8.7 8.3 9.3 10.2 18.9 5.2 11.9 16.5 7.5 13.4 29.1 10.2 8.3 7.2 11.6 9.4 10.8 12.6 10.7 4.3 33.4 29.0 15.6 18.5 14.7 8.8 10.2 6.4 8.7 6.6 19.0 8.2 2.8 13.3 7.8 9.0 11.0 6.7 14.4 7.1 6.2 14.8 7.2 14.6 7.3 8.1 11.2 11.7 23.3 11.2 13.0 5.1 6.1 7.1 10.4 4.1 7.1 9.3 4.6 3.7 5.2 6.9 7.8 10.0 7.3 8.6 10.4 12.3 7.1 2.5 6.8 5.5 9.0 3.6 8.5 7.4 23.2 7.3 8.7 7.2 8.7 6.3 10.2 11.9 3.6 8.3 16.7 9.7 4.6 3.6 2.4 8.2 4.0 5.8 4.8 10.2 12.1 9.6 4.1 3.5 6.8 7.4 1.8 12.3 4.4 5.2 3.3 10.4 4.8 11.2 3.4 9.4 14.1 11.7 7.9 7.8 3.4 22.7 11.2 23.3 5.1 8.2 3.7 9.6 3.0 3.6 11.7 11.2 1.7 2.6 16.0 13.0 7.9 5.2 2.8 6.1 7.8 9.3 11.1 8.7 8.3 7.2 10.7 4.3 8.8 7.1 CELA1 ELA1 ENSG00000139610 "Chymotrypsin like elastase family member 1" Q9UNI1 12 51328443-51346679 "Enzymes, Predicted intracellular proteins, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 8 "adrenal gland: 6.3;blood: 12.6;pancreas: 11.8" "Cell line enriched" "Detected in some" 4 "BEWO: 10.7" "Cancer enhanced" "Detected in single" "testis cancer: 0.5" "Cell type enhanced" "Detected in many" "basophil: 9.0;naive CD4 T-cell: 12.6" "Group enriched" "Detected in many" 7 "granulocytes: 9.0;T-cells: 12.6" "Low region specificity" "Detected in all" "Secreted - unknown location" "unprognostic (3.54e-2)" "unprognostic (1.64e-1)" "unprognostic (4.73e-2)" "unprognostic (2.73e-1)" "unprognostic (1.70e-1)" "unprognostic (1.52e-1)" "unprognostic (1.13e-1)" "unprognostic (3.59e-2)" "unprognostic (3.83e-3)" "unprognostic (2.52e-1)" "unprognostic (1.46e-1)" 0.0 6.3 0.0 0.2 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 1.2 0.1 0.0 11.8 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.1 1.0 0.0 0.6 0.0 0.3 0.0 0.0 0.3 0.9 9.0 1.6 0.2 12.6 1.3 0.0 0.0 0.0 0.0 0.0 0.0 10.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.2 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 2.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 9.0 1.6 0.1 1.1 0.8 0.4 0.3 2.7 0.8 0.9 0.0 12.6 5.9 0.2 0.2 0.9 0.0 0.3 1.3 CELA2A ELA2A ENSG00000142615 "Chymotrypsin like elastase family member 2A" P08217 1 15456728-15472091 "Enzymes, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 1559 "pancreas: 2376.3" "Cell line enhanced" "Detected in some" "HDLM-2: 1.1;HEL: 1.2;HL-60: 1.0;HMC-1: 4.9;K-562: 1.1;U-2 OS: 1.6" "Cancer enriched" "Detected in single" 3819 "pancreatic cancer: 463.9" "Not detected" "Not detected" "Cell type enriched" "Detected in single" 15 "neutrophil: 1.5" "Lineage enriched" "Detected in single" 15 "granulocytes: 1.5" "Secreted to digestive system" "unprognostic (9.78e-2)" "unprognostic (3.33e-2)" "unprognostic (5.60e-2)" "unprognostic (5.27e-2)" "unprognostic (3.63e-3)" "unprognostic (2.35e-1)" "unprognostic (4.14e-1)" "unprognostic (1.96e-2)" "unprognostic (1.38e-1)" "unprognostic (2.48e-1)" "unprognostic (3.94e-9)" "unprognostic (4.10e-2)" "unprognostic (3.42e-1)" "unprognostic (3.55e-2)" 0.2 0.1 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.0 0.1 0.2 0.1 0.0 0.1 0.1 0.1 0.1 0.1 0.1 0.8 2376.3 0.0 0.1 0.1 0.1 0.1 0.0 0.1 0.2 0.1 0.1 0.0 0.1 0.1 0.1 0.1 0.1 0.2 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.0 0.0 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 1.1 0.7 1.2 0.0 0.0 0.0 1.0 4.9 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.6 0.0 0.4 0.0 0.3 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.5 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.1 CELA2B "ELA2B, RP11-265F14.2" ENSG00000215704 "Chymotrypsin like elastase family member 2B" P08218 1 15465909-15491400 "Enzymes, Predicted intracellular proteins, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 188 "pancreas: 697.9" "Cell line enriched" "Detected in some" 5 "U-138 MG: 9.1" "Cancer enriched" "Detected in single" 574 "pancreatic cancer: 69.9" "Not detected" "Not detected" "Group enriched" "Detected in some" 5 "basophil: 3.7;neutrophil: 1.2" "Lineage enriched" "Detected in single" 7 "granulocytes: 3.7" "Secreted to digestive system" "unprognostic (4.36e-3)" "unprognostic (5.45e-2)" "unprognostic (6.66e-2)" "unprognostic (5.31e-3)" "unprognostic (4.47e-3)" "unprognostic (1.37e-3)" "unprognostic (4.66e-2)" "unprognostic (6.32e-2)" "unprognostic (2.73e-1)" "unprognostic (2.44e-1)" "unprognostic (2.94e-1)" "unprognostic (3.85e-2)" "unprognostic (1.22e-6)" "unprognostic (2.47e-1)" "unprognostic (6.67e-2)" "unprognostic (1.88e-1)" "unprognostic (7.80e-2)" 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 697.9 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 3.7 0.2 0.0 0.5 0.0 0.1 1.5 1.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.5 0.1 0.0 0.3 0.0 0.0 0.0 0.7 0.9 1.8 0.7 0.3 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.2 1.1 0.0 0.0 0.0 0.0 0.3 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.2 0.4 0.0 0.0 9.1 0.0 0.0 0.0 0.9 0.1 0.3 0.4 0.0 0.0 3.7 0.2 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 CELA3A "ELA3, ELA3A" ENSG00000142789 "Chymotrypsin like elastase family member 3A" P09093 1 22001656-22012539 "Enzymes, Predicted intracellular proteins, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 2051 "pancreas: 2541.2" "Cell line enriched" "Detected in single" 24 "MOLT-4: 21.1" "Cancer enriched" "Detected in some" 2497 "pancreatic cancer: 1481.6" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "HPA028086, HPA045650" Supported Approved Cytosol "Secreted to digestive system" Cytosol "HPA028086: , HPA045650: " "unprognostic (1.27e-1)" "unprognostic (2.71e-1)" "unprognostic (1.79e-1)" "unprognostic (6.32e-2)" "unprognostic (2.67e-1)" 0.2 0.0 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.0 0.1 0.3 0.1 0.0 0.1 0.1 0.1 0.1 0.1 0.1 1.2 2541.2 0.0 0.1 0.1 0.1 0.1 0.0 0.1 0.3 0.1 0.1 0.0 0.1 0.1 0.1 0.1 0.4 0.3 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.0 0.0 0.0 0.5 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.2 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 21.1 0.0 0.0 0.2 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.2 0.0 0.2 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.1 0.1 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.1 CELA3B "CBPP, ELA3B" ENSG00000219073 "Chymotrypsin like elastase family member 3B" P08861 1 21977021-21998642 "Enzymes, Predicted intracellular proteins, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 196 "pancreas: 1614.4" "Low cell line specificity" "Detected in many" "Cancer enriched" "Detected in single" 1218 "pancreatic cancer: 408.8" "Not detected" "Not detected" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "HPA028086, HPA045650" Supported Approved Cytosol "Secreted to digestive system" Cytosol "HPA028086: , HPA045650: " "unprognostic (2.89e-1)" "unprognostic (4.01e-3)" "unprognostic (6.53e-3)" "unprognostic (1.30e-1)" "unprognostic (1.29e-1)" "unprognostic (6.40e-2)" 0.1 0.0 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.1 0.1 0.1 0.6 1614.4 0.0 0.1 0.1 0.1 0.1 0.0 0.1 0.2 0.1 0.1 0.0 0.1 0.1 0.1 0.1 0.2 0.2 0.1 0.1 0.1 0.1 0.1 0.1 0.1 5.9 5.3 8.2 3.0 2.3 3.2 0.9 0.6 4.9 1.7 1.3 2.5 1.5 2.2 1.1 1.8 1.7 1.7 5.3 2.7 5.4 2.6 1.4 1.6 1.0 0.5 0.0 2.4 4.1 2.4 4.9 3.9 1.3 1.9 3.2 2.3 2.4 1.4 0.0 2.4 2.5 5.5 0.4 2.5 2.1 1.5 1.3 3.5 3.6 0.9 4.2 0.0 3.6 3.1 1.7 3.4 0.8 0.3 2.5 2.8 3.6 2.9 1.6 2.3 1.0 4.8 4.7 2.4 1.8 4.7 0.6 5.1 2.5 1.8 3.1 3.0 2.0 3.7 2.2 2.8 1.4 5.9 3.2 3.0 8.2 2.3 1.7 5.3 2.9 0.9 0.1 0.1 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.1 CFB "BF, BFD, H2-Bf" ENSG00000243649 "Complement factor B" P00751 6 31945650-31952084 "Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins" "Complement alternate pathway, Immunity, Innate immunity" "Hydrolase, Protease, Serine protease" "Age-related macular degeneration, Disease mutation, Hemolytic uremic syndrome" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 29 "liver: 461.5" "Cell line enhanced" "Detected in some" "ASC diff: 6.0;ASC TERT1: 5.8;CAPAN-2: 6.9;fHDF/TERT166: 11.3;HSkMC: 18.7" "Cancer enhanced" "Detected in all" "liver cancer: 78.3" "Low region specificity" "Detected in single" "Cell type enhanced" "Detected in single" "plasmacytoid DC: 1.6" "Low lineage specificity" "Detected in single" "HPA000951, HPA001817, HPA001832, CAB016381" Supported Approved "Endoplasmic reticulum,Vesicles,Cell Junctions" "Secreted to blood" 878700000 180000000000 "Endoplasmic reticulum, Vesicles" "Cell Junctions" "CAB016381: AB_627562, HPA000951: , HPA001817: AB_1078779, HPA001832: AB_1078778" "prognostic favourable (2.76e-5)" "unprognostic (1.02e-1)" "unprognostic (1.44e-1)" "unprognostic (7.94e-2)" "unprognostic (1.82e-2)" "unprognostic (8.56e-2)" "unprognostic (8.08e-3)" "unprognostic (8.81e-2)" "unprognostic (3.51e-1)" "unprognostic (2.26e-2)" "unprognostic (1.32e-2)" "unprognostic (6.57e-2)" "prognostic unfavourable (1.53e-5)" "unprognostic (1.36e-1)" "unprognostic (5.13e-2)" "unprognostic (1.05e-2)" "unprognostic (3.68e-2)" 9.3 1.0 0.3 4.1 0.4 0.3 2.4 0.2 0.4 1.3 9.0 0.4 0.9 3.2 0.5 3.7 2.2 4.0 8.9 3.3 0.2 0.0 16.1 461.5 2.5 2.1 0.7 0.1 2.8 5.8 0.4 1.0 4.0 1.0 4.0 1.6 2.6 3.1 0.3 0.5 0.5 4.7 2.6 0.6 0.8 4.1 1.4 0.3 0.3 1.8 0.5 1.7 1.6 0.4 0.1 1.6 0.0 0.8 0.0 0.2 0.0 0.0 1.8 0.1 0.1 6.0 5.8 0.0 0.0 0.3 1.5 0.6 0.0 6.9 0.1 5.1 11.3 0.0 0.0 1.9 1.4 0.4 0.3 0.4 0.3 0.5 0.0 0.7 0.1 18.7 0.1 0.9 0.6 0.2 0.2 0.7 0.1 0.1 0.1 0.4 0.3 0.1 0.2 0.4 0.2 1.6 0.0 0.0 0.0 0.5 1.2 0.2 0.0 0.2 0.0 0.2 0.5 0.3 0.3 0.5 1.9 0.5 3.1 0.5 0.5 0.0 0.8 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 1.6 0.0 0.0 0.3 0.4 0.2 0.3 0.2 0.0 0.7 0.1 1.0 0.3 CFD "ADN, DF, PFD" ENSG00000197766 "Complement factor D" P00746 19 859643-863630 "Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted secreted proteins" "Complement alternate pathway, Immunity, Innate immunity" "Hydrolase, Protease, Serine protease" "Disease mutation" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Group enriched" "Detected in some" 5 "ASC diff: 39.8;THP-1: 56.5" "Low cancer specificity" "Detected in all" "Not detected" "Not detected" "Cell type enhanced" "Detected in many" "basophil: 125.0" "Lineage enriched" "Detected in many" 5 "granulocytes: 125.0" "Not detected" "Not detected" "Low region specificity" "Detected in all" "Secreted to blood" 731723333 8000000000 "unprognostic (3.00e-2)" "unprognostic (6.09e-2)" "unprognostic (2.44e-1)" "unprognostic (1.22e-3)" "unprognostic (6.92e-2)" "unprognostic (5.28e-2)" "unprognostic (8.11e-3)" "unprognostic (2.48e-1)" "unprognostic (1.46e-2)" "unprognostic (8.10e-2)" "prognostic favourable (1.77e-4)" "unprognostic (9.53e-2)" "prognostic unfavourable (7.09e-4)" "unprognostic (1.23e-1)" "unprognostic (4.55e-2)" "unprognostic (1.92e-2)" "unprognostic (9.75e-2)" 161.3 4.6 0.0 16.4 0.0 5.6 96.7 0.0 1.7 44.2 35.2 0.2 42.2 10.9 8.9 89.8 54.1 15.6 59.0 102.0 0.0 0.0 1.9 2.3 34.0 6.2 0.0 0.0 13.7 6.0 1.7 0.1 20.2 0.1 102.0 4.3 3.4 22.7 15.1 40.5 35.8 16.5 97.3 0.1 3.7 19.7 33.6 0.0 0.8 52.6 55.6 9.0 83.7 130.3 0.6 5.6 125.0 25.8 0.1 1.0 10.4 0.7 1.9 0.0 0.3 39.8 6.2 2.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 1.5 0.0 0.5 0.2 0.0 0.0 1.1 2.8 0.0 1.7 0.6 0.6 0.3 1.0 6.3 0.0 0.0 0.0 0.0 2.3 0.1 0.0 0.9 0.0 8.9 0.1 2.8 0.2 0.0 0.9 0.0 0.1 0.3 0.3 0.8 0.2 0.0 1.1 56.5 0.0 0.0 0.9 0.4 0.1 1.7 0.7 0.0 0.0 3.3 0.0 125.0 18.2 58.8 0.7 20.1 1.0 0.6 0.5 0.9 5.6 0.2 0.7 0.8 43.2 0.1 25.8 0.5 0.3 10.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 CFI "C3b-INA, FI, IF, KAF" ENSG00000205403 "Complement factor I" P05156 4 109740694-109802179 "Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted secreted proteins" "Complement pathway, Host-virus interaction, Immunity, Innate immunity" "Hydrolase, Protease, Serine protease" "Age-related macular degeneration, Disease mutation, Hemolytic uremic syndrome" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 11 "kidney: 90.7;liver: 198.4" "Cell line enhanced" "Detected in some" "CAPAN-2: 28.9;Hep G2: 45.8;HSkMC: 19.0;RPTEC TERT1: 51.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Not detected" "Not detected" "Not detected" "Not detected" "HPA001143, CAB016777, HPA024061" Supported "Secreted to blood" 11000000000 "CAB016777: , HPA001143: AB_1078555, HPA024061: AB_1847129" "unprognostic (1.04e-1)" "unprognostic (5.79e-2)" "unprognostic (1.68e-1)" "unprognostic (6.32e-2)" "unprognostic (1.55e-2)" "unprognostic (8.58e-2)" "unprognostic (2.95e-2)" "unprognostic (3.00e-1)" "unprognostic (2.00e-2)" "unprognostic (5.42e-3)" "unprognostic (1.41e-1)" "unprognostic (3.61e-1)" "unprognostic (8.63e-2)" "unprognostic (1.29e-1)" "unprognostic (3.42e-2)" "unprognostic (1.74e-1)" "prognostic unfavourable (6.06e-4)" 9.5 13.2 1.5 2.3 1.4 0.0 3.9 0.9 2.5 5.0 4.1 1.1 2.9 4.9 5.0 12.0 4.4 9.7 9.3 6.2 1.6 0.8 90.7 198.4 7.2 3.1 1.8 0.7 10.6 7.6 0.5 3.8 3.2 2.6 3.9 0.7 6.8 3.6 3.6 1.4 0.5 4.6 3.0 3.0 7.8 1.7 3.6 1.6 0.5 5.3 2.3 1.4 3.8 3.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.6 0.7 0.0 0.0 0.0 28.9 0.0 9.2 0.0 0.0 0.0 0.0 0.0 9.7 0.3 0.0 0.1 45.8 2.0 0.0 0.0 19.0 0.0 0.0 0.0 1.9 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 51.2 0.1 0.0 0.1 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 5.6 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.5 1.4 0.9 2.5 1.6 0.8 1.8 0.7 2.6 1.6 CFLAR "c-FLIP, CASH, CASP8AP1, Casper, CLARP, FLAME, FLIP, I-FLICE, MRIT" ENSG00000003402 "CASP8 and FADD like apoptosis regulator" O15519 2 201116104-201176687 "Cancer-related genes, Enzymes, Predicted intracellular proteins" "Apoptosis, Host-virus interaction" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell line enhanced" "Detected in all" "U-266/70: 54.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Cell type enriched" "Detected in all" 5 "neutrophil: 79.2" "Lineage enriched" "Detected in all" 6 "granulocytes: 79.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA019044, CAB022157, CAB025216" Uncertain Supported "Nucleoplasm,Nuclear bodies,Plasma membrane,Cytosol" "Nucleoplasm, Plasma membrane, Cytosol" "Nuclear bodies" "CAB022157: , CAB025216: , HPA019044: AB_10696204" "unprognostic (4.61e-2)" "unprognostic (5.32e-2)" "unprognostic (2.49e-1)" "unprognostic (1.44e-1)" "unprognostic (2.95e-2)" "prognostic favourable (2.79e-4)" "unprognostic (7.46e-2)" "unprognostic (9.01e-2)" "unprognostic (1.76e-1)" "unprognostic (6.12e-2)" "unprognostic (3.08e-2)" "unprognostic (4.91e-2)" "unprognostic (2.90e-2)" "unprognostic (7.83e-2)" "unprognostic (9.13e-2)" "unprognostic (6.84e-2)" "unprognostic (2.24e-2)" 35.4 17.6 13.7 29.8 17.4 66.8 31.6 26.9 12.6 20.5 25.7 13.5 31.3 17.5 24.7 27.6 21.0 19.2 22.1 58.1 14.7 7.7 24.9 18.9 58.5 34.3 16.8 8.9 14.6 14.3 9.1 18.7 28.3 12.6 23.2 17.7 20.9 21.8 27.4 113.7 16.7 26.8 30.5 13.8 35.7 19.4 10.9 14.8 17.2 31.2 26.2 31.4 24.1 33.7 5.3 6.6 79.2 12.6 8.7 11.8 7.8 5.1 10.6 7.6 4.5 23.6 18.1 9.4 13.1 22.9 8.7 10.6 12.2 19.4 1.4 12.5 15.2 3.8 2.4 9.9 13.9 38.8 7.4 7.8 9.1 19.8 16.5 5.8 25.9 19.7 9.8 14.6 12.9 44.0 26.3 32.7 15.7 4.3 2.7 23.2 2.6 8.0 2.8 1.8 11.1 10.8 10.7 1.7 3.0 8.8 7.8 10.3 5.5 10.9 47.7 18.2 7.6 6.7 6.4 54.5 17.9 8.7 12.9 4.7 9.0 16.3 12.1 13.5 11.7 12.3 10.3 5.3 10.1 11.0 6.6 4.0 6.4 8.3 79.2 8.7 12.6 4.6 11.8 7.8 13.7 17.4 26.9 12.6 14.7 7.7 16.8 8.9 12.6 14.8 CLPP ENSG00000125656 "Caseinolytic mitochondrial matrix peptidase proteolytic subunit" Q16740 19 6361452-6368910 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" "Hydrolase, Protease, Serine protease" "Deafness, Disease mutation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA010649 Supported Supported Mitochondria Mitochondria "HPA010649: AB_1078538" "unprognostic (2.28e-1)" "unprognostic (7.14e-2)" "unprognostic (2.82e-1)" "unprognostic (4.34e-2)" "unprognostic (2.17e-2)" "unprognostic (1.15e-2)" "unprognostic (6.17e-3)" "unprognostic (7.43e-2)" "unprognostic (2.76e-1)" "unprognostic (1.31e-1)" "prognostic favourable (6.50e-4)" "unprognostic (1.21e-1)" "unprognostic (5.65e-2)" "unprognostic (6.97e-2)" "unprognostic (1.83e-1)" "unprognostic (1.03e-1)" "unprognostic (5.86e-3)" 22.1 27.3 18.4 22.5 18.8 20.1 19.9 16.6 20.9 16.1 23.2 17.9 22.2 25.4 16.9 15.1 26.6 15.3 19.2 28.9 17.4 16.7 28.5 64.7 15.5 35.5 19.0 15.2 23.7 32.7 11.6 18.5 18.4 13.6 19.1 14.1 18.6 26.3 23.4 73.1 17.8 26.0 14.8 16.7 21.2 21.3 21.1 11.4 54.8 27.0 25.1 25.3 20.7 23.2 29.7 37.5 14.9 20.0 27.6 46.3 32.9 31.6 21.1 15.4 28.1 9.7 13.5 16.0 18.8 13.8 26.8 24.0 16.9 11.6 31.9 29.3 15.0 19.8 15.2 23.7 10.1 33.1 47.9 23.5 18.6 25.0 26.3 21.2 31.1 17.1 17.4 18.6 20.8 26.0 23.2 43.2 17.5 37.0 36.3 22.2 22.2 49.4 25.6 18.6 48.3 19.9 17.7 25.5 24.4 11.9 29.1 27.6 15.0 30.4 18.1 17.7 16.4 41.6 35.4 55.6 46.4 30.7 24.3 29.9 28.1 5.5 20.0 10.5 28.0 17.7 33.2 28.3 39.9 34.5 24.1 29.7 35.2 34.1 14.9 27.6 12.1 37.5 46.3 32.9 18.4 18.8 16.6 20.9 17.4 16.7 19.0 15.2 13.6 11.4 CMA1 ENSG00000092009 "Chymase 1" P23946 14 24505353-24508265 "Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell line enhanced" "Detected in some" "AF22: 1.6;BEWO: 1.5;HL-60: 1.7;TIME: 1.5;U-937: 3.2" "Low cancer specificity" "Detected in some" "Not detected" "Not detected" "Cell type enriched" "Detected in single" 4 "T-reg: 1.5" "Lineage enriched" "Detected in single" 4 "T-cells: 1.5" "Low region specificity" "Detected in single" "CAB000363, HPA052634" Enhanced "Secreted to blood" 3000000 "CAB000363: AB_2083616, HPA052634: " "unprognostic (1.37e-1)" "unprognostic (2.27e-3)" "unprognostic (2.04e-1)" "unprognostic (7.07e-3)" "unprognostic (1.48e-2)" "unprognostic (1.19e-1)" "unprognostic (5.79e-2)" "unprognostic (2.21e-1)" "unprognostic (8.91e-3)" "unprognostic (4.19e-3)" "unprognostic (1.29e-4)" "unprognostic (2.52e-3)" "unprognostic (7.78e-2)" "unprognostic (7.37e-2)" "unprognostic (4.98e-3)" 12.3 0.2 0.2 2.9 0.2 0.0 15.9 0.2 0.2 7.3 6.2 0.2 1.2 0.1 2.9 6.0 8.3 1.0 10.0 10.3 0.2 0.2 2.0 0.8 1.1 1.6 0.2 0.2 0.6 0.9 0.5 0.5 0.7 0.3 6.0 6.9 3.0 5.9 1.3 1.2 13.0 5.3 6.2 0.2 0.5 2.4 2.7 0.2 1.0 0.4 7.9 3.9 4.1 2.0 0.3 0.0 0.0 0.0 0.0 1.5 0.5 0.0 0.0 1.6 0.0 0.0 0.0 1.5 0.3 0.0 0.0 0.0 0.0 0.4 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.8 0.0 1.7 0.7 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.8 0.4 0.9 1.1 1.1 0.0 0.0 0.5 0.5 0.0 0.0 0.0 0.8 0.0 0.8 1.5 0.0 0.3 0.3 0.3 0.9 1.0 0.3 0.0 3.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 1.5 0.5 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.3 0.2 CNDP1 "CN1, CPGL2, HsT2308, MGC10825" ENSG00000150656 "Carnosine dipeptidase 1" Q96KN2 18 74534440-74587212 "Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 9 "brain: 60.3;liver: 41.4" "Cell line enriched" "Detected in single" 69 "U-266/84: 41.2" "Group enriched" "Detected in some" 10 "glioma: 4.4;liver cancer: 1.0;melanoma: 1.3" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low region specificity" "Detected in single" "Low region specificity" "Detected in many" HPA008933 Enhanced "Secreted in brain" 1900000000 "HPA008933: AB_1847033" "unprognostic (7.43e-3)" "unprognostic (6.00e-2)" "unprognostic (8.55e-3)" "unprognostic (3.93e-1)" "unprognostic (1.32e-1)" "unprognostic (2.17e-2)" "unprognostic (8.04e-3)" "unprognostic (1.12e-2)" "unprognostic (2.81e-1)" "unprognostic (1.16e-1)" "unprognostic (1.16e-1)" "unprognostic (1.66e-1)" "unprognostic (6.90e-3)" "unprognostic (1.14e-1)" "unprognostic (3.30e-2)" "unprognostic (1.33e-1)" "unprognostic (1.28e-1)" 1.1 1.2 14.9 1.2 28.2 1.3 1.1 4.5 60.3 1.1 1.1 54.9 0.0 5.7 1.1 2.1 1.1 1.1 1.3 1.1 28.9 15.1 1.9 41.4 1.1 1.2 44.1 12.9 1.1 1.2 1.1 0.1 1.1 50.0 1.2 1.1 0.5 1.1 1.3 2.2 1.1 1.9 1.1 51.1 1.1 1.2 1.4 28.8 0.0 1.3 0.0 1.1 1.1 0.0 0.7 0.7 1.9 0.5 1.0 0.4 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.1 41.2 0.0 0.0 0.0 0.0 1.3 0.5 0.4 0.4 0.2 0.2 0.3 0.3 0.2 0.1 0.7 0.4 0.4 1.9 1.0 0.2 0.7 0.2 0.2 14.9 28.2 4.5 22.5 28.9 15.1 44.1 12.9 50.0 28.8 CNDP2 "CN2, CPGL, FLJ10830, HsT2298, PEPA" ENSG00000133313 "Carnosine dipeptidase 2" Q96KP4 18 74495816-74523454 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell line enhanced" "Detected in all" "Karpas-707: 75.1;RPMI-8226: 96.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB026196, HPA036898, HPA036899" Enhanced Enhanced Nucleoplasm,Cytosol 2400000 "Nucleoplasm, Cytosol" "CAB026196: , HPA036898: AB_2675370, HPA036899: AB_2675371" "unprognostic (2.81e-2)" "unprognostic (9.96e-2)" "unprognostic (3.28e-1)" "unprognostic (1.19e-3)" "unprognostic (2.57e-2)" "unprognostic (5.06e-2)" "unprognostic (2.84e-2)" "unprognostic (5.35e-2)" "unprognostic (1.49e-1)" "unprognostic (9.31e-2)" "unprognostic (1.56e-3)" "unprognostic (1.15e-1)" "prognostic favourable (3.50e-6)" "unprognostic (2.37e-3)" "unprognostic (4.65e-3)" "unprognostic (1.51e-1)" "unprognostic (1.34e-1)" 19.0 11.5 31.0 19.1 36.0 6.1 16.9 10.4 33.0 39.4 37.6 45.2 27.0 51.3 12.5 35.3 20.4 38.9 25.9 11.6 31.1 26.4 89.0 66.4 22.1 23.0 36.1 24.1 11.4 27.6 15.7 13.7 28.8 27.2 34.7 22.2 14.1 16.9 32.7 7.5 11.8 71.1 10.4 39.4 39.2 27.2 6.5 32.5 10.9 43.9 11.6 21.4 28.4 12.0 29.6 49.0 12.5 44.4 31.4 23.9 30.3 10.0 13.6 9.9 9.3 12.1 7.2 41.6 10.6 10.0 14.5 14.5 7.9 10.8 12.7 13.5 11.5 15.3 15.0 20.1 10.4 19.0 5.9 12.6 6.9 12.5 17.6 24.7 19.7 10.8 15.5 12.5 22.7 12.7 13.3 75.1 9.6 11.3 13.1 11.8 14.9 8.1 14.3 11.4 96.6 57.1 42.2 10.7 5.6 8.3 59.0 14.1 24.7 10.2 13.2 15.6 13.3 3.4 7.1 14.1 57.6 17.0 10.5 18.1 13.0 7.8 30.0 12.5 21.8 44.4 23.8 28.9 17.6 20.3 49.0 29.6 19.1 20.7 4.4 31.4 43.1 43.0 23.9 30.3 31.0 36.0 10.4 33.0 31.1 26.4 36.1 24.1 27.2 32.5 COPS5 "CSN5, JAB1, MOV-34, SGN5" ENSG00000121022 "COP9 signalosome subunit 5" Q92905 8 67043079-67083783 "Enzymes, Predicted intracellular proteins" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004242, HPA004845, HPA051531" Supported Enhanced Nucleoplasm 27000 Nucleoplasm "CAB004242: AB_627835, HPA004845: AB_1078557, HPA051531: " "unprognostic (1.90e-3)" "unprognostic (1.35e-1)" "unprognostic (1.61e-1)" "unprognostic (2.85e-3)" "unprognostic (2.53e-1)" "unprognostic (4.16e-2)" "unprognostic (2.04e-3)" "unprognostic (1.39e-1)" "unprognostic (2.15e-2)" "unprognostic (4.48e-2)" "unprognostic (4.74e-3)" "unprognostic (1.96e-2)" "unprognostic (1.90e-3)" "unprognostic (2.88e-2)" "unprognostic (1.76e-1)" "unprognostic (2.58e-1)" "unprognostic (1.18e-2)" 20.2 26.3 29.4 19.6 28.6 16.2 28.1 28.5 40.3 18.0 21.7 15.6 20.2 22.0 17.6 21.7 24.0 17.7 15.5 46.8 27.6 27.5 27.4 33.7 16.8 17.5 31.8 29.9 17.0 20.7 23.3 21.7 24.3 33.7 18.3 25.5 9.9 19.6 18.9 64.0 16.8 22.5 23.3 39.2 16.1 20.7 27.4 31.3 19.6 18.5 29.2 22.4 18.3 16.5 20.7 35.1 33.7 30.0 26.5 28.1 22.3 30.2 28.7 24.4 22.3 25.7 27.4 19.4 26.7 21.9 37.1 33.4 18.6 37.3 28.1 12.3 27.5 25.3 32.7 29.4 40.9 26.9 28.2 39.9 28.9 24.9 24.9 25.2 24.3 24.9 37.7 30.2 39.0 36.1 47.2 19.5 33.2 28.1 44.3 44.2 32.4 33.1 28.5 17.5 22.1 39.2 27.0 14.8 20.4 15.3 29.7 25.8 48.8 26.0 26.7 18.8 23.3 22.7 20.8 24.6 31.3 37.4 27.5 28.7 25.6 26.0 28.6 33.7 20.8 30.0 21.7 20.7 20.1 23.1 35.1 17.5 21.6 19.1 21.2 26.5 28.3 18.4 28.1 22.3 29.4 28.6 28.5 40.3 27.6 27.5 31.8 29.9 33.7 31.3 COPS6 "CSN6, MOV34-34KD" ENSG00000168090 "COP9 signalosome subunit 6" Q7L5N1 7 100088954-100092200 "Enzymes, Predicted intracellular proteins" "Host-virus interaction" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA044315 Approved Supported Nucleoplasm "Intracellular and membrane" 58000 Nucleoplasm "HPA044315: AB_10959750" "unprognostic (1.48e-2)" "unprognostic (2.43e-2)" "unprognostic (6.56e-3)" "unprognostic (1.38e-1)" "unprognostic (5.84e-2)" "unprognostic (2.09e-2)" "unprognostic (3.62e-3)" "unprognostic (2.93e-2)" "unprognostic (2.00e-1)" "unprognostic (2.45e-2)" "unprognostic (4.96e-2)" "unprognostic (1.25e-1)" "prognostic unfavourable (6.72e-4)" "unprognostic (1.20e-1)" "unprognostic (3.58e-2)" "unprognostic (8.57e-2)" "unprognostic (8.77e-2)" 25.4 30.0 37.7 20.2 50.6 19.7 25.6 31.5 43.3 32.5 30.4 26.5 15.1 19.3 31.0 39.8 33.4 33.7 32.4 47.2 31.5 32.1 31.7 41.2 20.1 30.4 33.3 32.6 30.8 42.8 38.1 28.2 29.1 34.1 27.4 26.6 25.0 28.3 35.7 53.1 23.4 19.2 45.2 30.1 22.7 26.9 25.5 30.8 29.4 27.6 21.6 25.8 26.7 24.8 53.4 67.6 58.9 64.0 48.2 69.4 45.3 31.8 45.4 27.3 32.3 24.0 28.7 17.3 29.0 44.6 48.6 35.7 37.1 30.2 22.1 37.5 47.4 24.4 30.8 49.0 49.2 21.9 48.3 18.8 45.1 28.6 50.3 21.3 19.5 28.3 32.5 52.2 55.9 66.3 26.9 31.9 57.1 79.3 47.1 31.7 24.6 54.6 22.5 45.4 52.6 38.5 30.0 42.8 31.8 29.9 59.2 21.9 24.4 21.1 34.8 46.8 42.7 56.0 50.9 23.6 26.1 45.2 35.4 29.0 69.0 58.9 61.9 51.7 61.1 64.0 61.2 53.4 61.3 57.8 67.6 49.8 48.3 53.9 24.1 48.2 57.4 50.2 69.4 45.3 37.7 50.6 31.5 43.3 31.5 32.1 33.3 32.6 34.1 30.8 CORIN "ATC2, CRN, Lrp4, PRSC, TMPRSS10" ENSG00000145244 "Corin, serine peptidase" Q9Y5Q5 4 47593998-47838106 "Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 5 "epididymis: 11.6;heart muscle: 39.5" "Cell line enriched" "Detected in some" 4 "ASC TERT1: 31.8" "Low cancer specificity" "Detected in some" "Region enriched" "Detected in single" 5 "pons and medulla: 1.6" "Not detected" "Not detected" "Not detected" "Not detected" "Region enhanced" "Detected in some" "basal ganglia: 2.7" "Low region specificity" "Detected in single" HPA070941 Approved "Nuclear bodies,Plasma membrane,Actin filaments" "Intracellular and membrane" "Plasma membrane" "Nuclear bodies, Actin filaments" "HPA070941: " "unprognostic (1.05e-1)" "unprognostic (2.52e-1)" "unprognostic (1.14e-1)" "unprognostic (1.93e-1)" "unprognostic (2.10e-1)" "unprognostic (3.18e-1)" "unprognostic (3.58e-4)" "unprognostic (3.19e-1)" "unprognostic (3.67e-2)" "unprognostic (8.22e-2)" "unprognostic (9.78e-2)" "unprognostic (6.53e-2)" "unprognostic (1.18e-1)" "unprognostic (2.86e-2)" "unprognostic (5.18e-2)" "unprognostic (7.22e-2)" "unprognostic (1.33e-2)" 0.3 0.1 0.3 0.0 0.1 0.0 0.8 0.1 0.1 3.1 0.1 0.1 2.6 0.0 3.4 11.6 0.7 1.2 4.5 39.5 0.0 0.2 2.0 0.0 1.3 0.0 0.2 0.0 0.6 0.1 0.0 1.5 0.6 1.6 1.7 0.0 0.4 0.3 4.6 0.2 5.3 0.4 0.5 0.0 3.5 0.3 3.7 0.0 0.2 0.1 1.7 0.4 0.8 3.2 0.2 0.0 0.5 0.5 0.0 0.3 0.0 0.0 0.0 0.0 0.2 7.3 31.8 0.0 1.3 2.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 1.5 0.1 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.6 1.0 0.0 0.2 0.1 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.5 0.3 0.0 0.1 0.0 0.0 0.2 0.0 0.0 0.5 0.0 0.1 0.0 0.0 0.0 0.3 0.1 0.1 0.1 0.0 0.2 0.2 0.0 1.6 0.0 CPA1 CPA ENSG00000091704 "Carboxypeptidase A1" P15085 7 130380339-130388114 "Enzymes, Predicted intracellular proteins, Predicted secreted proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 3231 "pancreas: 3541.6" "Cell line enriched" "Detected in some" 5 "AN3-CA: 15.8" "Cancer enriched" "Detected in some" 639 "pancreatic cancer: 1377.7" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in many" "HPA021836, CAB025197, HPA052215" Enhanced "Secreted to digestive system" 17000000 "CAB025197: , HPA021836: AB_1846005, HPA052215: " "unprognostic (8.41e-2)" "unprognostic (9.24e-4)" "unprognostic (5.22e-2)" "unprognostic (1.76e-1)" "unprognostic (3.97e-1)" "unprognostic (1.76e-1)" "unprognostic (2.27e-1)" "unprognostic (1.15e-2)" "unprognostic (1.35e-1)" "unprognostic (1.34e-6)" "unprognostic (4.99e-1)" "unprognostic (1.67e-1)" "unprognostic (2.16e-1)" "unprognostic (4.37e-2)" 0.3 0.0 0.1 0.1 0.1 0.0 0.1 0.1 0.2 0.1 0.1 0.1 0.1 0.2 0.1 0.1 0.1 0.0 0.1 0.3 0.1 0.0 0.1 0.1 0.1 0.1 0.1 0.1 1.0 3541.6 0.0 0.1 0.1 0.1 0.1 0.0 0.1 0.3 0.1 0.1 0.0 0.1 0.1 0.1 0.1 0.1 0.4 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 15.8 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 1.9 0.0 0.0 0.0 0.0 0.0 1.3 0.0 0.0 0.0 0.5 1.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 2.9 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.2 2.3 0.0 0.3 0.0 1.9 0.3 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.1 0.1 0.1 0.2 0.1 0.0 0.1 0.1 0.1 0.1 CPA2 ENSG00000158516 "Carboxypeptidase A2" P48052 7 130266827-130289798 "Enzymes, Predicted secreted proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 529 "pancreas: 1357.9" "Cell line enhanced" "Detected in some" "AN3-CA: 4.4;CACO-2: 7.3;RH-30: 6.1;SCLC-21H: 3.3" "Cancer enriched" "Detected in many" 60 "pancreatic cancer: 411.4" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in some" "Low region specificity" "Detected in many" "HPA020342, HPA021317" Enhanced Approved "Golgi apparatus" "Secreted to digestive system" 1500000 "Golgi apparatus" "HPA020342: AB_1846007, HPA021317: AB_1846008" "unprognostic (1.12e-1)" "unprognostic (3.97e-1)" "unprognostic (4.21e-2)" "unprognostic (1.82e-2)" "unprognostic (1.38e-1)" "unprognostic (6.76e-2)" "unprognostic (4.65e-2)" "unprognostic (1.08e-1)" "unprognostic (1.40e-1)" "unprognostic (1.84e-1)" "unprognostic (2.66e-1)" "unprognostic (3.84e-5)" "unprognostic (7.52e-2)" "unprognostic (1.42e-1)" "unprognostic (7.12e-2)" "unprognostic (8.48e-2)" 0.1 0.0 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.1 0.4 0.1 0.1 0.3 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.1 0.1 0.1 0.4 1357.9 0.0 0.1 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.1 0.0 1.0 0.1 0.2 0.1 2.5 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.9 4.4 0.0 0.1 0.0 0.0 0.0 0.7 0.0 7.3 0.0 0.0 1.0 0.0 0.0 1.4 0.0 0.1 1.0 0.0 0.0 0.8 0.0 0.1 0.0 0.0 0.1 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.9 0.4 0.0 6.1 0.1 0.1 0.6 3.3 0.0 0.2 0.0 2.0 0.0 0.2 0.0 0.0 1.1 0.8 0.6 0.0 0.7 0.2 0.8 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.1 CPA3 ENSG00000163751 "Carboxypeptidase A3" P15088 3 148865256-148897196 "Enzymes, Plasma proteins, Predicted secreted proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "blood: 111.7" "Cell line enriched" "Detected in some" 43 "HEL: 79.6" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Cell type enriched" "Detected in single" 1118 "basophil: 111.7" "Lineage enriched" "Detected in single" 1118 "granulocytes: 111.7" "Low region specificity" "Detected in single" "HPA006479, HPA008689, CAB020712" Enhanced Approved "Nucleoplasm,Golgi apparatus" "Secreted to blood" "Golgi apparatus" Nucleoplasm "CAB020712: , HPA006479: AB_1078396, HPA008689: AB_1846009" "unprognostic (1.07e-1)" "unprognostic (3.03e-2)" "unprognostic (2.66e-3)" "unprognostic (9.13e-3)" "unprognostic (3.50e-1)" "unprognostic (1.18e-3)" "unprognostic (2.47e-1)" "unprognostic (1.57e-2)" "unprognostic (2.14e-1)" "unprognostic (9.51e-2)" "unprognostic (1.89e-1)" "unprognostic (5.30e-3)" "unprognostic (3.50e-3)" "unprognostic (5.18e-3)" "unprognostic (3.24e-2)" "unprognostic (1.74e-1)" "unprognostic (1.69e-3)" 12.4 0.6 0.4 12.0 0.4 5.6 6.2 0.4 0.5 25.4 14.1 0.8 4.4 7.1 14.1 21.2 16.5 3.7 50.9 4.5 0.4 0.2 5.8 2.8 37.3 15.2 0.4 0.4 2.0 7.2 0.7 0.8 1.3 0.5 37.3 16.4 8.5 8.8 5.8 1.4 12.7 20.2 24.3 0.4 1.0 13.7 7.1 0.4 3.6 1.4 9.9 7.1 14.0 8.9 0.0 0.0 111.7 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 79.6 0.0 0.0 0.0 0.0 1.8 0.0 0.0 0.0 0.1 1.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 111.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.4 0.4 0.4 0.5 0.4 0.2 0.4 0.4 0.5 0.4 CPA4 CPA3 ENSG00000128510 "Carboxypeptidase A4" Q9UI42 7 130293134-130324180 "Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "esophagus: 18.0;skin 1: 41.0" "Cell line enhanced" "Detected in many" "BJ hTERT+: 30.8;LHCN-M2: 62.5;U-2 OS: 34.2;U-87 MG: 61.4" "Cancer enhanced" "Detected in many" "cervical cancer: 10.0;head and neck cancer: 9.8" "Low region specificity" "Detected in single" "Low cell type specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low region specificity" "Detected in single" HPA021030 Approved Nucleoplasm,Centrosome,Cytosol "Secreted in other tissues" 480000 Nucleoplasm "Centrosome, Cytosol" "HPA021030: AB_1846010" "unprognostic (7.60e-3)" "unprognostic (4.00e-2)" "unprognostic (1.59e-3)" "unprognostic (3.63e-3)" "unprognostic (2.24e-2)" "unprognostic (2.91e-2)" "unprognostic (2.78e-2)" "unprognostic (4.36e-3)" "unprognostic (3.23e-1)" "unprognostic (5.79e-2)" "unprognostic (2.37e-3)" "unprognostic (6.49e-2)" "unprognostic (6.21e-10)" "unprognostic (2.39e-1)" "unprognostic (1.67e-1)" "unprognostic (7.56e-2)" "prognostic unfavourable (1.31e-4)" 2.7 2.3 0.1 0.4 0.4 0.2 2.8 0.1 0.4 8.1 1.1 0.3 0.1 0.1 1.1 1.2 18.0 0.2 0.2 4.4 0.1 1.2 1.2 0.2 0.8 0.3 0.1 0.1 1.8 6.9 0.1 1.1 8.8 0.9 0.3 0.1 0.6 4.4 0.1 0.3 41.0 0.5 0.7 0.7 1.7 0.2 2.2 0.1 0.8 0.1 12.3 2.3 1.7 6.7 0.4 0.4 1.6 0.4 1.5 0.4 0.1 20.2 1.1 0.0 0.0 0.1 0.3 0.0 16.2 30.8 16.6 4.1 0.1 1.7 0.0 3.2 6.9 1.2 0.0 8.9 17.2 0.1 0.0 0.0 6.5 0.4 0.4 0.0 0.0 0.2 14.5 1.5 2.1 0.0 0.0 0.0 62.5 0.0 0.0 0.0 0.1 2.4 0.0 16.7 0.0 7.8 0.8 0.0 0.0 10.7 5.1 0.1 0.1 0.0 12.4 4.0 34.2 1.3 1.6 0.0 0.0 0.0 61.4 0.0 0.1 1.0 0.4 0.4 0.4 0.1 0.2 0.3 0.2 0.3 0.0 0.4 0.3 0.3 1.6 1.5 0.2 0.4 0.3 0.1 0.1 0.4 0.1 0.3 0.1 1.2 0.1 0.1 0.9 0.1 CPA5 ENSG00000158525 "Carboxypeptidase A5" Q8WXQ8 7 130344816-130368730 "Enzymes, Predicted intracellular proteins, Predicted secreted proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 17 "blood: 25.2;testis: 30.4" "Cell line enhanced" "Detected in some" "RH-30: 10.9;RT4: 4.9;U-266/84: 8.2" "Not detected" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 4 "memory CD4 T-cell: 8.0;naive CD8 T-cell: 20.3;T-reg: 25.2" "Lineage enriched" "Detected in single" 114 "T-cells: 25.2" "Not detected" "Not detected" "Low region specificity" "Detected in many" HPA020322 Approved Nucleoplasm "Secreted in male reproductive system" Nucleoplasm "HPA020322: AB_10960562" "unprognostic (2.44e-1)" "unprognostic (3.76e-1)" "unprognostic (1.50e-1)" "unprognostic (5.94e-2)" "unprognostic (4.96e-2)" "unprognostic (7.10e-3)" "unprognostic (1.64e-2)" "unprognostic (1.41e-2)" "unprognostic (3.26e-1)" "unprognostic (5.02e-2)" "unprognostic (5.83e-4)" "unprognostic (1.43e-1)" "unprognostic (8.88e-13)" "unprognostic (5.16e-2)" "unprognostic (1.32e-1)" "unprognostic (8.81e-2)" "unprognostic (3.08e-2)" 0.1 0.1 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.0 0.1 0.4 0.1 0.0 0.1 0.1 0.1 0.4 0.1 0.1 0.1 1.6 0.1 0.1 0.1 0.4 0.0 1.0 0.5 0.1 0.1 0.0 0.1 0.1 0.1 0.1 0.8 0.4 0.1 0.1 1.6 0.0 30.4 0.1 0.1 0.1 0.1 0.7 0.8 0.1 0.0 0.0 0.2 0.0 0.0 25.2 3.1 0.8 0.0 0.1 0.6 0.0 0.0 0.0 0.4 3.2 0.2 0.4 2.4 0.0 0.0 0.0 0.0 0.1 0.4 0.6 0.0 0.0 1.8 0.7 0.7 1.2 0.5 0.0 0.0 0.0 1.1 0.0 1.2 0.0 0.0 1.6 0.1 0.0 0.4 0.0 0.8 0.0 0.0 10.9 0.3 1.4 4.9 1.4 0.2 0.0 3.1 0.0 0.0 0.0 0.0 0.0 2.2 0.0 0.1 0.0 8.2 0.0 0.4 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.3 0.0 8.0 4.1 0.0 0.0 2.1 20.3 0.0 0.0 0.0 0.0 25.2 3.1 0.1 0.1 0.1 0.1 0.1 0.4 0.1 0.1 0.1 0.1 CPA6 CPAH ENSG00000165078 "Carboxypeptidase A6" Q8N4T0 8 67422038-67746385 "Disease related genes, Enzymes, Potential drug targets, Predicted secreted proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Disease mutation, Epilepsy" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 16.2;prostate: 10.6;retina: 13.0" "Cell line enhanced" "Detected in some" "ASC TERT1: 2.0;CACO-2: 6.2;EFO-21: 3.5;Hep G2: 9.5" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Region enriched" "Detected in single" 10 "olfactory region: 15.5" "Low region specificity" "Detected in all" "Secreted to extracellular matrix" "unprognostic (2.85e-2)" "unprognostic (1.95e-1)" "unprognostic (1.72e-2)" "unprognostic (1.14e-1)" "unprognostic (2.58e-1)" "unprognostic (2.24e-1)" "unprognostic (2.08e-1)" "unprognostic (2.88e-1)" "unprognostic (9.35e-2)" "unprognostic (1.65e-1)" "unprognostic (5.23e-2)" "unprognostic (6.99e-2)" "unprognostic (3.57e-4)" "unprognostic (9.61e-5)" "unprognostic (1.75e-1)" "unprognostic (9.09e-2)" "unprognostic (1.41e-2)" 0.2 0.1 0.1 9.8 0.1 0.2 0.2 0.1 0.1 9.4 16.2 0.7 0.8 0.2 8.3 1.7 3.7 0.2 0.3 0.1 0.2 0.1 0.3 0.1 0.7 0.1 0.2 0.0 0.1 0.1 0.1 0.2 0.3 0.3 10.6 7.2 13.0 0.1 0.7 0.1 0.2 1.3 3.4 0.7 0.3 0.5 1.3 0.0 0.0 0.2 1.5 0.6 4.1 5.5 0.0 0.6 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.2 0.0 0.0 6.2 0.0 0.0 3.5 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 9.5 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 1.1 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 1.7 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.1 0.1 0.1 0.1 0.2 0.1 0.2 0.0 0.3 0.0 CPB1 ENSG00000153002 "Carboxypeptidase B1" P15086 3 148791102-148860187 "Enzymes, Plasma proteins, Predicted secreted proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 590 "pancreas: 3628.4" "Cell line enhanced" "Detected in some" "ASC diff: 2.7;EFO-21: 2.9;HDLM-2: 3.0;U-2 OS: 5.1;U-251 MG: 1.5;U-266/84: 2.4" "Group enriched" "Detected in some" 312 "breast cancer: 293.8;pancreatic cancer: 641.4" "Not detected" "Not detected" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in some" "Low region specificity" "Detected in some" "CAB026158, HPA038069, HPA046340" Enhanced "Secreted to digestive system" 6600000 "CAB026158: , HPA038069: , HPA046340: " "unprognostic (6.90e-2)" "unprognostic (3.79e-2)" "unprognostic (3.34e-2)" "unprognostic (2.64e-2)" "unprognostic (5.58e-2)" "unprognostic (3.27e-2)" "unprognostic (6.26e-4)" "unprognostic (1.90e-1)" "unprognostic (1.82e-1)" "unprognostic (1.07e-1)" "unprognostic (7.59e-2)" "unprognostic (4.51e-2)" "unprognostic (5.50e-8)" "unprognostic (3.08e-1)" "unprognostic (1.60e-1)" "unprognostic (4.93e-2)" 0.2 1.7 0.1 0.1 0.2 0.0 0.7 0.1 0.2 0.1 0.1 0.1 0.1 0.2 0.1 0.1 0.1 0.0 0.1 0.2 0.1 0.0 0.1 0.1 0.1 0.1 0.1 0.1 1.2 3628.4 0.0 0.1 0.1 0.1 0.1 0.0 0.1 0.2 0.1 0.1 0.0 0.1 0.1 0.1 0.7 0.2 0.4 0.2 0.1 0.1 0.1 0.1 0.1 0.1 1.8 1.1 6.1 1.0 3.1 3.5 0.9 0.0 0.0 0.0 0.0 2.7 0.7 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.8 2.9 0.0 0.0 0.0 0.0 0.1 3.0 0.5 0.6 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.0 0.0 0.0 0.2 5.1 0.0 1.5 0.0 2.4 0.6 0.0 0.0 0.0 6.1 0.7 1.1 3.0 0.9 2.2 0.9 1.3 2.6 0.3 1.8 0.9 3.5 4.5 3.1 1.0 1.1 0.6 0.9 0.1 0.2 0.1 0.2 0.1 0.0 0.1 0.1 0.1 0.2 CPB2 "CPU, PCPB, TAFI" ENSG00000080618 "Carboxypeptidase B2" Q96IY4 13 46053195-46105033 "Enzymes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins" "Blood coagulation, Fibrinolysis, Hemostasis" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 82 "liver: 246.8" "Cell line enriched" "Detected in single" 76 "Hep G2: 61.1" "Cancer enriched" "Detected in some" 112 "liver cancer: 268.4" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in many" HPA004146 Approved "Secreted to blood" 14000000000 "HPA004146: AB_1078397" "unprognostic (3.44e-2)" "unprognostic (1.25e-1)" "unprognostic (2.94e-2)" "unprognostic (1.89e-2)" "unprognostic (7.69e-2)" "unprognostic (1.17e-2)" "prognostic favourable (2.06e-4)" "unprognostic (1.89e-1)" "unprognostic (2.74e-1)" "unprognostic (2.48e-1)" "unprognostic (3.17e-2)" "unprognostic (4.83e-2)" "unprognostic (3.20e-3)" "unprognostic (1.34e-1)" "unprognostic (7.10e-2)" "unprognostic (3.34e-2)" "unprognostic (9.61e-2)" 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.7 0.0 0.0 0.0 0.0 246.8 3.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.2 0.5 0.5 0.4 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 61.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.1 0.0 0.0 0.3 0.0 0.6 0.0 0.0 0.4 0.2 0.1 0.0 0.0 0.4 0.2 0.5 0.4 0.5 0.2 0.6 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 CPD GP180 ENSG00000108582 "Carboxypeptidase D" O75976 17 30378905-30469989 "Enzymes, Predicted intracellular proteins, Predicted membrane proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HSkMC: 57.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Cell type enhanced" "Detected in many" "neutrophil: 19.3" "Low lineage specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA052796, HPA055465" Approved Approved "Nucleoplasm,Nuclear membrane,Nuclear speckles" 930000 "Nucleoplasm, Nuclear speckles" "Nuclear membrane" "HPA052796: , HPA055465: " "unprognostic (1.05e-1)" "unprognostic (1.31e-1)" "unprognostic (3.05e-2)" "unprognostic (3.62e-2)" "unprognostic (6.13e-2)" "unprognostic (1.65e-1)" "unprognostic (7.97e-3)" "unprognostic (4.45e-2)" "unprognostic (2.07e-2)" "unprognostic (2.96e-1)" "unprognostic (1.62e-1)" "unprognostic (3.16e-1)" "unprognostic (1.58e-1)" "unprognostic (3.74e-2)" "unprognostic (7.25e-2)" "unprognostic (3.36e-1)" "unprognostic (1.08e-1)" 16.4 8.0 9.8 12.3 12.4 18.1 17.9 9.1 13.3 28.6 16.2 18.5 10.1 12.9 12.6 10.1 10.0 15.2 33.6 10.5 12.8 10.4 13.4 26.8 20.0 14.2 22.1 11.4 7.8 14.7 21.2 14.9 22.3 13.9 11.4 13.3 7.5 59.7 7.9 10.0 7.8 22.0 15.1 25.9 7.9 24.6 25.0 13.5 5.8 37.2 7.7 10.0 11.5 11.6 0.4 3.4 19.3 5.5 2.1 3.8 2.5 12.1 18.5 16.1 16.5 16.8 32.0 5.8 16.8 24.6 11.7 14.4 21.7 7.9 1.5 21.4 19.2 8.7 10.4 21.2 19.7 5.7 14.9 3.4 11.4 13.4 20.4 22.6 9.1 57.0 9.5 14.9 14.5 23.6 6.7 18.0 9.3 2.3 7.2 6.2 4.5 4.2 7.0 18.7 4.7 21.8 13.9 4.0 10.2 20.0 17.3 8.7 16.4 15.7 28.1 11.7 7.7 18.1 16.0 7.2 15.1 5.1 14.9 14.8 9.8 2.8 5.5 6.4 3.4 2.8 3.8 0.2 1.7 2.8 3.4 0.4 1.4 1.7 19.3 2.1 2.3 0.4 1.1 2.5 9.8 12.4 9.1 13.3 12.8 10.4 22.1 11.4 13.9 13.5 CPE ENSG00000109472 "Carboxypeptidase E" P16870 4 165361194-165498320 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 203.7" "Cell line enhanced" "Detected in many" "Hep G2: 49.9;SCLC-21H: 70.2;SiHa: 103.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Cell type enhanced" "Detected in single" "T-reg: 1.5" "Lineage enriched" "Detected in single" 16 "T-cells: 1.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA003819, CAB024907" Supported Approved Nucleoplasm,Vesicles,Centrosome "Intracellular and membrane" 470000 Centrosome "Nucleoplasm, Vesicles" "CAB024907: , HPA003819: " "unprognostic (1.84e-1)" "unprognostic (5.64e-3)" "unprognostic (1.61e-1)" "unprognostic (1.70e-2)" "unprognostic (2.51e-1)" "unprognostic (1.44e-2)" "unprognostic (1.65e-1)" "unprognostic (9.52e-2)" "unprognostic (2.91e-3)" "unprognostic (9.01e-2)" "unprognostic (4.84e-3)" "unprognostic (5.56e-3)" "prognostic unfavourable (2.60e-4)" "unprognostic (4.35e-3)" "unprognostic (1.46e-1)" "unprognostic (2.26e-1)" "prognostic unfavourable (2.12e-4)" 27.7 33.8 123.1 4.4 135.5 0.9 21.5 82.9 203.7 10.7 9.6 31.6 5.3 5.0 13.3 94.3 16.4 15.7 14.0 19.6 116.9 56.3 12.0 6.3 11.0 7.6 56.9 70.7 23.4 35.5 33.9 40.0 2.2 53.0 66.5 8.8 13.2 12.0 20.1 11.0 5.5 6.2 18.5 40.5 2.8 19.2 30.4 53.3 0.9 40.7 4.3 7.7 6.3 9.4 0.0 0.0 0.0 0.0 0.0 1.5 0.0 0.0 1.3 9.0 1.7 7.2 0.8 0.4 0.0 3.6 1.3 2.9 0.0 0.0 0.0 2.6 0.0 0.2 3.4 0.7 0.8 0.0 13.2 0.0 3.7 49.9 0.5 0.0 0.0 17.6 3.7 0.0 0.0 0.0 0.0 0.3 1.8 2.5 0.0 0.4 5.7 2.0 0.0 0.0 0.1 0.1 0.5 70.2 23.2 103.0 12.9 0.0 7.7 0.3 0.0 2.8 7.2 0.2 0.2 3.9 0.0 0.3 2.6 0.1 0.8 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.5 0.0 123.1 135.5 82.9 82.2 116.9 56.3 56.9 70.7 53.0 53.3 CPM ENSG00000135678 "Carboxypeptidase M" P14384 12 68842197-68971570 "Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "adipose tissue: 56.1" "Cell line enhanced" "Detected in many" "ASC diff: 28.8;ASC TERT1: 20.5;HSkMC: 37.0;SiHa: 27.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Cell type enhanced" "Detected in many" "classical monocyte: 15.5;myeloid DC: 11.9" "Group enriched" "Detected in many" 5 "dendritic cells: 11.9;monocytes: 15.5" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "HPA002657, HPA077243" Enhanced Uncertain Vesicles 5000000 Vesicles "HPA002657: AB_1078398, HPA077243: " "unprognostic (1.74e-1)" "unprognostic (3.11e-1)" "unprognostic (2.88e-3)" "prognostic favourable (1.00e-4)" "unprognostic (4.58e-2)" "unprognostic (8.61e-2)" "unprognostic (1.57e-2)" "unprognostic (2.01e-1)" "unprognostic (8.42e-2)" "unprognostic (1.40e-1)" "unprognostic (1.35e-1)" "unprognostic (1.42e-1)" "unprognostic (1.47e-3)" "unprognostic (8.58e-2)" "unprognostic (6.85e-2)" "unprognostic (2.59e-2)" "unprognostic (1.06e-1)" 56.1 6.6 3.8 5.4 7.0 1.1 37.2 1.2 4.9 6.5 12.9 13.2 0.9 1.6 10.7 6.1 4.1 6.4 6.5 2.9 5.3 3.0 22.1 11.6 24.1 13.0 10.9 4.3 7.5 7.8 3.2 1.0 27.9 5.5 6.2 10.8 2.7 3.2 1.7 8.2 13.0 3.7 2.5 6.7 11.4 5.9 5.8 9.3 1.1 5.1 3.5 4.5 4.4 4.4 2.8 11.9 1.3 15.5 0.3 1.3 4.7 0.0 1.5 0.0 0.0 28.8 20.5 0.3 3.8 0.4 0.6 0.9 1.2 1.6 0.2 3.8 0.5 0.0 0.5 1.0 1.6 0.0 1.0 0.0 6.2 0.1 0.1 0.4 0.7 37.0 0.2 0.4 0.8 0.0 0.0 0.0 2.9 0.6 0.0 0.2 0.6 2.0 1.1 0.2 0.0 2.9 2.2 0.1 0.0 27.1 4.2 3.2 0.4 10.1 0.1 0.5 3.1 0.2 0.0 0.1 0.1 4.9 1.7 5.1 2.3 0.3 15.5 0.1 0.1 10.2 0.0 1.4 1.2 0.0 11.9 2.8 0.7 0.1 1.3 0.3 4.7 0.8 1.3 4.7 3.8 7.0 1.2 4.9 5.3 3.0 10.9 4.3 5.5 9.3 CPN1 ENSG00000120054 "Carboxypeptidase N subunit 1" P15169 10 100042193-100081877 "Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Disease mutation" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 127 "liver: 76.8" "Cell line enriched" "Detected in some" 17 "SK-MEL-30: 55.2" "Group enriched" "Detected in some" 12 "liver cancer: 26.6;melanoma: 7.9" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in some" "Low region specificity" "Detected in all" "Secreted to blood" 22000000000 "unprognostic (2.97e-2)" "unprognostic (2.23e-2)" "unprognostic (3.93e-2)" "unprognostic (1.64e-1)" "unprognostic (6.75e-2)" "unprognostic (2.93e-2)" "unprognostic (5.26e-2)" "unprognostic (2.63e-1)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 76.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.2 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 55.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.1 0.0 0.2 0.1 0.1 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 CPO ENSG00000144410 "Carboxypeptidase O" Q8IVL8 2 206939554-206969474 "Enzymes, Predicted intracellular proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 7 "intestine: 71.1" "Cell line enhanced" "Detected in some" "ASC diff: 2.9;BEWO: 1.7;hTCEpi: 2.2;NB-4: 4.0" "Not detected" "Not detected" "Not detected" "Not detected" "Cell type enriched" "Detected in single" 17 "basophil: 10.3" "Lineage enriched" "Detected in single" 42 "granulocytes: 10.3" "Low region specificity" "Detected in many" "Intracellular and membrane" "unprognostic (9.39e-2)" "unprognostic (2.64e-1)" "unprognostic (2.95e-2)" "unprognostic (5.21e-2)" "unprognostic (2.28e-1)" "unprognostic (1.27e-2)" "unprognostic (1.16e-1)" "unprognostic (9.06e-2)" "unprognostic (4.03e-1)" "unprognostic (1.33e-1)" "unprognostic (3.75e-3)" "unprognostic (1.22e-1)" "unprognostic (3.60e-2)" "unprognostic (2.52e-1)" "unprognostic (6.56e-2)" "unprognostic (4.03e-2)" "unprognostic (4.89e-2)" 0.2 0.4 0.2 0.1 0.9 0.0 0.3 0.1 0.4 0.2 0.6 0.1 1.1 0.1 0.1 9.4 0.1 0.1 0.1 0.1 0.2 0.5 0.5 0.2 0.1 0.1 0.2 0.1 0.1 0.1 0.6 0.5 0.1 0.1 0.3 0.1 0.1 0.3 0.3 0.2 0.1 71.1 0.2 0.1 0.1 0.1 0.3 0.1 0.1 0.4 0.1 0.1 0.1 0.1 0.0 0.0 10.3 0.0 0.0 0.2 0.0 0.0 0.3 0.3 0.0 2.9 1.0 1.7 0.4 0.0 0.0 0.1 0.3 0.2 0.1 0.7 0.0 0.0 0.3 0.2 0.1 0.2 0.5 0.0 0.0 0.2 0.0 0.7 0.2 0.9 2.2 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.1 4.0 0.2 0.6 0.1 0.0 0.2 1.5 0.1 0.3 0.0 0.0 0.3 0.0 0.2 0.6 0.0 0.0 1.0 0.7 0.4 0.1 0.9 0.0 0.0 0.3 0.5 10.3 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.9 0.1 0.4 0.2 0.5 0.2 0.1 0.1 0.1 CPQ "LDP, PGCP" ENSG00000104324 "Carboxypeptidase Q" Q9Y646 8 96645227-97149654 "Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "thyroid gland: 94.4" "Cell line enhanced" "Detected in many" "ASC diff: 37.7;ASC TERT1: 43.3;Karpas-707: 31.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Cell type enhanced" "Detected in all" "neutrophil: 62.6" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA023235, HPA024490" Enhanced Supported "Golgi apparatus,Vesicles" "Secreted to blood" 51000000 "Golgi apparatus, Vesicles" "HPA023235: AB_1855257, HPA024490: AB_1855258" "unprognostic (4.04e-2)" "unprognostic (5.46e-2)" "unprognostic (4.45e-2)" "unprognostic (1.68e-1)" "unprognostic (1.51e-3)" "unprognostic (3.98e-3)" "unprognostic (5.24e-2)" "unprognostic (2.92e-2)" "unprognostic (2.67e-2)" "unprognostic (9.19e-2)" "unprognostic (2.38e-3)" "unprognostic (6.16e-3)" "prognostic favourable (5.40e-5)" "unprognostic (6.74e-3)" "unprognostic (8.71e-2)" "unprognostic (3.21e-2)" "unprognostic (1.75e-1)" 17.4 12.6 12.5 10.1 18.3 9.5 15.4 8.3 11.3 26.3 16.5 19.4 21.1 9.4 24.5 19.5 9.1 16.8 20.0 24.1 14.0 9.2 26.4 22.1 13.9 12.3 27.6 8.8 35.3 18.8 20.7 14.2 12.4 16.6 18.1 10.9 19.8 10.9 18.6 5.0 9.1 14.1 30.8 15.3 12.9 14.5 7.3 24.5 1.3 94.4 8.1 7.2 16.9 19.3 1.8 12.8 62.6 17.5 6.3 7.3 8.4 0.6 1.9 1.6 0.4 37.7 43.3 0.5 11.5 17.5 4.1 8.5 1.3 0.8 1.1 9.4 18.2 0.6 0.7 0.8 3.9 10.4 1.5 9.8 1.8 5.7 8.3 2.3 12.7 22.6 2.1 4.7 1.2 1.8 9.5 31.5 9.2 0.6 0.3 4.8 1.2 1.9 2.2 0.3 0.5 8.5 4.4 1.2 0.8 4.1 0.4 8.9 4.4 9.5 8.2 18.0 2.1 0.8 4.2 3.1 0.7 0.4 11.4 7.8 11.9 5.4 17.5 10.8 7.3 12.0 7.3 1.5 5.5 6.3 12.8 1.8 5.0 6.7 62.6 6.3 11.0 3.7 5.7 8.4 12.5 18.3 8.3 11.3 14.0 9.2 27.6 8.8 16.6 24.5 CPVL ENSG00000106066 "Carboxypeptidase, vitellogenic like" Q9H3G5 7 28995231-29195451 "Enzymes, Predicted intracellular proteins" "Carboxypeptidase, Hydrolase, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "blood: 111.9;lymphoid tissue: 84.0" "Cell line enriched" "Detected in many" 4 "RPTEC TERT1: 129.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Cell type enhanced" "Detected in many" "classical monocyte: 95.8;intermediate monocyte: 81.6;myeloid DC: 111.9" "Group enriched" "Detected in many" 52 "dendritic cells: 111.9;monocytes: 95.8" "Not detected" "Not detected" "Low region specificity" "Detected in all" "CAB003697, HPA045715, HPA056466" Enhanced Supported "Endoplasmic reticulum" "Intracellular and membrane" 510000 "Endoplasmic reticulum" "CAB003697: AB_425990, HPA045715: , HPA056466: " "unprognostic (4.72e-2)" "unprognostic (7.08e-2)" "unprognostic (5.96e-2)" "prognostic unfavourable (8.56e-6)" "unprognostic (1.63e-1)" "unprognostic (2.49e-2)" "unprognostic (6.85e-3)" "unprognostic (7.01e-2)" "unprognostic (1.49e-1)" "unprognostic (4.98e-2)" "unprognostic (3.07e-1)" "unprognostic (4.25e-2)" "unprognostic (1.56e-2)" "unprognostic (1.79e-3)" "unprognostic (2.21e-1)" "unprognostic (7.46e-3)" "prognostic unfavourable (4.99e-4)" 19.0 6.2 4.0 15.0 9.1 11.9 7.7 11.6 3.4 9.1 10.0 7.7 4.2 7.6 6.9 20.4 6.4 7.2 10.2 30.2 6.1 4.4 39.1 12.3 13.5 30.5 6.6 2.3 10.1 8.5 0.2 6.1 31.3 20.1 8.4 6.0 15.8 3.5 5.2 7.9 5.1 13.3 8.1 9.7 84.0 4.7 10.6 4.2 29.7 51.9 5.0 8.1 11.0 15.7 0.1 111.9 1.9 95.8 0.5 0.3 74.4 0.2 0.0 3.2 0.0 0.0 0.0 30.9 0.0 0.0 0.3 0.0 9.3 0.0 0.0 14.7 0.1 0.5 8.2 0.6 0.1 0.0 7.6 10.4 0.1 22.3 0.0 0.0 0.0 0.0 0.9 0.1 0.2 0.1 6.9 0.0 0.2 0.0 9.6 0.0 5.0 2.5 0.0 0.0 0.0 129.2 3.5 1.9 1.5 8.5 20.2 15.6 2.4 7.7 0.0 0.0 0.1 0.0 1.8 2.8 31.1 0.1 0.0 3.9 3.3 1.0 95.8 0.4 0.2 81.6 0.3 0.1 0.1 0.1 111.9 0.1 0.1 0.1 1.9 0.5 26.0 2.9 0.1 74.4 4.0 9.1 11.6 3.4 6.1 4.4 6.6 2.3 20.1 4.2 CPXM1 "CPX-1, CPX1, CPXM" ENSG00000088882 "Carboxypeptidase X, M14 family member 1" Q96SM3 20 2794069-2800637 "Enzymes, Predicted secreted proteins" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "placenta: 60.3" "Cell line enhanced" "Detected in some" "AF22: 45.0;HSkMC: 24.4;NB-4: 39.4;REH: 40.2;SH-SY5Y: 30.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Group enriched" "Detected in some" 22 "memory B-cell: 2.3;myeloid DC: 1.4;NK-cell: 3.9;plasmacytoid DC: 1.1" "Group enriched" "Detected in many" 26 "B-cells: 2.3;dendritic cells: 1.4;NK-cells: 3.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" "Secreted in other tissues" "unprognostic (7.48e-2)" "unprognostic (3.61e-1)" "unprognostic (6.70e-2)" "unprognostic (1.47e-2)" "unprognostic (3.41e-1)" "unprognostic (5.24e-2)" "unprognostic (1.82e-2)" "unprognostic (1.84e-2)" "unprognostic (2.98e-2)" "unprognostic (9.32e-2)" "unprognostic (7.02e-2)" "unprognostic (3.23e-2)" "prognostic unfavourable (4.62e-10)" "unprognostic (1.30e-1)" "unprognostic (1.49e-1)" "unprognostic (5.55e-3)" "unprognostic (1.27e-2)" 24.0 2.4 0.5 4.6 1.1 5.6 14.9 0.9 3.7 32.2 7.4 1.3 7.6 0.2 43.6 41.4 1.4 13.6 31.1 14.4 0.5 0.2 4.3 0.6 2.7 1.9 2.1 0.6 20.7 1.7 0.6 2.7 60.3 2.4 8.5 0.2 16.2 2.7 5.3 2.2 5.8 1.4 14.5 1.4 0.5 1.0 10.1 0.3 15.2 8.8 0.7 1.5 23.0 15.2 2.3 1.4 0.0 0.0 3.9 0.0 0.7 0.0 0.0 45.0 0.0 0.0 1.4 0.0 0.1 0.2 0.5 0.1 0.0 0.0 0.0 0.1 0.0 0.0 3.3 0.0 0.1 0.2 2.3 5.9 0.0 0.0 0.6 0.0 0.9 24.4 0.0 2.1 0.0 0.0 2.4 0.0 0.0 0.0 0.1 39.4 9.5 0.0 40.2 0.0 1.1 0.0 0.0 0.0 30.2 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.3 0.0 0.0 1.4 0.0 0.0 0.0 0.0 3.9 0.0 1.1 0.0 0.7 0.5 1.1 0.9 1.1 0.5 0.2 2.1 0.6 2.4 0.3 CPXM2 "CPX2, UNQ676" ENSG00000121898 "Carboxypeptidase X, M14 family member 2" Q8N436 10 123706207-123940267 "Enzymes, Predicted intracellular proteins, Predicted secreted proteins" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Group enriched" "Detected in some" 19 "BJ: 9.9;fHDF/TERT166: 38.8" "Low cancer specificity" "Detected in all" "Region enhanced" "Detected in many" "pons and medulla: 16.9" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in all" HPA048375 Uncertain "Secreted - unknown location" "HPA048375: " "unprognostic (1.50e-1)" "unprognostic (3.66e-1)" "unprognostic (2.58e-2)" "unprognostic (4.02e-3)" "unprognostic (2.69e-2)" "unprognostic (6.48e-2)" "unprognostic (1.32e-2)" "unprognostic (1.32e-2)" "unprognostic (1.26e-1)" "unprognostic (8.57e-2)" "unprognostic (4.42e-2)" "unprognostic (2.14e-1)" "prognostic favourable (9.02e-4)" "unprognostic (3.48e-2)" "unprognostic (2.54e-2)" "unprognostic (1.27e-1)" "unprognostic (1.16e-3)" 17.0 4.1 0.8 5.0 2.1 0.1 12.3 1.3 1.6 6.4 40.9 6.7 5.7 3.8 12.2 37.8 20.0 9.1 9.4 14.3 1.7 4.0 6.6 1.5 4.6 3.7 6.1 0.7 12.8 3.2 1.9 7.1 11.6 16.9 14.7 4.5 26.5 5.6 8.3 5.0 4.5 9.1 45.5 21.6 13.8 14.4 7.7 3.4 2.6 9.5 11.9 4.0 32.5 20.0 0.0 0.0 0.0 0.2 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 9.9 0.4 0.6 0.0 0.0 0.0 0.0 0.0 38.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.8 2.1 1.3 1.6 1.7 4.0 6.1 0.7 16.9 3.4 CPZ ENSG00000109625 "Carboxypeptidase Z" Q66K79 4 8592660-8619759 "Enzymes, Predicted intracellular proteins, Predicted secreted proteins" "Wnt signaling pathway" "Carboxypeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "ovary: 63.2" "Cell line enhanced" "Detected in some" "BEWO: 29.2;BJ: 16.8;BJ hTERT+: 22.6;RH-30: 24.8;U-2197: 18.1" "Low cancer specificity" "Detected in some" "Low region specificity" "Detected in many" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in many" HPA078608 Approved "Plasma membrane" "Secreted to extracellular matrix" "Plasma membrane" "HPA078608: " "unprognostic (2.58e-1)" "unprognostic (7.16e-2)" "unprognostic (4.83e-2)" "unprognostic (1.42e-1)" "unprognostic (7.77e-2)" "unprognostic (2.20e-2)" "unprognostic (2.98e-1)" "unprognostic (7.77e-2)" "unprognostic (2.30e-1)" "unprognostic (1.95e-2)" "unprognostic (1.41e-1)" "unprognostic (1.59e-1)" "unprognostic (7.23e-8)" "unprognostic (4.30e-3)" "unprognostic (3.58e-2)" "unprognostic (6.13e-4)" "unprognostic (5.51e-2)" 4.3 0.9 0.3 2.8 1.1 0.0 5.4 1.1 1.6 15.7 1.8 1.5 27.1 0.1 7.9 24.1 3.0 7.4 12.9 2.4 0.4 0.3 1.5 0.8 2.9 0.7 1.5 0.4 63.2 1.1 0.3 2.3 18.9 2.3 4.1 0.5 4.4 0.8 20.6 0.3 5.5 1.2 10.3 1.3 0.7 1.7 4.4 0.1 1.6 3.5 0.1 2.2 9.8 11.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 10.3 0.1 0.0 0.7 2.2 0.2 29.2 16.8 22.6 6.3 2.5 0.7 0.3 0.0 1.6 9.2 0.0 0.0 0.0 2.4 0.0 1.2 0.0 0.1 0.3 2.0 0.0 0.0 4.1 0.0 0.0 0.0 0.0 0.4 0.0 0.4 2.5 0.0 0.0 3.9 9.2 0.0 24.8 0.0 0.0 0.5 0.0 0.0 0.6 0.2 0.0 0.1 0.0 0.0 0.9 1.2 18.1 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 1.1 1.1 1.6 0.4 0.3 1.5 0.4 2.3 0.1 CTRB1 CTRB ENSG00000168925 "Chymotrypsinogen B1" P17538 16 75219000-75226338 "Enzymes, Predicted intracellular proteins, Predicted secreted proteins" Digestion "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enriched" "Detected in single" 2272 "pancreas: 1908.8" "Cell line enhanced" "Detected in some" "EFO-21: 6.3;HDLM-2: 4.9;U-2 OS: 2.4;U-251 MG: 1.6" "Cancer enriched" "Detected in some" 1905 "pancreatic cancer: 962.5" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Secreted to digestive system" "unprognostic (1.76e-1)" "unprognostic (2.62e-1)" "unprognostic (3.55e-1)" "unprognostic (1.57e-1)" "unprognostic (5.22e-2)" "unprognostic (4.43e-3)" "unprognostic (2.96e-1)" "unprognostic (1.17e-2)" 0.2 0.0 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.0 0.2 0.2 0.1 0.0 0.1 0.1 0.1 0.1 0.1 0.1 0.8 1908.8 0.0 0.1 0.1 0.1 0.1 0.0 0.1 0.2 0.1 0.1 0.0 0.1 0.1 0.1 0.1 0.0 0.4 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.7 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.2 0.0 0.0 0.0 6.3 0.0 0.0 0.0 0.0 0.0 4.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 2.4 0.2 1.6 0.0 0.1 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.1 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.1 CTRB2 ENSG00000168928 "Chymotrypsinogen B2" Q6GPI1 16 75204096-75207185 "Enzymes, Predicted intracellular proteins, Predicted secreted proteins" Digestion "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 5240 "pancreas: 3761.5" "Cell line enhanced" "Detected in some" "EFO-21: 5.0;HDLM-2: 1.9;U-2 OS: 9.0;U-251 MG: 1.9;U-266/84: 2.6;U-698: 2.4" "Cancer enriched" "Detected in single" 1696 "pancreatic cancer: 540.0" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Secreted to digestive system" "unprognostic (9.41e-4)" "unprognostic (2.20e-1)" "unprognostic (1.28e-2)" "unprognostic (2.10e-1)" "unprognostic (2.92e-2)" "unprognostic (2.77e-1)" "unprognostic (5.95e-2)" "unprognostic (9.56e-2)" "unprognostic (3.54e-3)" "unprognostic (7.06e-2)" "unprognostic (2.17e-1)" "unprognostic (7.57e-2)" 0.1 0.0 0.1 0.1 0.1 0.0 0.1 0.1 0.2 0.1 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.1 0.1 0.1 0.6 3761.5 0.0 0.1 0.1 0.1 0.1 0.0 0.1 0.2 0.1 0.1 0.0 0.1 0.1 0.1 0.1 0.0 0.7 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.3 0.0 0.1 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.3 0.0 5.0 0.0 0.0 0.0 0.0 0.0 1.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.3 0.0 0.0 0.0 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 9.0 0.0 1.9 0.1 2.6 2.4 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.1 0.2 0.1 0.0 0.1 0.1 0.1 0.1 CTRC "CLCR, ELA4" ENSG00000162438 "Chymotrypsin C" Q99895 1 15438439-15449242 "Disease related genes, Enzymes, Potential drug targets, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Disease mutation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 417 "pancreas: 1443.7" "Cell line enhanced" "Detected in some" "A-431: 3.6" "Cancer enriched" "Detected in some" 168 "pancreatic cancer: 236.0" "Not detected" "Not detected" "Cell type enhanced" "Detected in some" "basophil: 3.4" "Low lineage specificity" "Detected in many" "Not detected" "Not detected" "Not detected" "Not detected" HPA046920 Enhanced "Secreted to digestive system" "HPA046920: " "unprognostic (2.62e-2)" "unprognostic (2.58e-1)" "unprognostic (1.34e-1)" "unprognostic (2.81e-1)" "unprognostic (8.60e-2)" "unprognostic (1.06e-1)" "unprognostic (1.02e-1)" "unprognostic (1.23e-1)" "unprognostic (2.94e-2)" "unprognostic (7.60e-2)" "unprognostic (3.34e-1)" "unprognostic (2.00e-1)" "unprognostic (9.55e-11)" "unprognostic (4.98e-2)" "unprognostic (1.84e-1)" "unprognostic (1.50e-1)" "unprognostic (5.99e-3)" 0.1 0.0 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.1 0.1 0.1 0.6 1443.7 0.0 0.1 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.1 0.0 0.4 0.1 0.1 0.1 0.1 0.1 0.1 0.1 1.1 0.4 3.4 0.7 1.5 0.6 0.1 3.6 0.6 0.5 0.7 0.2 0.0 0.2 0.3 0.4 0.0 0.0 0.0 1.7 0.5 1.1 0.0 0.5 0.0 0.1 0.2 1.1 0.5 0.4 0.3 0.1 0.9 0.2 1.7 0.2 0.0 0.0 0.0 0.0 0.1 1.7 0.2 0.5 1.0 1.6 0.4 0.0 0.5 0.1 0.3 0.0 0.1 0.4 1.0 0.4 0.2 0.2 0.3 0.1 0.9 0.4 1.4 0.9 0.2 0.8 1.6 0.3 0.8 0.8 0.3 3.4 0.4 0.4 0.4 0.2 0.2 0.3 0.3 0.6 0.1 1.1 0.3 0.4 1.7 1.5 0.7 0.4 0.2 0.1 0.1 0.1 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.1 CTRL ENSG00000141086 "Chymotrypsin like" P40313 16 67927640-67932414 "Enzymes, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 281 "pancreas: 639.8" "Low cell line specificity" "Detected in many" "Not detected" "Not detected" "Not detected" "Not detected" "Low cell type specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected" "Not detected" "HPA034504, HPA034505" Enhanced "Secreted to digestive system" "HPA034504: AB_2674196, HPA034505: AB_10602212" "unprognostic (3.03e-5)" "unprognostic (3.53e-3)" "unprognostic (3.46e-2)" "unprognostic (1.37e-1)" "unprognostic (9.66e-2)" "unprognostic (2.00e-2)" "unprognostic (1.24e-1)" "unprognostic (2.23e-1)" "unprognostic (1.18e-1)" "unprognostic (6.83e-3)" "unprognostic (6.41e-2)" "unprognostic (1.88e-1)" "unprognostic (3.20e-4)" "unprognostic (6.69e-2)" "unprognostic (2.79e-1)" "unprognostic (2.63e-1)" "unprognostic (1.29e-3)" 0.1 0.0 0.1 0.1 0.1 0.2 0.1 0.2 0.1 0.1 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.1 0.1 0.1 0.3 639.8 0.0 0.1 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.2 0.0 0.2 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.6 1.1 1.1 0.7 0.0 2.2 0.5 0.5 3.7 1.1 0.3 0.2 0.1 1.8 0.3 0.7 1.1 1.3 2.3 1.4 0.7 0.4 0.7 1.0 5.6 0.7 3.1 1.4 6.3 0.7 1.1 1.4 0.3 0.9 2.5 1.2 0.2 3.9 1.0 0.0 1.5 1.0 0.6 1.0 0.7 2.7 6.2 2.2 2.8 0.5 4.5 0.0 0.9 2.6 1.4 1.3 0.7 0.6 1.2 4.3 1.6 0.1 2.0 0.5 1.6 6.5 2.7 3.6 0.2 0.8 0.8 0.6 0.7 0.3 1.5 0.7 0.2 0.3 1.1 0.5 0.9 0.6 0.5 2.2 1.1 0.0 0.7 1.1 0.0 0.5 0.1 0.1 0.2 0.1 0.1 0.0 0.1 0.1 0.1 0.1 CTSA "GSL, PPGB" ENSG00000064601 "Cathepsin A" P10619 20 45890144-45898820 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" "Carboxypeptidase, Hydrolase, Protease" "Disease mutation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "adrenal gland: 125.7" "Cell line enhanced" "Detected in all" "ASC diff: 116.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB024930, HPA031068" Enhanced Enhanced Vesicles "Intracellular and membrane" 18000000 Vesicles "CAB024930: , HPA031068: AB_10601205" "unprognostic (8.61e-2)" "unprognostic (3.37e-1)" "unprognostic (4.30e-2)" "unprognostic (2.13e-1)" "unprognostic (6.42e-2)" "unprognostic (2.21e-1)" "prognostic unfavourable (1.95e-4)" "unprognostic (6.33e-2)" "unprognostic (9.53e-3)" "unprognostic (7.19e-2)" "unprognostic (1.83e-1)" "unprognostic (6.85e-2)" "unprognostic (7.57e-2)" "unprognostic (1.09e-1)" "unprognostic (6.05e-2)" "unprognostic (1.71e-1)" "unprognostic (8.40e-2)" 29.0 125.7 12.0 22.8 19.5 22.1 35.3 11.4 30.0 14.1 50.6 17.4 16.2 29.4 18.2 19.3 20.7 12.7 28.0 32.6 11.5 11.6 88.2 43.8 28.4 38.9 12.3 16.1 23.9 19.2 28.3 16.5 47.7 15.7 18.2 50.5 30.1 20.5 15.1 19.3 28.2 40.6 19.6 11.9 38.8 19.7 14.3 11.2 8.0 18.1 24.9 22.4 23.3 18.7 7.0 16.6 81.1 46.1 12.0 31.2 50.0 14.4 14.9 2.8 12.7 116.2 60.2 6.4 20.8 55.4 22.8 29.7 27.9 38.9 3.1 24.1 38.9 23.1 7.5 14.0 14.3 6.0 7.0 8.2 10.4 48.6 25.9 13.0 33.9 47.8 16.9 14.7 3.3 24.8 8.1 47.8 24.7 29.7 3.3 12.0 2.8 35.4 5.2 14.5 17.2 18.2 12.7 5.6 5.3 34.6 60.6 58.0 14.8 18.7 22.8 45.8 10.7 25.9 16.3 23.6 29.7 2.2 82.5 17.3 18.8 60.6 46.1 81.1 7.5 26.6 31.2 7.0 12.9 13.2 16.6 3.6 4.7 6.9 24.7 12.0 17.7 6.6 23.9 50.0 12.0 19.5 11.4 30.0 11.5 11.6 12.3 16.1 15.7 11.2 CTSB ENSG00000164733 "Cathepsin B" P07858 8 11842524-11869448 "Cancer-related genes, Candidate cardiovascular disease genes, Enzymes, Plasma proteins, Predicted secreted proteins" "Hydrolase, Protease, Thiol protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "thyroid gland: 297.0" "Cell line enhanced" "Detected in many" "BJ hTERT+: 237.0;fHDF/TERT166: 137.7" "Cancer enhanced" "Detected in all" "thyroid cancer: 1446.9" "Low region specificity" "Detected in all" "Group enriched" "Detected in all" 4 "basophil: 53.1;classical monocyte: 127.4;intermediate monocyte: 97.0;myeloid DC: 68.0;non-classical monocyte: 54.7;plasmacytoid DC: 95.4" "Group enriched" "Detected in all" 5 "dendritic cells: 95.4;granulocytes: 53.1;monocytes: 127.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB000457, HPA018156, HPA048998" Enhanced Supported Nucleoli,Vesicles "Secreted to blood" 130000000 Vesicles Nucleoli "CAB000457: , HPA018156: AB_1846069, HPA048998: " "unprognostic (5.74e-2)" "unprognostic (4.32e-2)" "unprognostic (1.38e-2)" "unprognostic (2.17e-2)" "unprognostic (2.98e-3)" "unprognostic (5.96e-2)" "unprognostic (1.36e-2)" "unprognostic (1.07e-1)" "unprognostic (2.82e-2)" "unprognostic (1.06e-1)" "unprognostic (7.61e-2)" "unprognostic (8.30e-2)" "unprognostic (2.85e-1)" "unprognostic (7.39e-2)" "unprognostic (4.12e-2)" "prognostic favourable (5.76e-4)" "prognostic unfavourable (9.02e-4)" 227.9 42.1 19.6 67.2 24.4 14.7 67.6 14.9 31.4 76.7 49.1 30.1 22.7 29.9 53.2 44.8 54.2 52.4 43.6 120.7 18.3 23.7 95.6 167.8 94.3 175.1 29.1 16.5 44.2 31.6 13.8 21.6 68.7 24.8 42.6 27.9 33.8 63.7 33.6 41.3 22.8 51.2 51.1 35.9 116.4 26.7 21.5 20.4 18.1 297.0 25.9 38.4 56.8 62.2 7.9 95.4 53.1 127.4 5.3 17.1 108.5 6.4 29.1 3.7 16.0 65.8 74.1 11.6 121.4 237.0 42.5 50.4 13.9 37.9 0.1 17.6 137.7 35.4 5.1 33.5 26.9 3.1 5.0 9.4 3.4 34.1 67.0 2.1 7.0 81.1 45.7 38.4 34.4 83.1 7.8 21.5 35.3 5.1 0.8 3.4 3.1 9.8 3.3 3.8 16.4 12.9 10.1 1.6 9.5 14.0 7.6 63.3 12.3 6.3 115.1 72.3 24.5 23.1 22.6 21.4 15.5 0.5 82.9 8.1 33.8 53.1 127.4 16.3 5.2 97.0 7.2 7.9 17.1 5.8 68.0 6.1 9.6 4.1 18.5 5.3 54.7 95.4 13.4 108.5 19.6 24.4 14.9 28.0 18.3 23.7 29.1 16.5 24.8 20.4 CTSC "DPP1, PALS, PLS" ENSG00000109861 "Cathepsin C" P53634 11 88293592-88337787 "Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Disease mutation, Palmoplantar keratoderma" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "lymphoid tissue: 218.6" "Cell line enhanced" "Detected in all" "BJ hTERT+: 112.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" "CAB025364, HPA066610, HPA068434" Enhanced Supported Vesicles "Intracellular and membrane" 19000000 Vesicles "CAB025364: , HPA066610: , HPA068434: " "unprognostic (4.05e-2)" "unprognostic (1.35e-1)" "unprognostic (1.50e-1)" "unprognostic (1.10e-1)" "unprognostic (3.70e-2)" "unprognostic (1.45e-2)" "prognostic unfavourable (9.30e-5)" "unprognostic (1.62e-1)" "unprognostic (1.04e-1)" "unprognostic (1.56e-2)" "unprognostic (3.11e-2)" "unprognostic (3.35e-1)" "prognostic favourable (4.80e-4)" "unprognostic (2.93e-1)" "unprognostic (4.35e-2)" "unprognostic (8.10e-2)" "unprognostic (4.07e-2)" 40.7 20.5 6.7 44.5 10.6 12.0 35.3 1.5 5.6 14.0 25.3 7.1 6.2 20.4 16.1 24.0 21.8 16.7 36.6 53.3 6.8 6.5 62.7 18.1 110.1 218.6 12.5 3.6 11.0 24.8 3.8 17.3 43.4 9.4 13.8 33.1 27.0 35.1 5.8 10.0 11.7 28.5 14.2 14.6 86.6 13.5 10.8 9.2 19.5 17.7 25.3 30.0 30.2 16.9 8.5 75.9 52.5 92.6 34.7 42.4 31.2 11.2 11.5 4.5 9.4 12.2 33.0 30.2 77.1 112.0 44.0 31.8 31.2 51.8 17.5 41.0 41.8 18.2 7.0 32.6 35.2 30.8 12.7 22.8 31.9 35.1 16.2 28.9 15.4 45.9 23.1 33.9 69.6 43.2 20.7 21.1 5.3 2.1 13.0 40.0 23.6 35.7 17.0 4.7 31.0 56.6 18.9 1.2 9.5 13.0 17.2 10.1 3.8 19.8 21.0 3.0 27.3 20.9 48.9 9.0 12.8 17.7 8.0 61.1 16.7 12.5 32.5 52.5 42.4 69.3 36.5 8.5 19.5 37.8 35.1 4.6 9.9 23.8 37.2 34.7 92.6 75.9 28.4 31.2 6.7 10.6 1.5 5.6 6.8 6.5 12.5 3.6 9.4 9.2 CTSD "CLN10, CPSD" ENSG00000117984 "Cathepsin D" P07339 11 1752752-1764573 "Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins" "Aspartyl protease, Hydrolase, Protease" "Alzheimer disease, Cancer-related genes, Disease mutation, Neurodegeneration, Neuronal ceroid lipofuscinosis" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell line enhanced" "Detected in all" "CAPAN-2: 215.7;SK-BR-3: 206.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "CAB000109, HPA003001" Supported "Secreted to blood" 540000000 "CAB000109: , HPA003001: AB_1078404" "unprognostic (9.95e-2)" "unprognostic (1.62e-1)" "prognostic unfavourable (2.46e-4)" "unprognostic (1.09e-1)" "unprognostic (1.71e-3)" "unprognostic (2.65e-2)" "unprognostic (9.40e-3)" "unprognostic (1.11e-1)" "unprognostic (1.52e-1)" "unprognostic (1.12e-3)" "unprognostic (1.59e-1)" "unprognostic (1.86e-2)" "prognostic favourable (4.93e-5)" "unprognostic (8.98e-2)" "unprognostic (3.39e-2)" "unprognostic (2.13e-2)" "unprognostic (1.60e-1)" 151.9 148.7 21.4 32.8 27.0 83.7 67.7 18.6 47.4 56.3 59.3 41.4 41.9 61.6 25.9 48.2 46.2 34.2 90.0 86.0 25.3 27.6 150.5 163.5 102.6 81.1 49.6 25.7 41.2 62.3 21.3 24.9 56.1 42.8 33.9 33.7 234.4 64.1 42.3 76.2 50.8 90.9 23.3 36.7 87.6 47.0 29.8 29.7 21.1 36.3 42.9 41.4 64.6 43.5 4.9 22.7 51.1 83.8 28.4 26.1 58.7 15.6 42.4 4.9 20.4 62.1 21.2 7.9 11.6 36.2 15.6 18.5 10.5 215.7 3.8 30.1 29.9 84.4 7.1 13.0 4.3 16.1 15.4 5.8 8.0 13.2 65.5 13.3 61.6 34.2 57.0 8.4 15.5 11.4 6.9 23.2 27.6 57.7 3.4 7.5 11.6 17.0 4.9 6.0 14.1 55.0 49.0 6.8 6.7 13.8 206.2 39.1 80.7 18.4 14.3 47.5 7.3 6.5 18.6 32.0 40.1 2.4 69.2 36.1 39.8 29.0 83.8 25.2 26.1 47.6 15.1 4.9 12.2 18.3 22.7 3.2 14.3 18.3 51.1 28.4 38.5 19.2 13.5 58.7 21.4 27.0 18.6 47.4 25.3 27.6 49.6 25.7 42.8 29.7 CTSE ENSG00000196188 "Cathepsin E" P14091 1 206009264-206023909 "Enzymes, Predicted intracellular proteins" "Aspartyl protease, Hydrolase, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "gallbladder: 57.9;intestine: 47.3;stomach 1: 153.0" "Group enriched" "Detected in some" 7 "BEWO: 14.8;RT4: 28.1" "Group enriched" "Detected in many" 8 "lung cancer: 68.8;pancreatic cancer: 297.4;stomach cancer: 200.8" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "HPA012940, CAB032687" Enhanced "Intracellular and membrane" "CAB032687: AB_637901, HPA012940: " "unprognostic (1.17e-2)" "unprognostic (2.45e-1)" "unprognostic (1.31e-2)" "unprognostic (2.72e-2)" "unprognostic (1.35e-2)" "unprognostic (2.52e-3)" "unprognostic (1.45e-1)" "unprognostic (3.29e-2)" "unprognostic (2.87e-2)" "unprognostic (1.20e-2)" "unprognostic (1.39e-1)" "unprognostic (6.37e-3)" "unprognostic (1.42e-1)" "unprognostic (5.45e-2)" "unprognostic (2.61e-2)" "prognostic favourable (5.26e-5)" 0.2 0.1 0.1 3.7 0.1 3.0 0.1 0.1 0.1 0.1 47.3 0.3 0.8 29.3 0.1 0.7 0.6 0.5 57.9 0.3 0.1 0.1 0.2 0.2 24.9 0.0 0.1 0.0 0.1 2.2 0.0 0.5 0.0 0.1 1.3 3.2 0.0 0.1 0.0 0.1 0.1 29.7 0.0 0.1 0.2 153.0 0.1 0.0 0.3 4.2 0.0 1.1 1.8 0.4 0.2 0.7 0.0 0.4 0.0 0.0 0.4 0.2 0.0 0.0 0.0 0.0 0.0 14.8 0.0 0.0 0.0 0.0 0.5 0.6 0.0 2.9 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.4 0.0 1.6 0.0 0.7 2.5 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.5 0.9 0.5 0.0 0.2 0.0 0.5 0.6 28.1 0.1 0.4 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.6 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.4 0.0 0.2 0.0 0.0 0.4 0.1 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.4 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.0 0.1 0.0 CTSF "CATSF, CLN13" ENSG00000174080 "Cathepsin F" Q9UBX1 11 66563463-66568841 "Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Disease mutation, Neurodegeneration, Neuronal ceroid lipofuscinosis" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell line enhanced" "Detected in many" "HSkMC: 28.2;SK-MEL-30: 52.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Group enriched" "Detected in many" 4 "NK-cells: 7.5;T-cells: 9.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB002141, HPA031431, HPA055610" Approved Approved "Vesicles,Plasma membrane,Cytosol" "Intracellular and membrane" 3600000 Cytosol "Vesicles, Plasma membrane" "CAB002141: AB_563471, HPA031431: , HPA055610: " "unprognostic (1.52e-2)" "unprognostic (1.08e-1)" "unprognostic (1.03e-1)" "unprognostic (7.22e-3)" "unprognostic (2.25e-2)" "unprognostic (6.72e-2)" "unprognostic (2.67e-2)" "unprognostic (2.76e-2)" "unprognostic (3.69e-1)" "unprognostic (4.14e-1)" "unprognostic (1.69e-2)" "unprognostic (9.12e-2)" "prognostic favourable (8.92e-7)" "unprognostic (1.36e-2)" "unprognostic (1.28e-1)" "unprognostic (3.89e-1)" "unprognostic (2.42e-1)" 28.1 29.4 24.7 8.0 29.0 1.8 31.1 38.4 47.1 37.3 23.8 32.6 25.2 5.8 38.1 29.8 12.9 34.3 37.3 34.5 25.3 20.5 29.8 45.4 17.3 8.5 28.0 26.0 68.2 23.1 42.6 15.9 20.2 25.4 32.3 8.1 35.0 35.5 37.8 35.8 19.7 9.4 34.6 22.4 10.4 17.8 37.1 30.1 0.8 18.6 14.2 6.3 22.2 21.5 2.1 1.1 0.5 0.7 7.5 9.7 2.4 0.1 9.2 5.0 12.9 21.3 8.6 3.6 6.5 16.5 6.8 4.8 0.0 8.2 0.0 11.0 14.2 0.9 8.5 2.8 3.6 2.2 0.0 0.3 3.8 0.0 11.9 0.1 5.0 28.2 9.6 1.5 1.1 4.3 2.8 1.5 8.5 1.9 0.1 1.1 0.6 3.4 0.0 1.9 1.6 6.1 0.2 6.0 6.4 17.4 2.0 52.3 13.2 0.8 2.8 2.7 2.7 3.2 0.6 8.8 0.1 0.0 6.5 0.1 4.1 0.0 0.7 0.4 6.5 0.7 7.0 2.0 5.6 7.3 0.8 2.1 9.7 5.5 0.5 7.5 0.3 1.1 1.7 2.4 24.7 29.0 38.4 47.1 25.3 20.5 28.0 26.0 25.4 30.1 CTSG CG ENSG00000100448 "Cathepsin G" P08311 14 24573522-24576260 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Antibiotic, Antimicrobial, Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 19 "bone marrow: 450.3" "Cell line enriched" "Detected in some" 7 "THP-1: 437.5" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Group enriched" "Detected in many" 5 "classical monocyte: 6.5;memory CD8 T-cell: 3.5;myeloid DC: 5.1;naive CD8 T-cell: 1.8;neutrophil: 7.1;NK-cell: 5.2;plasmacytoid DC: 5.7" "Low lineage specificity" "Detected in many" "Not detected" "Not detected" "CAB000110, HPA047737" Enhanced "Intracellular and membrane" 67000 "CAB000110: , HPA047737: " "unprognostic (1.67e-1)" "unprognostic (2.57e-2)" "unprognostic (6.92e-2)" "unprognostic (1.08e-1)" "prognostic favourable (1.57e-4)" "unprognostic (4.05e-2)" "unprognostic (4.13e-2)" "unprognostic (3.06e-1)" "unprognostic (2.42e-1)" "unprognostic (2.60e-2)" "unprognostic (2.05e-2)" "unprognostic (1.63e-3)" "unprognostic (1.07e-2)" "unprognostic (1.09e-1)" "unprognostic (1.37e-1)" "prognostic unfavourable (8.91e-4)" 15.1 0.5 0.0 6.0 0.0 450.3 6.0 0.0 0.6 10.0 5.1 0.0 2.8 1.1 6.2 19.7 6.4 0.8 16.7 23.4 0.0 0.0 2.1 2.0 9.2 3.7 0.0 0.0 1.5 3.4 0.8 0.5 3.0 0.0 8.2 3.2 2.6 6.3 6.9 1.1 19.5 8.9 14.9 0.0 10.7 3.2 2.8 0.0 15.6 0.5 12.0 5.1 2.9 3.3 0.0 5.7 7.1 6.5 5.2 3.5 12.9 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 15.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 437.5 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.0 64.9 0.0 0.0 6.5 0.0 1.1 1.0 0.0 0.0 1.0 3.5 5.1 0.0 0.0 1.8 7.1 5.2 0.0 5.7 0.0 12.9 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 CTSH "ACC-4, ACC-5, ACC4, ACC5, CPSB" ENSG00000103811 "Cathepsin H" P09668 15 78921058-78949574 "Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "lung: 82.6" "Cell line enhanced" "Detected in many" "CAPAN-2: 42.5;HaCaT: 31.0;RT4: 118.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Cell type enhanced" "Detected in many" "classical monocyte: 42.8" "Group enriched" "Detected in all" 5 "B-cells: 20.6;dendritic cells: 41.2;monocytes: 42.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" "CAB000458, HPA003524" Enhanced Supported "Vesicles,Cytosol,Cytoplasmic bodies" "Intracellular and membrane" 10000000 "Vesicles, Cytosol, Cytoplasmic bodies" "CAB000458: , HPA003524: AB_1846075" "unprognostic (6.47e-2)" "unprognostic (4.65e-3)" "unprognostic (1.05e-1)" "prognostic favourable (6.90e-4)" "unprognostic (4.37e-2)" "unprognostic (1.93e-1)" "unprognostic (7.18e-2)" "unprognostic (3.30e-3)" "unprognostic (2.22e-1)" "unprognostic (5.96e-2)" "unprognostic (4.10e-2)" "unprognostic (3.89e-2)" "unprognostic (6.63e-3)" "unprognostic (3.83e-1)" "unprognostic (4.42e-2)" "unprognostic (2.70e-3)" "unprognostic (1.79e-3)" 16.7 10.6 9.5 24.2 7.0 5.4 23.9 4.5 9.8 25.1 11.4 17.7 14.7 10.6 10.3 17.1 7.8 13.1 29.2 16.5 14.8 6.7 66.7 18.7 82.6 65.4 12.1 11.6 14.6 25.8 12.3 6.5 7.7 9.4 18.6 6.6 6.7 15.4 15.9 7.0 13.5 16.6 9.8 10.8 20.3 15.6 6.7 15.7 6.6 8.5 4.8 34.8 39.6 13.5 20.6 41.2 1.4 42.8 1.3 7.6 27.3 16.0 1.1 0.4 4.7 1.1 0.0 5.2 1.6 0.6 2.8 1.5 7.0 42.5 5.6 1.7 0.1 31.0 2.0 7.7 2.3 23.6 0.1 0.1 0.2 16.2 1.6 0.0 1.0 0.8 2.2 0.0 0.0 0.2 11.4 0.0 3.8 1.7 3.6 9.8 1.2 0.3 0.0 0.3 0.9 9.8 118.0 0.5 1.1 6.9 3.9 9.6 1.5 5.3 2.2 0.0 1.0 0.0 0.7 0.1 12.2 3.1 0.0 10.3 1.7 0.0 42.8 0.4 1.4 28.3 7.6 20.6 4.1 2.1 41.2 12.0 0.4 0.7 1.4 1.3 17.0 4.2 3.1 27.3 9.5 7.0 4.5 9.8 14.8 6.7 12.1 11.6 9.4 15.7 CTSK "CTSO, CTSO2, PKND, PYCD" ENSG00000143387 "Cathepsin K" P43235 1 150796208-150808323 "Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Protease, Thiol protease" "Disease mutation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "adipose tissue: 104.1" "Group enriched" "Detected in some" 8 "ASC diff: 200.2;ASC TERT1: 73.3;BJ hTERT+: 161.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Cell type enhanced" "Detected in many" "classical monocyte: 6.7" "Lineage enriched" "Detected in many" 6 "monocytes: 6.7" "Low region specificity" "Detected in all" HPA050346 Supported Vesicles "Intracellular and membrane" Vesicles "HPA050346: " "unprognostic (1.48e-1)" "unprognostic (9.29e-2)" "unprognostic (1.21e-1)" "unprognostic (7.61e-3)" "unprognostic (5.08e-2)" "unprognostic (6.57e-2)" "unprognostic (1.02e-1)" "unprognostic (6.60e-2)" "unprognostic (2.11e-1)" "unprognostic (1.01e-1)" "unprognostic (1.49e-1)" "unprognostic (3.54e-2)" "prognostic unfavourable (7.12e-5)" "unprognostic (6.07e-3)" "unprognostic (2.98e-2)" "unprognostic (5.93e-3)" "unprognostic (6.41e-2)" 104.1 2.4 1.2 6.5 1.6 1.3 79.3 2.4 2.3 70.6 23.6 2.2 10.1 2.7 72.5 25.9 26.5 12.5 53.4 14.7 1.1 1.1 3.4 1.8 8.7 10.4 1.1 1.7 25.4 2.9 0.3 3.0 30.6 2.6 24.2 11.5 56.0 10.9 6.8 19.9 44.0 11.0 26.9 2.0 5.6 8.6 24.1 0.9 1.1 7.1 13.2 10.7 38.0 48.2 0.1 1.0 1.0 6.7 0.5 1.2 1.8 0.1 0.1 0.3 0.3 200.2 73.3 0.2 5.7 161.8 0.4 0.8 0.0 0.1 0.1 0.2 11.1 0.2 0.0 0.1 0.2 0.1 0.1 0.3 0.1 0.0 1.0 0.1 0.4 14.6 0.5 4.5 0.1 0.6 0.0 0.5 0.4 0.3 0.0 0.7 1.1 0.1 0.0 0.1 0.0 0.4 0.1 0.1 0.6 0.3 0.0 3.0 0.2 0.2 0.4 0.2 0.1 0.2 0.2 0.6 0.5 1.1 17.0 0.0 0.9 0.0 6.7 1.0 0.7 3.4 0.2 0.0 0.6 0.2 0.4 0.1 0.3 0.5 0.6 0.5 2.0 1.0 1.2 1.8 1.2 1.6 2.4 2.3 1.1 1.1 1.1 1.7 2.6 0.9 CTSL "CTSL1, FLJ31037" ENSG00000135047 "Cathepsin L" P07711 9 87725519-87731393 "Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "placenta: 237.0" "Cell line enhanced" "Detected in many" "ASC TERT1: 198.5;HSkMC: 91.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 9 "intermediate monocyte: 31.0;non-classical monocyte: 44.3" "Lineage enriched" "Detected in many" 10 "monocytes: 44.3" "CAB000459, HPA070413" Enhanced Approved "Golgi apparatus,Vesicles" "Intracellular and membrane" 17000000 "Golgi apparatus" Vesicles "CAB000459: AB_2292484, HPA070413: " "unprognostic (1.05e-1)" "unprognostic (1.01e-1)" "unprognostic (1.24e-2)" "unprognostic (1.53e-1)" "prognostic unfavourable (3.73e-4)" "unprognostic (1.19e-3)" "unprognostic (8.12e-3)" "prognostic unfavourable (5.15e-5)" "unprognostic (2.09e-1)" "unprognostic (3.15e-1)" "unprognostic (6.80e-2)" "unprognostic (3.21e-1)" "prognostic favourable (4.34e-4)" "unprognostic (5.64e-3)" "unprognostic (2.26e-2)" "unprognostic (1.72e-1)" "unprognostic (7.11e-3)" 60.3 21.5 10.4 27.2 24.6 18.4 23.3 6.9 12.3 14.8 23.2 14.1 13.7 9.0 24.1 22.3 11.4 25.7 20.7 37.7 10.7 11.4 65.4 98.0 53.1 80.5 18.9 7.7 25.0 14.3 18.8 18.0 237.0 18.4 19.4 13.0 23.2 22.0 23.5 29.3 9.1 12.0 36.6 16.1 108.1 17.5 14.1 15.7 6.8 19.2 9.4 10.1 41.3 26.5 0.0 1.7 0.1 44.3 0.0 4.3 2.4 6.3 36.8 2.5 4.3 46.3 198.5 15.4 20.5 59.7 17.6 22.1 3.5 5.9 0.0 9.6 26.5 5.4 3.3 6.6 14.5 0.1 3.2 1.1 10.4 8.6 30.0 0.0 4.4 91.8 11.2 28.8 11.2 13.8 11.9 0.0 25.3 10.6 0.0 0.7 4.9 7.0 1.5 1.5 0.0 12.3 3.3 3.7 4.5 4.3 9.6 23.5 1.1 7.3 21.7 15.8 8.6 57.5 8.6 1.6 5.9 0.0 57.8 0.0 5.2 0.1 3.5 0.1 0.0 31.0 0.0 0.0 1.8 0.0 1.7 0.0 4.3 0.3 0.1 0.0 44.3 0.1 0.3 2.4 10.4 24.6 6.9 11.7 10.7 11.4 18.9 7.7 18.4 15.7 CTSO CTSO1 ENSG00000256043 "Cathepsin O" P43234 4 155924118-155953917 "Enzymes, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell line enhanced" "Detected in many" "ASC TERT1: 12.3;HSkMC: 14.6;Karpas-707: 27.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA002041 Approved "Intracellular and membrane" 24000 "HPA002041: AB_1078408" "unprognostic (3.96e-3)" "unprognostic (1.62e-2)" "unprognostic (1.03e-1)" "unprognostic (1.33e-2)" "unprognostic (9.10e-3)" "unprognostic (2.55e-1)" "unprognostic (3.80e-3)" "unprognostic (2.07e-1)" "unprognostic (6.62e-2)" "unprognostic (1.33e-1)" "unprognostic (2.20e-1)" "unprognostic (1.05e-1)" "unprognostic (7.55e-2)" "unprognostic (4.87e-3)" "unprognostic (4.73e-2)" "unprognostic (1.11e-1)" "unprognostic (1.79e-1)" 13.7 16.4 11.9 12.6 12.0 1.8 14.9 3.7 12.4 16.0 18.5 11.6 10.2 13.3 19.3 27.3 10.8 15.6 16.9 19.7 9.7 8.6 21.2 41.6 26.4 19.4 10.2 6.7 16.3 10.7 13.6 9.4 18.7 9.7 16.1 9.8 24.0 13.8 16.8 5.9 6.2 27.5 14.4 11.4 19.3 10.8 9.0 7.7 5.5 17.1 10.2 10.3 12.4 12.5 7.0 8.9 5.3 14.8 12.0 10.9 8.9 0.3 0.2 1.5 1.6 5.6 12.3 0.0 3.5 7.1 1.3 1.8 0.0 4.6 0.0 0.7 2.3 0.0 0.0 0.3 0.9 5.2 0.1 0.4 0.0 0.0 5.9 0.7 0.1 14.6 1.3 0.8 0.6 1.2 0.0 27.5 4.1 0.3 0.3 0.1 0.3 0.2 1.6 0.3 1.7 5.3 2.3 0.2 1.7 0.8 2.9 1.0 1.5 1.0 2.0 4.3 0.2 0.4 1.1 3.1 0.0 0.0 7.8 0.0 5.8 5.3 12.0 0.8 7.9 14.8 10.9 5.8 6.1 7.3 8.9 7.0 6.7 6.8 0.5 12.0 10.7 8.3 6.8 8.9 11.9 12.0 3.7 12.4 9.7 8.6 10.2 6.7 9.7 7.7 CTSS ENSG00000163131 "Cathepsin S" P25774 1 150730196-150765957 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "blood: 171.4;lymphoid tissue: 111.4" "Cell line enhanced" "Detected in many" "CAPAN-2: 21.1;HMC-1: 50.3;U-698: 106.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in all" 7 "classical monocyte: 171.4;intermediate monocyte: 151.2;myeloid DC: 43.5;neutrophil: 94.5;non-classical monocyte: 138.5" "Group enriched" "Detected in all" 9 "dendritic cells: 43.5;granulocytes: 94.5;monocytes: 171.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB000460, HPA002988" Supported Approved Vesicles "Intracellular and membrane" 19000000 Vesicles "CAB000460: , HPA002988: AB_1078409" "unprognostic (7.81e-2)" "unprognostic (9.04e-2)" "unprognostic (3.23e-2)" "unprognostic (3.93e-2)" "unprognostic (1.52e-1)" "unprognostic (1.12e-2)" "unprognostic (1.11e-1)" "unprognostic (1.23e-1)" "unprognostic (1.59e-1)" "unprognostic (6.00e-3)" "unprognostic (1.46e-1)" "unprognostic (3.89e-1)" "unprognostic (6.24e-2)" "unprognostic (7.50e-2)" "unprognostic (4.14e-2)" "unprognostic (2.13e-1)" "unprognostic (2.47e-3)" 41.6 9.3 6.8 32.3 10.3 30.3 9.7 1.9 6.2 4.7 32.9 6.6 5.6 19.6 3.7 12.9 8.8 10.7 15.9 17.3 6.4 5.1 9.6 21.5 55.8 99.5 12.6 2.3 7.6 6.4 0.4 3.4 14.4 9.3 7.5 33.4 6.5 12.9 3.3 3.5 3.8 38.0 6.8 17.1 111.4 13.8 3.8 9.5 12.9 7.6 4.6 22.8 21.5 5.3 11.1 43.5 94.5 171.4 3.3 5.6 145.4 1.0 3.2 0.0 0.0 0.4 0.3 0.3 0.0 3.2 0.2 0.6 0.0 21.1 14.5 1.6 0.1 0.4 0.0 0.1 0.0 8.1 0.0 6.4 0.1 0.0 0.0 8.7 50.3 0.6 0.0 1.8 0.1 1.2 0.6 12.7 0.4 0.0 0.0 6.2 0.0 0.0 3.6 1.2 17.8 3.9 3.1 0.0 0.1 0.2 0.9 0.3 0.0 17.8 1.7 1.3 0.2 0.0 0.2 8.8 0.8 106.9 7.4 9.4 0.8 1.2 171.4 16.5 3.2 151.2 3.9 11.1 3.9 3.8 43.5 10.2 3.9 3.6 94.5 3.3 138.5 9.4 5.6 145.4 6.8 10.3 1.9 6.2 6.4 5.1 12.6 2.3 9.3 9.5 CTSV "CTSL2, CTSU" ENSG00000136943 "Cathepsin V" O60911 9 97029679-97039643 "Enzymes, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 5 "lymphoid tissue: 154.7" "Cell line enriched" "Detected in many" 8 "BEWO: 113.4" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Group enriched" "Detected in some" 6 "NK-cell: 4.2;plasmacytoid DC: 15.7" "Group enriched" "Detected in many" 42 "dendritic cells: 15.7;NK-cells: 4.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" CAB017112 Uncertain Approved "Nucleoplasm,Nucleoli fibrillar center,Plasma membrane,Cytosol" "Intracellular and membrane" 260000 "Nucleoli fibrillar center, Cytosol" "Nucleoplasm, Plasma membrane" "CAB017112: " "unprognostic (2.40e-1)" "unprognostic (2.74e-2)" "unprognostic (1.50e-1)" "prognostic favourable (8.41e-4)" "unprognostic (7.29e-2)" "unprognostic (5.59e-2)" "prognostic unfavourable (2.83e-5)" "unprognostic (7.04e-3)" "unprognostic (6.06e-2)" "unprognostic (1.39e-2)" "prognostic unfavourable (2.87e-4)" "unprognostic (1.86e-2)" "unprognostic (1.78e-1)" "unprognostic (2.41e-2)" "unprognostic (1.33e-1)" "unprognostic (3.04e-3)" "prognostic unfavourable (2.39e-4)" 0.7 0.0 0.4 0.6 0.7 0.0 3.5 0.4 1.0 23.0 1.4 2.0 0.4 0.5 1.5 1.5 9.8 0.6 0.5 0.2 0.8 0.6 9.7 0.4 0.6 0.2 1.5 0.7 0.4 1.1 1.1 0.9 8.7 1.6 0.5 1.6 4.3 5.0 0.6 0.5 25.0 0.6 0.2 3.0 0.2 1.1 32.4 1.0 154.7 0.7 6.3 2.7 0.2 9.9 0.2 15.7 0.2 0.0 4.2 0.0 0.1 7.3 2.2 2.5 6.5 0.1 0.0 113.4 0.0 0.0 1.6 1.3 14.9 7.3 0.1 0.6 0.1 14.0 12.1 8.9 2.3 0.0 1.6 0.3 0.7 2.3 0.0 0.0 1.0 0.0 3.0 0.4 0.3 0.5 0.2 0.0 2.9 2.7 0.2 0.1 15.0 2.1 0.0 5.4 0.1 2.2 0.9 0.6 1.1 7.4 2.6 2.6 4.6 0.8 0.0 0.4 7.4 0.1 0.8 1.5 4.0 0.1 0.4 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.7 0.2 0.0 0.0 0.2 4.2 0.0 15.7 0.0 0.1 0.4 0.7 0.4 1.0 0.8 0.6 1.5 0.7 1.6 1.0 CTSW ENSG00000172543 "Cathepsin W" P56202 11 65879809-65883741 "Enzymes, Plasma proteins, Predicted secreted proteins" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "blood: 157.2;bone marrow: 41.4" "Group enriched" "Detected in some" 23 "HEL: 37.9;NB-4: 86.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Group enriched" "Detected in many" 8 "gdT-cell: 106.6;MAIT T-cell: 67.7;memory CD8 T-cell: 68.3;naive CD8 T-cell: 51.4;NK-cell: 157.2" "Group enriched" "Detected in many" 48 "NK-cells: 157.2;T-cells: 106.6" "Low region specificity" "Detected in single" "Low region specificity" "Detected in all" CAB016345 Enhanced "Secreted to blood" 340000 "CAB016345: AB_626813" "prognostic favourable (3.06e-4)" "unprognostic (2.06e-2)" "unprognostic (2.71e-2)" "prognostic favourable (8.36e-6)" "unprognostic (1.21e-1)" "prognostic favourable (9.89e-4)" "unprognostic (5.69e-2)" "unprognostic (1.09e-2)" "unprognostic (1.25e-3)" "unprognostic (5.14e-3)" "unprognostic (2.83e-2)" "unprognostic (1.59e-1)" "prognostic unfavourable (8.84e-6)" "unprognostic (3.86e-2)" "unprognostic (3.78e-1)" "unprognostic (1.26e-1)" "unprognostic (4.01e-3)" 5.2 1.2 0.9 4.9 1.0 41.4 2.3 0.6 0.7 3.9 4.9 0.8 0.5 2.4 8.4 4.0 2.1 2.1 2.5 9.0 0.9 1.0 2.5 6.8 12.7 36.0 1.1 0.6 3.0 1.1 0.0 1.4 10.7 1.4 7.4 2.5 6.3 10.9 1.5 1.9 1.5 5.9 1.7 2.1 33.1 3.3 3.4 0.4 11.1 3.1 1.3 18.2 4.5 2.6 0.4 2.7 2.3 0.3 157.2 106.6 45.7 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 37.9 0.0 0.0 0.0 2.7 0.1 0.0 0.0 0.0 0.0 0.0 0.0 2.2 0.0 0.0 0.4 86.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 1.3 0.0 0.0 0.0 0.1 0.2 0.0 0.1 0.0 0.0 2.3 0.0 2.3 0.2 0.3 106.6 0.2 67.7 0.4 11.7 68.3 2.7 0.3 7.0 51.4 2.0 157.2 0.3 1.7 1.6 45.7 0.9 1.0 0.6 0.7 0.9 1.0 1.1 0.6 1.4 0.4 CTSZ CTSX ENSG00000101160 "Cathepsin Z" Q9UBR2 20 58995185-59007247 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell line enhanced" "Detected in many" "fHDF/TERT166: 118.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 4 "classical monocyte: 3.2;intermediate monocyte: 2.7;memory B-cell: 1.0;myeloid DC: 3.9;naive B-cell: 1.9;neutrophil: 3.5;non-classical monocyte: 2.9;plasmacytoid DC: 2.2" "Low lineage specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" "CAB025114, HPA049876, HPA053504" Supported Supported Vesicles "Intracellular and membrane" 85000000 Vesicles "CAB025114: , HPA049876: , HPA053504: " "unprognostic (7.30e-2)" "unprognostic (3.98e-2)" "unprognostic (4.07e-2)" "unprognostic (1.11e-3)" "unprognostic (8.25e-3)" "unprognostic (1.15e-1)" "unprognostic (4.12e-2)" "unprognostic (6.59e-2)" "unprognostic (1.59e-1)" "unprognostic (1.22e-1)" "unprognostic (1.33e-1)" "unprognostic (5.33e-2)" "prognostic unfavourable (5.72e-5)" "unprognostic (1.96e-1)" "unprognostic (6.92e-2)" "unprognostic (1.19e-1)" "unprognostic (2.04e-1)" 70.7 27.9 12.4 40.8 20.4 20.7 51.2 14.6 13.5 25.4 52.8 16.0 19.9 40.8 20.6 25.5 20.1 20.7 22.3 50.1 9.8 13.3 34.9 83.7 54.3 61.2 18.8 10.5 29.7 29.0 30.6 27.6 38.6 19.2 28.8 37.8 31.5 40.3 17.7 20.7 12.9 63.6 26.4 22.1 56.5 19.2 13.8 14.9 18.4 42.4 17.5 35.8 29.8 21.5 1.9 3.9 3.5 3.2 0.3 0.6 0.8 27.2 21.2 0.0 0.0 25.0 28.8 15.0 44.9 49.7 34.4 30.8 41.0 45.9 15.0 29.7 118.0 21.8 13.5 42.5 23.6 47.9 1.8 13.7 34.4 0.0 26.2 1.6 47.7 24.5 25.7 15.0 18.0 54.4 9.9 7.6 23.0 0.0 0.1 14.8 1.7 21.2 0.3 0.1 18.0 25.1 6.4 0.4 0.3 34.9 40.4 0.1 18.7 23.2 59.8 0.0 23.2 30.2 0.2 36.2 22.0 2.8 0.4 33.1 0.0 0.0 3.2 0.3 0.6 2.7 0.0 1.0 0.4 0.1 3.9 1.9 0.4 0.1 3.5 0.3 2.9 2.2 0.2 0.8 12.4 20.4 14.6 13.5 9.8 13.3 18.8 10.5 19.2 14.9 CYLD "CYLD1, KIAA0849, USPL2" ENSG00000083799 "CYLD lysine 63 deubiquitinase" Q9NQC7 16 50742050-50801935 "Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" "Cell cycle, Immunity, Innate immunity, Ubl conjugation pathway, Wnt signaling pathway" "Hydrolase, Protease, Thiol protease" "Cancer-related genes, Disease mutation, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HDLM-2: 46.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB011713, HPA050095" Approved Supported "Nucleoplasm,Centriolar satellite" "Centriolar satellite" Nucleoplasm "CAB011713: AB_731794, HPA050095: " "unprognostic (9.83e-2)" "unprognostic (1.17e-2)" "unprognostic (5.01e-2)" "unprognostic (2.83e-2)" "unprognostic (3.84e-1)" "unprognostic (5.06e-2)" "unprognostic (3.87e-2)" "unprognostic (3.24e-2)" "unprognostic (9.46e-2)" "unprognostic (1.11e-1)" "unprognostic (1.18e-2)" "unprognostic (2.32e-1)" "unprognostic (1.03e-1)" "unprognostic (1.07e-1)" "unprognostic (3.43e-2)" "unprognostic (6.83e-2)" "unprognostic (8.42e-2)" 9.3 16.2 13.9 22.9 26.4 51.1 9.1 14.2 20.9 9.2 10.3 18.8 12.8 10.2 16.1 8.1 15.3 8.5 13.3 12.7 15.7 17.0 9.4 13.2 15.6 30.7 16.3 14.3 11.5 12.2 20.3 27.8 9.8 20.0 11.0 12.7 13.3 12.6 10.9 31.7 12.4 14.2 12.5 16.3 23.4 12.4 22.6 13.7 16.9 16.2 8.0 29.3 14.1 12.6 9.2 10.2 31.4 9.8 13.6 19.1 10.2 9.1 2.9 3.3 3.7 5.3 7.7 3.0 13.6 19.9 14.2 8.4 2.4 4.3 10.6 4.9 13.2 3.6 3.9 8.2 21.1 46.4 6.0 5.3 5.1 1.9 10.6 5.2 24.9 8.4 6.7 17.1 17.9 5.7 2.2 9.2 19.8 1.3 5.1 7.6 3.5 4.8 4.6 6.8 10.1 4.6 3.2 4.3 3.3 11.5 3.9 3.3 3.9 6.6 6.4 24.3 5.5 8.5 5.5 24.3 23.1 11.8 17.8 5.9 5.1 31.4 8.6 20.8 10.7 9.8 12.9 9.2 15.8 14.4 10.2 6.2 14.7 11.4 19.4 13.6 9.5 6.2 19.1 10.2 13.9 26.4 14.2 20.9 15.7 17.0 16.3 14.3 20.0 13.7 DNPEP "ASPEP, DAP" ENSG00000123992 "Aspartyl aminopeptidase" Q9ULA0 2 219373527-219400022 "Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Aminopeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA036398, HPA044860" Enhanced Supported Cytosol 6200000 Cytosol "HPA036398: AB_10970915, HPA044860: AB_10961275" "unprognostic (3.71e-1)" "unprognostic (6.45e-2)" "unprognostic (1.26e-1)" "unprognostic (1.05e-2)" "unprognostic (1.55e-2)" "unprognostic (2.75e-1)" "unprognostic (2.54e-3)" "unprognostic (3.34e-2)" "unprognostic (2.44e-1)" "unprognostic (3.49e-2)" "unprognostic (1.61e-1)" "unprognostic (6.13e-2)" "unprognostic (1.67e-1)" "unprognostic (5.63e-3)" "unprognostic (3.49e-1)" "unprognostic (2.50e-1)" "unprognostic (1.85e-3)" 20.1 12.3 8.8 15.5 10.4 7.2 20.0 7.2 9.3 16.5 30.4 8.6 13.8 27.9 15.1 13.3 16.9 15.3 16.6 22.9 10.4 6.8 21.2 33.5 15.5 11.7 10.5 7.2 19.4 19.0 9.7 11.0 28.5 9.4 21.0 15.8 15.9 18.7 14.7 36.6 14.6 50.3 12.9 6.8 17.5 15.2 33.7 9.3 11.3 15.0 20.0 17.4 20.7 13.1 11.6 16.1 5.8 15.0 15.7 15.7 10.9 16.0 8.8 5.4 16.1 14.4 11.9 43.0 8.0 16.2 20.9 22.1 24.3 21.2 9.8 17.3 16.6 15.8 6.5 18.3 7.6 19.2 4.6 15.9 9.0 26.4 38.2 13.1 11.4 19.3 19.5 21.5 18.0 14.3 17.9 15.8 10.7 34.9 20.0 14.6 8.9 5.5 26.0 12.4 12.9 11.6 25.0 6.8 9.2 9.3 30.8 11.3 9.0 14.5 7.9 20.1 16.6 10.5 11.5 17.7 10.3 7.0 28.6 12.6 8.5 5.8 13.2 5.4 13.6 15.0 15.4 10.2 11.0 15.0 16.1 11.6 12.0 15.7 1.0 15.7 12.2 5.8 12.6 10.9 8.8 10.4 7.2 9.3 10.4 6.8 10.5 7.2 9.4 9.3 DPP10 "DPL2, DPPY, DPRP3" ENSG00000175497 "Dipeptidyl peptidase like 10" Q8N608 2 114442299-115845752 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters" Asthma "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 5 "adrenal gland: 15.6;brain: 30.3;pancreas: 23.4" "Cell line enhanced" "Detected in some" "AF22: 5.0;HAP1: 7.5;HMC-1: 5.3;NTERA-2: 4.5;RT4: 8.0;SCLC-21H: 11.9;SH-SY5Y: 4.8" "Low cancer specificity" "Detected in some" "Low region specificity" "Detected in all" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA048767 Uncertain "HPA048767: " "unprognostic (1.19e-1)" "unprognostic (2.55e-2)" "unprognostic (1.84e-1)" "unprognostic (1.77e-2)" "unprognostic (1.29e-1)" "unprognostic (2.03e-2)" "unprognostic (6.59e-2)" "unprognostic (2.92e-1)" "unprognostic (5.35e-2)" "unprognostic (2.95e-2)" "unprognostic (1.23e-1)" "unprognostic (1.03e-2)" "unprognostic (8.33e-2)" "unprognostic (7.61e-2)" "unprognostic (4.22e-2)" 0.7 15.6 13.4 1.1 15.9 0.9 0.9 1.9 30.3 1.3 3.6 7.9 0.0 2.4 1.4 0.8 0.8 0.9 1.9 0.8 17.5 9.9 1.1 0.9 1.0 0.7 7.1 21.3 0.9 23.4 0.7 1.5 1.8 10.8 0.8 4.6 0.0 1.0 0.8 0.7 0.9 2.4 1.9 12.7 0.7 1.5 2.1 10.3 0.0 1.6 0.0 0.8 0.7 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 7.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.3 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 4.5 0.0 0.0 0.0 0.0 0.0 8.0 11.9 4.8 0.0 0.0 0.0 0.0 0.5 0.0 0.0 1.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 13.4 15.9 1.9 30.3 17.5 9.9 7.1 21.3 10.8 10.3 DPP3 ENSG00000254986 "Dipeptidyl peptidase 3" Q9NY33 11 66480013-66509657 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Aminopeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA035780, HPA035781" Approved Supported Cytosol 2600000 Cytosol "HPA035780: AB_2674778, HPA035781: AB_10669529" "unprognostic (5.74e-2)" "unprognostic (1.16e-3)" "unprognostic (2.62e-3)" "unprognostic (4.77e-2)" "unprognostic (1.99e-1)" "unprognostic (5.44e-3)" "unprognostic (1.67e-3)" "unprognostic (1.25e-3)" "unprognostic (1.73e-2)" "unprognostic (9.87e-2)" "unprognostic (1.02e-2)" "unprognostic (3.87e-1)" "unprognostic (5.85e-2)" "prognostic favourable (1.34e-4)" "unprognostic (1.81e-2)" "unprognostic (3.43e-1)" "unprognostic (5.66e-2)" 10.4 13.0 5.2 16.8 12.1 10.9 16.9 13.7 11.5 7.3 18.5 9.1 10.3 15.3 10.5 6.8 15.6 7.1 15.7 8.4 9.3 5.9 18.4 31.1 9.8 20.0 9.5 10.6 5.1 11.6 11.2 6.9 10.9 7.4 10.3 16.9 5.7 17.6 8.5 15.8 9.4 15.5 10.0 10.6 12.5 11.8 15.5 6.7 16.1 10.5 10.8 14.0 11.4 8.6 7.5 19.7 12.2 24.4 18.2 17.9 9.9 28.5 24.8 11.5 12.8 9.6 10.4 17.9 16.2 21.8 21.9 14.6 31.2 24.0 16.6 55.2 18.3 25.7 18.3 19.8 14.1 31.5 8.3 21.6 11.6 18.3 14.8 26.1 36.1 14.7 19.4 16.4 8.2 16.7 15.1 9.9 19.9 32.4 30.4 26.6 19.6 15.2 21.5 11.6 27.2 18.8 24.6 21.8 18.7 13.8 16.1 21.6 25.0 15.3 17.4 13.1 14.3 14.4 15.8 8.3 15.1 18.9 17.4 12.5 16.1 9.6 11.3 12.2 13.7 24.4 8.4 7.5 10.3 11.4 19.7 7.2 6.3 9.2 2.0 18.2 16.0 13.7 17.9 9.9 5.2 12.1 13.7 11.5 9.3 5.9 9.5 10.6 7.4 6.7 DPP4 "ADCP2, CD26, DPPIV" ENSG00000197635 "Dipeptidyl peptidase 4" P27487 2 161992241-162074542 "CD markers, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins" "Cell adhesion" "Aminopeptidase, Hydrolase, Protease, Receptor, Serine protease" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 133.1;parathyroid gland: 75.5" "Cell line enhanced" "Detected in some" "ASC diff: 41.8;ASC TERT1: 42.4;BJ hTERT+: 38.9;RPTEC TERT1: 56.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in single" "Cell type enhanced" "Detected in many" "MAIT T-cell: 26.7" "Lineage enriched" "Detected in many" 10 "T-cells: 26.7" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" CAB045970 Enhanced "Secreted in other tissues" 170000000 "CAB045970: AB_11140529" "unprognostic (4.47e-2)" "unprognostic (4.47e-2)" "unprognostic (8.89e-2)" "unprognostic (3.36e-1)" "unprognostic (7.25e-2)" "unprognostic (5.40e-2)" "unprognostic (2.78e-1)" "unprognostic (3.54e-2)" "unprognostic (3.58e-1)" "unprognostic (4.73e-1)" "unprognostic (2.36e-1)" "prognostic unfavourable (1.98e-4)" "prognostic favourable (1.35e-6)" "unprognostic (4.68e-2)" "unprognostic (6.33e-2)" "prognostic favourable (4.99e-4)" "unprognostic (1.21e-2)" 9.5 2.9 0.3 3.2 0.5 0.0 5.0 0.3 1.4 2.2 50.0 0.2 36.9 19.1 2.2 3.5 1.2 1.2 5.2 2.1 0.4 0.3 29.1 12.2 5.4 2.1 0.4 0.2 2.7 1.8 75.5 0.3 24.0 0.2 21.1 2.8 0.6 46.9 38.8 2.4 4.4 133.1 0.9 0.8 5.0 1.2 0.6 0.1 6.2 1.0 1.4 1.1 1.0 2.6 0.1 2.1 0.3 0.0 2.6 26.7 2.5 0.0 0.0 0.1 0.0 41.8 42.4 0.1 7.7 38.9 2.1 7.6 7.8 0.2 0.0 2.9 13.4 0.2 0.1 0.0 1.3 2.4 0.1 0.0 0.0 11.7 17.1 0.0 0.0 4.8 0.0 13.1 0.1 1.2 0.0 0.0 0.7 0.0 0.7 0.1 0.4 16.0 0.0 0.0 0.1 56.7 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 6.9 4.5 0.2 0.2 0.0 0.0 0.0 0.0 4.6 0.0 0.0 0.0 0.0 0.0 3.2 0.0 26.7 0.1 8.3 5.2 0.6 0.0 8.3 3.3 0.3 2.6 0.0 2.1 0.9 2.5 0.3 0.5 0.3 1.4 0.4 0.3 0.4 0.2 0.2 0.1 DPP6 "DPL1, DPPX" ENSG00000130226 "Dipeptidyl peptidase like 6" P42658 7 153887097-154894285 "Disease related genes, Enzymes, Potential drug targets, Predicted membrane proteins, Transporters" "Disease mutation, Mental retardation, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 45.7;endometrium 1: 24.5;thyroid gland: 24.1" "Cell line enriched" "Detected in some" 9 "NTERA-2: 11.0" "Cancer enriched" "Detected in some" 11 "glioma: 12.1" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in some" "Low lineage specificity" "Detected in single" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA050509 Enhanced Supported "HPA050509: " "unprognostic (1.29e-1)" "unprognostic (3.55e-2)" "unprognostic (5.68e-2)" "unprognostic (5.86e-2)" "unprognostic (1.53e-2)" "unprognostic (2.28e-1)" "unprognostic (2.73e-1)" "unprognostic (5.83e-4)" "unprognostic (1.55e-1)" "unprognostic (2.98e-1)" "unprognostic (7.45e-3)" "unprognostic (4.04e-3)" "unprognostic (2.94e-3)" "unprognostic (1.85e-4)" "unprognostic (1.05e-1)" "unprognostic (4.61e-3)" "unprognostic (6.11e-2)" 1.6 7.2 15.4 1.4 32.5 1.3 1.5 26.6 45.7 2.3 6.8 8.7 0.0 1.6 24.5 3.1 1.5 4.6 1.3 1.4 26.6 15.2 3.6 1.2 2.2 1.3 14.0 22.7 1.3 4.0 1.2 4.9 1.3 18.8 1.5 2.4 0.4 1.3 8.1 4.6 3.7 2.0 15.8 7.2 4.2 3.5 7.9 10.0 0.0 24.1 0.0 1.2 1.3 0.4 0.6 0.6 1.9 0.9 0.9 0.7 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.3 0.2 11.0 0.0 0.0 0.0 0.1 0.0 0.0 0.5 1.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.3 0.0 0.1 1.9 0.4 0.7 0.4 0.6 0.7 0.6 0.6 0.4 0.4 0.6 0.7 0.7 1.6 0.9 0.9 0.6 0.5 0.3 15.4 32.5 26.6 32.4 26.6 15.2 14.0 22.7 18.8 10.0 DPP7 "DPP2, DPPII" ENSG00000176978 "Dipeptidyl peptidase 7" Q9UHL4 9 137110542-137115177 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Aminopeptidase, Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell line enhanced" "Detected in many" "RPMI-8226: 56.7;THP-1: 54.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA021282, CAB025541, HPA059381" Supported Supported "Golgi apparatus,Vesicles" "Intracellular and membrane" 1300000 "Golgi apparatus, Vesicles" "CAB025541: , HPA021282: AB_1847673, HPA059381: " "unprognostic (1.15e-1)" "unprognostic (5.54e-2)" "prognostic unfavourable (6.07e-6)" "unprognostic (6.78e-3)" "unprognostic (1.25e-1)" "unprognostic (8.33e-2)" "unprognostic (7.49e-2)" "unprognostic (6.10e-2)" "unprognostic (2.28e-2)" "unprognostic (5.71e-3)" "prognostic favourable (8.31e-5)" "unprognostic (7.99e-2)" "unprognostic (1.46e-2)" "unprognostic (2.56e-2)" "unprognostic (1.72e-1)" "unprognostic (2.15e-1)" "unprognostic (1.02e-1)" 28.1 45.2 23.7 23.4 35.3 31.8 20.8 23.5 27.5 21.5 22.0 24.9 40.7 23.2 17.5 35.8 19.1 27.0 30.2 44.7 24.6 29.2 21.0 29.9 25.6 34.8 29.7 25.9 14.3 55.4 23.3 42.5 21.9 24.2 28.8 6.9 32.8 73.1 41.6 25.3 26.9 17.8 22.8 21.7 29.1 24.4 30.9 26.8 18.9 41.2 17.5 24.7 21.3 16.6 20.0 60.8 12.2 43.1 19.2 36.8 38.2 6.8 10.9 0.9 0.9 13.5 10.8 1.4 10.4 17.0 6.9 4.5 10.3 5.7 13.6 11.4 6.8 14.9 8.0 2.0 0.3 13.3 0.5 6.2 15.0 0.3 30.2 16.8 34.9 13.3 8.3 3.0 6.2 9.0 13.6 10.6 4.6 19.0 8.4 16.0 3.7 10.7 12.4 0.1 56.7 11.0 7.7 17.4 12.1 12.0 31.6 29.4 11.3 54.5 10.9 17.7 6.0 11.2 7.2 13.0 7.4 3.6 21.2 10.2 7.9 6.8 43.1 12.2 34.4 37.6 35.5 19.7 31.1 29.6 41.7 20.0 28.1 25.1 2.6 19.2 22.6 60.8 36.8 38.2 23.7 35.3 23.5 27.5 24.6 29.2 29.7 25.9 24.2 26.8 DPP8 "DP8, DPRP1, FLJ14920, FLJ20283, MGC26191, MSTP141" ENSG00000074603 "Dipeptidyl peptidase 8" Q6V1X1 15 65442463-65517704 "Enzymes, Plasma proteins, Predicted intracellular proteins" Apoptosis "Aminopeptidase, Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA008706 Approved Supported Cytosol Cytosol "HPA008706: AB_1078665" "unprognostic (3.65e-1)" "unprognostic (2.38e-2)" "unprognostic (2.15e-1)" "unprognostic (1.13e-1)" "unprognostic (1.24e-1)" "unprognostic (8.60e-2)" "unprognostic (2.98e-1)" "unprognostic (2.46e-1)" "unprognostic (2.52e-2)" "unprognostic (1.81e-1)" "unprognostic (4.09e-2)" "unprognostic (3.60e-2)" "unprognostic (1.99e-2)" "unprognostic (1.01e-1)" "unprognostic (7.58e-2)" "unprognostic (8.56e-2)" "unprognostic (2.59e-1)" 15.6 16.1 16.4 14.9 18.8 16.2 13.9 22.9 24.9 15.5 14.5 15.0 12.7 18.0 15.9 13.9 13.1 11.1 12.4 18.8 15.1 14.6 16.0 9.9 13.3 16.0 15.4 11.8 16.2 11.7 22.2 14.5 15.9 21.7 13.5 15.8 13.9 15.6 20.8 30.5 14.2 16.5 16.2 17.5 17.2 13.2 29.9 15.8 22.5 17.4 12.5 16.0 16.2 13.2 10.7 8.1 20.0 10.8 6.1 10.3 5.3 9.4 15.3 10.1 10.1 11.4 16.4 8.6 15.3 18.1 13.7 13.2 6.6 8.2 16.7 12.1 19.1 17.7 19.5 11.0 16.8 14.1 12.1 16.1 11.8 6.3 11.9 20.7 15.9 12.2 10.5 11.1 10.5 15.0 10.9 15.6 16.8 7.6 11.0 7.6 6.9 7.9 14.7 18.7 16.2 11.3 20.6 7.2 12.7 9.9 10.1 15.4 9.3 12.4 18.9 18.4 12.9 8.7 16.3 20.2 26.4 17.0 13.9 20.9 13.2 20.0 9.1 11.1 9.9 9.2 10.3 9.2 8.6 9.5 8.1 10.7 8.6 9.2 18.3 6.1 10.8 7.5 8.9 5.3 16.4 18.8 22.9 24.4 15.1 14.6 15.4 11.8 21.7 15.8 DPP9 ENSG00000142002 "Dipeptidyl peptidase 9" Q86TI2 19 4675224-4724673 "Enzymes, Predicted intracellular proteins" "Aminopeptidase, Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA036059 Approved Supported Cytosol Cytosol "HPA036059: AB_10671240" "prognostic favourable (4.96e-4)" "unprognostic (4.16e-2)" "unprognostic (2.03e-1)" "prognostic favourable (6.21e-5)" "unprognostic (5.67e-2)" "unprognostic (8.30e-2)" "unprognostic (1.66e-1)" "unprognostic (1.23e-1)" "unprognostic (8.85e-2)" "unprognostic (6.38e-2)" "unprognostic (1.93e-1)" "unprognostic (3.39e-2)" "prognostic unfavourable (3.38e-8)" "prognostic favourable (7.72e-5)" "unprognostic (1.55e-1)" "unprognostic (4.22e-1)" "unprognostic (1.80e-1)" 18.1 11.9 11.7 24.3 14.0 25.8 13.7 13.0 12.5 12.6 16.3 14.2 15.8 18.3 15.3 10.5 17.4 11.6 13.5 19.7 11.0 7.2 13.5 38.6 19.3 20.7 14.7 7.1 13.5 15.5 9.5 9.8 15.2 11.7 14.0 13.1 14.2 13.1 12.9 46.4 21.5 18.9 14.2 9.3 21.0 14.7 7.1 13.9 24.3 14.6 16.3 17.0 16.0 21.7 10.3 9.0 10.0 10.5 13.4 13.8 8.0 23.5 18.8 5.5 8.7 8.5 11.9 10.1 13.8 18.4 23.3 15.2 16.9 18.3 11.2 10.5 17.8 16.1 11.3 63.6 14.3 14.3 10.9 8.1 10.3 14.4 13.0 14.2 17.8 9.1 14.8 36.4 21.6 21.0 11.2 24.9 20.1 6.4 16.5 9.2 11.4 28.0 10.3 11.9 13.0 12.1 16.2 7.9 7.1 11.9 21.6 9.1 5.9 11.9 16.9 20.9 9.1 32.3 27.5 17.4 18.1 11.2 20.4 16.5 17.5 10.0 8.8 9.4 13.8 10.5 10.5 10.3 6.4 11.2 9.0 6.8 6.3 9.9 4.7 13.4 7.8 4.3 11.3 8.0 11.7 14.0 13.0 12.5 11.0 7.2 14.7 7.1 11.7 13.9 ECE1 ECE ENSG00000117298 "Endothelin converting enzyme 1" P42892 1 21217247-21345504 "Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Metalloprotease, Protease" "Disease mutation, Hirschsprung disease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "parathyroid gland: 114.4" "Cell line enhanced" "Detected in all" "HUVEC TERT2: 101.6;TIME: 90.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Cell type enhanced" "Detected in many" "neutrophil: 21.5" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA001490, HPA013616" Enhanced 2100000 "HPA001490: AB_1078718, HPA013616: AB_1847963" "unprognostic (7.90e-2)" "unprognostic (1.01e-1)" "unprognostic (1.48e-1)" "unprognostic (1.99e-2)" "unprognostic (1.49e-2)" "unprognostic (1.46e-1)" "unprognostic (5.24e-2)" "unprognostic (1.23e-1)" "unprognostic (6.20e-2)" "unprognostic (1.92e-3)" "unprognostic (1.04e-1)" "unprognostic (2.56e-1)" "unprognostic (7.70e-2)" "unprognostic (3.55e-2)" "unprognostic (9.10e-2)" "unprognostic (1.97e-2)" "unprognostic (1.97e-2)" 44.0 49.9 10.3 18.7 14.5 17.3 33.7 3.6 15.6 29.5 27.5 19.2 11.2 12.4 24.0 10.5 15.6 19.1 23.0 30.9 12.4 8.0 14.9 41.8 30.1 14.4 13.9 13.4 34.2 42.1 114.4 21.6 27.0 14.6 27.9 14.6 26.5 14.7 11.4 15.2 14.8 23.2 24.1 13.2 23.5 18.9 19.1 14.7 9.5 23.2 10.7 19.1 34.2 37.0 4.6 2.0 21.5 7.5 1.0 6.1 4.2 13.6 9.2 11.8 5.9 17.1 18.2 6.8 20.3 35.5 11.1 10.2 6.6 42.0 4.9 51.2 20.5 5.8 4.8 9.7 9.7 12.4 4.0 7.1 14.2 5.3 22.8 1.0 1.8 9.5 11.4 17.1 8.5 101.6 1.4 2.6 9.4 2.8 2.0 1.6 3.6 7.2 2.5 6.8 7.1 17.3 2.5 4.0 9.8 20.2 11.9 8.8 8.5 2.9 90.1 25.0 12.2 11.0 11.7 4.1 6.9 5.7 52.0 2.4 30.2 0.1 5.8 2.2 2.2 7.5 3.3 4.6 4.6 3.5 0.5 3.1 3.1 1.9 21.5 1.0 5.2 2.0 6.1 4.2 10.3 14.5 3.6 15.6 12.4 8.0 13.9 13.4 14.6 14.7 ECEL1 "DINE, XCE" ENSG00000171551 "Endothelin converting enzyme like 1" O95672 2 232479827-232487828 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Metalloprotease, Protease" "Disease mutation" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 28.6;ovary: 57.1" "Group enriched" "Detected in some" 6 "AN3-CA: 29.4;HeLa: 15.0" "Cancer enhanced" "Detected in many" "endometrial cancer: 12.9" "Region enriched" "Detected in many" 5 "hypothalamus: 28.6" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" "HPA067560, HPA069756, HPA077424" Approved Supported Approved "Nucleoplasm,Nuclear membrane,Nucleoli" Nucleoplasm "Nuclear membrane, Nucleoli" "HPA067560: , HPA069756: , HPA077424: " "unprognostic (1.21e-2)" "unprognostic (1.06e-2)" "unprognostic (4.39e-1)" "unprognostic (4.62e-3)" "unprognostic (2.80e-1)" "unprognostic (9.96e-4)" "unprognostic (7.56e-3)" "unprognostic (1.22e-1)" "unprognostic (9.89e-3)" "unprognostic (8.49e-2)" "unprognostic (1.54e-1)" "unprognostic (2.89e-1)" "unprognostic (1.24e-5)" "unprognostic (3.09e-2)" "unprognostic (3.68e-1)" "unprognostic (7.84e-2)" "unprognostic (5.45e-2)" 0.9 2.6 0.5 0.9 4.0 0.2 0.4 0.7 1.2 0.3 0.4 0.5 0.1 0.3 0.6 4.9 0.3 1.7 1.0 1.1 0.1 28.6 1.0 0.7 0.2 1.2 0.3 0.1 57.1 0.6 0.3 8.9 0.4 5.5 0.3 0.2 11.5 0.3 1.2 1.8 0.3 0.3 1.1 4.5 2.0 0.3 0.8 1.6 0.1 0.5 0.3 0.5 0.3 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.1 29.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.7 0.0 0.4 0.3 0.0 0.0 0.4 0.0 0.0 0.0 2.6 0.0 15.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 2.1 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.0 0.0 0.0 0.0 3.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 4.0 0.7 1.2 0.1 28.6 0.3 0.1 5.5 1.6 ELANE "ELA2, HLE, HNE, NE" ENSG00000197561 "Elastase, neutrophil expressed" P08246 19 851014-856247 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Cancer-related genes, Disease mutation, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 8 "bone marrow: 244.3" "Cell line enriched" "Detected in some" 65 "THP-1: 193.2" "Group enriched" "Detected in some" 7 "pancreatic cancer: 3.5;stomach cancer: 3.7" "Not detected" "Not detected" "Group enriched" "Detected in some" 9 "classical monocyte: 3.2;neutrophil: 6.9" "Group enriched" "Detected in many" 9 "granulocytes: 6.9;monocytes: 3.2" "Not detected" "Not detected" "Low region specificity" "Detected in single" "CAB015409, HPA066836" Enhanced "Secreted to blood" 59000 "CAB015409: AB_831596, HPA066836: " "unprognostic (3.46e-2)" "unprognostic (1.10e-1)" "unprognostic (1.42e-3)" "unprognostic (2.09e-2)" "unprognostic (1.80e-3)" "unprognostic (3.43e-2)" "unprognostic (3.92e-1)" "unprognostic (6.38e-3)" "unprognostic (5.80e-1)" "unprognostic (2.54e-2)" "unprognostic (4.06e-2)" "unprognostic (3.48e-2)" "unprognostic (1.19e-10)" "unprognostic (6.27e-3)" "unprognostic (4.00e-2)" "unprognostic (2.76e-2)" "unprognostic (4.75e-3)" 1.5 0.3 0.1 0.3 0.1 244.3 1.6 0.2 0.6 0.3 0.6 0.7 0.0 0.3 0.3 0.7 0.5 0.6 0.8 31.2 0.0 0.0 0.3 1.5 17.8 1.6 0.0 0.0 0.3 1.8 0.3 0.4 4.7 0.5 1.4 0.3 1.0 0.7 0.3 1.1 2.1 0.5 0.5 0.0 22.5 0.5 0.3 0.0 23.0 2.3 0.9 0.3 1.0 0.2 0.0 0.0 6.9 3.2 0.0 0.5 11.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 193.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.9 0.0 0.0 3.2 0.0 0.5 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.9 0.0 0.0 0.0 0.0 11.2 0.1 0.1 0.2 0.6 0.0 0.0 0.0 0.0 0.5 0.0 ENPEP "CD249, gp160" ENSG00000138792 "Glutamyl aminopeptidase" Q07075 4 110365733-110565285 "CD markers, Enzymes, Plasma proteins, Predicted membrane proteins" "Aminopeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 165.1;kidney: 63.8" "Cell line enhanced" "Detected in some" "BEWO: 4.5;HEK 293: 12.1;MOLT-4: 2.9" "Cancer enriched" "Detected in many" 8 "renal cancer: 41.0" "Low region specificity" "Detected in single" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" HPA005128 Enhanced 37000000 "HPA005128: AB_1844795" "unprognostic (2.73e-3)" "unprognostic (2.84e-3)" "unprognostic (5.16e-3)" "unprognostic (3.48e-1)" "unprognostic (2.90e-1)" "unprognostic (8.74e-2)" "unprognostic (3.34e-2)" "unprognostic (1.03e-1)" "unprognostic (1.35e-2)" "unprognostic (1.22e-1)" "unprognostic (1.93e-1)" "unprognostic (9.47e-2)" "unprognostic (4.49e-3)" "unprognostic (3.43e-3)" "unprognostic (1.52e-2)" "unprognostic (8.46e-2)" "unprognostic (2.49e-3)" 5.8 1.0 0.4 0.4 0.6 0.0 2.8 0.3 1.0 1.1 54.4 0.4 0.7 11.1 5.3 2.4 0.8 1.4 1.1 2.3 0.5 0.3 63.8 14.5 2.7 0.5 0.4 0.3 1.0 1.0 33.3 0.8 4.4 0.5 1.4 0.0 0.8 0.6 0.5 2.3 0.4 165.1 3.1 0.5 4.7 0.7 0.4 0.4 1.4 2.4 2.0 0.4 1.0 1.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.4 0.1 0.0 0.1 0.3 4.5 0.6 0.0 0.2 0.4 0.1 0.0 0.0 0.2 0.1 0.0 0.2 0.0 0.1 0.0 12.1 0.0 0.0 0.0 0.0 0.0 0.0 1.6 0.0 0.0 0.0 0.0 0.0 0.0 0.2 1.6 2.9 0.5 0.5 0.0 0.2 0.0 0.5 0.0 0.5 0.1 0.3 0.0 2.1 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 1.2 2.2 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.6 0.3 1.0 0.5 0.3 0.4 0.3 0.5 0.4 EPHX1 EPHX ENSG00000143819 "Epoxide hydrolase 1" P07099 1 225810092-225845563 "Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" "Aromatic hydrocarbons catabolism, Detoxification" Hydrolase "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "adrenal gland: 156.4;liver: 265.0" "Cell line enhanced" "Detected in many" "ASC diff: 153.8;SiHa: 73.1" "Cancer enriched" "Detected in all" 6 "liver cancer: 1047.0" "Low region specificity" "Detected in all" "Cell type enhanced" "Detected in many" "classical monocyte: 6.6" "Low lineage specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA020593, HPA048847" Enhanced 83000 "HPA020593: AB_10601373, HPA048847: AB_2680538" "unprognostic (2.85e-2)" "unprognostic (2.52e-2)" "unprognostic (2.00e-2)" "unprognostic (2.53e-3)" "unprognostic (2.50e-1)" "unprognostic (6.60e-2)" "unprognostic (3.92e-2)" "prognostic favourable (7.02e-5)" "unprognostic (1.02e-1)" "unprognostic (2.53e-2)" "unprognostic (1.01e-1)" "prognostic favourable (1.32e-4)" "unprognostic (8.10e-2)" "unprognostic (1.80e-1)" "unprognostic (1.65e-1)" "unprognostic (5.15e-2)" "unprognostic (1.88e-2)" 39.5 156.4 16.8 5.7 20.1 3.4 31.3 8.3 25.1 31.3 12.6 28.7 15.3 16.6 21.8 15.7 24.9 26.2 17.8 11.5 16.3 11.2 36.8 265.0 24.1 6.9 17.1 14.5 45.6 85.0 39.5 14.0 5.4 23.6 25.9 8.4 27.3 26.3 21.3 16.4 8.8 9.6 18.6 10.7 8.3 12.1 22.7 12.6 3.6 24.9 15.6 14.9 20.9 32.3 0.5 2.2 0.5 6.6 1.4 1.3 2.3 4.4 42.3 1.6 15.6 153.8 16.0 3.4 5.1 6.4 3.7 5.2 8.7 45.0 0.1 19.3 19.2 4.9 4.6 2.4 1.5 0.9 8.0 3.1 17.9 48.8 16.7 1.9 1.8 15.0 5.6 10.5 1.0 2.7 2.2 3.9 6.6 5.1 1.9 3.6 9.1 11.9 4.1 2.0 12.8 11.1 27.9 14.6 1.9 73.1 26.2 6.7 19.4 5.7 8.1 6.3 5.1 8.5 8.1 1.3 6.7 0.5 9.5 2.1 8.3 0.0 6.6 0.2 0.5 1.9 0.9 0.3 0.9 0.5 1.5 0.5 1.3 1.0 0.5 1.4 0.8 2.2 0.7 2.3 16.8 20.1 8.3 25.1 16.3 11.2 17.1 14.5 23.6 12.6 ERAP1 "A-LAP, ARTS-1, ERAAP1, KIAA0525, PILS-AP" ENSG00000164307 "Endoplasmic reticulum aminopeptidase 1" Q9NZ08 5 96760810-96808100 "Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Adaptive immunity, Immunity" "Aminopeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB025095, HPA042317" Approved Approved "Nucleoplasm,Plasma membrane,Cytosol" "Secreted to blood" 27000000 "Nucleoplasm, Cytosol" "Plasma membrane" "CAB025095: , HPA042317: " "unprognostic (2.33e-3)" "unprognostic (3.45e-1)" "unprognostic (1.84e-3)" "unprognostic (1.34e-1)" "unprognostic (1.86e-1)" "unprognostic (4.38e-1)" "unprognostic (1.88e-3)" "unprognostic (5.37e-2)" "unprognostic (1.45e-1)" "unprognostic (7.94e-2)" "unprognostic (4.52e-2)" "unprognostic (3.23e-1)" "unprognostic (7.09e-2)" "unprognostic (1.36e-1)" "unprognostic (3.93e-2)" "unprognostic (1.19e-1)" "unprognostic (5.14e-2)" 23.8 13.6 9.3 22.7 11.9 11.6 23.3 14.2 14.6 14.5 23.8 10.1 11.2 30.8 14.7 13.4 12.3 14.3 19.9 16.1 9.7 6.8 13.3 23.7 17.8 16.4 13.5 7.6 15.5 16.5 11.1 39.4 28.2 11.4 13.4 21.9 8.5 13.9 15.2 23.1 17.7 39.7 10.6 17.1 19.5 16.5 5.4 13.8 55.5 13.5 9.8 17.8 15.9 14.1 14.9 15.2 19.8 17.5 19.8 21.8 10.7 7.3 4.7 6.3 5.9 35.0 34.3 18.4 5.4 17.5 13.1 23.0 5.9 26.7 22.0 11.3 10.4 7.6 5.2 11.1 8.2 39.8 2.2 7.1 3.1 4.0 40.1 3.4 13.2 14.2 4.8 15.0 4.6 18.0 3.7 21.4 7.8 3.4 31.6 3.5 3.1 3.0 23.5 8.6 10.9 9.8 11.4 2.3 1.6 8.6 5.8 8.4 5.1 16.4 14.3 11.3 3.8 1.9 8.9 8.0 15.0 17.1 12.1 11.6 6.6 19.8 13.2 15.6 21.2 11.4 19.7 13.0 18.5 18.2 9.5 14.9 21.8 17.4 14.4 19.8 17.5 15.2 12.3 10.7 9.3 11.9 14.2 14.6 9.7 6.8 13.5 7.6 11.4 13.8 ERAP2 "L-RAP, LRAP" ENSG00000164308 "Endoplasmic reticulum aminopeptidase 2" Q6P179 5 96875939-96919716 "Enzymes, Predicted intracellular proteins, Predicted secreted proteins" "Adaptive immunity, Immunity" "Aminopeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell line enhanced" "Detected in many" "CAPAN-2: 49.3;hTEC/SVTERT24-B: 23.7;MOLT-4: 26.3;TIME: 51.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB025618, HPA034498, HPA064360" Enhanced Approved "Golgi apparatus" "Secreted to blood" 7400000 "Golgi apparatus" "CAB025618: , HPA034498: , HPA064360: " "unprognostic (4.62e-2)" "unprognostic (1.60e-1)" "unprognostic (4.98e-2)" "unprognostic (1.56e-1)" "unprognostic (3.14e-1)" "unprognostic (8.71e-2)" "unprognostic (2.60e-2)" "unprognostic (1.17e-2)" "unprognostic (5.03e-2)" "unprognostic (1.40e-1)" "prognostic unfavourable (1.20e-4)" "unprognostic (1.01e-1)" "unprognostic (9.54e-3)" "unprognostic (6.59e-2)" "unprognostic (8.48e-2)" "unprognostic (4.65e-2)" "unprognostic (3.05e-1)" 9.0 6.0 3.1 21.6 3.8 3.5 7.4 2.2 3.5 9.6 37.0 3.1 6.2 17.0 8.3 10.3 12.4 5.7 5.6 5.8 3.3 2.6 8.6 10.8 16.8 30.8 4.2 0.5 18.2 5.9 1.4 11.1 13.6 3.6 9.4 3.1 7.0 9.3 3.5 4.1 4.9 22.4 5.1 8.7 37.6 9.2 2.6 3.1 32.5 11.3 9.6 24.4 11.8 8.7 16.4 10.7 10.9 15.3 24.0 22.4 14.1 0.5 0.6 0.4 0.2 0.5 1.0 0.1 2.1 3.7 2.0 3.3 2.1 49.3 2.9 9.7 3.1 0.7 0.2 17.9 1.6 1.0 2.1 0.1 0.7 2.0 0.7 10.9 5.2 7.3 3.3 23.7 0.1 1.3 0.0 7.3 5.6 0.3 26.3 5.4 0.0 1.0 11.8 4.2 7.7 14.3 4.2 0.9 0.0 0.3 0.2 4.1 1.7 0.4 51.6 1.0 0.3 2.8 6.4 7.2 6.1 1.0 14.4 1.4 0.2 10.9 6.5 7.8 14.2 15.3 18.1 16.4 20.2 17.6 10.7 9.6 22.4 17.0 2.2 24.0 14.4 3.5 18.2 14.1 3.1 3.8 2.2 3.5 3.3 2.6 4.2 0.5 3.6 3.1 ERMP1 "FLJ23309, FXNA, KIAA1815" ENSG00000099219 "Endoplasmic reticulum metallopeptidase 1" Q7Z2K6 9 5765076-5833117 "Enzymes, Predicted membrane proteins" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "parathyroid gland: 57.6" "Cell line enhanced" "Detected in many" "RPTEC TERT1: 26.9;RT4: 52.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Cell type enhanced" "Detected in some" "NK-cell: 4.7" "Low lineage specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA055582 Approved "HPA055582: " "unprognostic (1.93e-2)" "unprognostic (3.40e-1)" "unprognostic (2.76e-2)" "unprognostic (5.93e-2)" "unprognostic (2.97e-1)" "unprognostic (8.59e-2)" "unprognostic (4.30e-3)" "unprognostic (2.81e-1)" "unprognostic (5.46e-2)" "unprognostic (4.83e-3)" "unprognostic (3.14e-2)" "unprognostic (2.88e-2)" "prognostic favourable (5.83e-10)" "unprognostic (1.41e-1)" "unprognostic (4.00e-1)" "unprognostic (5.77e-2)" "unprognostic (1.36e-1)" 4.0 12.0 5.3 3.6 13.8 1.6 4.8 7.3 12.3 8.5 8.2 20.5 1.5 3.4 4.9 2.9 12.7 4.9 8.8 7.1 6.8 5.8 18.8 3.5 4.7 2.7 18.3 7.0 5.6 4.4 57.6 3.3 5.7 17.0 4.8 8.4 6.9 12.8 3.4 5.2 6.8 4.8 3.2 15.9 2.5 9.1 5.9 11.5 4.6 19.1 4.6 7.2 18.7 8.1 0.2 0.3 0.9 0.5 4.7 2.0 0.3 15.0 14.7 0.6 1.7 7.7 7.4 7.8 1.7 3.8 0.8 0.7 3.5 9.2 3.5 6.7 2.8 10.8 3.2 10.0 1.2 18.5 2.6 18.7 7.7 6.9 1.6 5.3 7.4 3.7 4.4 0.7 4.4 10.4 2.3 3.3 0.9 6.9 0.2 2.0 2.3 2.9 0.5 1.8 4.7 26.9 52.6 3.4 1.0 2.4 17.8 2.8 11.7 6.7 6.1 0.5 1.8 1.1 5.4 3.1 4.4 1.8 2.2 4.4 1.4 0.6 0.3 0.9 1.3 0.5 2.0 0.2 0.6 0.3 0.0 0.0 0.5 0.5 0.0 4.7 0.2 0.3 0.5 0.3 5.3 13.8 7.3 12.3 6.8 5.8 18.3 7.0 17.0 11.5 F10 ENSG00000126218 "Coagulation factor X" P00742 13 113122814-113149529 "Candidate cardiovascular disease genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins" "Blood coagulation, Hemostasis" "Hydrolase, Protease, Serine protease" "Disease mutation, FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 5 "liver: 116.7" "Cell line enhanced" "Detected in some" "BJ: 8.3;CACO-2: 7.1;fHDF/TERT166: 7.4;Hep G2: 32.8;HHSteC: 6.8;SH-SY5Y: 16.2" "Cancer enriched" "Detected in many" 11 "liver cancer: 95.4" "Low region specificity" "Detected in single" "Cell type enhanced" "Detected in single" "MAIT T-cell: 1.0" "Low lineage specificity" "Detected in single" "Not detected" "Not detected" "Low region specificity" "Detected in all" "Secreted to blood" 16000000000 "unprognostic (4.18e-2)" "unprognostic (1.07e-1)" "unprognostic (7.62e-2)" "unprognostic (9.88e-2)" "unprognostic (9.44e-2)" "unprognostic (1.15e-2)" "unprognostic (4.90e-2)" "unprognostic (1.02e-2)" "unprognostic (2.54e-1)" "unprognostic (1.24e-1)" "prognostic favourable (1.82e-5)" "unprognostic (6.39e-2)" "prognostic unfavourable (5.14e-5)" "unprognostic (6.60e-2)" "unprognostic (1.21e-1)" "unprognostic (3.87e-2)" "unprognostic (2.23e-3)" 8.1 3.7 0.3 2.9 0.7 0.0 5.4 0.4 0.8 20.3 5.9 0.6 7.6 4.5 12.6 21.4 4.5 9.9 10.0 18.4 0.5 0.5 2.3 116.7 4.9 1.6 0.5 0.7 18.2 3.0 0.0 1.7 3.6 1.0 18.1 0.7 6.9 2.0 6.1 2.6 7.8 7.6 11.7 0.6 1.3 3.2 9.5 0.6 0.6 3.1 5.6 1.8 7.8 10.3 0.0 0.0 0.0 0.0 0.9 1.0 0.3 0.0 0.0 1.4 0.2 4.8 4.9 0.0 8.3 6.6 0.5 0.2 7.1 0.0 0.0 0.3 7.4 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.1 32.8 6.8 0.0 0.2 4.8 0.0 0.0 0.0 0.0 0.0 0.1 0.8 0.0 0.0 0.1 0.0 0.1 0.1 0.0 0.0 0.0 0.1 0.6 16.2 0.0 0.3 0.0 0.3 0.1 0.0 0.0 0.4 0.1 0.0 0.1 0.0 0.0 0.1 0.1 0.2 0.0 0.0 0.0 0.2 0.0 1.0 0.0 0.1 0.0 0.0 0.0 0.1 0.3 0.0 0.9 0.0 0.0 0.0 0.3 0.3 0.7 0.4 0.8 0.5 0.5 0.5 0.7 1.0 0.6 F11 FXI ENSG00000088926 "Coagulation factor XI" P03951 4 186265945-186288806 "Candidate cardiovascular disease genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Blood coagulation, Hemostasis" "Heparin-binding, Hydrolase, Protease, Serine protease" "Disease mutation, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 5 "liver: 88.9" "Cell line enriched" "Detected in some" 11 "Hep G2: 13.7" "Cancer enriched" "Detected in some" 13 "liver cancer: 16.8" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA039808 Approved Vesicles "Secreted to blood" 4400000000 Vesicles "HPA039808: " "unprognostic (1.28e-1)" "unprognostic (3.15e-1)" "prognostic favourable (3.29e-5)" "unprognostic (1.88e-1)" "unprognostic (2.08e-1)" "unprognostic (2.11e-1)" "unprognostic (1.85e-3)" "unprognostic (2.91e-2)" "unprognostic (7.65e-2)" 0.1 0.1 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.3 2.7 0.1 0.1 5.5 0.2 0.3 0.1 0.1 4.8 0.1 0.1 0.1 10.2 88.9 2.8 0.1 0.1 0.1 0.1 19.0 0.0 0.2 0.1 0.3 0.1 0.0 0.4 0.1 0.1 0.1 0.1 6.1 0.1 0.1 0.1 0.1 0.1 0.2 0.1 0.1 0.1 0.1 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 13.7 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.1 0.4 0.2 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.3 0.2 F12 ENSG00000131187 "Coagulation factor XII" P00748 5 177402140-177409576 "Candidate cardiovascular disease genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins" "Blood coagulation, Fibrinolysis, Hemostasis" "Hydrolase, Protease, Serine protease" "Disease mutation, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 26 "liver: 180.1" "Cell line enhanced" "Detected in some" "HDLM-2: 8.6;MCF7: 10.9;PC-3: 8.1;SH-SY5Y: 5.5;U-937: 5.6" "Cancer enriched" "Detected in many" 21 "liver cancer: 171.0" "Not detected" "Not detected" "Group enriched" "Detected in some" 5 "classical monocyte: 2.5;eosinophil: 6.9" "Group enriched" "Detected in many" 5 "granulocytes: 6.9;monocytes: 2.5" "Low region specificity" "Detected in some" "Low region specificity" "Detected in all" HPA003825 Approved "Secreted to blood" 1040000 6600000000 "HPA003825: AB_1078790" "unprognostic (9.75e-2)" "unprognostic (1.71e-1)" "unprognostic (2.93e-1)" "unprognostic (4.47e-2)" "unprognostic (1.01e-1)" "unprognostic (2.32e-1)" "prognostic favourable (4.63e-5)" "unprognostic (6.97e-2)" "unprognostic (1.26e-2)" "unprognostic (3.96e-2)" "unprognostic (4.41e-1)" "unprognostic (6.54e-2)" "prognostic unfavourable (7.09e-4)" "unprognostic (4.11e-2)" "unprognostic (3.69e-1)" "unprognostic (3.40e-6)" "unprognostic (6.48e-2)" 0.1 0.0 0.1 0.1 0.1 0.7 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.2 0.0 0.1 0.1 0.1 0.1 0.2 180.1 0.1 0.1 0.1 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.5 1.0 6.9 2.5 0.7 0.3 1.0 0.8 2.0 0.0 0.5 0.0 0.0 0.2 0.0 0.1 0.0 0.0 2.3 1.3 0.0 0.4 0.0 1.4 0.7 0.4 0.0 8.6 1.8 1.3 0.3 0.9 0.2 0.7 3.0 0.2 1.3 0.1 0.4 0.2 0.4 3.2 0.0 10.9 0.1 2.6 0.0 8.1 0.6 0.2 1.8 1.1 0.0 2.5 5.5 0.3 1.0 0.7 0.4 0.0 0.0 0.2 1.1 0.0 0.3 0.5 0.0 0.1 0.1 5.6 0.6 0.0 2.5 6.9 0.3 0.1 0.2 0.5 0.3 0.2 0.1 0.2 0.0 0.1 0.9 0.7 0.9 1.0 0.0 1.0 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 F2 ENSG00000180210 "Coagulation factor II, thrombin" P00734 11 46719180-46739506 "Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Acute phase, Blood coagulation, Hemostasis" "Hydrolase, Protease, Serine protease" "Cancer-related genes, Disease mutation, FDA approved drug targets, Thrombophilia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 593 "liver: 324.8" "Cell line enriched" "Detected in some" 21 "Hep G2: 76.5" "Cancer enriched" "Detected in some" 110 "liver cancer: 508.2" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in many" "CAB016780, CAB018650, HPA051476, HPA054698" Enhanced "Secreted to blood" 107500000000 43000000000 "CAB016780: , CAB018650: AB_2246689, HPA051476: , HPA054698: " "unprognostic (1.98e-1)" "unprognostic (2.52e-1)" "unprognostic (2.64e-2)" "unprognostic (1.85e-1)" "unprognostic (2.29e-1)" "unprognostic (2.81e-1)" "unprognostic (2.23e-2)" "unprognostic (3.94e-2)" "unprognostic (5.79e-2)" "unprognostic (8.29e-2)" "unprognostic (4.46e-2)" "prognostic unfavourable (6.75e-12)" "unprognostic (5.65e-3)" "unprognostic (5.80e-2)" "unprognostic (1.54e-3)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.0 0.0 0.0 0.0 324.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.1 0.5 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.6 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 76.5 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.1 0.0 0.5 0.0 0.5 0.0 0.1 0.4 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 F7 ENSG00000057593 "Coagulation factor VII" P08709 13 113105788-113120681 "Candidate cardiovascular disease genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins" "Blood coagulation, Hemostasis" "Hydrolase, Protease, Serine protease" "Disease mutation, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 39 "liver: 68.0" "Group enriched" "Detected in some" 9 "CACO-2: 16.2;Hep G2: 10.1" "Cancer enriched" "Detected in some" 17 "liver cancer: 41.4" "Not detected" "Not detected" "Group enriched" "Detected in some" 15 "gdT-cell: 1.7;MAIT T-cell: 1.2;memory CD8 T-cell: 1.6" "Lineage enriched" "Detected in single" 17 "T-cells: 1.7" "Not detected" "Not detected" "Not detected" "Not detected" HPA004826 Approved Mitochondria "Secreted to blood" 3600000 1500000000 Mitochondria "HPA004826: AB_10602805" "unprognostic (2.06e-1)" "unprognostic (2.55e-1)" "unprognostic (1.03e-1)" "unprognostic (1.34e-1)" "unprognostic (3.27e-1)" "unprognostic (1.91e-1)" "unprognostic (1.50e-3)" "unprognostic (3.81e-1)" "unprognostic (4.36e-3)" "unprognostic (1.16e-1)" "unprognostic (4.19e-3)" "unprognostic (1.15e-1)" "unprognostic (1.35e-3)" "unprognostic (3.36e-3)" "unprognostic (1.09e-1)" "unprognostic (2.86e-1)" "unprognostic (1.47e-1)" 0.1 0.0 0.1 0.1 0.1 0.0 0.1 0.2 0.4 0.2 0.1 0.1 0.1 0.3 0.1 0.2 0.1 0.2 0.1 0.1 0.1 0.1 0.1 68.0 0.1 0.1 0.1 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.1 0.0 0.3 0.1 0.1 0.1 0.0 0.4 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.0 0.0 0.0 0.0 0.0 1.7 0.1 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 16.2 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 10.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.3 0.0 0.0 0.2 0.0 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 1.7 0.0 1.2 0.0 0.0 1.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.1 0.2 0.4 0.1 0.1 0.1 0.1 0.1 0.1 F9 FIX ENSG00000101981 "Coagulation factor IX" P00740 X 139530758-139563458 "Candidate cardiovascular disease genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins" "Blood coagulation, Hemostasis" "Hydrolase, Protease, Serine protease" "Disease mutation, FDA approved drug targets, Hemophilia, Thrombophilia" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 2334 "liver: 233.6" "Cell line enhanced" "Detected in some" "HL-60: 1.7;RH-30: 1.9;SiHa: 1.5;U-698: 1.1" "Cancer enriched" "Detected in single" 1354 "liver cancer: 67.6" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in single" "Not detected" "Not detected" "Secreted to blood" 11000000000 "prognostic favourable (6.69e-4)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 233.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 1.7 0.2 0.0 0.1 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 1.9 0.0 0.0 0.0 0.0 0.0 1.5 0.1 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.3 0.0 1.1 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 FAM105A "FLJ11127, NET20" ENSG00000145569 "Family with sequence similarity 105 member A" Q9NUU6 5 14581775-14615007 "Enzymes, Predicted membrane proteins" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 35.4" "Cell line enhanced" "Detected in many" "HeLa: 13.8;HMC-1: 43.3;THP-1: 12.0;U-937: 20.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA046638 Uncertain Approved Nucleoli,Cytosol "Nucleoli, Cytosol" "HPA046638: " "unprognostic (1.47e-1)" "unprognostic (6.64e-3)" "unprognostic (1.92e-2)" "unprognostic (1.15e-3)" "unprognostic (6.26e-2)" "unprognostic (1.13e-3)" "unprognostic (2.33e-2)" "unprognostic (2.27e-2)" "unprognostic (6.44e-2)" "unprognostic (2.42e-1)" "prognostic favourable (1.02e-4)" "unprognostic (2.13e-1)" "unprognostic (1.33e-2)" "unprognostic (2.38e-2)" "prognostic unfavourable (7.62e-4)" "unprognostic (3.14e-1)" "unprognostic (8.79e-3)" 5.1 3.5 4.0 7.9 4.9 35.4 5.2 3.1 5.1 6.3 15.4 9.0 4.5 8.3 3.0 5.6 2.9 3.1 4.1 3.0 3.9 4.3 5.2 1.9 28.8 16.7 6.1 3.8 4.0 13.3 1.9 8.7 6.7 7.9 12.6 17.3 10.3 3.1 13.5 1.3 2.6 13.7 3.3 10.8 13.2 5.4 4.4 4.1 3.5 27.2 3.0 6.2 7.1 5.8 0.1 26.7 6.9 26.2 14.1 9.6 16.2 0.0 0.6 1.2 0.0 0.2 0.0 5.2 1.5 1.4 0.4 0.7 1.9 1.3 0.0 0.8 0.7 0.1 2.6 1.2 0.6 0.8 3.6 3.4 13.8 0.3 1.3 0.0 43.3 0.1 0.3 0.2 0.0 0.0 0.0 5.4 0.1 1.0 0.0 1.2 1.9 9.2 0.3 0.5 1.5 0.0 10.4 4.5 5.0 0.7 0.4 0.0 0.4 12.0 0.0 0.6 3.4 0.2 1.1 0.0 0.0 0.0 0.7 20.5 0.2 0.0 26.2 0.1 4.5 12.4 6.0 0.1 5.7 6.1 26.7 0.1 7.8 7.5 6.9 14.1 9.4 19.7 9.6 16.2 4.0 4.9 3.1 5.1 3.9 4.3 6.1 3.8 7.9 4.1 FAP DPPIV ENSG00000078098 "Fibroblast activation protein alpha" Q12884 2 162170684-162245151 "Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Angiogenesis, Apoptosis, Cell adhesion" "Hydrolase, Protease, Serine protease" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "endometrium 1: 30.0" "Cell line enhanced" "Detected in some" "ASC diff: 47.0;ASC TERT1: 49.9;BJ hTERT+: 39.4;TIME: 19.7;U-138 MG: 40.1" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" HPA059739 Uncertain "Secreted to blood" 34000000 "HPA059739: " "unprognostic (7.48e-3)" "unprognostic (7.87e-3)" "unprognostic (4.10e-2)" "unprognostic (5.04e-2)" "unprognostic (1.49e-2)" "prognostic unfavourable (4.82e-4)" "unprognostic (2.01e-2)" "unprognostic (1.05e-2)" "unprognostic (3.30e-2)" "unprognostic (4.89e-2)" "unprognostic (4.59e-2)" "unprognostic (3.52e-1)" "unprognostic (7.32e-11)" "unprognostic (1.72e-3)" "unprognostic (9.84e-3)" "unprognostic (7.97e-2)" "unprognostic (4.49e-3)" 19.8 0.7 2.6 3.2 1.2 0.0 7.5 0.6 3.7 17.6 4.5 0.4 4.0 0.1 30.0 13.7 4.1 5.1 14.9 5.2 3.1 0.9 2.0 0.9 4.7 0.8 2.6 1.2 4.1 2.3 0.5 1.0 17.0 1.9 4.1 1.5 2.4 5.3 3.9 8.1 2.9 1.4 17.9 2.2 0.9 1.7 9.8 3.4 0.0 3.5 9.0 0.8 12.4 4.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 47.0 49.9 0.0 19.2 39.4 4.0 6.1 0.0 0.0 0.0 0.1 7.3 0.0 0.0 1.2 1.9 0.0 0.0 0.0 0.2 0.0 4.7 0.0 0.0 16.1 0.3 6.7 1.2 0.0 0.0 0.0 12.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 2.0 0.0 2.0 0.0 0.0 19.7 40.1 0.8 9.7 0.0 0.0 0.0 0.0 9.0 0.0 10.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.6 1.2 0.6 3.7 3.1 0.9 2.6 1.2 1.9 3.4 FOLH1 "FOLH, GCP2, GCPII, NAALAD1, NAALAdase, PSM, PSMA" ENSG00000086205 "Folate hydrolase 1" Q04609 11 49146635-49208670 "Cancer-related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Carboxypeptidase, Dipeptidase, Hydrolase, Metalloprotease, Multifunctional enzyme, Protease" "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 37.7;intestine: 111.2;prostate: 33.8" "Cell line enhanced" "Detected in some" "HAP1: 5.3;RPMI-8226: 3.7;SK-BR-3: 4.4;TIME: 2.8;WM-115: 5.3" "Cancer enriched" "Detected in many" 27 "prostate cancer: 142.7" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB001451, HPA010593" Enhanced "CAB001451: AB_563979, HPA010593: AB_1079685" "unprognostic (1.33e-1)" "unprognostic (1.19e-1)" "unprognostic (1.24e-1)" "prognostic favourable (5.24e-5)" "unprognostic (2.55e-1)" "unprognostic (8.31e-2)" "prognostic favourable (4.25e-4)" "unprognostic (1.32e-1)" "unprognostic (2.09e-2)" "unprognostic (2.67e-3)" "unprognostic (2.13e-2)" "unprognostic (2.72e-1)" "prognostic unfavourable (1.30e-6)" "unprognostic (4.81e-2)" "unprognostic (7.27e-2)" "unprognostic (4.74e-3)" "unprognostic (4.04e-1)" 1.2 1.0 10.4 0.9 16.4 0.8 2.5 1.4 12.7 1.4 67.6 37.7 0.0 111.2 1.3 0.8 1.2 2.1 5.0 0.7 16.9 8.7 6.1 15.7 1.1 0.9 19.0 9.1 1.0 0.7 0.7 0.4 0.7 17.7 33.8 0.8 0.6 20.7 0.8 0.6 1.2 61.1 1.0 33.0 1.5 1.0 0.9 16.2 0.0 1.0 0.0 0.8 1.2 0.5 0.9 0.1 0.3 0.8 1.4 1.2 0.0 0.3 0.0 0.1 0.0 0.0 0.0 2.6 0.3 0.0 0.0 0.0 0.0 0.9 0.2 0.6 0.0 0.2 5.3 0.5 0.0 1.2 0.9 0.0 0.5 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.0 0.0 1.1 1.0 0.0 0.3 0.3 3.7 0.0 0.0 0.4 1.6 0.0 4.4 1.0 1.0 0.0 2.8 0.2 2.7 0.4 0.3 0.1 0.5 0.1 0.0 0.9 5.3 0.1 0.8 0.3 0.9 0.6 0.2 0.6 1.2 0.5 0.0 0.9 0.7 0.3 0.2 1.4 0.5 0.1 0.4 0.0 10.4 16.4 1.4 12.7 16.9 8.7 19.0 9.1 17.7 16.2 FURIN "FUR, PACE, PCSK3, SPC1" ENSG00000140564 "Furin, paired basic amino acid cleaving enzyme" P09958 15 90868592-90883458 "Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Host-virus interaction" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in all" 9 "liver: 118.4;placenta: 158.9;salivary gland: 337.9" "Low cell line specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" CAB009499 Enhanced Supported "Nucleoplasm,Golgi apparatus" "Intracellular and membrane" 41000 "Golgi apparatus" Nucleoplasm "CAB009499: AB_2105095" "unprognostic (2.46e-1)" "unprognostic (2.73e-2)" "unprognostic (7.33e-2)" "unprognostic (2.30e-2)" "unprognostic (4.11e-3)" "unprognostic (4.37e-2)" "unprognostic (8.11e-2)" "prognostic unfavourable (1.58e-4)" "unprognostic (2.24e-1)" "unprognostic (9.92e-3)" "unprognostic (1.78e-1)" "unprognostic (1.96e-1)" "unprognostic (4.52e-3)" "unprognostic (4.57e-2)" "unprognostic (4.46e-2)" "unprognostic (4.27e-3)" "unprognostic (8.20e-2)" 8.3 3.3 3.0 7.5 3.6 16.6 5.9 5.0 4.4 4.1 6.6 2.8 3.5 5.7 4.9 10.8 4.7 4.4 3.9 6.9 3.1 1.8 6.4 118.4 9.5 3.1 2.8 2.7 4.2 22.5 3.8 7.2 158.9 3.5 9.3 2.2 3.0 337.9 4.7 8.7 9.0 5.9 3.1 3.0 8.2 6.0 5.3 2.9 4.8 8.9 5.5 4.1 4.4 4.3 1.5 3.3 10.3 3.3 3.1 1.9 2.0 14.1 8.6 1.9 8.7 14.3 9.2 22.2 17.8 13.6 7.4 5.2 12.6 15.5 0.5 45.9 12.9 25.5 3.9 9.2 1.6 40.7 10.1 24.8 15.5 16.5 7.6 3.4 40.9 10.4 10.4 8.4 3.8 23.6 18.9 2.5 4.9 9.7 1.3 11.2 6.2 2.5 2.2 7.5 3.2 11.5 10.8 3.9 2.6 15.1 8.2 12.6 2.9 9.1 34.7 8.3 17.8 12.7 26.1 4.4 25.1 1.1 15.9 11.2 16.8 7.5 3.3 10.3 1.9 1.1 1.4 1.5 1.2 1.2 2.1 1.0 0.6 0.8 7.4 3.1 0.7 3.3 0.9 2.0 3.0 3.6 5.0 4.4 3.1 1.8 2.8 2.7 3.5 2.9 GATD1 "FLJ34283, PDDC1" ENSG00000177225 "Glutamine amidotransferase like class 1 domain containing 1" Q8NB37 11 767220-777488 "Enzymes, Predicted intracellular proteins, Predicted secreted proteins" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HEK 293: 49.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA008812 Uncertain Supported Nucleoplasm "Secreted - unknown location" Nucleoplasm "HPA008812: AB_10962724" "unprognostic (3.39e-1)" "unprognostic (2.48e-2)" "unprognostic (1.31e-1)" "unprognostic (3.58e-2)" "unprognostic (2.82e-2)" "unprognostic (3.03e-2)" "prognostic unfavourable (3.98e-4)" "unprognostic (3.50e-2)" "unprognostic (2.19e-1)" "unprognostic (5.67e-2)" "unprognostic (5.23e-3)" "unprognostic (4.89e-3)" "prognostic favourable (3.79e-5)" "unprognostic (2.84e-2)" "unprognostic (8.40e-2)" "unprognostic (6.11e-2)" "unprognostic (6.61e-3)" 16.7 36.5 26.6 16.3 24.9 10.6 19.1 30.9 29.8 15.1 15.0 20.7 19.8 23.3 17.7 22.4 16.6 18.8 20.0 16.7 27.0 26.2 19.8 18.6 15.3 15.6 25.8 19.4 21.9 16.6 15.5 22.9 16.4 22.0 18.6 10.5 15.8 20.0 23.8 19.2 27.2 21.5 12.6 21.7 17.2 19.1 17.5 21.5 12.8 17.0 13.0 11.5 11.9 14.3 4.0 9.5 1.3 8.7 1.7 4.7 2.8 16.5 9.6 9.3 9.9 4.3 6.7 9.0 9.9 4.3 9.2 8.1 6.9 26.0 9.0 3.6 6.5 17.8 6.9 8.8 4.6 11.5 49.8 5.5 14.4 14.5 7.5 10.3 11.8 9.5 9.8 3.9 6.0 7.0 13.5 8.3 5.1 4.8 11.6 11.1 8.8 17.7 12.8 6.3 11.3 8.0 3.7 24.0 9.4 9.6 13.6 6.7 11.8 6.8 12.8 9.9 7.5 5.3 7.6 10.0 5.0 11.5 15.0 13.8 8.0 1.3 7.0 1.3 4.7 8.7 3.4 4.0 4.5 4.4 9.5 3.5 3.9 2.6 0.7 1.7 3.5 5.5 2.1 2.8 26.6 24.9 30.9 27.7 27.0 26.2 25.8 19.4 22.0 21.5 GGH ENSG00000137563 "Gamma-glutamyl hydrolase" Q92820 8 63015079-63039171 "Enzymes, Plasma proteins, Predicted intracellular proteins" Hydrolase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "kidney: 42.5;liver: 59.5" "Low cell line specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Cell type enriched" "Detected in many" 4 "plasmacytoid DC: 18.2" "Lineage enriched" "Detected in all" 4 "dendritic cells: 18.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB019296, HPA025226" Approved "Intracellular and membrane" 1400000000 "CAB019296: , HPA025226: AB_1849645" "unprognostic (9.29e-2)" "unprognostic (1.22e-1)" "unprognostic (5.48e-3)" "prognostic unfavourable (3.99e-7)" "unprognostic (5.57e-2)" "unprognostic (1.08e-1)" "unprognostic (1.14e-1)" "prognostic unfavourable (1.65e-4)" "unprognostic (1.95e-2)" "unprognostic (1.60e-1)" "unprognostic (2.11e-2)" "unprognostic (1.32e-1)" "unprognostic (1.69e-2)" "unprognostic (9.62e-3)" "unprognostic (1.50e-1)" "unprognostic (2.36e-1)" "unprognostic (6.50e-2)" 3.5 3.6 7.4 4.7 8.6 12.3 11.8 15.5 9.9 3.5 17.6 1.5 1.0 3.7 2.6 3.7 11.0 1.6 2.8 5.9 7.9 7.6 42.5 59.5 3.5 5.0 4.7 7.0 1.9 4.2 1.0 1.6 17.7 14.8 1.9 26.4 2.2 6.5 1.8 1.7 11.1 3.6 4.2 7.6 3.7 3.2 14.0 3.8 5.2 1.4 14.5 7.6 3.9 6.6 4.1 18.2 2.1 1.9 2.9 1.4 1.4 20.4 19.7 20.2 3.1 19.9 8.4 14.9 12.6 21.6 20.0 29.1 27.5 36.3 14.0 3.6 15.6 17.1 20.0 21.1 29.8 28.4 15.1 23.0 10.6 18.6 3.8 10.7 13.8 6.1 6.0 20.2 9.7 24.2 12.2 51.3 37.5 11.6 5.2 10.7 9.5 18.6 15.6 19.7 18.8 15.5 7.2 8.1 13.8 18.4 20.1 19.1 22.2 11.9 12.8 21.6 24.2 20.7 22.7 24.0 24.4 16.4 33.4 0.0 38.1 0.0 1.9 2.1 1.1 1.1 0.5 4.1 1.3 1.3 0.6 1.9 1.0 1.3 1.8 2.9 1.2 18.2 1.4 1.4 7.4 8.6 15.5 9.9 7.9 7.6 4.7 7.0 14.8 3.8 GZMA "CTLA3, HFSP" ENSG00000145649 "Granzyme A" P12544 5 55102648-55110252 "Enzymes, Predicted secreted proteins" "Apoptosis, Cytolysis" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 5 "blood: 92.3;intestine: 31.0;lymphoid tissue: 40.9" "Cell line enriched" "Detected in some" 4 "HL-60: 9.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Group enriched" "Detected in many" 13 "gdT-cell: 92.3;MAIT T-cell: 90.8;memory CD4 T-cell: 25.4;memory CD8 T-cell: 89.3;naive CD8 T-cell: 50.5;NK-cell: 61.9" "Group enriched" "Detected in many" 38 "NK-cells: 61.9;T-cells: 92.3" "Not detected" "Not detected" "Low region specificity" "Detected in all" HPA054134 Approved "Secreted to blood" "HPA054134: " "prognostic favourable (7.27e-4)" "unprognostic (7.29e-3)" "unprognostic (1.50e-2)" "prognostic favourable (6.44e-6)" "unprognostic (2.96e-3)" "unprognostic (1.85e-3)" "unprognostic (8.30e-3)" "unprognostic (1.15e-2)" "unprognostic (5.15e-3)" "unprognostic (3.03e-2)" "unprognostic (1.77e-1)" "unprognostic (3.09e-1)" "prognostic unfavourable (1.26e-6)" "unprognostic (5.91e-2)" "unprognostic (5.57e-1)" "unprognostic (5.73e-3)" "unprognostic (3.33e-3)" 4.3 1.8 1.1 16.3 1.2 10.0 2.5 0.7 0.8 3.9 12.5 0.9 1.3 10.3 5.2 2.9 2.9 2.9 9.6 4.5 1.1 1.1 4.6 5.2 11.8 20.3 1.7 0.9 3.0 5.8 0.0 1.9 5.8 1.5 3.4 6.3 4.5 5.1 1.3 2.6 1.2 31.0 2.5 2.6 40.9 3.9 1.1 0.6 1.9 3.1 4.2 11.1 6.6 2.9 0.2 0.2 2.0 0.3 61.9 92.3 52.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 9.1 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.0 2.1 0.1 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.5 0.0 0.2 0.1 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.2 0.2 0.3 92.3 0.2 90.8 0.2 25.4 89.3 0.2 0.1 5.2 50.5 2.0 61.9 0.3 0.2 2.9 52.0 1.1 1.2 0.7 0.8 1.1 1.1 1.7 0.9 1.5 0.6 GZMB "CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, HLP, SECT" ENSG00000100453 "Granzyme B" P10144 14 24630954-24634267 "Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Apoptosis, Cytolysis" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 9 "blood: 298.5" "Cell line enriched" "Detected in some" 5 "HMC-1: 20.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in some" "Cell type enriched" "Detected in many" 5 "plasmacytoid DC: 298.5" "Lineage enriched" "Detected in many" 5 "dendritic cells: 298.5" "CAB000376, HPA003418" Enhanced "Secreted to blood" "CAB000376: AB_323716, HPA003418: AB_1079020" "prognostic favourable (7.27e-4)" "unprognostic (2.82e-3)" "unprognostic (8.54e-2)" "prognostic favourable (1.58e-5)" "unprognostic (2.07e-3)" "unprognostic (1.48e-3)" "unprognostic (4.43e-2)" "unprognostic (8.25e-2)" "unprognostic (3.70e-2)" "unprognostic (3.05e-3)" "unprognostic (4.26e-2)" "unprognostic (1.58e-1)" "prognostic unfavourable (1.10e-7)" "unprognostic (1.24e-1)" "unprognostic (1.48e-1)" "unprognostic (1.29e-1)" "unprognostic (2.71e-3)" 6.4 0.7 0.8 8.0 1.1 26.4 3.2 0.7 0.7 1.6 3.0 0.5 1.3 0.8 3.9 1.5 4.0 1.0 3.1 4.8 0.7 2.4 2.1 5.7 21.7 16.7 1.1 0.0 1.4 0.7 0.0 1.0 7.5 0.8 2.6 0.9 4.0 2.7 2.3 3.5 0.6 2.9 1.8 1.5 33.0 3.5 0.9 0.4 6.1 4.4 5.3 16.8 6.0 1.5 0.2 298.5 2.0 0.2 19.9 60.5 53.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 20.7 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.7 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.2 0.0 0.1 0.1 0.0 0.0 3.8 0.0 0.0 0.0 0.7 2.9 0.3 0.1 0.2 60.5 0.1 0.7 0.2 4.6 28.4 0.2 0.1 1.4 28.7 2.0 19.9 0.2 298.5 0.1 53.6 0.8 1.1 0.7 0.7 0.7 2.4 1.1 0.0 0.8 0.4 GZMH "CCP-X, CGL-2, CSP-C, CTLA1, CTSGL2" ENSG00000100450 "Granzyme H" P20718 14 24606480-24609699 "Enzymes, Predicted secreted proteins" Cytolysis "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 6 "blood: 134.9" "Cell line enhanced" "Detected in some" "Hep G2: 1.5;RPMI-8226: 2.0;THP-1: 1.4;U-266/70: 4.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Group enriched" "Detected in many" 6 "gdT-cell: 134.9;memory CD4 T-cell: 41.8;memory CD8 T-cell: 109.7;naive CD8 T-cell: 102.7" "Lineage enriched" "Detected in many" 8 "T-cells: 134.9" "Low region specificity" "Detected in all" HPA029200 Enhanced "Secreted to blood" "HPA029200: AB_10602908" "unprognostic (3.72e-3)" "unprognostic (1.47e-3)" "unprognostic (5.35e-2)" "prognostic favourable (2.00e-6)" "unprognostic (8.80e-2)" "unprognostic (1.65e-3)" "unprognostic (2.08e-3)" "unprognostic (1.13e-1)" "unprognostic (1.62e-2)" "unprognostic (4.41e-2)" "unprognostic (1.14e-1)" "unprognostic (2.68e-1)" "prognostic unfavourable (1.74e-6)" "unprognostic (1.23e-1)" "unprognostic (1.80e-1)" "unprognostic (3.35e-2)" "unprognostic (2.77e-3)" 3.6 3.1 1.1 5.0 1.2 16.5 3.6 0.5 1.0 1.9 3.1 0.4 0.2 0.9 1.0 2.7 2.6 1.8 8.1 4.8 1.0 1.1 1.7 3.6 16.4 11.5 2.6 1.3 3.0 1.1 0.0 3.7 1.6 1.2 4.5 1.1 5.1 5.4 4.2 4.5 0.8 2.2 2.0 3.1 22.6 2.5 2.5 0.7 0.2 2.5 3.4 6.4 5.1 1.9 0.4 3.2 1.8 0.3 17.6 134.9 82.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.5 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 1.4 0.0 0.0 0.0 0.0 0.0 4.5 0.0 0.1 0.0 0.4 0.9 1.8 0.2 0.1 134.9 0.2 2.4 0.4 41.8 109.7 0.2 0.2 13.9 102.7 1.5 17.6 0.3 3.2 0.3 82.9 1.1 1.2 0.5 1.0 1.0 1.1 2.6 1.3 1.2 0.7 GZMK "PRSS, TRYP2" ENSG00000113088 "Granzyme K" P49863 5 55024253-55034570 "Enzymes, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 6 "blood: 95.8;lymphoid tissue: 37.3" "Cell line enhanced" "Detected in single" "U-2197: 1.2" "Low cancer specificity" "Detected in all" "Not detected" "Not detected" "Cell type enhanced" "Detected in many" "MAIT T-cell: 95.8;memory CD8 T-cell: 59.0" "Group enriched" "Detected in many" 191 "NK-cells: 56.9;T-cells: 95.8" "Low region specificity" "Detected in some" "Low region specificity" "Detected in all" HPA063181 Enhanced "Secreted to blood" "HPA063181: " "prognostic favourable (8.68e-4)" "unprognostic (3.26e-3)" "unprognostic (2.23e-2)" "unprognostic (1.83e-3)" "unprognostic (2.61e-2)" "unprognostic (1.12e-3)" "unprognostic (1.03e-3)" "unprognostic (8.13e-3)" "unprognostic (3.50e-2)" "unprognostic (4.53e-2)" "unprognostic (9.74e-2)" "unprognostic (1.96e-1)" "prognostic unfavourable (1.06e-4)" "unprognostic (2.04e-1)" "unprognostic (2.42e-1)" "unprognostic (1.21e-2)" "unprognostic (1.00e-1)" 3.5 1.6 0.6 10.5 0.6 3.6 3.1 0.5 0.5 4.1 3.7 0.2 1.7 0.4 3.2 2.6 2.8 1.8 7.4 1.6 0.6 0.7 4.3 4.1 10.2 37.3 0.7 0.2 2.1 1.5 0.0 1.0 0.9 0.5 6.6 1.9 2.9 5.7 2.1 0.8 0.8 7.4 0.8 1.6 36.4 2.4 2.1 0.3 3.3 3.1 2.7 28.2 4.9 2.6 0.0 0.1 0.4 0.1 56.9 95.8 9.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.8 0.1 0.0 0.0 0.0 0.0 0.5 0.3 0.0 0.8 0.4 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.2 0.2 0.0 0.0 0.0 0.4 0.0 0.1 0.1 0.1 21.1 0.1 95.8 0.0 13.2 59.0 0.0 0.0 0.6 10.5 0.4 56.9 0.1 0.1 0.8 9.9 0.6 0.6 0.5 0.5 0.6 0.7 0.7 0.2 0.5 0.3 GZMM "LMET1, MET1" ENSG00000197540 "Granzyme M" P51124 19 544034-549924 "Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Apoptosis, Cytolysis, Immunity, Innate immunity" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "blood: 79.2;lymphoid tissue: 28.6" "Cell line enhanced" "Detected in some" "EFO-21: 5.2;HDLM-2: 4.2;HMC-1: 5.3;MOLT-4: 3.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in some" "Cell type enhanced" "Detected in many" "gdT-cell: 79.2" "Group enriched" "Detected in many" 31 "NK-cells: 22.7;T-cells: 79.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" HPA015624 Enhanced "Secreted to blood" "HPA015624: " "unprognostic (2.97e-3)" "unprognostic (2.29e-3)" "unprognostic (7.53e-2)" "prognostic favourable (1.89e-4)" "unprognostic (1.07e-1)" "prognostic favourable (1.87e-7)" "unprognostic (2.35e-1)" "unprognostic (7.46e-2)" "unprognostic (1.67e-1)" "unprognostic (4.98e-2)" "unprognostic (4.53e-2)" "unprognostic (7.94e-2)" "prognostic unfavourable (1.21e-4)" "unprognostic (1.32e-1)" "unprognostic (9.51e-2)" "unprognostic (2.69e-3)" "unprognostic (9.94e-2)" 1.8 1.0 0.7 13.6 0.9 15.6 1.0 4.3 1.4 1.0 3.5 0.2 0.1 1.8 1.0 2.9 2.0 1.1 4.7 1.6 0.7 0.6 1.1 2.6 4.8 15.1 0.7 0.4 0.8 0.4 0.0 0.9 1.6 0.5 1.7 0.1 1.5 12.0 0.3 0.8 0.7 5.1 0.5 1.1 21.1 3.0 1.5 0.4 28.6 1.4 1.1 10.9 1.1 1.2 0.4 0.4 1.6 0.2 22.7 79.2 27.0 0.1 0.7 0.1 0.3 0.2 0.0 0.7 0.0 0.1 0.1 0.0 0.6 0.2 0.1 5.2 0.0 0.1 0.0 0.0 0.0 4.2 0.4 0.0 0.6 0.2 0.6 0.4 5.3 0.2 0.0 0.1 0.0 0.1 1.6 0.3 0.0 1.2 3.4 1.4 0.9 0.8 0.3 0.0 0.0 0.0 0.3 0.1 0.2 0.0 0.0 0.4 0.0 0.1 0.0 0.0 0.8 0.9 0.0 1.1 0.4 1.1 0.3 0.8 0.3 0.8 0.1 0.1 79.2 0.2 49.8 0.1 26.4 63.6 0.1 0.4 25.8 53.1 1.6 22.7 0.2 0.4 12.2 27.0 0.7 0.9 4.3 1.4 0.7 0.6 0.7 0.4 0.5 0.4 HABP2 "FSAP, HABP, HGFAL, PHBP" ENSG00000148702 "Hyaluronan binding protein 2" Q14520 10 113550837-113589602 "Candidate cardiovascular disease genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 5 "liver: 135.4" "Cell line enriched" "Detected in some" 6 "RPTEC TERT1: 33.3" "Cancer enriched" "Detected in many" 5 "liver cancer: 92.4" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA019518 Uncertain "Secreted to blood" 20206666667 3200000000 "HPA019518: AB_1850467" "unprognostic (3.89e-2)" "unprognostic (6.15e-2)" "unprognostic (1.33e-1)" "unprognostic (1.24e-1)" "unprognostic (1.45e-1)" "unprognostic (6.92e-2)" "unprognostic (1.01e-1)" "unprognostic (5.86e-3)" "unprognostic (1.67e-1)" "unprognostic (9.78e-2)" "unprognostic (5.10e-2)" "unprognostic (4.77e-2)" "unprognostic (9.18e-3)" "unprognostic (2.62e-3)" "unprognostic (2.11e-1)" "unprognostic (3.22e-1)" "unprognostic (9.05e-3)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.1 0.0 0.0 0.6 0.6 0.3 0.0 0.4 26.4 0.4 0.0 0.0 20.9 135.4 0.2 0.0 0.0 0.0 0.8 11.6 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.2 0.0 0.0 0.1 2.6 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.7 0.0 0.0 1.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 33.3 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 HGF "DFNB39, F-TCF, HGFB, HPTA, SF" ENSG00000019991 "Hepatocyte growth factor" P14210 7 81699008-81770438 "Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted secreted proteins, RAS pathway related proteins" "Growth factor, Serine protease homolog" "Cancer-related genes, Deafness, Non-syndromic deafness" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "placenta: 116.9" "Cell line enhanced" "Detected in some" "ASC TERT1: 44.8;HHSteC: 35.1;HL-60: 19.6;hTEC/SVTERT24-B: 22.0;Karpas-707: 60.7;U-87 MG: 16.1" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Cell type enriched" "Detected in many" 4 "basophil: 33.5" "Lineage enriched" "Detected in many" 4 "granulocytes: 33.5" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" "CAB010333, HPA040360, HPA044088" Approved Approved Centrosome,Cytosol "Secreted to blood" Cytosol Centrosome "CAB010333: AB_647965, HPA040360: , HPA044088: " "unprognostic (5.24e-2)" "unprognostic (6.77e-2)" "unprognostic (1.72e-2)" "unprognostic (5.12e-2)" "unprognostic (1.85e-2)" "unprognostic (7.45e-5)" "unprognostic (1.66e-1)" "unprognostic (9.28e-3)" "unprognostic (3.28e-2)" "unprognostic (2.97e-2)" "unprognostic (2.74e-1)" "unprognostic (5.29e-2)" "prognostic unfavourable (5.59e-4)" "unprognostic (7.90e-3)" "unprognostic (2.92e-2)" "unprognostic (1.14e-2)" "unprognostic (2.06e-2)" 6.2 10.6 1.4 2.9 1.2 4.6 4.8 0.5 4.5 5.1 4.0 0.4 2.9 1.5 5.2 3.1 2.9 4.0 7.1 9.3 3.6 1.3 7.3 27.5 15.8 2.0 1.3 1.4 3.2 1.4 1.6 4.3 116.9 1.9 10.8 1.9 2.0 2.2 3.2 1.4 0.9 1.8 15.1 6.0 6.6 2.3 2.0 0.9 0.5 5.3 1.4 1.4 10.5 21.5 0.0 2.0 33.5 7.6 0.0 0.0 1.5 0.0 0.0 0.0 0.0 5.5 44.8 0.0 0.1 8.3 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 1.4 0.0 0.0 35.1 19.6 0.1 10.6 0.0 22.0 0.0 0.5 0.0 60.7 0.1 0.0 0.0 13.6 0.0 0.0 0.2 0.0 1.8 0.0 0.0 0.0 2.3 0.0 0.0 0.0 0.0 0.8 0.1 0.5 0.0 0.0 0.0 0.0 0.0 0.0 16.1 4.1 0.0 33.5 6.6 1.6 0.0 7.6 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 1.3 0.0 6.7 0.4 0.0 1.5 1.4 1.2 0.5 4.5 3.6 1.3 1.3 1.4 1.9 0.9 HGFAC "HGFA, HGFAP" ENSG00000109758 "HGF activator" Q04756 4 3441887-3449495 "Cancer-related genes, Enzymes, Plasma proteins, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 141 "liver: 128.0" "Cell line enriched" "Detected in some" 8 "Hep G2: 10.7" "Cancer enriched" "Detected in some" 22 "liver cancer: 26.7" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in all" "HPA058279, HPA059076" Enhanced "Secreted to blood" 7586667 11000000000 "HPA058279: AB_2683665, HPA059076: AB_2683898" "unprognostic (2.70e-2)" "unprognostic (8.20e-2)" "unprognostic (1.57e-1)" "unprognostic (1.86e-1)" "unprognostic (1.36e-1)" "unprognostic (1.39e-2)" "unprognostic (2.85e-3)" "unprognostic (5.37e-3)" "unprognostic (5.90e-2)" "unprognostic (1.81e-1)" "unprognostic (8.54e-3)" "unprognostic (5.52e-2)" "prognostic unfavourable (9.31e-4)" "unprognostic (2.87e-1)" "unprognostic (2.24e-1)" "unprognostic (9.49e-2)" "unprognostic (3.74e-4)" 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.4 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.1 0.0 0.0 0.1 0.0 0.1 128.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.0 0.2 0.0 0.1 0.1 0.0 0.0 0.0 0.4 0.5 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 10.7 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.6 0.2 1.2 0.7 0.4 0.1 0.0 0.0 0.6 1.1 0.0 0.0 0.3 0.1 0.0 0.0 0.5 0.7 0.0 0.1 0.3 0.3 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.1 0.4 0.1 0.1 0.0 0.0 0.0 0.1 0.0 HM13 "dJ324O17.1, H13, IMP1, IMPAS, PSENL3, PSL3, SPP, SPPL1" ENSG00000101294 "Histocompatibility minor 13" Q8TCT9 20 31514428-31577923 "Enzymes, Plasma proteins, Predicted membrane proteins" "Hydrolase, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA045089, HPA056062" Enhanced Supported "Endoplasmic reticulum" "Endoplasmic reticulum" "HPA045089: AB_10962054, HPA056062: " "unprognostic (8.03e-2)" "unprognostic (2.11e-2)" "unprognostic (5.03e-2)" "unprognostic (1.59e-1)" "unprognostic (2.82e-1)" "unprognostic (5.87e-3)" "prognostic unfavourable (1.95e-5)" "unprognostic (2.66e-2)" "unprognostic (2.14e-2)" "unprognostic (2.55e-1)" "unprognostic (2.30e-1)" "unprognostic (8.10e-2)" "prognostic unfavourable (4.64e-12)" "unprognostic (3.77e-2)" "unprognostic (1.57e-1)" "unprognostic (1.85e-1)" "unprognostic (8.17e-2)" 25.2 34.3 9.2 20.1 11.1 19.8 36.4 10.2 17.5 37.9 17.0 13.2 64.7 18.1 23.3 40.7 39.2 21.4 24.1 17.9 9.3 13.0 30.2 121.3 25.5 38.7 10.8 9.8 20.8 132.3 24.4 28.6 45.9 14.5 22.4 16.3 15.4 149.6 84.3 13.1 15.0 17.8 17.9 11.0 22.0 25.3 11.7 9.0 15.5 33.5 21.5 30.5 18.1 21.4 16.7 48.2 50.1 65.3 19.4 29.8 52.6 24.6 26.0 10.5 15.5 47.9 30.8 36.2 42.2 39.5 28.9 29.8 51.6 29.7 15.9 56.9 46.0 45.1 14.7 28.4 19.0 8.0 19.9 35.2 19.0 31.0 53.3 20.0 14.1 28.1 18.5 24.4 33.4 22.3 15.5 63.3 26.7 29.1 17.1 14.4 12.1 44.6 10.9 49.5 74.2 27.8 13.2 13.8 16.7 43.2 41.6 34.1 32.3 19.1 27.0 43.9 23.4 44.2 23.7 40.9 24.3 12.6 59.9 72.2 38.7 18.4 65.3 31.8 21.7 64.0 29.8 16.7 20.5 20.9 46.0 12.6 13.8 16.2 50.1 19.4 58.6 48.2 18.1 52.6 9.2 11.1 10.2 17.5 9.3 13.0 10.8 9.8 14.5 9.0 HP ENSG00000257017 Haptoglobin P00738 16 72054592-72061055 "Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins" "Acute phase, Immunity" "Antibiotic, Antimicrobial, Antioxidant, Serine protease homolog" "Cancer-related genes, Disease mutation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 37 "liver: 1156.9" "Group enriched" "Detected in some" 5 "Hep G2: 64.7;HSkMC: 37.1" "Cancer enriched" "Detected in many" 81 "liver cancer: 1297.4" "Not detected" "Not detected" "Group enriched" "Detected in some" 4 "classical monocyte: 20.0;eosinophil: 30.9" "Group enriched" "Detected in many" 7 "granulocytes: 30.9;monocytes: 20.0" "CAB003787, HPA047750" Enhanced Approved Vesicles "Secreted to blood" 181000000 140000000000 Vesicles "CAB003787: , HPA047750: " "unprognostic (6.38e-3)" "unprognostic (7.73e-3)" "unprognostic (1.23e-1)" "unprognostic (2.41e-2)" "unprognostic (2.34e-3)" "unprognostic (2.07e-1)" "unprognostic (7.79e-3)" "unprognostic (1.37e-1)" "unprognostic (2.31e-1)" "unprognostic (1.84e-1)" "unprognostic (6.30e-2)" "unprognostic (8.18e-2)" "prognostic unfavourable (6.94e-13)" "unprognostic (4.34e-4)" "unprognostic (1.80e-1)" "unprognostic (6.61e-2)" "unprognostic (2.49e-2)" 9.8 0.0 0.3 0.4 0.3 4.4 0.3 0.3 0.3 1.5 0.4 0.3 0.3 0.0 0.3 0.5 0.3 1.1 0.3 3.0 0.3 0.0 0.4 1156.9 1.4 0.4 0.3 0.3 0.3 0.5 0.0 0.5 0.3 0.3 0.3 0.0 0.3 0.3 0.3 0.3 0.0 0.3 0.3 0.3 1.4 0.0 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.5 0.0 3.5 30.9 20.0 0.0 0.0 5.0 0.0 0.0 0.0 0.0 2.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 2.4 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 3.3 0.0 64.7 0.1 9.2 1.7 37.1 0.0 0.0 0.0 0.0 2.4 0.0 0.0 0.0 0.5 0.1 0.7 0.0 0.3 6.9 0.0 0.0 0.0 0.0 0.0 4.7 0.0 0.0 0.0 2.1 1.4 0.0 0.2 0.0 0.0 1.2 0.0 4.4 0.0 3.6 0.0 2.6 20.0 30.9 0.0 0.8 0.0 0.0 0.0 0.0 3.5 0.0 0.0 0.0 5.8 0.0 0.9 0.0 0.0 5.0 0.3 0.3 0.3 0.3 0.3 0.0 0.3 0.3 0.3 0.3 HPN TMPRSS1 ENSG00000105707 Hepsin P05981 19 35040506-35066571 "Cancer-related genes, Enzymes, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Protease, Serine protease" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 9 "kidney: 55.4;liver: 146.5;pancreas: 80.1" "Group enriched" "Detected in some" 9 "EFO-21: 19.4;Hep G2: 27.5;T-47d: 13.4" "Cancer enhanced" "Detected in many" "liver cancer: 127.5" "Low region specificity" "Detected in single" "Cell type enhanced" "Detected in some" "memory CD8 T-cell: 1.2;naive CD8 T-cell: 1.2" "Lineage enriched" "Detected in single" 5 "T-cells: 1.2" "Low region specificity" "Detected in single" "Low region specificity" "Detected in all" HPA006804 Approved 1000000 "HPA006804: AB_1079046" "unprognostic (6.74e-3)" "unprognostic (6.00e-2)" "unprognostic (4.10e-2)" "unprognostic (1.16e-1)" "unprognostic (2.72e-1)" "unprognostic (9.96e-2)" "unprognostic (4.22e-3)" "unprognostic (1.27e-1)" "unprognostic (4.13e-3)" "unprognostic (9.54e-2)" "unprognostic (3.54e-1)" "unprognostic (1.16e-1)" "prognostic favourable (5.45e-5)" "unprognostic (1.22e-1)" "unprognostic (1.52e-1)" "unprognostic (1.12e-1)" "unprognostic (7.96e-2)" 0.2 0.0 0.3 0.1 0.5 0.0 3.2 0.4 1.1 0.3 0.3 0.2 8.4 0.2 1.1 10.7 0.1 1.9 3.2 0.7 0.6 0.3 55.4 146.5 4.9 0.1 0.9 0.2 0.4 80.1 2.6 3.2 0.2 0.4 5.3 0.0 0.4 4.1 8.5 8.5 0.0 0.2 0.1 0.9 0.3 6.9 0.8 0.3 0.1 4.3 0.4 0.2 0.3 0.1 0.2 0.2 0.0 0.1 0.0 1.2 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 2.1 0.0 0.1 19.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 27.5 0.1 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.1 0.2 0.0 0.0 0.0 2.0 0.1 0.1 0.0 0.1 13.4 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.2 0.0 0.1 0.0 1.0 0.0 0.6 0.2 0.5 1.2 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.2 0.0 0.3 0.3 0.5 0.4 1.1 0.6 0.3 0.9 0.2 0.4 0.3 HPR ENSG00000261701 "Haptoglobin-related protein" P00739 16 72063224-72077246 "Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Serine protease homolog" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 10 "liver: 151.4" "Cell line enriched" "Detected in some" 14 "Hep G2: 32.8" "Cancer enriched" "Detected in some" 53 "liver cancer: 185.1" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in many" HPA047750 Supported Approved Vesicles "Secreted to blood" 49000000000 77000000000 Vesicles "HPA047750: " "unprognostic (2.43e-1)" "unprognostic (4.69e-2)" "unprognostic (5.97e-3)" "unprognostic (2.42e-1)" "unprognostic (2.32e-3)" "unprognostic (2.36e-1)" "unprognostic (1.66e-1)" "unprognostic (8.21e-2)" "unprognostic (2.30e-1)" "unprognostic (3.44e-6)" "unprognostic (2.09e-2)" "unprognostic (1.45e-1)" "unprognostic (1.29e-1)" 0.2 0.0 1.3 0.0 1.6 0.0 0.0 0.0 0.6 0.1 0.0 0.1 0.0 0.1 0.0 0.0 0.1 15.2 0.7 0.8 0.1 151.4 0.0 0.1 2.1 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.3 0.0 0.0 0.2 0.0 0.0 0.0 0.0 1.1 2.9 1.1 1.0 0.4 2.3 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 32.8 1.5 0.0 0.0 2.3 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.8 1.1 1.3 1.0 0.1 0.5 0.4 0.4 0.3 1.1 2.0 1.1 0.3 0.4 0.3 2.9 2.3 0.3 HTRA1 "ARMD7, HtrA, IGFBP5-protease, PRSS11" ENSG00000166033 "HtrA serine peptidase 1" Q92743 10 122461525-122514908 "Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins" "Growth factor binding, Hydrolase, Protease, Serine protease" "Age-related macular degeneration, Disease mutation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell line enhanced" "Detected in many" "ASC diff: 198.9;ASC TERT1: 73.9;fHDF/TERT166: 67.4;HSkMC: 129.7;LHCN-M2: 98.6;U-87 MG: 81.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Cell type enhanced" "Detected in some" "classical monocyte: 2.4;memory CD4 T-cell: 1.6" "Group enriched" "Detected in many" 20 "monocytes: 2.4;T-cells: 1.6" "Low region specificity" "Detected in all" HPA036655 Approved Supported "Plasma membrane" "Secreted to blood" 24800000 2600000 "Plasma membrane" "HPA036655: AB_10671966" "unprognostic (3.84e-1)" "unprognostic (3.42e-2)" "unprognostic (1.57e-2)" "unprognostic (1.86e-2)" "unprognostic (1.22e-3)" "unprognostic (8.71e-3)" "unprognostic (2.33e-2)" "unprognostic (3.83e-1)" "unprognostic (7.22e-2)" "unprognostic (3.36e-2)" "unprognostic (1.32e-1)" "unprognostic (1.54e-1)" "prognostic unfavourable (7.90e-7)" "unprognostic (7.12e-3)" "unprognostic (9.13e-2)" "unprognostic (1.69e-1)" "prognostic unfavourable (5.62e-6)" 40.8 21.8 64.5 9.1 79.0 0.5 48.2 16.2 62.8 50.4 19.3 60.8 7.2 5.6 47.6 67.0 15.6 19.5 78.7 28.7 50.8 35.4 34.7 60.4 14.6 9.1 62.7 32.5 111.3 14.5 37.6 26.9 114.1 41.9 19.5 14.0 20.7 19.3 31.5 7.5 29.6 9.3 40.5 46.5 10.5 12.9 9.8 49.5 1.7 13.3 8.5 7.1 41.5 27.3 0.0 0.0 0.0 2.4 0.0 1.6 0.7 0.0 3.4 1.5 0.4 198.9 73.9 0.0 8.5 15.6 3.5 1.9 0.0 0.0 0.0 2.3 67.4 1.0 0.6 9.7 0.5 0.0 0.3 0.0 5.7 0.0 10.1 0.0 0.0 129.7 35.7 2.0 16.6 16.3 0.0 0.1 98.6 1.7 0.0 0.0 1.6 5.4 0.0 0.1 0.0 22.5 0.1 0.1 0.3 21.4 0.0 9.2 0.6 0.0 10.7 25.1 0.3 11.3 7.2 0.0 0.0 0.0 81.4 0.0 11.7 0.0 2.4 0.0 0.6 0.0 0.4 0.0 1.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 64.5 79.0 16.2 54.6 50.8 35.4 62.7 32.5 41.9 49.5 HTRA2 "OMI, PARK13, PRSS25" ENSG00000115317 "HtrA serine peptidase 2" O43464 2 74529377-74533348 "Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted membrane proteins" Apoptosis "Hydrolase, Protease, Serine protease" "Disease mutation, Epilepsy, Neurodegeneration, Parkinson disease, Parkinsonism" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004004, HPA006602, HPA027366" Uncertain Supported Mitochondria Mitochondria "CAB004004: AB_326421, HPA006602: , HPA027366: AB_1851301" "unprognostic (3.09e-1)" "unprognostic (4.06e-2)" "unprognostic (2.82e-1)" "unprognostic (2.58e-2)" "unprognostic (1.56e-1)" "unprognostic (1.37e-1)" "prognostic unfavourable (7.77e-8)" "unprognostic (2.12e-3)" "unprognostic (4.18e-1)" "unprognostic (1.15e-1)" "unprognostic (4.57e-2)" "unprognostic (8.15e-2)" "unprognostic (7.23e-3)" "unprognostic (4.03e-1)" "unprognostic (1.73e-1)" "unprognostic (1.72e-1)" "unprognostic (2.06e-2)" 16.4 12.7 10.6 14.9 11.3 18.9 12.9 10.7 17.7 12.3 12.8 12.6 9.7 12.6 12.9 6.9 10.7 10.6 9.0 12.9 11.6 8.7 13.1 11.4 11.3 13.2 10.8 11.9 18.7 12.9 10.5 9.0 10.4 13.5 11.6 5.5 10.2 13.1 9.2 17.6 9.0 12.6 11.8 9.1 17.3 11.8 13.9 12.6 12.2 16.8 12.6 9.3 10.4 15.2 12.9 9.4 5.9 8.1 5.5 7.8 7.0 7.9 4.9 5.7 4.9 7.9 3.2 15.2 6.9 3.6 4.2 2.4 9.1 3.5 7.2 5.4 3.9 9.0 6.7 7.9 1.1 16.2 13.4 14.4 4.7 8.0 7.4 6.7 10.6 3.8 5.3 7.9 6.7 5.2 18.9 10.7 3.1 5.2 12.4 14.2 4.7 14.2 8.5 16.1 7.9 3.4 3.2 6.6 7.9 3.7 8.5 13.2 3.9 6.6 3.7 7.3 9.0 14.7 15.4 13.1 4.3 4.7 6.3 10.7 5.8 5.9 8.1 4.8 7.3 6.2 7.8 12.9 7.3 6.2 9.4 11.6 6.3 6.4 3.2 5.5 4.7 6.6 7.4 7.0 10.6 11.3 10.7 17.7 11.6 8.7 10.8 11.9 13.5 12.6 HTRA3 "Prsp, Tasp" ENSG00000170801 "HtrA serine peptidase 3" P83110 4 8269765-8307111 "Enzymes, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "heart muscle: 57.9" "Cell line enriched" "Detected in some" 5 "U-2197: 62.8" "Low cancer specificity" "Detected in all" "Region enriched" "Detected in single" 9 "basal ganglia: 8.2" "Cell type enhanced" "Detected in single" "neutrophil: 1.3" "Low lineage specificity" "Detected in single" "Low region specificity" "Detected in all" "Low region specificity" "Detected in single" "HPA021187, HPA063810" Approved Approved Vesicles "Secreted in female reproductive system" Vesicles "HPA021187: AB_1851311, HPA063810: " "unprognostic (5.87e-2)" "unprognostic (1.40e-2)" "unprognostic (2.89e-2)" "unprognostic (9.32e-2)" "unprognostic (1.84e-1)" "unprognostic (3.09e-2)" "unprognostic (1.12e-3)" "unprognostic (5.29e-2)" "unprognostic (3.81e-2)" "unprognostic (1.15e-1)" "unprognostic (1.95e-2)" "unprognostic (2.79e-1)" "prognostic unfavourable (1.61e-9)" "unprognostic (1.65e-3)" "unprognostic (2.56e-2)" "prognostic unfavourable (1.29e-4)" "unprognostic (1.34e-2)" 23.7 1.8 0.6 7.3 8.2 5.3 35.6 0.7 0.9 12.3 9.4 0.8 5.4 3.7 19.6 26.6 14.4 7.9 19.8 57.9 0.7 0.3 1.7 1.6 15.4 4.3 0.8 0.9 30.7 2.8 0.0 5.1 9.6 0.9 15.4 2.0 8.6 6.6 3.0 12.9 9.0 6.7 50.1 0.8 1.8 6.8 7.2 0.6 1.3 9.3 11.6 3.0 28.7 12.7 0.0 0.4 1.3 0.3 0.0 0.0 0.1 0.0 0.3 0.4 0.0 2.0 3.8 0.1 0.8 0.0 0.9 0.2 0.0 0.0 0.0 4.7 2.1 0.0 0.4 0.0 0.3 0.0 0.7 0.4 4.9 0.0 2.1 0.0 0.2 0.4 0.0 1.4 0.0 3.3 0.1 0.0 3.5 0.0 0.0 12.0 2.1 0.1 0.1 0.0 0.0 0.0 0.0 5.5 0.1 8.9 0.1 0.0 0.0 0.3 2.7 0.5 1.6 62.8 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 1.3 0.0 0.2 0.0 0.0 0.1 0.6 8.2 0.7 0.9 0.7 0.3 0.8 0.9 0.9 0.6 HTRA4 FLJ90724 ENSG00000169495 "HtrA serine peptidase 4" P83105 8 38974164-38988662 "Enzymes, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 13 "placenta: 55.2" "Cell line enriched" "Detected in single" 134 "BEWO: 71.1" "Cancer enhanced" "Detected in some" "testis cancer: 2.5" "Not detected" "Not detected" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Region enhanced" "Detected in some" "hippocampal formation: 2.3" "Low region specificity" "Detected in all" HPA045402 Enhanced "Secreted in female reproductive system" "HPA045402: " "unprognostic (1.20e-1)" "unprognostic (5.83e-4)" "unprognostic (8.02e-2)" "unprognostic (2.13e-2)" "unprognostic (8.20e-2)" "unprognostic (2.42e-2)" "unprognostic (1.80e-1)" "unprognostic (7.40e-3)" "unprognostic (1.40e-1)" "unprognostic (5.14e-4)" "unprognostic (1.01e-1)" "unprognostic (8.68e-2)" "unprognostic (1.42e-1)" "unprognostic (4.58e-1)" "unprognostic (5.19e-3)" "unprognostic (2.39e-3)" "unprognostic (1.19e-3)" 2.6 1.1 0.2 0.3 0.2 3.4 0.9 0.2 0.4 1.2 0.5 0.2 1.9 0.0 2.3 0.5 0.5 0.1 0.2 0.2 0.2 0.0 0.2 0.2 4.3 1.0 0.2 0.2 0.4 0.3 0.4 0.5 55.2 0.4 0.5 0.3 1.8 0.8 0.5 0.6 0.4 0.6 0.3 1.8 2.5 0.1 0.4 0.2 0.2 0.6 0.2 0.8 0.5 0.9 3.1 2.2 2.5 1.0 1.0 1.7 0.0 0.1 0.1 0.1 0.1 0.3 0.2 71.1 0.2 0.1 0.1 0.1 0.1 0.1 0.1 0.0 0.3 0.1 0.1 0.2 0.1 0.0 0.1 0.1 0.1 0.1 0.0 0.2 0.2 0.3 0.1 0.1 0.5 0.1 0.1 0.4 0.2 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.2 0.1 0.2 0.1 0.1 0.0 0.1 0.2 0.0 0.2 0.2 0.1 0.1 0.2 0.0 0.1 0.1 0.3 0.1 1.5 0.8 2.3 1.4 0.7 1.7 1.5 1.3 1.2 0.6 3.1 1.3 1.4 2.5 1.0 1.0 2.2 1.4 0.0 0.2 0.2 0.2 0.4 0.2 0.0 0.2 0.2 0.4 0.2 IDE ENSG00000119912 "Insulin degrading enzyme" P14735 10 92451684-92574076 "Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins" "Host-virus interaction" "Allosteric enzyme, Host cell receptor for virus entry, Hydrolase, Metalloprotease, Protease, Receptor" "FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA063478 Approved "Intracellular and membrane" 140000 "HPA063478: " "unprognostic (1.70e-1)" "unprognostic (6.40e-2)" "prognostic favourable (3.69e-4)" "prognostic favourable (3.53e-4)" "unprognostic (2.54e-1)" "unprognostic (1.78e-1)" "unprognostic (2.51e-1)" "unprognostic (3.79e-1)" "unprognostic (8.88e-2)" "unprognostic (2.57e-1)" "unprognostic (6.58e-2)" "unprognostic (7.79e-2)" "unprognostic (6.81e-2)" "unprognostic (9.24e-3)" "unprognostic (6.13e-2)" "unprognostic (3.89e-2)" "unprognostic (3.91e-1)" 9.8 13.1 6.9 11.7 8.8 6.0 19.8 8.6 9.4 10.5 9.9 6.5 17.5 7.4 10.2 15.9 13.0 8.4 9.6 13.6 5.8 5.3 13.3 21.3 7.9 9.2 8.9 5.1 7.7 15.7 19.4 11.1 9.4 7.6 11.6 10.0 10.5 11.0 17.2 31.1 45.2 10.7 14.3 8.8 9.9 10.3 18.1 7.5 13.5 12.0 13.9 10.7 11.5 9.8 7.4 11.3 3.8 13.7 7.7 10.6 5.5 12.2 18.1 14.1 29.0 13.8 11.6 7.8 10.8 25.7 11.4 9.7 18.4 14.5 17.3 16.0 15.8 15.8 18.6 11.9 7.5 20.7 11.4 8.6 15.1 16.1 12.1 26.2 13.6 8.2 11.6 13.4 19.4 19.2 16.0 12.3 12.9 8.2 8.7 10.3 11.2 7.2 12.1 13.2 11.0 16.8 22.9 6.6 9.2 14.6 10.5 9.5 15.0 7.4 17.8 7.4 8.4 7.7 13.9 11.3 14.1 18.5 10.8 21.0 5.1 2.3 8.2 3.8 6.7 11.4 5.9 7.4 7.9 6.5 11.3 5.3 6.0 6.4 0.5 7.7 13.7 4.4 10.6 5.5 6.9 8.8 8.6 9.4 5.8 5.3 8.9 5.1 7.6 7.5 IMMP1L "FLJ25059, IMMP1" ENSG00000148950 "Inner mitochondrial membrane peptidase subunit 1" Q96LU5 11 31432401-31509645 "Enzymes, Predicted intracellular proteins" "Hydrolase, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" HPA058308 Approved "HPA058308: " "unprognostic (2.39e-1)" "unprognostic (1.20e-2)" "unprognostic (1.12e-1)" "unprognostic (6.17e-2)" "unprognostic (9.67e-2)" "unprognostic (2.08e-2)" "prognostic unfavourable (7.97e-4)" "unprognostic (7.59e-2)" "unprognostic (4.66e-3)" "unprognostic (5.15e-3)" "prognostic favourable (6.72e-4)" "unprognostic (1.97e-1)" "unprognostic (1.07e-2)" "unprognostic (4.66e-1)" "unprognostic (4.52e-2)" "unprognostic (1.37e-2)" "unprognostic (1.04e-3)" 9.1 16.6 25.4 11.6 27.8 8.8 15.4 28.4 18.5 10.0 11.3 11.7 12.8 12.1 9.6 25.6 8.4 7.7 5.1 20.4 21.7 17.4 16.2 11.9 10.7 11.2 16.1 12.1 14.0 23.8 7.2 18.2 8.7 11.4 11.2 8.3 17.4 13.6 12.0 39.8 10.1 10.3 9.3 13.2 7.6 10.8 13.8 12.6 17.6 10.0 13.3 10.8 6.8 7.5 16.4 20.0 14.8 1.7 16.9 21.7 7.8 10.7 15.7 41.7 12.4 5.6 3.8 7.8 14.3 3.2 6.0 4.6 12.0 8.3 11.2 10.0 6.1 12.5 14.3 10.8 9.1 15.1 30.3 13.3 23.5 15.3 6.0 17.3 12.8 3.2 9.7 3.5 7.7 6.4 21.2 13.6 5.7 13.4 21.8 24.9 8.5 13.8 17.2 36.0 10.9 20.4 13.3 11.5 13.2 16.6 8.3 14.2 18.9 17.8 3.0 14.1 14.0 10.9 22.8 12.4 25.7 19.6 18.5 11.8 13.8 9.0 1.7 14.8 15.6 1.6 14.5 16.4 14.0 15.5 4.0 15.0 17.7 21.7 0.3 16.9 1.6 20.0 16.6 7.8 25.4 27.8 28.4 18.5 21.7 17.4 16.1 12.1 11.4 12.6 IMMP2L "IMMP2L-IT1, IMP2" ENSG00000184903 "Inner mitochondrial membrane peptidase subunit 2" Q96T52 7 110663051-111562517 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" HPA026711 Approved Approved Mitochondria Mitochondria "HPA026711: AB_1851760" "unprognostic (2.55e-2)" "unprognostic (1.40e-2)" "unprognostic (4.29e-1)" "unprognostic (1.04e-1)" "unprognostic (3.76e-2)" "prognostic unfavourable (1.89e-5)" "unprognostic (5.64e-3)" "unprognostic (1.00e-1)" "unprognostic (4.17e-1)" "unprognostic (5.68e-3)" "unprognostic (1.12e-1)" "unprognostic (1.09e-1)" "unprognostic (2.89e-3)" "unprognostic (1.32e-1)" "unprognostic (6.65e-2)" "unprognostic (1.79e-1)" "unprognostic (2.71e-1)" 12.4 12.4 7.9 7.3 10.8 2.9 11.8 5.4 9.1 12.4 11.1 5.7 10.6 5.2 23.8 10.4 8.0 11.5 5.8 8.6 7.1 6.0 23.8 17.7 7.4 4.4 5.7 6.1 14.4 10.0 13.4 15.7 8.0 6.3 13.8 5.8 31.6 11.6 15.8 18.6 7.5 10.9 14.4 5.6 5.3 9.8 9.0 5.6 8.2 16.7 8.3 9.5 11.0 9.2 18.1 11.7 5.8 8.4 24.3 15.1 5.1 7.8 4.7 2.8 11.7 7.6 7.7 5.0 5.4 5.5 3.6 3.8 2.3 9.2 12.9 14.9 4.7 4.4 3.0 10.9 6.0 8.0 3.1 4.4 18.7 6.4 11.6 8.1 0.5 13.4 14.5 1.5 10.1 4.7 14.1 10.0 2.7 5.4 10.8 9.1 2.8 7.4 2.3 23.5 6.7 13.2 3.3 3.3 10.4 2.3 11.1 30.0 4.5 4.7 3.0 5.6 5.8 5.6 6.5 5.7 1.5 7.9 6.1 3.8 29.3 5.8 5.1 1.6 6.4 6.4 11.4 16.3 10.8 7.2 9.4 18.1 15.1 10.5 0.2 24.3 8.4 11.7 6.4 5.1 7.9 10.8 5.4 9.1 7.1 6.0 5.7 6.1 6.3 5.6 KEL "CD238, ECE3" ENSG00000197993 "Kell blood group, metallo-endopeptidase" P23276 7 142941114-142962681 "Blood group antigen proteins, Cancer-related genes, CD markers, Enzymes, Predicted intracellular proteins, Predicted membrane proteins" "Blood group antigen, Hydrolase, Metalloprotease, Protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 6 "bone marrow: 21.1;testis: 36.4" "Group enriched" "Detected in some" 12 "HEL: 14.9;K-562: 12.1" "Low cancer specificity" "Detected in some" "Low region specificity" "Detected in some" "Cell type enriched" "Detected in single" 7 "intermediate monocyte: 1.4" "Lineage enriched" "Detected in single" 14 "monocytes: 1.4" "Not detected" "Not detected" "Low region specificity" "Detected in single" HPA064442 Supported "Nucleoplasm,Plasma membrane,Cytosol" "Plasma membrane" "Nucleoplasm, Cytosol" "HPA064442: " "unprognostic (5.78e-3)" "unprognostic (1.08e-5)" "unprognostic (5.29e-3)" "unprognostic (4.85e-3)" "unprognostic (9.68e-2)" "unprognostic (1.96e-2)" "unprognostic (1.03e-1)" "unprognostic (1.54e-2)" "unprognostic (5.18e-2)" "unprognostic (1.08e-2)" "unprognostic (3.71e-2)" "unprognostic (3.57e-2)" "unprognostic (2.29e-3)" "unprognostic (9.24e-2)" "unprognostic (7.05e-2)" "unprognostic (3.32e-2)" "unprognostic (3.25e-3)" 0.2 0.0 0.9 2.5 1.1 21.1 0.2 0.2 0.4 0.4 0.2 0.3 0.2 0.0 0.2 0.2 0.6 0.1 0.2 0.2 1.4 0.7 0.4 0.2 1.4 5.0 2.0 0.2 0.2 0.2 0.0 0.2 1.1 0.3 0.2 0.0 0.3 2.5 0.2 0.2 0.0 0.5 0.2 4.4 3.8 0.0 36.4 0.3 0.4 0.2 0.2 3.7 0.2 0.2 0.0 0.0 0.0 1.4 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 14.9 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 12.1 0.1 0.0 0.0 0.5 0.2 0.3 0.0 0.1 0.0 0.1 0.0 1.1 0.0 0.1 0.1 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.9 1.1 0.2 0.4 1.4 0.7 2.0 0.2 0.3 0.3 KLK1 Klk6 ENSG00000167748 "Kallikrein 1" P06870 19 50819148-50823787 "Enzymes, FDA approved drug targets, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 56 "pancreas: 742.6;salivary gland: 473.0" "Cell line enriched" "Detected in some" 23 "RPMI-8226: 28.8" "Group enriched" "Detected in many" 6 "colorectal cancer: 20.0;pancreatic cancer: 50.9;renal cancer: 84.1" "Not detected" "Not detected" "Group enriched" "Detected in some" 10 "memory B-cell: 10.9;naive B-cell: 3.8" "Lineage enriched" "Detected in single" 14 "B-cells: 10.9" "Secreted to digestive system" 4300000 "unprognostic (1.51e-3)" "unprognostic (1.23e-2)" "unprognostic (4.20e-1)" "unprognostic (1.73e-2)" "unprognostic (1.10e-1)" "unprognostic (8.72e-2)" "unprognostic (1.92e-2)" "unprognostic (7.47e-3)" "unprognostic (1.66e-1)" "unprognostic (2.49e-2)" "unprognostic (8.06e-2)" "unprognostic (2.12e-1)" "unprognostic (1.42e-2)" "unprognostic (2.55e-1)" "unprognostic (6.49e-2)" "unprognostic (2.10e-1)" "unprognostic (6.23e-2)" 0.1 0.2 0.1 0.3 0.1 0.0 0.1 0.1 0.1 0.2 2.5 0.1 0.1 0.2 0.2 0.1 0.1 0.1 0.1 0.1 0.1 0.0 3.8 0.1 0.1 0.1 0.1 0.1 0.1 742.6 0.0 0.1 0.1 0.1 0.2 1.9 0.1 473.0 0.1 0.1 1.8 0.6 0.1 0.1 0.3 0.1 0.1 0.1 0.1 1.2 0.2 0.2 0.1 0.1 10.9 0.7 0.1 0.3 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.6 0.3 0.2 0.2 1.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.4 0.0 0.3 0.1 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 28.8 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.6 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.3 0.0 10.9 0.0 0.0 0.2 3.8 0.0 0.0 0.1 0.0 0.2 0.7 0.0 0.1 0.1 0.1 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.1 KLK10 "NES1, PRSSL1" ENSG00000129451 "Kallikrein related peptidase 10" O43240 19 51012739-51020175 "Cancer-related genes, Enzymes, Predicted secreted proteins" "Cell cycle" "Hydrolase, Protease, Serine protease" "Cancer-related genes, Tumor suppressor" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "esophagus: 78.6;lymphoid tissue: 58.6;tongue: 136.3" "Group enriched" "Detected in some" 6 "CAPAN-2: 52.5;HaCaT: 79.7" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Cell type enhanced" "Detected in single" "neutrophil: 2.1" "Low lineage specificity" "Detected in single" "Region enriched" "Detected in single" 4 "hippocampal formation: 1.7" "Not detected" "Not detected" "Secreted in other tissues" 670000 "prognostic favourable (8.32e-4)" "unprognostic (6.06e-2)" "unprognostic (1.73e-1)" "unprognostic (4.26e-3)" "unprognostic (3.81e-2)" "unprognostic (1.80e-1)" "unprognostic (1.51e-2)" "unprognostic (2.10e-2)" "unprognostic (3.94e-1)" "unprognostic (3.38e-2)" "prognostic unfavourable (6.46e-5)" "unprognostic (2.71e-2)" "unprognostic (2.46e-6)" "unprognostic (9.34e-2)" "unprognostic (7.81e-2)" "unprognostic (2.66e-3)" "unprognostic (1.52e-2)" 1.5 0.5 0.2 1.7 0.3 0.3 2.4 0.7 0.4 20.8 0.9 0.3 0.5 0.2 2.9 0.8 78.6 7.8 36.0 0.7 0.2 0.5 0.2 0.3 4.3 0.2 0.2 0.3 7.2 0.2 0.0 0.2 0.8 0.6 1.6 0.4 0.3 11.0 0.6 0.4 17.7 0.4 0.4 0.4 0.2 0.5 1.6 0.2 1.0 0.3 136.3 58.6 0.5 33.4 0.4 0.5 2.1 0.4 0.4 0.3 0.1 12.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 52.5 0.0 2.9 0.0 79.7 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.2 0.0 0.0 0.0 4.7 0.0 0.0 0.0 0.1 0.0 0.0 0.4 0.0 0.1 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.3 0.2 0.3 0.2 0.3 0.2 0.3 0.2 0.1 0.4 0.3 0.3 2.1 0.4 0.4 0.5 0.3 0.1 0.2 0.3 0.7 0.4 0.2 0.5 0.2 0.3 0.6 0.2 KLK11 "PRSS20, TLSP" ENSG00000167757 "Kallikrein related peptidase 11" Q9UBX7 19 51022216-51028039 "Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "esophagus: 103.4;lymphoid tissue: 88.5;salivary gland: 96.5" "Group enriched" "Detected in some" 4 "EFO-21: 9.4;HaCaT: 29.3" "Low cancer specificity" "Detected in many" "Region enriched" "Detected in single" 11 "pons and medulla: 10.7" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in all" CAB026340 Approved "Secreted in other tissues" 320000 "CAB026340: " "unprognostic (4.23e-2)" "unprognostic (1.50e-2)" "unprognostic (1.27e-1)" "prognostic favourable (3.78e-4)" "unprognostic (2.08e-2)" "unprognostic (4.67e-1)" "unprognostic (5.32e-2)" "unprognostic (3.72e-1)" "unprognostic (3.02e-1)" "prognostic unfavourable (4.17e-4)" "unprognostic (2.92e-2)" "unprognostic (4.16e-6)" "unprognostic (3.90e-2)" "unprognostic (2.73e-1)" "unprognostic (4.40e-2)" "unprognostic (2.53e-1)" 5.5 0.0 0.2 1.1 0.2 0.0 4.9 0.2 0.6 24.5 1.7 2.0 0.4 0.0 5.1 2.7 103.4 9.7 61.8 0.4 0.9 0.0 0.2 0.6 12.3 0.2 0.2 0.2 2.3 25.0 0.0 2.1 0.4 10.7 18.8 0.0 5.1 96.5 1.6 0.3 49.8 0.6 0.3 0.2 0.2 18.7 7.7 0.2 0.9 0.2 65.2 88.5 0.7 33.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 4.5 0.0 9.4 0.0 29.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.3 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.2 0.2 0.6 0.9 0.0 0.2 0.2 10.7 0.2 KLK12 KLK-L5 ENSG00000186474 "Kallikrein related peptidase 12" Q9UKR0 19 51029092-51035230 "Enzymes, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "cervix, uterine: 27.6;esophagus: 53.9;lymphoid tissue: 24.7;tongue: 33.3;vagina: 24.8" "Cell line enhanced" "Detected in some" "CACO-2: 1.2;HaCaT: 2.0" "Cancer enhanced" "Detected in many" "head and neck cancer: 17.7" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in all" CAB025473 Uncertain "Secreted in other tissues" "CAB025473: " "unprognostic (2.84e-1)" "unprognostic (1.41e-1)" "unprognostic (1.08e-3)" "unprognostic (1.15e-1)" "unprognostic (5.80e-3)" "unprognostic (4.99e-3)" "unprognostic (3.18e-1)" "unprognostic (1.41e-1)" "unprognostic (4.64e-2)" "unprognostic (1.51e-1)" "unprognostic (1.56e-1)" "prognostic favourable (8.01e-4)" "unprognostic (8.50e-3)" 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 27.6 2.0 0.0 0.0 3.6 1.2 0.2 53.9 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.3 0.7 0.0 16.6 0.0 0.0 0.4 4.3 0.1 0.2 0.0 0.4 0.5 0.0 0.2 0.0 33.3 24.7 0.0 24.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.3 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.1 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 KLK13 KLK-L4 ENSG00000167759 "Kallikrein related peptidase 13" Q9UKR3 19 51056206-51065114 "Cancer-related genes, Enzymes, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 5 "esophagus: 100.5" "Cell line enriched" "Detected in some" 11 "HaCaT: 20.3" "Cancer enhanced" "Detected in many" "head and neck cancer: 42.3" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA062136 Enhanced "Secreted in other tissues" "HPA062136: " "unprognostic (1.99e-3)" "unprognostic (1.89e-1)" "unprognostic (1.25e-1)" "unprognostic (3.66e-2)" "unprognostic (3.43e-1)" "unprognostic (2.99e-2)" "unprognostic (1.69e-1)" "unprognostic (6.76e-2)" "unprognostic (2.18e-2)" "unprognostic (8.30e-2)" "unprognostic (7.07e-6)" "unprognostic (7.33e-2)" "unprognostic (2.53e-1)" "unprognostic (6.38e-2)" "unprognostic (7.06e-2)" 0.1 0.1 0.1 0.1 0.1 0.0 0.3 0.1 0.2 15.7 0.4 0.2 0.1 0.2 0.3 0.1 100.5 0.2 0.9 0.1 0.1 0.0 0.1 0.1 0.2 0.1 0.1 0.1 0.4 1.7 0.0 0.5 0.1 0.2 0.1 0.0 0.3 12.4 0.1 1.2 2.1 0.4 0.1 0.1 0.1 0.2 6.1 0.1 0.1 0.1 17.9 12.8 0.1 19.4 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.8 0.0 20.3 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.3 0.0 0.0 0.0 0.0 1.9 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.4 1.1 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.2 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.1 0.2 0.1 0.0 0.1 0.1 0.2 0.1 KLK14 KLK-L6 ENSG00000129437 "Kallikrein related peptidase 14" Q9P0G3 19 51077495-51084245 "Cancer-related genes, Enzymes, Plasma proteins, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "skin 1: 14.2" "Cell line enhanced" "Detected in some" "HaCaT: 13.7;HEK 293: 3.9;U-266/84: 7.1" "Cancer enhanced" "Detected in many" "head and neck cancer: 26.8" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in all" CAB026228 Uncertain "Secreted in other tissues" "CAB026228: " "unprognostic (2.08e-1)" "unprognostic (1.22e-1)" "unprognostic (2.44e-2)" "unprognostic (2.60e-2)" "unprognostic (1.23e-1)" "unprognostic (6.12e-2)" "unprognostic (4.91e-2)" "unprognostic (5.79e-2)" "unprognostic (7.84e-2)" "unprognostic (1.38e-1)" "unprognostic (7.60e-2)" "unprognostic (8.87e-2)" "unprognostic (2.04e-8)" "unprognostic (1.93e-1)" "unprognostic (3.74e-3)" "unprognostic (1.94e-2)" "unprognostic (8.08e-2)" 0.2 0.0 0.4 0.2 1.2 0.1 2.7 2.1 0.9 3.8 0.6 1.8 0.4 0.9 1.2 0.8 0.3 1.1 0.6 0.5 0.1 0.1 0.5 0.4 0.3 0.9 0.4 0.0 0.3 0.0 0.7 0.4 1.1 0.7 0.3 14.2 1.0 0.0 0.3 0.4 0.8 0.7 0.1 0.6 0.2 3.9 0.0 0.0 0.3 0.1 0.0 0.0 0.0 1.7 0.7 0.1 0.9 0.6 0.6 0.7 0.2 0.0 0.0 0.2 1.7 2.1 0.8 0.6 0.3 13.7 0.2 0.3 0.0 0.5 3.9 0.3 1.0 0.0 0.2 0.3 0.3 0.4 0.4 0.5 0.6 0.2 0.3 0.5 0.0 1.2 0.2 0.8 0.8 1.5 0.2 0.1 0.8 0.0 0.7 0.1 0.0 0.3 1.2 0.4 0.6 0.0 0.0 0.2 0.6 0.9 0.2 3.6 7.1 0.5 0.1 0.3 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 KLK15 "ACO, HSRNASPH, prostinogen" ENSG00000174562 "Kallikrein related peptidase 15" Q9H2R5 19 50825289-50837213 "Cancer-related genes, Enzymes, Predicted intracellular proteins, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "intestine: 5.7;salivary gland: 9.7" "Cell line enriched" "Detected in some" 5 "RPMI-8226: 7.2" "Cancer enhanced" "Detected in some" "prostate cancer: 3.5" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA019802 Uncertain "Secreted to blood" "HPA019802: AB_1852601" "unprognostic (6.06e-2)" "unprognostic (2.85e-1)" "unprognostic (8.13e-2)" "unprognostic (2.90e-1)" "unprognostic (2.29e-2)" "unprognostic (1.16e-1)" "unprognostic (1.17e-1)" "unprognostic (1.55e-1)" "unprognostic (2.52e-1)" "unprognostic (2.72e-2)" 0.0 2.4 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 5.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 1.4 2.1 9.7 0.0 0.0 0.3 0.2 0.0 0.0 0.0 0.0 2.1 1.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 7.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 KLK2 ENSG00000167751 "Kallikrein related peptidase 2" P20151 19 50861568-50880567 "Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 29 "prostate: 163.5" "Cell line enhanced" "Detected in many" "NB-4: 9.9" "Cancer enriched" "Detected in some" 1666 "prostate cancer: 989.9" "Not detected" "Not detected" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in all" HPA000764 Supported "Secreted in male reproductive system" "HPA000764: AB_1079700" "unprognostic (3.05e-2)" "unprognostic (2.40e-1)" "unprognostic (1.69e-1)" "unprognostic (8.53e-2)" "unprognostic (1.15e-1)" "unprognostic (8.97e-2)" "unprognostic (3.22e-1)" "unprognostic (6.44e-2)" "unprognostic (8.06e-2)" "unprognostic (3.61e-1)" "unprognostic (2.11e-3)" "unprognostic (7.56e-2)" "unprognostic (8.10e-2)" "unprognostic (1.68e-1)" "unprognostic (2.04e-1)" 0.0 0.1 0.0 0.1 0.0 1.1 0.2 0.0 0.6 0.0 0.0 0.0 0.6 0.1 0.1 0.5 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 163.5 0.0 0.1 2.3 0.0 0.2 0.0 0.1 0.2 0.0 0.0 0.0 0.6 0.0 0.0 1.1 0.0 0.0 0.2 0.0 2.2 1.9 5.7 2.2 1.6 1.3 0.5 1.7 1.1 0.6 1.6 0.0 0.8 4.9 0.5 0.3 0.2 0.2 0.6 0.7 1.8 0.2 0.0 2.0 0.2 0.0 0.3 1.7 1.1 0.0 1.3 0.4 0.0 0.3 3.1 0.4 0.3 0.3 0.4 0.0 1.4 1.9 0.3 1.8 1.2 9.9 1.1 0.0 0.9 0.0 2.8 0.0 1.6 0.9 1.5 0.3 1.3 1.3 1.2 0.4 0.8 1.3 1.9 4.8 1.6 1.8 3.2 0.8 1.9 1.7 1.4 0.9 2.2 1.6 1.2 1.0 1.0 1.0 0.8 1.0 0.5 2.2 0.8 1.3 5.7 1.6 0.8 1.9 0.4 0.5 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 KLK3 "APS, PSA" ENSG00000142515 "Kallikrein related peptidase 3" P07288 19 50854915-50860764 "Cancer-related genes, Enzymes, Plasma proteins, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 115 "prostate: 447.4" "Group enriched" "Detected in some" 135 "BEWO: 21.9;NB-4: 18.5;RPMI-8226: 12.2;SH-SY5Y: 7.3;U-2197: 7.5" "Cancer enriched" "Detected in some" 3905 "prostate cancer: 4241.6" "Region enriched" "Detected in single" 8 "cerebral cortex: 1.0" "Not detected" "Not detected" "Not detected" "Not detected" "CAB000070, HPA000764" Enhanced "Secreted in male reproductive system" "CAB000070: , HPA000764: AB_1079700" "unprognostic (5.06e-3)" "unprognostic (5.60e-2)" "unprognostic (9.93e-2)" "unprognostic (3.90e-2)" "unprognostic (1.09e-2)" "unprognostic (1.26e-2)" "unprognostic (1.88e-2)" "unprognostic (1.54e-1)" "unprognostic (5.13e-3)" "unprognostic (1.94e-1)" "unprognostic (4.64e-1)" "unprognostic (3.15e-1)" 0.1 0.3 0.0 0.1 0.0 0.0 0.7 0.0 1.0 0.1 0.1 0.0 0.2 0.1 0.1 0.5 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 447.4 0.0 0.1 3.8 1.3 0.0 0.0 0.1 0.3 0.0 0.0 0.0 1.0 0.0 0.1 0.0 0.0 0.1 0.3 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 21.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 18.5 0.0 0.0 0.0 0.0 12.2 0.0 0.0 0.0 7.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 7.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.1 0.0 KLK4 "EMSP, EMSP1, KLK-L1, PRSS17, PSTS" ENSG00000167749 "Kallikrein related peptidase 4" Q9Y5K2 19 50906352-50910738 "Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins" Biomineralization "Hydrolase, Protease, Serine protease" "Amelogenesis imperfecta, Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 9 "prostate: 79.3" "Cell line enhanced" "Detected in many" "CAPAN-2: 8.2;HaCaT: 10.1;SK-BR-3: 6.5" "Cancer enriched" "Detected in many" 55 "prostate cancer: 463.7" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in many" HPA051839 Enhanced "Secreted in male reproductive system" "HPA051839: " "unprognostic (3.58e-2)" "unprognostic (2.26e-1)" "unprognostic (1.23e-3)" "unprognostic (1.66e-3)" "unprognostic (3.11e-2)" "unprognostic (4.35e-1)" "unprognostic (3.18e-1)" "unprognostic (6.66e-2)" "unprognostic (9.69e-2)" "unprognostic (8.23e-3)" "unprognostic (1.26e-1)" "unprognostic (1.07e-1)" "unprognostic (4.20e-3)" "unprognostic (3.27e-3)" "unprognostic (2.21e-2)" "unprognostic (1.64e-2)" "unprognostic (1.34e-1)" 0.2 0.8 0.1 0.3 0.1 0.1 0.7 0.2 0.5 2.0 1.2 0.0 3.8 1.8 1.5 7.7 0.4 0.2 0.1 0.1 0.3 0.2 0.2 0.1 0.2 0.0 0.2 0.0 0.1 0.1 0.0 0.1 0.1 0.5 79.3 0.8 0.2 3.2 2.1 0.7 2.4 1.2 0.6 0.1 0.1 0.3 0.6 0.1 0.0 8.7 0.0 0.0 0.2 0.2 0.1 0.4 0.6 0.1 0.0 0.3 0.0 5.0 2.1 0.2 0.3 0.0 0.0 4.5 0.1 0.0 0.0 0.0 4.6 8.2 0.5 0.4 0.1 10.1 0.0 5.4 0.0 1.3 1.4 1.6 3.7 1.7 0.0 1.7 2.3 0.0 2.6 0.0 0.0 0.0 0.9 4.2 0.0 1.2 0.1 2.5 0.1 0.4 0.3 0.5 1.1 0.0 3.3 0.0 0.6 0.3 6.5 0.0 5.2 0.4 1.1 0.3 0.3 1.3 0.3 2.6 1.0 0.5 0.1 0.3 0.0 0.0 0.0 0.0 0.3 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.4 0.0 0.0 0.1 0.1 0.2 0.5 0.3 0.2 0.2 0.0 0.5 0.1 KLK5 "KLK-L2, SCTE" ENSG00000167754 "Kallikrein related peptidase 5" Q9Y337 19 50943303-50953093 "Cancer-related genes, Enzymes, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 6 "skin 1: 69.2;tongue: 67.3" "Group enriched" "Detected in some" 40 "A-431: 85.3;HaCaT: 83.0" "Cancer enhanced" "Detected in many" "ovarian cancer: 112.2" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in all" "HPA014343, CAB025503, CAB026341" Enhanced "Secreted in other tissues" "CAB025503: , CAB026341: , HPA014343: AB_1852603" "unprognostic (3.19e-2)" "unprognostic (1.06e-1)" "prognostic unfavourable (2.33e-4)" "unprognostic (4.30e-4)" "unprognostic (3.01e-1)" "prognostic unfavourable (9.79e-4)" "unprognostic (3.04e-1)" "unprognostic (3.05e-1)" "unprognostic (1.70e-3)" "unprognostic (2.21e-1)" "unprognostic (2.76e-1)" "unprognostic (2.53e-1)" "unprognostic (9.16e-3)" "prognostic unfavourable (3.85e-6)" 1.1 0.0 0.7 0.4 0.2 0.0 12.1 0.2 0.5 3.8 0.3 0.2 0.2 0.1 1.4 0.9 6.5 0.2 0.3 0.2 0.2 0.1 0.6 0.2 2.5 0.2 0.2 0.2 0.2 0.2 0.0 0.2 0.2 0.4 0.2 0.0 0.3 7.0 0.2 0.4 69.2 0.2 0.2 0.2 0.2 0.0 3.3 0.2 0.4 0.3 67.3 4.4 0.2 3.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 85.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.1 0.0 0.0 0.0 83.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.2 0.0 0.0 0.2 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.2 0.2 0.5 0.2 0.1 0.2 0.2 0.4 0.2 KLK6 "Bssp, Klk7, neurosin, PRSS18, PRSS9" ENSG00000167755 "Kallikrein related peptidase 6" Q92876 19 50958631-50969673 "Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 97.6;esophagus: 48.9" "Group enriched" "Detected in some" 14 "A-431: 68.4;CAPAN-2: 163.7" "Cancer enhanced" "Detected in many" "ovarian cancer: 131.3" "Low region specificity" "Detected in all" "Not detected" "Not detected" "Not detected" "Not detected" "Region enhanced" "Detected in many" "pons and medulla: 175.6" "Group enriched" "Detected in many" 8 "midbrain: 106.3;pons and medulla: 164.1;thalamus: 62.4" HPA051837 Supported "Nucleoplasm,Nuclear membrane,Cytokinetic bridge" "Secreted in other tissues" 6800000 Nucleoplasm "Nuclear membrane, Cytokinetic bridge" "HPA051837: " "unprognostic (7.30e-2)" "unprognostic (3.32e-1)" "unprognostic (6.58e-2)" "prognostic unfavourable (1.38e-5)" "unprognostic (1.10e-1)" "unprognostic (2.31e-1)" "prognostic unfavourable (8.85e-4)" "unprognostic (3.02e-1)" "unprognostic (2.46e-1)" "prognostic unfavourable (7.82e-4)" "unprognostic (4.45e-1)" "unprognostic (2.72e-2)" "unprognostic (1.31e-1)" "unprognostic (2.46e-1)" "unprognostic (9.07e-2)" "prognostic unfavourable (1.27e-4)" 0.9 0.9 9.7 0.9 23.5 0.9 6.5 3.3 42.2 10.0 1.0 82.0 0.0 1.1 2.0 1.2 48.9 24.6 3.8 0.9 20.1 11.8 9.0 0.9 0.9 0.9 46.1 14.9 0.9 0.9 0.9 0.2 0.9 44.3 1.0 0.9 0.0 5.9 2.8 0.9 2.9 0.9 1.0 97.6 5.1 1.0 1.5 32.6 0.0 0.9 15.7 28.1 0.9 5.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 68.4 0.0 0.0 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.0 8.1 163.7 0.0 1.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.1 0.2 0.0 0.0 0.0 1.9 0.0 0.0 0.0 0.0 0.0 0.6 0.1 0.2 0.0 0.1 5.9 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 9.7 23.5 3.3 23.1 20.1 11.8 46.1 14.9 44.3 32.6 KLK7 "PRSS6, SCCE" ENSG00000169035 "Kallikrein related peptidase 7" P49862 19 50976482-50984099 "Cancer-related genes, Enzymes, Predicted intracellular proteins, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 4 "esophagus: 29.1;skin 1: 77.5;tongue: 90.2" "Group enriched" "Detected in some" 6 "CAPAN-2: 6.6;HaCaT: 25.9" "Cancer enhanced" "Detected in many" "ovarian cancer: 139.8" "Low region specificity" "Detected in many" "Low cell type specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Not detected" "Not detected" "Not detected" "Not detected" "HPA018994, CAB026342, HPA062126" Enhanced Supported "Nuclear membrane,Plasma membrane" "Secreted in other tissues" 960000 "Plasma membrane" "Nuclear membrane" "CAB026342: , HPA018994: AB_1852607, HPA062126: AB_2684691" "unprognostic (1.88e-2)" "unprognostic (6.41e-2)" "unprognostic (8.57e-2)" "prognostic unfavourable (8.06e-5)" "unprognostic (4.33e-3)" "unprognostic (2.28e-1)" "unprognostic (4.44e-3)" "unprognostic (2.99e-1)" "unprognostic (1.31e-1)" "prognostic unfavourable (1.16e-4)" "unprognostic (2.10e-1)" "unprognostic (2.82e-3)" "unprognostic (3.25e-1)" "unprognostic (4.47e-2)" "unprognostic (1.12e-2)" "unprognostic (5.60e-3)" 2.1 0.3 5.4 0.3 4.3 0.4 5.6 0.5 11.3 5.4 0.3 0.0 0.0 0.5 0.7 0.3 29.1 7.8 3.3 0.2 4.8 0.5 2.6 0.2 1.6 0.3 0.3 3.5 1.0 0.2 0.2 0.1 0.5 4.2 0.3 0.2 0.0 7.4 0.3 0.6 77.5 0.3 0.4 0.3 0.5 0.4 0.3 0.0 0.0 0.4 90.2 15.3 0.2 9.0 1.1 0.4 1.3 0.8 2.1 1.0 0.6 2.6 0.0 0.0 0.2 0.0 0.0 1.3 0.0 0.0 0.0 0.0 1.5 6.6 0.0 1.0 0.0 25.9 0.0 0.8 0.0 0.0 0.3 0.1 0.0 0.0 0.0 0.0 0.2 0.0 2.1 0.0 0.0 0.0 0.0 0.3 0.0 0.1 0.1 0.1 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.1 0.1 1.3 0.8 0.4 0.4 0.4 0.7 0.6 0.6 0.4 0.4 1.1 1.0 0.9 0.9 2.1 0.4 0.4 0.7 0.6 5.4 4.3 0.5 11.3 4.8 0.5 0.3 3.5 4.2 0.0 KLK8 "HNP, neuropsin, ovasin, PRSS19, TADG14" ENSG00000129455 "Kallikrein related peptidase 8" O60259 19 50996007-51002711 "Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "esophagus: 43.6;skin 1: 40.4;tongue: 46.9" "Group enriched" "Detected in some" 7 "A-431: 31.5;CAPAN-2: 41.3;HaCaT: 30.5" "Cancer enhanced" "Detected in many" "head and neck cancer: 29.9;ovarian cancer: 30.7" "Low region specificity" "Detected in single" "Not detected" "Not detected" "Not detected" "Not detected" "Region enriched" "Detected in many" 5 "hippocampal formation: 39.6" "CAB019393, HPA035761" Enhanced Approved Vesicles "Secreted in other tissues" 950000 Vesicles "CAB019393: , HPA035761: " "unprognostic (4.27e-3)" "unprognostic (2.59e-1)" "unprognostic (2.54e-1)" "prognostic unfavourable (2.31e-4)" "unprognostic (5.46e-2)" "prognostic unfavourable (5.72e-4)" "unprognostic (2.95e-1)" "unprognostic (9.02e-2)" "prognostic unfavourable (1.10e-4)" "unprognostic (4.29e-2)" "unprognostic (4.66e-2)" "unprognostic (1.54e-1)" "prognostic unfavourable (6.17e-4)" 1.6 0.0 0.1 0.4 0.1 0.0 4.5 1.0 0.3 8.1 0.7 0.1 0.1 0.0 1.1 0.7 43.6 6.7 0.3 0.1 0.1 0.0 0.2 0.1 0.1 0.1 0.1 0.1 1.1 0.1 0.0 0.1 0.4 0.6 0.3 0.0 0.3 6.0 0.1 0.3 40.4 0.1 0.1 0.6 0.3 0.0 0.7 0.1 0.5 0.3 46.9 11.1 0.3 13.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 31.5 0.0 0.0 0.2 0.0 0.0 4.6 0.0 0.0 0.0 0.0 0.6 41.3 0.0 0.8 0.0 30.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 1.0 0.3 0.1 0.0 0.1 0.1 0.6 0.1 KLK9 KLK-L3 ENSG00000213022 "Kallikrein related peptidase 9" Q9UKQ9 19 51003111-51009634 "Cancer-related genes, Enzymes, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 5 "tongue: 37.6" "Group enriched" "Detected in some" 27 "HaCaT: 1.2;HBEC3-KT: 4.1" "Cancer enriched" "Detected in single" 6 "head and neck cancer: 0.7" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" CAB025049 Enhanced "Secreted to digestive system" "CAB025049: " "unprognostic (3.22e-2)" 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 4.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 8.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 37.6 3.8 0.0 1.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 4.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 KLKB1 KLK3 ENSG00000164344 "Kallikrein B1" P03952 4 186208979-186258471 "Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Blood coagulation, Fibrinolysis, Hemostasis, Inflammatory response" "Hydrolase, Protease, Serine protease" "Disease mutation, FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 76 "liver: 102.9" "Cell line enhanced" "Detected in some" "NTERA-2: 7.1;SCLC-21H: 4.9;SK-MEL-30: 2.1;U-937: 2.4" "Cancer enriched" "Detected in some" 17 "liver cancer: 27.6" "Low region specificity" "Detected in single" "Cell type enriched" "Detected in single" 7 "gdT-cell: 1.3" "Lineage enriched" "Detected in single" 8 "T-cells: 1.3" "Not detected" "Not detected" "Low region specificity" "Detected in all" "Secreted to blood" 28860000000 4900000000 "unprognostic (4.80e-2)" "unprognostic (4.53e-3)" "unprognostic (4.36e-2)" "unprognostic (4.17e-2)" "unprognostic (5.93e-2)" "unprognostic (1.90e-2)" "unprognostic (1.15e-2)" "unprognostic (2.83e-1)" "unprognostic (8.14e-2)" "unprognostic (1.35e-1)" "unprognostic (1.38e-2)" "unprognostic (1.15e-1)" "unprognostic (1.45e-2)" "unprognostic (6.01e-2)" "unprognostic (7.30e-2)" "unprognostic (1.20e-1)" "unprognostic (1.59e-2)" 0.3 0.3 0.8 0.3 1.2 0.0 0.3 0.7 0.5 0.3 0.4 0.3 0.3 0.7 0.4 0.4 0.3 0.2 0.7 0.5 0.6 0.5 1.3 102.9 0.3 0.3 0.5 0.5 0.3 1.3 0.5 1.0 0.4 0.4 0.3 0.3 0.5 0.3 0.3 0.5 0.1 0.6 0.3 0.3 0.5 0.0 0.3 0.3 0.4 0.3 0.3 0.4 0.3 0.3 0.1 0.1 0.0 0.0 0.0 1.3 0.0 0.0 0.0 0.0 0.0 0.2 0.8 0.2 0.0 0.0 0.0 0.2 0.0 0.4 0.3 0.3 0.0 0.2 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.2 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.4 0.0 7.1 0.0 0.1 0.0 0.2 1.3 0.0 4.9 0.4 0.2 0.0 2.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.4 0.1 0.0 0.0 0.0 1.3 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.8 1.2 0.7 0.5 0.6 0.5 0.5 0.5 0.4 0.3 LACTB "FLJ14902, MRPL56" ENSG00000103642 "Lactamase beta" P83111 15 63121800-63142061 "Enzymes, Predicted intracellular proteins" "Lipid metabolism" "Hydrolase, Protease" "Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA036361, HPA036362" Supported Supported Mitochondria "Intracellular and membrane" Mitochondria "HPA036361: AB_10672244, HPA036362: AB_10670798" "unprognostic (6.07e-2)" "unprognostic (2.02e-1)" "unprognostic (2.22e-2)" "unprognostic (2.87e-1)" "unprognostic (1.20e-2)" "unprognostic (3.10e-2)" "unprognostic (8.08e-2)" "unprognostic (6.25e-2)" "unprognostic (8.98e-2)" "unprognostic (3.08e-1)" "unprognostic (6.22e-3)" "unprognostic (5.16e-3)" "unprognostic (6.28e-2)" "unprognostic (3.24e-1)" "unprognostic (8.64e-2)" "unprognostic (7.90e-2)" "unprognostic (3.88e-3)" 26.5 22.7 9.2 13.1 12.2 31.5 9.3 7.3 9.1 6.8 11.4 6.3 4.0 12.5 7.0 6.9 9.8 5.7 9.2 24.9 7.9 6.1 20.5 38.3 18.8 12.9 8.5 6.1 7.2 9.3 6.7 10.4 7.4 9.5 7.6 10.4 5.8 9.3 4.7 37.3 10.1 19.6 8.1 8.0 21.6 8.3 13.2 9.8 8.3 8.4 11.1 9.0 11.5 12.8 3.3 10.4 5.8 8.9 2.3 3.1 2.0 21.4 13.5 3.8 2.6 19.5 10.5 3.2 9.4 14.5 16.2 30.2 3.4 13.8 2.8 11.6 13.6 6.0 13.1 6.1 20.3 19.7 3.2 5.5 4.6 8.4 18.2 5.0 9.6 14.2 13.0 16.6 13.7 16.6 5.2 8.2 27.3 8.1 3.8 6.0 5.8 4.2 2.8 9.9 6.5 8.7 33.6 3.5 1.6 6.8 7.7 20.2 5.8 8.2 29.7 21.8 17.1 9.8 11.8 8.6 7.5 0.7 16.7 14.1 10.0 3.6 8.8 4.6 1.3 8.9 2.0 3.3 1.1 1.0 10.4 2.9 1.0 1.6 5.8 2.3 7.6 0.9 3.1 2.0 9.2 12.2 7.3 9.1 7.9 6.1 8.5 6.1 9.5 9.8 LAP3 "LAP, LAPEP, PEPS" ENSG00000002549 "Leucine aminopeptidase 3" P28838 4 17577192-17607972 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Aminopeptidase, Hydrolase, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA029606, HPA029607" Enhanced Supported Nucleoplasm,Midbody,Cytosol 4100000 Cytosol "Nucleoplasm, Midbody" "HPA029606: AB_10599288, HPA029607: AB_10611381" "unprognostic (2.10e-2)" "unprognostic (1.01e-1)" "unprognostic (6.95e-3)" "unprognostic (1.46e-1)" "unprognostic (1.26e-1)" "unprognostic (2.87e-1)" "unprognostic (2.16e-1)" "unprognostic (1.55e-1)" "unprognostic (5.33e-2)" "unprognostic (1.44e-3)" "unprognostic (2.61e-3)" "unprognostic (1.17e-1)" "unprognostic (4.29e-3)" "unprognostic (1.73e-1)" "unprognostic (3.28e-2)" "unprognostic (3.06e-1)" "unprognostic (8.79e-2)" 42.5 29.7 23.2 43.9 38.5 18.1 30.7 8.5 23.5 13.3 21.0 23.5 12.3 27.5 17.2 20.8 19.3 18.7 24.3 25.4 24.4 17.0 71.7 70.3 39.4 54.2 33.7 16.1 13.5 14.7 23.5 13.2 25.0 34.9 15.3 22.7 15.0 23.0 12.1 33.3 20.9 30.6 26.9 35.0 54.9 20.8 19.3 30.7 19.9 29.4 21.7 32.1 24.4 23.7 7.5 45.7 9.5 46.1 11.8 12.9 25.3 10.8 9.5 9.1 8.6 18.1 22.1 0.1 17.1 19.3 62.3 75.7 17.3 20.7 42.7 11.4 13.1 6.7 34.2 12.1 23.7 16.3 9.8 23.7 10.5 22.6 21.1 21.3 15.2 22.4 7.7 20.4 10.7 21.6 22.9 30.5 14.6 11.7 18.9 29.2 19.0 18.2 29.4 8.7 21.6 16.2 12.7 13.5 11.1 15.7 9.7 33.5 8.2 8.2 14.0 15.8 10.7 16.6 29.7 28.1 42.9 36.9 21.4 35.5 15.3 8.4 43.4 9.5 8.0 46.1 7.4 7.5 7.5 8.5 45.7 5.2 6.5 6.8 6.2 11.8 31.9 25.9 12.9 25.3 23.2 38.5 8.5 23.5 24.4 17.0 33.7 16.1 34.9 30.7 LGMN "LGMN1, PRSC1" ENSG00000100600 Legumain Q99538 14 92703807-92748702 "Cancer-related genes, Enzymes, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in many" 4 "RPMI-8226: 127.6;U-266/70: 70.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Cell type enriched" "Detected in many" 11 "plasmacytoid DC: 54.2" "Lineage enriched" "Detected in many" 11 "dendritic cells: 54.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA001426 Enhanced Approved Nucleoplasm,Vesicles "Intracellular and membrane" 1200000 Vesicles Nucleoplasm "HPA001426: AB_1079247" "unprognostic (1.19e-1)" "unprognostic (1.16e-1)" "unprognostic (2.37e-1)" "unprognostic (1.52e-1)" "unprognostic (1.99e-1)" "unprognostic (3.29e-2)" "unprognostic (4.52e-2)" "unprognostic (1.31e-1)" "unprognostic (5.03e-2)" "unprognostic (3.50e-2)" "unprognostic (4.70e-2)" "unprognostic (2.47e-1)" "prognostic favourable (4.70e-4)" "unprognostic (8.06e-2)" "unprognostic (3.64e-2)" "unprognostic (7.18e-3)" "unprognostic (7.24e-2)" 42.9 16.3 8.6 17.4 10.7 3.5 19.9 5.8 17.9 13.3 22.3 11.7 13.9 24.2 12.1 48.1 17.4 14.1 32.7 38.8 10.3 10.1 87.6 44.6 31.5 42.4 8.3 10.1 20.5 14.6 54.4 9.7 113.6 9.9 22.0 24.5 23.2 22.6 8.4 17.3 11.9 37.1 23.3 11.5 58.3 23.7 14.0 7.9 17.2 36.8 19.2 17.3 31.4 18.2 4.7 54.2 0.7 0.8 1.0 4.3 1.7 4.8 7.0 4.7 8.6 14.6 11.8 16.4 10.5 10.0 10.9 12.9 5.4 8.7 2.7 15.5 17.1 12.1 0.0 9.0 5.2 0.2 5.4 0.1 3.9 6.2 4.3 0.1 0.4 8.3 4.4 10.5 6.0 12.9 1.0 22.6 0.7 6.5 1.2 0.2 2.3 4.8 1.2 4.1 127.6 11.8 19.0 5.1 3.5 14.5 8.9 7.5 6.6 0.0 7.0 5.4 6.9 9.7 3.1 70.2 8.2 3.6 3.0 0.1 10.3 0.7 0.4 0.1 0.2 0.8 0.4 4.7 1.4 0.4 5.0 3.4 4.3 2.5 0.5 1.0 0.2 54.2 2.6 1.7 8.6 10.7 5.8 17.9 10.3 10.1 8.3 10.1 9.9 7.9 LMLN "Gp63, LMNL1, Msp" ENSG00000185621 "Leishmanolysin like peptidase" Q96KR4 3 197960200-198043720 "Enzymes, Predicted intracellular proteins, Predicted membrane proteins" "Cell cycle, Cell division, Mitosis" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA016481, HPA028844" Uncertain Supported "Focal adhesion sites,Cytosol" Cytosol "Focal adhesion sites" "HPA016481: AB_1852955, HPA028844: AB_10602347" "unprognostic (2.54e-1)" "unprognostic (3.15e-1)" "unprognostic (7.63e-2)" "prognostic favourable (6.77e-4)" "unprognostic (1.14e-2)" "unprognostic (1.19e-1)" "unprognostic (1.30e-1)" "unprognostic (4.07e-2)" "unprognostic (1.94e-1)" "unprognostic (2.31e-1)" "unprognostic (6.36e-2)" "unprognostic (2.98e-1)" "unprognostic (4.82e-3)" "unprognostic (8.78e-2)" "unprognostic (7.65e-2)" "unprognostic (1.01e-1)" "unprognostic (1.63e-1)" 3.9 4.9 5.2 2.5 11.0 2.3 4.5 6.1 9.1 6.2 3.5 5.8 14.3 2.2 4.8 20.3 3.5 9.3 5.1 5.9 5.7 7.4 6.6 3.7 8.1 3.5 5.6 8.9 6.5 6.1 8.8 15.0 3.9 11.6 4.6 4.1 5.4 4.2 11.7 3.7 6.5 2.3 4.0 5.5 3.0 3.9 27.0 4.4 1.2 7.6 3.0 2.6 3.5 3.7 1.9 1.9 0.8 2.4 1.8 2.4 1.2 6.5 2.5 3.0 3.5 5.9 8.3 2.5 3.4 3.1 6.2 5.1 2.4 2.4 2.1 16.0 2.4 2.5 2.8 2.7 9.0 0.3 2.0 1.2 2.1 1.8 3.7 3.7 1.8 3.9 6.1 7.7 5.0 2.7 6.3 4.0 5.9 4.9 2.2 3.2 3.3 6.0 2.5 0.7 2.2 6.4 1.7 4.8 1.4 4.8 4.3 3.4 11.1 2.8 5.7 7.6 1.1 9.2 5.7 7.1 13.8 0.6 10.9 6.4 6.9 0.2 0.6 0.5 1.2 2.4 1.7 1.9 0.8 1.6 1.9 1.1 2.2 2.4 0.8 1.8 0.9 0.5 0.0 1.2 5.2 11.0 6.1 9.1 5.7 7.4 5.6 8.9 11.6 4.4 LNPEP "CAP, IRAP, P-LAP, PLAP" ENSG00000113441 "Leucyl and cystinyl aminopeptidase" Q9UIQ6 5 96935394-97037515 "Enzymes, Predicted membrane proteins" "Aminopeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in all" 4 "placenta: 104.4" "Low cell line specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA043642 Approved "Intracellular and membrane" 390000 "HPA043642: AB_10964137" "unprognostic (1.52e-1)" "unprognostic (5.39e-2)" "unprognostic (7.78e-2)" "unprognostic (1.53e-2)" "unprognostic (6.38e-2)" "unprognostic (6.59e-3)" "unprognostic (6.83e-2)" "unprognostic (2.11e-1)" "unprognostic (1.11e-1)" "unprognostic (3.54e-3)" "unprognostic (6.24e-2)" "unprognostic (2.08e-1)" "unprognostic (3.28e-1)" "unprognostic (4.13e-3)" "unprognostic (1.46e-1)" "unprognostic (1.69e-1)" "unprognostic (1.17e-1)" 9.8 4.7 5.6 12.0 7.3 13.2 7.7 23.3 12.9 6.3 7.6 6.9 7.8 4.2 8.2 4.4 10.2 6.6 4.3 10.1 5.2 5.6 7.6 4.3 6.9 15.9 7.7 8.8 8.2 5.9 13.8 9.7 104.4 9.1 7.9 6.8 3.9 7.8 7.7 13.2 14.0 9.0 6.6 7.5 10.0 8.5 3.3 7.7 23.6 7.2 2.9 15.8 8.9 7.7 4.1 3.5 5.0 12.8 11.2 7.9 4.3 5.3 6.2 2.8 3.0 17.1 8.2 3.3 5.5 7.3 6.5 9.9 5.2 8.7 26.5 10.4 7.4 7.1 3.6 10.4 6.8 9.4 2.0 6.6 4.5 3.6 4.4 7.6 9.2 6.3 6.5 9.4 6.9 6.8 2.8 17.6 7.4 4.8 9.0 5.3 0.6 3.3 6.6 10.6 4.0 23.2 11.1 5.5 1.4 6.7 5.9 3.3 18.1 10.1 13.5 9.5 5.3 7.5 8.3 3.8 8.8 24.2 8.4 7.3 4.3 5.0 3.3 4.4 7.9 5.5 6.8 3.1 5.9 6.1 3.5 4.1 5.9 6.4 4.1 11.2 12.8 3.3 5.1 4.3 5.6 7.3 23.3 12.9 5.2 5.6 7.7 8.8 9.1 7.7 LONP1 "hLON, LonHS, PIM1, PRSS15" ENSG00000196365 "Lon peptidase 1, mitochondrial" P36776 19 5691834-5720572 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" "DNA-binding, Hydrolase, Protease, Serine protease" "Cataract, Deafness, Disease mutation, Dwarfism" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "adrenal gland: 78.3" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA002034, HPA002192" Supported Enhanced Nucleoplasm,Mitochondria Mitochondria Nucleoplasm "HPA002034: AB_2756304, HPA002192: AB_1079695" "unprognostic (6.52e-2)" "unprognostic (1.12e-1)" "unprognostic (2.43e-1)" "unprognostic (2.43e-2)" "unprognostic (2.84e-1)" "unprognostic (2.38e-1)" "unprognostic (1.66e-3)" "unprognostic (5.56e-2)" "unprognostic (2.71e-1)" "unprognostic (7.57e-2)" "unprognostic (4.04e-2)" "unprognostic (1.26e-1)" "unprognostic (1.76e-2)" "unprognostic (1.09e-2)" "unprognostic (1.24e-1)" "unprognostic (1.11e-1)" "unprognostic (2.11e-1)" 15.8 78.3 16.4 12.8 19.8 12.5 13.9 16.1 22.8 11.3 13.6 15.8 13.3 13.7 10.5 13.8 12.7 12.7 15.7 27.3 15.4 15.3 19.9 49.6 10.3 14.5 17.7 14.9 15.5 17.7 17.6 16.8 16.6 16.2 11.7 8.5 12.7 18.5 14.7 38.0 14.7 13.9 11.5 12.7 15.5 13.5 9.8 13.3 13.8 21.2 15.3 11.8 14.7 12.5 6.7 6.5 6.0 6.2 4.0 7.2 3.0 23.0 23.9 7.9 25.3 9.4 6.7 24.7 14.7 11.7 15.9 19.5 20.4 8.3 29.0 20.6 15.4 9.8 20.4 17.8 7.7 17.1 16.8 16.0 20.9 26.7 43.7 36.4 16.8 12.6 25.6 15.1 29.9 12.7 42.3 57.8 7.3 15.3 18.0 21.7 28.3 31.6 19.0 11.4 31.2 8.8 13.7 21.1 21.1 12.9 18.9 51.6 11.1 45.7 9.0 8.1 8.9 22.5 21.4 60.9 37.5 25.7 36.5 39.9 14.6 6.0 4.1 0.8 6.4 6.2 4.1 6.0 5.6 6.1 4.3 6.7 7.2 4.8 0.5 4.0 2.4 6.5 4.0 3.0 16.4 19.8 16.1 22.8 15.4 15.3 17.7 14.9 16.2 13.3 LONP2 "LONP, LONPL, MGC4840" ENSG00000102910 "Lon peptidase 2, peroxisomal" Q86WA8 16 48244296-48363122 "Enzymes, Predicted intracellular proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA008862 Uncertain "HPA008862: AB_2137156" "unprognostic (8.08e-3)" "prognostic unfavourable (4.55e-4)" "unprognostic (1.75e-2)" "unprognostic (2.33e-2)" "unprognostic (6.08e-2)" "unprognostic (1.60e-2)" "unprognostic (7.59e-3)" "unprognostic (2.13e-1)" "unprognostic (2.36e-1)" "unprognostic (3.10e-2)" "unprognostic (5.39e-2)" "unprognostic (1.40e-1)" "prognostic favourable (6.71e-7)" "unprognostic (6.53e-2)" "unprognostic (1.49e-1)" "unprognostic (5.60e-2)" "unprognostic (1.33e-1)" 15.8 17.0 16.0 13.9 22.2 9.4 36.1 18.9 20.7 16.1 17.4 16.3 15.3 15.2 15.8 20.6 14.5 17.6 19.0 16.7 15.0 15.0 15.9 69.2 11.3 12.8 15.2 15.8 22.1 20.7 40.0 23.3 11.1 17.2 23.1 14.8 30.9 15.0 18.1 18.0 13.5 14.8 16.3 14.1 12.5 14.9 7.0 13.7 14.9 24.9 11.6 13.2 16.7 13.7 13.3 13.1 8.7 13.7 9.0 15.9 11.0 13.7 19.3 9.7 14.9 25.7 21.2 18.4 17.8 13.6 16.7 7.7 10.0 7.1 6.3 17.6 17.8 17.3 19.7 19.6 23.4 10.2 12.4 9.2 12.3 21.8 15.8 15.4 12.4 19.7 21.9 15.6 14.7 12.4 15.5 6.8 17.2 12.4 14.9 7.7 8.1 19.2 19.4 19.8 19.9 18.9 9.3 17.0 10.1 20.1 22.6 17.9 9.5 11.8 16.5 17.3 10.3 15.0 13.6 13.8 12.5 10.4 20.2 10.4 12.5 6.8 13.7 8.7 13.3 13.6 14.0 12.8 15.9 13.5 13.1 13.3 15.0 13.8 5.3 9.0 13.6 9.6 11.8 11.0 16.0 22.2 18.9 20.7 15.0 15.0 15.2 15.8 17.2 13.7 LPA "LP, Lp(a)" ENSG00000198670 Lipoprotein(a) P08519 6 160531483-160664259 "Candidate cardiovascular disease genes, Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Lipid transport, Transport" "Hydrolase, Protease, Serine protease" Atherosclerosis "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 71 "liver: 43.4" "Cell line enriched" "Detected in single" 6 "RT4: 4.6" "Cancer enriched" "Detected in single" 38 "liver cancer: 3.6" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "CAB016072, HPA060604" Supported "Secreted to blood" 78800000000 2900000000 "CAB016072: AB_2135240, HPA060604: " "unprognostic (2.16e-1)" "unprognostic (5.10e-1)" "unprognostic (7.75e-3)" "unprognostic (6.70e-2)" "unprognostic (1.60e-1)" "unprognostic (4.17e-3)" "unprognostic (1.59e-1)" "unprognostic (6.38e-3)" "unprognostic (3.63e-2)" "unprognostic (3.18e-1)" "unprognostic (7.45e-3)" "unprognostic (2.56e-1)" "unprognostic (1.80e-1)" "unprognostic (1.34e-1)" "unprognostic (3.72e-2)" 0.1 0.0 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.3 0.1 0.1 0.1 0.2 0.2 43.4 0.1 0.1 0.1 0.1 0.1 0.2 0.0 0.1 0.1 0.1 0.2 0.0 0.1 0.1 0.6 0.1 0.0 0.1 0.1 0.1 0.1 0.0 0.2 0.1 0.1 0.1 0.1 0.1 0.3 0.1 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.4 0.0 0.0 0.5 0.0 0.0 0.1 0.0 0.0 4.6 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.1 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.1 0.1 0.1 0.1 0.2 0.1 0.1 0.1 0.1 LTA4H ENSG00000111144 "Leukotriene A4 hydrolase" P09960 12 96000828-96043520 "Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins" "Leukotriene biosynthesis" "Hydrolase, Metalloprotease, Protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA008399, CAB015221, HPA017017" Supported Approved Nucleoplasm,Cytosol 85000000 "Nucleoplasm, Cytosol" "CAB015221: , HPA008399: AB_1852816, HPA017017: AB_1852818" "prognostic favourable (9.79e-4)" "unprognostic (6.62e-2)" "unprognostic (6.04e-2)" "unprognostic (1.87e-1)" "unprognostic (1.38e-2)" "unprognostic (2.59e-2)" "unprognostic (4.25e-3)" "prognostic favourable (8.96e-4)" "unprognostic (1.72e-1)" "unprognostic (1.75e-2)" "unprognostic (3.38e-2)" "unprognostic (1.34e-1)" "unprognostic (1.73e-1)" "unprognostic (1.74e-1)" "unprognostic (1.04e-1)" "unprognostic (3.50e-2)" "unprognostic (1.34e-1)" 27.9 33.2 11.2 21.5 16.7 55.7 19.0 24.1 15.6 27.2 29.1 13.1 16.7 27.6 27.6 14.1 53.4 22.7 14.5 19.2 10.6 12.2 27.2 19.4 68.0 33.4 12.3 11.3 49.9 28.2 21.2 31.8 11.3 13.3 29.6 17.8 20.7 21.1 16.1 20.6 23.6 41.2 21.5 13.3 44.3 22.1 13.7 11.5 29.2 38.8 22.3 43.1 30.1 25.2 20.6 35.3 6.1 84.2 14.2 9.0 54.6 23.5 25.4 35.7 21.3 31.0 34.7 15.6 9.9 29.3 19.6 22.8 18.6 20.5 52.9 12.4 14.7 31.1 29.2 40.3 26.8 18.1 28.3 19.4 16.3 22.5 18.3 10.2 11.8 33.0 34.0 27.0 33.1 38.7 11.8 9.3 28.2 16.2 26.8 31.5 41.6 34.5 25.2 26.6 30.5 35.9 30.1 18.5 21.9 20.0 23.4 21.4 29.0 12.5 13.8 8.3 14.0 11.8 10.7 12.6 21.8 24.5 5.9 18.6 6.5 0.4 76.0 2.2 4.5 84.2 8.4 15.1 6.3 5.8 35.3 20.6 9.0 6.7 6.1 14.2 73.2 8.7 6.3 54.6 11.2 16.7 24.1 15.6 10.6 12.2 12.3 11.3 13.3 11.5 LVRN "APQ, AQPEP, FLJ90650, TAQPEP" ENSG00000172901 Laeverin Q6Q4G3 5 115962454-116027619 "Enzymes, Predicted intracellular proteins" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 7 "placenta: 75.1" "Cell line enhanced" "Detected in some" "ASC diff: 2.3;ASC TERT1: 3.8;CAPAN-2: 1.8;SiHa: 1.5;U-266/70: 1.5" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA053254 Enhanced "Intracellular and membrane" "HPA053254: " "unprognostic (1.47e-1)" "unprognostic (3.38e-3)" "unprognostic (5.81e-2)" "unprognostic (2.97e-3)" "unprognostic (5.38e-2)" "unprognostic (1.32e-1)" "unprognostic (2.59e-3)" "unprognostic (1.88e-2)" "unprognostic (2.23e-1)" "unprognostic (2.23e-2)" "unprognostic (3.83e-3)" "unprognostic (1.22e-1)" "unprognostic (1.67e-7)" "unprognostic (1.05e-2)" "unprognostic (5.94e-2)" "unprognostic (6.53e-2)" "unprognostic (3.31e-2)" 10.6 0.1 0.0 0.5 0.0 0.1 3.9 0.0 0.0 0.3 1.4 0.0 0.4 0.1 0.0 0.0 1.8 0.2 0.4 1.1 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.9 0.1 0.0 0.1 75.1 0.0 0.7 0.4 0.0 0.6 1.2 1.3 1.0 1.7 0.5 0.0 0.0 0.4 0.3 0.0 0.0 0.3 1.7 0.1 0.7 0.7 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.2 0.0 0.3 0.1 2.3 3.8 0.8 0.2 0.3 0.1 0.3 0.0 1.8 0.0 0.2 0.0 0.0 0.0 0.0 0.5 1.1 0.1 0.0 0.9 0.0 0.0 0.2 0.3 1.3 0.4 0.0 0.0 0.1 0.0 0.3 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.4 1.5 0.0 0.0 0.0 0.0 0.0 0.3 0.3 0.0 0.6 1.5 0.1 0.1 0.2 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 MALT1 "MLT, PCASP1" ENSG00000172175 "MALT1 paracaspase" Q9UDY8 18 58671386-58754477 "Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease" "Cancer-related genes, Disease mutation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell line enhanced" "Detected in all" "RPTEC TERT1: 50.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "CAB004494, HPA048432" Enhanced Approved "Nucleoli fibrillar center,Cytosol" "Nucleoli fibrillar center" Cytosol "CAB004494: AB_627909, HPA048432: " "unprognostic (3.25e-1)" "unprognostic (2.31e-1)" "unprognostic (3.64e-2)" "unprognostic (3.25e-2)" "unprognostic (1.65e-3)" "unprognostic (4.67e-2)" "unprognostic (6.46e-2)" "unprognostic (4.50e-2)" "unprognostic (3.33e-2)" "unprognostic (4.16e-3)" "unprognostic (3.74e-1)" "unprognostic (2.07e-1)" "unprognostic (2.53e-2)" "unprognostic (2.34e-1)" "unprognostic (2.97e-1)" "unprognostic (1.03e-1)" "unprognostic (6.00e-2)" 11.2 3.9 4.1 21.7 5.6 10.2 10.6 9.1 6.8 11.0 10.7 3.9 10.9 5.5 8.1 10.5 16.4 6.6 8.1 8.7 4.0 4.3 14.9 10.5 14.3 29.0 4.1 1.8 8.1 6.2 10.0 9.3 8.8 4.9 18.1 7.9 7.5 10.7 8.4 10.7 12.6 12.2 6.6 6.2 19.9 6.2 11.8 4.8 22.4 7.9 12.4 24.0 9.6 12.3 6.3 3.6 1.2 1.7 1.6 4.8 1.1 7.4 10.6 13.0 3.2 2.6 5.8 5.8 13.3 9.4 11.6 9.9 8.6 9.6 11.8 6.0 16.5 7.3 5.6 5.5 14.3 7.9 3.1 4.2 7.6 13.8 4.2 8.5 5.7 3.6 11.7 9.1 9.2 2.5 6.8 20.6 6.3 2.4 1.8 3.6 3.2 3.6 6.4 7.7 8.3 50.8 3.1 1.4 3.0 7.3 3.8 5.0 3.7 4.9 3.4 15.0 6.6 4.4 12.2 18.4 21.8 10.3 6.0 6.4 5.9 0.8 1.5 1.0 2.7 1.7 2.1 3.6 4.8 2.9 2.2 6.3 4.3 2.8 1.2 1.6 1.6 3.6 2.9 1.1 4.1 5.6 9.1 6.8 4.0 4.3 4.1 1.8 4.9 4.8 MASP1 "CRARF, MASP, PRSS5" ENSG00000127241 "Mannan binding lectin serine peptidase 1" P48740 3 187217285-187292022 "Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins" "Complement activation lectin pathway, Immunity, Innate immunity" "Hydrolase, Protease, Serine protease" "Disease mutation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "cervix, uterine: 43.4;liver: 80.1" "Group enriched" "Detected in some" 8 "BJ: 26.5;BJ hTERT+: 101.0" "Group enriched" "Detected in some" 9 "glioma: 6.8;liver cancer: 7.7;prostate cancer: 3.0;renal cancer: 3.9" "Low region specificity" "Detected in all" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA001617, HPA009641" Supported Enhanced Nucleoplasm,Cytosol "Secreted to blood" 8673000000 1800000000 "Nucleoplasm, Cytosol" "HPA001617: AB_1079314, HPA009641: AB_1079313" "unprognostic (1.67e-1)" "unprognostic (1.02e-2)" "unprognostic (1.99e-1)" "unprognostic (5.20e-2)" "unprognostic (1.02e-2)" "unprognostic (1.25e-6)" "prognostic favourable (2.20e-4)" "unprognostic (9.92e-2)" "unprognostic (3.22e-1)" "unprognostic (2.29e-1)" "unprognostic (4.18e-1)" "unprognostic (1.29e-1)" "unprognostic (2.82e-3)" "unprognostic (3.56e-3)" "unprognostic (1.97e-1)" "unprognostic (7.85e-2)" "unprognostic (4.29e-1)" 2.1 1.4 3.6 1.2 3.8 0.1 1.2 1.9 10.2 43.4 19.1 14.8 2.4 0.8 34.9 7.1 4.1 6.7 3.3 39.6 6.1 2.5 1.6 80.1 2.2 0.4 6.4 3.0 1.7 0.2 0.2 0.5 3.2 13.0 17.4 2.1 0.1 0.9 19.4 12.2 2.5 2.6 17.1 21.8 0.4 0.6 1.5 6.7 0.0 1.3 6.3 3.5 4.4 24.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.3 3.7 0.0 26.5 101.0 0.3 0.1 0.0 0.0 0.0 0.0 8.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.4 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.6 3.8 1.9 3.5 6.1 2.5 6.4 3.0 13.0 6.7 MASP2 MASP1P1 ENSG00000009724 "Mannan binding lectin serine peptidase 2" O00187 1 11026523-11047233 "Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted secreted proteins" "Complement pathway, Immunity, Innate immunity" "Hydrolase, Protease, Serine protease" "Disease mutation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 98 "liver: 185.1" "Cell line enriched" "Detected in many" 7 "Hep G2: 20.1" "Cancer enriched" "Detected in some" 71 "liver cancer: 41.9" "Region enriched" "Detected in single" 4 "cerebellum: 1.7" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low region specificity" "Detected in single" "Low region specificity" "Detected in all" "HPA029313, HPA029314" Uncertain Supported "Golgi apparatus" "Secreted to blood" 339700000 880000000 "Golgi apparatus" "HPA029313: AB_10669654, HPA029314: AB_10670029" "unprognostic (7.00e-2)" "unprognostic (8.37e-2)" "unprognostic (2.75e-2)" "unprognostic (2.89e-1)" "unprognostic (1.86e-1)" "unprognostic (3.26e-3)" "prognostic favourable (1.60e-4)" "unprognostic (2.92e-3)" "unprognostic (3.13e-2)" "unprognostic (4.04e-2)" "unprognostic (6.90e-3)" "unprognostic (8.30e-4)" "unprognostic (7.14e-2)" "unprognostic (3.91e-1)" "unprognostic (2.62e-2)" "unprognostic (1.05e-1)" "unprognostic (1.09e-4)" 0.3 0.2 0.3 0.4 0.3 1.8 0.3 1.7 0.5 0.3 0.3 0.3 0.3 0.3 0.4 0.3 0.3 0.4 0.3 0.3 0.3 0.1 0.3 185.1 0.3 0.6 0.3 0.3 0.5 0.4 0.0 0.3 0.3 0.3 0.3 0.0 0.3 0.7 0.3 1.4 1.4 0.5 0.3 0.3 0.6 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 1.4 1.2 1.2 0.2 0.8 1.3 0.0 0.5 0.3 2.9 1.6 0.0 0.1 0.4 0.8 0.0 0.0 0.0 1.3 1.1 2.3 0.6 0.0 0.7 0.0 0.0 0.0 0.6 2.3 1.4 2.5 20.1 0.0 2.1 1.6 0.0 0.0 0.1 0.0 0.0 0.8 0.5 0.0 0.6 0.6 1.1 0.4 0.6 1.8 1.0 0.5 0.0 1.4 1.8 0.7 0.9 0.5 0.5 0.6 1.3 1.1 0.9 0.6 1.0 0.6 0.7 1.1 1.7 0.6 1.9 0.4 1.2 0.2 1.1 0.7 0.1 1.0 0.7 0.9 0.8 0.5 1.4 1.3 1.3 0.2 0.8 0.2 1.2 0.1 0.0 0.3 0.3 1.7 0.3 0.3 0.1 0.3 0.3 0.3 0.3 MBTPS1 "KIAA0091, PCSK8, S1P, SKI-1" ENSG00000140943 "Membrane bound transcription factor peptidase, site 1" Q14703 16 84053761-84116906 "Enzymes, Predicted intracellular proteins, Predicted membrane proteins" "Cholesterol metabolism, Lipid metabolism, Steroid metabolism, Sterol metabolism" "Hydrolase, Protease, Serine protease" "Disease mutation, Dwarfism" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA056109 Supported "HPA056109: " "unprognostic (1.50e-1)" "unprognostic (9.73e-2)" "unprognostic (1.58e-1)" "unprognostic (3.10e-3)" "unprognostic (1.20e-1)" "unprognostic (1.20e-1)" "unprognostic (2.50e-1)" "unprognostic (2.02e-1)" "unprognostic (1.47e-1)" "unprognostic (1.59e-1)" "unprognostic (1.00e-2)" "unprognostic (2.19e-1)" "prognostic favourable (2.21e-5)" "unprognostic (2.62e-1)" "unprognostic (2.92e-1)" "unprognostic (6.63e-2)" "unprognostic (6.88e-2)" 26.6 25.3 15.2 17.9 32.0 13.2 27.2 29.9 30.2 27.5 23.6 20.5 21.5 15.8 33.5 22.2 18.8 29.2 20.4 31.5 15.7 18.2 23.4 28.9 22.1 17.1 14.8 15.9 34.3 32.6 47.5 38.7 28.5 15.9 24.0 21.2 33.1 29.7 26.8 16.2 18.7 19.0 25.9 11.4 21.8 23.5 17.7 16.1 24.0 36.7 16.7 23.2 26.1 19.6 10.9 11.5 12.8 14.3 14.4 16.7 15.4 15.2 19.4 17.5 24.2 41.2 33.5 13.7 25.7 39.9 22.8 17.3 13.7 22.7 14.7 26.8 36.9 16.9 15.9 17.9 25.4 13.2 17.9 10.7 18.8 19.2 19.9 25.9 23.7 34.4 25.9 21.0 18.1 29.6 13.9 13.0 13.8 26.5 14.2 14.5 16.2 13.9 18.5 9.3 10.6 18.5 12.7 13.3 16.7 49.7 13.8 19.2 43.2 23.9 31.4 23.7 17.4 14.1 12.1 16.5 30.5 28.2 17.3 15.8 14.4 6.6 14.3 12.8 15.8 12.1 16.2 10.9 13.6 14.7 11.5 9.9 16.7 14.8 4.1 14.4 9.8 6.4 8.7 15.4 15.2 32.0 29.9 30.2 15.7 18.2 14.8 15.9 15.9 16.1 MBTPS2 "KFSD, S2P" ENSG00000012174 "Membrane bound transcription factor peptidase, site 2" O43462 X 21839636-21885424 "Disease related genes, Enzymes, Potential drug targets, Predicted membrane proteins" "Cholesterol metabolism, Lipid metabolism, Steroid metabolism, Sterol metabolism" "Hydrolase, Metalloprotease, Protease" "Disease mutation, Ichthyosis, Osteogenesis imperfecta, Palmoplantar keratoderma" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA005494, CAB009486" Approved Approved Nucleoplasm,Mitochondria,Cytosol "Nucleoplasm, Mitochondria, Cytosol" "CAB009486: AB_2140370, HPA005494: AB_1079329" "unprognostic (7.97e-3)" "unprognostic (9.12e-2)" "unprognostic (5.38e-2)" "unprognostic (1.18e-2)" "unprognostic (2.65e-1)" "unprognostic (1.50e-1)" "unprognostic (1.85e-1)" "unprognostic (7.22e-2)" "unprognostic (3.32e-1)" "unprognostic (9.30e-2)" "unprognostic (1.99e-1)" "unprognostic (1.77e-1)" "unprognostic (8.38e-2)" "unprognostic (7.76e-2)" "unprognostic (1.07e-1)" "unprognostic (3.61e-1)" "unprognostic (3.05e-2)" 12.0 17.4 9.3 7.2 13.9 2.5 12.7 20.8 18.5 11.8 9.3 13.4 6.9 7.6 14.7 9.1 9.3 10.9 10.1 11.6 9.9 10.7 13.9 26.0 8.6 6.6 10.6 13.0 18.7 12.2 17.9 15.6 22.3 17.4 15.7 9.1 12.4 14.1 13.1 14.5 8.2 8.1 14.6 14.6 7.5 9.1 6.9 7.0 7.1 13.1 7.4 6.7 11.4 9.1 3.9 6.9 1.5 4.8 4.6 5.9 3.3 9.1 19.0 9.1 9.2 11.5 14.3 4.4 13.5 13.8 12.9 11.3 7.5 12.6 7.9 7.1 14.4 8.6 12.5 7.8 16.0 5.9 10.0 3.9 12.1 6.2 15.8 8.4 3.9 13.5 8.4 19.5 14.4 9.9 10.9 8.9 14.7 5.7 3.4 4.4 8.5 14.1 4.3 16.9 8.8 9.0 4.6 2.2 18.7 19.1 12.1 16.7 16.3 7.2 11.7 16.3 3.8 23.7 10.1 10.9 13.8 3.8 18.1 3.5 15.6 0.1 4.3 1.5 4.5 4.8 4.2 3.9 3.5 4.1 6.9 3.8 4.7 5.6 0.5 4.6 4.8 4.8 5.9 3.3 9.3 13.9 20.8 18.5 9.9 10.7 10.6 13.0 17.4 7.0 MEP1A PPHA ENSG00000112818 "Meprin A subunit alpha" Q16819 6 46793390-46839782 "Enzymes, Plasma proteins, Predicted membrane proteins" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 52 "intestine: 243.0" "Cell line enhanced" "Detected in some" "BEWO: 3.0;CACO-2: 6.9;Hep G2: 1.8;NB-4: 3.0;RPMI-8226: 3.4;SH-SY5Y: 2.1;U-2197: 2.0" "Cancer enriched" "Detected in many" 5 "colorectal cancer: 38.6" "Not detected" "Not detected" "Cell type enhanced" "Detected in single" "myeloid DC: 1.6" "Lineage enriched" "Detected in single" 8 "dendritic cells: 1.6" "Not detected" "Not detected" "Not detected" "Not detected" "CAB025163, HPA029416" Enhanced 990000 "CAB025163: , HPA029416: AB_10600823" "unprognostic (1.83e-1)" "unprognostic (2.81e-4)" "unprognostic (2.03e-1)" "unprognostic (8.53e-2)" "unprognostic (8.73e-2)" "unprognostic (1.13e-1)" "unprognostic (2.43e-2)" "unprognostic (5.27e-4)" "unprognostic (2.05e-1)" "unprognostic (2.35e-2)" "unprognostic (1.42e-1)" "unprognostic (2.11e-1)" "unprognostic (1.11e-3)" "unprognostic (1.45e-1)" "unprognostic (1.91e-2)" "unprognostic (4.70e-3)" "unprognostic (1.68e-1)" 0.1 0.1 0.1 4.7 0.1 0.0 0.1 0.1 0.1 0.1 100.5 0.1 0.1 51.7 0.1 0.1 0.1 0.2 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.2 0.1 0.1 0.5 0.0 0.1 0.1 0.1 0.1 19.8 0.1 0.2 0.1 0.1 0.1 243.0 0.2 0.2 0.2 0.1 0.3 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.0 1.6 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.0 0.0 0.0 0.0 0.0 6.9 0.0 0.0 0.0 0.0 0.3 0.0 0.2 0.0 0.0 0.0 0.0 0.0 1.8 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.0 0.0 0.0 0.0 0.0 3.4 0.0 0.0 0.4 2.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.6 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.1 0.1 0.1 0.1 0.1 0.1 0.2 0.1 0.1 0.1 MEP1B ENSG00000141434 "Meprin A subunit beta" Q16820 18 32185069-32220404 "Enzymes, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, Transporters" "Inflammatory response" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 167 "intestine: 241.5" "Cell line enhanced" "Detected in some" "SCLC-21H: 10.3" "Group enriched" "Detected in some" 5 "pancreatic cancer: 3.0;stomach cancer: 0.6" "Not detected" "Not detected" "Low cell type specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Not detected" "Not detected" "Low region specificity" "Detected in all" HPA029119 Enhanced "Secreted to digestive system" 120000 "HPA029119: " "unprognostic (1.33e-1)" "unprognostic (6.72e-2)" "unprognostic (2.79e-2)" "unprognostic (1.00e-1)" "unprognostic (3.50e-4)" "unprognostic (1.27e-1)" "unprognostic (1.74e-2)" "unprognostic (4.30e-1)" "unprognostic (1.73e-1)" "unprognostic (1.24e-2)" "unprognostic (1.55e-1)" "unprognostic (8.31e-4)" "unprognostic (4.74e-2)" "unprognostic (3.39e-1)" "unprognostic (2.71e-1)" "unprognostic (3.39e-2)" "unprognostic (3.75e-2)" 0.1 0.1 0.1 0.4 0.1 0.0 0.1 0.3 0.1 0.1 78.8 0.0 0.0 54.5 0.1 0.0 0.1 0.1 0.2 0.1 0.1 0.1 0.1 1.2 0.1 0.0 0.1 0.0 0.1 0.1 0.0 0.1 0.0 0.0 0.1 0.2 0.0 0.1 0.0 0.1 0.1 241.5 0.0 0.1 0.1 0.1 0.3 0.0 0.0 0.1 0.0 0.0 0.1 0.1 1.1 0.4 0.3 0.3 0.0 1.4 0.5 0.2 0.0 0.0 0.5 0.6 0.0 2.0 1.0 0.3 0.2 0.1 0.5 1.4 1.7 0.5 0.0 0.2 0.0 0.0 0.0 0.7 0.9 1.1 0.7 0.6 0.4 1.3 0.3 0.0 0.7 0.0 0.1 0.4 1.1 0.2 0.0 1.9 1.3 4.0 1.3 0.0 1.8 1.7 2.9 0.0 0.7 10.3 2.3 0.8 0.2 0.3 0.4 3.0 0.9 1.3 0.8 3.4 0.0 0.5 2.2 0.5 2.6 0.0 0.5 0.0 0.3 0.3 1.0 0.1 1.3 1.1 0.7 1.4 0.4 0.1 1.2 0.3 0.2 0.0 0.1 0.2 0.5 0.5 0.1 0.1 0.3 0.1 0.1 0.1 0.1 0.0 0.0 0.0 METAP1 "KIAA0094, MAP1A, MetAP1A" ENSG00000164024 "Methionyl aminopeptidase 1" P53582 4 98995620-99062813 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Aminopeptidase, Hydrolase, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB025485, HPA037997, HPA037998" Approved Approved "Nucleoplasm,Plasma membrane,Cytosol" 11000 Cytosol "Nucleoplasm, Plasma membrane" "CAB025485: , HPA037997: , HPA037998: " "unprognostic (1.79e-1)" "unprognostic (3.39e-1)" "prognostic favourable (7.22e-4)" "unprognostic (1.58e-2)" "unprognostic (6.53e-2)" "unprognostic (2.15e-1)" "prognostic unfavourable (3.08e-5)" "unprognostic (1.09e-1)" "unprognostic (1.51e-3)" "unprognostic (2.05e-1)" "prognostic unfavourable (2.28e-5)" "unprognostic (2.00e-1)" "prognostic favourable (1.72e-4)" "unprognostic (5.50e-2)" "unprognostic (8.51e-2)" "unprognostic (1.15e-3)" "prognostic favourable (9.31e-4)" 12.1 8.3 10.0 16.0 10.1 11.8 18.6 9.2 13.8 16.0 17.9 7.0 22.9 13.4 24.1 25.9 37.2 14.0 12.3 27.9 9.5 7.1 14.3 13.7 10.7 12.6 7.9 9.8 11.3 13.0 7.8 14.4 9.2 9.9 19.1 19.3 7.5 19.0 21.5 27.2 16.4 15.2 27.8 10.1 13.9 11.6 46.8 8.1 27.0 10.8 21.8 19.1 36.6 22.6 12.7 11.7 10.4 11.1 12.5 19.2 10.8 21.7 21.5 18.9 20.2 15.0 24.1 21.0 31.2 20.1 26.7 25.5 24.1 32.5 32.2 12.5 25.2 21.9 33.1 31.2 37.1 22.5 15.8 28.8 15.7 25.8 16.3 38.9 24.1 17.3 22.7 22.6 24.1 21.9 22.5 19.5 28.5 16.5 34.0 18.6 23.2 17.5 22.4 29.5 17.2 42.8 28.2 25.9 15.3 10.4 32.3 12.3 12.4 14.9 17.8 21.6 27.5 19.7 27.1 14.1 19.9 25.5 18.6 19.9 21.4 10.4 9.4 4.2 14.9 11.1 19.2 12.7 15.4 14.5 11.7 10.1 15.1 13.5 2.3 12.5 10.7 5.8 13.4 10.8 10.0 10.1 9.2 13.8 9.5 7.1 7.9 9.8 9.9 8.1 METAP1D "MAP1D, Metap1l" ENSG00000172878 "Methionyl aminopeptidase type 1D, mitochondrial" Q6UB28 2 171999583-172082430 "Enzymes, Predicted intracellular proteins" "Aminopeptidase, Hydrolase, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA030298, HPA030299" Uncertain Uncertain Vesicles Vesicles "HPA030298: AB_2673419, HPA030299: AB_10602421" "unprognostic (5.31e-2)" "unprognostic (1.07e-1)" "unprognostic (1.88e-1)" "unprognostic (5.83e-2)" "unprognostic (2.54e-2)" "unprognostic (7.90e-3)" "unprognostic (1.92e-3)" "unprognostic (1.07e-2)" "unprognostic (4.55e-1)" "unprognostic (7.07e-2)" "unprognostic (2.64e-2)" "unprognostic (8.19e-2)" "unprognostic (2.53e-3)" "unprognostic (3.44e-3)" "unprognostic (3.06e-2)" "unprognostic (5.48e-3)" "unprognostic (2.92e-2)" 7.1 7.5 7.2 8.0 8.4 6.3 8.2 6.7 9.2 6.5 6.1 9.6 6.5 5.0 9.0 6.4 5.2 10.3 4.5 6.4 6.0 4.9 5.4 8.3 3.6 8.1 9.3 7.1 18.9 23.8 5.5 13.8 4.1 8.6 8.3 7.1 7.3 9.7 10.3 13.8 7.1 5.9 10.0 7.2 8.6 6.3 5.9 9.5 2.1 5.6 6.3 6.7 5.4 5.7 2.5 0.5 0.2 1.2 1.2 3.6 0.7 3.3 2.6 3.9 13.0 5.8 7.5 8.0 3.8 3.9 6.2 3.9 6.0 4.4 1.7 7.0 4.0 6.1 8.5 6.7 6.3 5.9 10.1 9.4 6.9 7.9 6.2 5.5 2.5 5.7 10.6 6.1 9.9 3.5 13.5 4.8 4.6 4.1 3.1 7.5 7.1 3.2 7.1 3.4 3.0 4.4 4.6 8.1 3.1 2.7 5.6 9.5 6.4 7.5 4.1 7.9 6.3 4.8 3.6 6.0 5.4 3.8 5.6 11.1 7.5 0.0 0.2 0.0 1.3 1.2 0.6 1.2 1.9 0.7 0.5 2.5 1.9 3.6 0.2 1.2 0.2 0.0 1.4 0.7 7.2 8.4 6.7 9.2 6.0 4.9 9.3 7.1 8.6 9.5 METAP2 "MAP2, MNPEP, p67" ENSG00000111142 "Methionyl aminopeptidase 2" P50579 12 95473520-95515839 "Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins" "Aminopeptidase, Hydrolase, Protease" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB013025, HPA019095" Enhanced Supported "Plasma membrane,Cytosol" 22000 "Plasma membrane, Cytosol" "CAB013025: AB_2533993, HPA019095: AB_1853823" "unprognostic (1.91e-1)" "unprognostic (1.02e-1)" "unprognostic (5.92e-2)" "unprognostic (2.44e-1)" "unprognostic (3.27e-2)" "unprognostic (2.57e-2)" "prognostic unfavourable (4.51e-6)" "unprognostic (1.25e-1)" "unprognostic (2.28e-2)" "unprognostic (1.40e-2)" "unprognostic (8.53e-2)" "unprognostic (1.66e-1)" "unprognostic (1.49e-1)" "unprognostic (2.51e-1)" "unprognostic (1.07e-1)" "unprognostic (2.95e-2)" "unprognostic (1.03e-1)" 24.2 36.4 25.8 49.9 33.7 39.1 25.1 25.9 32.3 23.9 26.2 16.3 102.5 16.6 28.7 25.4 30.1 22.5 21.7 30.7 29.6 24.0 26.0 46.8 22.1 32.6 29.1 23.4 29.4 31.9 21.0 36.1 25.1 42.9 24.2 24.0 10.1 22.1 140.7 94.4 28.7 19.7 26.1 48.2 25.2 22.2 26.3 27.7 32.1 24.1 29.0 55.2 33.4 37.3 39.4 31.8 21.3 27.1 25.7 32.0 16.2 33.2 28.1 30.1 23.3 18.3 29.4 23.1 32.8 23.0 32.4 23.0 40.8 16.0 97.0 20.7 23.4 21.5 33.8 25.1 37.3 23.0 29.1 43.4 21.4 28.7 19.6 53.7 21.3 25.4 26.9 30.6 30.1 34.4 56.1 11.0 24.0 21.9 39.7 36.7 36.8 42.0 31.3 26.0 31.8 22.2 35.4 23.4 30.7 29.2 23.9 28.7 28.8 25.6 29.5 18.6 18.1 20.8 34.6 15.9 41.4 104.0 10.6 30.3 23.4 21.3 27.1 11.1 23.8 19.1 29.2 39.4 26.7 26.6 24.4 37.6 32.0 29.7 1.2 25.7 22.3 31.8 25.3 16.2 25.8 33.7 25.9 32.3 29.6 24.0 29.1 23.4 42.9 27.7 MINDY1 "FAM63A, FLJ11280, MINDY-1" ENSG00000143409 "MINDY lysine 48 deubiquitinase 1" Q8N5J2 1 150996086-151008375 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell line enhanced" "Detected in many" "T-47d: 27.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 6 "basophil: 26.3;eosinophil: 19.1;neutrophil: 30.4" "Lineage enriched" "Detected in many" 7 "granulocytes: 30.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA028351, HPA028358, HPA061086" Approved Enhanced Nucleoplasm 240000 Nucleoplasm "HPA028351: AB_10611110, HPA028358: AB_10601102, HPA061086: " "unprognostic (5.73e-2)" "unprognostic (2.86e-1)" "unprognostic (5.47e-2)" "unprognostic (3.14e-1)" "unprognostic (3.39e-2)" "unprognostic (6.90e-2)" "unprognostic (1.47e-2)" "unprognostic (1.64e-1)" "unprognostic (1.02e-1)" "unprognostic (1.88e-1)" "unprognostic (9.22e-3)" "unprognostic (1.06e-1)" "prognostic favourable (3.43e-8)" "unprognostic (2.30e-1)" "unprognostic (7.95e-2)" "unprognostic (2.50e-2)" "unprognostic (6.06e-2)" 9.2 9.7 14.0 6.7 31.1 5.6 13.0 18.4 21.2 13.1 13.5 53.8 14.8 14.0 14.7 6.5 24.1 14.4 11.8 24.5 17.6 10.1 26.6 12.2 10.9 5.2 37.5 13.5 19.3 37.3 26.2 12.3 5.9 25.0 11.7 14.8 16.9 25.3 21.0 11.9 17.1 12.1 13.7 34.1 10.7 15.9 14.7 35.7 0.9 39.9 7.9 10.3 12.3 13.0 0.6 4.0 30.4 3.2 1.5 2.2 3.4 6.0 4.0 4.3 6.0 7.7 6.4 3.6 2.0 5.0 2.8 4.5 8.5 14.5 0.3 4.7 2.5 3.0 3.4 3.7 1.3 4.6 5.1 5.9 7.3 7.2 1.7 1.7 2.4 5.2 3.4 5.0 1.4 7.1 3.6 15.3 2.9 9.3 0.3 4.0 2.0 1.4 4.4 0.7 18.7 13.2 12.1 7.4 5.4 3.8 6.9 4.2 27.6 6.0 6.6 2.4 3.1 1.2 1.7 5.6 5.1 20.4 5.8 3.9 11.3 26.3 3.2 19.1 0.1 1.5 0.1 0.3 1.3 0.3 4.0 0.6 2.2 0.7 30.4 1.5 0.9 0.6 1.6 3.4 14.0 31.1 18.4 21.2 17.6 10.1 37.5 13.5 25.0 35.7 MINDY2 "FAM63B, KIAA1164" ENSG00000128923 "MINDY lysine 48 deubiquitinase 2" Q8NBR6 15 58771192-58861900 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell line enhanced" "Detected in many" "U-2197: 39.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA051103, HPA063669" Approved Enhanced Nucleoplasm Nucleoplasm "HPA051103: , HPA063669: " "unprognostic (4.71e-2)" "unprognostic (8.92e-3)" "unprognostic (4.63e-2)" "unprognostic (4.13e-2)" "unprognostic (1.32e-1)" "unprognostic (1.06e-1)" "unprognostic (2.14e-1)" "unprognostic (8.60e-2)" "unprognostic (7.23e-2)" "unprognostic (7.09e-2)" "unprognostic (2.36e-3)" "unprognostic (4.74e-2)" "prognostic favourable (3.00e-8)" "unprognostic (2.53e-1)" "unprognostic (3.59e-1)" "unprognostic (6.76e-2)" "unprognostic (4.77e-2)" 14.0 9.2 15.5 8.8 14.7 5.6 11.1 41.0 15.4 12.4 8.8 12.4 11.8 5.8 13.0 8.0 11.8 11.7 10.4 16.7 14.6 12.6 16.9 5.8 12.5 6.1 16.2 15.5 11.7 6.4 15.5 12.5 21.9 14.9 15.0 6.6 11.7 7.7 11.8 6.1 11.4 6.5 13.6 16.9 9.4 7.8 6.2 15.8 8.6 15.8 5.4 6.0 13.1 9.1 4.6 2.9 5.5 3.1 1.9 5.5 1.4 5.7 2.8 4.0 2.4 6.1 11.2 6.4 5.3 11.3 1.6 2.4 4.5 2.9 2.9 5.8 6.3 5.6 7.3 4.3 2.6 3.0 2.6 4.1 3.1 4.0 3.7 3.1 3.8 4.9 7.2 1.9 4.5 4.0 7.1 3.3 3.9 0.7 3.8 2.3 8.6 1.5 1.7 11.6 3.1 4.9 6.5 3.7 2.7 3.8 5.4 9.6 1.6 6.6 4.7 2.3 2.1 39.9 2.3 3.0 4.2 2.9 5.2 5.1 5.6 5.5 1.8 3.3 3.2 1.6 5.5 2.7 2.8 3.5 0.6 4.6 2.4 3.3 3.9 1.9 3.1 2.9 2.2 1.4 15.5 14.7 41.0 15.4 14.6 12.6 16.2 15.5 14.9 15.8 MINDY3 "C10orf97, CARP, DERP5, FAM188A, FLJ13397, my042" ENSG00000148481 "MINDY lysine 48 deubiquitinase 3" Q9H8M7 10 15778170-15860520 "Enzymes, Predicted intracellular proteins" "Apoptosis, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA038400, HPA038406" Uncertain Supported "Nucleoplasm,Nuclear membrane" "Nucleoplasm, Nuclear membrane" "HPA038400: AB_10669724, HPA038406: " "unprognostic (9.20e-2)" "unprognostic (5.84e-2)" "unprognostic (3.09e-1)" "unprognostic (3.26e-1)" "unprognostic (1.99e-2)" "unprognostic (3.67e-1)" "unprognostic (8.29e-2)" "unprognostic (2.81e-2)" "unprognostic (3.85e-2)" "unprognostic (9.63e-2)" "unprognostic (6.48e-3)" "unprognostic (6.50e-2)" "unprognostic (1.32e-1)" "unprognostic (2.97e-1)" "unprognostic (1.04e-2)" "unprognostic (1.76e-1)" "unprognostic (3.19e-1)" 14.6 22.0 17.9 10.0 22.2 15.2 18.4 22.0 32.0 19.1 13.7 19.7 11.4 8.2 18.6 20.0 13.4 15.3 13.3 8.9 20.1 18.8 16.0 15.8 15.5 11.9 22.9 14.0 18.1 12.8 16.3 14.4 20.1 25.8 18.9 18.0 13.5 11.8 16.5 4.1 15.3 11.4 16.7 32.0 11.8 14.6 18.8 16.1 10.5 17.2 7.7 12.6 17.8 14.1 3.4 4.2 5.7 8.0 3.4 6.2 2.9 6.5 6.1 11.9 12.6 17.6 16.8 9.8 20.9 10.6 16.0 18.7 5.3 10.3 4.9 4.0 22.5 6.1 10.1 12.4 14.3 14.9 14.1 15.9 8.7 5.7 22.2 3.2 13.4 12.6 10.9 14.2 10.1 12.5 9.7 4.1 15.8 7.1 6.9 3.9 4.3 11.7 3.4 7.0 3.4 17.8 4.9 9.8 10.9 10.2 9.9 8.3 11.1 7.9 13.2 10.4 8.0 17.5 6.0 22.6 9.6 8.4 11.9 7.3 8.3 5.7 3.6 3.1 4.9 7.1 4.1 3.1 3.4 5.2 4.0 3.4 2.3 4.4 3.1 3.4 8.0 4.2 6.2 2.9 17.9 22.2 22.0 32.0 20.1 18.8 22.9 14.0 25.8 16.1 MINDY4 "C7orf67, FAM188B, FLJ22374" ENSG00000106125 "MINDY lysine 48 deubiquitinase 4" Q4G0A6 7 30771417-30892387 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell line enhanced" "Detected in many" "K-562: 16.2" "Low cancer specificity" "Detected in single" "Low region specificity" "Detected in all" "Cell type enhanced" "Detected in some" "MAIT T-cell: 2.7" "Group enriched" "Detected in many" 5 "dendritic cells: 1.1;T-cells: 2.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" "HPA019475, HPA030129, HPA030130" Approved Supported Vesicles,Cytosol "Vesicles, Cytosol" "HPA019475: AB_1848806, HPA030129: AB_10599621, HPA030130: AB_10601565" "unprognostic (2.96e-1)" "unprognostic (1.27e-1)" "unprognostic (2.62e-1)" "unprognostic (2.10e-2)" "unprognostic (1.64e-1)" "unprognostic (4.07e-1)" "unprognostic (6.01e-3)" "unprognostic (3.81e-2)" "unprognostic (5.25e-3)" "unprognostic (1.97e-1)" "unprognostic (5.59e-3)" "unprognostic (2.96e-2)" "unprognostic (1.92e-1)" "unprognostic (9.55e-2)" "unprognostic (1.12e-2)" "unprognostic (1.05e-1)" "unprognostic (2.18e-1)" 9.3 6.7 9.3 2.6 15.2 4.1 7.0 3.4 15.1 10.8 6.6 5.4 16.6 2.9 15.6 16.2 5.7 20.7 10.0 7.5 8.4 5.1 9.4 3.8 14.2 2.4 4.3 9.5 14.8 5.6 9.6 16.1 6.2 9.0 9.4 4.3 7.8 5.3 15.9 3.7 5.1 3.7 10.8 3.6 2.3 5.8 20.1 5.0 1.5 12.5 3.6 2.2 6.4 6.3 0.0 1.1 0.0 0.3 0.0 2.7 0.7 2.1 5.3 2.7 8.4 2.4 9.5 4.1 3.1 5.3 2.3 2.0 0.0 3.9 0.0 3.6 2.0 2.2 1.8 1.7 2.2 0.0 3.1 1.6 2.8 0.0 3.1 2.3 1.2 4.8 2.8 7.0 1.4 3.4 16.2 1.0 2.0 0.0 1.2 0.7 7.9 1.2 0.4 0.0 0.5 6.3 1.0 5.1 7.0 2.1 11.2 1.2 5.7 1.7 2.0 0.1 1.3 2.4 1.3 2.3 2.9 0.0 4.4 0.1 9.8 0.0 0.1 0.0 0.6 0.0 2.7 0.0 0.8 0.2 1.1 0.0 0.3 0.5 0.0 0.0 0.3 0.0 0.5 0.7 9.3 15.2 3.4 15.1 8.4 5.1 4.3 9.5 9.0 5.0 MIPEP MIP ENSG00000027001 "Mitochondrial intermediate peptidase" Q99797 13 23730189-23889419 "Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Hydrolase, Metalloprotease, Protease" "Disease mutation, Primary mitochondrial disease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA030676, HPA031669, HPA031670" Approved Enhanced Mitochondria Mitochondria "HPA030676: AB_10598907, HPA031669: AB_10600986, HPA031670: AB_10602198" "unprognostic (2.05e-1)" "unprognostic (3.17e-2)" "unprognostic (3.75e-3)" "unprognostic (3.72e-2)" "unprognostic (1.24e-1)" "unprognostic (1.23e-1)" "unprognostic (2.41e-1)" "unprognostic (2.21e-1)" "unprognostic (4.69e-2)" "unprognostic (1.12e-1)" "unprognostic (7.54e-2)" "unprognostic (4.76e-1)" "prognostic favourable (7.66e-12)" "unprognostic (1.62e-2)" "unprognostic (4.95e-2)" "unprognostic (2.79e-1)" "unprognostic (6.90e-3)" 7.3 14.9 6.2 7.1 12.2 4.4 11.0 4.7 10.3 8.1 12.2 12.9 12.1 8.4 9.6 20.4 14.4 17.1 11.7 16.9 8.8 5.3 24.7 12.0 8.2 8.4 5.1 8.0 8.5 14.7 8.1 15.4 5.3 9.1 10.9 13.1 9.1 12.9 10.1 16.2 22.0 8.9 11.5 4.4 6.5 9.8 13.9 4.9 8.9 10.9 15.7 11.1 11.2 8.6 9.2 6.5 1.2 10.6 9.7 10.0 3.9 8.9 10.1 5.0 11.7 11.5 15.5 10.7 6.5 10.1 9.8 8.2 13.4 17.8 10.5 6.6 5.2 22.6 11.5 13.6 12.2 6.1 7.3 4.6 4.8 11.5 9.4 10.7 2.5 7.6 17.1 10.1 9.0 12.2 8.8 1.7 15.2 6.6 7.6 6.0 6.9 10.2 8.5 13.5 9.1 21.8 6.0 11.8 3.9 6.9 11.4 13.6 11.7 6.0 6.7 6.0 5.0 9.8 6.9 1.7 2.4 5.6 10.3 5.5 7.4 0.0 3.0 1.2 7.9 3.7 10.0 9.2 7.7 7.1 6.5 7.7 7.4 7.3 0.0 9.7 10.6 5.6 5.1 3.9 6.2 12.2 4.7 10.3 8.8 5.3 5.1 8.0 9.1 4.9 MME "CALLA, CD10, NEP" ENSG00000196549 "Membrane metalloendopeptidase" P08473 3 155024124-155183729 "Cancer-related genes, Candidate cardiovascular disease genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Metalloprotease, Protease" "Cancer-related genes, Charcot-Marie-Tooth disease, Disease mutation, FDA approved drug targets, Neurodegeneration, Neuropathy, Spinocerebellar ataxia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "blood: 61.1;intestine: 136.0;kidney: 64.9" "Cell line enhanced" "Detected in many" "ASC TERT1: 95.0;BJ hTERT+: 142.9;HSkMC: 92.1" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Cell type enriched" "Detected in single" 129 "neutrophil: 61.1" "Lineage enriched" "Detected in single" 129 "granulocytes: 61.1" "Low region specificity" "Detected in many" "Region enhanced" "Detected in many" "basal ganglia: 26.8" "CAB000013, HPA052583, HPA056072" Enhanced 99000 "CAB000013: AB_563478, HPA052583: AB_2681872, HPA056072: AB_2683027" "unprognostic (1.36e-1)" "unprognostic (1.02e-3)" "unprognostic (8.52e-2)" "unprognostic (2.95e-1)" "unprognostic (2.78e-2)" "unprognostic (6.52e-3)" "unprognostic (1.20e-1)" "unprognostic (1.67e-2)" "unprognostic (8.67e-2)" "unprognostic (1.96e-1)" "unprognostic (7.30e-3)" "unprognostic (1.31e-1)" "unprognostic (2.71e-3)" "unprognostic (1.50e-1)" "unprognostic (7.29e-2)" "unprognostic (1.06e-2)" "unprognostic (1.37e-2)" 26.5 0.4 0.4 3.4 7.4 1.9 14.7 0.4 0.7 4.8 65.6 0.1 18.4 74.0 2.8 8.1 0.7 0.9 8.5 1.8 0.3 0.4 64.9 11.5 13.7 3.0 2.1 0.2 0.9 0.6 0.0 0.6 35.0 8.6 18.3 0.4 1.3 3.7 11.3 11.7 1.4 136.0 0.6 0.9 2.7 0.7 1.0 1.2 13.2 1.0 5.3 2.3 3.4 4.9 0.1 0.4 61.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 38.6 95.0 0.2 21.2 142.9 10.8 28.1 0.0 0.0 23.4 0.0 18.8 0.0 0.7 0.8 26.1 0.0 0.1 0.0 0.0 0.0 30.9 0.0 0.0 92.1 0.1 5.8 41.6 8.2 0.0 0.0 17.3 0.1 0.0 0.1 0.9 0.1 38.8 18.2 0.1 0.6 0.2 0.0 0.2 0.0 0.0 4.1 0.0 0.0 23.3 46.7 0.1 15.9 3.7 0.0 0.0 30.8 5.6 0.0 1.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 61.1 0.0 0.0 0.4 0.0 0.0 0.4 7.4 0.4 0.7 0.3 0.4 2.1 0.2 8.6 1.2 MMEL1 "MMEL2, NEPII, NL1, NL2, SEP" ENSG00000142606 "Membrane metalloendopeptidase like 1" Q495T6 1 2590639-2632990 "Enzymes, Predicted intracellular proteins" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "testis: 30.2" "Cell line enriched" "Detected in some" 5 "SK-BR-3: 17.4" "Low cancer specificity" "Detected in many" "Region enhanced" "Detected in many" "basal ganglia: 8.5" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "HPA007876, HPA008205, CAB020786" Uncertain "Intracellular and membrane" "CAB020786: , HPA007876: AB_1854012, HPA008205: AB_1854011" "unprognostic (5.80e-2)" "unprognostic (4.61e-2)" "unprognostic (1.87e-1)" "unprognostic (4.27e-2)" "unprognostic (1.33e-1)" "unprognostic (2.71e-2)" "unprognostic (1.45e-1)" "unprognostic (7.96e-2)" "unprognostic (1.36e-2)" "unprognostic (2.37e-1)" "unprognostic (4.54e-3)" "unprognostic (2.44e-2)" "unprognostic (4.79e-2)" "unprognostic (3.18e-1)" "unprognostic (2.82e-1)" "unprognostic (2.18e-3)" "unprognostic (7.01e-4)" 1.5 0.5 0.8 1.8 8.5 0.6 1.8 0.4 0.6 4.3 4.2 0.4 1.9 3.2 0.8 10.3 3.0 3.0 9.6 1.3 1.0 2.6 1.4 0.4 1.4 1.4 1.7 0.4 1.1 7.3 0.3 0.4 0.7 0.5 4.2 1.4 0.4 2.0 2.0 0.4 0.3 2.6 0.9 0.7 1.4 7.9 30.2 0.9 0.8 1.1 0.8 0.8 3.7 1.6 0.6 1.1 6.6 5.1 2.3 6.1 2.2 0.0 0.0 0.0 0.0 0.0 0.1 0.3 0.0 0.0 0.0 0.0 0.0 2.9 0.0 3.1 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.2 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 2.9 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.6 0.0 0.5 0.0 17.4 0.0 1.6 0.0 0.2 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.4 1.5 6.6 0.5 3.9 0.3 0.6 1.7 0.7 1.1 0.0 4.5 2.2 1.0 2.3 5.1 0.2 6.1 2.2 0.8 8.5 0.4 0.6 1.0 2.6 1.7 0.4 0.5 0.9 MMP1 CLG ENSG00000196611 "Matrix metallopeptidase 1" P03956 11 102789920-102798160 "Cancer-related genes, Candidate cardiovascular disease genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins" "Collagen degradation, Host-virus interaction" "Hydrolase, Metalloprotease, Protease" "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "gallbladder: 62.4;stomach 1: 27.2" "Cell line enhanced" "Detected in some" "BJ hTERT+: 88.1;HBF TERT88: 87.3;HUVEC TERT2: 229.4;WM-115: 113.0" "Cancer enhanced" "Detected in many" "head and neck cancer: 344.2" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA004920 Approved Vesicles "Secreted to extracellular matrix" 430000 Vesicles "HPA004920: " "unprognostic (4.11e-3)" "prognostic unfavourable (4.66e-4)" "unprognostic (4.20e-3)" "unprognostic (1.19e-3)" "unprognostic (6.46e-2)" "unprognostic (6.50e-2)" "prognostic unfavourable (4.22e-6)" "unprognostic (7.83e-3)" "unprognostic (2.94e-2)" "unprognostic (5.44e-2)" "unprognostic (1.11e-3)" "unprognostic (1.75e-1)" "prognostic unfavourable (9.86e-10)" "unprognostic (1.67e-2)" "unprognostic (1.49e-1)" "unprognostic (1.26e-2)" "unprognostic (5.11e-2)" 0.2 0.1 0.3 12.3 0.3 0.0 0.9 0.3 0.3 0.3 2.7 0.3 0.2 3.2 4.8 0.2 3.3 0.1 62.4 0.4 0.2 0.1 0.7 1.3 4.7 0.2 0.2 0.2 0.2 1.6 0.0 0.2 8.6 0.5 0.7 3.0 0.3 2.0 0.2 0.2 0.3 8.8 0.2 0.4 1.8 27.2 2.2 0.2 0.4 0.3 1.3 0.9 11.0 0.2 0.0 0.0 0.6 0.0 0.0 0.0 1.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 39.9 88.1 36.0 9.4 0.7 0.0 0.0 0.4 21.1 0.3 0.0 12.3 87.3 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 37.0 3.1 229.4 0.1 0.0 0.0 0.0 0.0 0.0 0.0 1.6 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.3 0.0 0.1 0.0 0.0 11.9 29.9 0.0 1.3 0.1 0.0 0.0 0.0 0.7 0.0 113.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 1.9 0.3 0.3 0.3 0.3 0.2 0.1 0.2 0.2 0.5 0.2 MMP10 STMY2 ENSG00000166670 "Matrix metallopeptidase 10" P09238 11 102770503-102780628 "Cancer-related genes, Enzymes, FDA approved drug targets, Predicted secreted proteins" "Collagen degradation" "Hydrolase, Metalloprotease, Protease" "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 4 "endometrium 1: 89.4" "Cell line enhanced" "Detected in some" "BJ: 12.3;HUVEC TERT2: 15.8;SCLC-21H: 5.0" "Cancer enhanced" "Detected in many" "head and neck cancer: 102.2" "Region enriched" "Detected in single" 9 "pons and medulla: 2.8" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" CAB002159 Uncertain Approved "Plasma membrane,Cytosol" "Secreted to extracellular matrix" Cytosol "Plasma membrane" "CAB002159: AB_564103" "unprognostic (8.76e-2)" "unprognostic (3.38e-1)" "unprognostic (1.98e-3)" "unprognostic (2.72e-3)" "unprognostic (7.17e-3)" "unprognostic (1.52e-2)" "unprognostic (5.67e-8)" "unprognostic (2.08e-3)" "unprognostic (2.20e-1)" "unprognostic (1.75e-1)" "unprognostic (1.67e-2)" "unprognostic (2.67e-1)" "unprognostic (6.99e-5)" "unprognostic (2.66e-2)" "unprognostic (7.98e-2)" "unprognostic (5.46e-2)" "prognostic favourable (7.12e-4)" 0.1 0.1 0.0 2.6 0.2 0.1 0.1 0.0 0.3 1.7 0.5 0.0 0.0 0.4 89.4 0.1 0.2 0.1 0.5 0.1 0.0 0.1 0.1 3.6 11.0 0.1 0.0 0.0 0.5 0.3 0.1 0.9 19.8 2.8 3.2 0.2 0.0 2.9 0.1 0.1 0.1 0.7 0.1 0.0 0.2 3.3 0.5 0.0 1.2 0.1 0.0 1.9 0.6 5.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.8 0.2 0.0 0.0 0.2 12.3 0.7 0.1 0.1 0.3 0.0 0.0 3.6 1.9 2.8 0.0 1.4 0.0 0.0 0.2 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.2 0.4 0.6 15.8 0.7 0.0 0.0 0.0 0.0 0.3 2.9 1.7 0.0 0.0 0.0 0.0 0.7 5.0 0.0 2.5 0.0 0.0 0.0 0.0 2.0 3.8 1.2 0.4 0.5 0.0 0.0 0.0 0.6 0.0 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.3 0.0 0.1 0.0 0.0 2.8 0.0 MMP11 STMY3 ENSG00000099953 "Matrix metallopeptidase 11" P24347 22 23768226-23784316 "Cancer-related genes, Enzymes, FDA approved drug targets, Predicted secreted proteins" "Collagen degradation" "Hydrolase, Metalloprotease, Protease" "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 6 "endometrium 1: 44.1;placenta: 119.6" "Cell line enhanced" "Detected in some" "AN3-CA: 18.9;BJ hTERT+: 5.1;REH: 7.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in single" "Cell type enhanced" "Detected in some" "plasmacytoid DC: 7.8" "Group enriched" "Detected in many" 5 "B-cells: 2.4;dendritic cells: 7.8" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "CAB002593, HPA068864" Approved "Secreted to extracellular matrix" "CAB002593: , HPA068864: " "unprognostic (1.06e-1)" "unprognostic (3.08e-1)" "unprognostic (1.83e-1)" "unprognostic (1.84e-3)" "unprognostic (2.77e-2)" "unprognostic (6.73e-2)" "unprognostic (2.14e-2)" "unprognostic (5.15e-1)" "unprognostic (2.73e-2)" "unprognostic (2.20e-1)" "unprognostic (1.89e-3)" "unprognostic (7.04e-2)" "prognostic unfavourable (2.62e-4)" "unprognostic (8.05e-2)" "unprognostic (6.78e-2)" "unprognostic (1.10e-1)" "unprognostic (1.68e-2)" 1.7 0.6 0.2 1.0 0.6 0.1 1.6 1.0 0.5 13.4 1.8 0.4 0.4 1.9 44.1 1.1 0.8 2.2 2.0 3.1 0.5 0.0 1.7 0.5 0.7 1.8 0.4 0.2 7.7 1.1 0.2 0.3 119.6 0.5 1.4 1.0 0.8 2.5 0.4 0.5 2.0 4.0 2.7 0.3 0.9 0.7 3.4 0.2 2.6 0.5 0.6 0.9 1.6 2.1 2.4 7.8 0.0 0.0 0.0 1.0 0.1 0.1 0.0 2.3 18.9 2.9 4.2 0.0 0.2 5.1 0.6 0.4 0.0 0.6 0.6 3.5 1.3 0.1 1.0 0.0 0.2 0.0 0.3 0.0 0.0 1.0 2.1 0.0 0.0 2.7 0.4 0.5 0.0 3.0 0.3 0.0 0.7 0.1 0.0 0.0 0.7 0.1 7.9 0.0 0.2 0.3 0.0 3.0 5.1 1.9 0.3 0.0 1.8 0.0 1.3 0.3 0.0 0.8 0.0 0.1 0.1 2.5 0.1 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 1.3 0.0 0.0 0.0 2.4 1.0 0.3 0.0 0.0 0.0 7.8 0.0 0.1 0.2 0.6 1.0 0.5 0.5 0.0 0.4 0.2 0.5 0.2 MMP12 HME ENSG00000262406 "Matrix metallopeptidase 12" P39900 11 102862736-102875034 "Cancer-related genes, Enzymes, FDA approved drug targets, Predicted secreted proteins" "Hydrolase, Metalloprotease, Protease" "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "lymphoid tissue: 42.4;urinary bladder: 13.2" "Group enriched" "Detected in some" 12 "BJ: 4.1;fHDF/TERT166: 14.3;hTEC/SVTERT24-B: 8.2" "Low cancer specificity" "Detected in all" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in single" "Secreted to extracellular matrix" "unprognostic (7.33e-2)" "unprognostic (3.20e-2)" "unprognostic (1.00e-2)" "unprognostic (1.03e-1)" "unprognostic (2.74e-1)" "unprognostic (1.67e-1)" "prognostic unfavourable (1.42e-4)" "unprognostic (1.69e-2)" "unprognostic (7.31e-2)" "unprognostic (1.52e-2)" "unprognostic (1.52e-3)" "unprognostic (5.45e-2)" "unprognostic (3.05e-6)" "unprognostic (1.08e-2)" "unprognostic (4.66e-2)" "unprognostic (1.73e-1)" "unprognostic (6.92e-2)" 2.7 0.0 0.0 21.2 0.0 0.0 0.0 0.0 0.0 0.3 6.9 0.0 0.0 3.3 0.0 5.9 0.0 0.0 1.0 0.0 0.0 0.0 0.4 0.6 18.9 0.0 0.0 0.1 0.0 0.0 0.0 9.7 0.0 0.3 8.4 0.0 0.9 0.0 0.0 0.0 3.8 4.6 0.0 42.4 1.3 0.1 0.0 5.5 0.0 1.5 9.9 13.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.1 0.4 0.2 0.0 0.1 0.0 0.0 0.0 14.3 0.5 0.0 0.0 0.4 0.4 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 8.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.4 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.5 0.6 0.2 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 MMP13 CLG3 ENSG00000137745 "Matrix metallopeptidase 13" P45452 11 102942995-102955734 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins" "Collagen degradation" "Hydrolase, Metalloprotease, Protease" "Cancer-related genes, Disease mutation, Dwarfism, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "lung: 12.6;vagina: 10.8" "Group enriched" "Detected in some" 5 "HaCaT: 19.1;PC-3: 7.2" "Cancer enhanced" "Detected in many" "head and neck cancer: 70.9" "Not detected" "Not detected" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Not detected" "Not detected" "Not detected" "Not detected" CAB002742 Supported "Secreted to extracellular matrix" "CAB002742: " "unprognostic (8.98e-3)" "unprognostic (1.54e-1)" "unprognostic (4.75e-2)" "unprognostic (4.57e-2)" "unprognostic (3.05e-2)" "unprognostic (1.59e-3)" "unprognostic (1.32e-1)" "unprognostic (6.35e-3)" "unprognostic (1.69e-1)" "unprognostic (7.55e-3)" "unprognostic (2.24e-1)" "unprognostic (1.73e-8)" "unprognostic (2.12e-2)" "unprognostic (3.14e-1)" "unprognostic (4.14e-2)" "unprognostic (4.33e-2)" 0.5 0.1 0.0 0.8 0.0 1.3 0.4 0.0 0.2 1.3 0.1 0.0 0.0 0.6 0.1 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.2 0.1 12.6 0.1 0.0 0.0 0.1 0.0 0.0 3.1 0.1 0.1 1.2 0.0 0.0 0.6 0.0 0.0 1.0 0.5 0.0 0.0 0.1 0.1 1.9 0.0 1.4 0.0 0.0 0.1 4.6 10.8 1.0 0.7 2.7 0.5 1.9 1.3 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.4 0.0 0.0 0.0 0.3 0.0 0.0 0.0 19.1 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.1 0.0 0.5 0.1 0.0 0.0 7.2 0.0 0.0 0.1 0.0 1.9 0.0 0.1 0.1 2.2 0.0 0.0 0.0 0.0 2.7 1.4 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 2.7 0.5 0.6 1.3 0.4 1.0 0.5 0.7 0.8 0.3 1.0 0.6 1.1 1.9 1.9 0.3 0.7 0.4 0.5 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.1 0.0 MMP14 MT1-MMP ENSG00000157227 "Matrix metallopeptidase 14" P50281 14 22836557-22849027 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Metalloprotease, Protease" "Cancer-related genes, Disease mutation, FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell line enhanced" "Detected in many" "ASC diff: 98.0;HHSteC: 92.7;HSkMC: 94.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB009918, HPA051432" Approved Approved "Intermediate filaments,Cytosol" 570000 Cytosol "Intermediate filaments" "CAB009918: AB_2250767, HPA051432: " "unprognostic (1.34e-1)" "unprognostic (1.37e-1)" "unprognostic (1.11e-2)" "unprognostic (2.81e-1)" "unprognostic (4.28e-2)" "unprognostic (1.12e-2)" "unprognostic (3.05e-3)" "unprognostic (5.91e-3)" "unprognostic (1.95e-1)" "prognostic unfavourable (9.48e-4)" "unprognostic (3.82e-3)" "unprognostic (7.31e-2)" "prognostic unfavourable (1.34e-4)" "unprognostic (5.02e-2)" "unprognostic (6.69e-2)" "unprognostic (1.00e-2)" "unprognostic (3.41e-3)" 60.9 10.5 2.4 16.6 4.7 0.2 64.2 2.2 3.2 56.3 35.0 8.2 12.7 12.0 53.1 24.1 47.0 21.9 39.6 17.5 3.4 1.8 16.8 9.0 29.8 16.9 5.8 2.9 39.3 11.2 34.4 4.7 73.5 16.4 39.1 11.3 27.1 24.4 16.7 20.4 37.0 22.9 28.5 20.7 22.5 18.2 26.3 4.6 5.4 22.3 14.6 16.7 52.5 53.9 0.1 0.7 0.0 0.7 0.0 0.0 0.1 7.9 0.1 2.4 0.1 98.0 62.3 45.0 25.1 50.6 7.6 13.6 2.3 29.9 0.1 14.0 26.4 20.3 0.0 26.1 9.8 0.1 0.1 3.7 0.1 0.5 92.7 0.0 0.1 94.2 15.8 31.7 27.2 46.0 0.1 0.2 17.9 0.1 0.0 9.0 1.5 4.3 0.3 8.6 0.0 6.9 13.7 0.0 0.0 16.4 0.0 54.4 0.1 8.1 40.7 61.9 5.3 18.0 28.6 0.1 0.1 0.1 37.7 0.0 35.8 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 2.4 4.7 2.2 3.2 3.4 1.8 5.8 2.9 16.4 4.6 MMP15 "MT2-MMP, MTMMP2, SMCP-2" ENSG00000102996 "Matrix metallopeptidase 15" P51511 16 58025566-58046901 "Cancer-related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Metalloprotease, Protease" "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 43.2" "Cell line enhanced" "Detected in many" "BEWO: 36.8;Hep G2: 19.1;SK-BR-3: 18.5;WM-115: 30.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Cell type enriched" "Detected in single" 30 "plasmacytoid DC: 2.9" "Lineage enriched" "Detected in single" 30 "dendritic cells: 2.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB002611, HPA040390" Uncertain Approved "Nucleoplasm,Plasma membrane,Cytosol" "Plasma membrane, Cytosol" Nucleoplasm "CAB002611: , HPA040390: " "unprognostic (1.76e-2)" "unprognostic (7.32e-2)" "unprognostic (2.69e-1)" "unprognostic (6.85e-2)" "unprognostic (3.09e-1)" "unprognostic (1.68e-1)" "unprognostic (6.88e-3)" "unprognostic (1.40e-1)" "unprognostic (3.02e-2)" "unprognostic (1.24e-2)" "unprognostic (4.81e-2)" "unprognostic (1.81e-1)" "prognostic favourable (8.54e-8)" "unprognostic (3.63e-2)" "unprognostic (1.36e-1)" "unprognostic (1.28e-1)" "prognostic favourable (3.08e-4)" 5.9 2.3 2.0 5.5 3.0 0.1 7.7 3.7 7.2 3.3 19.5 4.2 16.3 22.6 2.9 1.7 2.5 3.6 15.9 17.6 2.3 3.7 8.4 26.4 6.1 2.0 2.5 2.2 2.1 10.3 7.3 5.2 28.5 10.4 3.6 8.2 9.5 4.7 14.7 3.4 2.3 43.2 3.4 3.4 5.2 14.7 28.0 2.1 1.1 26.8 2.5 2.2 3.3 4.2 0.0 2.9 0.0 0.0 0.0 0.0 0.0 5.7 4.3 2.3 11.8 2.4 0.1 36.8 0.5 0.3 2.1 0.4 3.4 14.8 0.0 7.0 0.6 8.1 1.9 1.7 0.6 0.0 3.9 0.0 1.9 19.1 3.1 0.1 7.7 1.2 3.0 0.3 0.9 1.4 4.7 0.0 0.7 2.8 0.2 0.9 6.7 1.2 2.8 0.3 3.1 6.5 2.1 0.6 4.1 7.7 18.5 3.5 2.0 3.1 1.3 0.1 3.7 1.4 0.5 0.0 0.0 0.1 0.7 0.9 30.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.9 0.0 0.0 2.0 3.0 3.7 7.2 2.3 3.7 2.5 2.2 10.4 2.1 MMP16 "C8orf57, DKFZp761D112, MT3-MMP" ENSG00000156103 "Matrix metallopeptidase 16" P51512 8 88032009-88328025 "Cancer-related genes, Enzymes, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins" "Collagen degradation" "Hydrolase, Metalloprotease, Protease" "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 15.9" "Cell line enhanced" "Detected in many" "AN3-CA: 20.0;HUVEC TERT2: 8.7;SH-SY5Y: 11.1;U-138 MG: 9.5;WM-115: 19.5" "Cancer enhanced" "Detected in many" "glioma: 4.8" "Low region specificity" "Detected in all" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA023693 Uncertain Approved Vesicles,Cytosol "Secreted to extracellular matrix" Cytosol Vesicles "HPA023693: AB_1854025" "unprognostic (2.58e-1)" "unprognostic (2.42e-2)" "unprognostic (1.38e-1)" "unprognostic (1.87e-1)" "unprognostic (7.09e-2)" "unprognostic (3.31e-2)" "unprognostic (2.39e-3)" "unprognostic (1.45e-3)" "unprognostic (2.46e-1)" "unprognostic (2.61e-1)" "unprognostic (9.42e-2)" "unprognostic (2.92e-1)" "unprognostic (2.09e-8)" "unprognostic (6.90e-3)" "unprognostic (1.16e-1)" "unprognostic (3.62e-1)" "unprognostic (2.19e-3)" 2.4 1.3 11.0 1.4 6.8 0.5 4.9 8.3 15.9 5.3 2.2 2.9 0.7 0.8 4.9 2.1 1.7 2.1 7.3 2.7 8.7 6.9 0.8 0.9 1.0 1.0 5.5 9.1 3.3 2.1 1.5 1.7 3.0 6.3 3.2 1.7 0.6 1.2 2.4 0.7 1.1 1.3 4.0 4.6 1.5 1.4 1.5 5.5 0.0 3.2 0.7 1.0 2.6 3.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 5.4 20.0 0.7 1.4 0.0 7.3 1.0 2.1 1.2 0.0 0.0 0.0 0.0 3.3 0.0 3.9 0.0 2.5 0.0 2.3 0.0 0.0 0.0 1.7 0.0 0.3 1.0 0.0 3.0 0.9 8.7 0.0 0.7 1.1 0.0 0.0 0.0 1.1 2.0 0.2 0.4 0.0 0.4 0.0 0.1 11.1 0.0 0.0 0.1 0.8 0.0 4.8 9.5 5.4 0.1 2.7 0.0 0.0 0.0 3.8 0.0 19.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 11.0 6.8 8.3 14.1 8.7 6.9 5.5 9.1 6.3 5.5 MMP17 MT4-MMP ENSG00000198598 "Matrix metallopeptidase 17" Q9ULZ9 12 131828393-131851783 "Enzymes, FDA approved drug targets, Predicted intracellular proteins, Predicted secreted proteins" "Hydrolase, Metalloprotease, Protease" "FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 23.3" "Group enriched" "Detected in many" 4 "REH: 16.9;SK-MEL-30: 41.2;WM-115: 60.9" "Cancer enriched" "Detected in many" 10 "melanoma: 29.9" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 9 "classical monocyte: 2.2;intermediate monocyte: 2.1;memory B-cell: 1.4;myeloid DC: 1.2;naive B-cell: 1.7;non-classical monocyte: 2.7" "Group enriched" "Detected in many" 9 "B-cells: 1.7;dendritic cells: 1.2;monocytes: 2.7" "Group enriched" "Detected in many" 5 "amygdala: 51.6;basal ganglia: 52.2;cerebral cortex: 70.8;hippocampal formation: 73.1;hypothalamus: 21.6" "Low region specificity" "Detected in all" "Secreted to extracellular matrix" "unprognostic (9.11e-2)" "unprognostic (1.27e-2)" "unprognostic (1.69e-2)" "unprognostic (3.71e-3)" "unprognostic (5.62e-2)" "unprognostic (1.85e-2)" "unprognostic (8.90e-3)" "unprognostic (2.14e-2)" "unprognostic (2.60e-1)" "unprognostic (2.66e-4)" "unprognostic (7.68e-2)" "unprognostic (5.88e-2)" "unprognostic (9.26e-10)" "unprognostic (1.15e-2)" "unprognostic (2.65e-1)" "unprognostic (1.21e-3)" "unprognostic (2.81e-2)" 4.6 2.0 12.6 3.0 23.3 6.2 2.5 1.4 21.5 5.6 3.0 3.1 0.0 1.4 4.2 0.9 2.1 2.1 7.0 1.1 22.5 10.1 0.5 0.5 1.8 5.5 3.7 7.6 9.0 5.0 3.1 0.7 1.1 2.2 1.6 0.8 1.6 8.5 2.5 1.6 9.7 1.9 1.7 1.6 4.8 1.4 2.9 3.5 0.0 0.8 1.5 1.6 2.8 2.8 1.7 1.2 0.2 2.7 0.1 0.0 1.1 0.1 5.1 0.2 0.4 4.2 1.7 0.0 2.7 6.6 2.5 2.6 0.0 1.5 0.0 2.1 4.1 2.3 2.1 2.5 0.5 0.0 0.3 0.9 1.9 0.0 5.2 0.0 3.7 2.6 0.7 3.6 0.9 3.4 1.0 0.1 3.3 4.6 0.1 3.9 2.3 3.1 16.9 0.0 1.9 0.0 0.0 2.2 0.7 0.3 0.9 41.2 4.8 9.8 2.6 0.7 0.6 3.7 0.3 0.0 0.0 0.0 1.3 0.5 60.9 0.1 2.2 0.0 0.0 2.1 0.0 1.4 0.0 0.0 1.2 1.7 0.0 0.0 0.2 0.1 2.7 0.0 0.0 1.1 12.6 23.3 1.4 17.9 22.5 10.1 3.7 7.6 2.2 3.5 MMP19 "MMP18, RASI-1" ENSG00000123342 "Matrix metallopeptidase 19" Q99542 12 55835433-55842966 "Disease related genes, Enzymes, FDA approved drug targets, Predicted secreted proteins" "Angiogenesis, Collagen degradation, Differentiation" "Developmental protein, Hydrolase, Metalloprotease, Protease" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "adipose tissue: 60.7" "Cell line enriched" "Detected in many" 6 "BEWO: 55.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in single" "Group enriched" "Detected in some" 16 "classical monocyte: 3.2;myeloid DC: 1.0" "Group enriched" "Detected in many" 16 "dendritic cells: 1.0;monocytes: 3.2" "Region enriched" "Detected in single" 6 "olfactory region: 8.8" "Low region specificity" "Detected in all" HPA070804 Approved "Endoplasmic reticulum,Vesicles" "Secreted to extracellular matrix" 800000 "Endoplasmic reticulum, Vesicles" "HPA070804: " "unprognostic (2.61e-1)" "unprognostic (6.56e-2)" "unprognostic (2.28e-2)" "unprognostic (2.42e-1)" "unprognostic (4.77e-3)" "unprognostic (4.77e-3)" "unprognostic (2.01e-2)" "unprognostic (4.03e-2)" "unprognostic (2.85e-2)" "unprognostic (4.30e-2)" "unprognostic (2.37e-1)" "unprognostic (2.09e-1)" "prognostic unfavourable (8.56e-9)" "unprognostic (5.06e-3)" "unprognostic (1.28e-3)" "unprognostic (2.73e-2)" "unprognostic (4.00e-2)" 60.7 1.9 0.2 10.9 0.7 0.0 9.9 0.2 0.5 7.6 3.9 0.4 1.4 0.8 12.7 6.0 3.6 11.8 30.3 4.7 0.6 0.1 4.1 3.0 14.0 15.5 0.5 0.2 7.4 8.1 0.0 0.5 24.5 1.0 2.9 2.8 3.1 2.0 3.5 2.1 2.7 4.1 7.7 0.8 27.4 5.0 2.9 0.2 2.7 3.3 1.8 7.1 5.9 3.5 0.0 1.0 0.1 3.2 0.0 0.0 0.6 0.8 0.0 0.0 0.0 6.2 7.9 55.9 5.9 6.9 2.4 2.8 0.3 0.2 0.0 0.0 8.2 0.0 0.0 1.8 3.3 0.3 0.0 0.0 0.0 0.1 5.1 0.0 0.2 8.2 0.2 1.5 1.5 0.4 0.1 0.0 8.0 0.0 0.0 0.0 0.2 0.0 0.0 1.4 0.0 1.0 2.8 0.0 0.0 0.1 0.0 0.0 0.0 0.1 9.5 1.5 3.3 0.0 0.2 0.0 0.0 0.0 4.3 0.0 0.0 0.0 3.2 0.0 0.0 0.1 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.6 0.2 0.7 0.2 0.5 0.6 0.1 0.5 0.2 1.0 0.2 MMP2 "CLG4, CLG4A, TBE-1" ENSG00000087245 "Matrix metallopeptidase 2" P08253 16 55389700-55506691 "Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Angiogenesis, Collagen degradation" "Hydrolase, Metalloprotease, Protease" "Cancer-related genes, Disease mutation, FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell line enhanced" "Detected in many" "ASC diff: 335.4;ASC TERT1: 97.7;HSkMC: 83.3;U-138 MG: 91.2;U-87 MG: 106.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "HPA001939, CAB002788" Approved Approved Vesicles "Secreted to extracellular matrix" 160000000 Vesicles "CAB002788: , HPA001939: AB_1079395" "unprognostic (7.26e-2)" "unprognostic (1.36e-3)" "unprognostic (1.66e-1)" "unprognostic (2.14e-3)" "unprognostic (5.03e-2)" "unprognostic (1.20e-1)" "unprognostic (1.74e-1)" "unprognostic (9.36e-3)" "unprognostic (4.81e-3)" "unprognostic (3.79e-2)" "unprognostic (4.59e-3)" "unprognostic (6.12e-2)" "unprognostic (1.28e-3)" "unprognostic (1.59e-2)" "unprognostic (8.00e-2)" "unprognostic (8.98e-2)" "unprognostic (4.63e-2)" 197.5 9.0 1.2 13.2 1.6 0.0 136.4 0.8 1.4 74.3 74.4 2.4 36.9 5.6 85.0 123.0 52.3 25.7 115.4 54.0 0.9 0.5 9.4 3.5 38.9 3.9 1.5 1.1 71.0 6.5 0.7 2.2 58.9 2.2 66.8 18.7 36.4 18.6 20.4 68.6 68.2 22.6 57.1 1.8 12.4 20.5 57.0 1.1 1.3 20.6 31.8 9.1 84.1 105.3 0.0 0.0 0.9 0.7 0.0 0.0 0.0 0.3 0.2 11.1 0.1 335.4 97.7 18.2 28.7 65.9 5.8 4.6 0.0 0.1 0.0 23.1 50.5 3.1 0.0 0.2 3.3 0.0 0.0 0.0 0.7 0.1 31.7 0.0 0.8 83.3 0.0 29.8 0.2 37.4 0.0 0.1 19.3 0.0 0.0 0.4 8.8 0.0 0.0 2.6 0.0 0.9 0.4 0.1 20.2 5.3 0.0 0.1 0.0 2.0 52.7 91.2 8.7 17.5 3.7 0.0 0.0 0.1 106.8 1.5 16.6 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.2 0.0 0.0 0.0 1.2 1.6 0.8 1.4 0.9 0.5 1.5 1.1 2.2 1.1 MMP20 ENSG00000137674 "Matrix metallopeptidase 20" O60882 11 102576835-102625332 "Disease related genes, Enzymes, FDA approved drug targets, Predicted secreted proteins" "Hydrolase, Metalloprotease, Protease" "Amelogenesis imperfecta, FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "lymphoid tissue: 1.0;testis: 3.5" "Cell line enhanced" "Detected in some" "CAPAN-2: 2.6;Hep G2: 1.0" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Secreted to extracellular matrix" "unprognostic (4.62e-3)" "unprognostic (2.61e-2)" "unprognostic (1.68e-3)" "unprognostic (1.75e-1)" "unprognostic (2.13e-1)" "unprognostic (3.06e-1)" "unprognostic (2.97e-2)" "unprognostic (6.75e-2)" "unprognostic (9.58e-5)" "unprognostic (6.10e-2)" "unprognostic (2.35e-1)" 0.0 0.0 0.0 0.3 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.5 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.5 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 2.6 0.0 0.5 0.0 0.1 0.0 0.0 0.0 0.3 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 MMP21 ENSG00000154485 "Matrix metallopeptidase 21" Q8N119 10 125766453-125775821 "Disease related genes, Enzymes, FDA approved drug targets, Predicted secreted proteins" "Hydrolase, Metalloprotease, Protease" "FDA approved drug targets, Heterotaxy" "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Tissue enriched" "Detected in some" 13 "epididymis: 37.6" "Cell line enhanced" "Detected in some" "BEWO: 1.0;NB-4: 1.2;U-266/70: 2.1;U-266/84: 1.7" "Not detected" "Not detected" "Cell type enhanced" "Detected in single" "naive B-cell: 1.1" "Low lineage specificity" "Detected in single" "Not detected" "Not detected" "Secreted to extracellular matrix" "unprognostic (1.32e-2)" "unprognostic (1.28e-1)" "unprognostic (8.51e-2)" "unprognostic (2.19e-2)" "unprognostic (4.02e-2)" "unprognostic (2.21e-2)" "unprognostic (4.22e-3)" "unprognostic (1.01e-1)" "unprognostic (2.12e-1)" "unprognostic (1.48e-1)" "unprognostic (2.89e-2)" "unprognostic (3.62e-2)" "unprognostic (9.70e-8)" "unprognostic (1.30e-2)" "unprognostic (7.69e-2)" "unprognostic (7.00e-2)" "unprognostic (2.18e-1)" 0.2 0.1 0.1 0.1 0.4 0.1 0.3 0.7 0.0 0.1 0.2 0.1 0.1 37.6 0.1 0.4 0.2 0.9 0.0 0.4 0.1 1.0 0.1 0.1 0.0 2.8 0.8 0.0 0.3 0.0 0.6 0.1 0.5 0.1 0.0 0.1 0.5 0.1 0.0 0.7 0.2 0.1 0.6 0.1 0.2 0.0 1.1 0.0 0.0 0.1 0.5 0.6 0.0 0.1 0.0 0.0 0.8 0.3 0.0 1.0 0.2 0.1 0.0 0.0 0.0 0.1 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.7 0.7 0.5 0.0 0.0 0.2 0.2 0.1 0.0 0.3 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 1.2 0.1 0.0 0.1 0.0 0.5 0.0 0.0 0.1 0.1 0.2 0.3 0.0 0.0 0.1 0.0 0.0 0.2 0.7 0.0 2.1 1.7 0.0 0.2 0.1 0.0 0.0 0.1 0.0 0.0 0.1 0.1 0.0 0.6 0.0 0.0 1.1 0.0 0.4 0.0 0.5 0.0 0.0 0.0 0.0 MMP23B "MIFR, MIFR-1, MMP22" ENSG00000189409 "Matrix metallopeptidase 23B" O75900 1 1632095-1635263 "Enzymes, FDA approved drug targets, Predicted intracellular proteins" "Hydrolase, Metalloprotease, Protease" "FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "ovary: 51.8" "Cell line enhanced" "Detected in some" "AN3-CA: 3.3;HHSteC: 8.1;NTERA-2: 3.6;PC-3: 3.5;U-266/70: 6.4" "Cancer enhanced" "Detected in single" "ovarian cancer: 0.8" "Not detected" "Not detected" "Cell type enriched" "Detected in some" 5 "plasmacytoid DC: 12.3" "Lineage enriched" "Detected in many" 5 "dendritic cells: 12.3" "Region enriched" "Detected in some" 5 "cerebellum: 8.7" "Not detected" "Not detected" "unprognostic (2.19e-2)" "unprognostic (6.31e-2)" "unprognostic (6.70e-3)" "unprognostic (1.29e-1)" "unprognostic (3.99e-2)" "unprognostic (9.31e-2)" "unprognostic (6.94e-2)" "unprognostic (1.20e-1)" "unprognostic (8.06e-2)" "unprognostic (8.37e-2)" "unprognostic (2.22e-1)" "unprognostic (2.33e-1)" "unprognostic (2.26e-11)" "unprognostic (1.60e-3)" "unprognostic (1.36e-1)" "unprognostic (2.44e-2)" "unprognostic (6.66e-2)" 4.7 2.4 0.3 3.9 0.3 2.1 2.3 0.5 0.4 19.6 3.2 0.1 4.2 3.9 17.3 20.1 4.7 6.4 28.5 14.4 0.2 0.3 3.6 2.3 11.0 3.3 0.1 0.0 51.8 0.7 0.0 3.1 10.5 0.1 32.1 0.2 1.2 1.4 6.3 0.9 2.5 2.7 11.7 0.2 4.1 4.3 13.5 0.0 0.4 1.2 0.9 2.8 13.9 7.0 0.2 12.3 0.1 0.2 2.2 1.8 1.3 1.0 0.0 0.3 3.3 0.0 0.0 1.7 0.0 0.0 0.2 0.0 0.7 0.9 0.2 0.8 0.0 0.1 0.0 0.0 0.0 0.7 2.6 1.0 0.3 2.1 8.1 0.4 0.5 0.2 0.0 0.0 0.0 0.0 0.3 0.3 0.0 0.8 0.0 0.6 3.6 3.5 1.3 0.1 1.6 0.0 0.1 0.6 0.2 0.5 0.0 0.2 0.9 0.0 0.7 0.5 0.3 0.7 0.0 6.4 0.3 1.1 0.1 0.4 0.3 0.0 0.2 0.0 1.8 0.0 1.1 0.0 0.4 1.1 0.0 0.2 0.1 0.9 0.1 2.2 0.1 12.3 0.2 1.3 0.3 0.3 0.5 0.4 0.2 0.3 0.1 0.0 0.1 0.0 MMP24 MT5-MMP ENSG00000125966 "Matrix metallopeptidase 24" Q9Y5R2 20 35226654-35277000 "Enzymes, FDA approved drug targets, Predicted membrane proteins, Predicted secreted proteins" "Cell adhesion" "Hydrolase, Metalloprotease, Protease" "FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 4 "brain: 38.5" "Cell line enhanced" "Detected in some" "A549: 19.6;CACO-2: 29.9;EFO-21: 8.8;RPTEC TERT1: 13.5;U-2 OS: 10.1" "Low cancer specificity" "Detected in many" "Region enriched" "Detected in all" 5 "cerebellum: 38.5" "Low cell type specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low region specificity" "Detected in all" "Region enriched" "Detected in all" 5 "cerebellum: 91.3" "HPA049280, HPA078816" Approved Approved "Nucleoli,Plasma membrane" "Secreted to extracellular matrix" "Nucleoli, Plasma membrane" "HPA049280: , HPA078816: " "unprognostic (1.52e-3)" "unprognostic (1.36e-1)" "unprognostic (1.18e-1)" "unprognostic (4.51e-4)" "unprognostic (2.47e-2)" "unprognostic (7.61e-3)" "unprognostic (1.22e-1)" "unprognostic (4.59e-2)" "unprognostic (2.32e-2)" "unprognostic (8.82e-2)" "unprognostic (9.20e-3)" "unprognostic (7.12e-2)" "prognostic favourable (8.17e-11)" "unprognostic (3.32e-2)" "unprognostic (5.63e-2)" "unprognostic (1.69e-2)" "unprognostic (9.90e-4)" 1.6 1.3 4.0 0.4 7.8 0.6 0.4 38.5 8.9 0.7 0.3 1.3 0.2 2.8 1.6 0.9 0.2 2.8 0.6 1.0 2.7 3.2 8.6 0.9 6.1 0.3 1.8 1.5 0.9 8.0 0.0 3.8 0.6 1.7 2.2 0.1 0.5 0.4 6.0 0.2 1.5 1.7 2.5 0.9 0.6 0.7 0.4 1.4 0.2 0.8 0.2 0.2 0.5 0.2 0.8 0.4 2.2 0.8 0.6 1.2 0.3 0.3 19.6 0.0 0.1 0.1 0.0 0.6 1.1 1.2 2.1 1.1 29.9 5.3 0.0 8.8 1.3 0.3 4.6 0.0 0.9 0.1 0.2 1.0 0.5 0.3 0.0 0.0 0.2 0.1 0.1 0.1 0.0 0.0 0.0 0.3 0.2 0.2 0.1 0.1 7.5 1.3 0.0 0.1 0.0 13.5 0.1 7.8 5.4 1.4 0.5 0.2 0.3 0.1 0.3 4.2 10.1 1.0 0.4 0.1 0.1 0.0 0.9 0.1 0.6 1.0 0.6 0.1 1.0 0.7 1.2 0.6 0.7 0.8 0.4 0.8 0.6 0.6 2.2 0.6 0.8 0.2 0.0 0.3 4.0 7.8 38.5 5.3 2.7 3.2 1.8 1.5 1.7 1.4 MMP25 "MMP20, MMPL1, MT6-MMP" ENSG00000008516 "Matrix metallopeptidase 25" Q9NPA2 16 3046681-3060726 "Enzymes, FDA approved drug targets, Predicted intracellular proteins, Predicted secreted proteins" "Hydrolase, Metalloprotease, Protease" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "blood: 17.6;bone marrow: 25.6;lymphoid tissue: 54.1" "Cell line enriched" "Detected in some" 12 "HMC-1: 49.3" "Cancer enhanced" "Detected in many" "testis cancer: 7.1" "Low region specificity" "Detected in some" "Group enriched" "Detected in some" 6 "basophil: 10.2;eosinophil: 6.0;neutrophil: 17.6" "Lineage enriched" "Detected in many" 10 "granulocytes: 17.6" "Low region specificity" "Detected in single" "Low region specificity" "Detected in all" CAB025177 Uncertain "Secreted to blood" "CAB025177: " "unprognostic (4.51e-3)" "unprognostic (9.28e-3)" "unprognostic (7.57e-2)" "unprognostic (2.95e-3)" "unprognostic (2.26e-1)" "prognostic favourable (1.09e-5)" "unprognostic (1.36e-1)" "unprognostic (7.39e-3)" "unprognostic (7.63e-3)" "unprognostic (2.29e-2)" "unprognostic (1.51e-1)" "unprognostic (2.53e-2)" "unprognostic (2.37e-3)" "unprognostic (1.17e-2)" "unprognostic (8.30e-2)" "unprognostic (4.01e-1)" "unprognostic (2.02e-1)" 4.0 0.3 0.6 12.3 0.4 25.6 0.8 0.5 0.6 0.8 1.1 0.2 0.0 1.0 0.4 0.5 0.8 3.8 1.1 2.8 0.5 0.4 0.7 2.5 10.7 54.1 1.8 0.0 0.6 0.8 0.0 0.5 2.0 1.1 0.6 1.0 1.0 0.9 0.0 2.4 0.6 1.8 0.5 0.4 43.9 1.1 0.7 0.5 4.1 0.7 0.9 4.2 1.5 2.5 0.0 0.3 17.6 0.2 1.7 0.5 0.1 0.2 0.1 0.6 1.5 0.0 0.0 0.2 0.2 0.0 0.0 0.0 0.0 0.3 0.3 0.2 0.0 0.6 0.3 0.0 0.0 3.9 0.8 0.1 0.1 0.0 0.0 0.1 49.3 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.5 0.2 3.0 1.4 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.3 0.0 0.0 0.3 3.5 0.1 0.1 0.4 0.1 0.0 1.2 0.1 0.1 0.0 0.9 0.1 10.2 0.2 6.0 0.3 0.0 0.5 0.0 0.2 0.2 0.0 0.0 0.3 0.2 17.6 1.7 0.0 0.3 0.3 0.1 0.6 0.4 0.5 0.6 0.5 0.4 1.8 0.0 1.1 0.5 MMP26 "endometase, MGC126590, MGC126592" ENSG00000167346 "Matrix metallopeptidase 26" Q9NRE1 11 4704927-4992429 "Enzymes, FDA approved drug targets, Predicted secreted proteins" "Collagen degradation" "Hydrolase, Metalloprotease, Protease" "FDA approved drug targets" "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Tissue enriched" "Detected in some" 13 "endometrium 1: 19.1" "Not detected" "Not detected" "Group enriched" "Detected in some" 20 "endometrial cancer: 8.8;prostate cancer: 2.0" "Not detected" "Not detected" "Not detected" "Not detected" "Secreted to extracellular matrix" "unprognostic (4.21e-3)" "unprognostic (2.63e-1)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 19.1 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 MMP27 ENSG00000137675 "Matrix metallopeptidase 27" Q9H306 11 102691487-102705806 "Enzymes, FDA approved drug targets, Predicted intracellular proteins" "Collagen degradation" "Hydrolase, Metalloprotease, Protease" "FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "breast: 10.4;tongue: 10.0" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Cell type enriched" "Detected in single" 7 "neutrophil: 1.0" "Lineage enriched" "Detected in single" 7 "granulocytes: 1.0" "Not detected" "Not detected" "Not detected" "Not detected" HPA069097 Approved "Intracellular and membrane" "HPA069097: " "unprognostic (3.99e-2)" "unprognostic (2.37e-4)" "unprognostic (1.25e-3)" "unprognostic (1.63e-1)" "unprognostic (4.60e-1)" 3.2 0.0 0.0 0.0 0.5 2.4 10.4 0.0 0.0 1.5 0.8 0.0 0.0 0.3 0.9 4.7 0.8 0.1 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.6 0.0 5.1 0.0 0.8 5.4 2.6 2.0 0.0 0.1 0.4 0.4 0.0 0.9 0.1 10.0 2.2 0.4 0.3 0.0 0.0 1.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 MMP28 "EPILYSIN, MM28, MMP-25, MMP-28" ENSG00000271447 "Matrix metallopeptidase 28" Q9H239 17 35756249-35795707 "Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Hydrolase, Metalloprotease, Protease" "FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell line enriched" "Detected in some" 9 "HaCaT: 28.1" "Low cancer specificity" "Detected in many" "Cell type enhanced" "Detected in many" "naive CD4 T-cell: 7.2;naive CD8 T-cell: 5.9" "Lineage enriched" "Detected in many" 5 "T-cells: 7.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA057288, HPA057890" Approved "Nucleoplasm,Focal adhesion sites" "Secreted to extracellular matrix" Nucleoplasm "Focal adhesion sites" "HPA057288: , HPA057890: " "unprognostic (7.99e-3)" "unprognostic (3.27e-1)" "unprognostic (2.20e-1)" "unprognostic (1.01e-1)" "unprognostic (7.52e-2)" "unprognostic (1.63e-1)" "unprognostic (6.90e-2)" "unprognostic (1.09e-2)" "unprognostic (1.51e-1)" "unprognostic (1.99e-1)" "prognostic unfavourable (6.28e-6)" "unprognostic (9.37e-2)" "unprognostic (1.31e-1)" "unprognostic (8.87e-2)" "unprognostic (1.74e-1)" "unprognostic (1.76e-2)" "unprognostic (3.27e-3)" 8.0 1.6 1.8 2.7 3.7 0.5 4.3 0.0 5.1 1.7 7.3 1.6 1.4 3.0 3.2 4.8 4.3 1.5 12.3 0.5 2.8 0.8 0.2 10.3 0.4 0.0 2.9 0.1 1.3 0.5 0.0 0.7 1.3 2.9 4.1 2.7 0.1 2.1 0.6 4.5 9.3 4.3 0.2 0.6 7.2 13.4 0.2 0.0 4.2 4.4 2.5 5.5 2.2 1.1 1.5 0.1 0.2 1.3 7.2 0.9 0.1 0.5 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 3.0 0.1 0.7 0.0 28.1 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 1.1 0.0 0.0 0.0 2.5 0.0 0.1 0.2 0.0 0.1 0.0 0.2 0.1 0.2 0.0 0.2 0.6 0.0 0.0 0.0 1.6 0.2 0.5 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.1 2.0 1.1 0.4 1.7 0.1 0.9 7.2 5.9 0.1 1.3 0.2 1.5 0.0 0.9 MMP3 "STMY, STMY1" ENSG00000149968 "Matrix metallopeptidase 3" P08254 11 102835801-102843803 "Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Collagen degradation" "Hydrolase, Metalloprotease, Protease" "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 4 "epididymis: 177.5;salivary gland: 73.4" "Group enriched" "Detected in some" 17 "BJ: 98.9;BJ hTERT+: 269.1;fHDF/TERT166: 116.5" "Cancer enhanced" "Detected in many" "head and neck cancer: 59.9" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in many" HPA007875 Uncertain Supported Vesicles "Secreted to extracellular matrix" 170000 Vesicles "HPA007875: AB_1079396" "unprognostic (2.27e-1)" "prognostic unfavourable (9.73e-4)" "unprognostic (1.63e-3)" "unprognostic (5.11e-3)" "unprognostic (3.78e-1)" "unprognostic (5.11e-2)" "unprognostic (5.26e-6)" "unprognostic (3.46e-2)" "unprognostic (7.14e-2)" "unprognostic (2.87e-1)" "prognostic unfavourable (4.09e-4)" "unprognostic (3.26e-2)" "unprognostic (1.22e-15)" "unprognostic (3.17e-1)" "unprognostic (1.55e-1)" "unprognostic (3.43e-2)" "unprognostic (2.34e-1)" 19.1 0.0 0.2 14.4 0.3 0.0 6.9 0.2 0.5 0.2 1.5 0.3 0.2 1.8 28.3 177.5 0.2 0.0 1.4 0.2 0.2 0.0 0.3 0.5 0.4 0.2 0.2 0.2 0.3 0.2 0.0 0.2 0.2 0.2 1.2 1.7 0.2 73.4 1.5 7.3 12.6 0.7 5.9 0.2 0.2 2.8 1.4 0.2 0.2 0.6 1.5 0.9 7.5 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 98.9 269.1 1.7 0.5 0.0 0.0 0.0 0.0 116.5 0.0 0.0 0.0 2.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 7.9 0.3 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 9.2 0.8 0.1 0.0 0.0 0.0 0.0 3.8 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.3 0.2 0.5 0.2 0.0 0.2 0.2 0.2 0.2 MMP7 "MPSL1, PUMP-1" ENSG00000137673 "Matrix metallopeptidase 7" P09237 11 102520508-102530753 "Cancer-related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins" "Collagen degradation" "Hydrolase, Metalloprotease, Protease" "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "gallbladder: 93.0;kidney: 129.5;salivary gland: 79.3" "Cell line enhanced" "Detected in some" "A549: 22.6;CAPAN-2: 126.5;EFO-21: 30.0;RPTEC TERT1: 54.7" "Cancer enhanced" "Detected in all" "pancreatic cancer: 352.1" "Region enriched" "Detected in single" 5 "pons and medulla: 1.3" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in all" "CAB025869, HPA051358" Supported Approved Nucleoplasm,Vesicles "Secreted to extracellular matrix" "Nucleoplasm, Vesicles" "CAB025869: , HPA051358: " "unprognostic (1.06e-3)" "unprognostic (9.51e-2)" "unprognostic (4.15e-2)" "unprognostic (1.38e-1)" "unprognostic (7.70e-3)" "unprognostic (7.28e-2)" "prognostic unfavourable (2.53e-4)" "prognostic unfavourable (3.38e-4)" "unprognostic (3.96e-2)" "unprognostic (5.63e-2)" "unprognostic (6.59e-3)" "unprognostic (1.51e-1)" "unprognostic (6.36e-3)" "unprognostic (1.42e-2)" "unprognostic (5.54e-2)" "unprognostic (1.48e-1)" "unprognostic (1.46e-1)" 6.8 0.2 0.2 1.2 0.2 0.0 28.8 0.2 0.2 5.2 0.2 0.2 2.1 0.0 17.2 12.3 3.3 16.4 93.0 0.2 0.2 0.2 129.5 1.4 5.0 0.9 0.2 0.2 3.9 23.5 0.0 0.7 2.7 1.3 42.0 0.0 0.2 79.3 6.7 0.2 7.8 0.3 0.5 0.2 0.2 0.9 9.4 0.2 1.2 0.3 1.4 4.5 19.9 0.8 0.8 0.0 0.0 0.0 0.0 0.0 0.1 0.0 22.6 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.2 126.5 0.0 30.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 54.7 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.4 0.0 0.2 0.0 0.0 0.0 0.1 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 1.3 0.2 MMP8 CLG1 ENSG00000118113 "Matrix metallopeptidase 8" P22894 11 102711795-102727050 "Cancer-related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Collagen degradation" "Hydrolase, Metalloprotease, Protease" "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 6 "bone marrow: 119.3" "Cell line enriched" "Detected in some" 8 "WM-115: 39.2" "Cancer enriched" "Detected in single" 17 "melanoma: 5.7" "Region enhanced" "Detected in single" "cerebral cortex: 1.7" "Group enriched" "Detected in some" 32 "neutrophil: 1.4;non-classical monocyte: 4.9" "Group enriched" "Detected in many" 32 "granulocytes: 1.4;monocytes: 4.9" "Not detected" "Not detected" "Not detected" "Not detected" "HPA021221, HPA022935" Enhanced "Secreted to extracellular matrix" 83000 "HPA021221: AB_1854043, HPA022935: AB_1854044" "unprognostic (3.03e-1)" "unprognostic (8.49e-5)" "unprognostic (1.08e-2)" "unprognostic (3.95e-3)" "unprognostic (1.80e-1)" "unprognostic (1.01e-2)" "unprognostic (7.68e-3)" "unprognostic (1.27e-1)" "unprognostic (4.92e-2)" "unprognostic (6.64e-3)" "unprognostic (2.45e-6)" "unprognostic (2.33e-4)" "unprognostic (1.33e-1)" "unprognostic (4.97e-1)" "unprognostic (2.30e-2)" 1.9 0.1 0.2 0.2 0.4 119.3 0.3 0.1 1.7 0.1 0.2 0.0 0.0 0.1 0.6 0.1 0.1 0.1 0.1 9.0 0.2 0.3 0.4 0.8 12.6 2.6 0.3 0.0 0.9 0.9 0.1 0.6 1.4 0.2 0.1 0.1 0.1 0.3 0.1 0.6 0.3 0.1 0.2 0.3 18.7 0.2 0.1 0.1 5.2 1.9 0.0 0.1 0.2 7.6 0.0 0.0 1.4 4.9 0.0 0.0 1.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.9 0.0 0.0 0.0 2.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 39.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.4 0.0 4.9 0.0 0.0 1.7 0.2 0.4 0.1 1.7 0.2 0.3 0.3 0.0 0.2 0.1 MMP9 CLG4B ENSG00000100985 "Matrix metallopeptidase 9" P14780 20 46008908-46016561 "Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins" "Collagen degradation" "Hydrolase, Metalloprotease, Protease" "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 6 "adipose tissue: 64.0;blood: 63.2;bone marrow: 89.4;lymphoid tissue: 80.1" "Cell line enriched" "Detected in some" 12 "NB-4: 87.3" "Low cancer specificity" "Detected in all" "Not detected" "Not detected" "Cell type enriched" "Detected in single" 141 "neutrophil: 63.2" "Lineage enriched" "Detected in single" 339 "granulocytes: 63.2" "Not detected" "Not detected" "Not detected" "Not detected" "CAB000348, HPA001238, HPA063909, CAB068199, CAB068200, CAB068201" Enhanced Approved Cytosol "Secreted to blood" 57000000 Cytosol "CAB000348: , CAB068199: , CAB068200: , CAB068201: , HPA001238: AB_1079398, HPA063909: AB_2685150" "unprognostic (4.62e-2)" "unprognostic (1.64e-1)" "unprognostic (2.85e-2)" "prognostic favourable (2.55e-4)" "unprognostic (6.65e-3)" "unprognostic (2.82e-1)" "prognostic unfavourable (7.19e-4)" "unprognostic (1.54e-1)" "unprognostic (8.57e-2)" "unprognostic (3.21e-2)" "unprognostic (4.15e-2)" "unprognostic (1.96e-1)" "prognostic unfavourable (4.05e-5)" "unprognostic (4.65e-1)" "unprognostic (9.85e-3)" "unprognostic (2.48e-2)" "unprognostic (2.17e-3)" 64.0 0.5 0.6 38.6 0.7 89.4 4.3 0.4 0.6 0.8 1.2 0.1 0.0 2.8 0.6 0.2 0.9 1.5 0.6 4.0 0.5 0.6 1.4 2.0 13.3 80.1 0.6 0.0 2.7 1.4 0.0 0.8 2.6 0.5 0.6 0.8 0.5 12.5 0.0 1.3 1.3 4.2 0.3 0.5 53.7 2.5 2.7 0.0 23.6 1.3 2.3 44.5 4.5 2.9 0.0 0.0 63.2 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.8 0.0 7.3 0.0 0.1 0.0 0.3 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.9 0.0 87.3 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.1 0.0 0.0 0.3 0.0 2.6 2.7 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 63.2 0.0 0.0 0.0 0.0 0.0 0.6 0.7 0.4 0.6 0.5 0.6 0.6 0.0 0.5 0.0 MPND FLJ14981 ENSG00000008382 "MPN domain containing" Q8N594 19 4343527-4360086 "Enzymes, Predicted intracellular proteins" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA043274, HPA045475" Approved Approved Nucleoplasm,Nucleoli Nucleoli Nucleoplasm "HPA043274: AB_2678403, HPA045475: " "unprognostic (3.16e-2)" "prognostic favourable (2.99e-4)" "unprognostic (4.85e-2)" "prognostic favourable (6.12e-4)" "unprognostic (8.60e-2)" "unprognostic (5.37e-3)" "unprognostic (3.16e-2)" "prognostic favourable (1.55e-4)" "unprognostic (1.23e-1)" "unprognostic (2.87e-2)" "unprognostic (3.94e-3)" "unprognostic (5.18e-2)" "prognostic favourable (7.04e-4)" "unprognostic (2.22e-3)" "unprognostic (3.22e-1)" "unprognostic (5.44e-2)" "unprognostic (9.04e-2)" 7.7 13.7 18.9 14.1 12.3 11.5 8.0 12.1 21.6 6.5 19.9 6.6 15.7 25.9 8.5 7.8 13.8 8.2 11.8 12.1 14.2 11.3 12.8 25.1 14.3 8.5 12.7 20.0 8.7 20.7 14.5 7.2 7.0 11.9 12.1 13.9 11.5 14.3 9.0 17.4 12.5 20.7 9.3 8.9 10.1 12.5 4.2 6.7 13.5 8.6 8.3 10.1 9.3 11.0 3.1 4.5 10.3 6.0 2.4 5.6 1.9 7.9 6.7 11.1 12.6 6.9 3.3 11.3 3.8 3.7 3.2 4.0 12.9 4.1 7.2 12.2 5.0 8.2 5.0 6.7 1.8 8.1 11.3 5.5 9.4 20.8 5.5 7.3 9.9 5.0 4.8 3.5 3.7 9.8 2.9 18.8 4.0 22.9 17.3 6.3 5.0 9.7 14.3 3.4 10.4 8.2 14.0 12.4 12.7 7.0 10.0 5.3 6.7 9.0 3.7 5.1 5.5 31.3 7.7 15.6 9.6 4.7 5.7 4.1 5.9 10.3 5.1 2.4 2.2 6.0 3.4 1.8 2.6 3.1 4.5 3.1 1.7 1.9 1.2 2.4 2.7 4.5 5.6 1.9 18.9 12.3 12.1 21.6 14.2 11.3 12.7 20.0 11.9 6.7 MYSM1 KIAA1915 ENSG00000162601 "Myb like, SWIRM and MPN domains 1" Q5VVJ2 1 58654739-58700092 "Enzymes, Predicted intracellular proteins" "Transcription, Transcription regulation, Ubl conjugation pathway" "Activator, Chromatin regulator, DNA-binding, Hydrolase, Metalloprotease, Protease" "Disease mutation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA054291, HPA067133" Approved Supported "Nucleoplasm,Plasma membrane" Nucleoplasm "Plasma membrane" "HPA054291: , HPA067133: " "unprognostic (2.95e-3)" "unprognostic (3.64e-2)" "unprognostic (3.20e-2)" "unprognostic (8.68e-2)" "unprognostic (2.08e-2)" "prognostic favourable (5.09e-5)" "unprognostic (8.12e-3)" "unprognostic (9.63e-3)" "unprognostic (5.72e-3)" "unprognostic (3.74e-1)" "unprognostic (2.25e-1)" "unprognostic (4.56e-2)" "unprognostic (2.38e-3)" "unprognostic (4.22e-2)" "unprognostic (1.83e-1)" "unprognostic (8.45e-2)" "unprognostic (1.44e-2)" 13.2 12.3 14.1 14.4 15.7 24.4 17.3 16.9 24.3 14.3 13.7 11.4 11.9 12.5 17.5 14.3 13.5 13.0 9.9 14.1 11.7 8.1 11.0 11.0 12.9 14.3 14.0 13.3 18.1 14.0 16.5 19.2 11.3 18.0 14.4 11.6 9.3 15.5 15.2 23.2 20.4 14.6 13.7 15.2 14.2 11.5 8.3 14.7 11.9 15.5 10.6 12.9 13.3 14.7 1.1 0.7 2.2 2.1 0.2 2.3 0.5 8.2 2.4 6.1 6.5 5.6 7.2 8.8 4.9 5.5 4.9 4.3 4.1 3.6 8.6 1.5 3.7 6.3 6.7 2.9 9.5 5.8 4.6 10.3 1.1 4.5 6.8 15.6 7.9 5.2 4.9 6.4 3.3 1.2 11.0 5.5 5.6 2.8 7.7 13.1 9.7 4.5 6.5 14.8 5.3 4.0 3.2 5.1 4.9 4.2 8.2 11.6 2.5 8.9 4.0 8.8 4.0 6.8 9.4 10.1 4.7 11.4 5.1 11.4 9.6 0.8 0.7 0.5 2.0 1.0 1.4 0.9 1.4 1.6 0.6 1.1 2.3 1.1 2.2 0.2 2.1 0.7 1.4 0.5 14.1 15.7 16.9 24.3 11.7 8.1 14.0 13.3 18.0 14.7 NAALAD2 "GCPIII, NAALADASE2" ENSG00000077616 "N-acetylated alpha-linked acidic dipeptidase 2" Q9Y3Q0 11 90131515-90192894 "Enzymes, Predicted intracellular proteins, Predicted membrane proteins" "Carboxypeptidase, Dipeptidase, Hydrolase, Metalloprotease, Multifunctional enzyme, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "pituitary gland: 44.1" "Group enriched" "Detected in some" 5 "CACO-2: 19.7;SH-SY5Y: 6.6" "Cancer enhanced" "Detected in some" "testis cancer: 1.5" "Low region specificity" "Detected in all" "Cell type enriched" "Detected in single" 6 "non-classical monocyte: 2.4" "Lineage enriched" "Detected in single" 12 "monocytes: 2.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA060820, HPA065419" Approved Approved Nucleoplasm Nucleoplasm "HPA060820: , HPA065419: " "unprognostic (1.68e-1)" "unprognostic (2.66e-3)" "unprognostic (1.49e-1)" "unprognostic (4.52e-3)" "unprognostic (4.73e-3)" "unprognostic (2.97e-1)" "unprognostic (3.82e-3)" "unprognostic (1.77e-2)" "unprognostic (2.44e-1)" "unprognostic (2.30e-1)" "unprognostic (3.30e-2)" "unprognostic (8.00e-2)" "unprognostic (9.97e-4)" "unprognostic (1.52e-2)" "unprognostic (2.54e-1)" "unprognostic (1.63e-2)" "unprognostic (2.93e-1)" 7.7 13.0 5.3 1.8 9.9 1.1 3.1 2.1 9.8 7.8 2.1 3.7 2.8 1.3 10.3 5.4 1.8 4.7 3.7 2.5 5.5 7.4 2.7 1.7 2.8 1.6 6.5 5.0 12.9 2.5 0.9 44.1 8.8 11.9 5.2 2.2 5.8 1.9 3.7 2.1 1.5 2.1 3.5 6.2 4.4 1.8 16.6 7.4 0.0 1.7 1.7 1.2 1.8 3.8 0.0 0.1 0.0 2.4 0.0 0.1 0.1 0.1 0.2 1.9 0.1 0.6 0.1 2.4 0.1 0.1 0.1 0.0 19.7 0.7 0.3 0.2 0.0 0.3 1.4 0.0 0.0 0.0 0.4 1.8 0.4 1.7 0.2 0.1 0.1 2.3 0.0 0.0 0.0 0.4 0.1 0.0 0.0 0.0 0.3 0.3 1.9 0.2 0.3 0.0 0.2 0.0 0.0 0.2 6.6 0.0 0.2 0.0 0.2 0.4 2.5 0.1 1.6 0.4 0.3 1.1 0.3 0.3 0.7 0.3 1.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 2.4 0.1 0.1 0.1 5.3 9.9 2.1 9.8 5.5 7.4 6.5 5.0 11.9 7.4 NAALADL1 ENSG00000168060 "N-acetylated alpha-linked acidic dipeptidase like 1" Q9UQQ1 11 65044818-65058549 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Aminopeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 12 "blood: 49.5;intestine: 123.4" "Cell line enhanced" "Detected in some" "ASC TERT1: 5.3;fHDF/TERT166: 6.7;HHSteC: 18.6;HSkMC: 12.2;SCLC-21H: 9.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Cell type enhanced" "Detected in many" "basophil: 49.5" "Low lineage specificity" "Detected in all" "Not detected" "Not detected" "Low region specificity" "Detected in all" HPA047123 Enhanced Uncertain Cytosol Cytosol "HPA047123: " "unprognostic (2.98e-2)" "unprognostic (2.06e-1)" "unprognostic (1.58e-1)" "unprognostic (8.76e-2)" "unprognostic (1.70e-1)" "unprognostic (1.28e-3)" "unprognostic (1.36e-1)" "unprognostic (1.40e-1)" "unprognostic (1.89e-2)" "unprognostic (1.38e-1)" "unprognostic (3.03e-1)" "unprognostic (2.18e-1)" "unprognostic (1.75e-4)" "unprognostic (2.10e-3)" "unprognostic (3.22e-2)" "unprognostic (1.45e-1)" "unprognostic (4.80e-2)" 4.1 0.9 1.4 3.3 1.6 7.0 4.1 1.9 1.4 6.0 54.3 1.2 2.6 7.8 7.2 1.8 2.7 4.4 3.4 3.5 1.3 0.6 2.3 1.2 3.4 5.2 1.5 1.5 6.2 1.0 0.9 2.0 1.5 1.6 4.6 2.6 3.1 2.3 4.8 2.0 1.6 123.4 4.3 1.4 5.0 2.8 1.8 1.2 1.8 1.8 2.3 2.9 3.1 5.4 8.8 4.9 49.5 6.3 22.2 12.9 7.0 0.0 0.0 0.1 0.2 0.4 5.3 0.9 2.0 0.0 2.5 1.1 0.0 0.0 0.1 0.0 6.7 0.0 0.0 0.1 0.0 0.7 0.3 0.0 0.1 3.0 18.6 0.0 0.0 12.2 0.0 2.4 0.0 3.2 0.0 0.2 0.0 0.2 0.2 0.6 0.0 0.1 0.1 0.0 0.8 0.2 0.0 9.6 0.4 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.3 0.1 0.7 0.0 0.1 0.1 49.5 6.3 10.3 9.5 4.3 4.9 8.0 7.6 4.8 4.9 8.8 8.8 4.9 1.1 22.2 2.5 0.2 12.9 7.0 1.4 1.6 1.9 1.4 1.3 0.6 1.5 1.5 1.6 1.2 NAALADL2 ENSG00000177694 "N-acetylated alpha-linked acidic dipeptidase like 2" Q58DX5 3 174438573-175810552 "Enzymes, Predicted intracellular proteins, Predicted membrane proteins" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "seminal vesicle: 29.3" "Cell line enhanced" "Detected in some" "ASC TERT1: 11.5;BJ hTERT+: 4.1;fHDF/TERT166: 4.8;WM-115: 4.5" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Cell type enhanced" "Detected in single" "plasmacytoid DC: 1.7" "Low lineage specificity" "Detected in single" "Low region specificity" "Detected in many" "HPA012413, HPA017425, CAB025586" Approved Enhanced Nucleoplasm Nucleoplasm "CAB025586: , HPA012413: AB_1854274, HPA017425: AB_1854275" "unprognostic (7.28e-3)" "unprognostic (1.10e-1)" "unprognostic (6.28e-2)" "unprognostic (1.60e-1)" "unprognostic (2.56e-1)" "unprognostic (2.56e-1)" "unprognostic (2.29e-4)" "unprognostic (3.44e-3)" "unprognostic (5.70e-2)" "unprognostic (7.42e-2)" "unprognostic (7.85e-3)" "unprognostic (9.49e-2)" "unprognostic (3.66e-6)" "unprognostic (7.11e-2)" "unprognostic (1.48e-1)" "unprognostic (9.05e-2)" "unprognostic (2.22e-2)" 4.9 2.3 2.2 4.6 3.7 0.8 7.0 1.9 2.7 8.3 8.3 5.4 23.8 2.4 9.7 10.5 2.3 5.0 8.9 5.4 2.5 1.8 7.0 3.7 3.3 1.3 2.3 2.0 5.4 3.9 20.6 3.0 6.4 4.0 9.6 3.3 4.4 17.0 29.3 1.8 3.2 6.6 6.0 3.6 2.6 4.5 1.9 2.9 4.9 3.5 2.6 1.7 8.7 5.0 0.1 1.7 0.2 0.1 0.1 0.8 0.0 0.0 0.0 0.2 0.0 3.5 11.5 0.1 2.3 4.1 0.5 0.7 0.1 1.2 0.0 0.4 4.8 0.0 0.0 0.0 1.7 0.0 0.0 0.2 0.0 0.0 0.6 0.0 0.0 3.2 0.6 0.1 0.0 0.4 0.0 0.1 2.3 0.4 0.2 0.0 0.0 0.0 0.0 0.2 0.1 1.7 0.2 0.0 0.0 0.2 0.2 0.8 3.1 0.1 0.5 2.2 0.1 0.1 0.5 0.0 0.0 0.0 1.5 0.0 4.5 0.2 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.8 0.1 0.0 0.1 0.0 1.7 0.0 0.0 2.2 3.7 1.9 2.7 2.5 1.8 2.3 2.0 4.0 2.9 NAPSA "KAP, Kdap, NAP1, NAPA" ENSG00000131400 "Napsin A aspartic peptidase" O96009 19 50358477-50365830 "Enzymes, Plasma proteins, Predicted secreted proteins" "Aspartyl protease, Hydrolase, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 10 "kidney: 47.5;lung: 153.3" "Cell line enriched" "Detected in some" 24 "U-698: 29.1" "Cancer enriched" "Detected in many" 18 "lung cancer: 249.9" "Not detected" "Not detected" "Cell type enhanced" "Detected in some" "plasmacytoid DC: 10.5" "Group enriched" "Detected in many" 9 "B-cells: 5.1;dendritic cells: 10.5" "Low region specificity" "Detected in single" "Low region specificity" "Detected in all" "CAB009591, HPA045280, HPA047236, HPA047744" Enhanced "Secreted in other tissues" 380000 "CAB009591: , HPA045280: AB_2679283, HPA047236: AB_2679993, HPA047744: AB_2680143" "unprognostic (5.36e-2)" "unprognostic (4.77e-2)" "unprognostic (1.64e-3)" "unprognostic (1.78e-1)" "unprognostic (1.93e-1)" "unprognostic (4.65e-2)" "unprognostic (1.02e-1)" "unprognostic (8.30e-3)" "unprognostic (2.29e-1)" "unprognostic (2.23e-2)" "unprognostic (1.76e-3)" "unprognostic (7.67e-3)" "prognostic favourable (1.21e-4)" "unprognostic (4.08e-4)" "unprognostic (3.29e-1)" "unprognostic (9.83e-3)" "unprognostic (7.26e-5)" 0.1 0.1 0.1 0.2 0.1 0.0 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.0 0.1 5.0 0.1 0.1 0.1 0.1 0.1 0.0 47.5 0.1 153.3 0.1 0.1 0.1 0.1 0.1 0.0 0.1 0.5 0.3 0.1 0.0 0.1 0.1 0.1 0.1 0.1 0.2 0.1 0.1 0.1 0.1 0.2 0.1 0.1 0.3 0.1 0.1 0.1 0.1 5.1 10.5 0.5 0.9 0.5 0.6 1.1 0.1 0.4 0.0 0.2 0.2 0.2 0.1 0.1 0.0 0.0 0.1 0.1 0.4 0.2 0.2 0.1 0.5 0.1 0.0 0.0 0.2 0.6 0.0 0.0 0.0 0.2 0.0 0.2 0.3 1.2 0.1 0.0 0.0 0.3 0.1 0.0 0.6 0.1 0.3 0.2 0.3 0.6 0.0 0.1 0.9 0.0 0.0 0.1 0.3 0.0 0.1 0.1 0.3 0.1 0.0 0.1 0.8 0.0 0.2 0.4 29.1 0.0 0.1 0.0 0.0 0.4 0.0 0.1 0.9 0.0 5.1 0.2 0.4 3.0 1.9 0.6 0.5 0.5 0.5 0.9 10.5 0.0 1.1 0.1 0.1 0.1 0.1 0.1 0.0 0.1 0.1 0.3 0.1 NLN "AGTBP, KIAA1226" ENSG00000123213 Neurolysin Q9BYT8 5 65722196-65871725 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 5 "classical monocyte: 4.7;intermediate monocyte: 5.9;myeloid DC: 4.1;non-classical monocyte: 4.1" "Group enriched" "Detected in many" 5 "dendritic cells: 4.1;monocytes: 5.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA031862 Approved Approved Mitochondria 53000 Mitochondria "HPA031862: AB_10600827" "unprognostic (5.91e-3)" "unprognostic (4.52e-2)" "unprognostic (1.34e-3)" "unprognostic (4.37e-2)" "unprognostic (3.85e-1)" "unprognostic (1.45e-2)" "unprognostic (7.29e-3)" "unprognostic (3.24e-2)" "unprognostic (3.19e-1)" "unprognostic (3.58e-1)" "prognostic unfavourable (7.51e-4)" "unprognostic (1.27e-1)" "prognostic favourable (5.58e-7)" "unprognostic (1.52e-2)" "unprognostic (1.98e-1)" "unprognostic (1.29e-1)" "unprognostic (6.18e-3)" 4.5 2.4 7.6 4.7 10.5 2.9 7.3 2.8 11.9 4.1 6.8 5.8 1.0 2.4 5.8 5.0 5.2 3.3 2.7 5.1 7.2 7.6 7.5 18.9 3.4 5.1 8.7 8.5 4.0 11.0 3.6 2.4 4.9 9.8 5.4 6.5 2.0 4.3 2.6 15.0 5.7 5.3 5.5 10.9 5.8 7.5 2.4 6.2 1.8 5.5 7.9 4.0 4.3 3.3 0.9 4.1 0.6 5.9 0.9 0.7 1.8 9.2 8.9 5.3 8.7 6.6 11.4 10.6 9.3 3.9 5.5 6.0 5.0 5.5 13.2 11.8 11.2 7.4 6.8 14.4 9.6 3.9 4.6 3.6 6.6 12.8 5.7 8.3 2.2 8.7 7.9 7.6 9.1 15.5 7.8 2.8 11.8 7.1 5.7 7.5 16.1 2.5 6.7 11.2 20.8 9.0 4.1 16.3 8.5 7.5 7.8 7.7 9.3 9.9 8.9 3.7 4.4 5.3 7.0 2.4 4.8 5.8 5.6 16.3 5.5 0.2 4.7 0.2 0.2 5.9 0.3 0.9 0.4 0.3 4.1 0.9 0.7 0.5 0.6 0.9 4.1 0.2 0.1 1.8 7.6 10.5 2.8 11.9 7.2 7.6 8.7 8.5 9.8 6.2 NPEPL1 "bA261P9.2, FLJ11583" ENSG00000215440 "Aminopeptidase like 1" Q8NDH3 20 58689131-58719238 "Enzymes, Predicted intracellular proteins" "Aminopeptidase, Hydrolase, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell line enhanced" "Detected in many" "MCF7: 43.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 4 "basophil: 12.2;classical monocyte: 13.4;eosinophil: 4.9;intermediate monocyte: 8.9;myeloid DC: 8.2;neutrophil: 9.6;non-classical monocyte: 11.9" "Group enriched" "Detected in all" 5 "dendritic cells: 8.2;granulocytes: 12.2;monocytes: 13.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" "CAB004986, CAB017025, HPA036356" Approved Approved Nucleoplasm 16000 Nucleoplasm "CAB004986: AB_426073, CAB017025: , HPA036356: " "unprognostic (1.68e-1)" "unprognostic (5.87e-3)" "unprognostic (8.28e-2)" "unprognostic (2.78e-1)" "unprognostic (5.42e-2)" "unprognostic (1.47e-3)" "unprognostic (2.86e-3)" "unprognostic (3.11e-2)" "unprognostic (4.14e-1)" "unprognostic (1.08e-2)" "unprognostic (1.62e-3)" "unprognostic (3.78e-2)" "prognostic unfavourable (1.87e-9)" "unprognostic (7.97e-2)" "unprognostic (1.64e-1)" "unprognostic (2.21e-1)" "prognostic favourable (5.73e-4)" 17.2 10.3 9.9 9.7 15.3 15.8 25.0 24.2 10.1 9.6 14.9 10.2 17.2 14.4 11.9 23.5 17.9 12.5 24.5 19.4 10.1 8.6 16.7 11.9 14.5 12.6 12.9 7.2 12.5 15.6 13.6 11.4 11.2 13.1 15.0 4.5 15.7 19.1 17.2 51.8 15.2 13.7 25.8 10.0 16.5 12.8 13.0 9.0 5.6 16.5 20.4 11.8 15.3 20.4 1.0 8.2 12.2 13.4 2.0 2.3 4.1 9.1 12.9 2.3 1.9 5.2 9.6 0.7 3.4 0.3 11.6 6.5 7.4 7.0 0.4 19.2 6.6 9.9 3.2 4.4 1.1 8.1 2.8 3.0 9.9 3.2 13.2 3.3 5.5 9.4 13.7 4.0 0.0 9.7 0.4 1.4 4.5 43.0 1.3 8.7 3.4 13.4 2.6 1.1 5.0 4.7 5.9 4.3 1.3 9.4 2.6 17.3 10.0 6.3 10.2 2.9 2.3 5.8 1.8 4.5 1.6 0.3 4.2 6.3 1.1 12.2 13.4 4.9 1.9 8.9 2.3 1.0 1.1 1.3 8.2 0.7 0.7 1.3 9.6 2.0 11.9 0.4 2.3 4.1 9.9 15.3 24.2 10.1 10.1 8.6 12.9 7.2 13.1 9.0 NPEPPS "MP100, PSA" ENSG00000141279 "Aminopeptidase puromycin sensitive" P55786 17 47522942-47623276 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Aminopeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell line enhanced" "Detected in all" "T-47d: 80.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA021453, HPA045649" Uncertain Supported Cytosol 2100000 Cytosol "HPA021453: , HPA045649: " "unprognostic (1.63e-1)" "unprognostic (3.15e-2)" "prognostic favourable (3.39e-5)" "unprognostic (2.66e-2)" "unprognostic (1.53e-1)" "unprognostic (5.92e-2)" "prognostic unfavourable (3.67e-5)" "unprognostic (3.84e-2)" "unprognostic (1.22e-1)" "unprognostic (1.77e-1)" "unprognostic (3.85e-2)" "unprognostic (3.63e-2)" "unprognostic (1.93e-1)" "unprognostic (8.55e-2)" "unprognostic (1.52e-1)" "unprognostic (1.23e-2)" "unprognostic (1.07e-1)" 16.0 26.0 27.2 15.9 27.7 11.1 56.1 36.5 33.8 17.1 17.7 9.8 14.6 14.6 16.9 17.1 47.7 17.2 16.3 22.2 24.0 15.6 18.8 11.1 30.3 24.1 16.0 29.7 20.8 16.8 21.2 15.3 17.6 27.2 18.6 20.0 13.3 21.8 16.5 52.3 29.6 17.3 20.4 22.8 15.7 16.2 15.3 16.1 7.0 14.5 14.8 18.1 19.0 30.5 6.9 9.0 23.2 8.6 9.3 9.2 5.4 32.6 21.5 21.7 15.2 25.1 25.3 45.8 14.4 18.7 21.9 21.3 13.8 37.6 19.5 22.4 21.0 19.9 23.8 13.3 34.1 8.7 20.6 23.5 22.2 16.1 14.5 13.2 15.2 19.3 13.1 15.9 8.3 22.5 19.8 11.4 31.0 8.8 17.5 11.8 13.3 19.6 14.2 30.5 17.2 27.3 24.0 17.4 15.0 18.6 10.8 12.8 80.9 9.2 28.7 14.6 10.5 21.8 10.1 23.3 22.4 11.9 20.7 7.0 9.6 10.2 8.6 10.7 9.1 6.6 9.2 6.8 7.3 8.5 8.7 6.9 6.5 7.6 23.2 9.3 6.8 9.0 8.4 5.4 27.2 27.7 36.5 33.8 24.0 15.6 16.0 29.7 27.2 16.1 NRDC "hNRD1, hNRD2, NRD1" ENSG00000078618 "Nardilysin convertase" O43847 1 51789191-51878937 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 96.4" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA053661 Approved Nucleoplasm Nucleoplasm "HPA053661: " "unprognostic (1.22e-1)" "unprognostic (6.52e-2)" "unprognostic (2.14e-2)" "unprognostic (5.62e-2)" "unprognostic (2.61e-1)" "unprognostic (3.25e-2)" "prognostic unfavourable (5.49e-6)" "unprognostic (1.42e-1)" "unprognostic (4.17e-2)" "unprognostic (1.67e-1)" "unprognostic (5.86e-2)" "unprognostic (1.00e-1)" "prognostic unfavourable (2.12e-9)" "unprognostic (2.75e-1)" "unprognostic (2.35e-2)" "unprognostic (9.54e-2)" "unprognostic (5.53e-3)" 16.4 15.9 13.4 15.8 17.5 14.5 11.7 14.7 16.9 12.2 13.7 11.0 9.9 11.2 11.8 12.1 14.4 10.9 10.9 25.7 13.1 13.3 12.4 28.5 12.0 13.6 16.2 10.6 11.7 15.9 19.3 21.4 14.2 15.7 13.8 12.1 9.8 11.9 11.3 96.4 19.1 10.3 13.3 14.0 13.6 11.9 32.3 14.5 19.4 11.7 21.5 15.1 13.0 16.0 13.8 18.5 36.3 19.1 15.8 15.1 16.2 47.6 26.8 26.9 38.7 28.3 43.9 31.4 48.1 41.6 35.0 37.2 18.8 18.8 31.4 25.8 36.2 27.8 39.6 37.3 44.4 37.2 19.5 37.5 36.5 16.3 29.1 32.7 28.6 34.9 28.6 51.1 47.5 36.4 49.4 21.1 43.8 17.4 29.6 11.3 47.8 28.9 29.0 32.2 34.6 25.9 27.7 25.9 19.5 43.9 35.3 26.0 23.6 39.9 30.2 30.8 28.6 33.5 40.9 31.5 47.6 29.4 36.4 41.3 35.3 19.3 18.1 26.0 13.7 19.1 13.7 13.8 12.7 15.1 18.5 9.3 12.5 13.4 36.3 15.8 14.5 15.0 14.4 16.2 13.4 17.5 14.7 16.9 13.1 13.3 16.2 10.6 15.7 14.5 OMA1 "FLJ33782, MPRP-1, YKR087C, ZMPOMA1" ENSG00000162600 "OMA1 zinc metallopeptidase" Q96E52 1 58415384-58546802 "Cancer-related genes, Enzymes, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Metalloprotease, Protease" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA055120 Approved Approved Nucleoplasm,Mitochondria "Nucleoplasm, Mitochondria" "HPA055120: " "prognostic favourable (1.63e-4)" "unprognostic (2.67e-2)" "prognostic favourable (7.70e-4)" "unprognostic (1.60e-3)" "unprognostic (1.61e-1)" "unprognostic (9.57e-2)" "unprognostic (3.94e-3)" "prognostic favourable (8.52e-4)" "unprognostic (8.22e-3)" "unprognostic (6.91e-2)" "unprognostic (4.10e-2)" "unprognostic (1.40e-1)" "unprognostic (9.54e-3)" "unprognostic (2.52e-2)" "unprognostic (3.93e-2)" "unprognostic (1.74e-2)" "unprognostic (5.24e-3)" 10.2 22.4 13.8 21.5 18.1 9.2 15.8 10.6 14.6 14.5 16.4 14.1 20.1 12.1 15.4 15.1 17.1 15.9 12.1 15.8 12.6 10.0 23.0 23.8 19.1 17.9 16.7 9.6 15.0 18.2 15.7 20.9 8.9 13.0 17.8 16.1 11.3 20.6 22.7 20.9 10.2 16.1 24.2 18.2 17.2 13.9 6.9 19.4 18.4 18.3 14.5 16.4 17.0 20.6 22.5 9.5 18.6 19.5 18.6 22.8 10.2 13.5 5.7 3.8 3.5 19.2 18.0 10.9 5.6 6.1 4.9 6.2 1.6 8.2 30.7 11.9 5.8 13.9 13.4 13.7 5.9 23.5 7.5 9.6 4.4 6.6 9.6 23.3 6.7 17.0 15.3 4.8 10.0 4.3 18.0 9.2 13.4 8.3 7.9 8.3 5.6 12.4 9.9 12.5 12.8 10.7 9.1 4.0 1.9 11.4 18.9 15.8 8.5 9.0 2.5 2.5 5.1 12.6 5.8 7.5 9.8 20.2 7.8 18.3 6.2 10.8 9.2 18.6 12.8 14.5 16.5 22.5 15.7 15.0 9.5 21.4 22.8 20.8 10.6 18.6 19.5 5.0 13.9 10.2 13.8 18.1 10.6 14.6 12.6 10.0 16.7 9.6 13.0 19.4 OTUB1 "FLJ20113, FLJ40710" ENSG00000167770 "OTU deubiquitinase, ubiquitin aldehyde binding 1" Q96FW1 11 63985853-64001811 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Adaptive immunity, DNA damage, DNA repair, Immunity, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA039176, CAB072836" Approved Supported Approved Nucleoplasm,Cytosol 630000 "Nucleoplasm, Cytosol" "CAB072836: , HPA039176: AB_10674980" "unprognostic (2.50e-1)" "unprognostic (5.70e-3)" "unprognostic (3.93e-2)" "unprognostic (1.63e-1)" "unprognostic (2.78e-1)" "prognostic unfavourable (3.05e-4)" "unprognostic (1.85e-3)" "unprognostic (1.34e-2)" "unprognostic (2.45e-1)" "unprognostic (1.27e-2)" "unprognostic (3.04e-1)" "unprognostic (1.34e-1)" "unprognostic (1.33e-3)" "unprognostic (6.76e-2)" "unprognostic (1.42e-1)" "unprognostic (4.84e-2)" "unprognostic (1.82e-1)" 19.8 24.7 41.9 24.1 61.6 32.6 20.8 41.8 101.9 24.3 25.0 31.9 22.3 24.7 21.9 23.6 37.8 34.5 21.6 31.6 46.9 37.8 27.2 27.6 23.0 31.9 33.1 45.4 23.4 23.0 26.0 21.6 30.7 60.4 23.8 24.1 24.2 30.4 27.7 26.7 36.9 26.0 23.1 26.7 25.7 23.9 22.1 21.2 27.8 29.9 24.5 32.8 27.1 22.9 46.0 60.8 56.1 71.3 44.8 64.5 78.2 30.5 55.2 30.5 26.9 20.6 22.8 23.4 18.4 27.4 41.0 30.3 37.0 29.3 16.3 35.0 29.5 38.2 39.3 45.8 25.5 18.8 30.5 27.1 33.1 46.8 28.9 26.9 29.8 24.2 29.8 31.3 20.0 38.6 18.9 18.5 27.5 62.8 29.3 35.6 35.7 26.3 24.1 11.9 27.8 42.6 44.7 23.1 33.3 20.8 32.0 33.6 49.6 23.8 27.9 21.9 21.3 29.3 24.1 21.8 13.7 23.3 28.3 17.5 20.9 55.1 56.3 54.3 53.1 71.3 41.4 46.0 49.1 48.6 60.8 41.9 38.4 42.6 56.1 44.8 60.9 42.1 64.5 78.2 41.9 61.6 41.8 101.9 46.9 37.8 33.1 45.4 60.4 21.2 OTUB2 "C14orf137, FLJ21916, MGC3102" ENSG00000089723 "OTU deubiquitinase, ubiquitin aldehyde binding 2" Q96DC9 14 94026329-94048930 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "testis: 34.5" "Cell line enhanced" "Detected in many" "Karpas-707: 18.2;RPTEC TERT1: 11.4" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Group enriched" "Detected in some" 5 "classical monocyte: 2.1;intermediate monocyte: 2.5;myeloid DC: 3.3;non-classical monocyte: 1.9" "Group enriched" "Detected in many" 5 "dendritic cells: 3.3;monocytes: 2.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA002329 Enhanced "HPA002329: AB_1079537" "unprognostic (6.80e-3)" "unprognostic (1.39e-3)" "unprognostic (3.68e-3)" "unprognostic (4.82e-3)" "unprognostic (1.66e-1)" "unprognostic (2.20e-1)" "unprognostic (2.30e-3)" "unprognostic (1.18e-2)" "unprognostic (2.55e-1)" "unprognostic (3.09e-3)" "unprognostic (2.80e-2)" "unprognostic (1.16e-2)" "unprognostic (6.25e-3)" "unprognostic (1.15e-1)" "unprognostic (2.06e-2)" "unprognostic (1.02e-4)" "unprognostic (3.16e-1)" 2.3 1.3 2.6 0.5 3.3 0.4 1.7 1.0 5.3 2.9 1.0 0.8 1.9 0.7 1.7 1.4 5.2 1.2 0.8 0.4 3.3 1.1 1.7 1.5 0.7 0.6 0.8 1.3 1.6 1.7 4.6 1.0 6.2 1.4 1.2 1.6 0.8 1.9 0.5 0.3 9.5 0.7 0.6 1.0 0.6 1.0 34.5 0.5 0.0 0.6 1.0 2.6 1.7 2.0 0.2 3.3 0.2 2.5 0.0 0.5 0.9 1.3 3.6 2.4 2.3 1.0 0.8 2.8 0.5 0.3 1.5 2.1 0.8 5.9 0.3 2.3 0.6 0.3 3.2 1.7 1.2 0.8 1.4 0.1 0.4 3.7 1.3 0.0 0.6 0.6 2.2 0.5 0.9 1.6 0.1 18.2 0.7 1.2 0.1 0.4 0.7 3.1 0.1 0.2 1.0 11.4 1.7 1.8 1.3 0.7 0.8 1.9 6.4 0.8 1.6 1.0 2.9 0.7 1.0 3.0 2.1 0.0 1.8 0.9 1.4 0.0 2.1 0.0 0.3 2.5 0.0 0.2 0.4 0.5 3.3 0.0 0.2 0.0 0.2 0.0 1.9 0.1 0.2 0.9 2.6 3.3 1.0 5.3 3.3 1.1 0.8 1.3 1.4 0.5 OTUD5 "DKFZp761A052, DUBA" ENSG00000068308 "OTU deubiquitinase 5" Q96G74 X 48922028-48958386 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell line enriched" "Detected in all" 4 "U-266/70: 182.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA017375 Approved Approved "Nucleoplasm,Nucleoli fibrillar center,Cytosol" Cytosol "Nucleoplasm, Nucleoli fibrillar center" "HPA017375: AB_1854844" "unprognostic (9.73e-2)" "prognostic favourable (9.57e-4)" "unprognostic (2.67e-2)" "unprognostic (7.25e-2)" "unprognostic (1.08e-1)" "unprognostic (6.65e-2)" "unprognostic (2.33e-3)" "prognostic favourable (1.48e-4)" "unprognostic (1.11e-1)" "unprognostic (1.14e-1)" "prognostic favourable (8.20e-4)" "unprognostic (1.32e-1)" "unprognostic (3.60e-1)" "unprognostic (1.19e-1)" "unprognostic (1.10e-1)" "unprognostic (4.88e-2)" "unprognostic (5.05e-3)" 23.5 27.5 32.4 26.8 40.9 38.4 21.9 35.0 52.4 21.3 22.9 28.2 23.4 30.5 25.5 26.8 20.5 25.1 20.9 16.6 29.8 31.3 22.6 24.5 25.2 30.8 25.4 29.8 30.0 25.4 29.6 26.8 23.1 29.4 24.0 17.8 20.4 26.9 27.4 24.4 24.5 29.1 27.1 21.4 34.5 22.3 12.7 24.0 34.8 24.5 14.4 27.2 22.1 22.7 7.8 6.3 8.6 5.1 18.6 7.5 3.5 6.1 9.3 4.3 10.7 7.4 6.6 5.0 5.4 6.3 6.8 7.4 4.6 6.8 6.9 3.5 6.8 7.5 6.5 5.4 6.4 8.0 7.9 5.2 9.4 5.3 6.2 4.9 5.8 7.3 5.1 7.1 4.8 5.4 6.5 10.9 4.8 6.1 7.7 10.7 7.8 7.3 6.1 6.4 8.9 4.8 5.5 4.2 7.4 7.1 4.6 7.1 6.1 4.5 7.6 4.4 5.6 11.7 4.4 182.8 45.6 6.6 6.9 6.9 3.0 5.2 3.4 7.0 7.0 5.1 5.8 7.8 5.5 6.0 4.8 6.0 5.2 7.5 8.6 18.6 4.7 6.3 7.0 3.5 32.4 40.9 35.0 52.4 29.8 31.3 25.4 29.8 29.4 24.0 OTUD7A "C15orf16, CEZANNE2, OTUD7" ENSG00000169918 "OTU deubiquitinase 7A" Q8TE49 15 31475398-31870789 "Cancer-related genes, Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 20.4" "Low cell line specificity" "Detected in many" "Low cancer specificity" "Detected in single" "Low region specificity" "Detected in all" "Cell type enhanced" "Detected in some" "plasmacytoid DC: 3.2" "Low lineage specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA044554 Uncertain Approved Nucleoli,Cytosol "Nucleoli, Cytosol" "HPA044554: AB_10794895" "unprognostic (3.61e-2)" "unprognostic (1.35e-3)" "unprognostic (1.39e-1)" "unprognostic (1.25e-3)" "unprognostic (1.29e-1)" "unprognostic (1.03e-4)" "unprognostic (1.50e-1)" "unprognostic (1.21e-1)" "unprognostic (1.38e-1)" "unprognostic (1.67e-1)" "unprognostic (3.24e-3)" "unprognostic (1.34e-1)" "unprognostic (1.79e-11)" "unprognostic (6.78e-2)" "unprognostic (2.76e-1)" "unprognostic (8.27e-2)" "unprognostic (1.79e-1)" 2.6 2.0 12.4 1.7 13.9 5.9 1.5 13.2 17.0 1.8 3.4 16.0 0.0 1.5 1.9 1.9 1.9 2.0 2.3 2.1 10.0 4.6 2.3 1.0 1.5 3.5 20.4 7.1 2.0 2.5 4.6 1.7 0.9 10.5 1.2 3.1 0.7 1.6 2.0 1.8 3.2 2.1 2.9 9.1 2.2 2.3 8.2 17.4 0.0 2.3 0.0 2.4 1.9 1.3 0.1 3.2 0.3 1.4 0.1 0.7 0.4 3.6 4.1 4.5 6.0 0.4 1.3 3.2 2.5 1.3 3.9 1.9 2.5 3.2 2.9 2.2 0.9 4.6 4.8 2.0 3.2 5.9 6.6 3.7 8.3 2.0 0.3 4.0 5.7 0.0 0.2 3.8 4.3 3.5 6.0 5.4 1.8 2.9 3.1 3.9 2.0 2.0 5.6 3.0 1.4 1.6 3.9 10.9 6.0 3.4 3.0 1.0 2.5 4.3 2.3 5.3 5.2 3.0 6.2 3.3 2.4 3.0 2.9 5.8 4.5 0.0 0.4 0.3 0.6 0.5 0.3 0.0 0.3 0.7 0.2 0.1 0.2 0.2 0.0 0.1 1.4 3.2 0.0 0.4 12.4 13.9 13.2 13.8 10.0 4.6 20.4 7.1 10.5 17.4 OTUD7B "CEZANNE, ZA20D1" ENSG00000264522 "OTU deubiquitinase 7B" Q6GQQ9 1 149937812-150010676 "Enzymes, Predicted intracellular proteins" "Adaptive immunity, Immunity, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Cell type enhanced" "Detected in many" "basophil: 4.7" "Group enriched" "Detected in many" 4 "granulocytes: 4.7;NK-cells: 1.4;T-cells: 2.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA027045 Supported Approved Nucleoplasm,Microtubules "Nucleoplasm, Microtubules" "HPA027045: AB_1854847" "unprognostic (2.17e-2)" "unprognostic (2.93e-2)" "unprognostic (1.90e-1)" "prognostic favourable (7.47e-4)" "unprognostic (1.51e-1)" "unprognostic (1.05e-1)" "unprognostic (1.23e-3)" "unprognostic (1.46e-2)" "prognostic favourable (5.09e-5)" "unprognostic (4.90e-2)" "unprognostic (7.72e-2)" "unprognostic (8.94e-2)" "unprognostic (3.37e-2)" "unprognostic (1.67e-2)" "unprognostic (1.18e-1)" "unprognostic (4.52e-2)" "unprognostic (1.58e-2)" 8.8 6.2 5.8 2.6 12.3 0.3 6.2 8.5 8.9 8.6 6.3 20.6 4.0 4.6 8.5 4.1 6.1 7.6 4.3 5.3 6.0 4.5 8.6 5.6 0.9 12.7 5.1 9.2 4.5 12.5 4.3 5.3 11.6 5.3 5.6 7.4 5.4 6.3 13.2 4.3 5.1 8.9 8.5 2.3 5.2 9.6 12.5 0.0 8.3 2.3 2.1 6.3 7.1 0.6 0.6 4.7 0.3 1.4 2.3 0.2 11.4 9.2 6.5 10.8 8.6 8.0 6.1 8.1 11.9 9.7 6.7 6.8 9.3 0.1 5.3 14.6 9.2 9.1 8.9 10.3 11.0 4.7 4.4 12.8 4.5 9.2 5.0 4.8 8.8 6.9 16.5 14.5 7.9 12.0 12.5 7.0 11.7 0.8 1.4 8.2 9.0 1.2 8.9 2.9 3.8 15.7 4.2 7.9 14.2 10.5 12.8 8.7 2.6 9.5 10.1 9.4 6.8 9.4 13.4 12.9 1.3 9.0 1.5 16.5 4.7 0.3 1.3 2.3 0.2 1.7 0.6 1.0 1.4 0.1 0.6 0.9 1.0 1.2 1.4 0.3 0.6 0.6 0.2 OTULIN "FAM105B, FLJ34884" ENSG00000154124 "OTU deubiquitinase with linear linkage specificity" Q96BN8 5 14664664-14699711 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" "Angiogenesis, Immunity, Innate immunity, Ubl conjugation pathway, Wnt signaling pathway" "Hydrolase, Protease, Thiol protease" "Disease mutation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA051074 Uncertain Approved "Plasma membrane,Mitochondria" Mitochondria "Plasma membrane" "HPA051074: " "unprognostic (4.81e-3)" "unprognostic (1.11e-1)" "unprognostic (4.00e-2)" "unprognostic (1.19e-2)" "unprognostic (7.48e-2)" "unprognostic (1.91e-2)" "unprognostic (7.94e-3)" "unprognostic (1.43e-1)" "unprognostic (2.48e-2)" "unprognostic (9.55e-2)" "unprognostic (1.02e-1)" "unprognostic (7.13e-2)" "prognostic unfavourable (2.59e-7)" "unprognostic (2.92e-2)" "unprognostic (2.28e-2)" "unprognostic (1.60e-1)" "unprognostic (5.02e-2)" 10.0 7.4 5.9 22.6 7.8 32.3 8.4 7.2 6.6 8.2 9.3 8.3 8.9 10.7 9.5 7.7 13.8 6.1 10.8 15.5 6.7 4.9 8.5 19.5 11.1 16.0 9.6 2.8 9.1 12.2 7.5 9.8 11.8 7.0 11.1 7.0 7.7 10.6 10.8 16.5 18.1 11.7 8.1 10.5 12.5 7.1 11.5 7.4 15.0 7.8 9.7 19.3 8.5 15.8 3.4 2.9 3.1 3.0 1.0 4.6 0.9 6.3 7.4 7.4 8.4 6.9 7.2 8.2 6.4 4.5 9.1 6.9 9.9 4.7 11.4 12.6 4.1 7.2 9.2 8.4 6.3 19.7 7.6 8.2 23.5 5.3 5.9 7.8 14.1 4.1 10.3 7.5 6.4 7.7 8.1 18.3 6.5 3.9 7.7 6.8 4.5 7.8 11.9 6.7 4.6 6.0 6.6 3.4 5.5 22.8 5.1 4.9 5.6 9.0 7.1 11.9 13.4 8.9 8.4 8.3 12.5 13.0 6.8 14.9 6.1 0.4 2.0 3.1 1.0 2.2 3.0 0.9 2.5 3.4 2.9 3.4 1.8 3.9 2.2 1.0 3.0 2.5 4.6 0.9 5.9 7.8 7.2 6.6 6.7 4.9 9.6 2.8 7.0 7.4 OVCH1 OVCH ENSG00000187950 "Ovochymase 1" Q7RTY7 12 29412474-29497686 "Enzymes, Predicted intracellular proteins, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "lung: 9.5;testis: 4.6" "Cell line enriched" "Detected in some" 5 "Daudi: 10.7" "Not detected" "Not detected" "Cell type enhanced" "Detected in single" "neutrophil: 1.3" "Low lineage specificity" "Detected in single" "Low region specificity" "Detected in many" "Secreted in female reproductive system" "unprognostic (3.32e-1)" "unprognostic (2.20e-1)" "unprognostic (2.03e-1)" "unprognostic (1.56e-5)" "unprognostic (1.68e-1)" "unprognostic (1.58e-1)" "unprognostic (4.41e-2)" "unprognostic (1.83e-1)" "unprognostic (2.25e-2)" "unprognostic (5.46e-2)" "unprognostic (1.36e-1)" "unprognostic (5.48e-2)" "unprognostic (5.59e-3)" "unprognostic (1.04e-1)" "unprognostic (2.14e-1)" "unprognostic (3.52e-2)" "unprognostic (2.06e-1)" 0.6 0.4 0.0 0.4 0.3 0.1 0.5 0.0 0.1 0.4 0.2 0.0 0.2 0.0 0.1 0.2 0.4 0.2 0.1 0.2 0.2 0.3 9.5 0.2 0.1 0.3 0.0 0.0 0.6 0.0 0.1 0.3 0.0 0.0 0.3 0.5 0.1 0.0 0.2 1.9 0.2 4.6 2.1 0.0 0.1 0.2 0.5 0.2 1.3 0.5 0.0 0.6 0.3 0.0 0.0 0.6 0.0 0.7 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 10.7 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 2.2 0.5 0.0 0.3 0.0 0.0 0.3 0.1 0.5 0.0 0.0 0.0 0.0 0.4 0.0 0.5 0.0 0.0 0.1 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.3 0.0 0.0 0.2 0.0 0.8 0.0 0.5 0.8 0.1 0.1 0.2 0.1 0.1 0.5 0.0 0.5 0.0 0.6 1.3 0.0 0.0 0.2 0.0 0.3 PA2G4 ENSG00000170515 "Proliferation-associated 2G4" Q9UQ80 12 56104319-56113907 "Enzymes, Plasma proteins, Predicted intracellular proteins" "rRNA processing, Transcription, Transcription regulation, Translation regulation" "Repressor, Ribonucleoprotein, RNA-binding" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "CAB011711, CAB012428, HPA016484" Supported Approved Cytosol 1200000 Cytosol "CAB011711: AB_732060, CAB012428: , HPA016484: AB_1854912" "unprognostic (5.53e-2)" "unprognostic (1.06e-1)" "unprognostic (2.35e-2)" "unprognostic (2.34e-2)" "unprognostic (3.87e-1)" "unprognostic (6.03e-3)" "prognostic unfavourable (6.31e-7)" "unprognostic (4.25e-3)" "unprognostic (2.77e-1)" "unprognostic (3.79e-3)" "unprognostic (2.29e-2)" "unprognostic (1.30e-2)" "prognostic unfavourable (4.59e-7)" "unprognostic (1.17e-1)" "unprognostic (2.01e-1)" "unprognostic (1.32e-1)" "unprognostic (4.67e-2)" 41.1 32.1 26.6 41.4 29.8 52.5 38.5 35.1 38.8 33.7 39.2 31.0 27.1 34.4 36.1 22.4 69.4 31.2 31.9 55.6 26.6 25.5 36.1 51.6 32.6 43.3 26.7 28.0 43.3 44.3 42.8 20.5 39.0 28.2 40.3 44.2 23.6 34.6 33.4 77.3 53.0 31.7 39.4 32.3 46.7 34.4 27.9 23.9 70.8 39.7 57.2 54.0 45.5 39.6 25.5 27.1 13.5 25.1 37.4 48.9 36.0 53.3 47.4 32.6 35.8 15.1 22.9 65.4 56.5 27.1 69.6 38.8 57.9 39.7 106.8 38.1 26.7 44.0 74.2 63.1 68.0 30.3 63.6 82.1 32.3 49.4 29.5 111.3 30.4 23.1 32.3 60.2 54.5 42.2 99.6 49.7 38.1 47.3 86.5 58.2 53.4 58.3 71.3 58.9 72.4 35.2 40.1 48.9 29.6 37.2 58.9 34.5 63.5 43.3 33.8 34.0 48.0 39.1 62.4 30.5 41.9 104.6 30.7 67.1 44.0 7.8 23.0 13.5 36.6 25.1 48.9 25.5 38.9 39.4 27.1 22.2 37.6 37.3 3.7 37.4 20.0 26.3 43.3 36.0 26.6 29.8 35.1 38.8 26.6 25.5 26.7 28.0 28.2 23.9 PAMR1 "DKFZP586H2123, RAMP" ENSG00000149090 "Peptidase domain containing associated with muscle regeneration 1" Q6UXH9 11 35431823-35530300 "Enzymes, Predicted intracellular proteins, Predicted secreted proteins" "Serine protease homolog" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell line enhanced" "Detected in some" "ASC diff: 17.5;ASC TERT1: 72.4;BJ hTERT+: 70.4;fHDF/TERT166: 16.7;HSkMC: 24.9;U-87 MG: 17.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" "Secreted - unknown location" 3300000 "unprognostic (3.38e-1)" "unprognostic (1.07e-2)" "unprognostic (1.67e-1)" "unprognostic (1.00e-3)" "unprognostic (6.50e-3)" "unprognostic (1.01e-1)" "unprognostic (2.07e-2)" "unprognostic (6.92e-2)" "unprognostic (3.32e-2)" "unprognostic (4.07e-2)" "unprognostic (1.91e-2)" "unprognostic (1.36e-2)" "prognostic unfavourable (5.08e-5)" "prognostic unfavourable (6.29e-4)" "unprognostic (2.08e-1)" "unprognostic (9.98e-2)" "unprognostic (8.25e-2)" 14.1 9.9 11.9 0.7 10.5 0.4 10.2 0.7 12.8 40.1 6.6 9.7 5.1 3.1 37.0 12.7 6.8 12.1 12.7 11.1 9.5 7.3 2.6 8.0 3.5 1.1 9.9 5.4 4.4 3.4 0.8 3.4 34.0 18.1 12.7 4.6 0.8 2.7 12.1 3.1 12.5 4.7 14.6 13.8 3.7 3.1 5.8 5.7 0.6 3.4 6.0 2.9 18.8 21.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 17.5 72.4 0.0 8.9 70.4 0.9 1.6 6.3 0.0 0.0 0.0 16.7 0.0 0.0 0.0 0.6 0.0 0.1 0.0 0.0 0.0 10.5 0.0 0.0 24.9 0.3 1.9 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 1.6 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 17.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 11.9 10.5 0.7 12.8 9.5 7.3 9.9 5.4 18.1 5.7 PAN2 "hPAN2, KIAA0710, USP52" ENSG00000135473 "PAN2 poly(A) specific ribonuclease subunit" Q504Q3 12 56316223-56334053 "Enzymes, Predicted intracellular proteins" "mRNA processing" "Exonuclease, Hydrolase, Nuclease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "unprognostic (2.43e-1)" "unprognostic (3.78e-1)" "unprognostic (1.21e-2)" "unprognostic (2.55e-1)" "unprognostic (1.67e-1)" "unprognostic (9.10e-3)" "unprognostic (1.03e-1)" "unprognostic (7.28e-2)" "unprognostic (7.35e-3)" "unprognostic (3.80e-1)" "unprognostic (1.74e-3)" "unprognostic (4.23e-3)" "prognostic unfavourable (2.77e-4)" "unprognostic (4.19e-1)" "unprognostic (3.87e-1)" "unprognostic (2.10e-1)" "unprognostic (2.68e-2)" 8.1 13.4 12.8 7.1 17.7 7.4 9.9 21.7 17.6 9.6 9.5 16.1 16.4 11.0 11.2 17.6 7.4 11.3 7.8 9.8 13.9 5.1 9.7 17.6 8.7 9.0 19.7 7.0 17.8 12.9 24.3 30.7 9.2 14.6 9.1 9.6 12.6 10.0 14.1 9.1 9.4 10.7 8.8 16.4 10.6 10.5 18.2 19.4 15.3 20.2 4.8 11.0 11.0 9.2 3.1 7.6 3.9 8.1 3.8 5.2 3.4 2.9 4.5 11.1 3.6 9.8 11.1 7.3 2.3 3.1 5.1 2.4 2.7 5.9 8.2 8.9 4.4 6.2 13.1 8.6 2.9 3.6 6.4 10.4 4.3 2.6 8.6 2.3 5.6 10.3 11.7 5.4 16.0 3.8 7.0 20.5 3.0 6.4 7.7 5.8 3.7 3.0 6.7 7.9 14.7 5.0 2.4 8.8 8.0 4.4 5.6 5.6 7.3 4.5 1.6 5.3 5.2 2.4 2.0 17.3 6.8 5.3 6.3 4.8 4.4 3.9 5.8 2.3 2.4 8.1 3.7 3.1 1.9 3.5 7.6 2.7 4.1 5.2 0.4 3.8 3.8 2.9 3.0 3.4 12.8 17.7 21.7 17.6 13.9 5.1 19.7 7.0 14.6 19.4 PAPPA "ASBABP2, DIPLA1, IGFBP-4ase, PAPA, PAPP-A, PAPPA1" ENSG00000182752 "Pappalysin 1" Q13219 9 116153804-116402322 "Cancer-related genes, Candidate cardiovascular disease genes, Enzymes, Plasma proteins, Predicted secreted proteins" "Hydrolase, Metalloprotease, Protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 86 "placenta: 484.6" "Cell line enhanced" "Detected in some" "ASC diff: 19.0;ASC TERT1: 14.5;HSkMC: 52.2;U-138 MG: 13.6" "Low cancer specificity" "Detected in some" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in some" "Group enriched" "Detected in many" 5 "midbrain: 10.4;olfactory region: 4.1;pons and medulla: 8.3;thalamus: 4.8" "HPA001667, CAB016724" Enhanced "Secreted in female reproductive system" 41000 "CAB016724: , HPA001667: AB_1854960" "unprognostic (3.25e-1)" "unprognostic (6.18e-6)" "unprognostic (2.47e-1)" "unprognostic (6.49e-2)" "unprognostic (2.01e-2)" "unprognostic (1.14e-1)" "unprognostic (1.13e-1)" "unprognostic (5.42e-3)" "unprognostic (5.44e-2)" "unprognostic (3.87e-2)" "unprognostic (6.87e-3)" "unprognostic (8.25e-2)" "unprognostic (8.00e-3)" "unprognostic (2.37e-3)" "unprognostic (2.48e-1)" "unprognostic (4.01e-1)" "unprognostic (1.02e-3)" 4.8 2.3 0.5 1.0 0.5 0.0 0.8 0.4 0.6 3.6 2.4 0.6 1.0 0.1 3.5 1.0 3.6 2.0 1.1 3.7 0.4 0.0 4.3 0.5 2.4 0.7 0.4 0.4 1.4 0.7 5.6 0.7 484.6 0.7 1.4 0.9 0.9 0.5 1.2 0.5 1.1 0.9 2.4 0.6 0.6 1.0 0.8 0.5 0.4 1.3 1.0 1.0 2.3 3.4 0.2 0.0 0.2 0.0 0.0 0.1 0.0 0.0 5.4 8.3 0.0 19.0 14.5 0.0 4.4 7.8 1.2 2.1 0.0 0.0 0.0 0.0 3.1 0.6 0.0 0.0 5.9 0.0 0.0 0.9 4.5 0.0 9.2 0.0 0.0 52.2 0.0 6.1 0.7 0.0 0.2 0.0 1.4 0.0 0.0 0.0 2.4 0.0 0.0 0.2 0.0 0.2 0.0 0.0 0.4 0.6 0.0 0.0 0.0 0.0 10.5 13.6 0.7 0.3 0.5 0.0 0.0 0.0 9.7 0.0 4.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.5 0.5 0.4 0.6 0.4 0.0 0.4 0.4 0.7 0.5 PAPPA2 "PAPP-A2, PAPPE, PLAC3" ENSG00000116183 "Pappalysin 2" Q9BXP8 1 176463171-176845605 "Enzymes, Predicted membrane proteins, Predicted secreted proteins" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 35 "placenta: 406.4" "Cell line enriched" "Detected in some" 5 "U-87 MG: 20.7" "Low cancer specificity" "Detected in some" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in many" "HPA018412, HPA018430" Enhanced Approved "Endoplasmic reticulum,Vesicles" "Secreted in female reproductive system" "Endoplasmic reticulum, Vesicles" "HPA018412: AB_1854962, HPA018430: AB_1854961" "unprognostic (2.90e-1)" "unprognostic (1.58e-1)" "unprognostic (1.07e-1)" "unprognostic (3.61e-2)" "unprognostic (9.04e-2)" "unprognostic (1.60e-3)" "unprognostic (1.36e-1)" "unprognostic (2.45e-1)" "unprognostic (1.00e-2)" "unprognostic (3.54e-2)" "unprognostic (1.29e-2)" "unprognostic (4.39e-2)" "unprognostic (2.85e-2)" "unprognostic (1.52e-4)" "unprognostic (1.85e-1)" "unprognostic (8.18e-4)" "unprognostic (4.35e-2)" 0.6 0.0 0.6 0.2 0.2 0.0 3.0 0.8 0.3 5.0 0.6 0.2 0.2 0.0 0.3 0.2 0.2 0.2 1.1 0.2 0.2 0.1 11.6 0.7 0.2 0.2 0.2 0.2 0.2 1.5 0.0 1.2 406.4 0.3 0.2 0.2 0.2 0.2 0.3 0.2 0.0 0.2 0.3 0.5 0.2 1.0 0.3 0.2 0.2 0.5 0.2 0.2 0.2 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.7 0.0 0.1 0.3 0.0 0.5 0.0 0.0 0.0 0.1 0.8 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 1.2 4.5 2.2 3.7 0.0 0.0 0.2 0.2 0.0 0.0 0.0 0.2 0.4 0.0 0.0 0.0 0.8 0.5 0.5 0.2 0.0 0.0 0.1 0.0 0.0 0.3 1.7 1.4 0.1 0.6 0.3 0.4 0.0 20.7 0.0 2.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.2 0.8 0.3 0.2 0.1 0.2 0.2 0.3 0.2 PARK7 "DJ-1, DJ1, GATD2" ENSG00000116288 "Parkinsonism associated deglycase" Q99497 1 7954291-7985505 "Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Autophagy, DNA damage, DNA repair, Fertilization, Inflammatory response, Stress response" "Chaperone, Hydrolase, Protease, RNA-binding" "Disease mutation, Neurodegeneration, Parkinson disease, Parkinsonism, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA004190, CAB005870" Supported Supported Nucleoplasm,Cytosol 69000000 "Nucleoplasm, Cytosol" "CAB005870: AB_444361, HPA004190: AB_1079566" "unprognostic (6.88e-3)" "unprognostic (7.50e-2)" "unprognostic (3.48e-2)" "unprognostic (1.16e-2)" "unprognostic (4.08e-2)" "unprognostic (5.68e-2)" "unprognostic (7.45e-2)" "unprognostic (9.63e-2)" "unprognostic (2.01e-1)" "unprognostic (1.66e-2)" "unprognostic (1.12e-1)" "unprognostic (2.02e-1)" "unprognostic (1.96e-3)" "unprognostic (8.17e-2)" "unprognostic (1.32e-1)" "unprognostic (1.30e-1)" "unprognostic (7.43e-2)" 44.6 67.9 69.3 38.1 64.9 33.7 45.4 57.2 62.7 34.0 36.4 33.4 43.2 27.3 35.8 56.6 40.9 39.0 41.6 71.7 56.9 57.2 60.5 77.1 28.6 46.1 61.6 57.2 45.9 60.4 66.6 48.4 44.6 41.2 44.7 39.5 38.6 46.5 39.4 128.7 19.8 27.5 48.1 52.5 37.5 37.2 38.2 32.2 38.8 71.6 43.3 46.5 41.3 43.4 49.5 141.8 38.8 61.0 52.8 87.2 90.6 68.2 61.5 61.3 70.4 66.0 63.5 30.1 63.6 59.6 62.6 50.6 56.0 74.8 84.7 71.9 68.2 49.0 66.1 85.0 81.4 75.3 71.4 91.0 91.9 83.1 57.0 86.8 56.1 59.8 36.3 63.8 76.7 65.6 88.3 63.1 86.8 63.9 60.4 110.3 50.0 63.5 46.5 82.3 116.1 98.2 35.1 71.7 60.2 63.6 98.3 99.2 54.8 64.7 62.1 57.8 46.1 53.3 69.7 61.3 98.3 120.5 76.2 132.9 81.8 22.7 61.0 38.8 52.6 55.4 49.7 49.5 52.7 62.2 73.9 38.6 45.6 52.4 21.0 52.8 44.1 141.8 87.2 90.6 69.3 64.9 57.2 62.7 56.9 57.2 61.6 57.2 41.2 32.2 PARL "PRO2207, PSARL, PSARL1, RHBDS1" ENSG00000175193 "Presenilin associated rhomboid like" Q9H300 3 183829271-183884933 "Enzymes, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" HPA019545 Approved Approved Mitochondria Mitochondria "HPA019545: AB_1855796" "unprognostic (2.10e-1)" "unprognostic (1.53e-3)" "unprognostic (5.88e-2)" "unprognostic (1.17e-2)" "unprognostic (5.76e-2)" "unprognostic (9.55e-2)" "unprognostic (3.17e-3)" "unprognostic (8.97e-2)" "unprognostic (1.81e-1)" "unprognostic (3.62e-3)" "unprognostic (1.52e-1)" "unprognostic (2.13e-2)" "unprognostic (4.28e-2)" "unprognostic (5.49e-2)" "unprognostic (2.58e-1)" "unprognostic (1.73e-1)" "prognostic favourable (9.11e-5)" 24.2 20.6 26.2 19.2 30.1 21.2 30.4 22.1 29.6 22.7 29.0 24.4 19.4 21.5 20.2 43.8 21.4 19.6 21.2 30.9 23.1 23.4 27.0 26.7 20.3 26.5 28.4 20.3 20.3 47.5 22.0 20.6 18.5 19.5 22.1 31.3 25.9 35.1 33.4 41.2 22.3 27.0 38.1 19.4 22.3 24.5 22.2 18.9 22.1 20.7 25.4 24.3 23.2 18.2 21.5 45.4 44.3 50.0 21.5 25.9 35.4 32.1 15.3 11.3 9.6 11.0 12.7 23.5 12.1 16.4 23.3 18.3 46.9 16.8 14.3 26.9 15.3 14.3 18.0 18.6 26.3 20.4 22.1 21.6 10.2 25.6 16.6 21.4 18.3 17.2 23.9 16.3 20.0 16.5 12.2 13.4 19.1 34.8 40.9 52.5 30.3 15.7 18.1 22.1 26.0 21.7 26.9 11.4 16.3 14.4 46.4 29.5 47.7 40.7 9.7 8.7 18.9 17.9 30.7 26.9 18.2 33.0 16.6 21.9 10.4 27.6 50.0 44.3 19.0 35.4 21.7 21.5 21.6 22.1 45.4 19.9 25.9 21.1 14.5 21.5 26.2 27.0 24.4 35.4 26.2 30.1 22.1 29.6 23.1 23.4 28.4 20.3 19.5 18.9 PCSK1 "NEC1, PC1, PC3, SPC3" ENSG00000175426 "Proprotein convertase subtilisin/kexin type 1" P29120 5 96390415-96434143 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Disease mutation, Obesity" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 36.6" "Group enriched" "Detected in some" 6 "SCLC-21H: 18.5;U-138 MG: 15.8;U-87 MG: 13.1" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Cell type enhanced" "Detected in single" "basophil: 1.8" "Lineage enhanced" "Detected in single" "granulocytes: 1.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" HPA048564 Approved "Secreted in other tissues" "HPA048564: " "unprognostic (1.86e-2)" "unprognostic (2.13e-2)" "unprognostic (4.66e-3)" "unprognostic (8.20e-5)" "prognostic unfavourable (9.13e-5)" "unprognostic (8.47e-4)" "unprognostic (1.46e-1)" "unprognostic (5.84e-3)" "unprognostic (4.71e-1)" "unprognostic (3.07e-3)" "unprognostic (1.89e-3)" "unprognostic (1.01e-1)" "unprognostic (7.90e-6)" "unprognostic (5.25e-2)" "unprognostic (9.96e-2)" "unprognostic (1.33e-3)" "unprognostic (9.37e-3)" 2.3 8.5 1.3 6.0 10.1 0.5 1.3 0.5 36.6 1.2 3.3 0.5 0.0 6.7 0.5 8.8 0.4 0.4 0.6 1.0 2.8 27.1 0.5 0.4 0.8 0.4 3.1 14.0 0.6 9.8 0.3 10.9 0.4 7.5 0.5 3.3 0.1 2.8 0.5 0.5 1.7 4.6 1.0 1.3 0.5 8.4 0.5 0.4 0.0 1.9 0.0 0.3 0.9 0.6 0.0 0.0 1.8 0.5 0.0 0.0 0.0 0.0 0.0 0.3 0.0 1.9 0.6 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.6 2.1 0.0 0.0 0.0 0.0 1.7 0.8 0.3 0.1 0.7 0.0 0.1 0.2 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 18.5 0.0 2.7 0.0 0.0 0.0 0.0 0.9 15.8 0.5 0.2 0.1 0.0 0.0 0.1 13.1 0.0 0.3 1.8 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.3 10.1 0.5 36.6 2.8 27.1 3.1 14.0 7.5 0.4 PCSK2 "NEC2, PC2, SPC2" ENSG00000125851 "Proprotein convertase subtilisin/kexin type 2" P16519 20 17226107-17484578 "Enzymes, Predicted intracellular proteins, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "adrenal gland: 35.0;thyroid gland: 79.5" "Group enriched" "Detected in some" 5 "AF22: 35.8;SCLC-21H: 9.4" "Group enriched" "Detected in many" 6 "pancreatic cancer: 14.6;thyroid cancer: 65.1" "Low region specificity" "Detected in all" "Cell type enriched" "Detected in single" 22 "basophil: 2.2" "Lineage enriched" "Detected in single" 22 "granulocytes: 2.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA049627 Approved Approved Vesicles "Secreted in other tissues" Vesicles "HPA049627: " "unprognostic (2.03e-3)" "unprognostic (1.61e-1)" "unprognostic (3.13e-1)" "unprognostic (2.18e-1)" "unprognostic (2.13e-1)" "unprognostic (6.84e-2)" "unprognostic (3.07e-3)" "unprognostic (4.31e-1)" "unprognostic (5.88e-2)" "unprognostic (2.50e-3)" "unprognostic (2.14e-1)" "unprognostic (7.26e-5)" "unprognostic (2.29e-1)" "unprognostic (1.57e-1)" "unprognostic (2.35e-1)" "unprognostic (1.14e-1)" 1.6 35.0 16.3 1.7 20.5 1.3 1.3 7.7 27.8 2.9 4.2 1.6 0.0 6.2 0.9 1.2 2.1 2.0 1.4 3.1 18.0 11.1 1.1 1.0 2.2 0.8 4.1 16.2 11.6 23.7 0.9 1.7 1.5 9.0 1.3 2.8 16.6 2.7 2.3 1.0 16.6 3.3 1.3 5.4 0.9 11.9 4.7 3.8 0.0 79.5 0.0 0.9 1.9 1.8 0.0 0.0 2.2 0.0 0.0 0.0 0.0 0.0 0.0 35.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 4.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 9.4 0.1 0.0 0.0 1.5 0.0 0.0 0.0 0.1 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 2.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 16.3 20.5 7.7 27.8 18.0 11.1 4.1 16.2 9.0 3.8 PCSK4 "DKFZp434B217, MGC34749, PC4, SPC5" ENSG00000115257 "Proprotein convertase subtilisin/kexin type 4" Q6UW60 19 1481428-1490752 "Enzymes, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 12 "testis: 50.7" "Cell line enhanced" "Detected in some" "AN3-CA: 9.9;HMC-1: 5.3;U-266/70: 10.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Cell type enhanced" "Detected in some" "naive CD4 T-cell: 1.2;plasmacytoid DC: 1.7" "Group enriched" "Detected in many" 4 "dendritic cells: 1.7;T-cells: 1.2" "Low region specificity" "Detected in single" "Not detected" "Not detected" HPA005572 Uncertain "HPA005572: AB_1855087" "unprognostic (1.00e-2)" "unprognostic (9.12e-2)" "unprognostic (2.36e-3)" "prognostic favourable (9.45e-5)" "unprognostic (5.23e-2)" "unprognostic (6.14e-2)" "unprognostic (1.78e-1)" "unprognostic (6.34e-3)" "unprognostic (2.94e-1)" "unprognostic (8.29e-3)" "unprognostic (1.93e-2)" "unprognostic (7.44e-2)" "unprognostic (6.56e-2)" "unprognostic (3.82e-2)" "unprognostic (1.71e-2)" "unprognostic (3.57e-2)" "unprognostic (7.03e-2)" 0.5 1.2 2.5 0.6 3.4 0.9 0.7 0.6 1.8 1.2 0.9 1.8 2.5 2.5 0.8 2.2 0.7 4.2 1.0 0.4 2.5 2.1 1.7 2.0 0.8 0.6 1.0 2.0 0.8 3.8 1.4 4.2 0.5 2.3 1.2 0.4 2.4 1.3 2.4 0.5 0.8 1.1 0.6 1.2 0.7 1.2 50.7 1.8 1.2 2.0 0.0 0.4 0.7 0.6 0.0 1.7 0.0 0.3 0.0 1.2 0.1 0.8 0.5 1.7 9.9 0.2 0.3 2.6 0.7 0.2 0.1 0.3 0.9 1.4 0.0 1.0 0.0 1.1 0.0 0.0 0.0 0.6 0.2 0.4 1.4 1.3 0.7 0.0 5.3 0.8 0.0 0.0 0.1 0.2 1.6 2.5 0.0 0.0 0.2 0.4 0.1 0.5 1.7 0.1 0.2 0.6 0.0 0.0 2.0 0.2 0.4 0.1 3.6 0.5 0.0 0.8 0.1 0.2 0.0 10.9 1.9 0.3 0.5 0.9 0.4 0.0 0.0 0.0 0.1 0.3 0.0 0.0 0.5 0.2 0.0 0.0 1.2 0.1 0.0 0.0 0.0 1.7 0.0 0.1 2.5 3.4 0.6 1.8 2.5 2.1 1.0 2.0 2.3 1.8 PCSK5 "PC5, PC6, SPC6" ENSG00000099139 "Proprotein convertase subtilisin/kexin type 5" Q92824 9 75890644-76362339 "Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins" Pregnancy "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in all" 5 "blood: 157.6;intestine: 71.5" "Cell line enhanced" "Detected in many" "BEWO: 15.5;HaCaT: 21.8;RH-30: 14.4;RPTEC TERT1: 20.2;U-2 OS: 31.5" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Group enriched" "Detected in all" 7 "basophil: 157.6;neutrophil: 57.4" "Lineage enriched" "Detected in all" 12 "granulocytes: 157.6" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA031072 Approved Supported "Golgi apparatus" "Secreted to blood" "Golgi apparatus" "HPA031072: AB_10602190" "unprognostic (3.28e-2)" "unprognostic (1.44e-1)" "unprognostic (4.13e-4)" "unprognostic (4.08e-2)" "unprognostic (7.43e-3)" "unprognostic (3.17e-1)" "unprognostic (2.07e-3)" "unprognostic (9.39e-2)" "unprognostic (1.15e-1)" "unprognostic (5.92e-2)" "unprognostic (2.81e-2)" "unprognostic (6.80e-2)" "prognostic unfavourable (9.61e-5)" "unprognostic (2.99e-1)" "unprognostic (3.21e-2)" "unprognostic (3.22e-2)" "unprognostic (1.77e-5)" 15.8 3.8 2.9 13.7 2.8 1.5 9.5 2.4 3.2 8.5 51.8 2.9 4.5 19.7 6.5 13.9 9.6 7.8 22.9 6.7 3.8 2.4 3.7 1.9 7.7 5.6 2.3 3.1 17.2 3.4 9.5 3.2 7.7 3.5 4.5 6.7 3.3 5.0 5.8 4.0 4.8 71.5 6.9 3.5 2.5 3.3 5.1 2.4 18.0 6.4 14.2 4.5 7.1 11.4 11.7 12.2 157.6 4.4 12.6 12.7 0.8 1.1 0.8 2.4 1.6 1.5 0.5 15.5 2.1 0.2 0.1 0.0 8.2 0.9 0.3 0.6 0.2 21.8 1.1 0.6 0.1 0.2 1.9 2.8 1.6 0.7 0.4 0.8 1.3 2.9 0.2 0.5 0.2 4.5 3.2 1.0 1.5 5.1 3.2 4.9 10.6 0.9 0.6 14.4 0.8 20.2 1.2 0.2 0.2 3.3 0.7 0.2 1.2 3.5 3.5 0.7 31.5 1.8 0.9 0.2 0.1 0.4 2.4 1.2 12.0 157.6 4.2 16.2 9.7 2.3 8.3 8.8 9.8 8.9 1.9 11.7 9.9 12.7 57.4 12.6 4.4 12.2 8.4 0.8 2.9 2.8 2.4 3.2 3.8 2.4 2.3 3.1 3.5 2.4 PCSK6 "PACE4, SPC4" ENSG00000140479 "Proprotein convertase subtilisin/kexin type 6" P29122 15 101297142-101525202 "Enzymes, Predicted intracellular proteins, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 69.3;liver: 76.0;lymphoid tissue: 37.4" "Cell line enhanced" "Detected in many" "BEWO: 26.1;CACO-2: 18.3;HEK 293: 27.5;Hep G2: 24.6" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Cell type enhanced" "Detected in many" "NK-cell: 7.5" "Low lineage specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA004774 Uncertain "Secreted to extracellular matrix" 38000 "HPA004774: AB_1079583" "prognostic favourable (9.99e-4)" "unprognostic (1.09e-1)" "unprognostic (4.37e-2)" "unprognostic (2.46e-2)" "unprognostic (9.83e-2)" "unprognostic (8.14e-2)" "unprognostic (2.20e-3)" "unprognostic (8.56e-2)" "unprognostic (2.16e-1)" "unprognostic (2.39e-2)" "unprognostic (3.85e-3)" "unprognostic (2.01e-1)" "prognostic unfavourable (7.06e-7)" "unprognostic (2.02e-1)" "unprognostic (1.87e-1)" "unprognostic (1.15e-1)" "unprognostic (1.03e-2)" 3.0 1.5 5.1 1.5 25.1 0.9 6.1 4.5 11.5 1.5 8.4 41.9 0.0 3.6 1.4 2.5 4.8 1.9 1.9 10.1 8.9 5.7 1.7 76.0 2.3 4.6 38.8 8.4 4.0 1.7 0.5 3.1 16.5 29.0 1.9 8.2 0.7 1.5 0.7 3.5 4.0 4.8 1.9 69.3 37.4 5.3 6.6 24.5 3.7 1.4 3.5 1.3 1.6 1.6 2.6 0.7 1.9 2.4 7.5 1.4 2.5 8.6 7.0 1.3 0.9 0.1 0.1 26.1 0.5 1.3 0.0 0.1 18.3 4.0 0.2 1.2 0.2 5.9 7.0 0.7 0.1 1.2 27.5 15.0 3.6 24.6 0.8 2.1 0.3 0.4 4.8 0.1 0.2 0.0 11.5 0.2 0.0 4.2 0.1 1.9 3.7 3.0 0.2 0.2 1.9 2.3 12.2 3.5 3.8 12.1 0.9 3.9 1.0 9.5 0.1 0.1 0.7 0.2 0.0 0.3 0.3 0.3 0.1 0.3 3.4 1.3 0.6 1.9 0.6 0.8 0.7 1.1 1.0 0.5 0.2 2.6 1.4 1.3 1.1 7.5 2.4 0.7 0.2 2.5 5.1 25.1 4.5 10.4 8.9 5.7 38.8 8.4 29.0 24.5 PCSK7 "LPC, PC7, PC8, SPC7" ENSG00000160613 "Proprotein convertase subtilisin/kexin type 7" Q16549 11 117204337-117232525 "Enzymes, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "unprognostic (7.11e-2)" "unprognostic (2.90e-2)" "unprognostic (8.33e-3)" "unprognostic (4.24e-2)" "unprognostic (1.32e-1)" "unprognostic (2.77e-2)" "unprognostic (1.56e-1)" "unprognostic (2.60e-1)" "unprognostic (1.96e-1)" "unprognostic (2.41e-1)" "unprognostic (8.80e-2)" "unprognostic (1.09e-1)" "unprognostic (1.02e-1)" "unprognostic (1.51e-1)" "unprognostic (1.06e-1)" "unprognostic (1.00e-1)" "unprognostic (3.03e-2)" 19.4 11.6 11.9 28.7 13.9 11.3 14.4 12.9 16.5 15.0 44.8 15.4 13.4 20.4 47.9 9.4 27.3 23.9 20.7 12.2 10.4 5.2 9.9 11.5 14.5 19.7 18.7 14.1 11.5 14.9 6.2 12.8 18.3 13.3 24.0 17.7 9.6 14.1 11.4 12.8 11.4 20.3 9.2 9.7 16.8 28.4 6.3 13.9 17.8 10.4 13.7 25.3 34.6 13.0 12.7 4.2 4.2 5.3 19.6 19.7 8.7 5.6 10.6 8.7 8.1 9.6 7.3 7.2 22.2 9.1 10.2 9.8 23.8 34.8 9.0 22.2 15.9 19.9 9.8 13.2 6.4 14.0 9.1 13.4 15.4 7.0 11.5 8.5 21.5 13.9 8.2 13.7 9.2 17.5 8.3 8.2 14.3 8.2 11.3 9.8 7.3 10.4 8.3 7.1 11.4 12.3 13.7 11.4 13.7 16.2 21.0 3.0 13.0 7.7 16.2 24.4 8.1 13.7 14.6 5.6 3.4 5.7 7.9 12.3 14.6 3.9 3.3 4.2 19.5 4.7 16.4 12.7 15.2 17.8 3.7 9.6 11.0 12.7 2.8 19.6 5.3 4.2 19.7 8.7 11.9 13.9 12.9 16.5 10.4 5.2 18.7 14.1 13.3 13.9 PCSK9 "FH3, HCHOLA3, NARC-1" ENSG00000169174 "Proprotein convertase subtilisin/kexin type 9" Q8NBP7 1 55039548-55064852 "Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins" "Apoptosis, Cholesterol metabolism, Lipid metabolism, Steroid metabolism, Sterol metabolism" "Hydrolase, Protease, Serine protease" "Disease mutation, FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "liver: 47.1;lung: 14.6" "Cell line enhanced" "Detected in some" "A-431: 28.4;HaCaT: 38.1;HeLa: 33.2;RPTEC TERT1: 18.8" "Low cancer specificity" "Detected in many" "Group enriched" "Detected in some" 9 "cerebellum: 6.9;pons and medulla: 2.6" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in some" "Not detected" "Not detected" "Secreted to blood" 143000000 300000000 "unprognostic (1.28e-3)" "unprognostic (6.93e-2)" "unprognostic (4.02e-1)" "unprognostic (2.19e-2)" "unprognostic (7.30e-2)" "unprognostic (1.82e-1)" "unprognostic (1.20e-3)" "unprognostic (1.14e-2)" "unprognostic (5.44e-3)" "unprognostic (1.22e-2)" "unprognostic (2.09e-3)" "unprognostic (3.70e-2)" "unprognostic (2.45e-4)" "unprognostic (1.49e-1)" "unprognostic (1.86e-1)" "unprognostic (2.13e-1)" "prognostic unfavourable (2.40e-4)" 0.2 0.1 0.0 6.1 0.5 0.4 0.0 6.9 0.2 0.6 4.4 0.0 0.0 3.9 0.2 0.7 5.2 0.4 2.6 0.0 0.0 0.0 0.1 47.1 14.6 0.0 0.1 0.0 0.1 11.0 0.0 0.0 0.0 2.6 0.0 1.9 0.1 0.3 0.3 0.0 0.8 5.1 0.8 0.1 0.2 1.0 0.4 0.0 0.0 0.0 6.1 0.9 0.6 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 28.4 6.3 0.9 0.0 2.1 1.4 0.0 0.0 0.0 0.0 0.0 13.2 4.5 0.0 5.2 2.5 38.1 1.1 11.6 0.0 0.0 0.0 0.0 33.2 9.2 0.7 0.0 0.0 2.2 8.6 8.4 6.1 0.0 3.6 0.0 0.0 0.0 0.0 0.0 5.4 0.6 0.0 0.0 0.3 18.8 0.0 0.5 0.0 3.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 6.9 0.2 0.0 0.0 0.1 0.0 2.6 0.0 PEPD ENSG00000124299 "Peptidase D" P12955 19 33386950-33521794 "Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Collagen degradation" "Dipeptidase, Hydrolase, Metalloprotease, Protease" "Disease mutation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "intestine: 92.9;kidney: 106.0" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA015599, HPA072045" Enhanced Approved Nucleoplasm 1000000000 Nucleoplasm "HPA015599: AB_1855192, HPA072045: " "unprognostic (1.39e-1)" "unprognostic (2.62e-2)" "unprognostic (2.27e-1)" "unprognostic (4.01e-2)" "unprognostic (2.98e-1)" "unprognostic (6.77e-2)" "unprognostic (2.82e-1)" "unprognostic (3.64e-2)" "unprognostic (3.96e-1)" "unprognostic (5.10e-2)" "unprognostic (1.11e-2)" "unprognostic (1.99e-1)" "prognostic favourable (6.50e-9)" "unprognostic (4.38e-2)" "unprognostic (1.99e-1)" "unprognostic (1.65e-1)" "unprognostic (1.29e-1)" 23.5 17.2 9.8 8.9 10.4 4.1 21.8 7.6 14.9 9.8 60.1 18.7 6.9 58.1 14.3 11.5 14.9 9.6 13.6 8.0 10.8 9.1 106.0 48.6 11.1 10.6 16.0 7.7 12.6 9.0 9.6 12.5 10.4 13.0 9.2 6.6 13.3 9.6 9.0 9.7 11.4 92.9 10.4 17.4 13.4 9.3 8.4 11.5 8.4 15.0 9.7 10.6 11.9 11.9 17.1 32.3 27.5 39.1 16.8 25.8 32.6 13.2 35.9 10.6 17.0 45.2 17.4 24.5 11.7 24.1 15.0 17.1 31.2 11.6 5.4 17.6 29.5 3.4 15.2 9.6 12.4 15.2 15.0 34.3 7.3 31.7 30.9 9.9 41.6 21.4 9.1 13.7 8.5 20.0 6.5 15.6 16.3 16.1 7.6 3.3 14.6 14.6 15.0 14.4 14.9 13.0 34.9 13.0 33.4 21.9 10.8 17.7 7.5 10.8 16.7 14.5 15.7 18.8 13.6 14.3 21.2 4.7 15.5 14.4 20.6 27.5 36.1 2.5 25.8 39.1 22.6 17.1 25.7 23.8 32.3 16.3 16.9 19.6 1.9 16.8 27.2 9.9 23.6 32.6 9.8 10.4 7.6 14.9 10.8 9.1 16.0 7.7 13.0 11.5 PGA3 ENSG00000229859 "Pepsinogen 3, group I (pepsinogen A)" P0DJD8 11 61203307-61213098 "Enzymes, Predicted intracellular proteins, Predicted secreted proteins" Digestion "Aspartyl protease, Hydrolase, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 28 "stomach 1: 1048.8" "Group enriched" "Detected in some" 5 "HMC-1: 13.4;THP-1: 4.4" "Cancer enriched" "Detected in single" 498 "stomach cancer: 24.8" "Region enriched" "Detected in single" 15 "cerebral cortex: 4.8" "Cell type enhanced" "Detected in many" "intermediate monocyte: 6.7" "Lineage enriched" "Detected in many" 4 "monocytes: 6.7" "CAB026358, HPA046875" Enhanced "Secreted to digestive system" "CAB026358: , HPA046875: " "unprognostic (6.39e-2)" "unprognostic (1.11e-1)" 0.3 0.1 0.0 0.2 0.3 0.0 0.3 0.0 4.8 0.2 0.4 19.9 0.0 0.1 0.1 0.5 36.8 0.2 0.0 0.4 0.0 0.0 0.5 0.2 0.1 0.0 0.0 0.0 0.4 17.7 0.0 0.0 0.2 0.0 0.2 0.0 0.1 2.0 0.1 0.1 0.0 0.0 0.7 0.0 1.4 1048.8 0.1 0.0 0.0 0.1 3.8 0.0 0.1 0.0 0.3 0.3 1.1 6.7 0.5 1.5 3.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 1.7 0.0 0.0 0.0 0.1 0.0 1.0 0.0 1.1 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.0 0.0 0.0 13.4 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.8 0.0 0.3 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 4.4 0.0 0.0 1.3 0.4 0.0 0.9 0.0 0.1 0.0 0.0 0.0 0.5 4.3 0.2 1.5 6.7 0.9 0.2 0.5 1.4 0.3 0.3 0.2 1.4 1.1 0.5 1.7 0.2 0.1 3.0 0.0 0.3 0.0 4.8 0.0 0.0 0.0 0.0 0.0 0.0 PGA4 ENSG00000229183 "Pepsinogen 4, group I (pepsinogen A)" P0DJD7 11 61222216-61231927 "Enzymes, Predicted intracellular proteins, Predicted secreted proteins" Digestion "Aspartyl protease, Hydrolase, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 120 "stomach 1: 924.0" "Group enriched" "Detected in some" 8 "BJ hTERT+: 17.2;THP-1: 8.7" "Not detected" "Not detected" "Group enriched" "Detected in some" 16 "classical monocyte: 7.6;intermediate monocyte: 5.9;non-classical monocyte: 2.1" "Lineage enriched" "Detected in single" 23 "monocytes: 7.6" HPA046875 Supported "Secreted to digestive system" "HPA046875: " "unprognostic (2.22e-1)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 924.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.1 7.6 0.0 0.1 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 17.2 0.0 0.0 0.0 0.0 0.0 1.5 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 1.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.1 1.4 0.0 1.2 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 8.7 0.0 0.0 0.0 0.2 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 7.6 0.0 0.0 5.9 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.1 0.1 0.0 2.1 0.0 0.0 1.4 PGA5 ENSG00000256713 "Pepsinogen 5, group I (pepsinogen A)" P0DJD9 11 61241042-61251448 "Enzymes, Predicted intracellular proteins, Predicted secreted proteins" Digestion "Aspartyl protease, Hydrolase, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 38 "stomach 1: 296.9" "Cell line enriched" "Detected in some" 14 "BJ hTERT+: 25.1" "Cancer enriched" "Detected in some" 12 "stomach cancer: 15.0" "Group enriched" "Detected in some" 50 "classical monocyte: 3.4;intermediate monocyte: 7.7;non-classical monocyte: 3.7" "Lineage enriched" "Detected in single" 77 "monocytes: 7.7" HPA046875 Supported "Secreted to digestive system" "HPA046875: " "unprognostic (1.36e-3)" "unprognostic (2.98e-2)" "unprognostic (5.83e-3)" "unprognostic (2.11e-1)" "unprognostic (4.22e-1)" "unprognostic (4.36e-2)" "unprognostic (2.16e-2)" "unprognostic (1.05e-1)" "unprognostic (7.10e-2)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 296.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 7.7 0.0 0.0 0.6 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 25.1 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 1.7 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.3 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 3.4 0.0 0.0 7.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.7 0.0 0.0 0.6 PGC ENSG00000096088 Progastricsin P20142 6 41736711-41754109 "Cancer-related genes, Enzymes, Predicted intracellular proteins, Predicted secreted proteins, Transporters" Digestion "Aspartyl protease, Hydrolase, Protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 5 "ductus deferens: 249.6;pancreas: 798.6;stomach 1: 963.7" "Cell line enriched" "Detected in some" 13 "Hep G2: 73.2" "Cancer enhanced" "Detected in many" "stomach cancer: 1050.3" "Not detected" "Not detected" "Cell type enriched" "Detected in single" 7 "intermediate monocyte: 1.9" "Lineage enriched" "Detected in single" 7 "monocytes: 1.9" "Not detected" "Not detected" "Not detected" "Not detected" "HPA031717, HPA031718" Enhanced Approved Nucleoplasm "Secreted to digestive system" Nucleoplasm "HPA031717: AB_10670130, HPA031718: AB_10610148" "unprognostic (9.18e-2)" "unprognostic (1.87e-1)" "unprognostic (9.83e-2)" "unprognostic (2.27e-1)" "unprognostic (7.18e-2)" "unprognostic (2.74e-1)" "unprognostic (1.47e-1)" "unprognostic (8.50e-2)" "unprognostic (1.86e-1)" "unprognostic (9.23e-2)" "unprognostic (1.09e-1)" "unprognostic (1.33e-2)" "unprognostic (2.92e-1)" "unprognostic (1.65e-1)" "unprognostic (8.74e-2)" 0.1 0.2 0.1 0.0 0.1 0.0 0.2 0.1 0.1 0.3 0.1 3.0 249.6 41.7 0.1 0.0 3.3 0.3 16.8 0.1 0.1 0.1 0.1 0.3 139.4 0.0 0.1 0.0 0.1 798.6 0.0 0.1 0.0 0.1 2.3 0.0 0.0 0.1 35.9 0.1 0.1 0.1 0.0 0.1 0.1 963.7 0.1 0.0 0.0 0.1 0.0 0.0 0.4 0.2 0.0 0.0 0.0 1.9 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.7 0.0 0.0 0.0 0.0 5.4 0.0 0.0 0.1 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 73.2 0.0 0.1 1.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.2 1.7 0.0 0.8 0.0 1.7 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.8 0.0 0.0 1.1 0.0 0.0 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.2 1.9 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.0 0.1 0.0 PGPEP1 "Pcp, PGP, PGP-I, PGPI" ENSG00000130517 "Pyroglutamyl-peptidase I" Q9NXJ5 19 18340587-18369950 "Enzymes, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell line enhanced" "Detected in many" "HMC-1: 33.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA035368, HPA055277" Approved Approved "Golgi apparatus" "Golgi apparatus" "HPA035368: AB_10601388, HPA055277: " "unprognostic (9.52e-3)" "unprognostic (1.37e-2)" "unprognostic (6.95e-2)" "unprognostic (5.74e-3)" "unprognostic (5.29e-2)" "unprognostic (6.60e-2)" "unprognostic (1.96e-2)" "unprognostic (2.11e-3)" "prognostic favourable (6.80e-4)" "unprognostic (2.79e-2)" "prognostic favourable (1.71e-4)" "unprognostic (4.81e-3)" "prognostic favourable (3.71e-8)" "unprognostic (1.12e-2)" "unprognostic (1.66e-1)" "unprognostic (1.51e-1)" "unprognostic (1.20e-3)" 11.0 18.6 14.8 10.1 14.9 12.4 10.7 8.1 12.5 13.9 23.3 14.8 25.3 23.6 8.2 16.0 6.3 10.0 16.7 20.6 18.2 15.4 29.9 29.7 9.4 11.4 17.8 7.3 13.2 26.6 15.1 17.1 7.5 12.5 13.4 17.2 13.7 22.8 23.6 25.2 3.6 33.6 12.1 25.5 16.2 15.4 4.2 15.6 8.6 11.5 7.4 7.0 12.8 10.0 3.9 3.3 17.6 6.1 4.3 4.9 3.6 4.7 7.5 6.2 6.3 7.9 6.2 7.6 5.6 8.8 3.9 5.8 5.3 10.1 7.2 9.5 9.2 1.2 2.4 1.3 2.2 8.5 2.7 7.9 7.5 14.8 11.2 4.6 33.2 6.3 2.8 3.0 0.5 5.8 14.5 11.0 3.2 7.6 4.7 3.7 6.3 2.3 0.0 2.3 6.4 4.2 7.4 2.2 3.5 1.1 0.6 10.0 2.8 9.5 8.9 4.5 3.0 5.8 2.4 13.7 6.5 4.3 12.0 13.2 4.1 17.6 5.4 7.1 4.9 5.4 2.8 2.0 3.4 4.4 3.3 3.9 4.3 4.0 3.1 4.3 6.1 2.2 3.8 3.6 14.8 14.9 8.1 12.5 18.2 15.4 17.8 7.3 12.5 15.6 PGPEP1L ENSG00000183571 "Pyroglutamyl-peptidase I-like" A6NFU8 15 98968230-99007795 "Enzymes, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Tissue enriched" "Detected in some" 4 "skeletal muscle: 34.7" "Cell line enhanced" "Detected in some" "HeLa: 1.9;U-2 OS: 4.4" "Not detected" "Not detected" "Low region specificity" "Detected in single" "Group enriched" "Detected in some" 6 "basophil: 2.0;neutrophil: 1.9" "Lineage enriched" "Detected in single" 6 "granulocytes: 2.0" "Not detected" "Not detected" HPA041781 Uncertain "HPA041781: AB_10795642" "unprognostic (2.48e-1)" "unprognostic (2.82e-2)" "unprognostic (8.26e-2)" "unprognostic (2.43e-3)" "unprognostic (7.18e-2)" "unprognostic (3.99e-2)" "unprognostic (1.69e-1)" "unprognostic (5.44e-2)" "unprognostic (9.78e-2)" "unprognostic (1.58e-1)" "unprognostic (4.53e-3)" "unprognostic (1.86e-1)" "unprognostic (2.62e-1)" "unprognostic (2.00e-2)" "unprognostic (1.65e-1)" 0.7 0.1 0.5 0.2 1.4 0.1 0.6 0.2 0.5 0.4 0.4 0.4 0.0 0.2 0.2 0.4 0.8 0.2 0.5 3.6 0.6 0.4 0.4 0.0 0.2 0.3 0.4 0.2 0.2 0.5 0.0 0.1 0.3 0.4 0.6 0.0 1.6 0.9 0.5 34.7 0.1 0.2 0.3 0.3 0.1 0.2 5.0 0.2 0.1 0.1 8.6 0.5 0.2 0.3 0.0 0.0 2.0 0.0 0.0 0.3 0.0 0.0 0.0 0.2 0.0 0.0 0.2 1.1 0.7 0.0 0.2 0.1 0.0 0.0 0.5 0.2 0.0 0.0 0.0 0.0 0.0 0.7 0.2 0.0 1.9 0.0 0.3 0.5 0.0 0.0 0.0 0.1 0.2 0.0 0.9 1.4 0.1 0.0 0.2 0.4 1.3 0.4 0.4 0.1 1.2 0.0 0.9 0.3 0.4 0.5 1.4 0.2 0.8 0.0 0.7 0.0 4.4 0.2 0.1 0.8 0.2 0.7 0.0 0.5 0.0 2.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 1.9 0.0 0.0 0.0 0.0 0.0 0.5 1.4 0.2 0.5 0.6 0.4 0.4 0.2 0.4 0.2 PHEX "HPDR, HPDR1, HYP, HYP1, PEX, XLH" ENSG00000102174 "Phosphate regulating endopeptidase homolog X-linked" P78562 X 22032441-22251310 "Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted membrane proteins" Biomineralization "Hydrolase, Metalloprotease, Protease" "Disease mutation" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "blood: 8.3;lung: 6.7" "Cell line enhanced" "Detected in some" "HBEC3-KT: 5.6;HUVEC TERT2: 4.3;PC-3: 4.7;TIME: 4.8;U-87 MG: 10.3;WM-115: 4.3" "Cancer enhanced" "Detected in some" "thyroid cancer: 5.9" "Low region specificity" "Detected in many" "Cell type enriched" "Detected in single" 37 "plasmacytoid DC: 8.3" "Lineage enriched" "Detected in single" 37 "dendritic cells: 8.3" "Low region specificity" "Detected in some" "Low region specificity" "Detected in many" "unprognostic (2.01e-2)" "unprognostic (2.69e-1)" "unprognostic (2.43e-1)" "unprognostic (1.05e-3)" "unprognostic (1.22e-1)" "unprognostic (3.04e-2)" "unprognostic (2.25e-3)" "unprognostic (1.23e-1)" "unprognostic (1.87e-1)" "unprognostic (1.21e-2)" "unprognostic (7.53e-2)" "unprognostic (7.45e-2)" "unprognostic (9.84e-8)" "unprognostic (1.18e-1)" "unprognostic (1.58e-1)" "prognostic favourable (2.51e-4)" "unprognostic (7.68e-2)" 0.3 0.0 1.8 1.9 1.1 0.0 1.7 0.9 1.1 0.8 0.9 0.8 0.3 1.2 5.0 0.3 0.4 0.1 2.0 0.3 1.5 1.8 0.3 0.3 6.7 3.4 2.0 0.3 3.9 0.3 0.0 0.3 0.3 5.0 1.3 0.0 0.3 2.8 0.9 0.3 0.1 1.4 3.9 3.8 3.4 0.0 0.3 0.3 1.3 4.8 0.3 4.3 0.5 0.6 0.1 8.3 0.0 0.0 0.0 0.2 0.0 0.3 0.8 0.2 0.1 0.1 0.4 0.0 0.0 0.1 0.1 0.3 1.3 0.1 0.1 1.3 0.1 0.1 0.0 5.6 0.3 0.0 0.1 0.1 0.5 0.0 0.1 0.1 0.2 2.2 1.1 1.1 3.3 4.3 0.0 0.4 0.5 0.0 0.0 0.2 0.0 4.7 0.0 1.0 0.0 0.6 0.2 0.1 0.2 0.4 2.4 0.8 2.8 0.0 4.8 1.0 0.1 0.6 0.8 0.0 0.0 0.0 10.3 0.0 4.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 8.3 0.0 0.0 1.8 1.1 0.9 1.1 1.5 1.8 2.0 0.3 5.0 0.3 PIGK "GPI8, hGPI8" ENSG00000142892 "Phosphatidylinositol glycan anchor biosynthesis class K" Q92643 1 77088990-77219430 "Enzymes, Predicted intracellular proteins, Predicted membrane proteins" "GPI-anchor biosynthesis" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA056383, HPA057040" Uncertain "Intracellular and membrane" "HPA056383: , HPA057040: " "unprognostic (2.43e-2)" "unprognostic (2.60e-1)" "unprognostic (4.07e-2)" "unprognostic (2.24e-2)" "unprognostic (3.65e-1)" "unprognostic (1.15e-1)" "prognostic unfavourable (4.68e-4)" "unprognostic (1.07e-1)" "unprognostic (5.19e-1)" "unprognostic (1.12e-1)" "unprognostic (4.17e-2)" "unprognostic (1.85e-2)" "unprognostic (1.76e-2)" "unprognostic (3.37e-1)" "unprognostic (1.38e-1)" "unprognostic (1.21e-1)" "unprognostic (8.12e-3)" 14.5 17.4 13.8 8.0 20.4 10.2 17.1 14.8 22.9 14.2 11.4 17.4 9.6 9.2 14.6 13.8 10.7 13.0 13.6 20.0 15.4 17.7 25.4 19.0 12.3 10.6 17.7 11.7 13.7 14.1 24.9 23.1 11.2 23.8 15.9 12.9 11.2 11.9 12.9 11.9 7.6 11.6 14.5 19.9 14.7 11.6 9.6 17.2 14.6 22.3 8.1 9.8 12.9 9.4 5.2 7.6 7.6 4.4 8.9 12.8 6.3 5.6 6.6 5.5 7.0 31.9 24.0 9.0 11.5 15.9 12.1 17.4 5.5 5.8 5.0 11.9 20.3 5.1 7.0 9.8 22.1 10.2 7.2 6.7 7.2 5.1 7.1 14.9 6.0 14.4 5.3 12.9 11.2 17.8 8.2 17.1 18.6 3.8 4.7 6.0 4.9 11.1 5.5 16.3 6.3 15.4 4.1 4.7 4.4 10.9 10.0 12.5 4.8 8.5 10.1 19.6 7.7 10.5 11.7 7.8 10.8 5.0 14.5 18.9 7.7 6.9 4.1 7.6 8.3 4.4 8.4 5.2 8.5 7.0 7.6 4.1 10.7 9.5 2.0 8.9 4.2 5.2 12.8 6.3 13.8 20.4 14.8 22.9 15.4 17.7 17.7 11.7 23.8 17.2 PITRM1 "hMP1, KIAA1104, MP1, PreP" ENSG00000107959 "Pitrilysin metallopeptidase 1" Q5JRX3 10 3137728-3172841 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA006753, HPA006754" Enhanced Supported Mitochondria Mitochondria "HPA006753: AB_1079624, HPA006754: AB_1079623" "unprognostic (1.83e-3)" "unprognostic (7.01e-3)" "unprognostic (2.19e-1)" "unprognostic (1.69e-1)" "unprognostic (3.20e-2)" "unprognostic (6.67e-2)" "unprognostic (1.55e-1)" "unprognostic (1.78e-1)" "unprognostic (6.31e-2)" "unprognostic (3.41e-1)" "unprognostic (1.00e-2)" "unprognostic (3.32e-1)" "unprognostic (7.10e-2)" "unprognostic (3.99e-1)" "unprognostic (5.80e-2)" "unprognostic (4.76e-3)" "unprognostic (2.08e-2)" 26.7 39.4 22.7 20.4 34.4 31.0 21.5 29.7 47.8 21.6 23.4 29.8 19.1 19.1 27.6 27.2 25.0 21.3 23.7 41.0 22.1 19.3 28.8 47.1 23.6 21.2 22.9 25.6 35.3 25.7 31.2 26.0 17.8 38.8 27.2 22.4 29.2 25.1 23.8 62.0 28.0 25.3 26.3 19.1 18.9 21.6 41.6 20.4 48.6 28.7 33.0 26.8 26.0 22.4 11.5 13.7 6.0 13.9 12.4 13.9 9.1 25.4 20.6 8.2 11.1 23.3 25.3 9.4 37.8 17.6 30.2 16.5 18.6 15.6 12.8 13.2 23.6 19.7 13.1 29.2 22.8 22.1 18.7 18.1 16.9 13.9 13.3 7.0 21.6 20.8 21.7 33.0 18.9 31.4 18.3 16.9 39.9 22.0 17.6 7.3 5.6 25.1 8.7 11.4 18.2 24.0 19.5 10.5 6.4 28.6 21.0 15.9 24.4 8.4 38.5 23.9 6.7 58.4 18.1 13.6 14.2 13.3 36.5 12.9 11.7 6.0 9.4 4.9 13.1 12.0 12.9 11.5 11.3 12.2 13.7 6.8 12.1 13.9 1.4 12.4 13.9 7.6 13.8 9.1 22.7 34.4 29.7 47.8 22.1 19.3 22.9 25.6 38.8 20.4 PLAT ENSG00000104368 "Plasminogen activator, tissue type" P00750 8 42175233-42207724 "Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins" "Plasminogen activation" "Hydrolase, Protease, Serine protease" "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "parathyroid gland: 132.2" "Cell line enhanced" "Detected in many" "CAPAN-2: 85.8;HMC-1: 55.1;LHCN-M2: 55.6;U-2197: 58.0;WM-115: 115.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Cell type enhanced" "Detected in some" "memory CD4 T-cell: 2.1;T-reg: 2.3" "Group enriched" "Detected in many" 7 "granulocytes: 1.6;T-cells: 2.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA003412, CAB009335" Supported Approved "Actin filaments" "Secreted to blood" 9900000 12000 "Actin filaments" "CAB009335: AB_2237146, HPA003412: AB_1858205" "prognostic favourable (7.57e-4)" "unprognostic (2.23e-1)" "unprognostic (4.08e-1)" "unprognostic (3.39e-1)" "unprognostic (4.88e-3)" "unprognostic (9.39e-2)" "unprognostic (4.65e-3)" "unprognostic (5.78e-2)" "unprognostic (1.55e-1)" "unprognostic (1.75e-1)" "unprognostic (2.98e-3)" "unprognostic (2.46e-1)" "prognostic unfavourable (4.95e-4)" "unprognostic (8.72e-3)" "unprognostic (1.37e-2)" "unprognostic (2.63e-2)" "unprognostic (6.09e-2)" 19.3 14.9 5.2 12.9 6.8 0.4 13.3 2.2 6.2 24.5 17.1 9.1 19.0 11.2 35.5 28.1 18.1 19.1 18.5 7.3 6.0 5.9 67.6 2.8 15.9 1.9 8.2 3.6 18.4 5.8 132.2 5.1 15.5 9.4 27.4 12.2 39.4 6.1 12.7 5.8 2.0 31.7 23.0 7.0 1.0 14.6 12.2 3.8 0.6 11.2 14.7 7.4 47.9 13.7 0.3 0.1 1.6 0.0 0.0 2.3 0.3 0.5 0.2 4.2 1.0 7.7 10.5 0.1 18.0 32.0 7.7 6.6 0.2 85.8 0.0 0.6 2.3 1.4 0.0 4.0 15.9 7.8 1.4 0.1 0.1 0.1 37.9 0.0 55.1 10.5 0.0 18.8 0.7 14.4 0.5 0.1 55.6 0.0 0.0 0.0 5.6 7.6 0.0 15.6 0.0 2.5 0.0 0.0 0.9 0.0 0.1 24.5 0.1 0.0 27.5 1.5 5.7 58.0 1.8 0.0 0.1 0.0 1.2 0.0 115.3 1.6 0.0 0.0 0.3 0.0 1.0 0.3 2.1 0.5 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.1 2.3 0.3 5.2 6.8 2.2 6.2 6.0 5.9 8.2 3.6 9.4 3.8 PLAU "UPA, URK" ENSG00000122861 "Plasminogen activator, urokinase" P00749 10 73909177-73917497 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Blood coagulation, Fibrinolysis, Hemostasis, Plasminogen activation" "Hydrolase, Protease, Serine protease" "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "placenta: 48.4" "Cell line enhanced" "Detected in many" "CAPAN-2: 68.9;LHCN-M2: 66.5;RPTEC TERT1: 252.9;U-251 MG: 67.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 9 "myeloid DC: 2.4;neutrophil: 4.5;plasmacytoid DC: 4.5" "Group enriched" "Detected in many" 11 "dendritic cells: 4.5;granulocytes: 4.5" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" HPA008719 Approved "Secreted to blood" 647333 58000 "HPA008719: AB_1858635" "unprognostic (1.96e-2)" "unprognostic (2.99e-2)" "unprognostic (7.40e-2)" "prognostic favourable (3.38e-4)" "unprognostic (4.73e-2)" "prognostic unfavourable (2.70e-4)" "unprognostic (1.39e-2)" "prognostic unfavourable (4.04e-4)" "unprognostic (2.26e-1)" "unprognostic (6.58e-2)" "prognostic unfavourable (1.32e-4)" "unprognostic (1.61e-1)" "prognostic unfavourable (3.51e-4)" "unprognostic (2.83e-1)" "unprognostic (3.37e-2)" "unprognostic (1.51e-2)" "unprognostic (1.77e-2)" 26.7 2.4 1.0 15.5 2.1 11.3 9.7 1.6 1.5 6.9 5.8 2.9 4.9 3.8 10.7 21.2 9.1 6.5 10.7 14.3 1.3 1.0 23.3 2.3 23.4 5.5 1.6 1.5 6.8 3.7 3.6 1.8 48.4 3.1 7.5 6.7 4.5 10.6 5.0 12.2 9.0 8.1 8.4 2.5 23.8 7.8 5.8 1.3 4.8 10.9 11.6 8.2 16.3 9.3 0.1 4.5 4.5 0.4 0.0 0.0 0.3 13.0 7.0 3.0 0.1 0.2 5.0 0.1 7.9 37.2 3.2 5.1 0.1 68.9 0.0 14.7 1.1 9.0 0.0 13.3 3.7 0.7 0.0 0.0 0.3 0.1 6.1 1.1 2.6 13.3 1.6 22.2 8.6 9.2 0.0 0.0 66.5 0.0 0.0 1.7 0.8 18.3 0.0 9.0 0.0 252.9 10.3 0.0 0.0 0.0 0.3 0.2 0.0 1.8 23.3 0.2 1.6 1.7 67.9 0.0 0.1 0.1 17.9 1.9 0.0 0.0 0.4 0.0 0.0 0.1 0.0 0.1 0.0 0.0 2.4 0.0 0.0 0.0 4.5 0.0 0.0 4.5 0.0 0.3 1.0 2.1 1.6 1.5 1.3 1.0 1.6 1.5 3.1 1.3 PLG ENSG00000122194 Plasminogen P00747 6 160702238-160753315 "Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins" "Blood coagulation, Fibrinolysis, Hemostasis, Tissue remodeling" "Hydrolase, Protease, Serine protease" "Cancer-related genes, Disease mutation, FDA approved drug targets, Thrombophilia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 11 "liver: 269.9" "Cell line enhanced" "Detected in some" "HL-60: 3.5;RH-30: 3.9;U-698: 2.0;U-937: 1.6" "Cancer enriched" "Detected in some" 84 "liver cancer: 180.7" "Not detected" "Not detected" "Not detected" "Not detected" "CAB000668, CAB016678, HPA021602, HPA048823" Supported "Secreted to blood" 140000000000 41000000000 "CAB000668: , CAB016678: AB_1621208, HPA021602: AB_1855453, HPA048823: " "unprognostic (1.70e-1)" "unprognostic (2.16e-3)" "unprognostic (2.44e-1)" "unprognostic (8.54e-3)" "unprognostic (1.41e-1)" "unprognostic (1.76e-3)" "unprognostic (6.28e-2)" "unprognostic (7.25e-2)" "prognostic favourable (4.22e-4)" "unprognostic (3.97e-3)" "unprognostic (5.21e-2)" "unprognostic (2.33e-2)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 24.0 269.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.5 0.0 3.5 0.6 0.0 0.0 0.0 0.0 0.0 0.9 0.4 0.0 0.0 0.3 0.2 0.8 0.0 0.4 3.9 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.5 0.0 0.1 0.0 0.0 1.0 0.0 2.0 0.0 1.6 0.0 0.5 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 PM20D1 "Cps1, FLJ32569" ENSG00000162877 "Peptidase M20 domain containing 1" Q6GTS8 1 205828022-205850132 "Enzymes, Predicted secreted proteins" "Hydrolase, Lyase, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 7 "pancreas: 103.5" "Cell line enriched" "Detected in single" 9 "Karpas-707: 6.4" "Cancer enriched" "Detected in some" 32 "urothelial cancer: 30.2" "Not detected" "Not detected" "Cell type enhanced" "Detected in some" "T-reg: 4.5" "Lineage enriched" "Detected in single" 5 "T-cells: 4.5" "Low region specificity" "Detected in all" "Secreted to digestive system" 3000000 "unprognostic (1.16e-1)" "unprognostic (1.95e-1)" "unprognostic (1.30e-1)" "unprognostic (4.07e-2)" "unprognostic (4.83e-1)" "unprognostic (4.08e-3)" "unprognostic (1.17e-3)" "unprognostic (3.11e-1)" "unprognostic (1.20e-1)" "unprognostic (5.50e-2)" "unprognostic (5.81e-2)" "unprognostic (4.57e-2)" "unprognostic (7.79e-3)" "unprognostic (9.77e-2)" "unprognostic (1.45e-1)" "unprognostic (2.48e-1)" "unprognostic (1.68e-2)" 0.5 0.0 0.0 0.5 0.2 0.0 0.6 0.1 0.4 0.0 0.2 0.6 0.4 0.0 0.2 0.3 0.0 0.1 0.0 0.3 0.3 0.0 3.2 0.1 0.2 0.5 0.2 0.0 0.3 103.5 0.0 0.0 0.1 0.4 0.8 0.0 0.3 0.2 0.4 0.0 14.3 0.1 0.1 0.1 0.4 1.2 0.2 0.1 0.1 0.1 0.1 0.4 1.5 0.3 0.3 0.0 0.8 0.2 0.0 4.5 1.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.2 0.0 0.8 0.7 0.0 1.3 0.3 0.9 2.4 0.0 0.2 0.3 0.9 0.0 0.0 0.2 0.0 4.5 1.0 0.0 0.2 0.1 0.4 0.3 0.0 0.2 0.0 0.4 0.1 PM20D2 "ACY1L2, bA63L7.3" ENSG00000146281 "Peptidase M20 domain containing 2" Q8IYS1 6 89146050-89165565 "Enzymes, Predicted intracellular proteins" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell line enhanced" "Detected in many" "Daudi: 34.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA030325, HPA030326, HPA030327" Approved Enhanced Nucleoplasm Nucleoplasm "HPA030325: , HPA030326: , HPA030327: AB_10603129" "unprognostic (3.60e-2)" "unprognostic (1.40e-1)" "unprognostic (6.36e-2)" "unprognostic (3.18e-3)" "unprognostic (3.22e-2)" "unprognostic (2.73e-1)" "unprognostic (1.13e-3)" "unprognostic (8.60e-2)" "unprognostic (1.04e-1)" "unprognostic (5.86e-2)" "unprognostic (2.27e-2)" "unprognostic (1.04e-1)" "unprognostic (9.99e-2)" "unprognostic (6.84e-2)" "unprognostic (1.28e-1)" "unprognostic (1.32e-1)" "unprognostic (1.31e-1)" 6.8 5.0 4.8 11.4 6.9 6.5 7.6 11.2 4.9 11.9 13.4 4.4 9.3 7.0 11.3 7.1 14.2 11.0 9.1 16.9 5.1 5.5 9.6 9.7 6.2 8.3 3.7 3.1 21.0 11.3 12.5 23.8 6.9 8.6 23.5 8.5 17.6 8.6 8.7 38.5 10.2 8.0 27.7 4.8 5.2 7.6 4.0 2.9 16.6 23.0 10.6 12.1 19.5 8.5 4.1 2.4 3.0 1.0 4.8 4.0 1.5 11.6 5.2 4.7 7.3 1.5 1.0 0.3 5.9 5.9 8.8 11.3 6.1 5.7 34.1 7.2 1.3 4.5 9.5 4.7 20.1 10.5 12.2 6.9 3.2 5.7 1.7 19.8 5.5 1.5 3.5 3.3 7.1 2.1 2.6 18.3 2.7 1.8 12.4 15.7 1.9 5.2 20.7 23.3 24.7 9.9 2.2 13.2 9.2 3.5 5.7 5.8 0.0 17.5 3.4 0.2 5.3 1.8 12.3 9.7 14.2 7.3 2.4 17.1 0.8 1.9 1.0 2.9 2.2 0.6 3.5 4.1 2.7 3.7 1.6 3.1 4.0 3.5 3.0 4.8 0.6 2.4 0.5 1.5 4.8 6.9 11.2 3.9 5.1 5.5 3.7 3.1 8.6 2.9 PMPCA "Alpha-MPP, INPP5E, KIAA0123" ENSG00000165688 "Peptidase, mitochondrial processing alpha subunit" Q10713 9 136410570-136423761 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" "Disease mutation, Mental retardation, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA021648, HPA063735" Supported Enhanced Mitochondria 6500 Mitochondria "HPA021648: AB_1855491, HPA063735: AB_2685108" "unprognostic (9.80e-2)" "unprognostic (1.96e-2)" "unprognostic (4.03e-1)" "unprognostic (1.69e-2)" "unprognostic (4.01e-2)" "unprognostic (8.19e-2)" "unprognostic (6.09e-2)" "unprognostic (1.19e-2)" "unprognostic (1.97e-1)" "unprognostic (3.32e-2)" "prognostic favourable (8.00e-5)" "unprognostic (9.47e-3)" "prognostic favourable (2.14e-6)" "unprognostic (4.27e-3)" "unprognostic (1.57e-2)" "unprognostic (2.40e-1)" "unprognostic (3.54e-2)" 15.2 27.3 19.8 14.6 23.8 20.1 13.2 20.3 24.3 12.3 15.1 13.0 10.4 18.6 14.2 14.1 16.5 13.6 14.9 37.0 15.6 14.8 17.0 48.3 12.3 18.4 15.2 21.9 15.5 18.2 14.7 19.5 15.6 16.8 15.2 11.9 12.8 20.3 17.1 56.7 17.5 17.0 13.8 14.1 18.9 16.3 23.2 12.5 14.0 15.0 19.8 15.3 13.1 13.4 25.5 30.1 17.0 25.1 32.1 30.8 28.2 14.3 26.9 12.9 26.0 9.8 14.3 19.8 15.0 12.1 21.0 15.3 30.7 17.2 20.1 15.8 15.2 33.6 23.8 22.0 9.3 28.9 28.8 16.2 34.7 37.1 17.3 21.0 14.1 21.0 15.2 16.3 8.4 17.7 41.0 13.3 13.0 39.8 19.8 27.1 26.3 25.5 24.7 18.3 44.5 14.4 10.3 26.5 17.4 20.2 28.8 17.5 39.2 28.7 14.6 15.0 16.1 12.3 19.0 8.2 10.9 21.7 19.7 18.4 13.4 15.4 25.1 17.0 27.2 24.4 26.4 25.5 25.7 29.3 30.1 23.7 30.8 26.9 5.9 32.1 23.2 15.3 24.3 28.2 19.8 23.8 20.3 24.3 15.6 14.8 15.2 21.9 16.8 12.5 PMPCB "MPPB, MPPP52" ENSG00000105819 "Peptidase, mitochondrial processing beta subunit" O75439 7 103297422-103329511 "Enzymes, Predicted intracellular proteins" "Hydrolase, Metalloprotease, Protease" "Disease mutation, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA040674, HPA074168" Approved Enhanced Mitochondria 57000 Mitochondria "HPA040674: AB_10961998, HPA074168: " "prognostic favourable (2.79e-4)" "unprognostic (3.11e-1)" "unprognostic (7.18e-3)" "unprognostic (3.03e-1)" "unprognostic (3.65e-2)" "unprognostic (1.72e-1)" "unprognostic (1.06e-1)" "unprognostic (7.67e-2)" "unprognostic (7.74e-2)" "unprognostic (1.21e-1)" "unprognostic (1.38e-1)" "unprognostic (1.42e-3)" "prognostic favourable (2.95e-8)" "unprognostic (2.59e-2)" "unprognostic (9.79e-2)" "unprognostic (2.40e-1)" "unprognostic (4.39e-2)" 29.1 41.8 31.8 23.0 34.3 41.5 31.6 41.1 38.4 29.0 26.9 21.6 28.2 35.1 32.0 25.9 27.9 26.9 23.5 41.4 27.7 20.1 45.9 47.2 21.9 31.3 32.6 35.0 36.8 40.6 41.1 33.9 24.8 34.2 31.6 31.5 20.8 30.6 31.0 31.5 31.6 31.0 25.7 27.8 27.9 33.6 31.3 35.9 37.2 33.2 24.2 30.0 30.7 27.9 19.5 18.4 9.7 16.1 12.9 21.9 15.7 12.1 17.6 20.8 27.9 12.6 25.6 15.7 11.3 19.5 22.9 27.3 18.8 14.0 31.3 18.2 19.3 15.8 24.9 18.2 21.9 10.9 29.7 10.8 30.2 25.0 15.4 14.8 12.8 23.4 17.0 17.9 17.3 12.1 20.9 31.8 20.9 28.3 24.6 35.0 25.4 22.1 17.2 14.5 31.8 21.5 21.8 26.1 31.9 15.3 45.2 22.3 18.5 19.9 10.0 20.3 24.3 36.0 21.0 24.4 31.2 24.0 15.0 24.0 15.9 9.7 14.1 9.3 14.7 16.1 16.1 19.5 17.1 14.7 18.4 14.3 21.5 17.4 4.4 12.9 13.6 9.4 21.9 15.7 31.8 34.3 41.1 38.4 27.7 20.1 32.6 35.0 34.2 35.9 PRCP "HUMPCP, PCP" ENSG00000137509 Prolylcarboxypeptidase P42785 11 82823502-82970584 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Carboxypeptidase, Hydrolase, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell line enhanced" "Detected in all" "ASC diff: 97.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA017065, HPA071115" Approved Supported Vesicles "Intracellular and membrane" 34000000 Vesicles "HPA017065: AB_1855676, HPA071115: " "unprognostic (3.24e-1)" "unprognostic (2.25e-1)" "unprognostic (1.76e-1)" "unprognostic (1.51e-1)" "unprognostic (2.54e-1)" "unprognostic (1.33e-2)" "unprognostic (9.22e-2)" "unprognostic (1.42e-1)" "unprognostic (7.97e-2)" "unprognostic (2.61e-1)" "unprognostic (2.70e-1)" "unprognostic (1.88e-2)" "prognostic favourable (2.65e-6)" "unprognostic (7.16e-2)" "unprognostic (1.73e-2)" "unprognostic (3.49e-1)" "unprognostic (4.07e-1)" 32.6 45.9 25.0 21.5 22.2 13.1 69.5 19.4 23.8 38.8 17.9 17.9 27.6 11.0 30.7 35.5 32.2 24.6 25.6 66.3 25.8 18.9 52.4 52.5 38.1 95.1 27.0 14.8 27.8 23.4 30.6 19.3 59.8 34.9 25.1 18.4 25.1 38.1 34.5 10.3 26.2 15.7 32.8 45.0 25.1 16.8 17.4 17.7 9.8 27.9 24.2 31.7 39.4 30.1 13.1 50.0 31.2 27.9 12.1 6.2 14.7 7.5 8.2 12.6 25.4 97.9 35.9 14.8 16.0 28.6 15.4 22.5 20.3 15.5 10.8 23.4 23.2 11.9 11.5 10.5 18.0 9.6 8.3 7.7 11.4 12.6 18.3 6.9 28.2 26.2 8.3 16.0 15.2 50.8 8.3 15.2 15.7 3.4 1.0 24.7 7.3 7.7 5.6 21.9 12.9 21.5 13.8 5.3 11.5 21.9 12.7 9.0 15.2 9.5 13.2 18.1 18.1 15.6 7.8 14.3 24.4 9.6 7.4 8.4 9.3 15.5 26.4 17.4 5.3 27.9 6.1 9.9 5.3 5.8 50.0 13.1 4.4 6.2 31.2 12.1 21.2 8.9 5.0 14.7 25.0 22.2 19.4 23.8 25.8 18.9 27.0 14.8 34.9 17.7 PREP ENSG00000085377 "Prolyl endopeptidase" P48147 6 105277565-105403084 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB025414, HPA031388, HPA031389, HPA031390" Supported Supported Cytosol 1400000 Cytosol "CAB025414: , HPA031388: , HPA031389: , HPA031390: " "unprognostic (3.05e-2)" "unprognostic (9.09e-3)" "unprognostic (2.85e-2)" "unprognostic (5.46e-2)" "unprognostic (3.36e-1)" "prognostic unfavourable (3.33e-4)" "unprognostic (2.63e-3)" "unprognostic (2.39e-1)" "unprognostic (6.78e-2)" "unprognostic (5.81e-2)" "unprognostic (2.66e-2)" "unprognostic (1.15e-1)" "unprognostic (4.47e-3)" "unprognostic (2.74e-2)" "unprognostic (8.98e-2)" "unprognostic (6.59e-2)" "unprognostic (2.33e-1)" 13.0 14.2 10.1 22.2 10.1 10.4 36.2 10.9 24.9 11.9 27.2 5.2 11.2 20.2 13.2 10.9 16.4 10.5 15.0 19.0 8.8 7.1 8.9 14.6 23.9 31.4 8.3 15.4 13.6 18.8 16.1 11.1 15.4 9.7 9.4 33.0 8.9 14.9 11.5 58.0 24.2 19.0 15.3 8.5 11.9 14.0 20.1 8.8 17.4 10.2 18.5 13.3 18.2 21.0 8.3 15.3 7.1 18.7 16.6 16.3 11.2 10.8 13.3 14.2 15.9 33.6 19.9 14.0 14.6 13.7 19.3 20.5 16.9 6.9 13.9 14.4 17.1 16.9 20.9 42.8 22.0 21.0 20.4 18.7 11.2 19.2 13.0 18.8 13.7 18.5 26.1 13.9 35.8 18.0 31.8 24.9 23.3 17.6 12.5 19.1 13.7 13.3 19.4 24.5 9.1 14.4 25.9 18.6 26.5 12.8 21.5 10.2 9.2 30.2 18.1 8.9 12.3 11.1 17.9 7.3 4.8 18.2 15.7 20.5 27.6 4.8 13.6 7.1 16.0 15.4 15.6 8.3 13.7 16.3 15.3 6.8 12.9 15.2 0.7 16.6 18.7 6.5 12.0 11.2 10.1 10.1 10.9 24.9 8.8 7.1 8.3 15.4 9.7 8.8 PREPL KIAA0436 ENSG00000138078 "Prolyl endopeptidase like" Q4J6C6 2 44316281-44361862 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" "Hydrolase, Protease, Serine protease" "Congenital myasthenic syndrome, Disease mutation" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 78.4" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA063238 Approved "HPA063238: " "unprognostic (5.60e-3)" "unprognostic (9.81e-2)" "unprognostic (4.51e-2)" "unprognostic (4.65e-3)" "unprognostic (2.22e-1)" "unprognostic (8.53e-2)" "unprognostic (5.98e-3)" "unprognostic (4.38e-3)" "unprognostic (2.27e-1)" "unprognostic (2.72e-2)" "unprognostic (1.52e-2)" "unprognostic (4.67e-2)" "unprognostic (2.33e-2)" "unprognostic (3.79e-1)" "unprognostic (1.87e-1)" "unprognostic (1.76e-1)" "unprognostic (1.75e-1)" 11.5 24.5 32.6 8.2 78.4 2.5 15.0 57.3 75.8 18.1 11.3 18.7 6.0 12.0 22.1 34.2 10.9 16.4 13.4 28.2 51.8 50.2 30.4 9.9 11.4 7.6 28.5 44.0 24.3 11.6 34.9 33.2 9.9 69.4 18.1 14.1 13.0 11.7 16.5 13.7 10.2 12.6 16.3 31.3 10.5 12.1 12.6 21.5 5.2 28.9 7.1 8.2 10.7 10.3 8.8 6.3 4.7 4.8 11.1 12.5 5.8 18.3 14.1 16.3 20.7 26.5 27.8 12.5 20.7 15.7 14.9 12.9 15.3 13.0 23.6 28.7 21.5 15.9 23.5 15.0 28.7 21.6 16.6 16.5 11.3 11.6 19.2 15.6 15.2 17.9 30.0 28.7 23.3 14.3 20.2 34.3 19.9 9.8 17.1 7.6 15.7 16.1 13.5 19.9 16.8 28.5 10.7 28.1 21.8 13.5 14.2 29.9 19.0 12.4 15.0 26.5 15.0 20.7 14.0 18.9 12.4 15.5 31.0 18.6 19.5 4.7 4.5 3.4 8.5 4.8 12.2 8.8 8.1 9.2 6.3 7.4 12.5 9.7 1.3 11.1 4.1 3.1 8.7 5.8 32.6 78.4 57.3 75.8 51.8 50.2 28.5 44.0 69.4 21.5 PROC ENSG00000115718 "Protein C, inactivator of coagulation factors Va and VIIIa" P04070 2 127418427-127429246 "Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Blood coagulation, Hemostasis" "Hydrolase, Protease, Serine protease" "Cancer-related genes, Disease mutation, FDA approved drug targets, Thrombophilia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 5 "liver: 137.5" "Cell line enriched" "Detected in some" 16 "Hep G2: 57.5" "Cancer enriched" "Detected in many" 22 "liver cancer: 118.3" "Not detected" "Not detected" "Cell type enriched" "Detected in some" 9 "plasmacytoid DC: 29.2" "Lineage enriched" "Detected in many" 9 "dendritic cells: 29.2" "Not detected" "Not detected" "Not detected" "Not detected" "HPA005550, CAB016721, CAB016792" Supported "Secreted to blood" 6400000000 "CAB016721: , CAB016792: , HPA005550: AB_1079687" "unprognostic (2.46e-2)" "unprognostic (1.08e-1)" "unprognostic (1.38e-1)" "unprognostic (1.58e-1)" "unprognostic (6.64e-2)" "unprognostic (3.13e-2)" "unprognostic (4.90e-3)" "unprognostic (2.63e-1)" "unprognostic (1.67e-1)" "unprognostic (3.29e-1)" "unprognostic (3.74e-3)" "unprognostic (2.56e-2)" "unprognostic (8.12e-3)" "unprognostic (2.01e-2)" "unprognostic (1.71e-1)" "unprognostic (4.60e-3)" "unprognostic (8.06e-2)" 0.0 0.0 0.4 0.1 0.1 0.2 0.0 0.1 0.2 0.1 0.2 0.0 0.1 0.2 0.0 0.1 0.0 0.0 0.6 0.0 0.4 0.2 4.2 137.5 0.2 0.1 0.1 0.1 0.0 0.0 0.0 0.0 0.1 0.4 0.1 0.1 0.0 0.0 0.1 0.0 0.1 0.5 0.0 0.1 0.0 0.6 0.0 0.0 0.7 0.0 0.0 0.1 0.1 0.0 0.4 29.2 3.1 0.0 0.0 0.0 0.1 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 1.5 0.0 0.3 0.0 3.6 0.0 0.1 0.0 0.0 0.0 0.0 2.7 57.5 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.6 0.1 0.2 0.0 0.0 0.0 0.0 0.3 0.1 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.1 0.0 0.0 0.0 3.1 0.0 0.0 29.2 0.0 0.1 0.4 0.1 0.1 0.2 0.4 0.2 0.1 0.1 0.4 0.0 PROZ PZ ENSG00000126231 "Protein Z, vitamin K dependent plasma glycoprotein" P22891 13 113158654-113172383 "Candidate cardiovascular disease genes, Enzymes, Plasma proteins, Predicted secreted proteins" "Blood coagulation, Hemostasis" "Serine protease homolog" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 5 "liver: 45.0" "Cell line enhanced" "Detected in some" "HaCaT: 4.8;Hep G2: 7.6" "Cancer enriched" "Detected in single" 27 "liver cancer: 12.1" "Not detected" "Not detected" "Cell type enhanced" "Detected in some" "intermediate monocyte: 2.7;T-reg: 1.5" "Group enriched" "Detected in many" 12 "monocytes: 2.7;T-cells: 1.5" "Not detected" "Not detected" HPA052006 Supported "Secreted to blood" 1716566667 510000000 "HPA052006: AB_2681691" "unprognostic (5.03e-2)" "unprognostic (4.05e-2)" "unprognostic (1.11e-1)" "unprognostic (2.36e-1)" "unprognostic (6.48e-2)" "unprognostic (1.39e-1)" "prognostic favourable (3.46e-4)" "unprognostic (4.10e-1)" "unprognostic (2.21e-1)" "unprognostic (2.50e-1)" "unprognostic (5.20e-2)" "unprognostic (2.87e-1)" "unprognostic (9.83e-2)" "unprognostic (5.63e-2)" "unprognostic (1.41e-1)" "unprognostic (9.99e-2)" "unprognostic (2.51e-4)" 0.1 0.1 0.1 0.1 0.1 0.0 0.1 0.2 0.1 0.1 0.3 0.1 0.1 0.1 0.1 0.5 0.1 0.0 0.1 0.1 0.1 0.0 9.3 45.0 0.1 0.1 0.1 0.1 0.1 0.2 0.0 0.5 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.1 0.3 0.1 0.1 0.1 0.1 0.1 0.6 0.1 0.1 0.2 0.1 0.1 0.1 0.1 0.0 0.1 0.0 2.7 0.0 1.5 0.2 0.9 1.4 0.7 1.0 0.0 0.0 0.6 1.5 0.0 0.0 0.0 3.0 1.8 0.8 0.0 0.0 4.8 0.0 0.0 0.0 0.8 2.4 1.0 2.8 7.6 0.1 0.8 0.4 0.0 0.0 0.0 0.0 0.0 1.1 0.6 0.0 1.0 0.6 0.8 1.8 0.4 1.3 0.2 0.3 0.0 1.1 2.9 0.2 0.0 0.3 1.3 0.0 1.0 0.7 0.8 0.1 0.8 0.3 1.6 0.9 0.8 1.6 0.9 0.7 0.0 0.0 0.0 0.3 2.7 0.4 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.6 0.1 1.5 0.2 0.1 0.1 0.2 0.1 0.1 0.0 0.1 0.1 0.1 0.1 PRSS1 TRY1 ENSG00000204983 "Serine protease 1" P07477 7 142749468-142753076 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" Digestion "Hydrolase, Protease, Serine protease" "Cancer-related genes, Disease mutation, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 1708 "pancreas: 3057.4" "Cell line enhanced" "Detected in some" "EFO-21: 3.5;HDLM-2: 1.7;RPMI-8226: 6.9;U-2 OS: 4.1;U-251 MG: 1.5;U-266/84: 2.5" "Cancer enriched" "Detected in many" 224 "pancreatic cancer: 1920.3" "Not detected" "Not detected" "Cell type enhanced" "Detected in some" "basophil: 1.7" "Low lineage specificity" "Detected in many" "CAB025487, CAB025538, HPA062452, HPA063471" Enhanced Approved "Endoplasmic reticulum,Vesicles" "Secreted to digestive system" 26000000000 Vesicles "Endoplasmic reticulum" "CAB025487: , CAB025538: , HPA062452: , HPA063471: " "unprognostic (6.55e-5)" "unprognostic (5.28e-1)" "unprognostic (7.58e-2)" "prognostic unfavourable (6.41e-6)" "unprognostic (8.26e-2)" "prognostic favourable (7.05e-4)" "unprognostic (1.35e-1)" "unprognostic (3.93e-2)" "unprognostic (1.96e-1)" "prognostic favourable (4.91e-4)" "unprognostic (3.12e-1)" 0.4 0.0 0.1 0.1 0.1 0.0 0.1 0.1 0.2 0.1 0.1 0.2 0.2 0.2 0.2 0.1 0.1 0.0 0.1 0.4 0.1 0.0 0.1 0.1 0.1 0.1 0.1 0.1 1.6 3057.4 0.0 0.1 0.1 0.1 0.2 0.0 0.1 0.4 0.2 0.1 0.0 0.4 0.1 0.1 0.1 0.5 0.2 0.1 0.1 0.1 0.1 0.1 0.1 0.1 1.0 0.0 1.7 0.0 0.0 0.9 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 3.5 0.0 0.0 0.0 0.0 0.0 1.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 6.9 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.1 0.0 1.5 0.0 2.5 0.6 0.0 0.0 0.0 1.7 0.0 0.0 0.0 0.0 0.0 1.0 0.9 0.0 0.0 0.8 0.3 0.0 0.0 0.0 0.0 0.0 0.6 0.1 0.1 0.1 0.1 0.2 0.1 0.0 0.1 0.1 0.1 0.1 PRSS12 "BSSP-3, MRT1" ENSG00000164099 "Serine protease 12" P56730 4 118280038-118353003 "Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Mental retardation" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "gallbladder: 27.5;testis: 31.3" "Cell line enhanced" "Detected in many" "fHDF/TERT166: 20.4;SH-SY5Y: 64.8;THP-1: 29.0" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in many" 5 "amygdala: 11.6;basal ganglia: 8.7;cerebral cortex: 26.5;hippocampal formation: 15.3;olfactory region: 11.0" "Low region specificity" "Detected in all" HPA035054 Uncertain Approved "Nucleoplasm,Actin filaments" "Secreted - unknown location" "Actin filaments" Nucleoplasm "HPA035054: AB_10603990" "unprognostic (4.30e-2)" "unprognostic (1.04e-2)" "unprognostic (2.55e-1)" "unprognostic (4.41e-2)" "prognostic favourable (2.66e-4)" "prognostic favourable (1.03e-4)" "unprognostic (4.21e-1)" "unprognostic (3.48e-2)" "unprognostic (7.83e-2)" "unprognostic (6.38e-2)" "unprognostic (1.09e-1)" "unprognostic (1.27e-1)" "unprognostic (2.41e-2)" "unprognostic (1.29e-1)" "unprognostic (1.85e-1)" "unprognostic (9.55e-2)" "unprognostic (1.09e-1)" 0.9 0.5 2.1 4.1 1.4 0.0 1.9 0.5 2.8 16.5 6.0 2.0 1.3 2.2 3.0 2.7 3.6 9.8 27.5 0.3 2.2 0.9 1.1 0.8 8.0 0.0 0.7 2.4 1.9 9.8 0.0 0.9 20.4 4.1 2.0 5.8 20.0 3.1 3.2 0.3 5.9 8.6 1.0 0.5 0.3 8.1 31.3 0.2 0.3 0.6 7.7 7.7 3.1 16.2 0.3 0.4 0.0 0.1 0.0 0.7 0.0 1.4 0.0 0.5 0.0 0.0 4.1 0.0 13.5 12.2 2.9 4.8 0.0 5.5 0.0 0.0 20.4 0.2 9.1 2.7 3.8 0.0 2.1 0.0 1.1 0.0 0.4 0.0 0.0 1.2 5.2 1.0 3.0 0.0 0.0 0.0 2.3 0.0 0.1 2.7 0.6 0.8 0.0 11.5 0.0 0.0 2.0 1.5 64.8 0.0 0.0 0.8 0.0 29.0 0.0 5.8 0.8 3.6 2.6 0.3 0.0 0.0 0.3 0.9 3.3 0.0 0.1 0.0 0.0 0.1 0.7 0.3 0.0 0.0 0.4 0.3 0.4 0.2 0.0 0.0 0.0 0.2 0.0 0.0 2.1 1.4 0.5 2.8 2.2 0.9 0.7 2.4 4.1 0.2 PRSS16 TSSP ENSG00000112812 "Serine protease 16" Q9NQE7 6 27247701-27256624 "Enzymes, Predicted intracellular proteins, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Tissue enriched" "Detected in many" 14 "lymphoid tissue: 242.8" "Cell line enhanced" "Detected in some" "hTCEpi: 19.5;RPMI-8226: 10.5" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Cell type enhanced" "Detected in some" "memory B-cell: 5.4" "Group enriched" "Detected in many" 39 "B-cells: 5.4;T-cells: 2.3" "Low region specificity" "Detected in single" "Low region specificity" "Detected in all" "Secreted in other tissues" "unprognostic (1.50e-1)" "unprognostic (6.95e-2)" "unprognostic (1.91e-2)" "unprognostic (1.51e-1)" "unprognostic (2.21e-2)" "unprognostic (1.74e-2)" "unprognostic (9.21e-3)" "unprognostic (1.57e-1)" "unprognostic (7.89e-2)" "prognostic favourable (6.46e-5)" "unprognostic (1.57e-1)" "unprognostic (3.49e-2)" "unprognostic (5.42e-2)" "unprognostic (1.95e-1)" "unprognostic (5.49e-2)" "unprognostic (2.10e-1)" "unprognostic (1.62e-2)" 0.9 0.5 0.9 0.9 0.9 0.0 3.6 0.9 0.9 2.0 3.3 0.9 0.9 2.3 0.9 9.3 3.6 3.3 2.1 0.9 0.9 0.0 1.4 0.9 2.4 0.9 0.9 0.9 1.2 17.1 6.4 1.8 2.1 0.9 1.8 4.1 0.9 4.3 2.5 0.9 2.9 2.8 0.9 0.9 0.9 3.9 0.9 0.9 242.8 8.7 0.9 0.9 2.0 1.1 5.4 0.0 0.0 0.0 0.0 2.3 0.4 2.9 0.2 0.0 0.0 0.0 0.0 4.0 0.0 0.0 0.0 0.1 3.4 4.5 0.0 0.7 0.0 1.5 2.5 3.0 0.0 0.1 0.4 0.0 0.0 0.0 0.0 1.9 0.5 0.0 19.5 0.0 4.0 0.0 2.2 1.8 0.0 1.1 0.4 0.0 0.6 0.5 0.0 0.0 10.5 2.3 3.4 0.0 0.0 1.3 3.0 0.0 1.9 0.8 0.0 0.0 0.7 0.0 0.0 0.7 1.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 1.8 0.0 2.0 5.4 2.3 1.0 0.0 0.5 0.0 0.2 0.0 0.0 0.0 0.0 0.5 0.4 0.9 0.9 0.9 0.9 0.9 0.0 0.9 0.9 0.9 0.9 PRSS2 TRY2 ENSG00000275896 "Serine protease 2" P07478 7 142760398-142774564 "Enzymes, Plasma proteins, Predicted secreted proteins" Digestion "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 708 "pancreas: 6267.9" "Cell line enriched" "Detected in some" 5 "RPMI-8226: 37.2" "Cancer enriched" "Detected in many" 72 "pancreatic cancer: 3463.4" "Group enriched" "Detected in some" 6 "basophil: 5.6;T-reg: 5.1" "Group enriched" "Detected in many" 6 "granulocytes: 5.6;T-cells: 5.1" "HPA062452, HPA063471" Supported Approved "Endoplasmic reticulum,Vesicles" "Secreted to digestive system" 27000000000 Vesicles "Endoplasmic reticulum" "HPA062452: , HPA063471: " "prognostic favourable (2.32e-4)" "unprognostic (3.80e-1)" "unprognostic (2.46e-1)" "unprognostic (3.30e-3)" "unprognostic (1.99e-2)" "unprognostic (3.06e-2)" "unprognostic (1.36e-1)" "unprognostic (4.62e-3)" "unprognostic (1.48e-1)" "unprognostic (4.65e-2)" "unprognostic (1.55e-3)" "unprognostic (1.58e-2)" "unprognostic (3.50e-1)" "unprognostic (5.36e-3)" "unprognostic (1.18e-1)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 4.1 0.0 0.0 3.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 6267.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 8.8 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 5.6 0.0 0.7 5.1 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.2 0.0 0.0 0.0 0.0 0.0 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 2.4 0.2 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 37.2 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 8.1 0.5 2.1 0.0 1.6 0.2 0.0 0.0 0.0 5.6 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 5.1 0.3 PRSS21 "ESP-1, TEST1" ENSG00000007038 "Serine protease 21" Q9Y6M0 16 2817180-2826304 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 5 "blood: 21.0;salivary gland: 20.9;testis: 37.5" "Cell line enhanced" "Detected in some" "CAPAN-2: 10.2;HEL: 11.3;HeLa: 29.2;K-562: 13.4;U-698: 41.2" "Cancer enhanced" "Detected in many" "ovarian cancer: 23.9" "Not detected" "Not detected" "Group enriched" "Detected in many" 5 "basophil: 10.5;eosinophil: 21.0" "Lineage enriched" "Detected in many" 6 "granulocytes: 21.0" "Not detected" "Not detected" "Region enriched" "Detected in single" 27 "basal ganglia: 6.7" HPA008477 Enhanced Approved Cytosol "Intracellular and membrane" Cytosol "HPA008477: AB_1079697" "unprognostic (4.35e-2)" "unprognostic (3.46e-2)" "unprognostic (7.06e-2)" "unprognostic (4.28e-3)" "unprognostic (1.19e-3)" "unprognostic (7.02e-2)" "unprognostic (1.22e-1)" "unprognostic (2.61e-2)" "unprognostic (2.33e-1)" "unprognostic (5.21e-2)" "unprognostic (8.83e-3)" "unprognostic (1.52e-3)" "unprognostic (2.97e-2)" "unprognostic (1.14e-2)" "unprognostic (5.07e-2)" "unprognostic (7.79e-2)" "unprognostic (2.99e-1)" 0.8 0.0 0.2 0.2 0.2 5.5 1.0 0.4 0.4 1.4 0.4 0.2 1.4 0.2 0.3 0.2 0.8 2.2 2.1 0.2 0.2 0.0 0.2 0.2 2.1 3.3 0.2 0.2 0.3 0.9 1.7 0.2 0.3 0.4 1.8 0.2 0.2 20.9 0.2 0.5 0.4 0.4 0.2 0.2 0.9 0.4 37.5 0.2 0.9 0.2 1.2 1.1 0.3 0.6 0.8 1.4 21.0 2.3 1.0 3.3 1.3 4.4 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 10.2 0.0 0.0 0.3 0.4 0.0 0.0 0.0 0.0 0.0 11.3 29.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 13.4 0.0 0.0 0.0 0.0 5.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 41.2 0.0 0.0 0.0 10.5 2.3 21.0 2.2 1.6 3.3 0.8 1.1 1.8 0.6 0.6 1.5 2.2 0.2 1.0 0.3 1.4 0.5 1.3 0.2 0.2 0.4 0.4 0.2 0.0 0.2 0.2 0.4 0.2 PRSS22 "BSSP-4, hBSSP-4, SP001LA" ENSG00000005001 "Serine protease 22" Q9GZN4 16 2852727-2858170 "Enzymes, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "esophagus: 40.4;lymphoid tissue: 40.1;tongue: 36.5" "Cell line enhanced" "Detected in some" "CAPAN-2: 2.6;MCF7: 12.4;RT4: 5.8;SK-BR-3: 13.1" "Low cancer specificity" "Detected in many" "Region enriched" "Detected in single" 16 "cerebellum: 1.5" "Not detected" "Not detected" "Not detected" "Not detected" "Region enhanced" "Detected in single" "cerebral cortex: 2.6" "Low region specificity" "Detected in all" HPA049161 Approved Approved Nucleoplasm "Secreted in other tissues" Nucleoplasm "HPA049161: " "unprognostic (1.45e-1)" "unprognostic (9.80e-2)" "unprognostic (3.50e-2)" "unprognostic (4.48e-1)" "unprognostic (2.29e-4)" "unprognostic (2.58e-1)" "unprognostic (4.42e-2)" "unprognostic (1.52e-2)" "unprognostic (5.06e-1)" "unprognostic (7.52e-2)" "unprognostic (3.74e-3)" "unprognostic (4.12e-1)" "unprognostic (2.32e-4)" "unprognostic (1.04e-2)" "unprognostic (1.58e-1)" "unprognostic (1.62e-1)" "unprognostic (2.75e-1)" 0.4 0.7 0.0 0.4 0.0 0.6 1.3 1.5 0.4 9.9 1.0 0.0 8.6 1.5 3.0 0.6 40.4 3.0 6.8 0.4 0.0 0.0 2.4 0.7 3.0 0.4 0.0 0.0 0.4 7.5 0.4 1.1 4.3 0.0 5.1 0.6 0.0 13.4 10.6 2.3 1.3 0.4 0.7 0.0 0.4 3.5 0.4 0.0 0.0 1.5 36.5 40.1 5.2 9.6 0.0 0.0 0.0 0.0 0.0 0.5 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 2.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 12.4 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.8 0.0 0.0 0.0 13.1 0.0 1.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 PRSS23 "SIG13, SPUVE" ENSG00000150687 "Serine protease 23" O95084 11 86791059-86952910 "Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell line enhanced" "Detected in many" "CAPAN-2: 59.0;HUVEC TERT2: 73.6;TIME: 137.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Cell type enhanced" "Detected in many" "gdT-cell: 36.4" "Group enriched" "Detected in many" 30 "NK-cells: 10.2;T-cells: 36.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" HPA030591 Uncertain "Secreted to blood" 290000 "HPA030591: AB_10602067" "unprognostic (2.68e-2)" "unprognostic (1.20e-2)" "unprognostic (1.90e-1)" "unprognostic (2.04e-1)" "unprognostic (2.40e-3)" "prognostic unfavourable (2.12e-4)" "unprognostic (1.89e-2)" "unprognostic (4.30e-2)" "unprognostic (2.08e-1)" "unprognostic (2.09e-1)" "prognostic unfavourable (5.56e-4)" "unprognostic (5.35e-2)" "prognostic unfavourable (3.06e-4)" "unprognostic (5.13e-3)" "unprognostic (9.44e-2)" "unprognostic (1.99e-3)" "unprognostic (8.01e-2)" 19.5 8.7 2.3 10.8 4.1 0.4 40.7 1.2 2.6 89.0 33.8 2.1 37.2 5.1 44.9 27.4 14.5 9.6 45.6 17.2 5.0 3.0 17.5 10.4 36.2 15.9 3.7 4.4 16.2 14.3 9.6 6.3 30.2 12.5 36.7 14.4 15.2 17.6 37.3 19.1 7.2 12.4 100.2 4.9 7.3 22.0 19.5 1.4 3.8 15.3 10.5 5.8 68.6 31.1 0.0 0.0 0.5 0.7 10.2 36.4 10.9 7.3 18.5 19.9 0.1 8.9 21.9 0.0 32.5 29.9 36.3 29.1 42.9 59.0 0.0 25.9 49.8 15.3 0.3 24.8 8.8 0.0 1.5 2.5 9.5 0.1 4.5 0.0 0.1 17.4 3.3 17.7 20.2 73.6 0.1 0.0 27.3 10.1 0.0 0.0 1.2 2.0 0.0 0.0 0.0 13.6 9.9 0.1 0.1 7.2 0.5 2.2 0.7 0.0 137.4 21.7 0.2 43.3 18.4 0.1 0.1 0.0 15.5 0.0 21.4 0.0 0.0 0.0 36.4 0.0 0.0 0.0 6.6 20.5 0.0 0.0 1.8 18.5 0.5 10.2 0.7 0.0 0.0 10.9 2.3 4.1 1.2 2.6 5.0 3.0 3.7 4.4 12.5 1.4 PRSS27 "CAPH2, MPN" ENSG00000172382 "Serine protease 27" Q9BQR3 16 2712418-2720551 "Enzymes, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "esophagus: 94.1;lymphoid tissue: 97.2;tongue: 64.5" "Cell line enhanced" "Detected in some" "BEWO: 5.4;SK-BR-3: 21.8;T-47d: 12.8;U-266/70: 4.5" "Cancer enhanced" "Detected in many" "head and neck cancer: 5.4" "Not detected" "Not detected" "Cell type enhanced" "Detected in some" "memory CD4 T-cell: 1.4;myeloid DC: 1.7" "Group enriched" "Detected in many" 5 "dendritic cells: 1.7;T-cells: 1.4" "Not detected" "Not detected" "Not detected" "Not detected" "CAB024920, HPA028848" Approved Approved Vesicles "Secreted to digestive system" Vesicles "CAB024920: , HPA028848: " "unprognostic (2.10e-2)" "unprognostic (2.15e-1)" "unprognostic (3.46e-3)" "unprognostic (5.35e-2)" "unprognostic (5.25e-2)" "unprognostic (2.48e-2)" "unprognostic (2.56e-1)" "unprognostic (3.12e-1)" "unprognostic (4.66e-1)" "unprognostic (1.08e-1)" "unprognostic (3.79e-2)" "unprognostic (4.40e-3)" "unprognostic (4.03e-3)" "unprognostic (2.40e-1)" "unprognostic (2.26e-1)" "unprognostic (2.04e-2)" "unprognostic (1.28e-2)" 0.2 0.3 0.1 0.2 0.5 0.2 0.4 0.7 0.4 15.3 0.2 0.1 0.1 0.1 1.2 0.1 94.1 0.3 0.2 0.2 0.1 0.4 0.2 0.2 0.2 0.2 0.1 0.1 0.2 0.1 0.5 0.1 0.2 0.1 0.2 0.1 0.1 10.0 0.3 0.2 1.2 0.1 0.2 0.1 0.2 0.1 0.5 0.1 0.3 0.2 64.5 97.2 0.5 24.0 0.1 1.7 0.2 0.0 0.2 1.4 1.2 0.0 0.2 0.5 1.8 0.3 0.6 5.4 0.0 0.2 0.2 0.1 0.0 0.4 0.3 0.1 0.0 0.0 0.0 0.0 0.0 1.8 0.5 0.1 0.1 0.0 0.9 0.0 0.2 1.0 0.0 0.0 0.0 0.0 0.1 0.5 0.0 1.6 0.0 0.9 1.3 0.0 0.8 0.2 0.1 0.1 0.3 0.6 2.6 0.0 21.8 0.5 12.8 1.5 0.0 0.3 0.0 0.0 0.0 4.5 3.1 0.4 0.0 0.1 0.8 0.0 0.0 0.0 0.1 0.0 0.0 0.1 1.4 0.0 1.7 0.0 0.3 0.7 0.2 0.2 0.0 0.0 0.0 1.2 0.1 0.5 0.7 0.1 0.1 0.4 0.1 0.1 0.1 0.1 PRSS3 "PRSS4, TRY3, TRY4" ENSG00000010438 "Serine protease 3" P35030 9 33750466-33799231 "Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" Digestion "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 25 "pancreas: 984.9" "Cell line enriched" "Detected in some" 8 "PC-3: 121.9" "Group enriched" "Detected in many" 7 "colorectal cancer: 72.8;pancreatic cancer: 104.4;stomach cancer: 43.8" "Low region specificity" "Detected in many" "Cell type enriched" "Detected in single" 82 "basophil: 39.0" "Lineage enriched" "Detected in single" 82 "granulocytes: 39.0" "HPA062452, HPA063471" Supported Approved "Endoplasmic reticulum,Vesicles" "Secreted to digestive system" 490000000 Vesicles "Endoplasmic reticulum" "HPA062452: , HPA063471: " "unprognostic (6.90e-2)" "unprognostic (2.26e-1)" "unprognostic (1.69e-2)" "prognostic unfavourable (4.30e-4)" "unprognostic (3.18e-1)" "unprognostic (1.64e-1)" "unprognostic (3.29e-2)" "unprognostic (5.89e-3)" "unprognostic (1.38e-1)" "unprognostic (2.06e-3)" "unprognostic (1.10e-2)" "unprognostic (8.94e-2)" "unprognostic (7.75e-4)" "unprognostic (5.46e-3)" "unprognostic (2.13e-1)" "unprognostic (8.79e-2)" "unprognostic (4.96e-1)" 0.3 0.3 1.6 1.7 1.5 0.2 0.2 2.8 4.2 0.9 8.2 0.0 0.0 2.8 0.2 0.2 2.9 0.2 4.8 0.4 1.2 0.7 0.3 0.4 0.2 0.2 0.3 1.6 0.7 984.9 0.2 0.1 0.2 2.3 0.2 2.3 0.0 0.6 0.2 0.2 2.0 23.9 0.3 0.2 0.2 0.8 0.3 0.0 0.0 0.2 6.6 3.5 0.2 1.3 0.0 0.1 39.0 0.4 0.1 0.3 0.1 1.7 2.0 0.1 0.0 0.0 0.9 0.0 4.8 1.1 0.5 0.2 4.7 0.4 0.0 0.0 2.1 2.1 0.0 4.4 1.4 0.0 0.0 0.0 0.1 0.0 0.4 0.0 0.0 0.0 0.0 1.5 15.9 9.8 0.0 0.0 0.0 0.0 0.1 0.0 0.0 121.9 0.0 0.0 0.0 0.0 0.2 0.0 12.3 0.0 0.0 0.0 0.0 0.0 10.8 0.0 0.0 2.0 0.0 0.0 0.0 0.0 2.6 0.0 0.0 39.0 0.0 0.0 0.0 0.4 0.3 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.1 0.4 0.0 0.0 0.1 1.6 1.5 2.8 4.2 1.2 0.7 0.3 1.6 2.3 0.0 PRSS33 EOS ENSG00000103355 "Serine protease 33" Q8NF86 16 2783953-2787948 "Enzymes, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 6 "blood: 132.7" "Group enriched" "Detected in some" 9 "HMC-1: 5.1;SK-MEL-30: 10.4;U-2 OS: 3.8" "Cancer enhanced" "Detected in many" "ovarian cancer: 8.0" "Not detected" "Not detected" "Cell type enriched" "Detected in some" 78 "eosinophil: 132.7" "Lineage enriched" "Detected in single" 422 "granulocytes: 132.7" "Not detected" "Not detected" "Low region specificity" "Detected in many" "Secreted to blood" "unprognostic (4.78e-1)" "unprognostic (1.22e-1)" "unprognostic (8.99e-2)" "unprognostic (3.38e-2)" "unprognostic (3.10e-1)" "unprognostic (2.86e-2)" "unprognostic (1.16e-1)" "unprognostic (4.13e-2)" "unprognostic (1.16e-1)" "unprognostic (1.42e-2)" "unprognostic (2.28e-1)" "unprognostic (1.91e-1)" "unprognostic (2.70e-2)" 0.0 0.0 0.3 1.1 0.3 0.1 0.1 0.2 0.4 0.2 0.2 0.2 0.0 0.8 0.1 0.0 0.1 10.2 3.6 0.0 0.1 0.1 0.3 0.0 0.2 1.1 0.1 0.0 0.4 0.0 0.0 1.0 0.0 0.0 0.0 0.2 22.5 1.9 0.0 0.0 0.0 1.8 0.8 0.0 0.7 1.1 0.9 0.2 0.2 0.2 1.0 0.2 1.0 0.0 0.0 0.0 132.7 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.3 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.1 0.1 0.0 0.0 10.4 0.0 0.0 0.0 0.0 3.8 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 1.6 0.0 132.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.3 0.0 0.0 0.0 0.0 0.3 0.3 0.2 0.4 0.1 0.1 0.1 0.0 0.0 0.2 PRSS35 "C6orf158, dJ223E3.1, MGC46520" ENSG00000146250 "Serine protease 35" Q8N3Z0 6 83512538-83525704 "Enzymes, Predicted secreted proteins" "Serine protease homolog" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "blood: 17.1;ovary: 16.3" "Group enriched" "Detected in some" 4 "CACO-2: 42.1;RPTEC TERT1: 12.4" "Cancer enhanced" "Detected in some" "testis cancer: 4.7" "Low region specificity" "Detected in many" "Cell type enriched" "Detected in some" 9 "MAIT T-cell: 17.1" "Lineage enriched" "Detected in single" 172 "T-cells: 17.1" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 4 "amygdala: 4.2;cerebellum: 7.0;cerebral cortex: 7.5;hippocampal formation: 6.8;olfactory region: 5.7" "HPA038787, HPA038788" Uncertain "Secreted in female reproductive system" "HPA038787: AB_10675951, HPA038788: AB_2676208" "unprognostic (6.17e-2)" "unprognostic (8.75e-2)" "unprognostic (1.19e-2)" "unprognostic (2.63e-2)" "unprognostic (1.16e-1)" "unprognostic (4.03e-2)" "unprognostic (3.70e-4)" "unprognostic (6.08e-2)" "unprognostic (1.18e-3)" "unprognostic (2.33e-2)" "unprognostic (7.01e-2)" "unprognostic (9.07e-2)" "unprognostic (3.88e-6)" "unprognostic (7.15e-3)" "unprognostic (5.81e-2)" "unprognostic (2.82e-2)" "unprognostic (3.54e-4)" 2.0 3.8 7.7 1.3 11.3 0.0 0.6 0.2 9.3 4.8 0.4 2.5 0.3 0.5 2.2 2.1 0.6 2.2 6.2 5.6 4.8 1.1 4.9 0.7 2.0 3.0 1.1 5.4 16.3 0.6 0.9 1.5 5.2 2.7 2.7 0.6 11.1 0.4 0.7 0.4 0.5 0.4 2.2 1.4 1.1 0.6 4.6 1.3 0.0 0.7 0.4 0.2 2.0 0.9 0.0 0.0 0.0 0.0 0.0 17.1 0.1 0.0 0.2 0.9 0.0 0.0 0.0 0.0 0.1 5.1 0.5 1.0 42.1 0.0 0.0 0.0 0.2 0.0 6.3 0.0 0.3 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.0 1.6 0.0 0.6 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.8 4.1 0.0 0.0 0.0 12.4 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.4 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 1.0 0.0 17.1 0.0 0.3 1.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 7.7 11.3 0.2 7.1 4.8 1.1 1.1 5.4 2.7 1.3 PRSS36 FLJ90661 ENSG00000178226 "Serine protease 36" Q5K4E3 16 31138925-31150094 "Enzymes, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell line enhanced" "Detected in some" "HEL: 2.2;HeLa: 6.3;HMC-1: 2.8" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in some" "Cell type enhanced" "Detected in some" "eosinophil: 4.3" "Low lineage specificity" "Detected in many" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" HPA036079 Uncertain "Secreted - unknown location" "HPA036079: AB_10602290" "unprognostic (3.74e-2)" "prognostic favourable (2.97e-7)" "unprognostic (1.43e-1)" "unprognostic (1.20e-2)" "unprognostic (4.26e-3)" "unprognostic (1.31e-5)" "unprognostic (4.18e-2)" "unprognostic (5.05e-2)" "unprognostic (2.65e-2)" "unprognostic (8.03e-2)" "unprognostic (2.08e-1)" "unprognostic (1.23e-1)" "unprognostic (1.32e-3)" "unprognostic (2.39e-1)" "unprognostic (9.86e-2)" "unprognostic (1.23e-1)" "unprognostic (3.13e-1)" 3.0 2.0 0.4 1.0 1.2 1.1 6.2 0.4 1.8 1.6 1.8 0.4 0.4 3.2 0.4 1.8 1.2 0.5 0.4 2.1 0.4 0.5 0.5 0.7 2.3 0.4 0.4 0.4 1.7 0.4 0.4 6.5 2.5 0.4 1.0 0.9 0.4 3.5 0.4 1.3 3.4 2.1 1.2 0.4 0.4 1.0 0.7 0.4 0.4 0.6 0.4 1.0 2.0 0.4 0.0 2.1 4.3 0.8 0.2 0.4 0.1 0.2 0.2 0.1 0.1 0.1 0.1 0.2 0.3 0.3 0.2 0.1 0.4 1.4 0.0 0.8 0.3 1.3 0.1 0.2 0.0 0.2 0.6 2.2 6.3 1.1 0.1 0.3 2.8 0.2 0.1 0.2 0.2 0.2 0.1 0.0 0.2 0.5 0.0 0.3 0.4 0.1 0.5 0.1 0.0 0.0 0.2 0.3 0.0 0.6 0.7 0.0 0.1 1.2 0.2 0.3 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.8 4.3 0.2 0.1 0.1 0.0 0.0 0.0 2.1 0.0 0.1 0.4 2.6 0.2 0.0 0.6 0.1 0.1 0.4 1.2 0.4 1.8 0.4 0.5 0.4 0.4 0.4 0.4 PRSS37 ENSG00000165076 "Serine protease 37" A4D1T9 7 141836286-141841487 "Disease related genes, Enzymes, Potential drug targets, Predicted secreted proteins" Fertilization "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 127 "testis: 39.1" "Cell line enhanced" "Detected in some" "HL-60: 2.3;U-937: 1.4" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in some" HPA020541 Enhanced "Secreted in male reproductive system" "HPA020541: AB_1853004" "unprognostic (4.70e-2)" "unprognostic (5.56e-2)" "unprognostic (2.69e-1)" "unprognostic (2.41e-1)" "unprognostic (3.21e-2)" "unprognostic (1.30e-1)" "unprognostic (2.74e-2)" "unprognostic (1.23e-2)" "unprognostic (8.30e-7)" "unprognostic (1.42e-1)" "unprognostic (2.06e-1)" "unprognostic (2.72e-2)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 39.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 2.3 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.3 0.0 0.2 0.0 0.0 0.3 0.0 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 PRSS38 MPN2 ENSG00000185888 "Serine protease 38" A1L453 1 227815693-227846470 "Enzymes, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 19 "blood: 2.2;testis: 8.4" "Cell line enriched" "Detected in single" 20 "U-266/84: 5.1" "Not detected" "Not detected" "Group enriched" "Detected in some" 18 "gdT-cell: 1.4;NK-cell: 2.2" "Group enriched" "Detected in many" 18 "NK-cells: 2.2;T-cells: 1.4" "Not detected" "Not detected" "HPA028003, HPA055809" Enhanced "Secreted in male reproductive system" "HPA028003: AB_1853572, HPA055809: AB_2682931" "unprognostic (9.54e-3)" "unprognostic (3.61e-3)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 8.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.2 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 5.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.2 0.0 0.0 0.0 0.0 PRSS41 TESSP1 ENSG00000215148 "Serine protease 41" Q7RTY9 16 2798485-2805302 "Enzymes, Predicted intracellular proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 4 "blood: 11.6;testis: 4.0" "Cell line enriched" "Detected in single" 11 "BEWO: 6.3" "Cancer enhanced" "Detected in some" "testis cancer: 1.8" "Cell type enriched" "Detected in single" 116 "eosinophil: 11.6" "Lineage enriched" "Detected in single" 116 "granulocytes: 11.6" "unprognostic (1.58e-1)" "unprognostic (3.65e-1)" "unprognostic (3.04e-3)" "unprognostic (1.03e-1)" "unprognostic (1.71e-2)" "unprognostic (1.69e-1)" "unprognostic (1.98e-1)" "unprognostic (1.24e-2)" 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.7 0.0 0.0 0.0 0.1 0.0 0.0 1.2 4.0 0.0 0.0 0.0 0.0 0.0 11.6 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 6.3 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 11.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 PRSS42 TESSP2 ENSG00000178055 "Serine protease 42" Q7Z5A4 3 46829542-46834095 "Enzymes, Predicted secreted proteins" "Differentiation, Spermatogenesis" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at transcript level" "Group enriched" "Detected in some" 5 "heart muscle: 12.9;skeletal muscle: 19.2" "Cell line enhanced" "Detected in some" "CAPAN-2: 2.3;Daudi: 3.9;Karpas-707: 2.4;NTERA-2: 3.6" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA046925 Uncertain "Secreted - unknown location" "HPA046925: AB_10961401" "unprognostic (6.53e-2)" "unprognostic (2.72e-2)" "unprognostic (3.57e-3)" "unprognostic (9.14e-2)" "unprognostic (3.26e-1)" "unprognostic (2.37e-2)" "unprognostic (1.85e-1)" "unprognostic (6.54e-2)" "unprognostic (4.26e-2)" "unprognostic (1.14e-1)" "unprognostic (1.12e-1)" "unprognostic (1.45e-1)" "unprognostic (1.09e-2)" "unprognostic (1.38e-1)" "unprognostic (1.62e-1)" "unprognostic (7.98e-2)" 0.2 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.6 0.2 0.0 0.2 3.4 0.0 0.2 0.0 12.9 0.0 0.0 1.3 0.5 0.2 0.0 0.0 0.2 0.2 1.6 0.0 0.1 0.4 0.0 0.3 0.2 19.2 0.0 0.0 0.0 0.0 0.4 0.0 0.7 0.8 0.0 0.0 0.6 0.4 0.0 0.0 0.1 0.0 0.6 0.0 0.0 0.0 0.1 0.0 0.8 0.2 1.6 0.0 0.0 0.0 0.7 0.2 2.3 3.9 0.4 0.0 0.0 0.0 0.2 1.3 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.1 2.4 0.0 0.0 0.0 0.4 3.6 0.0 1.2 0.0 0.0 0.1 0.0 0.6 0.5 0.5 0.0 0.3 0.0 0.5 0.0 1.0 0.7 0.0 0.0 0.0 0.3 0.9 0.1 0.0 0.3 0.0 0.1 0.0 0.3 0.0 0.0 0.0 0.6 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 PRSS45 TESSP5 ENSG00000188086 "Serine protease 45" Q7RTY3 3 46742092-46744755 "Enzymes, Predicted intracellular proteins" "Hydrolase, Protease, Serine protease" "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Tissue enhanced" "Detected in some" "epididymis: 7.6;skeletal muscle: 6.7" "Cell line enhanced" "Detected in some" "Daudi: 1.2;HBF TERT88: 1.0;HHSteC: 2.6" "Low cancer specificity" "Detected in single" "Cell type enriched" "Detected in single" 19 "naive B-cell: 1.9" "Lineage enriched" "Detected in single" 19 "B-cells: 1.9" HPA060284 Uncertain "HPA060284: " "unprognostic (4.55e-3)" "unprognostic (3.49e-2)" "unprognostic (1.07e-2)" "unprognostic (2.50e-1)" "unprognostic (6.07e-2)" "unprognostic (1.28e-2)" "unprognostic (1.06e-1)" "unprognostic (6.20e-2)" "unprognostic (1.54e-1)" "unprognostic (1.30e-1)" "unprognostic (3.83e-4)" "unprognostic (2.33e-2)" "unprognostic (6.60e-3)" "unprognostic (1.27e-2)" "unprognostic (1.57e-2)" "unprognostic (2.15e-1)" "unprognostic (5.97e-3)" 0.0 0.0 0.0 0.0 0.0 0.0 1.5 0.0 0.0 1.5 0.2 0.1 0.2 7.6 0.1 0.8 0.0 0.2 0.0 0.0 0.9 0.7 0.2 0.1 0.0 0.3 1.3 2.0 0.5 0.1 0.5 0.0 0.5 0.3 6.7 0.3 0.0 0.0 0.0 0.0 0.2 1.6 3.2 0.0 0.4 0.4 1.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.7 0.3 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 2.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.7 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 PRSS48 ESSPL ENSG00000189099 "Serine protease 48" Q7RTY5 4 151277171-151291453 "Enzymes, Predicted membrane proteins, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Group enriched" "Detected in some" 5 "brain: 1.0;skin 1: 1.9;testis: 4.1" "Cell line enhanced" "Detected in some" "HHSteC: 1.4;LHCN-M2: 1.3;PC-3: 1.5;RT4: 1.0" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in all" HPA053801 Uncertain "Secreted in male reproductive system" "HPA053801: " "unprognostic (9.68e-2)" "unprognostic (1.35e-2)" "unprognostic (2.15e-1)" "unprognostic (2.18e-2)" "unprognostic (3.76e-2)" "unprognostic (4.10e-2)" 0.0 0.0 0.5 0.0 1.0 0.0 0.0 0.0 0.9 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.7 0.1 0.0 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.3 0.0 1.9 0.0 0.0 0.5 0.0 0.0 4.1 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 1.4 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.3 0.0 0.0 0.0 0.6 1.5 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 PRSS50 "CT20, TSP50" ENSG00000206549 "Serine protease 50" Q9UI38 3 46712115-46812574 "Enzymes, Predicted intracellular proteins" "Hydrolase, Protease, Threonine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "testis: 22.3" "Cell line enhanced" "Detected in some" "BEWO: 1.0;NTERA-2: 2.6" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Not detected" "Not detected" HPA040768 Supported "HPA040768: " "unprognostic (1.19e-2)" "unprognostic (1.63e-1)" "unprognostic (1.63e-2)" "unprognostic (7.59e-3)" "unprognostic (4.32e-1)" "unprognostic (7.45e-2)" "unprognostic (9.24e-2)" "unprognostic (1.37e-1)" "unprognostic (6.77e-2)" "unprognostic (2.23e-1)" "unprognostic (8.91e-4)" "unprognostic (1.08e-1)" "unprognostic (1.46e-3)" "unprognostic (2.68e-2)" "unprognostic (1.79e-2)" "unprognostic (9.36e-2)" "unprognostic (3.66e-3)" 0.1 0.7 0.0 0.0 0.0 0.0 0.6 0.4 0.3 1.3 0.2 0.1 0.7 6.2 0.1 0.5 0.0 0.9 0.0 0.6 1.8 0.7 0.2 0.0 0.0 0.7 1.7 4.7 8.2 0.0 1.6 0.0 1.7 1.7 7.7 0.0 0.0 0.2 0.0 0.0 0.2 22.3 7.9 0.0 0.2 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.1 0.0 0.3 0.6 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.1 0.0 0.3 0.0 0.0 0.2 0.0 0.2 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.1 2.6 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.5 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 PRSS50 "CT20, TSP50" ENSG00000283706 "Serine protease 50" Q9UI38 3 46712115-46717907 "Enzymes, Predicted intracellular proteins" "Hydrolase, Protease, Threonine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 11 "testis: 33.4" "Cell line enhanced" "Detected in some" "EFO-21: 2.0;HMC-1: 5.3;NTERA-2: 2.0" "Not detected" "Not detected" "Not detected" "Not detected" HPA040768 Supported "Intracellular and membrane" "HPA040768: " 0.1 0.8 0.1 0.1 0.1 0.0 0.2 0.1 0.1 0.1 0.1 0.1 0.1 0.0 0.1 2.9 0.1 0.2 0.1 0.1 0.1 0.2 0.1 0.1 0.1 0.3 0.1 0.3 0.9 1.7 1.1 0.1 0.1 0.2 0.0 0.1 1.6 1.8 0.1 0.0 0.1 0.1 0.1 0.1 0.0 33.4 0.1 0.4 1.6 0.1 0.2 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.7 0.1 0.1 0.0 0.0 0.0 0.2 0.0 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 2.0 0.2 0.0 0.0 0.0 0.3 0.8 0.4 0.0 0.0 0.0 0.4 0.0 5.3 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 2.0 0.0 0.2 0.1 0.0 0.0 0.1 0.3 0.5 0.0 0.2 0.2 0.0 0.0 0.0 0.3 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.1 PRSS51 ENSG00000253649 "Serine protease 51" A0A1B0GVH4 8 10482878-10547585 "Enzymes, Predicted intracellular proteins, Predicted secreted proteins" "Evidence at transcript level" "Evidence at transcript level" "No human protein/transcript evidence" "No human protein/transcript evidence" "Group enriched" "Detected in some" 5 "brain: 1.4;breast: 3.4;liver: 1.5;testis: 2.3" "Cell line enhanced" "Detected in some" "AN3-CA: 1.7;CAPAN-2: 1.6;T-47d: 1.9;U-2 OS: 5.1" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Not detected" "Not detected" "Secreted - unknown location" "unprognostic (2.52e-1)" "unprognostic (3.00e-1)" "unprognostic (3.10e-1)" "unprognostic (1.90e-1)" "unprognostic (1.06e-1)" "unprognostic (2.22e-2)" "unprognostic (2.72e-1)" "unprognostic (7.48e-2)" "unprognostic (1.64e-1)" "unprognostic (7.94e-2)" "unprognostic (1.02e-1)" "unprognostic (6.33e-3)" "unprognostic (2.71e-3)" "unprognostic (7.47e-2)" "unprognostic (3.42e-1)" "unprognostic (1.08e-1)" "unprognostic (1.06e-1)" 0.0 0.0 0.0 0.4 3.4 1.4 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.0 2.3 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.1 0.2 0.0 0.0 0.3 1.7 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 1.6 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.2 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.3 0.1 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 1.9 0.6 0.0 0.0 5.1 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.3 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.2 PRSS53 POL3S ENSG00000151006 "Serine protease 53" Q2L4Q9 16 31083425-31089628 "Enzymes, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Tissue enhanced" "Detected in some" "liver: 10.9" "Cell line enhanced" "Detected in some" "SCLC-21H: 9.8" "Low cancer specificity" "Detected in some" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "HPA034955, HPA034956" Uncertain "Secreted - unknown location" "HPA034955: , HPA034956: AB_10696365" "unprognostic (3.13e-1)" "unprognostic (4.15e-1)" "unprognostic (3.88e-3)" "unprognostic (1.62e-1)" "unprognostic (1.20e-1)" "unprognostic (1.63e-2)" "unprognostic (1.84e-1)" "unprognostic (2.63e-2)" "unprognostic (1.04e-2)" "unprognostic (2.87e-2)" "unprognostic (2.72e-2)" "unprognostic (1.63e-4)" "unprognostic (2.53e-12)" "unprognostic (1.02e-1)" "unprognostic (2.01e-1)" "unprognostic (1.37e-1)" "unprognostic (1.16e-1)" 0.3 0.0 0.0 0.5 0.3 0.0 0.1 2.9 0.4 0.2 0.3 1.4 1.0 0.0 0.1 0.3 0.6 0.2 0.1 0.3 0.6 10.9 0.5 0.9 0.1 0.3 2.2 0.0 0.8 0.2 1.2 0.0 0.0 0.8 0.0 3.9 0.5 0.4 0.2 1.0 1.3 0.0 0.3 0.0 0.5 0.3 0.3 0.0 0.0 0.0 0.0 0.4 0.8 0.3 0.0 0.3 0.0 0.0 0.0 1.0 0.5 1.1 1.0 0.0 0.2 0.0 0.3 0.7 0.0 1.3 0.0 0.0 0.0 0.0 1.4 0.0 0.0 0.0 0.0 0.3 0.0 0.8 0.5 0.0 0.0 0.0 0.1 0.3 0.1 1.3 0.3 1.6 0.8 1.9 1.6 0.0 0.0 0.0 0.0 9.8 0.8 0.9 0.0 1.0 0.7 0.1 0.7 1.0 0.7 2.5 0.2 1.4 0.1 0.3 2.4 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.3 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.8 PRSS54 "CT67, FLJ25339, KLKBL4" ENSG00000103023 "Serine protease 54" Q6PEW0 16 58279997-58295047 "Enzymes, Predicted intracellular proteins, Predicted secreted proteins" "Serine protease homolog" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 95 "testis: 35.1" "Cell line enhanced" "Detected in single" "BEWO: 1.3" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in many" HPA041549 Enhanced "Secreted in male reproductive system" "HPA041549: AB_10795640" "unprognostic (1.13e-1)" "unprognostic (3.24e-2)" "unprognostic (3.09e-2)" "unprognostic (3.08e-1)" "unprognostic (4.88e-2)" "unprognostic (1.23e-1)" 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.3 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 35.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.2 0.0 0.0 0.8 0.0 0.0 1.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.1 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 PRSS55 "CT153, T-SP1, UNQ9391" ENSG00000184647 "Serine protease 55" Q6UWB4 8 10525546-10554166 "Enzymes, Predicted intracellular proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 67 "testis: 25.5" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in all" "Intracellular and membrane" "unprognostic (3.64e-1)" "unprognostic (8.44e-3)" "unprognostic (6.10e-2)" "unprognostic (7.40e-2)" "unprognostic (6.23e-5)" "unprognostic (6.62e-2)" 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 25.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.3 0.0 0.1 0.0 0.0 0.0 0.0 0.0 PRSS56 ENSG00000237412 "Serine protease 56" P0CW18 2 232520463-232525716 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" "Hydrolase, Protease, Serine protease" "Disease mutation, Microphthalmia" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "brain: 4.4;retina: 8.6;skeletal muscle: 16.2" "Cell line enriched" "Detected in single" 5 "Daudi: 4.6" "Cancer enhanced" "Detected in many" "urothelial cancer: 4.7" "Region enhanced" "Detected in many" "hypothalamus: 4.4" "Not detected" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 10 "basal ganglia: 1.6;olfactory region: 5.2" "Region enhanced" "Detected in many" "olfactory region: 32.6" "unprognostic (3.26e-1)" "unprognostic (1.98e-2)" "unprognostic (1.31e-1)" "unprognostic (3.73e-3)" "unprognostic (2.28e-1)" "unprognostic (7.15e-2)" "unprognostic (4.64e-2)" "unprognostic (1.20e-1)" 0.1 0.1 0.3 0.1 1.8 0.1 0.1 0.1 1.0 0.1 0.1 0.1 0.1 0.1 0.1 1.1 0.1 0.1 0.1 0.1 0.2 4.4 0.1 0.1 0.1 0.1 2.2 0.1 0.6 0.1 0.1 0.1 0.1 0.1 0.2 0.1 8.6 0.1 0.1 16.2 0.1 0.1 0.1 0.8 0.2 0.1 2.6 0.1 1.1 0.1 0.1 0.1 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 4.6 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.8 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 1.8 0.1 1.0 0.2 4.4 2.2 0.1 0.1 0.1 PRSS57 "PRSSL1, UNQ782" ENSG00000185198 "Serine protease 57" Q6UWY2 19 685546-695498 "Enzymes, Predicted secreted proteins" "Heparin-binding, Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 7 "bone marrow: 61.8" "Group enriched" "Detected in some" 13 "NB-4: 85.1;THP-1: 42.6" "Cancer enriched" "Detected in single" 10 "pancreatic cancer: 2.2" "Not detected" "Not detected" "Cell type enhanced" "Detected in many" "basophil: 8.7" "Low lineage specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected" "Not detected" "Secreted to blood" "unprognostic (2.89e-1)" "unprognostic (1.43e-1)" "unprognostic (2.10e-1)" "unprognostic (3.99e-4)" "unprognostic (3.07e-1)" "unprognostic (1.33e-2)" "unprognostic (3.50e-2)" "unprognostic (4.04e-2)" "unprognostic (7.70e-2)" "unprognostic (3.80e-1)" "unprognostic (1.11e-1)" "unprognostic (3.46e-2)" "unprognostic (8.16e-2)" "unprognostic (2.56e-2)" 0.3 0.2 0.0 0.0 0.0 61.8 0.2 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.1 0.0 0.4 0.6 0.0 3.9 0.0 0.1 0.2 0.8 4.0 0.1 0.1 0.0 0.9 0.0 0.0 0.1 0.4 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 5.1 0.0 0.2 0.0 9.3 0.3 0.0 0.9 0.0 0.2 0.0 2.2 8.7 1.6 3.1 4.5 4.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.0 0.0 0.0 0.0 1.7 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 85.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 42.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 8.7 1.6 0.0 0.6 0.3 0.0 0.0 0.0 4.5 2.2 0.0 0.0 0.8 1.0 3.1 0.0 0.1 0.0 4.1 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 PRSS58 TRYX3 ENSG00000258223 "Serine protease 58" Q8IYP2 7 142252143-142258058 "Enzymes, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 85 "testis: 27.2" "Cell line enriched" "Detected in single" 22 "RH-30: 2.1" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in single" "Secreted in male reproductive system" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 27.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 PRSS8 ENSG00000052344 "Serine protease 8" Q16651 16 31131433-31135762 "Enzymes, Predicted membrane proteins, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 123.2;salivary gland: 143.7" "Cell line enhanced" "Detected in some" "BEWO: 57.3;CACO-2: 37.6;CAPAN-2: 25.8;hTCEpi: 37.0;SK-BR-3: 43.5" "Low cancer specificity" "Detected in many" "Region enriched" "Detected in single" 4 "pons and medulla: 3.4" "Cell type enhanced" "Detected in single" "neutrophil: 1.0" "Low lineage specificity" "Detected in single" "Not detected" "Not detected" "Not detected" "Not detected" HPA030436 Uncertain "Secreted - unknown location" 3500000 "HPA030436: AB_10602291" "unprognostic (1.88e-1)" "unprognostic (2.97e-1)" "unprognostic (9.34e-2)" "unprognostic (4.08e-1)" "unprognostic (6.83e-2)" "unprognostic (5.07e-3)" "unprognostic (5.78e-2)" "unprognostic (2.05e-1)" "unprognostic (2.26e-1)" "unprognostic (4.51e-2)" "unprognostic (8.74e-3)" "unprognostic (1.58e-1)" "prognostic favourable (2.05e-10)" "unprognostic (1.89e-2)" "unprognostic (1.20e-1)" "unprognostic (1.31e-1)" "unprognostic (3.63e-3)" 0.3 0.2 0.3 11.5 0.3 0.0 7.6 0.7 0.4 8.0 72.6 0.6 12.8 31.6 3.4 46.7 37.2 2.8 45.3 0.3 0.4 0.3 48.0 20.3 30.0 0.3 0.3 0.3 1.3 46.3 2.7 2.6 93.1 3.4 11.4 14.7 1.1 143.7 7.4 0.3 29.7 123.2 0.5 0.3 0.3 37.0 1.8 0.3 11.3 33.4 18.4 26.7 2.6 13.4 0.2 0.0 1.0 0.3 0.0 0.2 0.0 14.2 0.0 0.0 0.0 0.0 0.0 57.3 0.0 0.0 0.0 0.0 37.6 25.8 0.0 0.3 0.0 17.0 0.0 16.0 0.0 0.0 0.1 0.0 0.0 1.4 0.0 0.0 0.0 0.0 37.0 0.0 0.5 0.0 0.4 0.0 0.0 15.3 0.1 0.3 4.7 0.0 0.1 0.0 0.2 1.7 3.0 0.2 0.1 0.0 43.5 0.0 9.9 0.2 0.0 0.0 0.4 0.1 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.2 0.2 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.3 0.3 0.7 0.4 0.4 0.3 0.3 0.3 3.4 0.3 PRTN3 "ACPA, AGP7, C-ANCA, MBT, P29, PR-3" ENSG00000196415 "Proteinase 3" P24158 19 840960-848175 "Candidate cardiovascular disease genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins" "Collagen degradation" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 5 "bone marrow: 167.3" "Cell line enriched" "Detected in some" 5 "THP-1: 148.0" "Cancer enhanced" "Detected in single" "stomach cancer: 1.0" "Low region specificity" "Detected in some" "Cell type enriched" "Detected in single" 8 "neutrophil: 1.9" "Lineage enriched" "Detected in single" 8 "granulocytes: 1.9" "Low region specificity" "Detected in some" "Not detected" "Not detected" "HPA005938, CAB017558" Enhanced "Secreted to blood" 120000 "CAB017558: AB_2172317, HPA005938: AB_1855764" "unprognostic (2.81e-2)" "unprognostic (2.10e-1)" "unprognostic (3.83e-3)" "unprognostic (4.20e-1)" "unprognostic (3.31e-2)" "unprognostic (3.34e-1)" "unprognostic (9.98e-3)" "unprognostic (3.67e-2)" "unprognostic (8.62e-6)" "unprognostic (5.31e-2)" "unprognostic (2.00e-1)" "unprognostic (5.14e-2)" 0.3 0.2 0.9 0.2 1.0 167.3 0.2 0.0 2.3 0.2 0.2 0.7 0.0 0.2 0.2 0.2 0.2 0.2 0.2 31.0 0.3 0.6 0.2 1.7 8.1 3.5 0.1 0.1 0.4 0.2 0.2 0.8 4.2 0.8 0.2 0.2 0.3 0.3 0.2 0.5 0.3 0.2 0.2 0.0 25.5 0.2 0.2 0.1 35.0 0.9 0.0 0.2 0.2 0.0 0.0 0.0 1.9 0.1 0.0 0.2 6.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 27.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 148.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.1 0.0 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.9 0.0 0.0 0.0 0.0 6.8 0.9 1.0 0.0 2.3 0.3 0.6 0.1 0.1 0.8 0.1 PSEN1 "AD3, FAD, PS1, S182" ENSG00000080815 "Presenilin 1" P49768 14 73136418-73223691 "Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Apoptosis, Cell adhesion, Notch signaling pathway" "Hydrolase, Protease" "Alzheimer disease, Amyloidosis, Cancer-related genes, Cardiomyopathy, Disease mutation, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB006844, HPA030760, HPA067496" Approved Approved "Nucleoplasm,Golgi apparatus,Cell Junctions" "Golgi apparatus" "Nucleoplasm, Cell Junctions" "CAB006844: , HPA030760: AB_10696211, HPA067496: " "unprognostic (1.67e-1)" "unprognostic (4.79e-2)" "unprognostic (7.39e-2)" "unprognostic (8.68e-3)" "unprognostic (3.84e-1)" "unprognostic (5.48e-3)" "prognostic unfavourable (1.99e-5)" "unprognostic (1.65e-1)" "unprognostic (8.99e-2)" "unprognostic (8.45e-2)" "unprognostic (1.76e-3)" "unprognostic (2.74e-1)" "prognostic favourable (1.52e-8)" "unprognostic (2.29e-1)" "unprognostic (2.32e-1)" "unprognostic (7.12e-3)" "unprognostic (1.85e-1)" 16.3 15.3 21.0 13.4 34.9 19.2 15.7 15.5 24.7 16.5 26.2 66.1 9.5 26.6 14.2 15.4 19.0 12.6 17.1 9.9 28.6 18.2 19.7 16.9 16.9 10.8 42.1 20.7 13.5 15.0 21.8 9.2 22.7 31.8 13.6 25.6 15.0 16.8 13.4 13.0 24.7 27.9 14.6 61.9 14.6 16.3 16.8 39.7 15.4 19.7 8.7 15.9 17.2 13.5 9.0 24.4 38.1 34.0 11.7 10.5 17.1 14.2 21.9 20.5 8.1 28.7 20.5 18.7 21.0 24.1 21.5 27.2 27.2 35.7 9.3 13.9 19.9 38.0 17.2 15.9 23.6 21.2 10.7 10.6 14.9 13.2 26.5 10.7 20.8 21.0 28.9 17.8 22.0 17.2 11.8 19.0 20.1 28.3 8.1 13.9 8.9 16.3 10.3 17.4 11.8 30.0 30.3 11.4 15.2 22.9 21.5 18.7 26.6 23.9 18.2 21.9 18.1 17.9 9.9 12.4 18.2 9.4 18.4 13.0 13.3 29.2 27.1 27.1 7.2 30.8 7.0 7.2 7.0 5.9 24.4 9.0 6.6 6.4 38.1 11.7 34.0 12.8 10.5 17.1 21.0 34.9 15.5 24.7 28.6 18.2 42.1 20.7 31.8 39.7 PSEN2 "AD3L, AD4, PS2, STM2" ENSG00000143801 "Presenilin 2" P49810 1 226870184-226896105 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Notch signaling pathway" "Hydrolase, Protease" "Alzheimer disease, Amyloidosis, Cardiomyopathy, Disease mutation, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB013634, HPA038005" Supported Nucleoplasm Nucleoplasm "CAB013634: , HPA038005: " "unprognostic (3.40e-2)" "unprognostic (4.73e-3)" "unprognostic (2.94e-1)" "unprognostic (3.86e-2)" "unprognostic (6.54e-2)" "unprognostic (1.64e-3)" "unprognostic (4.72e-2)" "unprognostic (1.31e-1)" "unprognostic (9.98e-2)" "unprognostic (2.73e-2)" "unprognostic (8.25e-3)" "unprognostic (8.53e-3)" "unprognostic (8.45e-2)" "unprognostic (1.17e-1)" "unprognostic (8.36e-2)" "unprognostic (1.68e-1)" "unprognostic (1.06e-1)" 8.9 13.2 9.5 5.9 7.9 1.2 8.1 16.6 10.7 9.2 9.2 5.9 7.3 9.4 16.4 9.0 9.4 8.7 12.0 9.7 6.5 10.8 7.8 7.7 9.0 11.6 8.1 9.3 13.1 31.6 14.0 15.2 7.6 14.8 12.8 6.9 15.9 9.6 13.4 22.1 6.8 12.2 17.0 4.9 10.6 7.1 21.8 5.3 1.4 6.0 7.2 7.0 9.0 7.2 5.1 7.7 19.4 18.7 12.3 3.4 3.1 8.9 13.4 4.0 12.4 5.5 1.8 6.7 7.6 14.9 9.5 7.3 10.5 11.5 0.1 10.3 9.7 4.6 7.1 7.2 3.9 9.6 12.9 6.1 9.5 6.8 9.2 4.7 10.0 5.3 8.1 11.4 6.2 4.4 10.4 4.1 5.5 7.5 0.1 5.4 12.3 11.1 0.1 14.7 14.4 8.4 7.6 7.0 11.7 6.1 16.9 30.2 14.5 6.0 4.8 6.8 5.7 6.2 9.5 16.4 24.1 0.4 12.0 1.5 8.9 19.4 5.7 12.1 3.2 6.5 3.4 5.1 1.1 2.9 7.7 2.6 0.6 1.7 1.2 12.3 18.7 0.6 1.4 3.1 9.5 7.9 16.6 10.7 6.5 10.8 8.1 9.3 14.8 5.3 PSMA1 "HC2, MGC14542, MGC14575, MGC14751, MGC1667, MGC21459, MGC22853, MGC23915, NU, PROS30" ENSG00000129084 "Proteasome subunit alpha 1" P25786 11 14504874-14643635 "Enzymes, Predicted intracellular proteins" Immunity "Hydrolase, Protease, Threonine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "CAB033765, HPA037646, HPA043891" Supported Enhanced Nucleoplasm 27000000 Nucleoplasm "CAB033765: AB_2253026, HPA037646: AB_10670386, HPA043891: AB_2678718" "unprognostic (1.72e-2)" "unprognostic (4.97e-2)" "unprognostic (7.33e-2)" "unprognostic (4.74e-2)" "unprognostic (7.52e-2)" "unprognostic (6.66e-3)" "prognostic unfavourable (3.79e-5)" "unprognostic (3.28e-3)" "unprognostic (7.44e-2)" "unprognostic (3.43e-3)" "unprognostic (8.27e-3)" "unprognostic (8.77e-2)" "prognostic unfavourable (4.03e-11)" "unprognostic (1.93e-1)" "unprognostic (1.69e-1)" "unprognostic (4.66e-2)" "unprognostic (1.23e-2)" 46.6 46.3 33.7 36.0 40.2 45.7 39.0 28.3 42.7 33.4 35.5 23.1 37.4 37.3 42.1 43.1 43.7 33.0 32.2 55.4 31.7 34.1 47.8 61.0 38.8 42.3 32.0 32.4 34.0 35.6 28.2 39.4 55.2 36.9 35.6 42.4 32.9 34.9 37.1 86.6 35.3 42.7 39.0 26.7 45.8 37.3 31.6 25.9 53.0 45.5 62.8 42.2 41.5 31.7 24.2 55.4 20.9 42.3 30.5 35.7 45.2 66.1 46.8 39.2 46.9 39.1 39.4 32.7 39.1 51.5 59.7 49.1 40.5 83.6 57.9 43.4 41.3 49.9 44.7 48.5 56.6 56.2 66.4 36.1 31.1 47.8 51.4 59.8 47.2 38.2 28.9 32.4 67.8 58.4 67.6 48.8 53.0 43.9 54.4 45.0 32.7 69.8 36.9 58.1 35.9 51.9 46.9 32.4 20.4 41.7 46.8 34.9 27.9 36.6 46.1 39.1 36.8 68.4 47.8 21.4 57.2 51.8 57.8 47.7 49.9 20.9 42.3 11.0 24.3 31.1 32.3 24.2 28.3 27.2 55.4 20.6 25.7 25.0 9.4 30.5 29.4 31.3 35.7 45.2 33.7 40.2 28.3 42.7 31.7 34.1 32.0 32.4 36.9 25.9 PSMA2 "HC3, MU, PMSA2" ENSG00000106588 "Proteasome subunit alpha 2" P25787 7 42916857-42932223 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Hydrolase, Protease, Threonine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" HPA008188 Uncertain 80000000 "HPA008188: AB_1855819" "unprognostic (9.40e-3)" "unprognostic (2.08e-2)" "unprognostic (8.21e-2)" "unprognostic (2.23e-2)" "unprognostic (4.13e-2)" "unprognostic (1.90e-1)" "prognostic unfavourable (1.29e-4)" "unprognostic (2.01e-2)" "unprognostic (9.25e-2)" "prognostic favourable (6.73e-5)" "unprognostic (1.77e-1)" "unprognostic (3.42e-1)" "unprognostic (1.62e-3)" "unprognostic (1.79e-1)" "unprognostic (1.06e-1)" "unprognostic (6.38e-2)" "unprognostic (4.24e-2)" 24.7 32.2 25.3 24.6 29.5 29.7 29.4 19.6 22.0 19.2 25.6 13.4 26.0 29.8 22.6 26.2 31.1 19.4 20.5 35.8 22.3 16.6 33.3 90.9 23.2 27.4 27.2 17.6 20.8 28.8 12.0 18.8 33.7 29.2 24.5 26.0 10.1 21.7 19.6 57.2 22.4 33.1 22.0 21.4 26.6 27.8 18.6 23.5 42.2 29.9 44.6 29.9 22.8 20.2 46.2 54.1 81.7 47.4 36.7 56.7 75.0 31.9 34.3 40.3 48.6 21.5 24.2 30.1 28.2 33.1 45.7 49.0 51.0 52.6 59.4 50.5 25.0 44.7 41.5 39.2 52.7 42.9 33.0 30.2 46.5 53.8 23.0 51.3 32.8 22.2 28.6 35.2 21.0 42.9 60.9 36.5 36.5 37.4 45.7 100.9 79.7 42.6 44.7 39.2 58.3 43.9 44.1 32.8 33.3 30.7 70.6 30.9 51.4 60.1 30.6 27.1 49.4 29.0 55.6 47.6 72.1 97.2 46.1 65.2 76.5 59.0 45.7 81.7 35.2 45.2 40.4 46.2 43.4 40.5 48.5 40.7 39.0 41.3 23.3 36.7 47.4 54.1 56.7 75.0 25.3 29.5 19.6 22.0 22.3 16.6 27.2 17.6 29.2 23.5 PSMA3 HC8 ENSG00000100567 "Proteasome subunit alpha 3" P25788 14 58244831-58272012 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Host-virus interaction" "Hydrolase, Protease, Threonine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA000905 Approved 13000000 "HPA000905: AB_1079702" "unprognostic (3.60e-1)" "unprognostic (4.81e-3)" "unprognostic (1.17e-1)" "unprognostic (2.19e-2)" "unprognostic (4.91e-1)" "unprognostic (5.79e-2)" "unprognostic (1.97e-3)" "unprognostic (1.27e-1)" "unprognostic (7.92e-2)" "unprognostic (7.36e-3)" "unprognostic (1.65e-2)" "unprognostic (7.57e-2)" "unprognostic (1.83e-3)" "unprognostic (2.33e-2)" "unprognostic (6.47e-2)" "prognostic favourable (2.91e-4)" "unprognostic (2.16e-1)" 26.6 41.5 21.3 27.7 25.0 24.3 28.7 16.2 25.1 23.3 26.5 17.5 34.3 27.7 25.4 46.3 33.5 23.4 21.1 55.8 24.2 22.6 51.2 59.6 28.0 31.9 23.2 20.3 23.5 25.1 20.0 30.8 50.6 28.3 24.7 28.9 17.5 25.0 27.7 68.6 18.1 34.4 27.0 22.4 33.9 26.9 15.9 15.8 32.5 37.6 50.6 31.2 32.0 20.5 36.1 50.7 31.2 40.3 38.0 45.9 36.1 66.5 41.5 41.3 33.9 32.5 30.5 53.2 35.2 39.5 49.4 49.7 61.3 55.4 56.1 65.5 31.8 45.9 47.0 37.6 58.1 49.2 28.8 38.4 31.4 69.1 61.7 61.8 33.0 26.0 27.2 34.3 32.7 58.0 36.3 33.2 39.6 75.8 53.9 59.8 28.0 63.0 45.8 53.6 41.5 71.2 65.9 39.0 19.5 31.3 49.8 34.3 51.9 46.4 37.1 28.9 56.4 32.5 47.0 13.4 25.0 57.9 41.6 48.6 34.8 31.2 34.3 20.6 32.4 40.3 40.6 36.1 39.7 38.1 37.9 25.6 32.4 37.2 20.1 38.0 33.7 50.7 45.9 36.1 21.3 25.0 16.2 25.1 24.2 22.6 23.2 20.3 28.3 15.8 PSMA4 "HC9, HsT17706" ENSG00000041357 "Proteasome subunit alpha 4" P25789 15 78540405-78552419 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Host-virus interaction" "Hydrolase, Protease, Threonine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004973, HPA055466, HPA060613" Supported Supported Nucleoplasm,Vesicles,Cytosol 12000000 "Nucleoplasm, Cytosol" Vesicles "CAB004973: AB_425627, HPA055466: , HPA060613: " "unprognostic (1.80e-1)" "unprognostic (7.08e-3)" "unprognostic (1.31e-1)" "unprognostic (1.62e-1)" "unprognostic (4.71e-2)" "unprognostic (5.35e-2)" "unprognostic (6.26e-3)" "unprognostic (1.09e-1)" "unprognostic (3.28e-2)" "unprognostic (2.08e-3)" "unprognostic (2.75e-3)" "unprognostic (1.26e-1)" "prognostic unfavourable (6.74e-10)" "unprognostic (1.68e-1)" "unprognostic (1.56e-1)" "unprognostic (3.78e-3)" "unprognostic (6.32e-3)" 41.2 38.8 24.9 36.7 25.8 33.4 33.0 25.3 37.5 32.4 38.0 17.9 23.7 39.4 35.3 32.5 49.9 27.1 24.4 37.7 29.8 27.6 55.7 76.3 37.4 45.1 25.5 26.9 31.2 24.4 20.2 25.9 55.4 33.8 35.3 41.3 19.1 26.0 25.0 60.3 26.3 49.1 36.6 28.1 45.5 31.5 36.5 21.4 61.6 42.6 75.0 44.8 41.3 28.3 29.4 61.9 31.4 75.6 37.7 40.0 61.4 40.1 58.2 50.4 44.4 31.8 30.1 39.5 37.8 30.4 46.6 50.0 60.5 58.7 87.7 55.9 34.8 55.0 101.6 41.0 45.1 35.9 70.8 73.6 43.6 48.7 51.6 74.8 45.5 24.3 25.7 39.2 39.1 50.2 78.9 34.4 38.0 57.8 50.4 70.2 47.4 34.2 43.9 66.7 29.4 47.2 70.4 44.5 32.5 60.6 44.3 46.1 40.9 61.6 39.9 34.8 46.5 38.3 64.3 31.5 74.2 82.7 32.6 112.5 38.3 18.8 47.4 31.4 27.8 75.6 28.5 29.4 29.2 29.0 61.9 22.9 23.3 28.3 21.7 37.7 69.7 35.3 40.0 61.4 24.9 25.8 25.3 37.5 29.8 27.6 25.5 26.9 33.8 21.4 PSMA5 ZETA ENSG00000143106 "Proteasome subunit alpha 5" P28066 1 109399031-109426427 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Hydrolase, Protease, Threonine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell line enhanced" "Detected in many" "MOLT-4: 30.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA028392, HPA028398, HPA028441" Approved Supported Cytosol 22000000 Cytosol "HPA028392: AB_10600115, HPA028398: AB_10602310, HPA028441: AB_10602003" "unprognostic (3.82e-2)" "unprognostic (3.09e-3)" "prognostic favourable (1.45e-5)" "unprognostic (1.57e-1)" "unprognostic (2.71e-1)" "unprognostic (1.52e-2)" "prognostic unfavourable (2.28e-4)" "unprognostic (5.95e-2)" "unprognostic (1.71e-2)" "unprognostic (1.13e-3)" "unprognostic (4.20e-3)" "unprognostic (3.05e-1)" "unprognostic (1.07e-3)" "unprognostic (3.99e-2)" "unprognostic (2.34e-1)" "unprognostic (8.81e-3)" "unprognostic (1.05e-1)" 12.1 23.7 13.2 17.3 15.0 7.7 16.2 8.2 40.5 13.3 16.1 9.8 16.7 15.1 15.8 23.0 21.5 17.6 16.7 20.8 13.8 13.5 27.5 41.9 17.1 24.2 13.4 14.9 13.6 21.4 12.6 11.5 20.9 12.8 12.3 14.9 10.2 16.8 14.2 31.6 15.8 21.8 14.4 12.9 18.5 15.2 16.3 10.3 31.5 27.9 23.4 19.8 14.0 11.7 2.1 1.2 7.3 2.2 2.8 7.1 1.6 1.2 1.0 1.6 1.2 3.8 4.1 1.4 0.9 9.1 6.0 3.5 1.2 1.1 5.2 1.2 4.0 1.6 2.3 3.1 3.7 1.1 1.5 2.2 0.9 1.5 2.9 2.9 1.2 1.9 3.0 1.8 3.0 2.2 1.8 1.4 2.5 1.5 30.5 1.2 1.4 1.5 0.8 3.1 0.8 4.8 1.6 1.4 1.1 1.6 5.4 1.9 1.2 2.6 1.4 1.0 0.7 2.1 1.2 0.8 1.8 6.6 6.6 6.6 1.0 7.3 1.0 0.7 4.0 2.2 4.8 1.8 5.8 4.9 1.2 2.1 7.1 6.5 0.3 2.8 2.0 0.8 5.3 1.6 13.2 15.0 8.2 17.5 13.8 13.5 13.4 14.9 12.8 10.3 PSMA6 "IOTA, MGC22756, MGC2333, MGC23846, p27K, PROS27" ENSG00000100902 "Proteasome subunit alpha 6" P60900 14 35278633-35317493 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Hydrolase, Protease, Threonine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA003049 Approved Supported Nucleoplasm 19000000 Nucleoplasm "HPA003049: AB_1079703" "unprognostic (9.68e-3)" "unprognostic (5.91e-2)" "unprognostic (1.90e-2)" "unprognostic (8.07e-2)" "unprognostic (3.42e-2)" "unprognostic (4.11e-3)" "unprognostic (7.48e-2)" "unprognostic (1.25e-1)" "unprognostic (1.16e-1)" "prognostic favourable (3.27e-4)" "unprognostic (1.29e-3)" "unprognostic (2.63e-1)" "unprognostic (1.52e-2)" "unprognostic (2.05e-1)" "unprognostic (5.45e-2)" "unprognostic (3.49e-1)" "unprognostic (5.08e-2)" 33.8 42.7 26.7 31.4 38.8 37.1 38.7 24.2 35.0 28.0 35.8 19.4 24.5 32.2 31.0 30.2 37.9 24.7 20.3 54.2 30.5 27.6 47.3 49.0 37.3 36.4 30.1 36.8 31.1 36.7 14.2 35.8 61.2 31.8 22.5 38.6 18.1 27.3 25.5 94.6 31.8 39.5 27.3 25.2 35.7 28.9 67.5 26.5 86.2 26.0 37.2 38.1 28.8 24.5 37.9 68.5 41.4 65.1 49.9 54.8 104.8 58.9 43.6 32.7 33.2 27.0 28.8 65.4 30.9 37.8 46.8 42.6 40.6 42.8 39.5 59.5 30.0 42.3 38.1 35.3 56.1 39.7 20.8 31.0 31.8 121.4 30.6 64.5 29.0 21.9 29.4 32.7 41.7 39.6 33.1 27.7 37.8 62.6 98.6 55.1 31.2 49.7 147.1 33.2 31.6 40.0 75.8 34.8 29.4 34.5 50.8 32.5 60.8 42.7 32.9 30.2 29.8 30.7 34.2 29.5 64.6 72.2 24.5 40.9 34.0 32.8 65.1 41.4 46.3 59.4 46.2 37.9 44.8 47.1 66.8 29.9 35.9 43.0 23.5 49.9 56.6 68.5 54.8 104.8 26.7 38.8 24.2 35.0 30.5 27.6 30.1 36.8 31.8 26.5 PSMA7 "C6, HSPC, RC6-1, XAPC7" ENSG00000101182 "Proteasome subunit alpha 7" O14818 20 62136735-62143440 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Host-virus interaction" "Hydrolase, Protease, Threonine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB046007, CAB046008, HPA047266" Approved 26000000 "CAB046007: AB_11128404, CAB046008: AB_2171861, HPA047266: " "unprognostic (1.49e-2)" "unprognostic (4.44e-2)" "unprognostic (1.78e-2)" "unprognostic (2.79e-2)" "unprognostic (6.36e-1)" "unprognostic (6.57e-3)" "prognostic unfavourable (2.54e-5)" "unprognostic (8.82e-2)" "unprognostic (1.87e-2)" "unprognostic (5.06e-3)" "unprognostic (1.16e-1)" "unprognostic (7.30e-2)" "unprognostic (7.04e-2)" "unprognostic (2.31e-1)" "unprognostic (2.21e-2)" "unprognostic (6.31e-2)" "unprognostic (1.98e-2)" 45.1 40.2 26.5 35.0 28.0 56.1 53.1 23.8 30.7 23.2 34.2 21.1 25.4 32.1 33.3 26.6 36.6 26.4 27.3 64.7 26.3 25.7 36.0 63.6 32.8 36.0 28.4 27.0 28.0 48.0 17.1 21.5 27.9 25.0 27.7 27.6 20.7 25.7 27.7 130.5 26.2 33.1 36.9 24.7 34.8 29.7 16.1 22.6 37.2 33.0 53.4 36.8 36.1 44.0 92.3 112.0 124.4 111.2 64.3 114.6 153.5 56.2 69.9 43.1 44.8 39.8 30.6 39.8 44.2 36.2 108.9 46.0 183.0 53.0 46.8 103.1 44.3 67.6 40.2 78.4 54.3 29.3 31.0 104.9 70.5 92.3 49.4 44.6 61.6 32.7 64.1 56.2 50.0 53.9 46.0 44.8 47.2 57.7 71.5 71.3 36.2 101.1 49.9 81.3 50.7 41.6 53.1 58.1 35.7 66.5 82.6 71.1 49.6 67.6 43.8 96.9 79.9 50.9 65.7 32.1 49.3 55.1 67.6 34.3 56.3 98.4 111.2 124.4 93.3 109.7 79.2 92.3 93.7 92.0 102.8 83.7 74.7 77.5 94.4 64.3 109.7 112.0 114.6 153.5 26.5 28.0 23.8 30.7 26.3 25.7 28.4 27.0 25.0 22.6 PSMA8 "MGC26605, PSMA7L" ENSG00000154611 "Proteasome subunit alpha 8" Q8TAA3 18 26133852-26193355 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Hydrolase, Protease, Threonine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 6 "testis: 36.5" "Group enriched" "Detected in some" 95 "Daudi: 23.4;U-266/70: 14.5;U-266/84: 15.1" "Not detected" "Not detected" "Not detected" "Not detected" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected" "Not detected" "unprognostic (5.39e-3)" "unprognostic (7.45e-5)" "unprognostic (2.94e-1)" "unprognostic (3.04e-2)" "unprognostic (1.59e-1)" "unprognostic (2.72e-1)" "unprognostic (1.99e-1)" "unprognostic (8.30e-2)" "unprognostic (7.54e-4)" "unprognostic (4.80e-2)" "unprognostic (1.15e-1)" "unprognostic (2.56e-1)" 0.1 0.1 0.1 1.2 0.1 0.0 0.1 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.1 0.1 0.1 0.0 0.0 0.0 1.6 0.1 0.0 0.1 0.0 0.0 0.1 0.2 0.7 0.1 0.0 0.0 0.1 0.0 0.1 0.0 0.2 0.0 0.1 1.1 0.0 36.5 0.2 0.7 0.1 0.0 2.2 0.1 0.0 4.0 1.9 0.2 0.1 1.2 5.8 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 23.4 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 14.5 15.1 0.1 0.0 0.0 0.0 0.0 0.1 0.0 2.0 0.1 2.2 4.0 2.1 3.9 0.3 3.1 2.4 5.8 0.2 1.2 0.1 1.9 4.3 1.4 0.1 0.1 0.0 0.1 0.1 0.1 0.1 0.0 0.7 0.2 PSMB1 "HC5, PMSB1" ENSG00000008018 "Proteasome subunit beta 1" P20618 6 170535117-170553341 "Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins" "Host-virus interaction" "Hydrolase, Protease, Threonine protease" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA029635, HPA029637, CAB033911" Enhanced Supported Nucleoplasm 14000000 Nucleoplasm "CAB033911: AB_2268890, HPA029635: AB_10599738, HPA029637: AB_10601793" "unprognostic (2.78e-2)" "unprognostic (3.10e-2)" "unprognostic (6.73e-2)" "unprognostic (1.34e-1)" "unprognostic (1.20e-1)" "unprognostic (5.41e-3)" "unprognostic (2.36e-2)" "unprognostic (3.32e-2)" "unprognostic (8.39e-2)" "unprognostic (4.28e-2)" "unprognostic (3.07e-1)" "unprognostic (1.09e-1)" "prognostic unfavourable (3.76e-6)" "unprognostic (3.63e-1)" "unprognostic (7.50e-2)" "unprognostic (1.45e-3)" "unprognostic (9.62e-2)" 60.8 59.3 38.5 40.4 53.7 53.2 55.0 31.4 46.4 40.5 48.6 37.9 49.9 45.1 56.8 90.6 51.7 49.8 43.1 71.9 40.9 40.1 56.4 93.2 46.9 66.7 40.8 41.1 43.7 67.3 35.4 48.4 80.6 48.4 40.6 52.7 43.8 43.6 50.0 109.3 56.1 46.0 59.7 44.9 51.4 46.9 47.1 38.1 47.1 47.9 75.2 60.4 50.1 42.0 71.0 98.1 51.9 81.9 71.6 79.3 104.1 42.5 40.0 57.1 73.6 51.1 40.2 60.8 40.8 60.0 68.0 69.6 87.5 36.8 62.3 53.2 54.5 43.1 63.3 64.8 71.0 63.4 71.2 53.2 40.6 109.7 60.0 62.4 47.5 45.8 39.9 65.6 42.6 58.0 105.0 53.5 62.0 114.6 46.7 87.1 52.1 55.1 45.2 45.3 79.0 70.5 25.6 57.1 46.6 39.2 60.9 31.2 41.7 90.4 44.1 27.7 44.5 67.3 75.3 45.8 60.6 77.4 64.7 70.7 59.4 40.1 81.9 51.9 53.2 75.8 62.1 71.0 62.2 57.7 98.1 53.4 59.2 57.2 47.5 71.6 67.6 55.8 79.3 104.1 38.5 53.7 31.4 46.4 40.9 40.1 40.8 41.1 48.4 38.1 PSMB10 "beta2i, LMP10, MECL1, MGC1665" ENSG00000205220 "Proteasome subunit beta 10" P40306 16 67934502-67937087 "Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins" "Host-virus interaction" "Hydrolase, Protease, Threonine protease" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "blood: 117.3" "Cell line enhanced" "Detected in many" "REH: 36.0;U-266/70: 40.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "HPA030224, HPA030225, CAB034384" Enhanced Supported Vesicles,Cytosol 1400000 Cytosol Vesicles "CAB034384: AB_2171876, HPA030224: , HPA030225: AB_10603231" "unprognostic (1.18e-2)" "unprognostic (1.90e-3)" "unprognostic (2.00e-1)" "unprognostic (2.53e-3)" "unprognostic (2.00e-1)" "unprognostic (1.85e-2)" "unprognostic (7.22e-2)" "unprognostic (3.35e-2)" "unprognostic (1.07e-1)" "unprognostic (2.60e-1)" "unprognostic (8.22e-2)" "unprognostic (1.79e-1)" "unprognostic (1.32e-2)" "unprognostic (2.97e-2)" "unprognostic (1.98e-1)" "unprognostic (1.32e-2)" "prognostic favourable (5.44e-4)" 11.5 13.0 9.1 24.9 11.8 23.9 11.4 4.0 7.8 8.0 21.6 5.6 8.5 42.4 9.3 9.5 10.6 12.4 16.6 12.0 6.9 4.9 16.9 17.2 19.5 38.3 9.5 5.6 8.7 61.5 0.9 6.9 11.2 8.5 13.5 6.3 5.8 27.9 11.6 6.9 7.0 35.6 7.7 6.5 49.7 23.8 2.5 7.8 39.2 13.1 10.4 20.5 13.2 8.4 50.8 75.2 100.0 98.1 69.1 68.8 117.3 5.9 5.3 0.4 0.8 0.4 3.5 21.0 2.0 8.5 6.9 9.8 2.7 29.1 21.6 3.7 2.7 8.7 0.1 1.9 0.5 9.6 0.5 7.7 1.8 3.0 12.0 14.3 23.6 5.3 1.2 3.0 0.0 4.0 0.7 8.3 1.9 7.4 28.1 14.7 0.3 2.0 36.0 2.2 29.5 4.7 10.4 0.3 0.4 6.7 11.8 2.6 2.4 31.0 6.7 4.4 1.2 1.9 2.3 40.3 7.2 14.4 10.9 18.7 9.5 57.1 89.4 67.1 68.8 98.1 50.2 50.8 54.0 57.3 74.6 49.1 45.3 50.1 100.0 69.1 71.4 75.2 60.8 117.3 9.1 11.8 4.0 7.8 6.9 4.9 9.5 5.6 8.5 7.8 PSMB11 beta5t ENSG00000222028 "Proteasome subunit beta 11" A5LHX3 14 23042167-23044276 "Enzymes, Predicted intracellular proteins" "Hydrolase, Protease, Threonine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Tissue enriched" "Detected in some" 13 "lymphoid tissue: 32.7" "Cell line enriched" "Detected in single" 4 "PC-3: 1.8" "Not detected" "Not detected" "Not detected" "Not detected" "Cell type enriched" "Detected in single" 6 "naive CD4 T-cell: 2.1" "Lineage enriched" "Detected in single" 21 "T-cells: 2.1" "Region enriched" "Detected in single" 7 "olfactory region: 2.3" "Not detected" "Not detected" "HPA028967, HPA056970" Enhanced "HPA028967: AB_2732444, HPA056970: AB_2683293" "unprognostic (7.96e-2)" "unprognostic (2.77e-1)" 0.0 0.0 0.1 0.1 0.1 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.2 0.1 0.0 0.1 0.0 0.3 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 2.4 0.0 32.7 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 1.8 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.2 0.1 0.0 0.1 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 2.1 0.3 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.1 0.0 0.0 0.2 0.1 0.1 0.0 0.0 0.0 PSMB2 HC7-I ENSG00000126067 "Proteasome subunit beta 2" P49721 1 35599544-35641844 "Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins" "Host-virus interaction" "Hydrolase, Protease, Threonine protease" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA026322, HPA026324" Approved Enhanced Nucleoplasm 15000000 Nucleoplasm "HPA026322: AB_1855821, HPA026324: AB_1855822" "unprognostic (3.54e-2)" "unprognostic (8.53e-2)" "unprognostic (1.63e-3)" "unprognostic (6.93e-2)" "unprognostic (6.41e-2)" "unprognostic (1.37e-1)" "prognostic unfavourable (3.49e-7)" "unprognostic (2.81e-2)" "unprognostic (5.23e-2)" "unprognostic (3.34e-3)" "unprognostic (7.87e-2)" "unprognostic (4.45e-1)" "prognostic unfavourable (2.80e-6)" "unprognostic (1.65e-1)" "unprognostic (2.83e-1)" "unprognostic (3.77e-2)" "unprognostic (2.93e-2)" 26.5 30.5 29.4 28.0 35.1 37.2 25.3 20.1 50.9 23.2 26.1 35.9 15.4 27.5 27.8 25.0 30.4 26.5 20.7 23.8 30.6 33.4 27.9 63.8 24.6 30.4 30.6 24.8 22.7 24.6 22.0 21.8 37.5 32.6 23.1 27.8 22.8 23.0 24.9 54.7 28.2 27.0 28.7 32.5 29.3 22.8 23.5 21.5 42.8 22.7 29.1 34.0 23.9 22.4 24.6 30.2 19.4 35.3 25.1 28.1 25.4 40.6 25.5 27.8 19.0 14.8 17.8 35.2 19.3 22.7 39.8 32.5 30.2 48.9 40.6 45.3 22.7 25.3 35.8 32.0 33.5 33.1 33.2 36.8 27.9 29.5 26.7 38.6 21.7 19.4 20.3 47.5 23.1 31.2 43.9 23.2 25.6 18.7 50.2 28.9 37.2 27.1 31.1 28.4 28.6 27.6 22.0 24.7 18.2 22.1 20.9 29.8 15.4 17.6 21.5 19.9 23.5 18.8 45.5 20.0 32.2 41.1 29.5 40.7 34.5 17.4 27.0 19.4 23.1 33.0 23.4 24.6 23.1 24.2 29.7 19.3 16.7 20.9 9.7 25.1 35.3 30.2 28.1 25.4 29.4 35.1 20.1 50.9 30.6 33.4 30.6 24.8 32.6 21.5 PSMB3 "HC10-II, MGC4147" ENSG00000277791 "Proteasome subunit beta 3" P49720 17 38752736-38764231 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Host-virus interaction" "Hydrolase, Protease, Threonine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "blood: 99.0" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA042775, HPA048147" Approved 28000000 "HPA042775: , HPA048147: " "unprognostic (1.86e-1)" "unprognostic (4.84e-3)" "unprognostic (1.44e-1)" "unprognostic (4.80e-2)" "unprognostic (6.68e-2)" "unprognostic (1.14e-3)" "unprognostic (5.46e-2)" "unprognostic (2.46e-2)" "unprognostic (2.02e-1)" "unprognostic (1.75e-2)" "unprognostic (3.65e-1)" "unprognostic (1.13e-1)" "prognostic unfavourable (1.71e-6)" "unprognostic (4.44e-1)" "unprognostic (1.28e-1)" "unprognostic (2.42e-3)" "unprognostic (6.03e-2)" 13.3 9.6 5.2 9.9 8.6 13.3 10.3 3.0 13.9 8.5 11.8 7.5 6.4 9.2 5.6 15.3 14.7 10.3 9.8 15.6 4.4 21.6 36.8 11.6 13.0 8.4 7.1 9.6 11.3 7.3 5.7 17.2 8.5 10.8 12.0 9.1 8.5 10.0 22.2 10.0 14.1 11.0 4.7 17.5 7.2 8.5 7.0 23.3 16.7 12.2 15.6 10.2 5.6 32.7 55.0 99.0 56.5 29.1 43.1 63.7 27.7 52.2 21.7 33.5 24.1 19.0 27.7 18.3 31.1 64.4 56.8 62.4 36.1 31.9 33.0 27.3 47.9 35.8 35.4 39.9 41.7 62.8 20.5 30.3 64.7 12.0 32.8 31.6 19.8 21.9 48.4 16.4 34.7 33.0 36.3 31.0 36.3 51.0 51.1 29.3 39.0 28.9 43.9 50.0 37.5 28.4 26.8 17.7 23.5 17.8 22.7 41.0 38.2 18.3 16.9 31.2 35.9 46.7 23.7 40.3 41.3 33.5 32.5 29.6 41.1 56.5 47.4 30.3 49.7 27.9 32.7 28.5 27.6 55.0 28.1 23.0 24.8 99.0 29.1 39.9 53.2 43.1 63.7 PSMB4 "HN3, PROS26" ENSG00000159377 "Proteasome subunit beta 4" P28070 1 151399534-151401944 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Host-virus interaction" "Hydrolase, Protease, Threonine protease" "Disease mutation" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA006700 Approved 15000000 "HPA006700: AB_1079704" "unprognostic (1.11e-1)" "unprognostic (1.44e-1)" "unprognostic (2.69e-1)" "unprognostic (2.52e-1)" "unprognostic (1.63e-1)" "unprognostic (5.74e-2)" "prognostic unfavourable (7.45e-4)" "unprognostic (2.27e-1)" "unprognostic (1.69e-1)" "unprognostic (4.37e-3)" "unprognostic (3.73e-1)" "unprognostic (3.77e-1)" "prognostic unfavourable (2.90e-10)" "unprognostic (5.33e-2)" "unprognostic (2.46e-2)" "unprognostic (3.82e-2)" "unprognostic (5.85e-2)" 45.7 64.5 47.4 40.4 49.5 40.2 56.3 39.6 84.0 44.4 44.3 28.5 58.8 41.2 53.5 65.3 55.7 51.2 37.8 66.6 47.0 50.7 57.3 71.9 43.6 81.1 49.2 61.0 52.4 87.0 40.0 45.4 50.9 48.4 42.6 47.5 37.8 46.7 56.1 68.7 45.7 39.7 66.4 55.1 46.6 43.4 31.8 36.3 51.1 46.8 63.3 62.2 58.6 37.7 68.5 106.5 58.6 81.4 72.5 89.0 78.3 51.2 53.8 45.8 54.9 51.9 49.5 63.0 30.2 66.1 88.3 62.0 71.9 69.3 46.7 91.8 50.6 51.5 46.4 56.9 50.5 65.1 47.0 32.3 40.3 53.8 56.1 44.9 44.4 54.0 54.4 83.0 34.1 61.6 52.1 91.4 62.2 137.3 53.9 52.9 117.2 69.7 51.7 33.5 82.4 72.2 41.9 50.9 60.5 35.2 76.9 101.2 69.5 71.2 39.0 38.8 41.3 41.2 66.4 91.1 104.3 90.0 57.3 40.0 81.6 54.6 81.4 49.5 63.9 75.2 75.9 68.5 74.9 72.5 96.4 60.8 65.8 68.0 58.6 72.5 56.9 106.5 89.0 78.3 47.4 49.5 39.6 84.0 47.0 50.7 49.2 61.0 48.4 36.3 PSMB5 "MB1, X" ENSG00000100804 "Proteasome subunit beta 5" P28074 14 23016543-23035230 "Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins" "Host-virus interaction" "Hydrolase, Protease, Threonine protease" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA049518, HPA061796" Approved Supported Nucleoplasm,Centrosome 8200000 "Nucleoplasm, Centrosome" "HPA049518: , HPA061796: " "unprognostic (3.03e-1)" "unprognostic (1.99e-2)" "unprognostic (8.35e-2)" "unprognostic (6.13e-2)" "unprognostic (1.24e-1)" "prognostic unfavourable (2.85e-4)" "prognostic unfavourable (2.90e-5)" "unprognostic (2.55e-2)" "unprognostic (9.95e-2)" "prognostic favourable (1.08e-4)" "unprognostic (2.06e-1)" "unprognostic (1.19e-1)" "unprognostic (5.30e-2)" "unprognostic (1.75e-1)" "unprognostic (1.95e-1)" "unprognostic (4.95e-2)" "prognostic unfavourable (4.73e-4)" 28.1 38.8 33.6 19.3 35.5 9.6 29.0 19.4 42.9 24.7 28.3 26.8 25.4 21.0 24.2 49.2 31.6 31.6 22.0 37.7 32.9 33.3 35.3 45.4 20.6 18.3 37.5 35.4 22.2 36.6 35.4 26.6 32.5 33.9 27.2 32.2 21.1 28.4 28.7 101.2 22.3 17.2 34.9 32.5 16.7 25.1 27.6 27.3 15.7 29.0 47.3 22.7 20.6 25.2 32.3 53.4 24.6 39.9 19.4 46.8 39.5 22.1 47.1 33.7 31.9 45.4 39.2 33.3 31.6 37.6 55.8 47.4 39.6 35.2 27.5 29.5 42.9 30.2 53.8 39.4 53.9 16.8 37.2 17.4 34.4 139.6 35.9 21.1 21.0 43.7 37.0 41.3 34.5 57.6 26.2 15.6 45.6 65.1 12.0 29.0 37.4 76.4 16.2 25.4 18.3 43.3 32.1 43.0 33.5 22.2 45.2 30.3 21.8 27.5 30.9 27.3 27.8 25.2 31.0 13.5 26.8 20.6 21.3 17.1 33.8 24.6 39.9 17.3 29.3 39.0 34.2 32.3 35.1 28.1 42.6 30.1 46.8 35.6 15.5 19.4 27.9 53.4 28.7 39.5 33.6 35.5 19.4 42.9 32.9 33.3 37.5 35.4 33.9 27.3 PSMB6 "DELTA, Y" ENSG00000142507 "Proteasome subunit beta 6" P28072 17 4796144-4798503 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Host-virus interaction" "Hydrolase, Protease, Threonine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA023312, HPA063656" Supported Supported Nucleoplasm,Cytosol 2800000 Nucleoplasm Cytosol "HPA023312: AB_1855828, HPA063656: " "unprognostic (2.71e-1)" "unprognostic (1.86e-2)" "unprognostic (2.75e-1)" "unprognostic (3.32e-3)" "unprognostic (8.80e-2)" "unprognostic (1.44e-1)" "unprognostic (2.73e-1)" "unprognostic (2.22e-2)" "unprognostic (2.37e-1)" "unprognostic (2.64e-2)" "unprognostic (1.98e-2)" "unprognostic (7.47e-2)" "prognostic unfavourable (5.93e-4)" "unprognostic (1.81e-1)" "unprognostic (2.34e-1)" "unprognostic (5.27e-2)" "unprognostic (5.66e-2)" 28.6 35.0 33.7 23.2 36.4 31.7 34.0 24.2 41.5 29.6 31.7 26.7 26.8 22.6 33.4 47.1 41.9 30.3 24.2 72.0 30.4 30.5 41.4 67.1 25.7 35.3 33.4 34.0 25.3 41.8 40.8 26.6 49.6 35.9 26.4 36.1 23.5 30.6 36.6 97.4 33.6 23.2 40.5 29.7 29.0 31.2 27.0 28.0 35.8 34.6 53.8 39.6 27.9 26.0 93.9 96.3 51.1 95.3 60.4 81.2 107.9 46.0 80.6 43.5 37.1 37.1 33.4 50.2 24.4 51.1 74.7 58.6 59.9 37.6 35.8 48.5 58.4 46.7 66.1 68.4 72.9 46.6 69.7 21.2 53.0 69.6 42.8 21.9 33.9 31.5 52.5 65.2 62.1 72.5 32.4 54.5 57.2 54.8 38.7 36.6 36.9 56.0 43.4 30.9 47.4 56.0 31.1 25.5 31.3 35.0 27.4 25.1 33.4 24.6 34.5 36.9 27.9 49.5 59.0 22.8 30.3 21.8 52.8 40.1 44.3 51.1 95.3 50.5 57.1 87.5 57.8 93.9 62.3 62.6 96.3 79.8 53.7 56.1 32.9 60.4 78.0 89.7 81.2 107.9 33.7 36.4 24.2 41.5 30.4 30.5 33.4 34.0 35.9 28.0 PSMB7 ENSG00000136930 "Proteasome subunit beta 7" Q99436 9 124353466-124415444 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Host-virus interaction" "Hydrolase, Protease, Threonine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA052408, HPA054902" Supported Supported Nucleoplasm,Cytosol 2700000 Nucleoplasm Cytosol "HPA052408: , HPA054902: " "unprognostic (7.75e-2)" "unprognostic (1.83e-2)" "unprognostic (1.27e-1)" "unprognostic (3.64e-3)" "unprognostic (2.83e-1)" "unprognostic (1.25e-1)" "unprognostic (2.02e-2)" "unprognostic (2.24e-3)" "unprognostic (9.03e-2)" "unprognostic (3.60e-1)" "unprognostic (2.99e-1)" "unprognostic (1.78e-1)" "unprognostic (1.26e-2)" "unprognostic (1.67e-1)" "unprognostic (3.45e-1)" "unprognostic (1.93e-3)" "unprognostic (3.98e-2)" 36.9 56.9 51.0 32.8 55.1 53.4 41.9 33.7 52.7 26.6 33.3 34.0 27.9 32.5 33.6 52.1 41.9 32.6 29.2 59.6 44.5 41.3 53.7 87.1 27.0 33.6 43.6 46.9 32.7 67.1 38.5 24.1 53.2 47.3 28.8 37.1 31.1 48.2 26.9 76.7 48.7 32.2 31.4 39.9 28.6 33.1 50.3 36.5 48.2 32.7 67.7 39.5 32.3 30.8 53.4 67.9 45.2 62.7 53.6 66.2 69.0 51.9 63.5 43.5 52.5 30.7 36.7 62.7 50.6 69.8 73.4 50.7 83.4 50.8 59.3 40.9 47.3 74.4 54.1 53.6 67.4 57.0 46.7 37.1 101.0 69.2 69.5 73.6 37.1 43.9 47.3 76.4 76.6 61.5 75.7 42.2 56.6 90.4 52.8 49.5 64.3 90.9 46.8 64.9 69.3 51.9 34.0 51.3 41.8 48.1 61.7 74.9 71.1 32.4 48.7 47.5 38.3 60.6 75.7 45.8 128.3 59.8 79.4 45.4 66.7 40.4 61.7 45.2 41.8 62.7 45.0 53.4 48.1 46.1 67.9 47.5 46.3 44.9 27.3 53.6 58.4 57.8 66.2 69.0 51.0 55.1 33.7 52.7 44.5 41.3 43.6 46.9 47.3 36.5 PSMB8 "beta5i, D6S216E, LMP7, PSMB5i, RING10" ENSG00000204264 "Proteasome subunit beta 8" P28062 6 32840717-32844703 "Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins" "Differentiation, Host-virus interaction, Immunity" "Hydrolase, Protease, Threonine protease" "Disease mutation, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell line enhanced" "Detected in many" "Daudi: 24.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA046995, HPA050327" Enhanced Approved "Vesicles,Cytokinetic bridge" 3300000 Vesicles "Cytokinetic bridge" "HPA046995: AB_2679896, HPA050327: AB_2681088" "prognostic favourable (5.08e-4)" "unprognostic (4.22e-2)" "unprognostic (2.39e-2)" "prognostic favourable (7.16e-4)" "unprognostic (1.92e-1)" "unprognostic (1.68e-1)" "unprognostic (7.78e-2)" "unprognostic (1.09e-1)" "unprognostic (5.71e-2)" "unprognostic (1.17e-2)" "unprognostic (2.79e-2)" "unprognostic (1.47e-1)" "unprognostic (4.14e-2)" "unprognostic (1.24e-1)" "unprognostic (4.35e-2)" "unprognostic (1.97e-3)" "unprognostic (7.11e-3)" 17.0 21.9 7.9 34.8 11.7 14.0 14.9 3.6 7.5 10.0 20.8 5.1 8.8 20.1 12.5 15.3 16.6 13.2 23.8 10.6 6.6 5.7 20.9 30.0 29.0 46.3 9.9 5.1 11.3 12.7 3.6 8.2 9.7 8.8 13.5 24.4 9.2 14.6 11.2 5.1 14.7 37.3 11.5 9.0 42.8 19.4 3.9 9.0 32.2 18.7 18.7 29.0 13.9 12.5 28.9 27.4 37.6 33.2 23.3 29.9 52.2 6.3 2.0 0.1 0.0 2.7 7.0 4.4 1.5 10.1 12.4 17.9 0.0 11.2 24.8 4.8 4.1 4.5 1.4 6.0 3.4 10.2 0.0 10.9 1.3 0.4 14.8 0.2 4.1 7.9 2.8 6.9 2.3 8.4 0.3 5.2 3.1 0.0 5.7 6.0 0.0 1.6 15.5 0.8 12.2 10.1 1.8 0.1 0.1 2.2 5.3 3.3 2.4 20.3 2.5 3.7 1.9 3.5 0.2 8.8 8.3 5.5 1.3 14.3 4.6 19.4 29.0 37.4 25.5 33.2 22.1 28.9 21.7 26.4 27.4 26.3 15.1 21.6 37.6 23.3 28.6 23.3 29.9 52.2 7.9 11.7 3.6 7.5 6.6 5.7 9.9 5.1 8.8 9.0 PSMB9 "beta1i, LMP2, PSMB6i, RING12" ENSG00000240065 "Proteasome subunit beta 9" P28065 6 32844136-32859585 "Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins" "Host-virus interaction, Immunity" "Hydrolase, Protease, Threonine protease" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "blood: 69.1;lymphoid tissue: 54.9" "Cell line enhanced" "Detected in many" "Daudi: 29.1;REH: 21.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "CAB015180, HPA042818, HPA053280" Enhanced Supported Cytosol 420000 Cytosol "CAB015180: AB_2172368, HPA042818: , HPA053280: " "unprognostic (1.09e-2)" "unprognostic (1.68e-2)" "unprognostic (1.26e-2)" "unprognostic (2.18e-3)" "unprognostic (7.84e-2)" "unprognostic (1.89e-1)" "unprognostic (5.68e-2)" "unprognostic (6.67e-2)" "unprognostic (1.56e-2)" "unprognostic (6.50e-3)" "unprognostic (1.87e-3)" "unprognostic (1.84e-1)" "prognostic unfavourable (1.33e-4)" "unprognostic (2.65e-1)" "unprognostic (1.09e-1)" "unprognostic (4.96e-3)" "unprognostic (5.99e-2)" 13.3 9.7 5.0 30.0 7.9 10.7 11.6 1.6 5.3 7.6 16.5 6.0 3.4 15.7 8.8 7.1 10.8 7.4 10.8 8.9 5.1 4.7 12.2 12.2 17.7 32.7 7.3 3.7 9.2 5.4 1.2 4.5 5.5 6.3 12.5 5.8 7.7 9.0 3.5 6.2 7.6 36.1 5.7 9.8 54.9 11.2 3.0 6.7 35.4 14.4 9.3 35.2 15.9 8.8 31.8 17.2 69.1 30.5 23.4 31.1 45.7 0.0 1.4 0.0 0.1 1.1 2.9 2.0 0.2 3.2 4.2 9.7 0.0 9.1 29.1 0.4 2.6 5.9 0.4 6.2 0.5 16.4 0.0 17.7 0.5 1.1 15.7 3.1 1.3 1.3 0.2 2.6 0.4 1.5 0.7 5.4 1.4 0.4 13.4 4.1 0.0 0.9 21.5 0.0 6.9 2.8 0.5 0.0 0.0 2.7 1.7 1.9 2.3 6.5 1.5 4.5 0.4 8.5 2.5 10.1 15.3 9.3 4.6 11.8 3.8 21.9 22.4 39.3 28.7 30.5 23.8 31.8 23.3 27.5 17.2 23.4 17.5 22.9 69.1 23.4 29.4 12.7 31.1 45.7 5.0 7.9 1.6 5.3 5.1 4.7 7.3 3.7 6.3 6.7 PSMD14 "pad1, POH1, Rpn11" ENSG00000115233 "Proteasome 26S subunit, non-ATPase 14" O00487 2 161308038-161411717 "Enzymes, Plasma proteins, Predicted intracellular proteins" "DNA damage, DNA repair, Ubl conjugation pathway" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA002114, HPA003828" Approved Supported Nucleoplasm 9400 Nucleoplasm "HPA002114: AB_1855850, HPA003828: " "unprognostic (3.50e-3)" "unprognostic (1.48e-1)" "unprognostic (9.61e-2)" "unprognostic (6.63e-2)" "unprognostic (2.57e-1)" "unprognostic (7.61e-3)" "prognostic unfavourable (2.66e-8)" "unprognostic (3.11e-2)" "unprognostic (4.04e-2)" "unprognostic (3.90e-3)" "unprognostic (9.84e-3)" "unprognostic (3.02e-1)" "prognostic unfavourable (3.10e-6)" "unprognostic (2.86e-2)" "unprognostic (4.70e-2)" "unprognostic (3.54e-1)" "unprognostic (1.66e-1)" 18.2 26.3 24.8 19.9 25.0 16.8 19.8 21.0 36.9 14.7 17.9 13.5 11.0 15.0 15.6 16.3 23.7 14.4 12.2 22.3 24.8 26.1 23.5 33.7 16.2 24.9 26.2 16.1 11.8 15.0 18.6 24.3 21.5 27.9 16.8 21.9 13.0 15.1 16.7 60.8 16.7 14.3 20.6 26.0 20.2 13.6 19.0 15.3 22.1 18.2 21.6 25.6 15.2 13.1 22.9 27.2 13.1 24.6 23.6 29.6 24.7 35.2 30.7 34.6 30.3 25.2 21.5 42.3 37.2 35.8 53.2 43.4 45.1 30.1 41.9 56.7 27.0 27.2 37.6 39.3 53.3 43.6 28.3 41.8 24.9 50.6 31.0 40.5 24.9 16.4 29.8 60.1 56.2 39.5 45.3 30.2 44.2 33.7 29.8 30.6 48.0 46.6 25.8 33.6 40.9 46.8 30.3 30.1 22.1 25.2 28.5 34.3 19.4 26.1 31.2 35.7 33.6 24.2 40.5 18.1 48.8 39.4 38.3 27.0 39.2 13.1 17.9 8.8 25.3 24.6 26.5 22.9 27.4 27.0 27.2 19.1 22.2 26.5 1.9 23.6 19.1 26.7 29.6 24.7 24.8 25.0 21.0 36.9 24.8 26.1 26.2 16.1 27.9 15.3 PSMD7 "MOV34, P40, Rpn8, S12" ENSG00000103035 "Proteasome 26S subunit, non-ATPase 7" P51665 16 74296775-74306288 "Enzymes, Predicted intracellular proteins" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB019379, HPA049824, HPA056069" Enhanced Enhanced Nucleoplasm 340000 Nucleoplasm "CAB019379: , HPA049824: AB_2680899, HPA056069: AB_2683025" "unprognostic (4.75e-3)" "unprognostic (1.30e-1)" "unprognostic (2.84e-2)" "unprognostic (6.95e-2)" "unprognostic (7.62e-2)" "prognostic unfavourable (6.64e-5)" "prognostic unfavourable (7.71e-6)" "unprognostic (1.97e-2)" "unprognostic (6.51e-2)" "unprognostic (1.91e-2)" "unprognostic (9.34e-3)" "unprognostic (1.34e-2)" "unprognostic (2.52e-2)" "unprognostic (5.06e-3)" "unprognostic (7.04e-2)" "unprognostic (2.12e-1)" "unprognostic (1.86e-2)" 26.5 30.3 23.6 20.8 32.8 45.7 21.7 21.7 34.4 17.7 26.6 22.4 17.0 19.8 24.3 26.1 31.5 16.9 17.6 59.0 22.0 21.7 25.0 47.8 20.3 23.5 24.9 22.9 17.1 18.8 23.2 17.4 44.1 36.1 30.3 28.3 16.7 22.8 27.1 88.8 30.6 22.3 26.4 25.1 27.1 21.8 20.3 22.4 30.7 18.2 34.4 28.4 34.6 22.3 50.3 71.0 64.7 60.8 44.6 56.5 58.1 27.0 45.0 33.4 17.1 24.2 25.0 42.1 38.0 32.1 46.8 43.4 59.5 37.6 37.0 42.2 30.7 35.0 26.6 34.4 41.8 21.9 29.3 28.6 34.9 45.4 31.9 46.3 48.7 23.0 34.7 42.2 42.3 41.0 42.3 16.4 29.7 66.9 26.5 43.8 36.2 22.6 38.4 21.6 49.1 24.8 40.8 21.3 24.1 36.9 13.9 21.8 29.4 31.8 37.1 28.1 23.6 30.6 28.3 35.2 45.2 107.8 38.3 33.8 29.0 45.6 58.4 64.7 49.8 60.8 48.5 50.3 49.7 52.0 71.0 36.1 48.7 49.9 34.8 44.6 60.2 59.6 56.5 58.1 23.6 32.8 21.7 34.4 22.0 21.7 24.9 22.9 36.1 22.4 RBP3 "D10S64, D10S65, D10S66, RP66" ENSG00000265203 "Retinol binding protein 3" P10745 10 47348371-47357875 "Disease related genes, Enzymes, Potential drug targets, Predicted secreted proteins" Transport "Disease mutation, Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 45 "retina: 135.2" "Group enriched" "Detected in some" 8 "HaCaT: 2.6;HDLM-2: 2.4;SH-SY5Y: 2.0" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "HPA041301, HPA044239" Enhanced "Secreted in other tissues" "HPA041301: , HPA044239: " "unprognostic (3.48e-2)" "unprognostic (4.78e-3)" "unprognostic (1.36e-2)" "unprognostic (4.02e-2)" "unprognostic (1.40e-1)" "unprognostic (1.58e-2)" "unprognostic (5.09e-2)" "unprognostic (5.14e-3)" "unprognostic (7.44e-2)" "unprognostic (1.23e-1)" "unprognostic (4.68e-3)" 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 3.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.1 0.0 0.0 135.2 0.0 0.0 0.0 0.5 1.9 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.0 2.6 0.0 0.0 0.0 2.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.2 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 RCE1 "FACE-2, FACE2, hRCE1, RCE1A, RCE1B" ENSG00000173653 "Ras converting CAAX endopeptidase 1" Q9Y256 11 66842835-66846546 "Enzymes, Predicted membrane proteins" "Hydrolase, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA074124 Approved "HPA074124: " "unprognostic (1.11e-1)" "unprognostic (7.23e-2)" "unprognostic (1.15e-1)" "unprognostic (8.16e-3)" "unprognostic (3.11e-1)" "unprognostic (6.40e-3)" "unprognostic (1.98e-3)" "unprognostic (7.69e-3)" "unprognostic (1.39e-1)" "unprognostic (9.14e-3)" "unprognostic (2.35e-3)" "unprognostic (5.31e-3)" "unprognostic (1.06e-1)" "unprognostic (4.48e-3)" "unprognostic (2.17e-2)" "unprognostic (1.04e-1)" "unprognostic (4.28e-2)" 12.3 9.0 7.6 11.9 9.4 19.5 15.9 27.5 9.4 10.8 13.0 9.2 9.3 11.3 10.9 11.8 15.9 9.6 9.7 5.9 6.6 9.4 13.7 7.4 9.7 17.6 8.9 5.1 13.2 23.9 10.2 12.6 20.8 5.6 13.7 9.5 11.2 14.9 13.9 5.6 22.1 13.0 6.7 5.0 12.0 10.2 17.1 5.4 14.8 14.3 10.5 13.6 9.9 9.9 11.4 22.0 12.2 17.9 10.0 17.1 12.4 10.6 12.0 7.4 6.9 4.6 4.0 16.1 5.7 5.6 8.9 8.1 22.5 23.2 8.1 10.8 5.4 19.3 8.6 8.6 5.2 9.7 9.5 7.2 8.5 8.6 16.4 9.1 10.9 6.5 16.5 10.1 9.0 7.3 9.9 12.8 4.5 20.6 13.2 18.2 21.5 12.3 10.6 5.2 15.8 9.8 5.8 9.1 8.2 8.0 11.2 35.1 13.0 7.9 4.3 12.3 9.2 13.2 8.7 6.9 6.9 8.9 8.3 9.7 8.8 12.2 15.6 10.7 13.7 17.9 12.5 11.4 11.5 17.1 14.4 9.0 9.4 14.3 5.1 10.0 15.3 22.0 4.8 12.4 7.6 9.4 27.5 9.4 6.6 9.4 8.9 5.1 5.6 5.4 REN ENSG00000143839 Renin P00797 1 204154819-204190324 "Candidate cardiovascular disease genes, Disease related genes, Enzymes, FDA approved drug targets, Predicted intracellular proteins, Predicted secreted proteins" "Aspartyl protease, Hydrolase, Protease" "Disease mutation, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 4 "kidney: 63.6" "Cell line enhanced" "Detected in some" "A-431: 2.3;BJ: 4.8;HMC-1: 6.3;RT4: 1.8;SK-BR-3: 4.5" "Cancer enriched" "Detected in many" 8 "renal cancer: 39.4" "Region enriched" "Detected in single" 12 "basal ganglia: 1.2" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in all" "HPA005131, CAB025903" Approved "Secreted to blood" 692000 "CAB025903: , HPA005131: AB_1079174" "unprognostic (4.45e-2)" "unprognostic (3.35e-1)" "unprognostic (1.62e-1)" "unprognostic (8.58e-2)" "unprognostic (2.89e-1)" "unprognostic (1.23e-2)" "unprognostic (1.24e-1)" "unprognostic (1.13e-1)" "unprognostic (7.20e-3)" "unprognostic (1.37e-1)" "unprognostic (1.57e-1)" "prognostic unfavourable (6.45e-5)" "unprognostic (1.22e-1)" "unprognostic (1.70e-1)" "unprognostic (4.98e-2)" "unprognostic (6.49e-2)" 0.4 0.3 0.0 0.0 1.2 0.0 0.5 0.0 0.0 3.1 0.2 0.0 0.8 0.1 4.4 13.5 0.1 0.3 0.0 0.6 0.0 0.0 63.6 0.4 0.3 0.0 0.0 0.0 11.6 0.0 0.0 0.4 14.4 0.0 0.3 0.1 0.4 0.3 0.5 0.0 0.0 0.1 1.0 0.0 0.0 0.0 2.0 0.0 0.0 1.1 0.0 0.2 4.4 0.1 0.0 0.0 0.0 0.0 0.0 0.6 0.0 2.3 0.0 0.0 0.0 0.3 0.0 0.0 4.8 0.9 0.0 0.0 0.1 0.6 0.0 0.3 0.0 0.4 0.0 0.2 0.0 0.0 0.1 0.0 0.0 0.1 0.3 0.0 6.3 0.0 0.0 0.0 0.2 0.0 0.4 0.0 0.2 0.6 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 1.8 0.2 0.1 0.0 4.5 0.2 0.5 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 RHBDD1 DKFZp547E052 ENSG00000144468 "Rhomboid domain containing 1" Q8TEB9 2 226835581-226999215 "Enzymes, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Apoptosis, Differentiation, Spermatogenesis" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell line enhanced" "Detected in many" "U-698: 34.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA013972, HPA057125" Approved Supported "Endoplasmic reticulum" "Endoplasmic reticulum" "HPA013972: AB_2178629, HPA057125: " "unprognostic (1.42e-1)" "unprognostic (5.37e-2)" "unprognostic (3.26e-1)" "unprognostic (5.23e-2)" "unprognostic (2.57e-1)" "unprognostic (2.91e-1)" "unprognostic (1.17e-2)" "unprognostic (2.07e-2)" "unprognostic (1.18e-1)" "unprognostic (9.40e-2)" "unprognostic (4.74e-3)" "unprognostic (4.97e-2)" "unprognostic (1.16e-1)" "unprognostic (1.79e-1)" "unprognostic (1.09e-1)" "unprognostic (9.77e-2)" "unprognostic (3.04e-2)" 12.7 14.8 10.8 16.7 16.0 11.0 13.6 8.3 13.0 13.8 14.3 21.2 9.4 11.0 20.6 16.3 13.6 15.4 12.4 14.5 11.4 9.0 13.6 16.9 12.6 17.7 17.6 11.0 18.8 20.4 18.6 17.1 10.5 13.0 15.7 12.4 13.1 14.3 15.5 13.9 13.0 17.5 15.6 16.5 17.3 13.2 25.6 14.7 56.6 17.3 8.8 18.9 18.7 15.4 19.9 16.6 9.8 15.5 8.8 12.5 8.5 5.1 4.4 4.7 7.2 14.3 14.2 0.0 12.2 9.8 6.0 6.9 3.8 8.9 4.8 10.2 12.3 6.0 0.0 12.7 11.6 12.3 4.9 7.0 2.9 3.4 15.4 7.5 4.1 13.3 18.6 11.5 25.1 4.6 18.9 12.6 6.3 9.8 12.7 3.8 0.0 4.7 5.5 0.0 7.0 4.9 6.2 4.6 3.5 6.7 2.4 9.0 6.8 8.6 6.1 2.8 6.2 10.5 3.5 14.1 6.6 34.7 8.9 9.1 8.0 8.1 11.1 9.8 6.1 15.5 9.7 17.3 9.6 7.5 13.7 19.9 10.8 8.9 2.5 8.8 10.3 16.6 12.5 8.5 10.8 16.0 8.3 13.0 11.4 9.0 17.6 11.0 13.0 14.7 RHBDD2 "NPD007, RHBDL7" ENSG00000005486 "Rhomboid domain containing 2" Q6NTF9 7 75842602-75888926 "Enzymes, Predicted membrane proteins" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA045074, HPA051960" Uncertain Enhanced "Golgi apparatus" "Golgi apparatus" "HPA045074: AB_10965705, HPA051960: AB_2681673" "unprognostic (2.75e-1)" "unprognostic (3.89e-2)" "prognostic unfavourable (3.31e-5)" "unprognostic (9.79e-2)" "prognostic unfavourable (1.81e-4)" "unprognostic (2.05e-2)" "unprognostic (1.18e-2)" "unprognostic (2.37e-3)" "unprognostic (1.55e-1)" "unprognostic (2.75e-1)" "unprognostic (5.11e-2)" "unprognostic (1.87e-2)" "prognostic favourable (8.68e-6)" "unprognostic (3.73e-1)" "unprognostic (6.53e-2)" "unprognostic (1.89e-1)" "unprognostic (1.03e-1)" 12.3 50.9 44.3 9.2 64.6 12.1 12.1 14.4 68.3 17.9 11.9 18.5 43.8 18.2 8.5 31.8 14.2 22.6 12.5 14.1 48.5 69.1 18.5 21.7 22.1 8.9 33.6 29.9 12.3 23.6 81.3 56.5 10.6 37.1 15.8 9.1 23.0 22.8 57.3 6.0 14.4 12.5 7.0 16.2 9.5 15.3 15.5 10.7 9.5 34.3 4.2 7.6 10.0 9.6 11.1 13.5 76.4 14.0 13.2 27.4 12.2 7.4 24.6 11.1 22.4 6.5 4.2 4.6 4.5 17.8 10.3 8.7 13.3 20.6 2.8 4.0 8.5 12.2 7.3 5.3 3.2 8.5 14.4 2.5 15.5 12.7 17.9 4.2 23.2 9.2 13.1 11.6 5.2 6.6 5.7 18.3 8.7 49.6 8.0 23.7 10.8 14.1 5.9 7.7 21.4 16.9 13.4 14.7 29.3 16.8 35.7 17.1 23.3 8.0 6.2 16.2 13.5 10.6 9.3 15.2 5.3 4.4 16.1 6.7 19.7 76.4 14.0 17.6 18.9 13.9 16.6 11.1 21.3 16.7 13.5 10.8 18.0 15.3 24.0 13.2 7.9 11.1 27.4 12.2 44.3 64.6 14.4 68.3 48.5 69.1 33.6 29.9 37.1 10.7 RHBDF1 "C16orf8, Dist1, EGFR-RS, FLJ2235, iRhom1" ENSG00000007384 "Rhomboid 5 homolog 1" Q96CC6 16 58059-76355 "Enzymes, Predicted intracellular proteins, Predicted membrane proteins" "Protein transport, Transport" "Growth factor binding" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Cell type enhanced" "Detected in single" "intermediate monocyte: 1.7" "Low lineage specificity" "Detected in single" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA077399 Uncertain Vesicles Vesicles "HPA077399: " "unprognostic (2.62e-1)" "unprognostic (2.86e-2)" "unprognostic (4.76e-2)" "unprognostic (4.04e-2)" "unprognostic (1.51e-2)" "unprognostic (3.69e-2)" "unprognostic (5.60e-3)" "unprognostic (4.54e-3)" "unprognostic (4.51e-2)" "unprognostic (1.02e-1)" "unprognostic (7.81e-3)" "unprognostic (2.09e-1)" "prognostic unfavourable (2.49e-5)" "unprognostic (4.81e-2)" "unprognostic (1.87e-1)" "unprognostic (8.36e-2)" "unprognostic (4.22e-2)" 12.7 3.7 6.2 11.5 9.3 0.3 17.7 3.5 6.2 21.8 10.8 6.1 6.7 5.6 13.0 10.4 17.5 10.6 17.2 15.9 7.0 2.8 8.2 3.8 17.8 4.1 6.9 4.9 18.8 9.6 9.8 4.3 26.5 7.3 19.6 5.5 15.9 20.1 13.5 13.4 22.4 7.5 14.6 5.8 6.1 9.2 7.1 3.1 1.2 11.2 15.7 10.1 16.0 19.4 0.0 0.5 0.0 1.7 0.0 0.4 0.0 4.2 6.9 4.0 9.2 15.7 19.5 13.2 11.8 22.2 8.3 8.0 9.4 15.0 0.2 4.9 12.5 13.6 1.9 7.9 1.4 0.1 2.1 0.1 6.9 2.6 17.6 0.1 7.6 16.2 8.3 21.5 3.6 12.6 1.6 0.2 13.1 23.9 0.0 1.3 3.6 5.9 0.1 4.7 0.3 9.3 4.4 0.1 0.9 3.4 13.1 7.3 20.1 1.5 13.2 13.2 9.3 10.2 3.2 0.1 0.2 0.1 9.2 0.2 20.7 0.0 0.0 0.0 0.0 1.7 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 6.2 9.3 3.5 6.2 7.0 2.8 6.9 4.9 7.3 3.1 RHBDF2 "FLJ22341, iRhom2, RHBDL5, RHBDL6, TOC, TOCG" ENSG00000129667 "Rhomboid 5 homolog 2" Q6PJF5 17 76470891-76501790 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Protein transport, Transport" "Growth factor binding" "Disease mutation, Palmoplantar keratoderma" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell line enhanced" "Detected in many" "RPMI-8226: 34.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Not detected" "Not detected" "Low region specificity" "Detected in many" HPA018080 Uncertain "HPA018080: AB_2178634" "unprognostic (1.19e-1)" "unprognostic (8.71e-2)" "unprognostic (1.59e-2)" "unprognostic (5.11e-3)" "unprognostic (4.33e-2)" "unprognostic (1.63e-1)" "unprognostic (2.63e-3)" "unprognostic (9.79e-3)" "unprognostic (2.55e-1)" "unprognostic (1.72e-1)" "unprognostic (4.49e-2)" "unprognostic (1.38e-1)" "prognostic unfavourable (3.96e-11)" "unprognostic (5.24e-2)" "unprognostic (2.14e-2)" "unprognostic (1.61e-2)" "unprognostic (1.14e-1)" 18.7 7.6 11.6 29.1 17.5 25.9 11.2 3.2 11.5 6.7 6.8 16.4 1.8 6.3 5.4 5.0 16.7 7.5 11.0 6.0 12.8 7.1 9.5 5.2 17.1 24.5 18.2 3.8 6.3 18.9 4.7 4.4 9.9 15.3 6.6 4.6 7.0 9.4 4.7 8.9 19.4 18.2 6.0 23.4 31.6 8.5 4.0 15.3 3.5 8.9 8.1 26.8 10.7 10.0 12.5 9.3 10.7 12.2 4.5 8.2 6.5 16.4 18.8 0.6 5.3 0.1 0.4 13.8 4.3 12.9 3.8 4.6 5.5 22.1 17.7 14.3 4.9 13.9 3.1 19.3 3.0 3.1 5.8 1.2 1.3 9.0 12.9 0.7 2.7 2.5 10.1 8.5 9.8 9.5 2.2 8.6 2.2 13.4 1.9 2.0 3.2 11.0 4.6 0.1 34.8 8.4 6.0 4.2 6.1 4.2 14.3 18.6 11.8 5.0 14.3 0.3 7.1 0.3 4.8 21.3 10.0 14.9 11.7 5.4 12.8 3.9 11.6 3.7 8.2 12.2 5.7 12.5 2.3 5.8 5.9 7.7 1.4 3.4 10.7 4.5 10.4 9.3 1.2 6.5 11.6 17.5 3.2 11.5 12.8 7.1 18.2 3.8 15.3 15.3 RHBDL1 "RHBDL, RRP" ENSG00000103269 "Rhomboid like 1" O75783 16 675666-678268 "Enzymes, Predicted membrane proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 21.3" "Cell line enhanced" "Detected in many" "HeLa: 9.1;MCF7: 9.6;U-266/70: 11.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Cell type enhanced" "Detected in some" "memory CD4 T-cell: 3.4" "Group enriched" "Detected in many" 20 "B-cells: 2.2;NK-cells: 1.3;T-cells: 3.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA030359, HPA030360, HPA046593" Uncertain Approved Nucleoplasm Nucleoplasm "HPA030359: , HPA030360: , HPA046593: " "prognostic favourable (8.12e-4)" "unprognostic (1.70e-1)" "unprognostic (7.38e-2)" "unprognostic (4.45e-1)" "unprognostic (2.07e-1)" "unprognostic (1.58e-2)" "unprognostic (3.27e-2)" "unprognostic (1.94e-1)" "unprognostic (2.78e-1)" "unprognostic (6.60e-3)" "unprognostic (2.74e-2)" "unprognostic (3.97e-2)" "unprognostic (5.63e-3)" "unprognostic (5.89e-2)" "unprognostic (1.27e-1)" "unprognostic (8.30e-3)" "unprognostic (1.49e-2)" 1.7 6.3 10.0 1.1 8.3 2.3 0.7 21.3 14.5 1.3 2.2 1.3 2.2 5.8 1.3 1.7 1.1 1.0 1.2 2.4 8.4 9.9 3.9 1.2 0.8 1.1 5.5 7.2 0.9 6.2 2.2 4.4 1.1 4.6 1.5 1.1 1.5 6.1 2.6 0.8 3.1 5.9 0.7 2.2 0.6 4.5 2.2 1.9 0.7 0.6 0.6 0.5 0.8 0.5 2.2 0.1 0.0 0.0 1.3 3.4 0.7 1.7 2.3 1.3 2.0 1.0 2.6 6.7 0.8 1.2 0.4 0.1 4.7 1.3 0.7 1.6 0.5 1.2 0.1 0.4 0.0 1.7 8.5 1.0 9.1 1.9 0.9 1.7 1.3 1.8 3.2 0.3 0.0 0.1 1.3 1.3 0.1 9.6 0.4 4.6 1.2 0.7 8.1 1.2 1.7 0.1 1.6 1.6 2.2 1.0 0.5 2.2 3.5 4.8 0.5 2.8 2.6 0.9 0.6 11.7 1.6 2.3 1.0 3.2 0.2 0.0 0.0 0.0 0.0 0.0 0.0 2.2 3.4 0.3 0.0 0.5 0.5 0.2 0.0 1.3 0.0 0.1 1.2 0.7 10.0 8.3 21.3 14.5 8.4 9.9 5.5 7.2 4.6 1.9 RHBDL2 FLJ20435 ENSG00000158315 "Rhomboid like 2" Q9NX52 1 38885807-38941799 "Enzymes, Predicted membrane proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "esophagus: 18.9" "Cell line enhanced" "Detected in some" "CAPAN-2: 26.0;HaCaT: 13.5;RT4: 26.1" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low region specificity" "Detected in single" "Low region specificity" "Detected in all" HPA043807 Approved "HPA043807: AB_10961118" "unprognostic (3.34e-2)" "unprognostic (2.96e-1)" "unprognostic (4.57e-2)" "unprognostic (2.56e-1)" "unprognostic (7.26e-3)" "unprognostic (2.19e-2)" "unprognostic (1.04e-3)" "unprognostic (5.81e-2)" "unprognostic (2.36e-1)" "unprognostic (2.87e-1)" "unprognostic (4.07e-3)" "unprognostic (1.23e-1)" "unprognostic (7.47e-9)" "unprognostic (1.11e-2)" "unprognostic (2.46e-1)" "unprognostic (4.12e-2)" "unprognostic (4.20e-2)" 1.4 0.0 2.9 6.7 2.7 0.0 1.5 0.4 4.0 5.5 14.9 1.7 0.4 0.7 1.9 0.7 18.9 0.7 6.9 4.9 4.2 2.1 0.5 0.4 2.1 1.5 4.9 0.7 1.2 2.4 0.0 0.4 1.0 1.6 3.1 14.7 0.8 8.2 0.4 0.4 13.4 0.9 0.9 7.9 0.6 12.3 8.4 0.4 1.3 0.4 12.2 16.4 6.9 8.2 1.7 2.1 5.3 1.7 0.9 0.9 0.7 8.0 3.2 0.2 0.1 0.1 1.0 0.9 0.4 0.1 0.6 0.0 0.5 26.0 0.2 1.9 3.7 13.5 0.0 4.8 0.3 0.1 0.1 0.1 2.0 1.7 0.5 0.0 0.3 0.6 0.6 3.9 0.0 0.8 0.0 0.2 0.5 0.0 0.0 0.1 0.2 0.7 0.1 0.1 0.0 0.0 26.1 0.2 0.1 2.8 6.6 0.2 3.4 0.2 0.5 2.9 0.3 0.2 0.2 0.2 0.3 0.3 2.5 0.4 0.1 3.6 1.7 1.1 0.8 1.1 0.4 1.7 0.6 0.5 1.9 1.1 0.7 0.7 5.3 0.9 0.7 2.1 0.9 0.7 2.9 2.7 0.4 1.5 4.2 2.1 4.9 0.7 1.6 0.4 RHBDL3 "RHBDL4, VRHO" ENSG00000141314 "Rhomboid like 3" P58872 17 32266176-32324661 "Enzymes, Predicted membrane proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 23.7" "Cell line enhanced" "Detected in some" "A549: 5.9;AF22: 5.9;AN3-CA: 4.7;HDLM-2: 8.1;NTERA-2: 8.8;U-2 OS: 6.2" "Cancer enhanced" "Detected in some" "glioma: 4.3" "Low region specificity" "Detected in all" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" HPA059607 Uncertain "HPA059607: " "unprognostic (7.70e-2)" "unprognostic (3.71e-2)" "unprognostic (2.36e-2)" "unprognostic (6.95e-2)" "unprognostic (2.91e-1)" "unprognostic (2.83e-2)" "unprognostic (2.22e-1)" "unprognostic (1.93e-1)" "unprognostic (1.85e-3)" "unprognostic (1.13e-1)" "unprognostic (1.82e-3)" "unprognostic (1.75e-2)" "unprognostic (4.19e-2)" "unprognostic (2.18e-3)" "unprognostic (2.11e-1)" "unprognostic (1.23e-1)" "unprognostic (8.87e-2)" 1.0 8.2 6.8 1.2 7.4 0.7 1.1 11.3 23.7 1.4 1.2 2.9 3.3 0.9 2.0 1.9 1.3 4.4 0.9 9.7 10.1 6.6 0.8 0.6 0.7 0.7 9.1 4.6 3.4 1.1 0.6 1.9 1.0 6.7 2.1 1.4 3.9 1.0 5.6 0.6 0.9 0.9 1.8 3.6 0.6 0.9 2.5 4.0 0.0 0.6 0.0 0.8 1.9 1.1 0.8 0.0 0.0 0.0 0.0 0.3 0.3 0.0 5.9 5.9 4.7 0.9 0.0 0.1 0.3 0.6 1.9 2.0 0.1 0.0 0.0 0.4 0.7 0.1 1.6 0.0 0.5 8.1 2.3 1.0 4.0 0.3 0.0 0.0 0.1 0.0 0.0 1.5 0.0 0.0 0.5 0.0 0.5 0.1 0.2 0.0 8.8 0.0 1.0 0.0 0.0 0.0 3.2 0.1 1.6 0.8 0.1 0.1 0.4 0.1 0.0 0.0 6.2 0.3 3.0 0.0 0.0 0.0 0.3 0.9 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.3 6.8 7.4 11.3 15.6 10.1 6.6 9.1 4.6 6.7 4.0 RNPEP APB ENSG00000176393 "Arginyl aminopeptidase" Q9H4A4 1 201982372-202006147 "Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Aminopeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Group enriched" "Detected in all" 4 "dendritic cells: 12.1;granulocytes: 12.3;monocytes: 17.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" "HPA036074, HPA036075, HPA061487" Approved Supported "Nucleoplasm,Golgi apparatus" "Secreted - unknown location" 6600000 "Golgi apparatus" Nucleoplasm "HPA036074: AB_2674926, HPA036075: AB_10672999, HPA061487: " "unprognostic (8.57e-2)" "unprognostic (3.43e-2)" "unprognostic (2.81e-1)" "unprognostic (5.45e-2)" "unprognostic (2.68e-1)" "unprognostic (1.74e-2)" "unprognostic (1.95e-2)" "unprognostic (2.87e-2)" "unprognostic (1.93e-3)" "unprognostic (1.80e-1)" "unprognostic (1.07e-1)" "unprognostic (1.28e-1)" "unprognostic (3.50e-3)" "unprognostic (1.91e-1)" "unprognostic (6.00e-2)" "unprognostic (1.97e-2)" "unprognostic (1.68e-1)" 18.5 22.0 6.4 14.9 8.2 9.5 16.7 9.2 11.0 17.8 34.2 13.5 21.2 31.1 17.4 18.7 33.2 19.2 21.8 11.5 6.1 4.6 22.5 18.3 21.5 14.1 7.0 5.4 18.0 19.5 11.6 10.4 26.3 9.0 18.4 26.8 16.4 25.1 13.6 10.0 18.3 66.6 12.8 8.1 22.7 15.7 21.2 6.0 13.9 28.4 19.1 24.7 17.6 17.5 2.3 12.1 12.3 17.0 1.6 3.1 2.2 19.0 20.7 12.3 18.5 20.2 19.0 31.1 14.7 28.5 18.4 20.8 14.8 24.4 4.1 18.9 25.8 34.6 15.7 28.7 12.9 11.3 20.3 10.4 9.9 13.9 17.2 26.4 36.8 17.3 29.7 16.4 18.9 33.1 23.6 6.2 18.6 17.4 3.6 11.2 17.4 10.3 13.9 17.4 29.4 38.3 17.3 14.3 12.1 36.3 45.4 14.6 34.5 15.1 23.6 8.7 11.7 8.4 17.8 13.8 11.1 3.7 8.6 22.5 17.3 10.8 9.2 12.3 1.9 15.7 2.6 1.6 2.0 2.2 12.1 2.3 1.8 2.1 6.7 1.6 17.0 4.5 3.1 2.2 6.4 8.2 9.2 11.0 6.1 4.6 7.0 5.4 9.0 6.0 RNPEPL1 ENSG00000142327 "Arginyl aminopeptidase like 1" Q9HAU8 2 240565804-240581372 "Enzymes, Predicted intracellular proteins" "Aminopeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA036772 Uncertain Approved Nucleoplasm,Nucleoli Nucleoplasm Nucleoli "HPA036772: AB_10670848" "unprognostic (3.92e-2)" "unprognostic (7.28e-2)" "unprognostic (1.20e-2)" "unprognostic (2.39e-1)" "unprognostic (5.24e-3)" "prognostic favourable (7.43e-4)" "prognostic unfavourable (5.06e-4)" "unprognostic (3.72e-3)" "unprognostic (9.10e-2)" "unprognostic (1.66e-3)" "unprognostic (3.10e-1)" "unprognostic (1.71e-1)" "unprognostic (1.98e-2)" "unprognostic (5.33e-2)" "unprognostic (1.57e-1)" "unprognostic (5.31e-2)" "unprognostic (9.86e-2)" 17.2 13.7 10.1 13.7 8.8 17.2 48.4 7.2 10.5 11.0 21.0 9.5 11.8 18.6 8.0 8.9 22.1 8.0 22.3 28.3 9.2 6.0 18.2 26.7 32.2 54.1 12.9 8.2 7.1 40.0 7.7 4.3 10.1 8.1 14.9 9.1 7.0 21.5 13.5 26.5 22.5 31.0 11.4 9.7 25.7 20.0 5.9 7.6 23.1 8.8 16.7 12.1 14.4 18.8 7.0 7.6 22.4 9.1 7.6 12.4 5.4 6.8 11.5 2.5 6.8 9.4 9.8 8.7 4.4 11.0 5.0 6.2 3.1 20.2 2.0 2.3 11.1 7.5 2.9 8.2 0.5 12.0 4.0 4.5 3.7 18.6 23.7 2.9 8.2 11.6 13.4 2.6 5.1 17.0 3.3 13.4 3.3 9.7 3.7 11.1 3.4 4.6 7.8 3.8 16.6 20.2 9.5 2.4 5.1 3.0 10.3 20.0 7.2 13.6 11.6 5.4 5.6 7.5 5.0 12.7 1.9 2.3 11.1 8.3 8.1 5.8 9.1 22.4 12.4 7.8 10.6 7.0 9.6 11.1 6.4 6.8 5.4 8.1 16.0 7.6 7.6 7.6 11.1 5.4 10.1 8.8 7.2 10.5 9.2 6.0 12.9 8.2 8.1 7.6 SCPEP1 RISC ENSG00000121064 "Serine carboxypeptidase 1" Q9HB40 17 56978105-57006768 "Enzymes, Predicted intracellular proteins, Predicted secreted proteins" "Carboxypeptidase, Hydrolase, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "parathyroid gland: 113.9" "Cell line enhanced" "Detected in all" "ASC diff: 79.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Cell type enhanced" "Detected in many" "eosinophil: 60.8" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA039102, HPA057200" Enhanced Approved "Golgi apparatus" "Secreted to blood" "Golgi apparatus" "HPA039102: AB_10673605, HPA057200: " "unprognostic (5.83e-3)" "unprognostic (7.43e-3)" "unprognostic (4.47e-2)" "unprognostic (2.96e-1)" "unprognostic (9.26e-2)" "unprognostic (1.43e-2)" "prognostic unfavourable (1.96e-5)" "unprognostic (1.00e-3)" "unprognostic (1.68e-1)" "unprognostic (1.70e-1)" "unprognostic (3.56e-3)" "unprognostic (1.40e-1)" "unprognostic (3.25e-1)" "unprognostic (7.28e-2)" "unprognostic (8.89e-2)" "unprognostic (8.33e-2)" "unprognostic (1.68e-1)" 29.5 54.1 14.7 12.6 10.2 17.8 25.8 8.8 14.8 21.5 17.6 12.8 50.1 8.8 17.5 24.1 25.9 14.6 20.7 25.0 10.2 11.8 24.8 8.7 25.6 24.5 12.2 14.3 19.9 9.4 113.9 13.6 7.6 14.2 24.6 9.5 13.4 31.5 37.6 6.4 17.8 15.9 23.2 13.9 22.3 20.8 7.7 10.8 2.4 62.7 14.1 25.3 24.7 20.8 14.1 23.4 60.8 44.8 4.6 3.0 20.3 9.5 5.8 9.1 8.5 79.3 17.8 5.1 4.6 23.2 8.1 16.2 2.7 6.1 12.9 27.1 10.9 9.3 4.3 20.8 8.6 17.4 7.5 3.8 5.9 1.6 18.1 7.9 39.5 21.5 8.9 10.5 8.1 13.5 1.1 46.4 11.6 4.1 3.6 19.8 4.1 8.5 5.0 11.2 8.3 1.8 29.6 2.8 7.1 11.7 8.8 6.9 4.0 20.3 7.2 24.7 6.6 14.5 5.2 52.4 38.3 7.1 17.3 5.6 6.7 0.3 44.8 60.8 3.0 27.1 1.9 12.9 2.1 1.9 23.4 14.1 2.9 2.9 7.3 4.6 25.3 4.5 2.5 20.3 14.7 10.2 8.8 14.8 10.2 11.8 12.2 14.3 14.2 10.8 SCRN1 KIAA0193 ENSG00000136193 "Secernin 1" Q12765 7 29920103-29990289 "Enzymes, Predicted intracellular proteins" Exocytosis "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 62.8" "Cell line enhanced" "Detected in many" "WM-115: 71.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA024517 Enhanced Approved Cytosol 110000 Cytosol "HPA024517: AB_2184811" "prognostic unfavourable (8.32e-4)" "prognostic unfavourable (8.46e-4)" "unprognostic (1.45e-1)" "prognostic unfavourable (4.00e-5)" "unprognostic (1.87e-2)" "unprognostic (2.43e-1)" "unprognostic (1.13e-3)" "unprognostic (1.10e-1)" "unprognostic (2.29e-1)" "prognostic unfavourable (7.27e-4)" "unprognostic (1.09e-2)" "unprognostic (1.02e-1)" "prognostic favourable (1.15e-5)" "unprognostic (2.57e-2)" "unprognostic (2.10e-1)" "unprognostic (2.23e-1)" "prognostic unfavourable (2.60e-4)" 6.8 14.8 32.0 6.3 31.5 3.6 7.6 62.8 55.4 12.4 8.1 23.2 4.5 3.4 13.3 8.8 10.0 13.9 8.5 9.8 26.6 30.7 12.8 1.5 8.3 6.7 42.7 26.6 17.5 18.5 42.9 12.1 8.0 26.3 15.0 5.6 7.8 8.4 20.2 1.0 5.7 5.0 17.7 42.9 5.2 7.1 11.4 23.3 8.2 7.1 1.5 10.6 9.4 5.8 10.4 7.8 6.9 16.7 4.8 8.1 2.2 22.3 16.2 26.4 10.6 18.8 28.9 0.1 20.9 28.1 22.7 24.6 18.6 17.8 2.7 18.6 26.8 10.1 30.0 8.9 33.3 0.1 6.3 9.3 10.9 12.0 24.0 0.0 0.1 24.0 12.8 20.6 11.1 20.9 0.1 7.3 32.0 12.6 3.2 0.0 24.0 17.4 0.0 28.2 0.2 15.9 11.0 9.7 22.9 21.6 14.1 24.1 18.9 1.4 23.0 29.5 25.5 0.3 26.4 2.4 36.2 0.2 13.9 0.1 71.2 2.2 2.3 6.9 0.6 10.2 8.1 10.4 0.1 0.8 7.7 5.0 0.6 1.0 0.4 4.8 16.7 7.8 0.0 2.2 32.0 31.5 62.8 43.1 26.6 30.7 42.7 26.6 26.3 23.3 SCRN2 ENSG00000141295 "Secernin 2" Q96FV2 17 47837692-47841333 "Enzymes, Predicted intracellular proteins" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA022934, HPA023434" Enhanced Supported "Nucleoplasm,Golgi apparatus" 350000 Nucleoplasm "Golgi apparatus" "HPA022934: AB_1856638, HPA023434: AB_1856639" "unprognostic (2.35e-2)" "unprognostic (1.42e-2)" "unprognostic (2.86e-1)" "unprognostic (6.14e-2)" "unprognostic (2.46e-2)" "unprognostic (1.73e-1)" "prognostic favourable (3.86e-4)" "unprognostic (4.63e-2)" "unprognostic (3.25e-2)" "unprognostic (5.77e-2)" "unprognostic (1.28e-3)" "unprognostic (8.72e-2)" "unprognostic (3.43e-2)" "unprognostic (5.28e-3)" "unprognostic (1.64e-1)" "unprognostic (1.20e-1)" "prognostic favourable (5.83e-4)" 43.4 10.3 8.3 14.2 14.1 6.7 20.8 17.7 13.1 10.6 17.3 11.2 23.6 25.1 11.4 18.1 8.9 15.4 13.3 17.9 8.6 8.9 29.3 17.4 8.3 8.7 8.1 9.6 11.8 25.3 11.4 14.5 7.8 10.5 13.6 6.1 14.8 20.1 19.2 20.0 10.9 20.1 9.7 7.3 15.0 9.8 4.0 10.9 8.5 18.1 9.0 11.0 10.7 10.0 16.9 19.2 25.9 13.4 16.5 22.1 10.8 11.9 19.0 5.3 5.1 15.5 12.0 16.1 6.0 12.3 9.3 9.5 14.2 14.3 6.6 12.2 3.1 6.5 1.7 10.6 3.2 15.8 13.1 6.7 13.9 12.3 5.5 3.1 5.4 11.5 8.0 5.7 4.4 10.4 2.2 7.5 12.7 10.8 10.6 5.5 2.6 7.6 14.2 4.0 26.7 7.4 5.4 4.1 17.1 3.4 7.3 8.0 16.4 6.3 4.8 8.5 9.1 2.3 2.8 31.2 4.0 3.1 23.1 5.6 1.9 12.3 12.8 25.9 16.9 13.4 16.3 16.9 14.0 16.4 16.3 15.6 22.1 12.2 3.2 16.5 6.5 19.2 13.9 10.8 8.3 14.1 17.7 13.1 8.6 8.9 8.1 9.6 10.5 10.9 SCRN3 FLJ23142 ENSG00000144306 "Secernin 3" Q0VDG4 2 174395730-174429575 "Enzymes, Predicted intracellular proteins" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA034689, HPA034690" Approved Approved Vesicles,Cytosol 9300 "Vesicles, Cytosol" "HPA034689: , HPA034690: AB_10670574" "unprognostic (5.39e-3)" "unprognostic (4.58e-2)" "unprognostic (2.06e-2)" "unprognostic (3.58e-1)" "unprognostic (1.91e-1)" "unprognostic (1.89e-1)" "unprognostic (9.89e-2)" "unprognostic (1.57e-1)" "unprognostic (5.14e-2)" "unprognostic (5.85e-2)" "unprognostic (8.81e-2)" "unprognostic (1.30e-1)" "unprognostic (6.62e-3)" "unprognostic (1.75e-1)" "unprognostic (1.31e-1)" "unprognostic (5.57e-2)" "unprognostic (1.57e-1)" 12.4 15.9 19.2 7.6 18.4 3.7 11.4 13.2 27.0 8.4 10.4 16.7 12.5 15.4 10.3 10.1 14.2 9.1 9.4 21.2 20.2 20.0 17.4 18.0 10.1 10.5 23.5 21.1 11.7 12.1 26.6 20.6 10.9 25.9 13.4 11.3 8.7 10.6 12.3 30.3 11.5 11.5 11.8 27.9 9.3 10.2 8.4 20.2 10.4 17.3 6.2 9.5 11.2 9.1 9.9 6.9 18.5 4.6 5.5 7.5 2.2 9.0 5.6 14.5 13.4 11.3 12.8 8.2 14.0 10.8 10.9 13.0 5.5 6.7 1.7 9.2 13.9 9.1 11.2 12.1 14.0 19.7 10.1 16.9 12.2 4.3 17.0 12.9 8.9 14.3 15.1 20.0 14.7 12.5 11.1 6.6 14.7 10.1 10.6 12.5 7.1 23.8 5.3 15.2 9.9 12.1 9.3 9.4 26.5 9.6 9.6 17.6 12.8 12.5 9.1 12.6 6.6 14.8 11.7 17.5 18.1 0.2 13.8 6.4 12.7 4.8 4.6 1.9 4.6 2.7 3.3 7.0 4.7 4.3 4.3 9.9 7.5 5.9 18.5 5.5 3.6 6.9 4.8 2.2 19.2 18.4 13.2 27.0 20.2 20.0 23.5 21.1 25.9 20.2 SEC11A "SEC11L1, sid2895, SPC18, SPCS4A" ENSG00000140612 "SEC11 homolog A, signal peptidase complex subunit" P67812 15 84669538-84716716 "Enzymes, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA047533 Approved "Nuclear membrane,Golgi apparatus" 7400000 "Nuclear membrane" "Golgi apparatus" "HPA047533: " "unprognostic (8.81e-3)" "unprognostic (1.97e-1)" "unprognostic (3.19e-2)" "prognostic favourable (1.94e-5)" "unprognostic (3.39e-2)" "prognostic unfavourable (5.99e-5)" "unprognostic (1.51e-1)" "unprognostic (1.95e-1)" "unprognostic (2.79e-1)" "unprognostic (1.42e-2)" "unprognostic (6.17e-2)" "unprognostic (6.24e-2)" "unprognostic (1.09e-2)" "unprognostic (1.04e-1)" "unprognostic (1.80e-1)" "prognostic favourable (2.95e-4)" "unprognostic (7.89e-2)" 65.5 43.6 18.7 23.3 17.3 36.4 42.6 11.2 15.5 44.4 38.5 23.0 38.8 20.7 41.8 57.9 40.3 27.3 33.2 30.8 18.7 18.4 56.5 68.2 44.7 41.1 24.7 12.6 55.7 70.9 21.2 41.7 46.0 18.4 44.4 28.0 28.5 43.5 36.2 51.9 23.3 33.3 39.7 31.5 38.4 29.5 28.2 19.7 33.2 74.6 39.3 32.1 49.8 37.8 29.1 44.3 32.6 48.4 34.3 45.9 46.3 23.6 51.1 37.7 58.3 47.8 59.7 29.0 37.8 44.1 31.1 37.2 54.7 58.7 11.8 24.9 46.5 51.6 52.3 31.7 33.8 28.9 38.6 34.3 58.2 51.3 41.5 25.8 38.9 41.1 39.9 21.4 34.8 43.9 34.1 31.6 41.9 55.5 10.5 56.1 40.1 22.0 13.2 48.8 38.3 69.8 66.3 18.5 41.6 31.4 35.2 85.1 34.4 60.0 29.9 31.5 23.7 26.9 46.0 31.1 58.9 16.6 34.2 45.5 24.6 20.7 43.8 24.1 28.4 47.3 28.5 29.1 35.4 30.4 43.8 26.6 30.2 30.9 32.6 34.3 48.4 44.3 45.9 46.3 18.7 17.3 11.2 15.5 18.7 18.4 24.7 12.6 18.4 19.7 SEC11C "SEC11L3, SPC21, SPCS4C" ENSG00000166562 "SEC11 homolog C, signal peptidase complex subunit" Q9BY50 18 59139477-59158836 "Enzymes, Predicted membrane proteins" "Hydrolase, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "salivary gland: 132.6" "Cell line enhanced" "Detected in many" "HDLM-2: 58.2;Karpas-707: 62.8;RPMI-8226: 127.1;U-266/70: 64.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA026816, HPA047533" Approved Approved "Nuclear membrane,Golgi apparatus" "Nuclear membrane" "Golgi apparatus" "HPA026816: AB_10602089, HPA047533: " "unprognostic (1.47e-2)" "unprognostic (2.20e-2)" "unprognostic (1.26e-1)" "unprognostic (2.44e-2)" "unprognostic (3.13e-3)" "unprognostic (4.48e-3)" "unprognostic (2.95e-1)" "unprognostic (2.32e-2)" "unprognostic (1.15e-1)" "unprognostic (4.33e-2)" "unprognostic (1.80e-2)" "unprognostic (1.72e-1)" "unprognostic (6.25e-2)" "unprognostic (3.83e-2)" "unprognostic (4.63e-2)" "unprognostic (2.58e-1)" "unprognostic (1.15e-1)" 5.9 18.4 30.1 18.6 29.7 11.3 16.0 14.9 25.2 12.2 18.7 24.4 27.8 27.5 9.1 58.0 10.7 9.2 11.1 7.2 27.7 33.9 19.0 66.8 13.0 22.0 41.8 21.3 7.0 96.8 14.6 46.6 8.1 27.1 48.8 16.4 10.0 132.6 34.1 4.3 7.9 21.1 6.6 51.3 23.6 28.4 6.4 25.3 7.3 35.9 8.6 23.4 18.9 5.9 33.6 50.0 10.6 17.6 17.3 34.4 32.6 8.6 10.4 5.7 8.8 3.5 0.6 7.3 7.9 6.7 9.7 5.9 7.3 4.7 19.9 12.4 4.7 9.3 8.9 5.9 5.6 58.2 12.2 6.4 7.3 22.4 10.6 21.0 9.7 2.0 14.1 6.0 16.2 3.2 7.3 62.8 3.4 10.2 8.6 8.4 5.7 6.4 7.9 5.6 127.1 6.3 7.3 26.6 10.5 4.7 19.1 26.6 8.6 15.5 2.5 11.8 4.9 4.1 9.4 64.0 47.1 19.5 11.7 14.3 14.4 10.6 13.1 9.4 25.9 15.5 33.1 33.6 27.3 25.2 13.5 17.4 14.3 19.5 2.0 17.3 17.6 50.0 34.4 32.6 30.1 29.7 14.9 25.2 27.7 33.9 41.8 21.3 27.1 25.3 SENP1 ENSG00000079387 "SUMO1/sentrin specific peptidase 1" Q9P0U3 12 48042898-48106308 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "testis: 60.2" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA011765, HPA046491" Supported "Nucleoplasm,Focal adhesion sites" Nucleoplasm "Focal adhesion sites" "HPA011765: AB_1079907, HPA046491: " "unprognostic (2.66e-2)" "unprognostic (6.51e-2)" "unprognostic (3.14e-1)" "unprognostic (5.69e-2)" "unprognostic (2.83e-1)" "unprognostic (1.09e-1)" "prognostic unfavourable (7.72e-5)" "unprognostic (6.48e-2)" "unprognostic (2.44e-3)" "unprognostic (8.20e-3)" "unprognostic (2.57e-1)" "unprognostic (2.23e-1)" "prognostic unfavourable (8.37e-4)" "unprognostic (7.61e-2)" "unprognostic (3.02e-1)" "unprognostic (1.01e-1)" "unprognostic (1.28e-1)" 5.7 3.3 3.0 9.0 4.0 8.4 5.2 5.3 3.2 5.5 4.9 3.8 3.5 3.4 6.2 4.3 5.7 5.2 3.8 3.6 2.7 3.3 3.8 3.9 4.3 7.3 3.0 2.3 6.2 4.4 6.1 11.4 8.1 3.0 4.4 4.7 5.1 20.0 4.7 6.8 6.6 4.5 5.8 4.3 6.4 4.5 60.2 3.6 15.0 5.2 4.8 8.3 5.7 6.3 5.3 3.8 7.1 2.6 3.8 5.5 2.3 7.0 9.1 11.3 8.5 3.4 5.0 8.4 7.6 8.5 13.1 10.6 11.1 11.4 19.2 6.6 6.9 6.9 14.0 6.7 13.3 17.4 6.3 16.8 8.8 5.3 5.6 15.6 11.4 4.1 5.5 11.7 10.5 6.8 14.7 9.1 6.8 5.6 19.5 5.0 10.3 6.9 18.4 12.0 9.4 3.6 8.6 11.9 8.2 11.0 6.7 4.5 10.6 7.5 6.2 11.1 9.9 6.5 8.0 9.5 15.3 18.7 6.8 36.3 5.0 2.0 1.8 7.1 4.3 2.6 5.5 2.4 4.2 3.9 3.3 5.3 3.6 4.1 3.8 3.8 2.0 3.8 5.0 2.3 3.0 4.0 5.3 3.2 2.7 3.3 3.0 2.3 3.0 3.6 SENP2 "AXAM2, DKFZp762A2316, KIAA1331, SMT3IP2" ENSG00000163904 "SUMO1/sentrin/SMT3 specific peptidase 2" Q9HC62 3 185582496-185633551 "Enzymes, Plasma proteins, Predicted intracellular proteins, Transporters" "mRNA transport, Protein transport, Translocation, Transport, Ubl conjugation pathway, Wnt signaling pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA029247, HPA029248" Approved Supported Cytosol Cytosol "HPA029247: AB_10599305, HPA029248: AB_10601855" "unprognostic (4.57e-2)" "unprognostic (1.84e-2)" "unprognostic (6.80e-2)" "prognostic unfavourable (7.98e-5)" "unprognostic (7.85e-2)" "unprognostic (2.90e-2)" "unprognostic (4.41e-3)" "unprognostic (1.45e-1)" "unprognostic (1.59e-1)" "unprognostic (1.46e-1)" "unprognostic (1.85e-1)" "unprognostic (8.41e-3)" "unprognostic (5.12e-2)" "unprognostic (6.92e-2)" "unprognostic (1.60e-1)" "unprognostic (1.92e-1)" "unprognostic (1.56e-1)" 10.3 10.1 16.0 7.6 19.8 13.8 11.6 18.8 20.2 8.7 8.8 13.8 7.8 9.2 9.5 15.4 9.3 9.7 7.0 10.9 15.2 15.1 11.3 14.2 9.5 8.6 14.6 12.0 16.0 9.1 15.6 16.7 13.4 13.9 9.7 9.6 9.1 11.0 10.3 24.6 13.9 8.5 9.2 12.9 9.2 9.4 34.9 17.1 11.0 11.2 7.3 8.9 8.5 9.3 4.2 4.4 7.8 3.2 5.1 3.8 1.9 15.2 3.1 7.6 8.6 13.7 9.3 9.9 7.2 8.1 9.0 9.6 11.6 4.9 8.2 13.5 6.4 8.1 15.8 5.8 13.3 6.1 7.5 5.6 6.4 6.9 7.3 8.2 3.7 5.7 8.7 5.1 6.2 6.2 6.6 11.8 7.7 7.6 6.9 9.1 28.1 5.3 8.2 10.4 13.7 4.9 5.1 7.9 8.8 5.9 13.2 11.0 18.1 11.0 3.9 6.0 6.5 10.9 11.2 13.6 16.2 15.2 9.8 8.8 8.1 7.2 3.0 5.4 3.7 2.8 3.8 3.0 3.1 3.0 2.2 4.2 3.7 3.6 7.8 5.1 3.2 4.4 2.7 1.9 16.0 19.8 18.8 20.2 15.2 15.1 14.6 12.0 13.9 17.1 SENP3 "DKFZP586K0919, DKFZp762A152, SMT3IP1, SSP3, Ulp1" ENSG00000161956 "SUMO1/sentrin/SMT3 specific peptidase 3" Q9H4L4 17 7561875-7571969 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in some" "Low lineage specificity" "Detected in many" HPA060290 Supported Supported Nucleoplasm,Nucleoli "Nucleoplasm, Nucleoli" "HPA060290: " "unprognostic (5.68e-2)" "unprognostic (2.39e-1)" "unprognostic (1.65e-1)" "unprognostic (1.01e-1)" "unprognostic (3.34e-1)" "unprognostic (3.48e-1)" "unprognostic (1.30e-3)" "unprognostic (2.82e-1)" "unprognostic (7.37e-2)" "unprognostic (3.72e-2)" "prognostic favourable (6.22e-5)" "unprognostic (2.71e-2)" "unprognostic (1.96e-1)" "unprognostic (1.42e-1)" "unprognostic (1.37e-1)" "unprognostic (8.21e-2)" "unprognostic (2.56e-2)" 16.3 16.0 22.3 20.9 23.4 16.6 18.0 29.2 38.4 15.9 22.5 18.4 16.8 16.2 18.6 22.7 18.6 19.9 17.0 26.1 21.0 19.2 17.5 15.1 18.7 18.8 20.0 23.3 19.6 17.8 29.5 17.3 23.6 17.2 16.0 20.5 17.3 18.6 21.9 22.0 20.8 17.6 23.1 15.3 18.9 17.2 28.8 16.4 18.9 19.0 14.2 23.4 16.8 32.8 0.8 0.7 1.1 0.7 1.1 1.7 0.3 26.2 31.8 18.9 29.2 21.4 15.7 19.7 19.3 19.8 33.6 31.6 19.0 11.5 31.4 19.1 25.3 25.3 40.6 30.1 28.3 22.1 37.1 16.3 27.0 19.4 29.0 15.0 20.8 20.1 30.8 38.3 37.6 26.9 20.8 8.8 25.9 17.6 36.3 11.4 23.4 19.4 33.3 17.7 18.1 22.4 15.4 18.9 24.4 19.3 18.7 20.5 15.7 9.8 14.1 19.3 16.8 18.3 41.3 13.0 13.5 19.9 19.5 15.9 28.5 0.1 0.7 0.2 0.4 0.4 0.1 0.4 0.2 1.3 0.1 0.8 1.7 0.5 1.1 1.1 0.1 0.7 0.3 0.3 22.3 23.4 29.2 38.4 21.0 19.2 20.0 23.3 17.2 16.4 SENP5 MGC27076 ENSG00000119231 "SUMO1/sentrin specific peptidase 5" Q96HI0 3 196867856-196934714 "Enzymes, Predicted intracellular proteins" "Cell cycle, Cell division, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA006684 Supported "Nucleoli,Plasma membrane" Nucleoli "Plasma membrane" "HPA006684: " "unprognostic (4.07e-2)" "unprognostic (4.91e-3)" "unprognostic (7.63e-2)" "prognostic unfavourable (4.04e-4)" "unprognostic (4.13e-1)" "unprognostic (1.08e-1)" "prognostic unfavourable (4.15e-4)" "unprognostic (2.95e-1)" "unprognostic (2.20e-1)" "unprognostic (2.88e-1)" "unprognostic (2.89e-1)" "unprognostic (9.57e-3)" "prognostic unfavourable (2.14e-5)" "unprognostic (2.02e-1)" "unprognostic (1.62e-1)" "unprognostic (1.62e-2)" "unprognostic (6.71e-2)" 13.8 13.5 20.0 15.3 20.0 25.7 16.1 28.3 23.8 15.0 15.1 16.1 14.5 11.3 14.6 16.2 16.3 12.9 14.4 15.9 18.9 21.7 13.6 19.5 15.2 15.9 19.4 18.4 17.5 15.7 19.8 21.5 17.8 23.5 15.1 14.0 12.0 13.2 15.9 17.8 16.4 13.0 16.8 18.2 17.1 14.0 36.6 16.4 19.3 14.1 9.2 21.1 14.9 20.1 8.9 7.8 15.8 8.7 7.6 8.9 4.2 13.1 6.0 9.6 8.6 8.1 9.8 7.6 8.4 9.0 9.1 14.7 10.4 5.2 12.3 23.4 9.2 9.1 9.9 4.5 14.9 6.6 6.5 16.7 8.9 7.3 9.5 13.7 7.9 8.4 12.1 9.3 9.9 8.9 11.0 19.1 10.6 11.3 12.9 8.1 7.4 11.9 8.3 7.7 8.3 4.5 7.5 6.0 8.0 9.4 10.6 10.3 17.8 10.5 10.0 8.9 9.2 12.2 17.1 20.4 35.7 26.5 12.0 11.1 10.1 15.8 7.6 7.1 8.9 8.1 8.1 8.9 8.6 8.8 5.0 8.5 8.0 8.6 14.9 7.6 8.7 7.8 6.9 4.2 20.0 20.0 28.3 23.8 18.9 21.7 19.4 18.4 23.5 16.4 SENP6 "KIAA0797, SUSP1" ENSG00000112701 "SUMO1/sentrin specific peptidase 6" Q9GZR1 6 75601509-75718278 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA024376 Approved Supported Nucleoplasm,Cytosol Nucleoplasm Cytosol "HPA024376: AB_1856678" "unprognostic (9.86e-2)" "unprognostic (1.20e-2)" "unprognostic (4.84e-2)" "unprognostic (1.87e-2)" "unprognostic (6.38e-3)" "unprognostic (7.33e-2)" "unprognostic (1.13e-2)" "unprognostic (2.97e-1)" "unprognostic (3.93e-2)" "unprognostic (5.32e-3)" "unprognostic (7.81e-2)" "unprognostic (9.24e-2)" "prognostic unfavourable (6.09e-4)" "unprognostic (1.78e-1)" "unprognostic (1.74e-1)" "prognostic unfavourable (2.83e-5)" "unprognostic (1.72e-1)" 25.9 20.0 24.3 21.8 24.5 27.1 25.9 35.0 24.3 32.5 27.7 23.5 24.9 16.8 37.7 21.2 21.0 27.4 21.5 20.0 22.8 19.8 24.1 22.5 22.5 21.1 29.6 20.3 38.7 21.8 40.1 44.2 26.8 27.0 27.7 21.8 23.0 20.4 25.7 27.8 22.0 24.1 43.0 27.2 24.7 21.3 26.1 28.6 28.5 34.8 15.8 23.9 27.1 34.0 9.9 10.9 19.4 13.1 9.8 11.2 5.5 10.7 11.3 25.7 18.4 20.0 26.7 19.1 19.4 21.7 16.4 20.6 15.5 10.4 18.3 18.4 22.4 13.8 24.1 12.9 25.5 26.8 20.8 27.7 13.6 14.4 27.8 24.0 20.4 20.6 21.6 15.4 34.4 27.1 33.4 20.3 20.1 13.1 9.5 13.0 15.6 9.6 18.0 13.6 26.6 17.6 16.1 22.5 23.2 16.6 14.7 16.8 13.2 23.0 22.6 14.7 16.1 7.5 20.0 23.3 23.1 14.6 7.4 23.0 15.5 5.2 7.4 19.4 7.7 7.9 11.2 9.3 7.8 10.2 8.7 9.9 11.2 9.9 14.7 9.8 13.1 10.9 6.5 5.5 24.3 24.5 35.0 24.3 22.8 19.8 29.6 20.3 27.0 28.6 SENP7 ENSG00000138468 "SUMO1/sentrin specific peptidase 7" Q9BQF6 3 101324205-101513241 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA027259 Approved Approved Nucleoplasm,Cytosol "Nucleoplasm, Cytosol" "HPA027259: AB_1856679" "unprognostic (1.50e-1)" "unprognostic (6.12e-2)" "unprognostic (2.78e-2)" "unprognostic (7.31e-2)" "unprognostic (2.44e-2)" "prognostic favourable (4.23e-4)" "unprognostic (1.38e-3)" "unprognostic (9.25e-3)" "unprognostic (8.80e-2)" "unprognostic (2.24e-1)" "unprognostic (7.77e-3)" "unprognostic (1.94e-1)" "unprognostic (9.85e-2)" "unprognostic (8.08e-3)" "unprognostic (3.27e-1)" "unprognostic (9.03e-2)" "unprognostic (2.23e-2)" 17.0 9.0 11.0 19.1 14.5 19.5 16.5 35.5 19.5 21.7 13.1 11.8 8.2 6.4 24.3 15.2 11.9 18.6 12.8 10.0 13.2 9.1 10.5 7.7 11.5 19.0 12.9 10.8 27.9 15.9 22.4 24.4 17.0 18.7 15.1 10.0 9.2 10.2 11.1 11.1 18.6 13.8 16.0 17.3 14.1 13.6 7.9 16.8 32.1 16.0 9.4 15.4 17.2 14.0 6.8 3.2 24.5 4.1 6.2 7.6 3.8 6.9 4.7 23.4 12.9 4.5 6.9 4.3 4.1 3.0 6.8 8.4 3.1 6.5 5.4 6.3 3.9 7.1 7.3 3.7 13.7 10.0 2.1 9.8 3.7 4.2 3.7 5.6 9.6 5.2 6.8 3.4 7.8 9.7 8.0 13.9 6.4 4.6 10.3 6.6 4.8 5.1 11.6 6.2 4.9 8.1 4.1 9.1 7.0 3.8 3.8 5.1 6.3 7.6 7.9 9.5 5.8 3.1 4.0 9.9 5.9 12.7 3.3 7.5 7.7 24.5 4.1 3.8 4.2 3.6 5.2 4.2 5.6 4.2 3.2 6.8 7.6 5.1 12.6 6.2 3.8 2.8 4.5 3.8 11.0 14.5 35.5 19.5 13.2 9.1 12.9 10.8 18.7 16.8 SENP8 "DEN1, HsT17512, NEDP1, PRSC2" ENSG00000166192 "SUMO/sentrin peptidase family member, NEDD8 specific" Q96LD8 15 72114258-72143688 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "testis: 26.5" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA036273 Approved Approved Nucleoplasm,Vesicles "Nucleoplasm, Vesicles" "HPA036273: AB_10669985" "unprognostic (1.83e-2)" "unprognostic (1.78e-1)" "unprognostic (9.85e-4)" "unprognostic (5.43e-2)" "unprognostic (1.49e-1)" "unprognostic (6.09e-3)" "unprognostic (3.06e-2)" "unprognostic (4.35e-2)" "unprognostic (1.06e-1)" "unprognostic (2.04e-1)" "unprognostic (3.11e-2)" "unprognostic (1.19e-1)" "unprognostic (8.46e-12)" "unprognostic (1.24e-1)" "unprognostic (1.12e-1)" "unprognostic (1.85e-2)" "unprognostic (1.54e-2)" 2.5 4.8 6.4 3.4 8.1 5.0 4.4 5.7 8.0 4.0 4.0 3.9 6.4 3.8 3.9 6.7 4.8 5.1 4.2 7.7 7.3 6.9 9.3 5.0 3.3 3.1 6.2 7.7 5.3 6.2 3.9 12.7 3.7 8.0 5.9 4.3 4.2 5.6 6.6 11.0 3.5 3.3 4.2 5.0 3.1 4.3 26.5 4.3 2.2 12.0 4.5 2.7 4.9 3.0 3.0 5.7 2.1 5.6 7.1 3.7 2.1 1.9 3.2 6.3 5.0 7.6 9.2 3.5 5.0 3.1 3.0 2.8 2.7 4.5 1.9 7.4 3.2 4.5 9.6 7.7 4.4 2.1 5.3 3.0 4.5 2.2 5.3 3.6 1.7 4.5 7.8 1.9 8.4 2.8 4.6 3.6 7.1 4.9 3.6 4.7 5.0 3.3 2.4 5.4 4.0 7.9 3.4 7.7 2.5 5.3 4.4 5.2 6.7 2.7 2.9 6.1 2.2 10.1 2.5 3.0 3.6 2.3 2.9 5.0 4.3 2.1 1.9 1.4 1.6 3.9 2.3 3.0 2.8 2.5 5.7 1.4 3.1 3.7 0.7 7.1 5.6 1.7 2.1 2.1 6.4 8.1 5.7 8.0 7.3 6.9 6.2 7.7 8.0 4.3 SPG7 "CAR, CMAR, SPG5C" ENSG00000197912 "SPG7, paraplegin matrix AAA peptidase subunit" Q9UQ90 16 89490719-89557768 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Metalloprotease, Protease" "Disease mutation, Hereditary spastic paraplegia, Neurodegeneration, Osteogenesis imperfecta" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "unprognostic (1.42e-1)" "unprognostic (1.72e-1)" "unprognostic (4.12e-2)" "prognostic favourable (2.22e-4)" "unprognostic (4.10e-1)" "unprognostic (1.11e-2)" "unprognostic (1.14e-1)" "unprognostic (1.50e-1)" "unprognostic (1.54e-1)" "unprognostic (2.33e-1)" "prognostic favourable (4.91e-4)" "unprognostic (3.56e-2)" "unprognostic (7.01e-2)" "unprognostic (1.44e-2)" "unprognostic (2.58e-1)" "unprognostic (1.71e-1)" "prognostic favourable (4.25e-4)" 14.6 23.6 15.6 11.7 19.9 14.5 17.5 25.2 33.2 14.2 14.9 19.1 19.5 18.0 18.3 16.1 14.2 13.9 15.9 34.3 15.6 15.6 22.3 24.5 14.1 16.2 13.9 23.7 21.6 22.1 17.9 21.0 10.2 19.3 15.9 14.0 16.5 17.4 18.1 75.6 27.9 17.7 17.8 16.9 17.8 16.5 24.1 12.9 13.3 28.4 18.4 16.1 16.6 13.4 6.6 5.0 7.9 4.9 7.2 6.4 2.0 5.4 14.9 7.7 13.8 14.8 9.1 6.1 14.6 10.2 8.5 5.1 11.8 11.4 8.6 15.7 9.0 14.6 10.5 10.9 9.3 4.9 13.2 4.1 7.4 21.3 6.5 3.4 5.5 5.1 7.6 5.3 6.2 11.9 9.4 3.7 8.1 10.7 7.4 12.6 13.7 10.8 13.8 13.6 5.2 8.2 8.4 8.3 5.5 21.4 3.7 4.4 12.1 8.9 18.5 6.7 9.4 4.7 6.8 6.1 9.6 7.4 8.7 9.9 8.0 7.9 4.9 7.4 5.6 4.7 5.4 3.3 3.5 2.8 5.0 6.6 6.4 4.3 7.2 7.2 3.3 4.9 3.6 2.0 15.6 19.9 25.2 33.2 15.6 15.6 13.9 23.7 19.3 12.9 SPPL2A "IMP3, PSL2" ENSG00000138600 "Signal peptide peptidase like 2A" Q8TCT8 15 50702266-50765808 "Enzymes, Plasma proteins, Predicted membrane proteins, Transporters" "Hydrolase, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA036062, HPA067304" Enhanced Supported Vesicles Vesicles "HPA036062: AB_10611670, HPA067304: " "unprognostic (1.66e-1)" "unprognostic (1.03e-1)" "unprognostic (2.70e-1)" "unprognostic (5.82e-3)" "unprognostic (3.71e-1)" "unprognostic (1.70e-1)" "unprognostic (2.15e-1)" "unprognostic (1.88e-1)" "unprognostic (2.22e-2)" "unprognostic (6.36e-2)" "unprognostic (2.04e-2)" "unprognostic (4.00e-2)" "unprognostic (3.11e-2)" "unprognostic (2.26e-2)" "unprognostic (1.44e-2)" "unprognostic (6.96e-2)" "unprognostic (3.66e-1)" 20.5 23.5 6.9 18.0 8.6 15.0 23.3 6.2 8.1 16.4 29.3 10.8 15.3 24.9 14.5 17.9 18.7 13.0 14.9 37.6 7.8 5.3 23.3 44.8 19.2 23.9 8.3 6.1 13.2 32.7 61.0 11.8 32.2 14.4 14.7 26.9 14.9 21.7 15.5 63.1 15.8 39.2 20.5 8.5 21.2 18.3 10.2 7.4 21.6 15.6 17.4 17.7 19.7 13.9 9.8 19.4 24.0 27.3 11.9 15.4 22.4 15.2 26.5 10.3 13.7 40.9 24.4 16.3 24.6 41.3 22.6 32.3 30.7 17.7 9.5 18.4 48.1 23.0 12.4 14.9 25.3 19.4 7.6 18.0 18.2 15.9 33.8 11.1 29.4 21.2 27.5 18.7 30.3 22.2 13.5 37.4 29.8 35.2 5.2 4.3 4.5 6.0 6.5 16.1 20.8 31.1 35.5 8.3 9.4 14.8 28.6 16.6 20.3 22.1 27.0 36.6 14.7 23.4 28.9 15.2 26.0 10.5 16.5 18.8 24.9 21.2 26.9 24.0 15.4 24.6 9.7 9.8 12.6 13.9 19.4 9.3 7.2 11.5 19.4 11.9 27.3 17.1 15.4 22.4 6.9 8.6 6.2 8.1 7.8 5.3 8.3 6.1 14.4 7.4 SPPL2B "IMP4, KIAA1532, PSL1" ENSG00000005206 "Signal peptide peptidase like 2B" Q8TCT7 19 2328615-2354806 "Enzymes, Predicted membrane proteins" "Hydrolase, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB005592, HPA039292" Approved Approved "Nucleoplasm,Plasma membrane,Centrosome" "Nucleoplasm, Plasma membrane" Centrosome "CAB005592: AB_325074, HPA039292: " "unprognostic (4.16e-2)" "unprognostic (2.97e-2)" "unprognostic (2.48e-2)" "prognostic favourable (5.00e-5)" "unprognostic (2.34e-1)" "unprognostic (1.54e-3)" "unprognostic (1.74e-1)" "unprognostic (7.93e-3)" "unprognostic (3.00e-1)" "unprognostic (1.72e-1)" "prognostic favourable (1.33e-4)" "unprognostic (3.29e-3)" "prognostic unfavourable (6.45e-4)" "unprognostic (2.26e-2)" "unprognostic (2.45e-1)" "unprognostic (3.02e-1)" "unprognostic (3.40e-2)" 5.4 4.6 5.0 11.7 5.4 11.7 4.0 6.9 6.9 3.4 9.0 7.9 9.6 19.3 4.7 10.0 3.2 5.2 9.8 3.3 5.6 4.2 3.9 3.5 10.3 7.1 4.7 3.4 13.8 6.3 11.0 6.8 7.1 4.7 3.9 6.0 10.5 8.7 7.5 8.7 16.2 5.0 7.0 8.1 13.8 20.1 6.4 9.3 3.0 3.7 5.7 2.3 2.0 14.4 17.4 9.3 7.7 6.2 8.2 5.9 8.3 13.3 5.7 10.2 4.7 4.8 14.7 10.9 3.2 4.0 4.3 9.3 9.5 8.0 10.3 5.1 11.2 1.9 3.7 1.2 9.3 8.3 5.3 20.9 12.5 8.9 9.3 6.9 7.0 4.3 3.8 2.7 5.6 8.5 20.4 2.4 9.2 10.0 11.8 10.7 5.5 16.8 3.0 21.9 4.3 21.0 10.2 9.7 10.9 6.7 8.4 11.1 15.6 12.4 7.3 5.3 18.5 8.5 26.9 9.6 8.3 9.2 10.9 12.7 9.3 7.7 7.0 6.6 7.5 4.8 9.0 6.0 6.5 9.4 14.4 7.8 8.2 3.4 6.2 5.1 17.4 5.9 5.9 SPPL2C IMP5 ENSG00000185294 "Signal peptide peptidase like 2C" Q8IUH8 17 45844835-45847072 "Enzymes, Predicted membrane proteins" "Hydrolase, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 31 "testis: 45.0" "Not detected" "Not detected" "Not detected" "Not detected" "Region enriched" "Detected in single" 9 "cerebellum: 1.4" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in many" "unprognostic (6.70e-4)" "unprognostic (1.34e-1)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.4 0.2 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 45.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.4 0.1 0.0 0.0 0.0 0.0 0.0 0.0 SPPL3 "DKFZP586C1324, IMP2, MGC126674, MGC126676, MGC90402, PSL4" ENSG00000157837 "Signal peptide peptidase like 3" Q8TCT6 12 120762510-120904371 "Enzymes, Predicted membrane proteins" "Hydrolase, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA004194, HPA059958" Uncertain Supported "Vesicles,Plasma membrane" "Vesicles, Plasma membrane" "HPA004194: , HPA059958: " "unprognostic (3.29e-1)" "unprognostic (2.29e-2)" "unprognostic (3.39e-2)" "unprognostic (1.63e-1)" "unprognostic (2.06e-1)" "unprognostic (7.96e-3)" "prognostic unfavourable (1.29e-5)" "unprognostic (3.17e-2)" "unprognostic (1.10e-1)" "unprognostic (1.28e-1)" "unprognostic (2.48e-1)" "unprognostic (2.44e-1)" "unprognostic (2.66e-1)" "unprognostic (9.34e-2)" "unprognostic (9.92e-2)" "unprognostic (7.54e-2)" "unprognostic (9.40e-2)" 17.8 15.3 18.9 12.8 23.1 13.9 19.4 21.8 31.4 25.2 20.4 25.6 18.4 14.0 23.1 13.3 39.5 23.3 18.2 13.9 17.4 18.3 18.3 14.9 20.8 21.5 19.2 20.6 25.9 19.6 42.4 14.3 21.9 16.5 16.9 21.7 19.1 19.2 22.7 13.8 48.3 18.5 23.5 17.1 19.0 14.2 34.7 20.8 25.2 24.7 22.2 20.6 19.8 29.3 4.1 6.3 7.3 2.9 2.8 4.4 1.5 12.3 12.3 18.7 11.7 24.8 16.8 13.2 9.5 28.4 20.5 16.5 12.8 12.7 11.4 0.1 16.5 15.2 19.1 20.5 21.3 9.0 11.7 9.8 7.4 9.7 26.2 11.2 12.7 16.8 32.9 17.6 16.5 20.1 10.7 5.7 17.6 10.9 14.9 9.0 12.5 8.8 8.9 15.8 8.1 16.1 35.2 12.8 13.8 18.1 8.4 14.3 25.2 7.8 14.9 9.5 13.0 5.8 7.1 13.4 24.0 11.1 14.2 9.4 15.7 7.3 2.9 2.6 3.2 2.8 4.4 3.2 4.0 4.0 4.9 4.1 3.9 4.3 5.5 2.8 2.4 6.3 3.1 1.5 18.9 23.1 21.8 31.4 17.4 18.3 19.2 20.6 16.5 20.8 ST14 "HAI, MT-SP1, PRSS14, SNC19, TMPRSS14" ENSG00000149418 "Suppression of tumorigenicity 14" Q9Y5Y6 11 130159562-130210376 "Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted membrane proteins" "Hydrolase, Protease, Serine protease" "Cancer-related genes, Disease mutation, Hypotrichosis, Ichthyosis" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 94.1" "Cell line enhanced" "Detected in some" "CACO-2: 35.7;CAPAN-2: 72.1;HaCaT: 50.5;RPMI-8226: 47.3;SK-BR-3: 33.4;T-47d: 50.5;U-698: 34.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Cell type enriched" "Detected in many" 4 "plasmacytoid DC: 18.2" "Lineage enriched" "Detected in many" 5 "dendritic cells: 18.2" "Not detected" "Not detected" "Low region specificity" "Detected in many" HPA047014 Approved Nucleoplasm,Vesicles 220000 "Nucleoplasm, Vesicles" "HPA047014: " "unprognostic (1.17e-1)" "unprognostic (1.15e-1)" "unprognostic (9.62e-2)" "unprognostic (1.32e-1)" "unprognostic (2.17e-2)" "unprognostic (7.94e-2)" "unprognostic (1.20e-1)" "unprognostic (3.97e-2)" "unprognostic (5.29e-1)" "unprognostic (3.21e-1)" "unprognostic (1.03e-3)" "unprognostic (2.25e-1)" "prognostic favourable (5.03e-11)" "unprognostic (1.92e-2)" "unprognostic (2.71e-1)" "unprognostic (1.28e-2)" "unprognostic (5.60e-2)" 10.1 1.8 0.7 21.9 1.8 0.5 5.5 0.8 1.4 8.9 48.6 0.5 23.8 33.8 2.8 16.9 38.9 9.7 32.4 1.1 0.5 0.5 30.5 3.2 9.5 7.5 1.8 0.6 3.6 34.3 8.4 9.5 12.7 1.5 12.1 15.4 0.7 25.1 15.8 0.7 17.8 94.1 1.2 1.8 4.0 16.7 2.1 1.5 5.2 24.0 20.1 28.4 8.3 14.9 3.8 18.2 2.3 2.7 0.0 0.1 0.8 26.2 0.0 0.0 0.1 0.0 0.0 14.3 0.0 0.0 0.0 0.0 35.7 72.1 26.0 2.7 0.0 50.5 0.0 16.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 3.4 0.1 0.0 8.1 0.0 0.0 0.0 0.0 0.0 0.0 20.3 0.0 0.1 0.2 0.1 0.0 0.0 47.3 4.7 21.5 2.9 0.0 0.2 33.4 0.0 50.5 5.1 0.0 0.0 0.4 0.1 0.1 0.0 0.0 34.4 0.0 8.0 0.0 0.0 2.7 2.3 0.0 1.5 0.1 3.8 0.0 0.0 4.5 2.3 0.0 0.0 0.3 0.0 0.2 18.2 0.0 0.8 0.7 1.8 0.8 1.4 0.5 0.5 1.8 0.6 1.5 1.5 STAMBP AMSH ENSG00000124356 "STAM binding protein" O95630 2 73828916-73873659 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Metalloprotease, Protease" "Disease mutation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell line enriched" "Detected in all" 12 "LHCN-M2: 158.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA035800, HPA035801" Uncertain Enhanced "Nucleoplasm,Plasma membrane,Cytosol" 11000 Nucleoplasm "Plasma membrane, Cytosol" "HPA035800: AB_10670591, HPA035801: " "unprognostic (1.86e-2)" "unprognostic (1.14e-1)" "unprognostic (2.16e-1)" "prognostic unfavourable (4.70e-5)" "unprognostic (6.13e-2)" "unprognostic (2.08e-3)" "unprognostic (3.73e-2)" "unprognostic (1.71e-1)" "unprognostic (6.58e-2)" "unprognostic (2.96e-2)" "prognostic unfavourable (5.79e-4)" "unprognostic (1.01e-1)" "unprognostic (2.29e-1)" "unprognostic (7.72e-2)" "unprognostic (2.63e-1)" "unprognostic (1.43e-1)" "unprognostic (2.89e-1)" 12.9 12.8 22.1 13.9 23.0 10.5 17.8 20.1 21.8 18.1 18.4 35.0 13.6 17.8 23.1 15.4 22.7 16.5 14.7 19.0 23.3 21.2 19.6 16.9 13.4 15.3 33.0 14.3 16.3 15.1 20.9 17.8 20.6 26.3 20.2 20.7 14.6 18.3 15.7 30.1 14.4 25.2 19.0 54.7 13.8 15.6 13.3 22.3 18.4 20.1 15.9 19.0 16.8 16.4 17.6 16.9 27.8 17.8 16.7 20.7 12.3 5.3 6.2 4.9 4.5 4.6 5.5 5.6 3.3 4.5 6.0 5.8 10.3 5.1 4.4 5.2 2.7 4.2 5.2 11.5 6.9 7.8 5.9 6.0 4.3 8.0 6.4 4.9 7.2 4.4 8.3 7.1 10.3 3.5 6.5 6.8 158.8 6.5 7.6 4.4 7.8 3.3 5.3 12.9 6.3 6.5 6.0 9.0 6.6 4.0 4.9 6.9 4.6 2.9 3.1 5.4 6.5 3.3 5.8 6.5 6.2 3.4 6.7 5.3 6.3 22.6 16.2 27.8 14.4 17.8 15.4 17.6 16.7 14.0 16.9 16.2 17.5 13.2 24.1 16.7 15.7 16.4 20.7 12.3 22.1 23.0 20.1 21.2 23.3 21.2 33.0 14.3 26.3 22.3 STAMBPL1 "ALMalpha, AMSH-FP, AMSH-LP, bA399O19.2, FLJ31524, KIAA1373" ENSG00000138134 "STAM binding protein like 1" Q96FJ0 10 88879734-88975153 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "testis: 18.6" "Low cell line specificity" "Detected in many" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" HPA040202 Uncertain Approved "Plasma membrane" "Plasma membrane" "HPA040202: AB_10805708" "unprognostic (2.73e-1)" "unprognostic (1.95e-1)" "unprognostic (7.56e-2)" "unprognostic (4.25e-2)" "unprognostic (6.46e-2)" "unprognostic (6.27e-2)" "unprognostic (1.68e-2)" "unprognostic (1.05e-2)" "unprognostic (4.67e-2)" "unprognostic (8.20e-2)" "unprognostic (2.78e-1)" "unprognostic (6.57e-2)" "prognostic unfavourable (1.08e-5)" "unprognostic (4.41e-2)" "unprognostic (4.06e-2)" "unprognostic (1.50e-1)" "unprognostic (4.40e-3)" 3.9 15.9 3.7 6.8 5.1 2.8 2.1 12.4 8.9 2.0 5.8 3.4 1.5 4.5 2.7 1.5 2.7 1.2 2.9 4.8 3.3 3.4 1.5 1.7 2.9 11.3 2.6 14.8 8.5 1.8 2.2 6.6 1.5 4.1 1.9 8.0 1.5 1.5 1.5 1.5 3.4 6.1 1.8 3.1 6.0 3.1 18.6 3.2 1.5 1.5 1.5 9.5 3.9 2.7 10.5 15.2 4.3 0.6 13.1 14.7 4.5 6.7 8.0 0.5 0.3 8.0 15.3 0.0 14.2 14.0 9.1 8.2 0.3 12.9 8.2 1.0 7.7 3.3 2.0 2.9 9.3 7.3 5.0 2.1 5.7 0.4 5.4 9.0 2.9 5.5 0.7 15.3 4.9 0.2 0.0 3.7 24.5 1.4 15.1 10.8 3.0 6.2 1.5 6.0 1.8 3.5 2.6 4.6 5.5 1.8 0.6 16.1 1.0 1.9 2.0 8.1 5.9 9.8 8.8 8.7 8.2 7.6 8.9 9.2 7.7 4.3 0.6 4.2 6.3 0.6 8.2 10.5 9.2 7.9 0.9 7.0 9.9 5.9 0.9 13.1 0.3 15.2 14.7 4.5 3.7 5.1 12.4 8.9 3.3 3.4 2.6 14.8 4.1 3.2 SUPT16H "CDC68, FACT, FACTP140, FLJ10857, FLJ14010, SPT16/CDC68" ENSG00000092201 "SPT16 homolog, facilitates chromatin remodeling subunit" Q9Y5B9 14 21351472-21384266 "Enzymes, Plasma proteins, Predicted intracellular proteins" "DNA damage, DNA repair, DNA replication, Host-virus interaction, Transcription, Transcription regulation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB022551, HPA049787" Enhanced Supported "Nucleoplasm,Nucleoli fibrillar center" Nucleoplasm "Nucleoli fibrillar center" "CAB022551: , HPA049787: " "unprognostic (1.65e-1)" "unprognostic (2.22e-1)" "unprognostic (3.52e-2)" "unprognostic (7.12e-2)" "unprognostic (7.32e-2)" "unprognostic (1.22e-2)" "unprognostic (1.38e-3)" "unprognostic (1.86e-1)" "unprognostic (7.65e-2)" "unprognostic (4.91e-2)" "unprognostic (1.09e-1)" "unprognostic (1.26e-1)" "unprognostic (6.48e-3)" "unprognostic (1.02e-1)" "unprognostic (7.58e-3)" "unprognostic (9.05e-2)" "unprognostic (5.87e-3)" 21.6 18.3 16.3 21.6 26.2 21.5 21.3 39.1 27.9 22.8 21.3 14.4 20.7 13.5 31.5 18.5 20.9 23.7 14.5 15.9 17.9 16.2 17.7 14.1 17.1 28.0 18.8 22.8 29.0 15.7 40.3 24.0 18.9 28.6 18.8 21.5 11.3 19.3 20.5 21.4 22.1 19.9 27.4 18.9 22.6 19.1 24.9 19.0 32.7 20.3 17.0 29.5 24.6 20.7 23.3 17.1 21.1 20.4 23.2 26.8 16.7 29.9 28.3 39.3 28.8 17.8 17.8 28.0 27.1 21.7 33.2 31.3 27.4 27.1 63.7 10.4 19.7 32.1 49.7 24.5 50.3 20.2 21.2 38.6 25.9 38.4 18.2 54.5 28.8 15.6 15.1 27.6 31.3 22.4 31.7 27.4 27.4 19.4 50.9 16.6 43.8 28.1 55.1 44.9 34.4 13.3 33.2 39.4 33.6 43.9 26.4 16.5 14.6 25.9 18.9 29.1 24.3 18.0 29.3 27.4 45.7 64.2 10.7 32.2 22.0 21.1 13.1 19.6 22.8 17.3 26.8 23.3 21.8 25.3 17.1 21.3 25.0 25.1 11.0 23.2 20.4 16.1 20.3 16.7 16.3 26.2 39.1 27.9 17.9 16.2 18.8 22.8 28.6 19.0 TFR2 "HFE3, TFRC2" ENSG00000106327 "Transferrin receptor 2" Q9UP52 7 100620416-100642779 "Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted membrane proteins, Transporters" Receptor "Disease mutation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 20 "liver: 112.6" "Group enriched" "Detected in some" 11 "HEL: 27.8;HMC-1: 38.6;K-562: 25.7" "Cancer enriched" "Detected in many" 70 "liver cancer: 136.2" "Not detected" "Not detected" "Group enriched" "Detected in some" 46 "basophil: 5.5;eosinophil: 3.9" "Lineage enriched" "Detected in single" 54 "granulocytes: 5.5" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "HPA011937, CAB016255" Enhanced "CAB016255: AB_628395, HPA011937: AB_1858243" "unprognostic (4.18e-2)" "unprognostic (1.97e-2)" "unprognostic (2.74e-1)" "unprognostic (1.04e-1)" "unprognostic (1.26e-2)" "unprognostic (4.13e-2)" "prognostic favourable (2.48e-4)" "unprognostic (2.29e-2)" "unprognostic (4.49e-2)" "unprognostic (9.26e-2)" "unprognostic (1.93e-1)" "unprognostic (2.90e-1)" "unprognostic (1.18e-9)" "unprognostic (6.51e-2)" "unprognostic (1.68e-1)" "unprognostic (3.28e-1)" "unprognostic (8.18e-2)" 0.1 0.0 0.1 0.1 0.1 5.3 0.1 0.8 0.1 0.1 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.0 0.3 0.3 0.1 0.0 0.1 112.6 0.1 0.1 0.1 0.1 0.1 0.1 0.0 0.1 0.2 0.1 0.1 0.0 0.1 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.2 1.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.0 5.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 27.8 0.0 2.8 0.0 0.6 38.6 0.0 0.0 0.0 0.0 0.0 25.7 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.5 0.0 3.9 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.8 0.1 0.1 0.0 0.1 0.1 0.1 0.1 TFRC "CD71, p90, TFR1" ENSG00000072274 "Transferrin receptor" P02786 3 196027183-196082189 "Cancer-related genes, CD markers, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, Transporters" "Endocytosis, Host-virus interaction" "Host cell receptor for virus entry, Receptor" "Cancer-related genes, Disease mutation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "placenta: 110.0" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB000153, HPA028598" Enhanced Supported Endosomes,Lysosomes "Secreted to blood" 1310000000 14000000 "Endosomes, Lysosomes" "CAB000153: AB_2533029, HPA028598: AB_10601599" "unprognostic (2.95e-2)" "prognostic unfavourable (3.67e-4)" "unprognostic (2.55e-1)" "unprognostic (1.48e-2)" "unprognostic (6.75e-2)" "unprognostic (7.88e-3)" "prognostic unfavourable (1.15e-4)" "unprognostic (6.92e-2)" "unprognostic (3.30e-3)" "unprognostic (4.35e-2)" "unprognostic (1.34e-2)" "unprognostic (1.14e-2)" "unprognostic (3.63e-3)" "unprognostic (3.65e-2)" "unprognostic (1.19e-2)" "prognostic unfavourable (2.96e-4)" "unprognostic (2.62e-2)" 24.3 11.9 11.9 20.6 11.3 73.8 7.6 9.6 17.8 11.8 25.0 9.5 3.8 11.9 12.1 7.5 18.5 11.7 11.4 18.7 9.5 8.3 15.3 13.6 28.1 8.1 7.4 9.5 50.0 7.8 18.0 6.9 110.0 26.5 7.2 19.4 8.5 8.3 5.0 25.6 9.9 37.4 10.9 13.2 7.9 10.0 8.3 6.1 14.3 7.0 10.5 12.9 11.2 8.0 5.7 7.5 2.2 12.4 1.8 6.5 2.1 21.9 20.0 9.2 18.6 20.4 11.8 57.5 31.4 23.9 22.1 36.7 48.7 20.2 22.5 59.6 11.6 33.9 31.5 10.4 27.1 107.6 10.7 85.3 17.0 22.6 16.1 69.9 17.3 13.3 10.3 19.0 17.2 7.3 35.5 21.6 17.2 20.3 22.9 14.8 28.0 41.0 12.2 13.7 27.0 19.8 55.6 21.0 8.7 30.3 79.7 7.1 77.4 14.6 9.4 26.3 21.4 23.0 47.0 6.1 47.5 35.2 30.8 19.0 15.9 0.0 1.6 2.2 2.5 7.9 1.7 5.7 2.7 1.7 3.7 3.2 2.5 1.9 0.3 1.8 12.4 7.5 6.5 2.1 11.9 11.3 9.6 17.8 9.5 8.3 7.4 9.5 26.5 6.1 THOP1 ENSG00000172009 "Thimet oligopeptidase 1" P52888 19 2785460-2815807 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB025497, HPA035262" Uncertain Supported Cytosol 1400000 Cytosol "CAB025497: , HPA035262: " "unprognostic (1.52e-2)" "unprognostic (1.73e-3)" "unprognostic (7.94e-2)" "prognostic favourable (2.35e-4)" "unprognostic (1.82e-1)" "unprognostic (2.16e-2)" "unprognostic (9.35e-2)" "unprognostic (1.19e-1)" "unprognostic (4.05e-2)" "unprognostic (1.43e-1)" "unprognostic (1.20e-3)" "unprognostic (3.00e-2)" "unprognostic (1.39e-1)" "prognostic favourable (5.90e-4)" "unprognostic (1.27e-1)" "unprognostic (2.64e-1)" "unprognostic (5.37e-2)" 8.2 9.4 19.1 12.3 19.8 18.4 6.2 21.7 26.1 5.2 11.8 14.1 5.8 24.6 7.5 8.4 11.0 8.4 6.7 11.6 18.5 15.4 7.1 30.4 6.2 11.9 14.1 15.2 11.1 7.8 7.0 12.7 22.3 13.1 18.1 8.2 11.9 13.7 6.8 29.1 11.9 20.0 7.1 10.7 9.8 7.8 27.3 10.9 17.0 7.5 11.5 11.3 5.8 6.8 7.5 9.8 8.0 7.5 3.9 9.5 3.2 29.2 21.8 8.5 18.2 4.4 4.3 30.4 18.3 6.8 18.2 14.8 25.6 9.4 26.4 9.0 7.1 23.8 12.6 15.0 7.7 0.1 26.5 9.3 24.0 30.2 4.7 18.0 14.6 4.8 5.4 15.1 6.8 10.3 21.7 12.9 7.7 22.7 20.0 33.8 25.1 30.1 16.7 11.3 25.0 7.6 17.0 23.1 18.5 16.0 14.4 8.9 14.0 17.5 11.7 14.0 12.1 29.8 30.9 22.7 19.0 17.8 15.6 30.3 16.6 8.0 3.5 1.6 5.5 3.9 4.5 5.6 4.0 7.4 4.9 7.5 5.1 4.3 1.7 3.9 7.5 9.8 9.5 3.2 19.1 19.8 21.7 26.1 18.5 15.4 14.1 15.2 13.1 10.9 TINAG ENSG00000137251 "Tubulointerstitial nephritis antigen" Q9UJW2 6 54307859-54390152 "Enzymes, Predicted intracellular proteins, Predicted secreted proteins" "Cell adhesion" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 11 "intestine: 27.2;kidney: 53.0" "Cell line enriched" "Detected in some" 34 "RPTEC TERT1: 45.1" "Cancer enhanced" "Detected in some" "renal cancer: 15.8" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in all" "HPA035427, HPA073753" Approved "Secreted to extracellular matrix" 26000 "HPA035427: AB_10601822, HPA073753: " "unprognostic (7.62e-3)" "unprognostic (1.12e-2)" "prognostic unfavourable (2.05e-5)" "unprognostic (7.27e-2)" "unprognostic (5.99e-3)" "prognostic favourable (8.75e-5)" "unprognostic (7.10e-2)" 0.0 0.0 0.1 3.6 0.0 0.0 0.0 0.0 0.2 0.0 9.5 0.0 0.0 5.1 0.0 0.0 0.0 0.0 1.7 0.1 0.0 0.1 53.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 6.2 0.0 0.0 0.0 0.2 0.0 27.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 1.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 45.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.2 0.0 0.1 0.2 0.0 0.4 0.0 TINAGL1 "ARG1, LCN7, LIECG3, P3ECSL, TINAGRP" ENSG00000142910 "Tubulointerstitial nephritis antigen like 1" Q9GZM7 1 31576485-31587686 "Enzymes, Predicted intracellular proteins, Predicted secreted proteins" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "placenta: 128.4" "Cell line enhanced" "Detected in many" "BEWO: 57.5;CAPAN-2: 31.4;EFO-21: 72.5;HaCaT: 31.5;HBEC3-KT: 37.1;HUVEC TERT2: 30.7;TIME: 65.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Cell type enhanced" "Detected in some" "basophil: 4.8" "Low lineage specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in some" HPA048695 Approved "Secreted to extracellular matrix" 170000 "HPA048695: " "unprognostic (1.27e-1)" "unprognostic (2.94e-2)" "unprognostic (7.53e-2)" "unprognostic (1.80e-3)" "unprognostic (2.74e-1)" "unprognostic (1.72e-3)" "unprognostic (8.29e-3)" "unprognostic (6.02e-3)" "unprognostic (4.18e-1)" "unprognostic (6.96e-2)" "unprognostic (7.02e-3)" "unprognostic (1.22e-1)" "prognostic favourable (3.65e-6)" "unprognostic (7.42e-2)" "unprognostic (6.64e-2)" "prognostic favourable (9.64e-4)" "unprognostic (3.43e-2)" 43.0 8.4 2.2 11.6 3.4 0.8 60.0 0.8 4.4 30.2 22.0 2.9 14.2 12.0 25.7 23.4 23.7 17.0 36.1 52.6 3.4 2.3 53.3 14.7 24.4 12.8 3.9 3.3 15.5 7.4 3.2 5.6 128.4 5.0 19.4 7.9 12.0 24.2 20.0 19.6 7.6 15.9 22.5 2.7 34.3 16.3 10.3 2.1 0.8 30.7 11.0 6.4 39.8 20.0 1.1 0.6 4.8 0.5 1.5 0.8 0.0 16.4 0.0 0.0 0.1 0.1 0.0 57.5 2.6 0.3 0.1 0.0 7.7 31.4 0.0 72.5 2.3 31.5 0.0 37.1 0.0 0.1 0.0 0.0 1.3 1.9 0.8 0.0 0.1 0.0 6.7 0.0 1.3 30.7 0.4 0.0 0.0 0.0 0.1 0.1 0.1 1.0 0.0 0.0 0.0 10.0 12.7 0.0 0.1 6.6 22.2 0.7 1.3 0.0 65.6 0.0 16.6 0.1 0.4 0.0 0.0 0.2 0.0 0.0 0.5 4.8 0.5 0.5 0.8 0.3 0.5 0.4 0.6 0.5 0.1 1.1 0.8 0.8 2.7 1.5 0.5 0.6 0.5 0.0 2.2 3.4 0.8 4.4 3.4 2.3 3.9 3.3 5.0 2.1 TLL1 ENSG00000038295 "Tolloid like 1" O43897 4 165873258-166103895 "Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins" Differentiation "Developmental protein, Hydrolase, Metalloprotease, Protease" "Atrial septal defect, Disease mutation" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 40.6" "Group enriched" "Detected in some" 4 "HeLa: 8.5;Karpas-707: 13.3;PC-3: 4.8" "Low cancer specificity" "Detected in some" "Region enriched" "Detected in many" 5 "cerebellum: 40.6" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in many" "Region enriched" "Detected in many" 10 "cerebellum: 132.6" HPA060767 Approved Vesicles "Secreted to extracellular matrix" Vesicles "HPA060767: " "unprognostic (2.17e-1)" "unprognostic (6.45e-4)" "unprognostic (8.60e-2)" "unprognostic (2.65e-5)" "unprognostic (9.85e-2)" "unprognostic (2.51e-4)" "unprognostic (3.37e-2)" "unprognostic (3.61e-2)" "unprognostic (1.56e-1)" "unprognostic (5.07e-4)" "unprognostic (2.86e-2)" "unprognostic (2.34e-1)" "unprognostic (2.23e-2)" "unprognostic (2.13e-3)" "unprognostic (7.76e-2)" "unprognostic (6.91e-3)" "unprognostic (1.21e-5)" 10.1 1.3 1.2 2.6 2.8 0.0 7.9 40.6 2.9 5.0 5.4 0.2 4.2 1.4 3.0 2.7 2.5 2.4 5.4 2.4 2.2 1.7 3.3 0.5 3.1 3.0 1.1 0.6 1.6 4.6 1.1 2.2 13.8 8.5 3.1 2.2 3.3 1.9 1.9 1.6 2.7 4.4 3.3 0.9 0.4 1.7 1.5 0.1 0.0 3.2 1.4 1.6 3.6 7.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.0 2.0 0.5 1.7 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 2.2 0.0 0.1 0.0 8.5 0.0 0.0 0.0 0.0 0.5 1.5 0.0 1.8 1.4 0.0 13.3 0.0 0.0 0.0 0.2 1.2 4.8 0.0 0.0 0.0 0.2 0.0 1.1 0.0 0.7 0.2 0.0 0.0 0.0 0.0 0.1 1.5 0.0 0.3 0.2 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 2.8 40.6 2.9 2.2 1.7 1.1 0.6 8.5 0.1 TLL2 ENSG00000095587 "Tolloid like 2" Q9Y6L7 10 96364606-96513918 "Enzymes, Predicted secreted proteins" Differentiation "Developmental protein, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "heart muscle: 7.4" "Cell line enriched" "Detected in some" 11 "RPTEC TERT1: 21.2" "Low cancer specificity" "Detected in single" "Low region specificity" "Detected in many" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "Secreted - unknown location" "unprognostic (1.28e-2)" "unprognostic (7.54e-4)" "unprognostic (1.50e-1)" "unprognostic (3.31e-3)" "unprognostic (2.67e-1)" "unprognostic (2.14e-3)" "unprognostic (1.31e-2)" "unprognostic (3.52e-4)" "unprognostic (7.08e-2)" "unprognostic (2.50e-1)" "unprognostic (6.71e-2)" "unprognostic (3.37e-2)" "unprognostic (4.98e-4)" "unprognostic (2.90e-1)" "unprognostic (8.41e-2)" "unprognostic (1.95e-4)" "unprognostic (2.30e-1)" 0.7 1.1 3.2 1.4 4.9 1.6 0.7 0.7 5.8 0.8 1.1 5.7 2.5 1.7 1.2 1.1 0.9 0.7 2.6 7.4 3.3 3.8 0.7 0.6 0.5 1.8 3.4 2.1 1.4 1.5 0.4 2.8 1.1 4.6 1.1 1.1 0.0 3.9 2.7 4.1 1.0 2.1 0.9 6.1 0.9 2.1 1.1 5.7 0.0 1.5 4.0 0.7 0.8 0.5 0.9 0.3 0.6 0.2 0.3 0.2 0.0 0.2 0.1 0.4 0.2 0.1 0.0 0.1 0.1 0.0 0.1 0.1 0.0 0.1 0.3 1.1 0.1 0.1 0.2 0.1 0.0 1.9 0.4 0.0 0.2 0.0 0.0 0.0 0.1 0.2 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.1 0.0 1.2 0.1 0.1 0.4 0.0 21.2 0.1 0.8 0.1 0.1 0.0 0.1 0.0 0.0 0.0 0.1 0.4 0.1 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.1 0.2 0.0 0.2 0.9 0.2 0.1 0.0 0.9 0.2 0.2 0.6 0.3 0.2 0.3 0.1 0.0 3.2 4.9 0.7 4.0 3.3 3.8 3.4 2.1 4.6 5.7 TMPRSS11A ECRG1 ENSG00000187054 "Transmembrane serine protease 11A" Q6ZMR5 4 67909385-67964140 "Enzymes, Predicted membrane proteins" "Cell cycle" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "cervix, uterine: 19.5;esophagus: 48.4;lymphoid tissue: 18.7;tongue: 47.6" "Cell line enhanced" "Detected in single" "Daudi: 1.5" "Group enriched" "Detected in some" 9 "cervical cancer: 14.4;head and neck cancer: 11.6;lung cancer: 4.0" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in some" "Not detected" "Not detected" "unprognostic (1.63e-1)" "unprognostic (4.60e-2)" "unprognostic (1.76e-2)" "unprognostic (6.98e-2)" "unprognostic (1.98e-1)" "unprognostic (2.66e-1)" "unprognostic (4.58e-1)" "unprognostic (1.32e-1)" "unprognostic (4.36e-2)" "unprognostic (1.05e-1)" "unprognostic (3.50e-1)" "unprognostic (2.33e-2)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 19.5 0.0 0.0 0.0 0.0 0.0 0.0 48.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 3.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 47.6 18.7 0.3 8.9 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 1.5 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.6 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.4 0.0 0.0 0.2 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 TMPRSS11B ENSG00000185873 "Transmembrane serine protease 11B" Q86T26 4 68226653-68245720 "Enzymes, Predicted membrane proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "esophagus: 138.8;lymphoid tissue: 57.0;tongue: 44.0" "Low cell line specificity" "Detected in some" "Group enriched" "Detected in some" 12 "cervical cancer: 2.6;head and neck cancer: 2.6;stomach cancer: 1.4" "Not detected" "Not detected" "Cell type enhanced" "Detected in single" "neutrophil: 2.4" "Low lineage specificity" "Detected in single" "Not detected" "Not detected" "Not detected" "Not detected" "unprognostic (4.24e-2)" "prognostic favourable (6.91e-4)" "unprognostic (2.92e-1)" "unprognostic (3.96e-1)" 0.1 0.1 0.0 0.1 0.0 0.2 0.1 0.0 0.1 11.2 0.1 0.0 0.0 0.1 0.5 0.1 138.8 0.1 0.1 0.1 0.0 0.0 0.1 0.1 0.1 0.1 0.0 0.0 0.1 0.0 0.1 0.0 0.1 0.0 0.1 0.1 0.0 13.4 0.0 0.1 0.1 0.1 0.1 0.0 0.1 0.1 0.2 0.0 0.0 0.1 44.0 57.0 0.1 23.2 0.7 0.6 2.4 0.5 0.4 0.7 0.0 0.3 1.4 0.8 0.1 0.1 0.0 0.3 0.3 0.1 0.0 0.3 0.8 0.4 1.3 0.1 0.4 1.0 0.2 0.1 0.0 0.1 1.5 0.8 1.8 2.0 0.1 1.1 1.3 0.5 0.2 0.0 0.1 0.0 0.7 2.0 0.1 0.7 0.5 1.3 0.1 1.0 0.6 0.6 0.5 0.2 1.4 0.8 0.3 0.1 0.2 0.1 0.4 0.2 1.3 1.0 0.3 0.5 0.1 0.2 0.9 0.7 0.3 1.0 0.1 0.3 0.4 0.2 0.4 0.1 0.3 0.3 0.3 0.4 0.0 0.7 0.3 0.7 2.4 0.4 0.5 0.6 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 TMPRSS11D ENSG00000153802 "Transmembrane serine protease 11D" O60235 4 67820876-67884032 "Enzymes, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 4 "cervix, uterine: 18.1;esophagus: 41.2;lymphoid tissue: 20.3;tongue: 67.6;vagina: 23.1" "Cell line enhanced" "Detected in single" "RH-30: 1.2" "Group enriched" "Detected in many" 5 "cervical cancer: 36.0;head and neck cancer: 30.0" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA052834 Uncertain "Intracellular and membrane" "HPA052834: " "unprognostic (1.19e-1)" "unprognostic (6.83e-2)" "unprognostic (8.82e-2)" "unprognostic (2.10e-2)" "unprognostic (1.21e-2)" "unprognostic (1.12e-1)" "unprognostic (3.22e-1)" "unprognostic (2.88e-1)" "unprognostic (1.32e-1)" "unprognostic (4.79e-1)" "unprognostic (4.38e-3)" "unprognostic (1.96e-1)" "unprognostic (6.91e-2)" "unprognostic (4.48e-2)" "unprognostic (2.19e-3)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 18.1 0.0 0.0 0.0 0.0 0.6 0.0 41.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 7.6 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.1 0.0 67.6 20.3 0.4 23.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 TMPRSS11E "DESC1, TMPRSS11E2" ENSG00000087128 "Transmembrane serine protease 11E" Q9UL52 4 68447449-68497604 "Enzymes, Predicted membrane proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "esophagus: 103.8;lymphoid tissue: 39.1;tongue: 40.5;vagina: 36.6" "Group enriched" "Detected in some" 6 "HaCaT: 5.8;HBEC3-KT: 2.2" "Group enriched" "Detected in many" 6 "cervical cancer: 22.0;head and neck cancer: 25.3;lung cancer: 11.5;urothelial cancer: 7.6" "Not detected" "Not detected" "Cell type enhanced" "Detected in single" "memory B-cell: 1.8" "Lineage enhanced" "Detected in single" "B-cells: 1.8" "Not detected" "Not detected" "Not detected" "Not detected" HPA051062 Enhanced "Intracellular and membrane" "HPA051062: " "unprognostic (2.53e-1)" "unprognostic (3.10e-1)" "unprognostic (1.84e-1)" "unprognostic (9.14e-2)" "unprognostic (5.03e-2)" "prognostic unfavourable (6.73e-4)" "unprognostic (2.22e-1)" "unprognostic (9.70e-3)" "unprognostic (2.16e-1)" "unprognostic (3.74e-2)" "unprognostic (4.03e-2)" "unprognostic (8.39e-2)" "unprognostic (1.27e-1)" "unprognostic (3.08e-3)" 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 28.9 0.0 0.0 1.2 0.0 1.1 10.5 103.8 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.2 0.0 1.4 0.0 0.0 13.6 0.5 0.0 1.6 0.0 1.2 0.0 0.0 0.0 0.2 0.0 0.1 0.0 40.5 39.1 2.6 36.6 1.8 0.0 0.0 0.0 0.0 0.5 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.5 0.1 0.0 0.0 5.8 0.0 2.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.5 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 1.8 0.5 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 TMPRSS11F FLJ16046 ENSG00000198092 "Transmembrane serine protease 11F" Q6ZWK6 4 68053198-68129880 "Enzymes, Predicted membrane proteins" "Hydrolase, Protease, Serine protease" "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Tissue enhanced" "Detected in some" "esophagus: 18.3;lymphoid tissue: 11.4;skin 1: 10.9;tongue: 13.1" "Group enriched" "Detected in some" 8 "HEL: 2.4;K-562: 5.4;Karpas-707: 1.6;U-266/70: 1.6" "Group enriched" "Detected in some" 7 "cervical cancer: 1.6;head and neck cancer: 2.1;lung cancer: 0.7" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in many" HPA026911 Uncertain "HPA026911: AB_2205589" "unprognostic (9.46e-2)" "unprognostic (5.30e-1)" "unprognostic (7.16e-2)" "unprognostic (8.79e-3)" "unprognostic (1.09e-1)" "unprognostic (2.40e-1)" "unprognostic (1.22e-1)" "unprognostic (5.08e-2)" 0.0 0.0 0.0 0.0 0.0 0.0 1.4 0.0 0.0 5.4 0.0 0.0 0.0 0.0 0.2 0.0 18.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 3.8 0.0 0.1 0.0 0.0 1.4 0.0 0.0 10.9 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.2 0.0 13.1 11.4 0.0 5.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 2.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.4 1.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.6 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 TMPRSS12 "CT151, MGC57341" ENSG00000186452 "Transmembrane serine protease 12" Q86WS5 12 50842920-50887884 "Enzymes, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 32 "testis: 52.7" "Cell line enhanced" "Detected in some" "BEWO: 2.9;Karpas-707: 1.1;NTERA-2: 1.3;SK-BR-3: 1.1" "Not detected" "Not detected" "Not detected" "Not detected" "Cell type enhanced" "Detected in some" "neutrophil: 1.6" "Low lineage specificity" "Detected in single" "Not detected" "Not detected" "Low region specificity" "Detected in some" "unprognostic (1.04e-1)" "unprognostic (9.09e-2)" "unprognostic (3.03e-2)" "unprognostic (7.25e-3)" "unprognostic (1.70e-1)" "unprognostic (1.39e-1)" "unprognostic (3.88e-1)" "unprognostic (2.98e-2)" "unprognostic (2.60e-1)" "unprognostic (1.88e-1)" "unprognostic (1.29e-1)" "unprognostic (5.65e-3)" "unprognostic (1.03e-2)" 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.0 0.0 0.0 52.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.3 1.6 0.1 0.4 0.3 0.0 0.0 0.7 0.0 0.5 0.0 0.0 2.9 0.1 0.0 0.0 0.0 0.1 0.4 0.0 0.1 0.0 0.2 0.0 0.0 0.1 0.0 0.1 0.1 0.3 0.2 0.0 0.2 0.2 0.0 0.0 0.3 0.0 0.0 0.1 1.1 0.0 0.0 0.3 0.4 1.3 0.5 0.1 0.0 0.2 0.0 0.3 0.3 0.1 0.6 1.1 0.0 0.1 0.2 0.2 0.3 0.0 0.0 0.0 0.4 0.1 0.1 0.3 0.2 0.2 1.3 0.1 0.5 0.2 0.0 0.1 0.1 0.2 0.1 0.0 0.4 0.3 0.3 1.6 0.4 0.1 0.3 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 TMPRSS13 "MSPL, TMPRSS11" ENSG00000137747 "Transmembrane serine protease 13" Q9BYE2 11 117900643-117929459 "Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "placenta: 22.1;salivary gland: 16.6;skin 1: 26.0" "Cell line enhanced" "Detected in some" "A-431: 7.3;BEWO: 17.5;MCF7: 14.7;SK-BR-3: 25.3;T-47d: 25.8" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Not detected" "Not detected" "Low region specificity" "Detected in many" "unprognostic (1.08e-3)" "unprognostic (5.18e-2)" "unprognostic (6.59e-2)" "unprognostic (1.06e-3)" "unprognostic (1.04e-1)" "unprognostic (1.01e-1)" "unprognostic (3.64e-1)" "unprognostic (5.61e-2)" "unprognostic (1.20e-1)" "unprognostic (1.49e-1)" "unprognostic (1.92e-2)" "unprognostic (2.03e-1)" "unprognostic (3.16e-6)" "unprognostic (2.05e-1)" "unprognostic (7.75e-2)" "unprognostic (1.08e-1)" "unprognostic (3.44e-1)" 0.2 0.3 0.2 0.6 0.2 0.3 6.2 0.2 0.2 5.8 0.2 0.2 0.2 0.2 0.9 0.7 14.8 0.1 0.2 0.2 0.4 0.0 0.7 0.2 4.0 0.7 0.2 0.2 0.3 5.7 0.0 0.5 22.1 0.2 0.9 0.2 0.6 16.6 0.2 0.2 26.0 0.5 0.2 0.2 1.0 0.1 0.3 0.2 0.4 9.5 13.7 10.6 0.3 5.6 1.0 2.6 1.0 0.7 1.9 1.2 0.8 7.3 0.0 0.0 0.0 0.0 0.0 17.5 0.0 0.0 0.0 0.0 5.6 0.1 0.4 0.0 0.0 0.8 0.0 0.0 0.0 0.5 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.3 0.4 0.0 14.7 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 2.0 0.2 0.0 0.0 25.3 0.3 25.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.1 0.0 1.0 0.6 0.0 0.9 0.7 0.0 1.0 0.1 1.2 1.8 0.5 0.4 0.1 0.0 1.9 0.5 2.6 0.7 0.8 0.2 0.2 0.2 0.2 0.4 0.0 0.2 0.2 0.2 0.2 TMPRSS15 "ENTK, MGC133046, PRSS7" ENSG00000154646 "Transmembrane serine protease 15" P98073 21 18269116-18485879 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 67 "intestine: 154.6" "Group enriched" "Detected in some" 20 "U-138 MG: 19.8;U-87 MG: 55.3" "Group enriched" "Detected in some" 12 "liver cancer: 0.7;pancreatic cancer: 1.5;stomach cancer: 1.5" "Not detected" "Not detected" "Cell type enhanced" "Detected in single" "naive B-cell: 2.3" "Low lineage specificity" "Detected in single" "Not detected" "Not detected" "Region enriched" "Detected in many" 5 "olfactory region: 9.3" "HPA015611, HPA034857, HPA072934" Enhanced Approved "Nucleoli,Plasma membrane" "Plasma membrane" Nucleoli "HPA015611: AB_1855791, HPA034857: , HPA072934: " "unprognostic (9.26e-2)" "unprognostic (4.14e-1)" "unprognostic (3.52e-1)" "unprognostic (8.33e-2)" "unprognostic (1.19e-1)" "unprognostic (7.20e-2)" "unprognostic (4.70e-2)" "unprognostic (6.35e-2)" "unprognostic (5.92e-2)" 0.1 0.0 0.1 0.1 0.1 0.0 0.1 0.0 0.0 0.0 80.5 0.0 0.0 154.6 0.1 0.0 0.0 0.0 0.0 0.1 0.1 0.1 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 42.4 0.0 0.1 0.1 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.1 2.3 0.0 0.5 0.1 0.6 0.3 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.5 0.0 0.0 1.9 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 1.6 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 19.8 0.0 0.1 0.0 0.3 0.0 0.0 55.3 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.3 0.3 0.1 0.5 0.6 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.1 0.1 0.1 0.0 0.0 0.0 TMPRSS2 PRSS10 ENSG00000184012 "Transmembrane serine protease 2" O15393 21 41464551-41531116 "Cancer-related genes, Enzymes, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Protease, Serine protease" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 75.6;pancreas: 64.5;prostate: 68.2" "Cell line enhanced" "Detected in some" "CACO-2: 14.6;MCF7: 6.3;RT4: 35.2;SK-BR-3: 7.2;T-47d: 5.4" "Cancer enriched" "Detected in many" 7 "prostate cancer: 250.6" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "HPA034493, HPA035787" Enhanced Supported "Nucleoplasm,Cell Junctions" "Intracellular and membrane" "Cell Junctions" Nucleoplasm "HPA034493: , HPA035787: AB_2674782" "unprognostic (4.80e-3)" "unprognostic (3.49e-1)" "unprognostic (2.16e-1)" "prognostic favourable (2.56e-4)" "unprognostic (1.72e-1)" "unprognostic (1.05e-2)" "unprognostic (4.28e-2)" "unprognostic (1.51e-3)" "unprognostic (9.43e-2)" "unprognostic (9.02e-3)" "unprognostic (6.24e-2)" "unprognostic (6.43e-2)" "prognostic favourable (7.86e-6)" "unprognostic (2.00e-2)" "unprognostic (1.68e-1)" "unprognostic (1.41e-1)" "unprognostic (2.15e-2)" 0.2 0.1 0.2 15.5 0.4 0.0 6.1 0.2 0.5 1.3 38.7 0.4 24.4 17.5 0.5 0.9 10.7 2.2 17.3 0.2 0.3 0.1 19.4 18.4 20.7 0.2 0.2 0.2 0.7 64.5 0.0 1.3 1.0 0.4 68.2 18.5 0.3 52.3 35.7 0.2 2.1 75.6 0.9 0.2 0.3 36.7 0.8 0.3 0.5 19.9 3.9 10.2 5.9 4.3 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 1.3 0.0 0.0 0.0 0.0 14.6 1.9 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.3 0.1 0.5 1.3 0.0 0.0 0.0 1.4 0.6 35.2 0.0 0.4 0.0 7.2 0.1 5.4 0.0 0.0 0.0 0.3 0.3 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.2 0.4 0.2 0.5 0.3 0.1 0.2 0.2 0.4 0.3 TMPRSS3 "DFNB10, DFNB8" ENSG00000160183 "Transmembrane serine protease 3" P57727 21 42371837-42396846 "Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted membrane proteins" "Hydrolase, Protease, Serine protease" "Cancer-related genes, Deafness, Disease mutation, Non-syndromic deafness" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "fallopian tube: 24.7" "Group enriched" "Detected in some" 5 "HEL: 18.3;U-266/84: 73.4" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Cell type enhanced" "Detected in many" "MAIT T-cell: 6.3" "Lineage enriched" "Detected in single" 7 "T-cells: 6.3" "Region enriched" "Detected in single" 7 "cerebellum: 0.9" "Not detected" "Not detected" "unprognostic (8.47e-3)" "unprognostic (2.83e-1)" "prognostic unfavourable (3.64e-4)" "unprognostic (2.85e-1)" "unprognostic (2.45e-3)" "unprognostic (3.97e-2)" "unprognostic (1.43e-1)" "unprognostic (8.17e-2)" "unprognostic (9.62e-2)" "unprognostic (4.81e-2)" "unprognostic (2.65e-1)" "unprognostic (1.42e-1)" "prognostic unfavourable (8.24e-4)" "unprognostic (2.66e-2)" "unprognostic (2.73e-1)" "unprognostic (8.00e-2)" "unprognostic (1.33e-1)" 1.8 0.7 8.6 0.3 7.7 0.3 9.4 0.3 7.1 6.8 0.4 0.0 0.0 1.7 0.9 0.4 0.4 24.7 8.6 0.2 1.8 1.6 3.5 3.5 3.7 0.6 3.7 2.0 2.8 7.4 0.2 5.8 5.7 3.3 0.8 0.4 2.4 12.3 0.6 0.3 0.6 1.3 0.2 0.2 0.6 15.9 0.2 0.8 0.0 9.8 0.2 0.6 1.9 0.0 0.0 0.1 0.7 0.8 0.0 6.3 1.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.5 0.0 0.2 0.0 0.0 0.0 0.0 0.0 9.0 0.0 18.3 7.7 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.0 0.0 0.4 0.9 0.0 0.0 0.1 0.0 0.0 0.0 0.8 0.4 0.0 0.0 9.5 0.4 0.0 0.9 0.1 0.0 0.0 0.5 0.0 0.0 0.2 73.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.5 0.2 6.3 0.0 3.5 3.6 0.1 0.0 0.7 1.8 0.7 0.0 0.8 0.0 1.6 1.0 8.6 7.7 0.3 7.1 1.8 1.6 3.7 2.0 3.3 0.8 TMPRSS4 "MT-SP2, TMPRSS3" ENSG00000137648 "Transmembrane serine protease 4" Q9NRS4 11 118077012-118121890 "Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "esophagus: 60.9;gallbladder: 45.4;lymphoid tissue: 41.0;urinary bladder: 43.9" "Cell line enhanced" "Detected in some" "CAPAN-2: 44.9;HaCaT: 19.2;RPTEC TERT1: 31.5;RT4: 39.3" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Cell type enriched" "Detected in single" 5 "basophil: 4.5" "Lineage enriched" "Detected in single" 6 "granulocytes: 4.5" "Not detected" "Not detected" "Low region specificity" "Detected in all" HPA006238 Uncertain Approved Nucleoplasm,Cytosol Nucleoplasm Cytosol "HPA006238: AB_1080316" "unprognostic (1.48e-1)" "unprognostic (3.27e-2)" "unprognostic (1.19e-2)" "unprognostic (1.23e-1)" "unprognostic (5.23e-2)" "unprognostic (5.50e-2)" "unprognostic (8.17e-3)" "unprognostic (1.95e-2)" "unprognostic (2.41e-1)" "unprognostic (9.62e-2)" "prognostic unfavourable (3.14e-4)" "unprognostic (2.87e-3)" "unprognostic (2.80e-1)" "unprognostic (4.58e-2)" "unprognostic (1.06e-1)" "unprognostic (1.10e-2)" "unprognostic (9.96e-3)" 0.3 0.3 0.2 14.2 0.3 0.0 0.3 0.3 0.2 11.4 23.5 0.1 0.0 16.1 3.1 2.8 60.9 0.6 45.4 0.3 0.3 0.3 17.7 0.3 3.2 0.0 0.2 0.0 0.3 0.4 0.0 0.3 0.8 0.1 9.9 26.2 0.2 4.0 0.0 0.3 2.4 27.4 4.2 0.2 0.3 13.7 0.7 0.0 0.6 0.3 13.7 41.0 43.9 22.3 0.5 0.1 4.5 0.7 0.2 0.1 0.0 8.9 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 2.0 44.9 0.0 1.7 0.0 19.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 1.2 0.1 0.0 0.4 0.1 1.3 0.0 0.0 0.0 0.0 0.0 31.5 39.3 0.0 0.0 0.0 3.4 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 4.5 0.1 0.3 0.1 0.1 0.1 0.2 0.1 0.1 0.0 0.5 0.1 0.1 0.9 0.2 0.7 0.1 0.1 0.0 0.2 0.3 0.3 0.2 0.3 0.3 0.2 0.0 0.1 0.0 TMPRSS5 "MGC141886, MGC148044" ENSG00000166682 "Transmembrane serine protease 5" Q9H3S3 11 113687546-113706373 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 5 "brain: 24.0;salivary gland: 15.0;skeletal muscle: 6.0" "Cell line enhanced" "Detected in some" "AF22: 4.4;CAPAN-2: 7.1;WM-115: 5.8" "Cancer enhanced" "Detected in some" "glioma: 5.3" "Low region specificity" "Detected in all" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" HPA010992 Approved Nucleoplasm Nucleoplasm "HPA010992: AB_1858152" "unprognostic (1.53e-2)" "unprognostic (3.81e-2)" "unprognostic (2.97e-1)" "unprognostic (1.05e-1)" "unprognostic (1.93e-1)" "unprognostic (8.73e-2)" "unprognostic (2.99e-3)" "unprognostic (3.08e-1)" "unprognostic (5.19e-3)" "unprognostic (8.49e-2)" "unprognostic (8.13e-2)" "unprognostic (3.38e-2)" "unprognostic (1.96e-3)" "unprognostic (1.18e-1)" "unprognostic (1.75e-1)" "unprognostic (1.80e-1)" "unprognostic (4.04e-3)" 2.1 1.7 10.8 1.0 24.0 3.2 2.2 2.1 14.8 1.2 1.0 21.6 0.0 1.0 1.2 0.9 1.8 1.1 2.2 1.2 11.5 5.7 0.9 0.9 0.9 1.1 11.6 12.7 1.4 1.2 0.6 1.5 1.2 16.5 1.2 1.3 0.9 15.0 1.4 6.0 2.7 0.7 1.2 16.9 1.1 2.4 2.3 8.8 0.0 1.1 0.4 1.3 0.9 0.4 0.5 0.0 0.0 0.0 0.0 0.1 0.0 0.5 0.8 4.4 2.5 0.5 0.4 0.6 1.2 0.5 0.6 0.9 2.5 7.1 0.3 3.2 0.5 0.8 0.4 0.4 0.3 0.5 1.3 1.0 0.6 0.0 0.3 1.0 0.8 0.6 0.6 0.6 1.2 0.8 0.8 0.5 0.9 0.0 0.8 1.2 0.5 0.2 0.9 0.5 0.0 0.7 0.4 0.6 1.0 0.5 0.1 3.5 0.5 0.6 0.5 0.9 1.7 0.6 0.7 0.5 0.2 0.1 0.4 0.9 5.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 10.8 24.0 2.1 12.3 11.5 5.7 11.6 12.7 16.5 8.8 TMPRSS6 FLJ30744 ENSG00000187045 "Transmembrane serine protease 6" Q8IU80 22 37065436-37109563 "Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Protease, Serine protease" "Disease mutation" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 11 "liver: 59.3" "Group enriched" "Detected in some" 4 "Hep G2: 7.5;SCLC-21H: 12.9" "Group enriched" "Detected in many" 14 "liver cancer: 51.3;thyroid cancer: 14.1" "Region enriched" "Detected in single" 10 "basal ganglia: 1.8" "Cell type enhanced" "Detected in single" "memory CD8 T-cell: 1.3" "Low lineage specificity" "Detected in single" "Low region specificity" "Detected in single" "Region enriched" "Detected in single" 5 "basal ganglia: 2.2" "unprognostic (3.93e-1)" "unprognostic (3.28e-1)" "unprognostic (8.62e-2)" "unprognostic (6.29e-5)" "unprognostic (7.95e-2)" "unprognostic (1.62e-1)" "prognostic favourable (8.16e-6)" "unprognostic (2.44e-1)" "unprognostic (3.07e-1)" "unprognostic (2.41e-1)" "unprognostic (1.16e-2)" "unprognostic (3.58e-2)" "unprognostic (1.15e-7)" "unprognostic (2.38e-1)" "unprognostic (9.15e-2)" "unprognostic (2.39e-2)" "unprognostic (3.86e-5)" 0.1 0.0 0.1 0.1 1.8 0.0 0.8 0.1 0.1 0.1 0.3 0.1 0.1 1.1 0.1 0.4 0.1 0.2 0.4 0.1 0.1 0.0 0.1 59.3 1.9 0.1 0.1 0.1 0.5 0.9 0.0 5.3 0.6 0.1 0.2 0.2 0.1 0.1 0.1 0.1 1.1 0.6 0.1 0.1 0.1 2.3 2.6 0.1 0.2 0.1 0.1 0.1 0.1 0.1 0.7 0.1 0.0 0.1 0.0 1.3 0.0 0.2 0.8 0.2 0.4 0.0 0.0 0.6 0.2 0.0 0.0 0.0 0.4 0.0 0.1 0.3 0.0 0.0 0.0 0.0 0.0 1.8 2.3 0.3 0.1 7.5 0.0 0.2 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.6 0.0 1.3 0.0 0.0 0.3 0.1 0.4 0.2 0.3 0.0 0.0 12.9 0.4 0.2 1.0 0.0 0.1 0.0 0.6 0.5 1.6 0.1 0.0 1.5 0.4 0.1 0.4 0.1 0.0 0.0 0.1 0.0 0.4 0.0 0.8 0.5 0.2 1.3 0.1 0.7 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 1.8 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.1 TMPRSS7 ENSG00000176040 "Transmembrane serine protease 7" Q7RTY8 3 112034843-112081269 "Enzymes, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Protease, Serine protease" "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Tissue enhanced" "Detected in some" "blood: 2.2;testis: 5.2" "Cell line enhanced" "Detected in some" "HaCaT: 1.4;hTCEpi: 2.7;RT4: 1.3;U-266/70: 1.8" "Not detected" "Not detected" "Low cell type specificity" "Detected in some" "Low lineage specificity" "Detected in single" "Low region specificity" "Detected in many" "Low region specificity" "Detected in some" HPA040630 Uncertain "HPA040630: AB_10796124" "unprognostic (4.02e-2)" "unprognostic (9.87e-2)" "unprognostic (9.05e-2)" "unprognostic (2.16e-2)" "unprognostic (2.24e-1)" "unprognostic (4.64e-3)" "unprognostic (6.63e-2)" "unprognostic (2.16e-1)" "unprognostic (2.29e-2)" "unprognostic (4.64e-1)" "unprognostic (1.68e-1)" "unprognostic (1.94e-1)" "unprognostic (7.23e-2)" "unprognostic (2.96e-1)" "unprognostic (2.06e-2)" 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.3 0.2 0.0 0.1 0.4 0.0 0.0 0.0 1.5 0.1 0.0 0.1 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.7 0.0 0.8 0.0 0.0 0.2 0.1 0.1 0.0 0.5 0.8 0.0 0.0 0.0 1.0 5.2 0.3 0.0 0.2 0.0 0.8 0.5 2.2 0.3 0.5 0.7 0.1 0.3 0.0 0.7 0.2 0.4 0.1 0.9 0.6 0.7 0.2 0.5 0.6 0.2 0.0 0.0 0.0 1.4 0.0 0.9 0.6 0.0 0.0 0.5 0.3 0.0 0.0 0.0 0.0 0.0 2.7 0.1 0.8 0.0 0.0 0.0 0.2 0.0 0.4 0.1 0.1 0.4 0.0 0.8 0.0 0.5 1.3 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.3 0.0 0.3 0.0 0.0 1.8 0.0 0.2 0.0 0.0 0.0 2.2 0.3 0.7 0.2 0.2 0.1 0.6 0.3 0.2 0.0 0.8 0.7 0.2 1.7 0.5 0.2 0.5 0.2 0.1 TMPRSS9 ENSG00000178297 "Transmembrane serine protease 9" Q7Z410 19 2389771-2426239 "Enzymes, Predicted membrane proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "liver: 6.3;lymphoid tissue: 4.6;testis: 5.9" "Cell line enhanced" "Detected in some" "Karpas-707: 6.1;SK-BR-3: 3.1;U-266/70: 5.4" "Low cancer specificity" "Detected in some" "Cell type enhanced" "Detected in single" "eosinophil: 2.4" "Lineage enhanced" "Detected in single" "granulocytes: 2.4" "Region enhanced" "Detected in single" "basal ganglia: 0.5" "Low region specificity" "Detected in all" HPA051483 Uncertain "HPA051483: " "unprognostic (1.63e-1)" "unprognostic (1.94e-2)" "unprognostic (5.62e-3)" "unprognostic (1.86e-1)" "unprognostic (1.54e-2)" "unprognostic (1.87e-3)" "unprognostic (3.30e-1)" "unprognostic (6.44e-2)" "unprognostic (7.29e-2)" "unprognostic (2.07e-1)" "unprognostic (6.30e-2)" "unprognostic (9.20e-3)" "unprognostic (2.28e-3)" "unprognostic (8.67e-2)" "unprognostic (1.96e-1)" "unprognostic (3.07e-3)" "unprognostic (6.73e-2)" 0.1 1.1 0.9 0.4 0.2 2.0 1.3 0.0 0.2 0.0 0.4 0.3 0.4 0.0 0.0 0.1 0.3 0.0 0.1 0.1 0.0 6.3 0.0 0.1 0.0 0.2 1.2 0.0 0.2 0.1 0.1 0.0 0.5 0.0 1.5 1.8 0.4 0.0 0.0 4.6 0.1 5.9 0.0 0.0 0.0 0.0 0.0 0.9 2.4 0.0 0.0 0.0 0.1 1.7 0.3 0.2 0.6 0.0 0.0 0.5 0.8 0.0 0.0 0.0 0.6 0.5 0.4 0.6 0.0 1.2 0.0 0.0 0.0 0.0 0.8 0.2 2.1 2.3 0.0 2.3 0.3 0.0 0.0 0.0 0.0 0.0 1.0 6.1 0.0 1.2 0.1 0.4 0.5 0.8 1.1 0.0 0.8 0.0 0.3 0.1 0.2 0.2 3.1 0.1 0.4 1.6 0.4 1.1 0.8 1.1 0.7 5.4 1.3 1.5 0.2 0.9 0.2 0.0 0.0 2.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.1 TNFAIP3 "A20, OTUD7C" ENSG00000118503 "TNF alpha induced protein 3" P21580 6 137867188-137883312 "Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Apoptosis, Inflammatory response, Ubl conjugation pathway" "DNA-binding, Hydrolase, Multifunctional enzyme, Protease, Thiol protease, Transferase" "Cancer-related genes, Disease mutation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 112.4" "Cell line enhanced" "Detected in many" "Karpas-707: 48.4;REH: 42.0;U-266/84: 36.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Not detected" "Not detected" "Low region specificity" "Detected in many" "HPA002116, HPA067479" Approved Supported Vesicles Vesicles "HPA002116: AB_1858162, HPA067479: " "unprognostic (5.50e-3)" "unprognostic (9.98e-3)" "unprognostic (3.06e-2)" "unprognostic (1.01e-2)" "unprognostic (4.01e-2)" "unprognostic (9.47e-2)" "unprognostic (5.01e-3)" "unprognostic (4.40e-2)" "unprognostic (2.92e-2)" "unprognostic (2.58e-1)" "unprognostic (1.72e-1)" "unprognostic (2.06e-1)" "prognostic unfavourable (6.05e-4)" "unprognostic (6.06e-2)" "unprognostic (3.55e-3)" "unprognostic (1.27e-1)" "unprognostic (6.29e-2)" 27.4 6.0 1.5 58.6 1.8 112.4 17.2 0.4 1.5 7.7 15.7 3.2 2.6 5.1 9.7 7.3 12.7 12.1 17.0 11.7 2.1 1.3 6.8 8.1 45.1 38.8 2.1 2.6 37.5 7.2 2.1 3.7 14.5 4.6 13.8 6.3 7.2 8.2 3.5 10.7 20.5 17.2 8.2 3.8 25.9 8.0 9.3 2.1 38.6 5.7 9.2 31.4 23.3 9.5 7.1 18.6 10.0 9.7 7.5 20.5 9.0 8.9 1.5 0.5 0.8 3.0 5.1 2.1 5.1 20.0 1.4 1.8 9.9 3.0 2.0 13.2 5.9 6.8 0.3 14.8 2.6 14.6 0.5 2.0 5.2 5.8 3.3 2.7 3.7 4.7 2.1 16.9 16.1 0.8 4.1 48.4 2.4 0.5 14.7 11.5 0.3 0.4 42.0 10.4 1.4 4.4 4.3 0.2 0.0 1.0 1.5 4.4 1.0 3.4 4.0 14.5 1.7 12.9 2.9 15.6 36.1 4.1 5.3 3.5 1.8 5.6 9.7 5.5 14.8 7.1 20.5 6.2 15.1 13.3 10.3 7.1 10.0 7.4 10.0 7.5 3.7 18.6 14.7 9.0 1.5 1.8 0.4 1.5 2.1 1.3 2.1 2.6 4.6 2.1 TPP2 TPPII ENSG00000134900 "Tripeptidyl peptidase 2" P29144 13 102597003-102679958 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Aminopeptidase, Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA021069, HPA049630" Approved Supported "Nuclear bodies,Cytosol" 410000 "Nuclear bodies, Cytosol" "HPA021069: AB_1858344, HPA049630: " "unprognostic (4.75e-2)" "unprognostic (4.78e-2)" "unprognostic (9.97e-2)" "unprognostic (1.08e-1)" "unprognostic (2.01e-2)" "unprognostic (4.43e-2)" "unprognostic (2.45e-2)" "unprognostic (8.33e-3)" "unprognostic (5.02e-2)" "unprognostic (1.51e-1)" "unprognostic (3.12e-1)" "unprognostic (2.75e-3)" "unprognostic (6.26e-2)" "unprognostic (3.12e-1)" "unprognostic (7.53e-2)" "unprognostic (3.95e-2)" "unprognostic (3.43e-3)" 19.9 12.4 10.8 21.4 14.5 24.7 18.1 23.1 18.4 16.8 14.7 12.2 50.3 13.1 20.0 21.8 14.4 16.7 13.5 17.0 11.7 9.7 12.9 22.8 18.4 32.8 11.7 13.8 21.6 16.3 15.7 15.7 19.2 15.3 13.9 21.0 12.9 15.6 34.5 35.7 14.1 17.4 19.2 13.4 20.7 15.4 34.5 14.0 23.8 21.9 16.0 19.7 17.0 16.0 6.0 5.8 9.2 6.9 10.9 12.1 4.7 15.9 6.4 18.5 15.7 12.5 17.3 13.2 16.3 11.9 10.5 13.2 13.5 21.5 17.5 5.6 13.1 15.7 14.3 11.5 19.0 12.2 12.7 33.3 16.8 10.8 10.6 37.6 20.3 13.4 5.2 11.8 15.8 15.0 19.8 19.6 14.8 5.0 17.3 28.2 15.0 8.9 19.2 14.0 15.8 13.6 13.2 17.2 14.1 10.2 17.1 7.3 9.8 42.2 12.0 10.0 7.3 6.4 13.5 19.3 23.3 15.3 16.7 27.2 12.9 9.2 6.0 4.0 9.1 6.9 10.7 6.0 10.3 10.1 5.8 5.5 12.1 11.5 1.3 10.9 5.7 4.6 10.9 4.7 10.8 14.5 23.1 18.4 11.7 9.7 11.7 13.8 15.3 14.0 TPSAB1 "TPS1, TPS2, TPSB1" ENSG00000172236 "Tryptase alpha/beta 1" Q15661 16 1240696-1242554 "Enzymes, Predicted intracellular proteins, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell line enriched" "Detected in some" 173 "HMC-1: 294.1" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Cell type enriched" "Detected in single" 308 "basophil: 30.8" "Lineage enriched" "Detected in single" 308 "granulocytes: 30.8" "CAB016369, CAB022175, HPA049153, HPA049554" Supported "Secreted to blood" "CAB016369: AB_628406, CAB022175: , HPA049153: , HPA049554: " "unprognostic (2.06e-2)" "unprognostic (5.14e-2)" "unprognostic (2.02e-3)" "unprognostic (1.64e-2)" "unprognostic (9.31e-3)" "prognostic favourable (9.62e-6)" "unprognostic (1.02e-1)" "unprognostic (4.08e-2)" "unprognostic (1.80e-1)" "unprognostic (1.43e-1)" "unprognostic (2.24e-1)" "unprognostic (2.83e-2)" "unprognostic (4.13e-2)" "unprognostic (2.23e-1)" "unprognostic (2.81e-2)" "unprognostic (1.16e-1)" "unprognostic (1.36e-2)" 22.4 0.2 1.6 5.8 1.6 0.0 10.6 1.6 1.6 13.9 17.1 1.6 1.6 17.7 18.7 10.4 15.2 6.1 33.1 4.7 1.6 0.0 4.4 2.8 29.2 16.8 1.6 1.6 2.9 4.5 0.0 1.6 1.9 1.6 24.1 10.0 5.1 14.6 6.3 3.6 29.9 31.0 15.0 1.6 1.6 24.5 5.1 1.6 3.1 3.7 3.8 6.9 21.6 16.0 0.0 0.0 30.8 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 1.6 0.0 0.0 0.0 0.1 294.1 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.1 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 1.6 0.1 30.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 1.6 1.6 1.6 1.6 1.6 0.0 1.6 1.6 1.6 1.6 TPSB2 ENSG00000197253 "Tryptase beta 2 (gene/pseudogene)" P20231 16 1227272-1230184 "Enzymes, Predicted secreted proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "gallbladder: 16.2" "Cell line enriched" "Detected in some" 8 "HMC-1: 81.3" "Low cancer specificity" "Detected in many" "Cell type enriched" "Detected in single" 84 "basophil: 8.4" "Lineage enriched" "Detected in single" 84 "granulocytes: 8.4" "HPA049153, HPA049554" Supported "Secreted to blood" 7500000 "HPA049153: , HPA049554: " "unprognostic (9.05e-2)" "unprognostic (8.46e-3)" "unprognostic (2.42e-3)" "unprognostic (2.27e-2)" "unprognostic (4.97e-3)" "unprognostic (1.02e-3)" "unprognostic (1.11e-1)" "unprognostic (8.55e-2)" "unprognostic (2.48e-1)" "unprognostic (2.24e-1)" "unprognostic (1.95e-1)" "unprognostic (8.30e-3)" "unprognostic (1.91e-2)" "unprognostic (5.76e-2)" "unprognostic (2.41e-2)" "unprognostic (4.65e-2)" "unprognostic (3.17e-2)" 1.8 0.0 0.9 1.9 0.9 0.0 4.1 0.9 0.9 8.8 5.3 0.9 0.9 4.9 2.9 0.9 7.7 0.1 16.2 0.9 0.9 0.9 0.9 12.3 2.4 0.9 0.9 0.9 1.3 0.0 0.9 0.9 0.9 2.7 2.3 0.9 6.2 1.2 0.9 3.4 9.7 4.4 0.9 0.9 13.6 0.9 0.9 0.9 0.9 0.9 0.9 4.2 0.9 0.0 0.0 8.4 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 10.4 0.0 0.0 0.0 0.1 81.3 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 8.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 TPSD1 ENSG00000095917 "Tryptase delta 1" Q9BZJ3 16 1256059-1258998 "Enzymes, Predicted intracellular proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Group enriched" "Detected in some" 48 "HEL: 18.3;HMC-1: 27.9" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Cell type enriched" "Detected in single" 65 "basophil: 6.4" "Lineage enriched" "Detected in single" 65 "granulocytes: 6.4" "CAB002215, CAB032871, HPA040182, HPA049554" Supported Uncertain "Nuclear speckles" "Intracellular and membrane" "Nuclear speckles" "CAB002215: AB_563870, CAB032871: AB_2206475, HPA040182: , HPA049554: " "unprognostic (5.99e-2)" "unprognostic (3.00e-1)" "unprognostic (1.38e-1)" "unprognostic (1.04e-2)" "unprognostic (8.97e-3)" "unprognostic (1.15e-4)" "unprognostic (1.70e-1)" "unprognostic (5.45e-2)" "unprognostic (9.00e-2)" "unprognostic (2.88e-1)" "unprognostic (4.30e-1)" "unprognostic (2.94e-2)" "unprognostic (2.50e-3)" "unprognostic (3.74e-2)" "unprognostic (4.14e-1)" "unprognostic (3.89e-1)" "unprognostic (7.46e-3)" 6.6 0.1 0.6 3.8 0.6 0.8 3.7 0.6 0.8 3.2 5.6 0.6 0.6 2.7 7.5 3.3 7.6 2.3 13.0 2.0 0.6 0.0 1.3 2.3 17.0 13.7 0.6 0.6 0.6 0.9 0.1 0.6 0.9 0.6 4.3 0.4 3.1 3.6 0.7 1.6 7.8 9.3 4.7 0.6 0.6 15.7 3.5 0.6 1.6 1.1 2.8 2.6 8.9 6.6 0.0 0.0 6.4 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 18.3 0.0 0.0 0.0 0.1 27.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.4 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.6 0.6 0.8 0.6 0.0 0.6 0.6 0.6 0.6 TPSG1 "PRSS31, TMT" ENSG00000116176 "Tryptase gamma 1" Q9NRR2 16 1221651-1225257 "Enzymes, Predicted membrane proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Tissue enhanced" "Detected in many" "intestine: 16.0" "Group enriched" "Detected in some" 9 "HMC-1: 22.3;MCF7: 7.2" "Cancer enhanced" "Detected in many" "colorectal cancer: 5.2" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA060458 Enhanced "HPA060458: " "unprognostic (1.86e-1)" "unprognostic (3.46e-1)" "unprognostic (5.21e-3)" "unprognostic (1.27e-1)" "unprognostic (5.58e-2)" "unprognostic (1.18e-2)" "unprognostic (3.45e-2)" "unprognostic (4.60e-2)" "unprognostic (9.97e-2)" "unprognostic (1.34e-1)" "unprognostic (8.92e-2)" "unprognostic (6.39e-2)" "prognostic unfavourable (1.76e-8)" "unprognostic (2.19e-1)" "unprognostic (1.70e-1)" "unprognostic (8.65e-4)" "unprognostic (5.70e-2)" 1.3 0.6 0.4 4.5 0.4 0.0 3.1 0.4 0.4 0.6 14.4 0.4 0.4 14.0 1.2 0.4 0.7 0.5 1.0 0.4 0.4 0.0 0.4 0.4 0.6 0.4 0.4 0.4 2.0 0.4 0.0 3.2 0.4 0.4 1.1 8.8 0.4 0.4 0.4 0.4 1.1 16.0 1.2 0.4 0.4 1.0 1.3 0.4 0.4 0.4 1.1 0.4 1.4 2.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 1.0 0.0 0.9 0.0 0.1 0.0 0.0 0.0 0.0 0.1 1.2 0.0 0.0 0.0 0.0 22.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 7.2 0.0 0.0 0.7 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.6 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.4 0.4 0.4 0.4 0.0 0.4 0.4 0.4 0.4 TRHDE "PAP-II, PGPEP2, TRH-DE" ENSG00000072657 "Thyrotropin releasing hormone degrading enzyme" Q9UKU6 12 72087266-72670757 "Enzymes, Predicted intracellular proteins, Predicted membrane proteins" "Aminopeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 30.3;pancreas: 19.4" "Cell line enhanced" "Detected in some" "BJ: 20.5;BJ hTERT+: 19.9;EFO-21: 10.7;HBF TERT88: 7.3" "Cancer enhanced" "Detected in some" "renal cancer: 1.9" "Region enhanced" "Detected in many" "cerebellum: 30.3" "Cell type enhanced" "Detected in single" "basophil: 1.0" "Low lineage specificity" "Detected in single" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" 6200000 "unprognostic (3.56e-2)" "unprognostic (4.06e-3)" "unprognostic (6.01e-2)" "unprognostic (1.44e-6)" "unprognostic (1.77e-1)" "unprognostic (6.37e-2)" "unprognostic (7.79e-2)" "unprognostic (6.96e-2)" "unprognostic (3.99e-2)" "unprognostic (1.48e-1)" "unprognostic (5.14e-4)" "unprognostic (2.40e-1)" "prognostic favourable (1.53e-7)" "unprognostic (2.55e-2)" "unprognostic (2.48e-1)" "unprognostic (8.91e-3)" "unprognostic (2.94e-2)" 6.2 2.2 2.9 1.0 4.7 1.0 7.6 30.3 12.3 10.2 2.4 0.1 2.5 4.8 2.7 1.7 0.9 2.5 2.5 2.2 7.3 2.8 9.9 1.5 3.0 0.6 1.2 5.5 6.5 19.4 0.4 1.6 0.7 1.5 5.5 1.5 1.0 2.4 5.8 0.7 0.8 4.2 1.2 0.9 4.8 1.1 1.7 0.5 0.0 0.5 0.4 1.0 2.8 7.6 0.2 0.0 1.0 0.3 0.3 0.0 0.0 2.4 0.0 0.4 0.0 1.1 0.0 6.6 20.5 19.9 2.0 1.3 0.0 0.0 0.0 10.7 2.9 0.2 3.7 0.0 7.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.7 0.0 0.0 1.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 5.9 0.0 0.0 0.0 6.8 4.5 2.0 0.0 0.0 0.0 0.0 0.0 3.9 0.0 0.0 2.2 0.0 0.3 0.0 0.0 0.0 0.0 0.4 0.0 1.0 0.1 0.2 0.0 0.3 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.8 0.3 0.0 0.0 0.0 0.0 2.9 4.7 30.3 12.3 7.3 2.8 1.2 5.5 1.5 0.5 TYSND1 "MGC34695, NET41" ENSG00000156521 "Trypsin domain containing 1" Q2T9J0 10 70137981-70146676 "Enzymes, Predicted intracellular proteins" "Hydrolase, Protease, Serine protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "testis: 40.7" "Cell line enhanced" "Detected in many" "HaCaT: 17.7;PC-3: 27.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA030304 Approved Uncertain Nucleoplasm,Centrosome,Cytosol "Nucleoplasm, Centrosome" Cytosol "HPA030304: AB_10670560" "unprognostic (4.75e-3)" "unprognostic (4.30e-2)" "unprognostic (2.44e-2)" "unprognostic (7.69e-2)" "unprognostic (1.84e-1)" "unprognostic (4.53e-2)" "unprognostic (2.02e-2)" "unprognostic (1.55e-1)" "unprognostic (1.33e-1)" "unprognostic (1.10e-1)" "unprognostic (1.59e-2)" "unprognostic (2.80e-1)" "unprognostic (1.37e-1)" "unprognostic (9.26e-3)" "unprognostic (1.91e-1)" "unprognostic (1.30e-1)" "unprognostic (1.69e-2)" 15.2 8.2 4.7 7.0 6.8 3.0 8.0 6.7 7.3 6.0 6.7 5.9 6.9 10.1 5.3 8.4 13.9 5.4 5.2 3.5 3.7 2.8 7.4 7.4 3.5 7.2 3.7 3.6 5.6 9.0 3.3 4.5 4.7 3.5 6.9 2.7 6.9 8.0 5.7 5.3 12.5 8.5 4.8 4.7 9.0 8.2 40.7 3.4 6.2 8.5 6.6 10.1 6.5 7.6 6.1 1.4 1.2 1.6 2.9 6.3 2.3 9.4 6.7 0.5 4.0 0.7 0.6 2.4 1.2 0.8 1.4 1.3 4.3 6.0 8.4 4.0 0.3 17.7 0.7 2.6 0.3 5.3 6.0 0.5 1.9 2.1 1.6 0.7 0.0 1.2 5.1 1.2 2.1 1.0 0.0 2.6 0.6 4.2 3.2 3.5 2.2 27.2 5.6 1.6 3.7 0.6 1.6 4.9 2.5 4.1 9.3 3.6 6.0 0.7 1.7 1.6 1.1 3.0 5.3 9.6 5.8 4.1 1.9 3.6 1.2 0.0 1.3 1.2 6.3 1.6 4.1 5.1 3.7 4.9 1.4 6.1 5.3 4.4 0.4 2.9 1.1 1.0 4.0 2.3 4.7 6.8 6.7 7.3 3.7 2.8 3.7 3.6 3.5 3.4 UCHL1 "PARK5, PGP9.5, Uch-L1" ENSG00000154277 "Ubiquitin C-terminal hydrolase L1" P09936 4 41256413-41268455 "Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Disease mutation, Hereditary spastic paraplegia, Neurodegeneration, Parkinson disease, Parkinsonism" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 6 "brain: 225.8" "Cell line enhanced" "Detected in many" "EFO-21: 97.1;SCLC-21H: 96.9;U-251 MG: 88.7;U-266/84: 85.5;U-87 MG: 94.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Cell type enhanced" "Detected in single" "memory B-cell: 3.6" "Lineage enriched" "Detected in single" 37 "B-cells: 3.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB002580, HPA005993, CAB079024" Enhanced Supported Supported Nucleoplasm,Cytosol 440000 Cytosol Nucleoplasm "CAB002580: AB_563981, CAB079024: , HPA005993: AB_1858560" "unprognostic (1.54e-1)" "unprognostic (1.96e-1)" "unprognostic (1.12e-1)" "prognostic unfavourable (4.08e-5)" "unprognostic (2.34e-1)" "unprognostic (1.98e-1)" "unprognostic (6.28e-3)" "unprognostic (1.09e-2)" "unprognostic (4.31e-2)" "unprognostic (8.77e-3)" "unprognostic (3.56e-3)" "unprognostic (3.70e-2)" "unprognostic (1.82e-3)" "unprognostic (1.24e-2)" "unprognostic (7.12e-3)" "unprognostic (2.10e-2)" "prognostic unfavourable (1.93e-4)" 8.2 40.2 52.4 8.9 65.1 2.0 3.1 17.5 225.8 4.5 6.3 11.5 0.0 5.5 6.0 1.8 2.7 5.7 6.5 5.4 53.4 97.4 14.0 2.0 2.7 6.5 62.0 57.1 15.4 6.3 1.8 30.5 2.7 100.6 5.3 4.7 6.0 3.0 4.4 7.5 2.7 8.6 5.2 38.6 2.3 2.8 8.0 8.3 0.0 3.9 0.0 4.5 5.6 2.8 3.6 0.0 0.0 0.0 0.0 0.0 0.6 0.2 55.0 11.4 0.0 1.5 1.9 0.0 57.6 29.7 20.4 20.6 11.1 0.0 0.0 97.1 29.3 0.1 21.0 0.0 8.3 0.1 8.6 0.0 0.3 0.0 44.0 0.0 0.0 10.6 0.2 16.3 0.0 0.1 0.0 0.2 10.8 0.0 0.0 0.9 32.9 62.2 0.0 24.4 0.0 30.8 0.0 96.9 60.9 0.3 0.2 0.1 0.0 0.4 0.3 1.3 0.4 0.0 88.7 45.5 85.5 0.2 94.2 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 3.6 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 52.4 65.1 17.5 92.6 53.4 97.4 62.0 57.1 100.6 8.3 UCHL3 ENSG00000118939 "Ubiquitin C-terminal hydrolase L3" P15374 13 75549480-75606020 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA019678, CAB037139, CAB037208" Approved Supported Nucleoplasm,Cytosol 490000 "Nucleoplasm, Cytosol" "CAB037139: AB_1841234, CAB037208: AB_1841235, HPA019678: AB_1858583" "unprognostic (4.16e-1)" "unprognostic (3.84e-2)" "unprognostic (8.83e-3)" "unprognostic (1.14e-1)" "unprognostic (5.15e-2)" "unprognostic (6.46e-3)" "prognostic unfavourable (6.41e-4)" "unprognostic (1.19e-1)" "unprognostic (5.59e-2)" "unprognostic (9.71e-2)" "unprognostic (1.24e-1)" "unprognostic (7.09e-2)" "unprognostic (4.47e-2)" "unprognostic (3.97e-1)" "unprognostic (2.76e-2)" "unprognostic (8.84e-2)" "unprognostic (3.26e-2)" 13.7 39.1 23.6 11.9 37.6 17.4 21.4 17.5 18.7 10.6 21.2 11.4 12.8 12.8 9.0 40.5 37.7 8.1 12.4 15.5 20.6 12.6 20.7 36.8 10.3 12.2 18.2 13.5 7.7 20.8 9.5 28.9 26.3 14.7 12.4 25.0 6.1 24.0 14.9 31.7 28.8 15.0 16.9 13.3 15.3 14.5 24.6 18.6 18.9 28.1 29.8 20.2 16.0 16.2 17.4 46.0 15.8 43.5 20.5 23.4 17.3 53.2 8.9 7.8 5.4 14.6 17.4 22.5 20.2 20.0 26.3 29.5 49.3 25.9 27.6 14.6 21.2 29.4 18.2 49.0 40.0 14.7 15.9 17.4 14.8 31.5 21.1 41.5 13.1 15.5 34.1 20.5 33.1 25.6 19.0 7.9 39.5 19.2 16.8 27.2 11.6 26.9 13.5 12.6 18.1 30.9 21.7 23.5 6.9 11.5 22.4 9.3 12.9 11.8 19.8 11.5 13.7 12.2 26.9 11.1 12.3 32.1 23.2 45.0 8.2 15.6 24.1 15.8 10.9 43.5 14.2 17.4 19.9 15.5 33.6 16.0 19.8 18.3 5.4 20.5 36.2 46.0 23.4 17.3 23.6 37.6 17.5 18.7 20.6 12.6 18.2 13.5 14.7 18.6 UCHL5 "CGI-70, INO80R, UCH37" ENSG00000116750 "Ubiquitin C-terminal hydrolase L5" Q9Y5K5 1 193012250-193060080 "Enzymes, Plasma proteins, Predicted intracellular proteins" "DNA damage, DNA recombination, DNA repair, Transcription, Transcription regulation, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA005908, HPA075383" Approved Supported Nucleoplasm,Mitochondria "Nucleoplasm, Mitochondria" "HPA005908: AB_1858585, HPA075383: " "unprognostic (3.66e-2)" "unprognostic (3.84e-3)" "unprognostic (5.17e-2)" "unprognostic (5.98e-2)" "unprognostic (1.20e-2)" "unprognostic (1.20e-1)" "unprognostic (3.50e-2)" "unprognostic (7.41e-2)" "unprognostic (1.96e-2)" "unprognostic (1.04e-3)" "unprognostic (3.44e-3)" "unprognostic (6.92e-2)" "unprognostic (6.41e-3)" "unprognostic (1.51e-1)" "unprognostic (7.15e-2)" "prognostic unfavourable (7.10e-5)" "unprognostic (4.33e-2)" 15.7 18.3 20.1 16.1 26.2 16.0 18.2 30.1 34.8 10.9 17.7 11.5 12.6 19.0 12.5 14.7 26.1 10.7 11.9 22.0 21.6 20.6 21.6 28.3 12.4 19.9 21.3 29.4 13.4 24.8 15.6 16.2 17.8 33.3 17.8 18.8 10.3 19.3 12.9 29.1 16.7 18.0 13.9 20.1 17.3 14.0 9.9 17.5 20.0 15.1 19.1 23.0 14.8 14.8 22.5 20.8 23.8 21.1 35.6 30.9 20.9 33.2 18.5 16.0 16.4 9.3 9.5 19.1 19.6 10.0 18.8 16.3 17.4 22.6 26.1 18.9 10.8 20.7 21.3 25.3 24.9 26.9 15.3 30.9 23.9 23.1 15.0 48.5 17.4 8.7 11.3 26.9 23.9 18.5 67.7 21.3 15.9 26.8 35.7 18.0 14.8 11.7 20.7 18.0 50.7 17.5 19.5 16.3 20.1 17.6 25.5 27.2 20.7 24.5 12.0 17.6 5.4 17.8 31.1 16.6 25.6 29.4 10.5 30.3 29.9 23.8 16.5 19.0 28.3 19.5 30.9 22.5 25.9 26.9 19.4 18.0 28.2 30.5 10.0 35.6 21.1 20.8 24.8 20.9 20.1 26.2 30.1 34.8 21.6 20.6 21.3 29.4 33.3 17.5 UFSP1 UFSP ENSG00000176125 "UFM1 specific peptidase 1 (inactive)" Q6NVU6 7 100888723-100889718 "Enzymes, Predicted intracellular proteins" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in all" HPA027099 Uncertain "HPA027099: AB_2214069" "unprognostic (8.56e-2)" "unprognostic (2.62e-2)" "unprognostic (2.23e-1)" "unprognostic (1.94e-1)" "unprognostic (7.21e-3)" "unprognostic (1.18e-1)" "unprognostic (2.62e-1)" "unprognostic (1.51e-2)" "unprognostic (2.14e-1)" "unprognostic (2.11e-1)" "unprognostic (3.55e-3)" "unprognostic (5.71e-2)" "unprognostic (4.40e-2)" "unprognostic (1.77e-1)" "unprognostic (2.48e-1)" "unprognostic (2.46e-1)" "unprognostic (3.09e-2)" 7.4 6.3 2.8 3.9 5.4 2.6 4.0 3.1 4.1 3.1 4.5 6.1 2.8 4.3 5.6 6.1 4.1 4.6 2.5 3.6 4.8 4.6 5.3 6.5 2.8 5.9 8.9 4.1 5.8 8.6 3.4 6.8 5.7 3.9 4.8 2.8 3.0 6.4 5.0 10.6 3.4 5.8 4.0 3.5 4.3 5.1 2.0 7.8 6.5 4.2 2.8 5.0 4.8 4.7 5.9 7.2 2.4 3.9 4.4 6.4 3.1 3.6 4.7 1.1 4.8 4.8 2.8 3.0 2.8 0.9 1.2 0.8 1.9 2.6 0.8 2.2 2.2 7.0 1.4 1.7 0.7 3.2 10.5 3.0 3.8 2.2 4.7 1.3 1.5 3.2 2.1 1.5 6.0 0.3 4.5 2.3 1.8 9.0 3.0 7.4 3.6 6.5 1.5 1.4 6.9 2.1 1.5 3.4 5.5 5.5 7.2 3.0 1.7 1.1 1.2 3.2 3.2 3.4 2.2 2.3 2.7 0.2 1.1 2.3 3.6 0.0 3.9 2.4 5.4 3.4 6.1 1.8 4.7 2.9 4.8 5.9 5.3 6.4 0.8 4.4 3.3 7.2 2.0 3.1 2.8 5.4 3.1 4.1 4.8 4.6 8.9 4.1 3.9 7.8 UFSP2 "C4orf20, FLJ11200" ENSG00000109775 "UFM1 specific peptidase 2" Q9NUQ7 4 185399540-185425985 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Disease mutation, Dwarfism" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA039985, HPA043298" Approved Approved Nucleoplasm,Cytosol "Nucleoplasm, Cytosol" "HPA039985: AB_10794206, HPA043298: AB_10795037" "unprognostic (8.87e-2)" "unprognostic (1.85e-2)" "unprognostic (1.52e-1)" "unprognostic (1.97e-1)" "unprognostic (1.17e-1)" "unprognostic (1.29e-1)" "unprognostic (3.63e-2)" "unprognostic (3.19e-2)" "unprognostic (3.69e-1)" "unprognostic (1.50e-1)" "unprognostic (2.04e-2)" "unprognostic (2.56e-1)" "prognostic favourable (1.07e-8)" "unprognostic (1.92e-1)" "unprognostic (8.12e-2)" "unprognostic (9.36e-3)" "unprognostic (6.70e-3)" 15.8 20.3 12.5 10.3 14.9 4.1 18.7 11.3 20.3 17.3 17.4 16.3 17.0 11.0 19.4 17.4 20.1 17.3 13.5 24.2 11.4 11.7 28.1 19.2 13.2 11.6 14.6 11.3 30.5 20.1 18.3 22.8 12.3 17.0 18.4 12.6 13.7 14.4 20.3 40.8 16.6 13.6 16.9 20.2 14.2 17.3 23.7 14.6 15.8 23.5 19.2 12.2 20.8 13.3 15.6 13.0 5.5 7.9 13.9 17.9 8.2 12.0 7.4 20.8 15.0 18.8 19.6 11.5 12.5 12.7 15.0 14.2 12.4 15.5 12.2 5.8 15.1 9.6 16.1 20.3 15.6 13.0 9.4 6.4 7.2 11.2 20.8 9.7 8.0 11.5 15.9 13.1 13.6 24.0 16.3 24.6 19.4 7.3 13.0 7.3 5.4 10.7 12.9 8.2 14.6 14.4 7.0 12.4 11.6 7.8 12.7 15.2 9.8 6.9 13.9 6.3 11.1 4.3 9.7 22.4 8.6 5.8 20.3 6.1 15.9 5.5 7.9 5.4 16.3 6.8 17.1 15.6 16.5 17.6 9.8 11.0 17.8 17.9 0.4 13.9 6.6 13.0 14.0 8.2 12.5 14.9 11.3 20.3 11.4 11.7 14.6 11.3 17.0 14.6 UQCRC1 "D3S3191, QCR1, UQCR1" ENSG00000010256 "Ubiquinol-cytochrome c reductase core protein 1" P31930 3 48599002-48610976 "Enzymes, Predicted intracellular proteins" "Electron transport, Respiratory chain, Transport" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 172.7" "Cell line enhanced" "Detected in all" "PC-3: 64.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA002815, HPA003525, CAB033782" Enhanced Supported Mitochondria,Cytosol 1300000 Mitochondria Cytosol "CAB033782: AB_2213631, HPA002815: AB_1080486, HPA003525: AB_1080484" "unprognostic (1.29e-1)" "unprognostic (3.15e-3)" "unprognostic (6.91e-3)" "unprognostic (1.06e-1)" "unprognostic (1.66e-1)" "unprognostic (9.91e-2)" "unprognostic (8.53e-2)" "unprognostic (1.99e-1)" "unprognostic (3.11e-2)" "unprognostic (9.14e-2)" "unprognostic (3.37e-1)" "unprognostic (7.20e-2)" "prognostic favourable (2.35e-10)" "unprognostic (5.37e-2)" "unprognostic (2.35e-1)" "unprognostic (1.02e-1)" "unprognostic (6.72e-2)" 18.1 13.7 11.1 9.8 12.5 9.4 11.8 12.5 20.5 11.0 33.7 6.9 10.4 20.0 9.1 9.7 15.8 12.4 10.8 66.7 10.8 11.2 23.0 30.5 7.7 9.3 13.3 13.5 6.3 14.4 20.4 7.8 11.5 13.3 12.5 12.3 7.8 19.5 21.9 172.7 14.0 20.9 12.0 8.7 8.4 23.0 18.4 7.4 9.4 9.1 39.9 9.8 10.3 9.1 23.3 52.7 28.1 57.8 15.1 22.0 74.3 10.0 16.2 5.9 3.6 8.7 8.0 26.7 18.5 15.0 15.4 14.0 25.2 3.0 25.9 11.7 8.3 9.7 7.4 21.5 2.8 15.4 35.5 26.6 14.1 27.4 17.3 16.7 11.5 11.0 24.4 10.5 17.2 15.2 14.3 1.7 9.3 17.4 12.0 19.1 14.8 64.6 8.2 15.7 21.2 15.9 11.0 6.3 11.2 25.1 3.0 14.8 6.4 2.6 15.3 4.3 16.3 13.4 19.1 15.8 13.9 15.0 9.4 19.3 13.7 17.6 57.8 28.1 18.9 56.9 17.9 23.3 18.9 19.0 52.7 18.6 17.1 16.4 14.1 15.1 48.5 21.0 22.0 74.3 11.1 12.5 12.5 20.5 10.8 11.2 13.3 13.5 13.3 7.4 UQCRC2 "QCR2, UQCR2" ENSG00000140740 "Ubiquinol-cytochrome c reductase core protein 2" P22695 16 21952660-21983660 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" "Electron transport, Respiratory chain, Transport" "Disease mutation, Primary mitochondrial disease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA007998, HPA019146" Enhanced Enhanced Mitochondria 4000000 Mitochondria "HPA007998: AB_1858648, HPA019146: AB_1858649" "unprognostic (1.33e-1)" "unprognostic (1.32e-1)" "unprognostic (1.49e-3)" "unprognostic (3.35e-1)" "unprognostic (1.26e-2)" "unprognostic (6.91e-2)" "unprognostic (2.71e-2)" "unprognostic (1.32e-1)" "unprognostic (1.72e-1)" "unprognostic (8.87e-2)" "unprognostic (1.67e-2)" "unprognostic (2.43e-2)" "prognostic favourable (6.58e-9)" "unprognostic (2.33e-1)" "unprognostic (9.78e-3)" "unprognostic (4.67e-3)" "unprognostic (7.36e-2)" 22.7 26.8 20.6 17.1 32.7 20.5 21.3 29.2 33.7 17.7 38.4 17.4 19.5 45.0 20.8 18.6 28.7 20.0 19.1 94.9 19.8 19.3 35.1 35.8 15.9 23.6 20.9 28.5 21.9 20.8 36.6 20.2 17.8 29.6 17.7 40.5 18.5 22.1 20.2 103.9 22.2 42.0 30.4 16.5 16.5 29.3 10.3 19.2 25.2 21.4 70.0 22.9 27.9 20.0 20.0 30.6 14.3 29.3 18.7 25.7 27.4 18.9 20.9 12.9 8.6 14.4 20.2 18.3 18.4 15.0 16.9 17.2 33.7 18.8 37.7 16.6 15.8 34.7 20.9 18.5 19.5 17.2 19.4 21.3 18.4 47.6 15.3 27.1 54.0 23.6 23.2 13.2 18.2 22.1 23.0 19.7 18.3 25.2 28.1 17.6 14.1 16.1 32.9 29.9 41.2 25.3 22.4 17.8 13.0 26.1 33.0 19.8 37.8 28.8 19.5 12.0 11.3 11.7 16.4 14.3 10.3 33.4 19.6 28.8 13.7 14.3 24.7 12.8 16.9 29.3 21.9 20.0 20.5 18.6 30.6 15.8 22.8 20.8 9.1 18.7 27.6 13.2 25.7 27.4 20.6 32.7 29.2 33.7 19.8 19.3 20.9 28.5 29.6 19.2 USP1 ENSG00000162607 "Ubiquitin specific peptidase 1" O94782 1 62436297-62451804 "Enzymes, Plasma proteins, Predicted intracellular proteins" "DNA damage, DNA repair, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "lymphoid tissue: 70.6" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA028387, HPA028440" Approved Supported Nucleoplasm Nucleoplasm "HPA028387: , HPA028440: AB_10603000" "unprognostic (1.22e-1)" "unprognostic (5.36e-2)" "unprognostic (1.78e-3)" "unprognostic (4.05e-3)" "unprognostic (2.57e-1)" "unprognostic (1.72e-2)" "prognostic unfavourable (5.81e-5)" "unprognostic (6.72e-2)" "unprognostic (1.11e-2)" "unprognostic (5.32e-2)" "unprognostic (3.33e-3)" "unprognostic (3.99e-2)" "unprognostic (2.76e-2)" "unprognostic (9.61e-3)" "unprognostic (5.70e-2)" "unprognostic (1.96e-1)" "unprognostic (1.71e-1)" 11.6 9.0 11.3 17.2 10.7 29.3 15.9 20.6 14.2 19.2 13.3 7.8 8.0 10.8 15.1 12.0 15.6 13.8 8.9 9.0 11.5 9.6 11.8 9.3 11.7 19.2 14.2 9.6 26.7 12.7 14.8 18.4 13.6 10.9 14.8 13.9 7.6 12.7 13.5 11.7 12.3 13.3 15.8 15.5 18.1 11.6 31.6 11.8 70.6 15.0 13.3 20.1 16.5 16.5 14.7 11.8 23.4 12.4 15.5 16.3 9.2 22.0 6.5 27.4 14.8 6.2 7.4 15.2 21.2 14.5 26.4 29.0 11.0 10.8 39.9 15.4 11.9 12.8 22.5 14.6 37.0 19.9 16.2 32.7 22.6 11.5 6.7 35.0 16.5 3.9 9.6 23.9 18.0 12.4 23.7 34.9 18.6 9.8 35.9 13.5 24.1 13.5 34.1 46.5 24.7 9.9 16.5 28.4 15.9 24.0 19.6 23.2 11.2 21.4 8.6 20.4 22.2 29.8 29.7 13.9 19.3 45.8 13.8 28.0 18.2 17.4 9.5 23.4 12.6 9.6 16.3 14.7 15.0 12.7 11.4 10.7 14.3 11.9 16.9 15.5 12.4 11.8 13.6 9.2 11.3 10.7 20.6 14.2 11.5 9.6 14.2 9.6 10.9 11.8 USP10 "KIAA0190, UBPO" ENSG00000103194 "Ubiquitin specific peptidase 10" Q14694 16 84699978-84779922 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Autophagy, DNA damage, DNA repair, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "blood: 105.5" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Cell type enriched" "Detected in all" 6 "neutrophil: 105.5" "Lineage enriched" "Detected in all" 6 "granulocytes: 105.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA006731, HPA006749" Enhanced Enhanced Nucleoplasm,Cytosol Cytosol Nucleoplasm "HPA006731: AB_1080495, HPA006749: AB_1080492" "unprognostic (4.14e-2)" "unprognostic (2.28e-1)" "unprognostic (2.36e-2)" "unprognostic (4.85e-2)" "unprognostic (6.93e-2)" "unprognostic (1.77e-3)" "unprognostic (1.03e-3)" "unprognostic (2.91e-3)" "unprognostic (1.75e-1)" "unprognostic (3.84e-2)" "unprognostic (2.56e-2)" "unprognostic (1.82e-3)" "prognostic favourable (1.00e-4)" "unprognostic (5.91e-2)" "unprognostic (4.57e-2)" "unprognostic (8.57e-2)" "unprognostic (1.38e-1)" 13.9 18.8 16.0 24.2 19.0 13.4 14.4 24.4 20.4 15.9 18.1 15.6 8.4 16.1 20.2 10.4 19.7 18.2 12.0 16.4 19.3 15.1 16.4 20.7 13.7 18.8 19.7 17.4 18.5 17.1 35.8 15.0 23.5 16.2 15.0 15.6 17.9 15.3 17.8 47.0 17.0 17.5 20.2 16.3 16.0 15.0 15.5 16.2 20.4 17.6 15.7 20.9 19.7 15.8 7.2 10.4 105.5 8.6 7.7 17.3 10.0 13.6 18.9 18.4 22.8 6.8 11.6 24.9 13.5 14.3 22.9 12.6 26.6 11.9 23.7 15.7 14.1 15.7 25.5 21.5 30.5 9.6 13.4 13.6 8.9 17.6 9.0 20.2 8.3 7.3 16.6 23.9 27.7 17.5 37.1 5.2 15.8 28.6 20.9 9.8 22.1 12.8 27.2 10.1 11.2 14.4 11.1 17.2 10.1 32.3 10.5 9.1 24.1 12.9 12.8 15.9 12.7 8.0 12.8 8.7 12.1 60.1 10.3 13.0 16.3 2.5 8.6 1.6 5.7 7.0 6.8 7.2 17.3 6.3 10.4 6.7 9.9 6.0 105.5 7.7 6.3 3.5 6.1 10.0 16.0 19.0 24.4 20.4 19.3 15.1 19.7 17.4 16.2 16.2 USP11 UHX1 ENSG00000102226 "Ubiquitin specific peptidase 11" P51784 X 47232690-47248328 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Host-virus interaction, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 74.0" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA003103, HPA037536" Enhanced Supported Supported Nucleoplasm "Intracellular and membrane" Nucleoplasm "HPA003103: AB_10671088, HPA037536: AB_10672904" "unprognostic (1.60e-1)" "unprognostic (2.77e-3)" "unprognostic (5.84e-2)" "prognostic unfavourable (2.95e-4)" "unprognostic (3.08e-2)" "unprognostic (2.02e-1)" "unprognostic (6.11e-3)" "unprognostic (9.21e-2)" "unprognostic (3.18e-2)" "unprognostic (3.52e-1)" "unprognostic (3.29e-3)" "unprognostic (3.74e-2)" "prognostic favourable (4.13e-5)" "unprognostic (3.14e-2)" "unprognostic (9.23e-2)" "unprognostic (9.51e-2)" "unprognostic (7.11e-2)" 11.5 17.3 32.9 11.5 55.0 4.9 9.4 35.7 74.0 17.5 9.1 19.9 5.8 6.0 22.6 12.7 9.7 26.6 12.8 20.6 27.0 44.0 13.6 6.7 12.5 13.8 23.1 47.4 38.2 13.8 28.4 32.3 12.6 27.8 15.7 7.6 17.9 9.3 21.3 13.7 7.8 7.3 19.1 17.0 13.5 9.1 19.2 14.6 19.0 27.2 4.3 14.3 11.0 9.8 21.0 20.6 22.8 8.7 19.8 31.7 16.4 14.3 22.6 38.9 26.5 14.7 9.9 10.8 11.0 17.3 21.9 24.5 21.5 11.8 9.5 8.7 19.8 17.1 31.5 7.7 19.5 14.7 23.9 11.1 17.9 19.1 17.1 12.4 23.2 14.2 3.2 23.1 9.9 8.7 8.3 1.3 17.0 21.8 24.1 13.3 28.9 20.2 27.2 38.1 7.9 10.7 19.8 22.0 37.8 20.1 4.1 11.9 8.5 7.2 9.1 18.5 19.5 26.0 12.5 17.7 11.1 16.6 11.4 15.5 16.4 22.8 3.5 7.4 22.6 7.4 19.9 20.1 10.2 22.1 4.6 21.0 15.4 31.7 2.2 19.8 8.7 20.6 12.7 16.4 32.9 55.0 35.7 74.0 27.0 44.0 23.1 47.4 27.8 14.6 USP12 USP12L1 ENSG00000152484 "Ubiquitin specific peptidase 12" O75317 13 27066142-27171896 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA007288, HPA059492" Uncertain Approved Nucleoplasm Nucleoplasm "HPA007288: AB_1080531, HPA059492: " "unprognostic (6.72e-3)" "unprognostic (2.63e-3)" "unprognostic (1.04e-1)" "unprognostic (2.34e-2)" "unprognostic (1.22e-1)" "unprognostic (5.85e-2)" "unprognostic (1.79e-1)" "unprognostic (3.39e-1)" "unprognostic (8.38e-2)" "unprognostic (8.77e-2)" "unprognostic (2.20e-1)" "unprognostic (3.06e-2)" "unprognostic (1.22e-2)" "unprognostic (1.40e-1)" "unprognostic (2.91e-1)" "unprognostic (6.77e-2)" "unprognostic (1.73e-1)" 15.7 10.4 18.3 23.3 17.8 46.0 15.6 16.6 18.3 12.1 30.6 16.1 8.8 13.0 15.3 11.6 23.5 9.5 14.5 11.3 19.3 15.9 18.3 27.9 19.9 19.6 20.5 7.5 12.0 13.4 10.7 16.2 14.8 12.4 17.5 19.1 10.1 8.9 9.5 9.8 17.3 33.0 43.8 18.5 16.5 14.7 11.0 13.1 8.4 12.0 6.6 18.5 42.8 24.2 4.6 3.0 5.3 2.1 2.3 3.6 1.2 12.0 7.6 14.6 7.5 9.8 12.5 5.2 17.0 12.0 9.5 7.1 13.7 19.0 17.2 8.6 13.4 7.5 9.5 9.9 20.3 27.7 8.2 26.6 9.9 9.6 12.3 15.3 18.7 7.8 14.5 10.7 12.3 21.8 8.8 8.4 19.6 7.0 9.4 20.5 10.4 13.5 10.8 18.6 4.0 18.7 8.6 16.1 9.7 14.6 12.3 13.8 5.8 15.0 25.7 9.9 9.6 21.2 15.4 6.4 7.1 12.3 16.7 9.2 11.0 0.0 1.2 5.3 1.5 1.3 2.5 3.2 2.4 2.0 1.6 4.6 1.6 1.7 1.2 2.3 2.1 3.0 3.6 1.2 18.3 17.8 16.6 15.5 19.3 15.9 20.5 7.5 12.4 13.1 USP13 IsoT-3 ENSG00000058056 "Ubiquitin specific peptidase 13" Q92995 3 179652755-179789401 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Autophagy, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "heart muscle: 34.8;skeletal muscle: 90.3" "Low cell line specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Cell type enriched" "Detected in many" 5 "MAIT T-cell: 15.4" "Lineage enriched" "Detected in many" 8 "T-cells: 15.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA004827 Enhanced Approved Nucleoplasm,Cytosol "Nucleoplasm, Cytosol" "HPA004827: AB_1080497" "unprognostic (1.00e-2)" "unprognostic (2.09e-1)" "unprognostic (5.82e-2)" "unprognostic (7.14e-2)" "unprognostic (9.94e-2)" "unprognostic (3.96e-2)" "prognostic unfavourable (2.40e-5)" "unprognostic (1.76e-1)" "unprognostic (4.55e-2)" "unprognostic (7.79e-2)" "unprognostic (1.69e-3)" "unprognostic (2.22e-2)" "prognostic unfavourable (3.46e-6)" "unprognostic (4.93e-2)" "unprognostic (9.79e-2)" "unprognostic (3.38e-2)" "prognostic unfavourable (3.06e-4)" 6.4 7.5 2.0 2.3 2.8 0.8 3.5 2.9 4.1 2.7 2.1 4.6 1.5 0.7 3.2 3.8 2.6 2.5 2.5 34.8 2.0 2.3 2.3 3.4 6.0 2.5 2.1 2.1 7.2 3.0 3.3 9.8 1.9 3.0 3.0 1.8 3.1 3.3 2.1 90.3 1.8 1.7 3.7 2.5 1.6 1.6 5.6 1.3 1.7 5.5 17.1 3.2 2.6 1.9 2.0 1.9 0.0 0.4 0.0 15.4 0.7 12.3 5.3 10.1 7.7 4.6 6.4 4.9 7.3 8.4 10.8 9.1 7.8 4.4 15.3 8.2 8.8 0.9 11.3 4.4 12.9 36.2 4.8 4.0 8.0 7.3 3.3 11.2 0.0 6.8 1.6 8.4 10.7 8.6 1.9 19.8 8.9 8.1 6.8 2.0 7.8 4.8 11.7 10.0 12.5 7.3 3.5 5.7 7.4 7.0 9.4 4.2 16.2 8.1 9.3 13.0 10.4 11.1 28.1 9.6 8.0 31.4 6.0 7.6 12.1 0.0 0.2 0.0 1.3 0.4 15.4 2.0 1.3 2.9 1.5 0.6 1.0 1.0 0.0 0.0 0.4 1.9 0.6 0.7 2.0 2.8 2.9 4.1 2.0 2.3 2.1 2.1 3.0 1.3 USP14 TGT ENSG00000101557 "Ubiquitin specific peptidase 14" P54578 18 158383-214629 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Immunity, Innate immunity, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA001308 Approved Supported Cytosol 1400000 Cytosol "HPA001308: AB_1080499" "unprognostic (2.21e-1)" "unprognostic (4.05e-2)" "unprognostic (1.90e-1)" "unprognostic (2.59e-3)" "unprognostic (6.04e-2)" "prognostic unfavourable (7.81e-5)" "prognostic unfavourable (4.30e-5)" "unprognostic (5.14e-2)" "unprognostic (5.00e-2)" "prognostic favourable (7.91e-4)" "unprognostic (1.64e-2)" "unprognostic (2.39e-1)" "unprognostic (1.51e-3)" "unprognostic (2.58e-1)" "unprognostic (1.55e-1)" "unprognostic (2.20e-2)" "unprognostic (3.76e-2)" 24.8 24.2 25.9 20.7 32.1 19.4 21.7 21.7 28.4 16.5 17.1 17.9 19.1 13.4 19.4 24.3 25.3 14.7 14.4 23.3 22.1 27.6 23.2 24.4 15.8 21.9 22.6 28.8 16.2 16.2 22.3 18.0 25.1 29.2 29.9 19.4 14.5 16.7 20.5 53.3 15.7 12.9 23.9 22.1 15.4 15.6 17.2 16.5 19.5 20.1 25.4 28.6 17.8 17.8 13.1 15.2 7.7 15.2 23.0 21.2 11.0 26.8 22.1 18.8 19.1 18.7 18.7 33.7 35.3 19.4 36.0 33.6 28.7 14.4 39.9 27.0 28.9 15.1 37.1 27.0 41.1 11.3 18.3 22.5 14.8 22.5 18.7 55.2 21.6 14.9 20.9 36.7 21.1 27.6 31.0 29.7 35.4 21.8 30.8 15.1 18.4 26.0 25.7 24.7 29.1 26.6 23.3 22.0 18.5 36.6 17.7 15.0 17.3 14.9 31.2 42.3 32.0 38.8 50.0 19.6 35.6 39.7 24.4 23.0 26.3 5.0 10.7 7.7 17.8 15.2 21.2 13.1 17.7 18.4 15.2 10.1 17.5 16.9 0.8 23.0 11.4 11.1 16.7 11.0 25.9 32.1 21.7 27.1 22.1 27.6 22.6 28.8 29.2 16.5 USP15 "KIAA0529, UNPH4" ENSG00000135655 "Ubiquitin specific peptidase 15" Q9Y4E8 12 62260338-62417431 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Host-virus interaction, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 88.9" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Cell type enhanced" "Detected in all" "neutrophil: 68.5" "Lineage enriched" "Detected in all" 5 "granulocytes: 68.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA006237, HPA006428, HPA071014" Approved Enhanced Cytosol 280000 Cytosol "HPA006237: AB_1080502, HPA006428: , HPA071014: " "unprognostic (8.18e-2)" "unprognostic (3.22e-1)" "unprognostic (9.63e-2)" "unprognostic (2.09e-1)" "unprognostic (1.10e-1)" "unprognostic (2.75e-1)" "prognostic unfavourable (8.04e-4)" "unprognostic (6.59e-2)" "unprognostic (7.70e-3)" "unprognostic (2.19e-1)" "unprognostic (2.47e-1)" "unprognostic (4.51e-2)" "prognostic unfavourable (1.58e-5)" "unprognostic (9.28e-2)" "unprognostic (5.81e-3)" "unprognostic (1.11e-2)" "unprognostic (1.26e-1)" 23.1 16.8 11.5 22.5 11.9 88.9 17.8 21.1 15.7 14.5 14.5 5.2 11.9 11.4 12.7 12.4 16.1 14.1 11.2 15.2 9.6 6.2 13.8 20.4 23.8 26.2 11.6 9.4 22.5 15.8 18.9 22.5 31.0 14.9 12.4 13.8 7.6 16.2 10.7 28.5 23.0 19.7 16.3 16.2 35.6 14.3 20.0 11.0 33.1 14.1 15.4 18.9 18.4 17.9 5.7 6.0 68.5 14.2 3.3 12.1 4.8 9.3 8.8 8.8 7.6 13.9 16.3 15.7 15.2 13.5 13.5 12.1 8.8 9.4 10.0 8.7 13.0 10.2 11.7 13.2 15.8 11.0 7.2 13.7 7.5 6.7 13.5 21.7 33.4 11.8 13.8 15.9 14.2 15.9 44.4 19.4 12.4 10.4 12.9 11.0 12.9 13.0 8.3 9.3 16.1 12.5 10.8 11.1 5.3 17.6 11.2 8.6 14.7 13.0 19.0 10.5 10.5 16.3 9.4 9.2 10.2 11.4 12.0 17.7 11.8 27.2 14.2 13.8 3.4 7.3 3.5 5.7 4.6 3.2 4.9 4.7 5.9 3.5 68.5 3.3 5.8 6.0 12.1 4.8 11.5 11.9 21.1 15.7 9.6 6.2 11.6 9.4 14.9 11.0 USP16 Ubp-M ENSG00000156256 "Ubiquitin specific peptidase 16" Q9Y5T5 21 29024629-29054488 "Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Cell cycle, Cell division, Mitosis, Transcription, Transcription regulation, Ubl conjugation pathway" "Activator, Chromatin regulator, Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA021140 Supported Approved Nucleoplasm,Cytosol "Nucleoplasm, Cytosol" "HPA021140: AB_1858668" "unprognostic (6.06e-2)" "unprognostic (3.14e-1)" "unprognostic (1.10e-2)" "unprognostic (1.47e-1)" "unprognostic (5.92e-2)" "unprognostic (5.79e-3)" "unprognostic (1.92e-1)" "unprognostic (8.99e-2)" "unprognostic (5.78e-2)" "unprognostic (7.40e-2)" "unprognostic (8.73e-2)" "unprognostic (8.65e-2)" "unprognostic (6.68e-2)" "unprognostic (2.84e-1)" "unprognostic (1.55e-1)" "unprognostic (2.84e-2)" "unprognostic (1.54e-1)" 25.4 21.7 24.4 27.4 24.2 20.4 22.8 32.4 23.1 24.2 24.3 13.5 23.6 20.4 22.6 28.2 27.1 19.4 17.0 23.8 23.8 22.6 28.4 34.0 16.8 20.7 25.8 19.5 27.3 23.6 31.6 41.6 45.9 25.3 26.0 22.3 13.3 20.6 28.8 35.8 16.1 33.2 26.2 28.6 29.1 20.8 20.1 25.3 37.6 28.4 25.6 25.5 30.8 17.1 30.9 23.5 21.2 20.5 19.9 26.2 10.1 21.8 8.7 13.9 12.5 9.9 16.3 13.1 21.3 14.2 14.8 14.1 10.9 14.2 22.3 6.5 20.4 10.0 17.2 15.5 19.4 21.3 18.3 29.7 10.6 12.1 14.7 29.1 16.5 13.9 16.4 19.3 17.8 14.2 24.4 39.4 17.1 10.0 17.9 10.6 14.8 11.3 12.0 34.3 25.5 12.2 15.8 15.1 16.1 13.8 22.1 18.7 15.2 20.0 14.2 17.3 21.6 15.9 21.9 33.7 46.2 23.4 18.1 21.2 17.2 21.2 16.2 20.9 25.4 16.1 19.8 26.4 23.9 22.8 14.9 30.9 26.2 24.8 15.5 19.9 20.5 23.5 24.5 10.1 24.4 24.2 32.4 23.1 23.8 22.6 25.8 19.5 25.3 25.3 USP17L1 USP17L1P ENSG00000230549 "Ubiquitin specific peptidase 17-like family member 1" Q7RTZ2 8 7332387-7333979 "Enzymes, Predicted intracellular proteins" "Apoptosis, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at transcript level" "Evidence at transcript level" "No human protein/transcript evidence" "No human protein/transcript evidence" "Tissue enhanced" "Detected in single" "brain: 2.1" "Cell line enhanced" "Detected in single" "AN3-CA: 1.2" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain "HPA045642: " 0.0 0.0 0.0 0.0 0.0 2.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.2 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L10 ENSG00000231396 "Ubiquitin specific peptidase 17-like family member 10" C9JJH3 4 9210657-9212608 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "No human protein/transcript evidence" "No human protein/transcript evidence" "No human protein/transcript evidence" "No human protein/transcript evidence" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain "HPA045642: " 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L11 ENSG00000233136 "Ubiquitin specific peptidase 17-like family member 11" C9JVI0 4 9215405-9217356 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at transcript level" "Evidence at transcript level" "No human protein/transcript evidence" "No human protein/transcript evidence" "Tissue enhanced" "Detected in some" "blood: 1.0;fallopian tube: 1.2;thyroid gland: 1.3" "Cell line enhanced" "Detected in some" "CAPAN-2: 2.5;NTERA-2: 1.6" "Not detected" "Not detected" "Cell type enriched" "Detected in single" 11 "plasmacytoid DC: 1.0" "Lineage enriched" "Detected in single" 11 "dendritic cells: 1.0" HPA045642 Uncertain "HPA045642: " 0.0 0.0 0.0 0.0 0.3 0.0 0.3 0.0 0.6 0.0 0.0 0.0 0.1 0.0 0.0 1.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 1.3 0.0 0.2 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.5 0.3 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.5 0.0 0.0 1.6 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 USP17L12 ENSG00000227551 "Ubiquitin specific peptidase 17-like family member 12" C9JPN9 4 9220152-9221744 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "No human protein/transcript evidence" "No human protein/transcript evidence" "No human protein/transcript evidence" "No human protein/transcript evidence" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain "HPA045642: " 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L13 ENSG00000232399 "Ubiquitin specific peptidase 17-like family member 13" C9JLJ4 4 9224896-9226847 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "No human protein/transcript evidence" "No human protein/transcript evidence" "No human protein/transcript evidence" "No human protein/transcript evidence" "Not detected" "Not detected" "Cell line enhanced" "Detected in single" "NTERA-2: 1.2" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain "HPA045642: " 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.1 0.2 0.0 0.0 0.2 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L15 ENSG00000223569 "Ubiquitin specific peptidase 17-like family member 15" C9J2P7 4 9234385-9236334 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at transcript level" "Evidence at transcript level" "No human protein/transcript evidence" "No human protein/transcript evidence" "Tissue enhanced" "Detected in some" "brain: 1.0;epididymis: 1.0" "Cell line enhanced" "Detected in single" "U-87 MG: 1.2" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain "HPA045642: " 0.0 0.0 0.3 0.0 0.7 0.0 0.0 0.0 1.0 0.1 0.0 0.0 0.2 1.0 0.0 0.3 0.0 0.1 0.3 0.4 0.0 0.4 0.2 0.0 0.2 0.0 0.0 0.4 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.1 0.0 0.1 0.0 0.1 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.2 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.8 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.9 0.0 0.0 0.0 0.0 0.5 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.3 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L17 ENSG00000249104 "Ubiquitin specific peptidase 17-like family member 17" D6RBQ6 4 9243879-9245830 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at transcript level" "Evidence at transcript level" "No human protein/transcript evidence" "No human protein/transcript evidence" "Tissue enhanced" "Detected in single" "thyroid gland: 1.0" "Cell line enhanced" "Detected in some" "HDLM-2: 1.2;NTERA-2: 1.3" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain "HPA045642: " 0.0 0.0 0.0 0.0 0.2 0.0 0.3 0.0 0.1 0.4 0.0 0.0 0.4 0.0 0.0 0.3 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 1.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L18 ENSG00000250844 "Ubiquitin specific peptidase 17-like family member 18" D6R9N7 4 9248630-9250581 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "No human protein/transcript evidence" "No human protein/transcript evidence" "No human protein/transcript evidence" "No human protein/transcript evidence" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain "HPA045642: " 0.0 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.2 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L19 ENSG00000248920 "Ubiquitin specific peptidase 17-like family member 19" D6RCP7 4 9253378-9255329 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "No human protein/transcript evidence" "No human protein/transcript evidence" "No human protein/transcript evidence" "No human protein/transcript evidence" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain "HPA045642: " 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L2 DUB3 ENSG00000223443 "Ubiquitin specific peptidase 17-like family member 2" Q6R6M4 8 12137168-12139077 "Enzymes, Predicted intracellular proteins" "Apoptosis, Cell cycle, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in some" "Cell line enhanced" "Detected in single" "HEK 293: 1.3" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain "HPA045642: " "unprognostic (2.01e-1)" 0.1 0.4 0.1 0.1 0.5 0.0 0.2 0.8 0.3 0.1 0.1 0.1 0.1 0.0 0.3 0.3 0.1 0.3 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.3 0.1 0.1 1.0 1.1 0.0 0.3 0.1 0.1 0.4 0.0 0.1 0.1 0.1 0.1 0.6 0.1 0.1 0.1 0.2 0.0 0.5 0.1 0.1 0.2 0.1 0.1 0.3 0.2 0.1 0.0 0.0 0.0 0.0 0.5 0.0 0.1 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 1.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.6 0.5 0.3 0.0 0.0 0.0 0.1 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.2 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.5 0.8 0.1 0.1 0.0 0.1 0.1 0.1 0.1 USP17L20 ENSG00000250745 "Ubiquitin specific peptidase 17-like family member 20" D6RJB6 4 9258124-9260075 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "No human protein/transcript evidence" "No human protein/transcript evidence" "No human protein/transcript evidence" "No human protein/transcript evidence" "Not detected" "Not detected" "Cell line enhanced" "Detected in single" "hTERT-HME1: 1.2" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain "HPA045642: " 0.0 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.2 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.6 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L21 ENSG00000249811 "Ubiquitin specific peptidase 17-like family member 21" D6R901 4 9262872-9264823 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "No human protein/transcript evidence" "No human protein/transcript evidence" "No human protein/transcript evidence" "No human protein/transcript evidence" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain "HPA045642: " 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L22 ENSG00000248933 "Ubiquitin specific peptidase 17-like family member 22" D6RA61 4 9267619-9269570 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "No human protein/transcript evidence" "No human protein/transcript evidence" "No human protein/transcript evidence" "No human protein/transcript evidence" "Not detected" "Not detected" "Cell line enhanced" "Detected in single" "BEWO: 1.0" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain "HPA045642: " 0.0 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.2 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.4 0.5 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 USP17L23 ENSG00000250913 "Ubiquitin specific peptidase 17-like family member 23" D6RBM5 4 9272364-9272914 "Enzymes, Predicted intracellular proteins" "Evidence at transcript level" "Evidence at transcript level" "Tissue enhanced" "Detected in single" "gallbladder: 1.0" "Cell line enriched" "Detected in single" 12 "HMC-1: 1.4" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" 0.0 0.0 0.2 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.4 USP17L24 ENSG00000232264 "Ubiquitin specific peptidase 17-like family member 24" Q0WX57 4 9325165-9327116 "Enzymes, Predicted intracellular proteins" "Apoptosis, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "No human protein/transcript evidence" "Evidence at protein level" "Evidence at protein level" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain "HPA045642: " 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L25 ENSG00000230430 "Ubiquitin specific peptidase 17-like family member 25" Q0WX57 4 9329911-9331862 "Enzymes, Predicted intracellular proteins" "Apoptosis, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "No human protein/transcript evidence" "Evidence at protein level" "Evidence at protein level" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain "HPA045642: " 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L26 ENSG00000229579 "Ubiquitin specific peptidase 17-like family member 26" Q0WX57 4 9334658-9336609 "Enzymes, Predicted intracellular proteins" "Apoptosis, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "No human protein/transcript evidence" "Evidence at protein level" "Evidence at protein level" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain "HPA045642: " 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L27 ENSG00000235780 "Ubiquitin specific peptidase 17-like family member 27" Q0WX57 4 9344148-9345740 "Enzymes, Predicted intracellular proteins" "Apoptosis, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "No human protein/transcript evidence" "Evidence at protein level" "Evidence at protein level" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain "HPA045642: " 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L28 ENSG00000231051 "Ubiquitin specific peptidase 17-like family member 28" Q0WX57 4 9348893-9350485 "Enzymes, Predicted intracellular proteins" "Apoptosis, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "No human protein/transcript evidence" "Evidence at protein level" "Evidence at protein level" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain "HPA045642: " 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L29 ENSG00000231637 "Ubiquitin specific peptidase 17-like family member 29" Q0WX57 4 9353638-9355230 "Enzymes, Predicted intracellular proteins" "Apoptosis, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "No human protein/transcript evidence" "Evidence at protein level" "Evidence at protein level" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain "HPA045642: " 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L3 "USP17B, USP17F" ENSG00000225327 "Ubiquitin specific peptidase 17-like family member 3" A6NCW0 8 7976393-7977985 "Enzymes, Predicted intracellular proteins" "Apoptosis, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "No human protein/transcript evidence" "No human protein/transcript evidence" "No human protein/transcript evidence" "No human protein/transcript evidence" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain "HPA045642: " 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.4 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L30 ENSG00000228856 "Ubiquitin specific peptidase 17-like family member 30" Q0WX57 4 9363129-9364721 "Enzymes, Predicted intracellular proteins" "Apoptosis, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "No human protein/transcript evidence" "Evidence at protein level" "Evidence at protein level" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain "HPA045642: " 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L4 ENSG00000236125 "Ubiquitin specific peptidase 17-like family member 4" A6NCW7 8 7337115-7338707 "Enzymes, Predicted intracellular proteins" "No human protein/transcript evidence" "No human protein/transcript evidence" "No human protein/transcript evidence" "No human protein/transcript evidence" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain "HPA045642: " 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L5 ENSG00000227140 "Ubiquitin specific peptidase 17-like family member 5" A8MUK1 4 9339403-9340995 "Enzymes, Predicted intracellular proteins" "Apoptosis, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "No human protein/transcript evidence" "No human protein/transcript evidence" "No human protein/transcript evidence" "No human protein/transcript evidence" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain "HPA045642: " 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP17L7 ENSG00000226430 "Ubiquitin specific peptidase 17-like family member 7" P0C7H9 8 12132417-12134438 "Enzymes, Predicted intracellular proteins" "No human protein/transcript evidence" "No human protein/transcript evidence" "No human protein/transcript evidence" "No human protein/transcript evidence" "Not detected" "Not detected" "Cell line enhanced" "Detected in single" "HEK 293: 1.1" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain "HPA045642: " "unprognostic (5.31e-2)" 0.1 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 1.1 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.3 0.0 0.0 0.0 0.1 0.5 0.1 0.2 0.0 0.1 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 USP17L8 ENSG00000237038 "Ubiquitin specific peptidase 17-like family member 8" P0C7I0 8 7971661-7973253 "Enzymes, Predicted intracellular proteins" "No human protein/transcript evidence" "No human protein/transcript evidence" "No human protein/transcript evidence" "No human protein/transcript evidence" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045642 Uncertain "HPA045642: " 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 USP18 ENSG00000184979 "Ubiquitin specific peptidase 18" Q9UMW8 22 18149899-18177397 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell line enhanced" "Detected in many" "BJ hTERT+ SV40 Large T+: 48.0;BJ hTERT+ SV40 Large T+ RasG12V: 52.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in all" HPA044768 Uncertain Approved Cytosol Cytosol "HPA044768: AB_10963697" "unprognostic (2.06e-1)" "unprognostic (3.55e-2)" "unprognostic (1.57e-2)" "unprognostic (5.04e-3)" "unprognostic (1.40e-2)" "unprognostic (5.42e-2)" "unprognostic (3.29e-2)" "unprognostic (5.11e-3)" "unprognostic (1.81e-1)" "unprognostic (1.79e-3)" "unprognostic (9.77e-2)" "unprognostic (1.47e-1)" "unprognostic (4.29e-3)" "unprognostic (2.58e-1)" "unprognostic (2.77e-2)" "unprognostic (2.28e-2)" "unprognostic (8.38e-2)" 20.4 6.4 4.8 13.0 4.8 6.3 15.4 1.9 5.5 5.3 6.3 5.6 3.2 5.2 6.1 9.5 6.0 6.5 7.1 5.4 4.4 4.6 8.8 20.9 14.0 15.9 4.3 4.8 4.9 4.2 3.8 7.8 7.6 4.7 4.8 3.9 5.7 11.7 2.3 9.7 4.2 15.5 4.5 4.1 10.6 6.4 10.6 4.0 22.4 10.6 2.9 7.7 4.3 6.9 4.1 2.9 6.6 8.8 11.0 11.0 4.8 3.7 3.7 1.1 4.8 4.9 3.6 4.9 1.9 4.5 48.0 52.3 0.6 5.2 0.0 2.9 1.0 1.3 5.6 1.6 1.6 16.4 7.8 7.2 0.5 6.8 0.5 1.7 6.9 1.6 0.6 3.4 0.0 10.6 0.3 0.4 0.4 6.3 8.3 4.2 3.4 2.9 3.3 7.5 0.0 0.9 3.1 4.0 3.2 2.3 3.9 17.8 2.6 1.7 17.4 0.3 0.9 1.1 1.9 0.9 11.2 0.0 4.3 4.3 2.7 2.7 3.2 6.6 7.8 8.8 10.0 4.1 6.7 10.1 1.6 2.7 7.9 8.8 0.5 11.0 6.6 2.9 11.0 4.8 4.8 4.8 1.9 4.0 4.4 4.6 4.3 4.8 4.7 4.0 USP19 "KIAA0891, ZMYND9" ENSG00000172046 "Ubiquitin specific peptidase 19" O94966 3 49108046-49120938 "Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "unprognostic (3.23e-2)" "unprognostic (2.12e-1)" "unprognostic (5.91e-2)" "unprognostic (1.37e-1)" "unprognostic (1.92e-2)" "unprognostic (3.90e-3)" "unprognostic (2.99e-2)" "unprognostic (3.00e-3)" "unprognostic (2.69e-1)" "unprognostic (3.65e-2)" "unprognostic (2.31e-2)" "unprognostic (1.26e-1)" "prognostic favourable (7.05e-9)" "unprognostic (2.99e-1)" "unprognostic (2.11e-1)" "unprognostic (1.72e-3)" "unprognostic (7.54e-2)" 13.9 19.5 10.3 14.6 12.2 16.2 14.9 19.4 37.1 17.0 16.3 12.5 19.6 14.6 18.7 17.9 14.3 17.2 19.9 17.9 10.3 9.4 14.8 16.5 14.7 13.8 11.9 9.5 17.2 15.2 22.4 13.2 17.6 11.4 14.2 10.9 14.9 24.7 26.0 57.3 18.4 16.1 13.9 8.5 17.5 15.1 14.9 11.7 23.0 17.7 15.2 12.6 17.4 14.1 5.1 6.7 12.3 5.7 4.3 8.4 5.3 8.1 11.8 14.1 19.9 17.4 11.9 18.0 9.2 12.3 17.2 13.1 11.8 12.5 17.6 9.4 11.5 10.9 17.8 13.4 7.2 13.8 13.8 17.1 23.6 10.8 18.0 19.4 18.1 16.9 10.4 16.2 11.8 11.3 13.4 13.3 8.6 10.6 18.4 20.1 26.7 17.3 8.9 10.4 20.4 10.6 15.6 7.8 22.2 13.6 17.9 16.0 12.1 25.8 8.9 11.5 14.0 17.0 13.9 33.7 32.6 15.6 14.8 15.4 14.3 12.3 4.9 7.5 7.2 5.3 6.8 4.6 5.8 8.4 6.7 5.1 5.7 6.2 8.8 4.3 5.7 3.0 4.1 5.3 10.3 12.2 19.4 37.1 10.3 9.4 11.9 9.5 11.4 11.7 USP2 UBP41 ENSG00000036672 "Ubiquitin specific peptidase 2" O75604 11 119355215-119381726 "Enzymes, Predicted intracellular proteins" "Biological rhythms, Cell cycle, Myogenesis, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "skeletal muscle: 79.9" "Cell line enriched" "Detected in many" 4 "U-266/70: 34.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Cell type enhanced" "Detected in single" "naive CD4 T-cell: 1.3" "Lineage enriched" "Detected in single" 13 "T-cells: 1.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA006777, HPA007222" Approved Supported "Plasma membrane,Cytosol" Cytosol "Plasma membrane" "HPA006777: AB_1080507, HPA007222: AB_1080505" "unprognostic (6.83e-2)" "unprognostic (2.02e-2)" "unprognostic (5.54e-2)" "unprognostic (1.37e-2)" "unprognostic (1.25e-1)" "unprognostic (7.46e-3)" "unprognostic (1.00e-1)" "unprognostic (5.27e-2)" "unprognostic (1.24e-1)" "unprognostic (5.24e-3)" "unprognostic (8.02e-3)" "unprognostic (7.33e-2)" "prognostic favourable (3.09e-11)" "unprognostic (1.58e-1)" "unprognostic (1.20e-1)" "unprognostic (1.96e-2)" "unprognostic (2.66e-2)" 3.1 4.8 6.9 1.4 12.2 1.5 1.6 12.6 16.1 2.5 5.9 10.0 0.0 7.9 2.6 6.4 5.9 7.0 2.2 26.8 5.7 3.1 29.7 10.6 2.2 0.7 5.7 6.2 2.9 10.1 18.4 7.6 1.3 6.7 2.3 3.9 19.1 3.2 2.4 79.9 4.6 11.7 4.2 3.8 0.8 2.7 36.1 8.8 0.0 2.2 25.2 1.0 1.9 2.0 0.0 0.0 0.0 0.0 0.0 1.3 0.3 3.4 0.3 0.5 1.9 0.1 0.1 0.7 0.4 0.2 0.0 0.3 3.6 0.5 5.9 1.1 0.6 0.6 4.7 1.7 0.1 4.2 0.6 1.7 2.5 7.3 1.6 0.0 1.6 0.6 0.3 0.4 1.2 0.3 8.2 0.5 1.0 2.4 0.0 0.4 0.9 0.7 0.0 1.3 0.8 2.7 0.2 7.2 2.2 2.0 1.6 0.4 5.3 3.6 0.0 0.0 0.9 0.5 0.5 34.4 7.6 0.1 0.0 1.1 0.8 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.3 0.7 0.0 0.0 1.3 0.7 0.0 0.0 0.0 0.0 0.3 0.3 6.9 12.2 12.6 16.1 5.7 3.1 5.7 6.2 6.7 8.8 USP20 KIAA1003 ENSG00000136878 "Ubiquitin specific peptidase 20" Q9Y2K6 9 129834698-129881838 "Enzymes, Predicted intracellular proteins" "Endocytosis, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell line enhanced" "Detected in all" "K-562: 30.4;MOLT-4: 27.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA006287, HPA007008" Uncertain Supported Approved "Nucleoplasm,Plasma membrane,Cytosol" "Nucleoplasm, Plasma membrane, Cytosol" "HPA006287: AB_1080510, HPA007008: " "unprognostic (2.64e-2)" "prognostic favourable (8.01e-4)" "prognostic unfavourable (2.48e-4)" "prognostic favourable (4.01e-4)" "unprognostic (4.69e-1)" "unprognostic (1.89e-2)" "unprognostic (2.25e-1)" "unprognostic (2.55e-3)" "unprognostic (1.24e-1)" "unprognostic (7.89e-2)" "prognostic favourable (1.54e-7)" "unprognostic (2.09e-1)" "prognostic favourable (5.65e-5)" "unprognostic (1.76e-2)" "unprognostic (1.20e-1)" "unprognostic (1.19e-2)" "unprognostic (1.24e-2)" 7.8 13.2 10.5 15.2 14.6 24.4 8.5 23.0 19.6 13.2 12.1 12.7 10.2 9.7 13.3 6.2 9.3 11.6 12.5 8.8 10.5 13.7 8.0 7.3 9.1 19.6 9.6 16.1 16.8 12.9 11.5 19.0 8.0 11.9 14.9 6.1 10.8 13.7 17.2 10.2 14.0 11.8 20.0 8.8 14.6 10.2 14.0 8.8 51.5 19.3 4.2 15.3 15.6 10.0 3.8 2.4 4.8 1.7 9.0 10.7 5.4 3.0 2.9 5.2 7.0 6.8 5.8 7.4 4.9 4.1 3.7 2.6 2.4 3.3 4.1 4.2 4.7 7.6 3.1 3.5 1.5 22.2 4.1 7.6 8.0 1.6 4.8 7.1 5.7 5.1 5.1 4.9 3.7 4.0 30.4 5.1 2.2 8.0 27.8 16.9 4.1 7.0 4.7 5.8 7.0 2.9 3.3 1.1 5.8 5.7 7.2 4.6 7.5 10.0 5.9 4.1 1.9 5.5 3.2 5.1 7.4 2.9 8.2 9.4 3.8 1.0 1.7 4.8 8.6 1.4 9.3 3.7 8.8 8.3 2.4 3.8 10.4 8.9 2.8 9.0 1.3 2.1 10.7 5.4 10.5 14.6 23.0 19.6 10.5 13.7 9.6 16.1 11.9 8.8 USP21 "USP16, USP23" ENSG00000143258 "Ubiquitin specific peptidase 21" Q9UK80 1 161159450-161165723 "Enzymes, Predicted intracellular proteins" "Transcription, Transcription regulation, Ubl conjugation pathway" "Activator, Chromatin regulator, Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA028397 Uncertain Approved Supported "Nucleoplasm,Plasma membrane,Cytosol" Cytosol "Nucleoplasm, Plasma membrane" "HPA028397: AB_10603227" "unprognostic (9.17e-2)" "unprognostic (1.44e-1)" "unprognostic (3.95e-2)" "prognostic unfavourable (7.05e-4)" "unprognostic (1.22e-2)" "unprognostic (1.26e-2)" "prognostic unfavourable (1.68e-4)" "unprognostic (5.35e-2)" "unprognostic (6.73e-2)" "unprognostic (2.76e-2)" "unprognostic (3.87e-3)" "unprognostic (1.31e-2)" "prognostic unfavourable (9.50e-6)" "unprognostic (2.45e-1)" "unprognostic (3.28e-1)" "unprognostic (2.13e-2)" "prognostic favourable (3.35e-5)" 11.8 16.4 22.1 12.8 21.2 15.3 19.1 23.6 24.8 18.1 16.1 25.5 14.0 15.5 19.7 14.6 18.3 33.3 14.1 13.7 20.9 12.1 15.4 10.6 14.0 16.7 26.4 14.1 28.3 19.0 24.4 17.2 15.2 20.5 18.1 13.1 17.1 19.0 25.3 19.4 23.5 15.4 15.1 17.0 18.7 16.0 17.0 22.9 16.0 24.5 9.6 15.6 17.9 19.2 14.1 12.0 18.3 11.1 13.4 17.2 10.7 7.4 12.8 16.9 16.3 13.5 11.3 10.4 5.5 9.0 15.2 11.9 11.8 14.7 9.7 9.5 6.8 12.9 10.9 10.7 8.4 18.5 18.3 11.6 18.5 9.2 9.7 10.3 8.7 9.5 14.4 10.4 15.0 10.7 17.1 13.6 9.6 13.7 18.2 16.2 15.8 16.3 17.3 5.6 16.3 8.9 8.9 15.4 19.8 10.3 10.8 8.3 23.8 16.6 6.2 10.9 9.7 7.6 9.4 27.5 21.3 14.4 10.0 8.9 9.8 13.0 11.1 18.3 14.9 7.1 17.2 12.8 13.8 15.4 12.0 14.1 16.0 14.6 9.6 13.4 7.7 12.0 13.3 10.7 22.1 21.2 23.6 24.8 20.9 12.1 26.4 14.1 20.5 22.9 USP22 "KIAA1063, USP3L" ENSG00000124422 "Ubiquitin specific peptidase 22" Q9UPT9 17 20999593-21043760 "Enzymes, Predicted intracellular proteins" "Cell cycle, Transcription, Transcription regulation, Ubl conjugation pathway" "Activator, Chromatin regulator, Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA044980 Supported Approved "Nuclear speckles" "Nuclear speckles" "HPA044980: AB_10794503" "unprognostic (7.24e-2)" "unprognostic (5.38e-2)" "unprognostic (7.67e-2)" "unprognostic (6.19e-2)" "unprognostic (4.72e-1)" "unprognostic (1.11e-2)" "prognostic unfavourable (9.66e-4)" "unprognostic (2.17e-2)" "unprognostic (7.81e-2)" "unprognostic (6.37e-2)" "unprognostic (1.07e-3)" "unprognostic (5.68e-2)" "prognostic favourable (1.53e-7)" "unprognostic (8.95e-2)" "unprognostic (1.93e-1)" "unprognostic (2.91e-1)" "unprognostic (1.79e-2)" 22.5 33.0 40.7 21.5 49.5 25.9 24.6 66.1 66.4 26.8 23.6 31.9 25.1 18.9 36.7 29.3 21.9 33.9 23.0 44.1 38.7 47.6 27.7 22.9 26.1 25.1 31.0 40.7 45.6 24.5 47.4 32.2 22.4 35.1 27.5 20.5 28.7 20.0 29.5 47.6 22.1 21.1 31.2 24.8 23.7 22.7 20.2 23.7 41.2 32.8 24.8 27.3 25.1 23.2 13.7 12.1 13.4 13.3 8.9 15.5 6.9 21.6 39.4 38.3 32.9 22.4 23.3 18.3 25.0 19.3 22.6 19.2 45.4 9.8 29.8 24.1 38.4 23.4 37.1 29.8 33.8 14.2 25.7 24.7 26.2 22.0 26.5 27.1 21.6 25.6 17.9 25.5 26.9 28.1 28.0 10.8 31.9 22.3 37.9 12.9 19.7 13.0 42.0 60.6 20.3 20.8 31.9 18.5 38.1 32.3 13.4 26.3 22.5 16.1 35.6 23.1 30.7 23.6 33.8 11.7 15.6 99.0 23.5 14.5 35.6 6.8 13.3 12.6 11.0 9.8 11.1 10.9 11.7 10.9 12.1 13.7 15.5 14.6 13.4 8.9 12.2 10.2 7.8 6.9 40.7 49.5 66.1 66.4 38.7 47.6 31.0 40.7 35.1 23.7 USP24 KIAA1057 ENSG00000162402 "Ubiquitin specific peptidase 24" Q9UPU5 1 55066359-55215113 "Enzymes, Predicted intracellular proteins" "Host-virus interaction, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 46.0" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA026723, HPA028428, HPA067124" Approved Supported Nucleoplasm,Cytosol Nucleoplasm Cytosol "HPA026723: AB_10599851, HPA028428: AB_10600991, HPA067124: " "unprognostic (2.28e-1)" "unprognostic (9.81e-3)" "unprognostic (4.70e-3)" "unprognostic (4.86e-3)" "unprognostic (9.31e-3)" "unprognostic (4.84e-3)" "prognostic unfavourable (1.34e-7)" "unprognostic (2.04e-1)" "unprognostic (6.93e-2)" "unprognostic (2.98e-1)" "unprognostic (5.08e-2)" "unprognostic (1.86e-1)" "unprognostic (8.12e-2)" "unprognostic (1.79e-1)" "unprognostic (6.42e-2)" "unprognostic (4.12e-2)" "unprognostic (1.64e-1)" 12.3 7.6 7.5 12.1 8.8 30.1 10.6 20.1 8.5 7.8 10.2 6.8 10.6 5.0 10.1 7.0 7.7 6.9 7.0 14.7 7.9 6.4 10.4 9.3 7.6 12.7 8.0 5.6 10.9 7.3 15.5 16.9 5.8 6.9 7.6 8.5 5.1 9.7 10.7 46.0 8.9 8.7 7.3 6.2 10.9 7.8 4.9 8.7 16.4 7.4 11.5 12.7 9.7 13.7 6.0 10.5 5.9 2.2 3.8 4.5 1.1 17.8 9.8 12.3 6.7 16.1 14.1 14.2 7.9 10.0 11.4 11.9 14.0 6.3 14.3 8.8 14.6 14.5 16.3 13.3 17.9 15.0 9.9 28.7 21.5 16.3 9.6 19.7 22.3 12.3 11.9 17.3 19.7 10.3 26.4 6.0 15.2 4.2 11.9 10.5 18.1 11.9 12.3 15.7 6.2 19.8 12.1 10.9 7.6 13.5 9.7 11.8 6.7 9.8 13.9 10.4 10.1 12.5 12.6 7.6 5.7 18.8 9.9 16.5 9.3 5.9 2.0 2.5 4.5 1.8 2.8 4.8 3.5 3.5 1.8 6.0 3.2 4.2 2.3 3.8 2.2 10.5 1.9 1.1 7.5 8.8 20.1 8.5 7.9 6.4 8.0 5.6 6.9 8.7 USP25 USP21 ENSG00000155313 "Ubiquitin specific peptidase 25" Q9UHP3 21 15730025-15880069 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA018297, HPA024142" Approved Supported Cytosol Cytosol "HPA018297: AB_1858672, HPA024142: AB_1858673" "unprognostic (6.35e-2)" "unprognostic (1.50e-1)" "unprognostic (6.90e-2)" "unprognostic (6.29e-2)" "unprognostic (1.39e-1)" "unprognostic (2.88e-2)" "unprognostic (3.91e-2)" "unprognostic (1.65e-1)" "unprognostic (1.44e-2)" "unprognostic (1.38e-1)" "unprognostic (2.33e-2)" "unprognostic (1.40e-1)" "unprognostic (8.24e-3)" "unprognostic (2.34e-3)" "unprognostic (4.50e-2)" "unprognostic (1.61e-1)" "unprognostic (2.32e-2)" 14.9 8.5 11.0 14.2 15.5 12.4 28.7 11.3 11.1 17.5 11.8 6.6 17.8 6.5 20.7 14.5 12.6 10.6 10.1 17.8 9.9 5.8 12.9 10.4 22.1 14.8 7.6 7.1 14.5 8.2 8.1 8.4 17.7 7.7 12.9 8.6 7.8 11.4 13.6 56.3 8.3 12.3 19.2 7.3 11.6 9.0 26.1 7.5 16.5 10.5 14.6 9.6 13.8 18.1 3.1 2.8 5.8 2.9 2.3 7.2 1.6 13.0 9.9 9.4 1.4 17.3 25.9 11.0 9.4 9.4 7.0 8.9 8.6 7.5 14.1 13.9 14.8 7.0 7.2 12.4 9.7 14.0 8.2 11.5 10.5 6.6 28.8 15.2 5.3 16.8 15.2 11.3 32.7 24.5 14.8 26.6 12.6 5.4 17.3 2.9 11.5 8.8 13.2 8.7 10.7 19.0 3.5 2.0 5.6 13.4 11.4 8.7 6.1 8.9 23.3 10.9 7.1 11.4 5.2 7.8 4.7 11.2 7.1 6.8 8.0 0.0 2.9 3.6 4.0 2.8 4.4 3.1 3.4 7.2 2.5 2.2 3.2 4.8 5.8 2.3 2.5 2.8 4.4 1.6 11.0 15.5 11.3 11.1 9.9 5.8 7.6 7.1 7.7 7.5 USP26 ENSG00000134588 "Ubiquitin specific peptidase 26" Q9BXU7 X 133024631-133097109 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 7 "testis: 3.8" "Low cell line specificity" "Detected in some" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "unprognostic (7.92e-4)" "unprognostic (3.59e-2)" "unprognostic (1.99e-2)" "unprognostic (2.08e-1)" 0.1 0.1 0.1 0.1 0.1 0.3 0.5 0.1 0.1 0.1 0.1 0.1 0.1 0.0 0.2 0.4 0.1 0.1 0.2 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.2 0.1 0.1 0.2 0.2 0.4 0.1 0.1 0.1 0.1 0.1 3.8 0.1 0.1 0.1 0.1 0.3 0.1 0.1 0.2 0.1 0.5 0.1 0.2 0.3 0.0 0.0 0.5 0.4 0.5 0.4 0.1 0.1 0.2 0.2 0.7 0.1 0.2 0.1 0.7 0.1 0.1 0.1 0.7 0.1 0.2 0.3 1.0 0.3 1.0 0.3 0.1 0.1 0.0 1.5 0.6 0.4 0.1 0.1 0.4 0.4 0.2 0.2 0.1 0.7 0.4 0.3 0.4 0.1 0.0 0.9 0.5 0.5 0.2 0.1 0.1 0.2 0.1 0.7 0.3 0.9 0.1 0.3 0.4 0.9 0.3 0.1 0.2 0.4 0.3 0.2 0.1 0.2 0.1 0.1 0.0 0.0 0.1 0.0 0.1 0.2 0.0 0.0 0.5 0.2 0.0 0.0 0.3 0.0 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 USP27X USP27 ENSG00000273820 "Ubiquitin specific peptidase 27, X-linked" A6NNY8 X 49879948-49882565 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Disease mutation, Mental retardation" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low cell type specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA077264 Approved Nucleoplasm,Vesicles Vesicles Nucleoplasm "HPA077264: " "unprognostic (4.12e-2)" "unprognostic (9.58e-3)" "unprognostic (2.29e-1)" "unprognostic (4.66e-2)" "unprognostic (1.98e-1)" "unprognostic (1.74e-1)" "prognostic unfavourable (6.14e-4)" "unprognostic (3.10e-3)" "unprognostic (3.91e-2)" "unprognostic (1.31e-2)" "prognostic favourable (9.31e-4)" "unprognostic (5.37e-2)" "unprognostic (7.45e-3)" "unprognostic (1.19e-1)" "unprognostic (1.12e-1)" "unprognostic (2.01e-2)" "unprognostic (2.58e-1)" 1.8 3.3 1.8 5.9 2.9 0.3 7.7 1.7 7.4 3.9 5.9 4.8 2.2 1.1 12.7 4.1 3.1 4.7 3.8 3.9 2.2 3.5 3.5 6.1 1.9 1.3 3.2 8.8 3.2 4.1 0.8 15.5 2.8 4.1 1.7 4.1 5.2 3.9 7.5 2.6 4.7 3.9 1.3 2.0 1.9 3.8 1.9 2.8 3.2 3.6 2.2 3.7 3.1 1.7 1.0 0.7 0.7 0.3 1.3 0.4 2.1 5.6 6.5 7.5 6.2 5.0 5.4 2.4 4.1 2.8 2.3 10.0 2.5 1.4 2.3 6.4 3.6 9.3 6.2 4.1 2.9 4.3 2.3 1.6 9.2 4.2 0.7 5.1 7.0 4.2 4.0 4.0 3.9 4.6 2.4 4.5 5.3 3.5 2.0 7.0 3.9 3.7 5.6 0.5 4.6 2.1 1.7 4.9 4.8 4.5 5.8 5.2 1.7 2.9 3.3 6.4 5.7 0.9 2.2 0.5 1.0 3.8 2.0 3.6 0.7 0.4 0.1 0.6 0.4 0.8 0.6 0.5 0.3 1.0 1.7 0.8 0.6 0.7 0.3 0.7 0.4 1.3 0.4 USP28 KIAA1515 ENSG00000048028 "Ubiquitin specific peptidase 28" Q96RU2 11 113797874-113875570 "Enzymes, Predicted intracellular proteins" "DNA damage, DNA repair, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "heart muscle: 40.1;skeletal muscle: 50.2" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA006778, HPA006779" Enhanced Supported "Nucleoplasm,Nuclear bodies" Nucleoplasm "Nuclear bodies" "HPA006778: AB_1080520, HPA006779: AB_1080517" "unprognostic (2.54e-1)" "unprognostic (2.72e-1)" "unprognostic (2.99e-2)" "unprognostic (3.72e-2)" "unprognostic (5.51e-2)" "unprognostic (2.30e-1)" "unprognostic (9.73e-3)" "unprognostic (3.00e-1)" "unprognostic (2.04e-3)" "unprognostic (1.82e-3)" "unprognostic (3.17e-2)" "unprognostic (1.19e-1)" "unprognostic (5.11e-2)" "unprognostic (2.06e-2)" "unprognostic (9.03e-2)" "unprognostic (1.35e-3)" "unprognostic (5.03e-2)" 3.9 3.4 4.8 8.6 5.7 2.4 5.7 26.4 8.6 11.6 5.1 4.9 14.0 4.7 6.0 6.0 5.7 5.0 4.0 40.1 5.0 4.8 5.1 5.6 5.1 7.2 6.8 4.5 7.5 4.1 10.6 9.7 3.9 4.8 8.9 6.0 5.7 5.7 12.2 50.2 3.5 5.1 11.6 6.4 6.9 4.4 5.5 3.8 3.6 5.1 10.1 7.7 7.1 4.6 10.3 4.1 2.1 3.7 17.9 16.2 6.0 10.3 11.6 15.7 20.7 12.8 12.7 11.1 7.6 10.5 10.3 17.7 17.1 14.9 13.7 17.4 10.3 20.3 22.1 14.3 14.4 15.3 10.0 7.3 8.1 9.2 7.9 9.4 7.3 7.6 10.9 11.9 14.2 18.6 12.6 8.9 10.8 5.2 7.1 15.3 18.8 8.4 17.6 21.8 16.6 11.4 10.2 6.9 7.4 18.1 6.2 5.9 15.1 3.3 9.8 11.5 17.2 10.4 7.8 6.1 8.7 11.6 1.1 18.3 7.4 0.1 3.2 2.1 16.2 2.4 8.4 10.3 4.1 11.4 4.1 8.4 2.7 9.4 0.9 17.9 3.7 1.2 5.6 6.0 4.8 5.7 26.4 8.6 5.0 4.8 6.8 4.5 4.8 3.8 USP29 ENSG00000131864 "Ubiquitin specific peptidase 29" Q9HBJ7 19 57119138-57131926 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Group enriched" "Detected in some" 5 "blood: 4.1;bone marrow: 2.7;pancreas: 2.1;skin 1: 2.3;testis: 8.4" "Cell line enhanced" "Detected in some" "BEWO: 3.3;HEK 293: 3.2" "Not detected" "Not detected" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Not detected" "Not detected" HPA076515 Enhanced "HPA076515: " "unprognostic (1.32e-1)" 0.1 0.1 0.2 0.0 0.2 2.7 0.1 0.1 0.4 0.1 0.1 0.0 0.1 0.0 0.1 0.1 0.0 0.6 0.3 0.2 0.1 0.1 0.1 0.3 0.1 0.2 2.1 0.0 0.1 0.0 0.1 0.0 0.7 0.0 0.2 2.3 0.1 0.0 0.1 0.1 0.4 8.4 0.4 0.0 0.7 0.1 1.1 1.9 4.1 1.1 1.2 0.8 0.6 0.1 0.7 0.8 0.3 0.0 0.0 3.3 0.0 0.0 0.1 0.1 1.7 0.0 0.9 0.0 0.0 2.0 0.0 0.0 0.0 1.0 3.2 0.8 0.0 0.0 1.1 0.0 1.9 0.9 1.0 1.4 0.0 0.0 0.3 0.9 0.0 0.7 0.0 1.2 0.0 1.0 0.9 0.0 1.0 0.0 2.1 2.0 0.7 0.6 0.4 0.2 0.8 1.3 1.5 1.2 0.5 0.0 0.0 1.6 0.5 1.5 0.5 0.8 0.0 3.1 1.1 1.1 0.8 0.7 0.6 0.5 0.7 0.3 0.3 1.1 0.7 0.7 4.1 1.2 0.4 1.9 0.5 0.6 USP3 ENSG00000140455 "Ubiquitin specific peptidase 3" Q9Y6I4 15 63504511-63594640 "Enzymes, Predicted intracellular proteins" "Cell cycle, DNA damage, Ubl conjugation pathway" "Chromatin regulator, Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Region enriched" "Detected in all" 4 "cerebellum: 33.4" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA053275, HPA060513, HPA077975" Supported Nucleoplasm "Intracellular and membrane" Nucleoplasm "HPA053275: , HPA060513: , HPA077975: " "unprognostic (4.63e-3)" "unprognostic (2.71e-1)" "unprognostic (7.88e-2)" "unprognostic (3.33e-2)" "unprognostic (2.16e-2)" "unprognostic (6.03e-2)" "unprognostic (6.26e-2)" "unprognostic (4.52e-2)" "unprognostic (1.62e-2)" "unprognostic (2.36e-1)" "unprognostic (3.54e-2)" "unprognostic (4.87e-2)" "unprognostic (1.17e-1)" "unprognostic (8.61e-2)" "unprognostic (2.78e-1)" "unprognostic (6.21e-2)" "prognostic favourable (1.38e-4)" 16.0 9.0 5.9 20.4 6.5 38.6 21.3 33.4 6.6 12.7 19.1 6.0 16.8 16.2 18.1 13.3 13.6 10.4 14.2 7.6 6.6 4.4 12.9 10.8 17.5 28.2 8.1 3.9 19.5 27.1 7.1 8.2 10.2 7.9 12.4 11.5 8.2 18.5 14.8 12.4 15.9 19.0 16.1 8.0 23.6 14.7 10.3 7.8 22.7 12.5 11.4 22.5 21.3 17.9 11.4 20.6 52.6 28.1 7.2 12.9 13.4 9.2 30.1 15.6 9.7 7.7 12.6 13.7 7.9 9.9 7.7 9.4 11.8 17.3 9.3 12.6 7.8 11.7 14.5 12.3 7.5 15.3 7.8 10.6 10.7 12.7 6.5 6.2 12.8 9.0 16.2 9.3 16.2 16.6 14.0 11.9 4.9 14.3 13.0 10.2 19.7 13.0 19.1 9.4 16.5 9.2 31.6 13.7 10.6 4.9 16.1 9.7 9.7 12.2 15.8 8.9 18.5 5.2 10.5 10.8 19.9 20.8 8.5 17.4 7.3 28.8 28.1 3.5 8.4 22.6 9.3 10.3 11.9 8.6 20.6 11.4 12.9 9.3 52.6 7.2 18.7 4.1 9.1 13.4 5.9 6.5 33.4 6.6 6.6 4.4 8.1 3.9 7.9 7.8 USP30 "FLJ40511, MGC10702" ENSG00000135093 "Ubiquitin specific peptidase 30" Q70CQ3 12 109023089-109088026 "Enzymes, Predicted intracellular proteins, Predicted membrane proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA016952 Approved "HPA016952: AB_1858680" "unprognostic (2.34e-1)" "unprognostic (1.57e-2)" "unprognostic (7.04e-2)" "unprognostic (9.91e-2)" "unprognostic (2.48e-1)" "unprognostic (5.89e-2)" "unprognostic (1.91e-1)" "unprognostic (3.60e-3)" "unprognostic (1.98e-1)" "unprognostic (4.96e-2)" "unprognostic (5.07e-2)" "unprognostic (1.07e-1)" "prognostic favourable (5.23e-6)" "unprognostic (2.49e-1)" "unprognostic (1.23e-1)" "unprognostic (1.12e-1)" "unprognostic (1.02e-3)" 11.7 18.9 12.7 9.0 17.6 12.2 10.4 11.9 21.0 10.3 13.2 29.2 13.6 14.9 12.4 8.5 9.2 11.1 8.4 9.0 10.3 10.6 12.4 21.7 8.9 10.4 16.6 7.8 17.5 12.4 14.7 13.0 6.7 16.0 9.4 11.3 16.4 10.1 12.4 16.4 13.6 14.1 8.6 14.3 9.8 8.5 21.3 16.3 8.7 11.1 5.3 7.1 10.8 8.1 14.2 12.2 12.7 11.0 18.3 17.4 6.0 4.7 3.6 9.7 8.3 6.8 7.8 5.4 5.3 6.9 6.2 5.5 4.3 3.6 11.9 4.5 5.2 5.3 8.4 5.5 7.1 13.8 10.6 3.8 3.3 6.1 7.3 7.6 4.3 9.4 6.7 5.5 5.4 7.1 5.7 5.8 5.2 5.5 11.9 4.3 3.0 10.2 12.9 6.9 7.2 5.0 5.7 8.8 7.9 7.2 5.4 5.6 13.4 5.9 5.1 5.7 3.1 5.5 3.5 14.6 12.1 17.9 6.1 4.6 6.3 9.5 7.1 12.7 15.4 11.0 17.4 14.2 12.9 14.3 4.6 14.2 13.7 12.6 4.2 18.3 8.8 12.2 11.2 6.0 12.7 17.6 11.9 21.0 10.3 10.6 16.6 7.8 16.0 16.3 USP31 KIAA1203 ENSG00000103404 "Ubiquitin specific peptidase 31" Q70CQ4 16 23061406-23149270 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA006937 Uncertain Approved Cytosol Cytosol "HPA006937: AB_1080523" "unprognostic (6.45e-2)" "unprognostic (2.42e-1)" "unprognostic (1.08e-1)" "unprognostic (4.43e-3)" "unprognostic (1.24e-1)" "unprognostic (1.28e-1)" "unprognostic (1.23e-1)" "unprognostic (1.29e-1)" "unprognostic (1.03e-1)" "unprognostic (2.52e-1)" "unprognostic (6.15e-2)" "unprognostic (2.01e-1)" "prognostic unfavourable (4.41e-5)" "unprognostic (5.59e-2)" "unprognostic (3.75e-1)" "unprognostic (3.07e-1)" "unprognostic (1.98e-3)" 6.3 5.3 11.2 4.0 16.6 7.1 8.7 12.7 16.5 10.9 4.9 19.7 2.6 3.7 15.3 7.7 9.3 6.5 4.1 11.0 9.0 6.3 6.2 7.7 7.3 3.6 24.6 8.1 3.7 6.3 20.6 10.4 7.4 17.4 9.6 4.9 2.8 6.0 8.5 10.9 15.9 3.4 14.2 14.8 2.8 3.5 20.7 19.3 1.7 4.2 2.4 4.9 13.4 9.5 0.5 0.8 0.6 1.3 0.1 2.1 0.2 9.4 10.0 2.9 4.0 5.3 4.1 2.7 3.3 3.0 4.3 5.1 6.3 5.8 3.2 3.5 4.1 12.5 7.1 12.9 7.1 2.3 2.9 1.3 5.8 13.2 6.6 3.3 3.6 3.5 11.2 7.9 18.3 7.6 3.8 9.9 5.8 6.5 1.6 2.7 5.7 3.1 7.9 8.1 6.3 6.4 14.2 7.7 5.0 5.1 10.2 2.9 4.1 7.3 4.4 8.7 6.4 4.4 8.9 3.3 5.4 3.4 6.2 4.4 3.4 0.1 0.7 0.6 0.8 0.3 2.1 0.1 0.7 1.5 0.8 0.5 0.8 0.8 0.1 0.1 1.3 0.2 1.3 0.2 11.2 16.6 12.7 16.5 9.0 6.3 24.6 8.1 17.4 19.3 USP32 "NY-REN-60, USP10" ENSG00000170832 "Ubiquitin specific peptidase 32" Q8NFA0 17 60179094-60422470 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "testis: 58.4" "Cell line enhanced" "Detected in all" "MCF7: 60.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Cell type enhanced" "Detected in many" "plasmacytoid DC: 28.4" "Group enriched" "Detected in many" 10 "dendritic cells: 28.4;granulocytes: 13.5" HPA044365 Approved Approved "Golgi apparatus,Cytosol" "Golgi apparatus" Cytosol "HPA044365: " "unprognostic (4.10e-2)" "unprognostic (3.38e-2)" "unprognostic (3.57e-2)" "prognostic unfavourable (1.50e-4)" "unprognostic (2.15e-1)" "unprognostic (4.33e-2)" "unprognostic (1.90e-3)" "unprognostic (2.33e-2)" "unprognostic (2.24e-1)" "unprognostic (3.93e-1)" "unprognostic (6.49e-2)" "unprognostic (2.78e-1)" "unprognostic (2.82e-1)" "unprognostic (1.97e-1)" "unprognostic (7.23e-2)" "unprognostic (8.35e-2)" "unprognostic (4.16e-2)" 9.5 13.9 17.3 10.8 19.5 20.6 10.9 14.6 20.3 8.0 8.5 18.9 7.9 7.2 8.2 5.4 13.1 7.4 9.1 11.1 14.7 12.2 15.5 19.7 12.5 8.6 18.8 14.3 7.4 8.5 17.3 11.4 9.8 19.2 8.7 8.9 11.6 8.2 9.0 23.0 12.2 7.2 9.8 16.5 12.1 8.1 58.4 18.1 7.3 15.6 7.9 8.5 8.8 8.5 1.4 28.4 13.5 2.1 0.6 1.1 0.9 10.9 12.5 6.6 10.6 16.8 15.8 6.3 9.0 13.5 11.7 15.1 6.5 7.1 6.8 7.5 16.5 5.8 11.3 12.4 20.7 5.1 5.0 13.5 9.9 7.1 16.8 10.7 12.4 14.8 9.1 15.8 14.6 12.8 13.7 5.6 14.5 60.4 10.8 7.6 7.8 6.0 5.2 17.6 4.1 12.3 8.0 4.7 7.0 7.4 2.2 11.5 9.2 14.9 10.8 17.9 18.7 11.2 8.3 5.8 11.0 6.3 8.9 8.4 11.6 4.3 2.1 7.2 1.0 1.8 0.7 1.4 0.7 0.8 4.1 1.1 0.5 1.0 13.5 0.6 2.0 28.4 1.1 0.9 17.3 19.5 14.6 20.3 14.7 12.2 18.8 14.3 19.2 18.1 USP33 "KIAA1097, VDU1" ENSG00000077254 "Ubiquitin specific peptidase 33" Q8TEY7 1 77695987-77759852 "Enzymes, Predicted intracellular proteins" "Endocytosis, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" HPA005719 Uncertain Supported "Nucleoplasm,Golgi apparatus" "Nucleoplasm, Golgi apparatus" "HPA005719: AB_10601708" "unprognostic (2.31e-3)" "unprognostic (2.73e-2)" "unprognostic (1.04e-2)" "unprognostic (2.36e-1)" "unprognostic (9.19e-3)" "unprognostic (1.88e-3)" "unprognostic (1.22e-2)" "unprognostic (6.06e-2)" "unprognostic (2.48e-1)" "unprognostic (2.25e-1)" "unprognostic (2.67e-1)" "unprognostic (3.59e-1)" "unprognostic (5.36e-3)" "unprognostic (4.89e-2)" "unprognostic (5.76e-2)" "unprognostic (2.19e-1)" "unprognostic (2.02e-2)" 30.8 27.1 28.1 18.8 32.1 24.6 28.6 55.3 37.5 21.6 20.4 20.6 18.5 20.2 23.3 23.0 17.8 19.2 21.7 17.0 30.7 30.6 26.0 20.3 21.0 20.7 26.0 25.4 25.3 17.0 28.8 23.4 34.6 38.7 24.6 21.0 21.4 19.5 19.8 16.3 19.4 23.8 19.8 21.4 22.3 19.5 19.9 21.6 27.8 25.1 12.9 20.3 21.0 20.0 15.7 12.2 33.2 18.4 12.3 17.8 10.6 16.3 7.5 25.9 17.9 37.3 32.6 22.3 17.9 17.1 21.9 24.6 9.9 14.1 12.2 17.0 17.4 12.9 18.8 12.3 26.8 11.2 14.7 43.1 18.3 8.6 23.2 14.7 10.9 24.0 9.7 21.1 15.5 19.4 16.8 10.7 16.4 6.3 13.2 14.7 25.0 14.8 12.8 27.3 8.6 20.6 16.8 21.8 16.8 12.5 16.7 25.0 9.3 16.0 16.2 20.2 14.4 20.3 16.9 8.7 11.1 11.9 15.3 17.4 10.2 33.2 15.4 20.0 15.1 15.0 15.3 13.4 14.7 15.2 11.5 15.7 17.8 15.6 20.9 12.3 18.4 12.2 13.2 10.6 28.1 32.1 55.3 37.5 30.7 30.6 26.0 25.4 38.7 21.6 USP34 "KIAA0570, KIAA0729" ENSG00000115464 "Ubiquitin specific peptidase 34" Q70CQ2 2 61187463-61470769 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway, Wnt signaling pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA025815, HPA070764" Uncertain Approved Nucleoplasm Nucleoplasm "HPA025815: AB_1858681, HPA070764: " "unprognostic (4.04e-2)" "unprognostic (8.21e-3)" "unprognostic (5.08e-2)" "unprognostic (3.14e-2)" "unprognostic (4.13e-2)" "unprognostic (1.43e-2)" "unprognostic (1.04e-1)" "unprognostic (2.66e-1)" "unprognostic (1.47e-1)" "unprognostic (2.90e-2)" "unprognostic (8.91e-2)" "unprognostic (4.62e-2)" "unprognostic (9.58e-2)" "unprognostic (1.66e-1)" "unprognostic (2.53e-1)" "unprognostic (6.34e-2)" "unprognostic (7.01e-2)" 17.2 19.6 31.8 37.2 25.6 24.8 28.3 77.1 35.5 22.5 22.7 14.4 31.1 11.4 22.2 44.5 18.6 17.5 20.0 16.9 30.5 24.0 20.5 21.5 29.7 34.2 22.0 21.2 24.7 17.2 33.5 40.3 13.4 22.0 22.7 21.5 21.2 16.9 45.2 27.0 31.6 21.0 22.7 20.8 24.8 19.3 26.4 25.3 21.7 23.2 13.9 33.5 19.1 16.7 6.0 5.8 3.4 4.6 5.2 7.5 2.3 16.6 11.9 15.5 16.0 29.5 19.8 13.0 10.3 14.5 9.2 8.8 16.7 6.4 39.5 10.9 22.1 9.1 12.2 13.5 17.2 14.1 9.6 23.9 11.6 26.8 24.8 17.7 15.2 21.6 17.5 16.7 25.1 19.3 16.3 12.8 20.4 15.6 11.6 25.8 10.5 9.4 12.5 18.9 10.5 27.1 20.4 12.8 13.7 16.2 12.0 17.7 6.3 12.9 17.2 14.6 19.4 8.6 13.4 14.9 7.3 41.5 13.7 16.5 12.5 3.4 2.0 2.8 7.5 2.2 6.7 5.1 5.1 5.5 1.8 6.0 5.8 7.5 3.4 5.2 4.6 5.8 4.5 2.3 31.8 25.6 77.1 35.5 30.5 24.0 22.0 21.2 22.0 25.3 USP35 KIAA1372 ENSG00000118369 "Ubiquitin specific peptidase 35" Q9P2H5 11 78188812-78214711 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "parathyroid gland: 32.4" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Cell type enriched" "Detected in single" 5 "eosinophil: 3.4" "Lineage enriched" "Detected in single" 5 "granulocytes: 3.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA055213, HPA058592" Uncertain Approved "Nucleoplasm,Nucleoli fibrillar center" "Nucleoli fibrillar center" Nucleoplasm "HPA055213: , HPA058592: " "unprognostic (6.69e-2)" "unprognostic (1.17e-2)" "unprognostic (1.69e-1)" "unprognostic (6.87e-3)" "unprognostic (3.38e-2)" "unprognostic (1.08e-2)" "unprognostic (2.00e-1)" "unprognostic (1.46e-1)" "unprognostic (3.57e-2)" "unprognostic (3.84e-3)" "unprognostic (1.03e-2)" "unprognostic (3.11e-2)" "unprognostic (1.29e-3)" "unprognostic (2.93e-1)" "unprognostic (1.31e-1)" "unprognostic (4.38e-2)" "unprognostic (1.49e-2)" 4.9 17.1 5.1 5.4 9.3 3.8 5.2 10.4 15.0 6.4 5.8 8.0 6.3 5.5 6.8 5.4 5.6 5.4 5.6 8.7 6.1 6.7 5.0 13.8 5.6 4.8 6.7 8.8 6.6 6.4 32.4 12.0 7.1 15.0 5.0 3.4 7.7 4.0 5.6 5.6 3.2 5.3 7.8 4.5 4.6 3.9 5.3 4.0 1.9 7.7 2.9 4.1 5.2 6.6 0.0 0.1 3.4 0.6 0.1 0.3 0.2 2.1 3.3 5.7 6.0 9.8 9.0 3.9 4.9 5.8 5.8 4.1 8.3 4.6 1.7 5.1 9.2 5.7 3.8 7.6 3.4 12.2 2.0 2.8 8.6 4.8 7.6 1.8 8.3 7.6 5.1 12.1 3.5 7.1 3.9 4.2 4.5 1.9 4.6 7.2 1.7 5.3 2.8 5.3 2.1 4.6 3.9 2.8 5.4 3.8 5.0 1.8 4.2 1.5 8.6 10.7 6.1 12.6 2.6 5.7 1.9 2.6 3.2 1.9 6.2 0.0 0.2 3.4 0.1 0.6 0.0 0.0 0.2 0.2 0.1 0.0 0.3 0.0 0.2 0.1 0.1 0.1 0.1 0.2 5.1 9.3 10.4 15.0 6.1 6.7 6.7 8.8 15.0 4.0 USP36 "FLJ12851, KIAA1453" ENSG00000055483 "Ubiquitin specific peptidase 36" Q9P275 17 78787381-78841441 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA012082, HPA012395, HPA052860" Uncertain Supported Enhanced "Nucleoli,Nuclear speckles" Nucleoli "Nuclear speckles" "HPA012082: AB_1858682, HPA012395: , HPA052860: " "unprognostic (1.94e-2)" "unprognostic (2.80e-2)" "unprognostic (1.07e-1)" "prognostic unfavourable (5.18e-5)" "unprognostic (9.35e-2)" "unprognostic (1.98e-1)" "unprognostic (2.50e-3)" "unprognostic (1.35e-1)" "unprognostic (2.04e-1)" "unprognostic (1.33e-1)" "unprognostic (1.68e-2)" "unprognostic (2.78e-2)" "unprognostic (1.31e-2)" "unprognostic (1.45e-1)" "unprognostic (1.81e-1)" "unprognostic (4.03e-3)" "unprognostic (1.78e-1)" 26.3 23.4 12.9 21.3 16.0 36.5 28.1 28.3 17.4 17.2 16.4 25.4 19.2 12.3 25.1 22.2 14.6 18.0 21.9 17.4 10.4 11.2 15.9 16.4 20.0 17.2 17.5 16.0 41.3 33.6 19.6 30.0 23.4 14.6 21.0 15.1 20.4 21.8 45.5 19.5 29.3 15.1 25.2 14.5 18.2 17.3 20.8 13.7 12.8 19.3 11.2 22.2 24.6 18.1 6.7 12.4 8.9 5.3 5.6 8.8 2.5 15.7 19.1 5.6 10.4 12.1 13.5 10.8 13.0 13.2 12.5 8.4 18.5 8.0 20.2 6.6 11.5 11.6 13.2 9.6 22.4 4.8 20.0 18.4 27.8 19.2 12.4 20.1 10.1 11.7 16.0 17.8 39.9 10.8 14.6 21.3 10.3 12.1 18.3 20.4 8.7 15.3 14.1 12.3 13.5 7.9 16.6 16.6 10.1 9.3 43.5 23.6 11.2 12.8 9.2 29.5 13.7 17.1 22.9 15.8 6.2 24.8 11.6 15.8 9.2 8.9 3.9 3.1 7.6 5.3 8.8 6.4 7.2 6.4 2.3 6.7 8.0 7.7 5.7 5.6 3.3 12.4 4.8 2.5 12.9 16.0 28.3 17.4 10.4 11.2 17.5 16.0 14.6 13.7 USP37 KIAA1594 ENSG00000135913 "Ubiquitin specific peptidase 37" Q86T82 2 218450251-218568361 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Cell cycle, Cell division, Mitosis, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA045160 Approved Approved Nucleoplasm,Nucleoli "Nucleoplasm, Nucleoli" "HPA045160: AB_10795620" "unprognostic (7.00e-2)" "unprognostic (2.29e-1)" "unprognostic (8.83e-2)" "unprognostic (9.19e-4)" "unprognostic (1.83e-1)" "prognostic favourable (2.85e-4)" "unprognostic (2.18e-2)" "unprognostic (1.14e-1)" "unprognostic (9.66e-3)" "unprognostic (1.17e-1)" "unprognostic (3.78e-3)" "unprognostic (1.11e-1)" "unprognostic (3.82e-2)" "unprognostic (3.26e-1)" "unprognostic (2.87e-1)" "unprognostic (6.69e-2)" "unprognostic (6.41e-3)" 10.4 8.4 9.2 9.7 10.5 19.2 9.0 16.2 10.0 8.3 6.6 10.4 8.0 5.8 9.6 15.8 8.2 7.8 7.0 6.9 7.4 5.5 6.1 7.4 8.1 10.5 8.7 7.8 15.3 6.9 10.7 17.1 8.5 8.7 7.3 7.0 7.4 9.7 9.6 11.1 9.9 7.2 8.1 10.2 7.0 6.6 22.2 10.5 13.4 9.8 5.4 9.4 10.5 9.1 7.4 6.1 7.4 4.8 5.9 9.0 2.5 7.3 5.4 11.4 8.8 3.0 3.7 9.7 5.6 4.1 9.9 11.1 10.2 5.9 6.7 6.2 4.4 7.1 12.5 6.3 10.9 9.2 6.6 18.2 10.9 6.7 3.4 11.8 9.1 2.0 3.8 10.3 7.5 4.2 13.1 13.0 6.2 5.5 15.2 8.1 9.8 4.7 12.3 17.1 6.2 3.4 8.8 12.5 6.8 9.0 4.5 5.7 5.2 8.4 5.3 11.1 9.8 6.2 7.4 8.9 7.8 13.8 6.0 8.8 7.5 6.5 4.2 7.4 7.0 4.8 7.3 5.4 5.8 5.9 4.4 7.4 9.0 5.7 3.5 5.9 4.4 6.1 7.3 2.5 9.2 10.5 16.2 10.0 7.4 5.5 8.7 7.8 8.7 10.5 USP38 "HP43.8KD, KIAA1891" ENSG00000170185 "Ubiquitin specific peptidase 38" Q8NB14 4 143184917-143223830 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 45.3" "Cell line enhanced" "Detected in all" "U-266/84: 35.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA036990, HPA047948" Uncertain Approved Nucleoplasm,Centrosome,Cytosol Nucleoplasm "Centrosome, Cytosol" "HPA036990: , HPA047948: AB_2680220" "unprognostic (5.01e-2)" "unprognostic (2.45e-1)" "unprognostic (2.04e-3)" "unprognostic (2.99e-2)" "unprognostic (1.87e-1)" "unprognostic (2.61e-2)" "unprognostic (1.67e-1)" "unprognostic (7.49e-2)" "unprognostic (3.66e-2)" "unprognostic (3.97e-2)" "unprognostic (8.03e-2)" "unprognostic (7.72e-3)" "prognostic favourable (1.20e-4)" "unprognostic (3.15e-1)" "unprognostic (1.26e-1)" "unprognostic (1.29e-1)" "unprognostic (1.02e-1)" 7.7 7.8 6.6 6.6 6.5 19.1 8.3 7.4 7.8 7.9 12.1 8.6 8.8 8.8 8.3 7.1 8.6 7.1 7.6 12.5 6.6 5.3 9.3 15.2 12.7 11.1 10.3 5.1 6.3 8.8 10.0 6.2 11.4 5.9 6.6 6.6 7.1 7.2 7.0 45.3 8.9 13.2 6.5 10.8 10.6 7.4 7.5 8.2 22.6 8.6 10.2 8.4 7.8 8.8 6.3 8.1 12.5 5.7 12.3 9.9 5.0 4.7 4.5 4.0 6.8 5.2 5.2 2.9 7.6 7.4 7.0 6.0 12.9 7.0 5.9 5.4 6.4 3.8 9.3 7.5 5.8 14.4 6.0 5.4 5.3 2.7 7.2 10.9 5.4 6.3 6.9 7.2 5.8 7.0 11.7 18.5 4.7 7.5 14.2 2.0 3.6 8.7 9.4 5.9 5.6 4.5 5.5 8.1 7.3 5.9 10.3 6.6 6.3 4.1 8.3 6.5 5.3 5.6 7.9 20.7 35.1 10.7 6.6 8.4 5.4 12.5 5.4 11.7 7.5 5.7 9.6 6.3 6.6 6.5 8.1 5.7 6.7 5.7 5.4 12.3 5.7 3.5 9.9 5.0 6.6 6.5 7.4 7.7 6.6 5.3 10.3 5.1 5.9 8.2 USP39 "CGI-21, SAD1, SNRNP65" ENSG00000168883 "Ubiquitin specific peptidase 39" Q53GS9 2 85602856-85649282 "Enzymes, Predicted intracellular proteins" "Cell cycle, Cell division, mRNA processing, mRNA splicing" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA034823, HPA077350" Supported Supported Supported Nucleoplasm Nucleoplasm "HPA034823: AB_10602488, HPA077350: " "unprognostic (1.10e-2)" "unprognostic (3.31e-3)" "unprognostic (1.83e-1)" "prognostic unfavourable (5.52e-4)" "unprognostic (8.46e-3)" "unprognostic (3.67e-2)" "prognostic unfavourable (2.84e-6)" "unprognostic (1.10e-2)" "unprognostic (1.69e-1)" "unprognostic (1.89e-1)" "unprognostic (5.17e-3)" "unprognostic (3.14e-2)" "prognostic unfavourable (4.05e-7)" "unprognostic (3.95e-3)" "unprognostic (2.25e-1)" "unprognostic (2.52e-2)" "unprognostic (2.52e-1)" 19.0 15.1 14.5 23.5 16.8 30.4 18.3 14.9 20.8 20.2 24.1 18.7 11.8 14.7 22.1 24.1 20.7 16.8 20.6 25.5 13.7 13.7 17.8 20.8 18.5 20.8 15.2 14.5 19.2 15.0 17.7 13.7 28.0 15.8 21.6 20.5 18.0 17.2 20.0 44.2 20.2 17.8 19.0 15.0 21.0 18.1 17.2 13.0 56.5 24.7 23.9 27.0 23.0 26.0 25.3 28.8 29.8 29.7 26.4 37.3 28.2 21.7 22.2 22.7 24.9 16.5 13.0 25.5 18.4 17.4 27.4 24.5 35.4 15.8 25.8 17.4 17.3 15.7 43.4 19.8 34.9 25.9 27.6 32.0 13.3 31.2 16.3 38.8 21.9 9.1 15.9 21.1 19.0 21.8 39.2 15.2 20.1 25.3 38.2 29.2 30.0 20.6 35.3 48.7 19.5 14.7 17.0 20.9 17.0 11.5 18.9 15.8 12.7 19.0 13.9 17.0 21.2 20.2 30.4 13.5 24.9 27.6 14.5 41.0 20.3 28.0 25.5 29.8 30.3 29.7 35.2 24.3 31.8 31.2 28.8 25.3 31.4 28.5 16.4 26.4 26.9 22.5 37.3 28.2 14.5 16.8 14.9 20.8 13.7 13.7 15.2 14.5 15.8 13.0 USP4 "UNP, Unph" ENSG00000114316 "Ubiquitin specific peptidase 4" Q13107 3 49277831-49340712 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" Proto-oncogene "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA018499 Approved Supported "Plasma membrane,Cytosol" "Plasma membrane, Cytosol" "HPA018499: AB_1858689" "unprognostic (2.34e-3)" "unprognostic (1.52e-1)" "unprognostic (2.22e-3)" "unprognostic (6.12e-2)" "unprognostic (3.51e-1)" "unprognostic (4.33e-2)" "unprognostic (9.42e-2)" "prognostic favourable (4.46e-5)" "unprognostic (3.54e-1)" "unprognostic (9.07e-3)" "unprognostic (2.78e-2)" "unprognostic (1.70e-3)" "prognostic favourable (4.29e-5)" "unprognostic (7.30e-2)" "unprognostic (1.00e-1)" "unprognostic (1.18e-2)" "unprognostic (1.65e-2)" 22.1 18.4 21.4 22.4 29.3 41.4 23.1 30.3 32.5 20.7 20.1 26.8 16.9 16.1 23.6 20.9 23.5 19.3 17.5 22.8 22.2 18.0 20.2 18.5 25.7 25.5 20.2 17.5 23.6 17.1 23.6 19.7 22.1 24.3 20.9 21.9 23.6 19.1 21.3 25.7 27.6 19.4 25.9 20.4 30.6 17.7 25.0 19.7 36.8 21.2 14.1 42.4 22.1 22.0 17.0 24.1 59.4 27.3 21.5 18.6 22.2 6.2 7.2 10.1 13.4 18.7 20.1 6.8 17.2 15.3 22.3 20.1 7.7 15.9 12.2 6.8 25.0 8.5 13.4 24.4 20.8 18.8 4.0 27.0 14.4 8.5 27.4 14.2 15.6 20.6 10.7 24.4 20.1 25.7 9.4 19.4 20.6 10.7 16.8 24.2 8.5 12.7 6.9 6.3 10.6 17.5 13.1 8.4 11.2 12.5 8.8 6.3 6.1 22.9 22.8 15.0 8.2 18.7 10.0 15.5 7.5 17.8 13.5 22.6 17.2 18.0 27.3 30.0 16.9 22.1 18.6 17.0 17.6 16.9 24.1 14.1 17.1 15.0 59.4 21.5 24.4 9.6 18.6 22.2 21.4 29.3 30.3 32.5 22.2 18.0 20.2 17.5 24.3 19.7 USP40 FLJ10785 ENSG00000085982 "Ubiquitin specific peptidase 40" Q9NVE5 2 233475520-233566782 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA005821 Uncertain Approved Vesicles Vesicles "HPA005821: AB_1080526" "unprognostic (2.19e-1)" "unprognostic (1.04e-1)" "unprognostic (1.13e-1)" "unprognostic (1.33e-1)" "unprognostic (3.70e-1)" "unprognostic (2.15e-1)" "unprognostic (5.30e-2)" "unprognostic (2.25e-1)" "unprognostic (1.80e-2)" "unprognostic (1.18e-1)" "unprognostic (1.96e-1)" "unprognostic (1.26e-1)" "unprognostic (2.22e-1)" "unprognostic (1.45e-1)" "unprognostic (4.09e-2)" "unprognostic (1.90e-2)" "unprognostic (2.53e-2)" 12.5 20.5 11.0 8.2 17.7 3.5 16.1 8.2 13.5 12.4 12.1 26.1 22.5 11.6 16.2 28.1 13.9 13.4 13.2 10.8 11.3 8.5 16.9 15.7 13.9 7.6 22.1 10.1 19.6 17.2 22.8 24.3 16.3 16.5 16.1 11.2 16.4 13.9 19.7 13.6 21.7 15.2 17.1 20.1 11.4 16.3 23.3 18.9 9.8 21.2 9.4 12.0 18.0 11.8 1.9 5.0 0.4 2.8 1.4 2.2 1.4 9.6 11.3 10.4 7.0 15.3 14.3 9.1 9.6 7.4 8.9 9.7 8.0 11.6 0.2 2.8 15.4 17.3 7.9 17.0 12.8 0.0 5.1 7.7 9.3 13.6 13.3 3.2 5.2 13.6 12.3 13.1 18.5 10.2 12.3 1.9 12.5 7.8 3.4 4.7 4.6 9.2 0.0 21.5 4.5 10.6 15.7 5.7 6.2 7.6 7.9 9.8 9.0 7.2 10.1 12.5 7.8 5.2 11.5 3.5 2.6 0.4 16.1 5.8 10.7 0.0 2.7 0.0 1.3 2.8 0.6 1.3 1.5 1.3 4.0 1.9 1.9 2.2 0.4 1.4 2.3 5.0 2.0 1.4 11.0 17.7 8.2 13.5 11.3 8.5 22.1 10.1 16.5 18.9 USP41 ENSG00000161133 "Ubiquitin specific peptidase 41" Q3LFD5 22 20350578-20390758 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Low tissue specificity" "Detected in some" "Cell line enhanced" "Detected in some" "NTERA-2: 1.6;RH-30: 4.1;RT4: 1.7;SCLC-21H: 4.9;SK-BR-3: 1.7;U-937: 1.5" "Not detected" "Not detected" "Low cell type specificity" "Detected in single" "Low lineage specificity" "Detected in single" "unprognostic (4.01e-6)" "unprognostic (1.26e-1)" "unprognostic (1.44e-1)" "unprognostic (4.63e-3)" "unprognostic (7.44e-2)" "unprognostic (1.75e-1)" "unprognostic (5.28e-2)" "unprognostic (4.34e-2)" "unprognostic (3.66e-2)" "unprognostic (9.91e-5)" "unprognostic (3.43e-2)" "unprognostic (3.51e-2)" "unprognostic (2.54e-2)" "unprognostic (4.98e-2)" "unprognostic (1.40e-1)" "unprognostic (4.63e-1)" 0.7 0.3 0.4 0.0 0.6 1.0 0.6 0.0 1.8 0.3 0.3 1.6 0.2 0.0 0.2 0.2 0.0 0.1 0.4 0.4 0.1 0.9 1.3 0.1 0.2 0.1 0.2 0.0 0.4 0.1 0.4 0.2 0.5 0.0 0.7 0.1 0.3 0.0 0.3 0.3 2.0 0.3 0.4 0.3 0.3 0.1 0.4 1.2 0.3 0.4 0.4 0.5 0.1 0.0 0.0 0.3 0.7 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.9 0.0 1.6 0.4 0.0 4.1 0.0 0.0 1.7 4.9 0.2 0.0 1.7 0.0 0.2 0.0 0.0 0.0 0.1 0.3 0.0 0.0 0.1 0.8 1.2 1.5 0.3 0.0 0.0 0.3 0.2 0.2 0.4 0.4 0.1 0.5 0.1 0.2 0.0 0.2 0.0 0.4 0.4 1.2 0.4 0.1 USP42 FLJ12697 ENSG00000106346 "Ubiquitin specific peptidase 42" Q9H9J4 7 6104884-6161564 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Differentiation, Spermatogenesis, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA064800 Approved Nucleoplasm Nucleoplasm "HPA064800: " "unprognostic (1.48e-2)" "unprognostic (1.47e-1)" "unprognostic (2.59e-1)" "unprognostic (1.69e-1)" "unprognostic (1.30e-2)" "unprognostic (1.53e-1)" "unprognostic (1.19e-2)" "unprognostic (3.32e-1)" "unprognostic (1.05e-1)" "unprognostic (2.82e-1)" "unprognostic (6.21e-3)" "unprognostic (2.47e-2)" "unprognostic (3.17e-3)" "unprognostic (3.14e-2)" "unprognostic (3.06e-2)" "unprognostic (2.19e-2)" "unprognostic (2.66e-1)" 6.7 5.6 5.7 5.7 9.5 19.8 7.2 14.1 10.6 8.5 7.4 10.4 5.5 8.1 14.1 7.0 6.9 8.1 6.5 5.4 5.8 6.0 7.4 7.1 7.3 6.5 6.7 4.9 10.6 11.7 10.5 10.9 8.2 6.2 7.4 6.5 8.9 6.6 6.3 7.4 9.2 9.2 8.7 9.9 7.8 6.7 25.2 8.1 14.3 7.7 6.2 8.3 7.6 6.9 1.9 2.2 3.3 2.4 1.9 4.3 0.8 8.3 6.2 11.3 11.0 6.5 5.0 7.7 4.5 5.8 5.4 5.3 4.4 4.4 9.9 3.0 5.6 7.8 9.4 5.0 5.8 2.4 7.3 4.6 5.3 4.5 5.5 10.6 5.3 5.8 5.9 5.7 7.4 6.5 17.6 6.7 3.5 7.4 6.4 12.0 12.7 4.8 12.2 8.8 6.8 5.0 4.4 8.6 15.3 5.8 12.0 3.6 5.5 5.5 5.5 4.8 17.8 6.0 5.4 6.0 5.0 8.6 4.0 6.5 9.4 2.3 1.1 3.3 2.1 2.4 3.0 1.9 2.6 1.3 1.1 1.1 1.7 4.3 1.4 1.9 1.2 2.2 1.8 0.8 5.7 9.5 14.1 10.6 5.8 6.0 6.7 4.9 6.2 8.1 USP43 FLJ30626 ENSG00000154914 "Ubiquitin specific peptidase 43" Q70EL4 17 9644698-9729691 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "placenta: 61.6" "Cell line enhanced" "Detected in many" "BEWO: 12.3;SK-BR-3: 8.5;T-47d: 10.2" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Cell type enhanced" "Detected in single" "NK-cell: 1.1" "Low lineage specificity" "Detected in single" "Low region specificity" "Detected in some" "Low region specificity" "Detected in many" "HPA023389, HPA027762" Uncertain "HPA023389: AB_1858691, HPA027762: AB_10603001" "unprognostic (1.39e-1)" "unprognostic (1.75e-2)" "unprognostic (1.07e-1)" "unprognostic (2.30e-3)" "unprognostic (1.08e-1)" "unprognostic (5.24e-2)" "unprognostic (2.04e-1)" "unprognostic (6.40e-3)" "unprognostic (2.26e-1)" "unprognostic (3.05e-3)" "unprognostic (2.41e-2)" "unprognostic (7.49e-2)" "unprognostic (5.95e-2)" "prognostic favourable (5.39e-4)" "unprognostic (3.24e-1)" "unprognostic (2.06e-1)" "unprognostic (3.28e-1)" 0.2 0.2 4.2 1.2 3.4 0.9 3.0 0.7 6.0 4.9 10.0 0.6 15.7 6.2 2.9 1.7 6.7 6.3 5.1 0.2 4.1 3.8 3.7 8.7 3.4 0.2 1.7 3.1 1.0 7.7 1.7 3.7 61.6 0.7 10.8 5.0 0.3 11.3 12.4 0.2 2.4 12.5 0.3 1.0 0.2 2.6 2.9 0.2 0.4 1.7 4.2 2.7 1.3 2.1 0.0 0.5 0.0 0.0 1.1 0.1 0.1 5.6 1.4 0.0 0.6 0.0 0.0 12.3 0.1 0.2 0.6 1.7 2.8 4.6 0.0 1.9 0.2 6.9 0.6 5.4 0.6 3.6 1.9 0.3 2.9 1.0 0.1 0.5 0.0 0.0 7.1 0.3 3.0 0.0 0.0 0.0 0.0 2.6 0.9 4.6 0.7 0.3 3.7 0.0 0.8 4.3 3.1 0.7 0.0 2.4 8.5 1.0 10.2 1.4 0.0 0.0 1.7 0.0 0.0 0.0 0.0 0.0 0.8 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.1 4.2 3.4 0.7 6.0 4.1 3.8 1.7 3.1 0.7 0.2 USP44 FLJ14528 ENSG00000136014 "Ubiquitin specific peptidase 44" Q9H0E7 12 95516560-95551490 "Enzymes, Predicted intracellular proteins" "Cell cycle, Cell division, Mitosis, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "testis: 26.8" "Cell line enriched" "Detected in some" 5 "NTERA-2: 54.8" "Cancer enhanced" "Detected in some" "testis cancer: 3.0" "Region enriched" "Detected in many" 5 "cerebellum: 10.9" "Cell type enhanced" "Detected in many" "naive CD4 T-cell: 8.6" "Group enriched" "Detected in many" 39 "B-cells: 5.6;T-cells: 8.6" "Low region specificity" "Detected in all" HPA026543 Approved "Nucleoli fibrillar center,Microtubules" "Nucleoli fibrillar center, Microtubules" "HPA026543: AB_1858692" "unprognostic (2.12e-2)" "unprognostic (1.14e-1)" "unprognostic (4.68e-2)" "unprognostic (1.01e-3)" "unprognostic (1.83e-4)" "unprognostic (7.18e-4)" "unprognostic (5.55e-2)" "unprognostic (1.85e-2)" "unprognostic (2.16e-1)" "unprognostic (3.73e-2)" "unprognostic (6.88e-2)" "unprognostic (2.97e-2)" "unprognostic (8.12e-2)" "unprognostic (1.41e-2)" "unprognostic (1.08e-1)" "unprognostic (7.41e-2)" "unprognostic (7.07e-2)" 1.3 1.0 0.7 1.2 1.3 0.5 1.4 10.9 2.1 1.7 1.7 1.7 1.4 0.5 3.0 1.0 0.9 1.6 1.1 1.0 0.7 0.6 1.9 0.2 4.7 1.9 1.3 1.2 1.6 3.6 4.8 4.0 0.3 1.8 1.7 0.6 2.3 1.8 2.6 0.4 0.6 1.3 1.2 0.6 1.9 1.0 26.8 1.2 0.8 1.7 0.0 1.6 1.1 2.3 5.6 0.1 0.1 0.0 0.1 8.6 1.3 0.0 0.1 4.5 0.0 0.0 0.0 0.1 0.4 1.3 0.5 0.2 0.0 0.0 0.0 1.3 0.0 0.0 0.0 0.0 0.7 0.0 2.2 10.1 0.0 0.0 2.4 4.1 0.2 0.0 0.0 0.3 0.0 0.2 1.6 0.0 0.0 0.0 5.2 0.0 54.8 0.0 0.0 0.0 0.0 0.9 0.3 3.5 2.3 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.1 1.8 0.0 0.3 0.1 0.0 0.0 0.0 1.5 0.0 3.4 5.6 2.3 2.0 0.0 4.4 8.6 5.5 0.1 0.1 0.0 0.1 0.3 1.3 0.7 1.3 10.9 2.1 0.7 0.6 1.3 1.2 1.8 1.2 USP45 MGC14793 ENSG00000123552 "Ubiquitin specific peptidase 45" Q70EL2 6 99432379-99521728 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA029602, HPA029604" Uncertain Approved Nucleoplasm,Cytosol "Nucleoplasm, Cytosol" "HPA029602: AB_10600418, HPA029604: AB_10602283" "unprognostic (7.81e-3)" "unprognostic (3.10e-3)" "unprognostic (1.63e-2)" "unprognostic (6.62e-2)" "unprognostic (1.02e-2)" "unprognostic (1.92e-1)" "unprognostic (2.15e-2)" "unprognostic (1.01e-1)" "unprognostic (2.77e-2)" "unprognostic (8.65e-2)" "unprognostic (2.95e-3)" "unprognostic (1.10e-1)" "unprognostic (3.43e-3)" "unprognostic (1.13e-1)" "unprognostic (3.53e-1)" "unprognostic (1.43e-1)" "unprognostic (6.91e-2)" 9.8 9.1 8.5 10.2 12.2 7.2 9.0 28.4 11.6 9.0 9.7 8.6 8.9 13.7 15.7 9.6 10.0 8.1 11.9 11.5 7.7 8.5 12.2 9.0 7.1 12.7 9.8 8.0 10.7 9.6 10.2 21.7 9.6 15.0 9.9 13.1 7.9 9.8 8.4 14.6 11.8 12.4 10.8 10.6 9.9 8.9 5.7 9.4 7.1 10.7 10.4 9.5 8.8 15.0 8.6 5.1 3.7 2.5 2.6 6.2 1.4 4.1 3.0 5.9 8.3 10.9 10.4 6.2 7.2 8.1 7.6 10.8 6.1 4.6 11.1 5.4 7.3 5.6 9.0 7.2 10.5 8.7 8.6 10.8 5.9 4.8 8.4 10.0 6.2 11.1 5.7 6.8 11.6 11.2 26.0 11.0 7.1 3.9 3.2 9.5 9.5 6.4 4.7 4.4 6.2 10.5 4.9 8.3 6.8 5.1 6.8 5.3 3.6 4.9 11.2 4.2 5.3 6.1 11.0 4.7 4.3 20.3 7.2 9.5 7.4 3.7 2.0 0.6 4.9 1.3 6.2 7.4 4.2 5.6 3.5 8.6 3.0 2.9 0.5 2.6 2.5 5.1 3.5 1.4 8.5 12.2 28.4 11.6 7.7 8.5 9.8 8.0 15.0 9.4 USP46 FLJ12552 ENSG00000109189 "Ubiquitin specific peptidase 46" P62068 4 52590972-52659335 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Behavior, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA007288, CAB076369, CAB076370" Uncertain Approved Nucleoli Nucleoli "CAB076369: , CAB076370: , HPA007288: AB_1080531" "unprognostic (1.15e-2)" "unprognostic (1.64e-1)" "unprognostic (1.19e-1)" "unprognostic (1.61e-2)" "unprognostic (1.31e-1)" "unprognostic (1.41e-1)" "unprognostic (1.53e-3)" "unprognostic (1.59e-1)" "unprognostic (2.45e-2)" "unprognostic (1.80e-2)" "unprognostic (2.89e-1)" "unprognostic (1.95e-1)" "unprognostic (1.05e-1)" "unprognostic (1.45e-1)" "unprognostic (3.95e-2)" "unprognostic (2.02e-2)" "unprognostic (1.28e-1)" 4.7 9.5 26.0 3.5 20.9 2.8 7.0 23.7 29.4 8.9 4.2 12.8 5.2 4.8 7.2 6.2 12.4 7.8 5.8 28.9 21.9 19.0 10.8 3.1 4.4 3.7 19.1 13.9 12.3 5.6 12.2 5.3 10.6 12.7 7.7 4.6 5.3 8.0 7.8 13.7 8.0 4.5 5.5 18.9 3.5 6.3 12.2 15.0 1.0 10.0 4.3 5.8 7.3 5.7 1.4 4.4 2.0 1.4 1.2 3.9 1.0 5.3 3.8 12.3 9.1 13.5 16.9 13.6 8.8 7.1 6.5 5.5 7.6 4.2 3.5 10.4 8.7 3.1 21.4 10.2 12.0 3.1 7.5 5.5 3.6 8.5 13.5 7.3 6.5 14.4 9.6 6.7 6.3 9.6 5.4 5.0 13.8 4.9 3.1 3.8 9.1 4.6 7.9 9.0 0.7 14.0 9.9 7.4 8.9 4.3 14.7 8.5 5.4 5.5 8.9 6.4 14.0 7.5 13.2 5.2 2.4 2.8 9.9 4.4 7.9 2.0 1.4 0.3 2.3 1.2 1.7 1.4 3.9 2.0 2.8 1.2 0.9 0.8 0.3 1.2 0.9 4.4 1.2 1.0 26.0 20.9 23.7 24.3 21.9 19.0 19.1 13.9 12.7 15.0 USP47 ENSG00000170242 "Ubiquitin specific peptidase 47" Q96K76 11 11841423-11959323 "Enzymes, Predicted intracellular proteins" "DNA damage, DNA repair, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA029286, HPA029289" Supported "HPA029286: AB_10599852, HPA029289: AB_10601675" "unprognostic (2.02e-1)" "unprognostic (2.72e-1)" "unprognostic (3.05e-1)" "unprognostic (1.84e-1)" "unprognostic (2.99e-2)" "unprognostic (2.65e-2)" "unprognostic (2.27e-2)" "unprognostic (7.39e-2)" "unprognostic (1.54e-2)" "unprognostic (7.05e-2)" "unprognostic (2.83e-2)" "unprognostic (2.35e-1)" "unprognostic (1.51e-1)" "unprognostic (9.96e-3)" "unprognostic (1.90e-1)" "unprognostic (1.49e-1)" "unprognostic (2.85e-1)" 16.6 17.0 17.9 18.5 20.9 20.3 16.9 25.7 19.0 16.4 18.1 16.2 21.3 11.6 18.0 15.0 18.7 13.7 13.5 25.5 18.1 13.4 14.6 25.1 16.6 13.4 21.9 12.9 16.9 19.6 38.8 31.8 23.7 19.3 18.0 14.2 10.2 15.1 19.2 58.1 18.4 15.1 21.3 19.5 13.3 18.1 16.8 23.9 27.9 16.8 12.4 15.2 21.3 19.4 9.7 10.1 14.0 13.2 22.8 19.3 9.7 21.0 12.8 23.1 10.9 16.7 18.4 10.6 24.2 18.3 16.0 18.1 12.6 18.8 23.8 11.5 22.5 14.4 17.8 12.1 24.7 23.2 15.0 14.3 23.8 8.9 14.8 18.5 20.1 17.1 16.7 10.5 23.3 17.8 28.5 20.6 19.5 8.3 16.7 8.2 6.2 10.4 17.2 24.3 7.4 17.2 24.4 8.0 16.4 21.6 15.1 13.4 12.1 13.6 19.6 22.7 13.8 19.3 14.7 6.5 14.9 22.6 15.6 11.4 16.2 13.3 7.7 14.0 15.2 9.5 19.3 9.7 13.8 14.7 10.1 8.6 17.9 15.3 3.6 22.8 13.2 6.1 9.9 9.7 17.9 20.9 25.7 19.0 18.1 13.4 21.9 12.9 19.3 23.9 USP48 "FLJ11328, FLJ20103, FLJ23054, FLJ23277, MGC14879, USP31" ENSG00000090686 "Ubiquitin specific peptidase 48" Q86UV5 1 21678298-21783606 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA030045, HPA030046" Approved Supported Nucleoplasm,Mitochondria,Cytosol Nucleoplasm "Mitochondria, Cytosol" "HPA030045: AB_10670833, HPA030046: AB_10603325" "unprognostic (1.35e-1)" "unprognostic (3.72e-1)" "unprognostic (5.46e-3)" "unprognostic (2.21e-1)" "unprognostic (1.23e-1)" "unprognostic (7.00e-3)" "prognostic unfavourable (6.09e-8)" "unprognostic (1.04e-2)" "unprognostic (3.01e-3)" "unprognostic (9.30e-2)" "unprognostic (7.54e-2)" "unprognostic (4.45e-2)" "unprognostic (4.16e-3)" "unprognostic (2.03e-1)" "unprognostic (1.06e-1)" "unprognostic (5.70e-2)" "unprognostic (2.80e-2)" 20.1 38.8 18.6 28.9 30.9 30.9 22.1 48.2 27.5 19.9 18.4 25.6 15.4 17.6 21.3 17.6 19.0 17.4 20.5 17.8 16.9 15.8 15.5 18.3 18.3 26.2 26.6 22.5 27.0 19.8 24.6 35.4 23.1 26.8 21.6 22.0 22.1 24.5 16.3 17.0 23.9 22.2 22.2 19.7 29.1 26.2 15.8 23.6 25.8 23.9 14.0 29.0 19.8 21.0 13.7 10.5 33.7 9.6 5.6 11.2 5.6 14.6 7.0 16.5 11.9 14.3 17.7 16.3 18.5 12.6 12.4 16.5 6.4 15.0 16.5 12.5 16.7 13.6 20.3 14.9 18.9 16.0 13.9 35.3 26.1 11.6 12.8 17.7 18.9 14.3 12.9 12.6 14.1 36.6 27.7 46.8 15.2 7.3 14.6 23.0 10.4 12.6 20.6 16.6 19.3 14.3 12.4 20.1 12.5 17.4 16.0 41.8 8.2 21.4 25.9 13.4 11.1 16.4 10.7 37.5 26.6 16.4 12.9 22.0 19.7 33.7 9.6 16.7 6.4 4.6 7.6 13.7 9.5 9.5 10.5 12.8 11.2 7.0 8.9 5.6 5.0 7.7 10.1 5.6 18.6 30.9 48.2 27.5 16.9 15.8 26.6 22.5 26.8 23.6 USP49 MGC20741 ENSG00000164663 "Ubiquitin specific peptidase 49" Q70CQ1 6 41789896-41895361 "Enzymes, Plasma proteins, Predicted intracellular proteins" "mRNA processing, mRNA splicing, Ubl conjugation pathway" "Chromatin regulator, Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell line enhanced" "Detected in many" "REH: 23.4;U-698: 33.3" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Cell type enhanced" "Detected in many" "basophil: 8.5" "Lineage enriched" "Detected in many" 5 "granulocytes: 8.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA030254, HPA030255" Uncertain "HPA030254: AB_10600198, HPA030255: AB_10601218" "unprognostic (1.71e-1)" "unprognostic (4.86e-3)" "unprognostic (1.93e-1)" "unprognostic (2.57e-4)" "unprognostic (4.46e-2)" "unprognostic (2.84e-4)" "unprognostic (7.17e-3)" "unprognostic (5.06e-2)" "unprognostic (1.19e-2)" "unprognostic (3.22e-1)" "unprognostic (5.59e-3)" "unprognostic (8.28e-2)" "unprognostic (1.26e-5)" "unprognostic (5.39e-2)" "unprognostic (4.58e-2)" "unprognostic (4.37e-3)" "unprognostic (3.24e-3)" 2.4 2.4 7.6 3.5 6.0 7.3 2.7 12.7 9.3 2.3 1.9 2.0 4.3 2.2 4.0 2.3 1.8 2.2 2.1 3.5 7.6 4.2 1.6 1.7 2.4 3.7 3.0 5.8 4.0 3.2 2.6 4.8 1.8 4.2 2.4 2.1 3.7 2.7 2.4 3.8 4.1 2.2 3.2 3.2 3.5 2.2 7.4 3.2 7.3 7.7 0.6 3.4 2.8 2.0 1.2 0.7 8.5 1.8 0.8 0.9 0.4 3.0 0.9 12.3 6.0 1.5 1.6 5.1 1.1 1.1 1.8 2.2 3.9 0.7 12.4 1.3 1.5 1.3 7.6 1.1 2.7 3.0 5.6 4.4 4.6 1.3 1.0 3.4 2.7 1.6 0.9 2.6 1.7 1.1 9.2 3.4 1.4 1.7 13.1 5.2 3.4 1.1 23.4 6.0 2.7 0.7 2.1 8.3 3.4 1.6 0.6 0.6 1.8 3.1 3.1 4.3 4.2 1.4 1.5 6.4 5.6 33.3 0.5 3.5 0.8 8.5 1.3 1.4 0.8 1.5 0.4 1.2 0.4 0.8 0.5 0.9 0.9 0.7 2.4 0.8 1.8 0.7 0.4 0.4 7.6 6.0 12.7 9.3 7.6 4.2 3.0 5.8 4.2 3.2 USP5 IsoT ENSG00000111667 "Ubiquitin specific peptidase 5" P45974 12 6852128-6866632 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA006756 Uncertain Approved Nucleoplasm,Cytosol 820000 "Nucleoplasm, Cytosol" "HPA006756: AB_1080534" "unprognostic (2.19e-1)" "unprognostic (5.83e-2)" "unprognostic (2.48e-1)" "unprognostic (2.57e-1)" "unprognostic (7.60e-2)" "unprognostic (2.21e-2)" "unprognostic (4.02e-2)" "unprognostic (3.93e-2)" "unprognostic (2.57e-1)" "unprognostic (4.71e-2)" "unprognostic (8.90e-3)" "unprognostic (4.69e-2)" "unprognostic (1.17e-2)" "unprognostic (2.65e-2)" "unprognostic (3.56e-1)" "unprognostic (3.23e-1)" "unprognostic (2.02e-3)" 18.6 28.7 23.1 17.8 32.6 13.6 12.9 24.6 50.9 15.9 21.5 26.8 13.8 17.6 22.3 12.8 27.7 19.1 14.7 22.4 23.9 28.6 14.9 24.8 14.4 18.6 23.6 33.2 14.4 13.2 29.7 19.6 21.7 36.8 19.5 16.1 11.6 14.1 22.7 41.2 33.5 18.1 25.3 23.6 14.1 15.9 30.9 18.7 22.8 19.2 20.4 19.9 21.3 16.0 10.8 18.6 5.3 16.6 10.8 17.1 16.6 25.3 39.7 26.7 30.2 18.2 16.8 34.1 27.6 21.2 33.0 24.1 37.5 25.2 30.7 14.5 28.6 22.4 29.3 27.4 21.2 57.5 24.8 28.1 31.9 20.3 14.2 25.4 29.6 16.9 15.9 28.5 19.8 28.2 24.1 12.3 27.2 27.8 38.1 12.6 52.0 16.8 30.0 34.8 21.2 18.8 24.7 14.7 29.7 18.8 28.7 12.0 11.5 20.8 27.3 28.0 33.9 21.3 34.3 14.9 34.2 46.7 31.2 16.2 27.2 2.3 12.3 5.3 17.1 16.6 16.1 10.8 15.2 14.4 18.6 10.0 14.6 14.8 0.9 10.8 14.7 13.6 12.9 16.6 23.1 32.6 24.6 50.9 23.9 28.6 23.6 33.2 36.8 18.7 USP50 ENSG00000170236 "Ubiquitin specific peptidase 50" Q70EL3 15 50500562-50546708 "Enzymes, Predicted intracellular proteins" "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Tissue enriched" "Detected in some" 15 "testis: 20.2" "Cell line enhanced" "Detected in some" "HaCaT: 1.2;HEL: 1.1;RH-30: 1.0;SK-BR-3: 1.7;SK-MEL-30: 2.9;U-698: 1.1" "Not detected" "Not detected" "Not detected" "Not detected" "Cell type enhanced" "Detected in single" "plasmacytoid DC: 1.3" "Low lineage specificity" "Detected in single" "Region enriched" "Detected in single" 9 "hippocampal formation: 0.4" "Low region specificity" "Detected in single" HPA039470 Uncertain "HPA039470: AB_10672964" "unprognostic (7.05e-3)" "unprognostic (2.38e-1)" "unprognostic (2.01e-2)" "unprognostic (4.04e-3)" "unprognostic (3.37e-1)" "unprognostic (2.53e-2)" "unprognostic (3.95e-2)" "unprognostic (1.73e-2)" "unprognostic (1.51e-1)" "unprognostic (1.42e-1)" "unprognostic (1.85e-1)" "unprognostic (3.81e-2)" "unprognostic (4.65e-2)" "unprognostic (2.47e-1)" "unprognostic (7.49e-4)" "unprognostic (3.03e-1)" 0.1 0.2 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 20.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.3 0.0 0.0 0.0 0.8 0.0 0.3 0.0 0.3 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.2 0.0 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.3 0.0 0.0 0.2 1.7 2.9 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.5 0.6 1.1 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.3 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USP51 ENSG00000247746 "Ubiquitin specific peptidase 51" Q70EK9 X 55484616-55489202 "Enzymes, Predicted intracellular proteins" "DNA damage, DNA repair, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 8 "epididymis: 34.1" "Low cell line specificity" "Detected in many" "Low cancer specificity" "Detected in many" "Cell type enhanced" "Detected in some" "eosinophil: 2.4;naive CD4 T-cell: 2.4" "Low lineage specificity" "Detected in many" "Low region specificity" "Detected in some" "Low region specificity" "Detected in all" HPA001942 Uncertain Approved "Nucleoli fibrillar center,Cytosol" Cytosol "Nucleoli fibrillar center" "HPA001942: AB_1080536" "unprognostic (1.19e-2)" "unprognostic (4.65e-2)" "unprognostic (3.67e-2)" "unprognostic (1.02e-3)" "unprognostic (8.08e-2)" "unprognostic (3.26e-1)" "unprognostic (3.17e-3)" "unprognostic (2.07e-3)" "unprognostic (5.69e-2)" "prognostic favourable (5.70e-4)" "unprognostic (1.01e-3)" "unprognostic (1.27e-1)" "prognostic favourable (2.63e-5)" "unprognostic (2.81e-3)" "unprognostic (5.92e-2)" "unprognostic (5.85e-2)" "unprognostic (1.63e-1)" 0.6 2.7 2.0 0.3 2.9 0.1 0.9 2.3 1.8 1.4 0.6 0.0 1.8 34.1 0.2 3.4 0.3 1.0 1.8 3.7 2.2 0.5 0.7 0.4 1.6 4.1 0.8 3.6 1.8 1.3 1.3 0.3 0.3 1.5 0.0 0.5 0.5 1.1 1.4 0.9 0.3 1.3 3.2 0.5 0.7 0.5 0.9 0.0 2.4 0.0 0.6 2.4 0.1 0.0 0.9 5.7 1.7 2.9 1.5 0.0 0.9 0.5 1.1 1.3 1.8 0.8 0.0 6.9 1.2 0.3 1.5 0.6 1.8 1.8 0.1 1.5 0.3 0.0 1.2 3.5 0.3 5.9 0.1 0.6 0.0 0.4 4.4 4.4 0.9 3.8 3.4 1.8 7.2 0.3 4.9 1.1 2.2 1.4 0.2 0.0 1.1 1.6 0.2 5.4 1.4 1.8 0.3 2.3 3.1 0.6 0.2 7.0 2.7 1.4 1.5 2.0 1.5 0.0 0.0 2.4 0.3 0.0 0.0 0.6 0.6 0.0 0.0 0.9 2.4 0.2 0.0 0.6 0.0 0.0 0.0 0.1 USP53 KIAA1350 ENSG00000145390 "Ubiquitin specific peptidase 53" Q70EK8 4 119212587-119295517 "Enzymes, Predicted intracellular proteins" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell line enhanced" "Detected in many" "BJ hTERT+: 82.1;SK-MEL-30: 25.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA035844, HPA035845" Uncertain Approved "Nucleoplasm,Golgi apparatus" Nucleoplasm "Golgi apparatus" "HPA035844: AB_10669532, HPA035845: " "unprognostic (9.33e-2)" "unprognostic (1.49e-2)" "prognostic favourable (3.15e-6)" "unprognostic (4.37e-3)" "unprognostic (4.82e-2)" "unprognostic (5.03e-2)" "unprognostic (1.55e-1)" "unprognostic (9.54e-2)" "unprognostic (1.77e-1)" "unprognostic (9.81e-3)" "unprognostic (1.28e-1)" "prognostic unfavourable (7.54e-6)" "prognostic favourable (3.58e-8)" "unprognostic (9.02e-2)" "unprognostic (1.72e-1)" "unprognostic (1.58e-1)" "unprognostic (3.70e-2)" 26.7 11.9 4.6 11.2 7.9 0.7 20.7 10.9 6.2 16.5 15.0 2.9 27.4 4.5 11.6 16.1 17.9 24.7 8.2 18.6 6.4 5.3 20.2 6.6 26.1 8.7 8.8 4.0 11.4 19.3 6.2 33.9 10.4 13.4 10.7 13.1 17.2 17.7 25.8 33.7 11.3 11.2 9.0 15.5 14.1 13.6 10.2 4.9 4.8 10.7 15.6 8.0 20.5 27.0 1.9 0.8 3.1 0.0 2.2 5.1 0.9 2.7 1.6 0.6 0.0 15.7 15.8 3.4 17.6 82.1 1.6 2.1 1.8 2.6 11.3 0.6 5.2 1.3 1.3 1.3 4.1 1.4 1.1 0.7 1.2 0.6 12.3 0.9 0.1 5.2 3.8 5.5 8.0 7.4 1.7 0.4 2.1 0.6 0.6 1.2 1.7 0.9 0.2 2.9 2.2 4.1 1.7 0.9 0.7 0.9 6.9 25.4 1.7 0.6 8.0 0.5 1.8 6.6 1.5 0.8 1.2 1.9 8.0 0.4 2.0 3.1 0.0 0.2 1.3 0.0 1.4 1.7 2.6 2.0 0.4 1.9 5.1 2.7 0.6 2.2 0.0 0.8 2.2 0.9 4.6 7.9 10.9 6.2 6.4 5.3 8.8 4.0 13.4 4.9 USP54 "bA137L10.3, bA137L10.4, C10orf29, FLJ37318" ENSG00000166348 "Ubiquitin specific peptidase 54" Q70EL1 10 73497538-73625953 "Enzymes, Predicted intracellular proteins" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 49.5" "Cell line enhanced" "Detected in many" "PC-3: 24.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA047663 Approved Approved Mitochondria Mitochondria "HPA047663: " "unprognostic (2.46e-2)" "unprognostic (1.67e-1)" "unprognostic (3.17e-2)" "unprognostic (1.89e-2)" "unprognostic (2.48e-2)" "unprognostic (4.89e-3)" "unprognostic (6.63e-4)" "prognostic favourable (7.00e-4)" "unprognostic (6.24e-2)" "unprognostic (4.35e-2)" "unprognostic (8.91e-3)" "unprognostic (3.49e-1)" "unprognostic (1.95e-3)" "unprognostic (8.18e-2)" "unprognostic (6.88e-2)" "unprognostic (1.65e-2)" "unprognostic (1.31e-1)" 2.9 1.7 12.3 2.5 33.8 0.5 7.7 7.9 21.3 7.9 7.8 43.8 1.8 2.5 4.2 4.5 10.2 7.7 3.1 4.0 14.1 6.8 2.7 1.6 9.0 0.6 49.5 14.2 4.0 6.3 7.1 3.4 1.2 28.6 5.8 11.1 3.4 8.8 3.6 12.0 6.1 2.9 4.0 25.4 1.5 11.3 4.7 42.8 0.4 24.3 1.2 3.6 5.6 4.0 2.4 2.2 1.3 2.4 1.5 3.2 2.3 6.6 6.8 10.6 10.0 2.9 3.4 3.3 3.5 7.0 5.9 6.9 5.7 10.9 5.0 4.2 3.7 9.2 6.8 2.5 7.9 2.4 6.3 3.1 5.0 3.8 2.3 3.4 1.2 2.6 2.4 6.8 6.9 2.7 4.9 0.7 4.1 3.3 3.3 2.2 4.9 24.9 5.0 9.4 1.9 4.2 6.5 3.5 3.3 6.8 8.3 8.0 10.8 3.2 3.7 2.3 6.9 4.5 4.4 1.8 3.3 3.5 5.6 3.2 2.1 0.8 2.3 1.3 1.6 1.9 3.1 2.4 2.7 2.5 1.9 1.0 3.2 1.9 0.1 1.5 2.4 2.2 3.0 2.3 12.3 33.8 7.9 21.3 14.1 6.8 49.5 14.2 28.6 42.8 USP6 "HRP1, Tre-2, TRE17, Tre2, TRESMCR" ENSG00000129204 "Ubiquitin specific peptidase 6" P35125 17 5116438-5175034 "Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" "Ubl conjugation pathway" "Calmodulin-binding, Hydrolase, Protease, Thiol protease" "Cancer-related genes, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 9 "skeletal muscle: 18.2;testis: 29.0" "Low cell line specificity" "Detected in many" "Cancer enriched" "Detected in single" 14 "testis cancer: 2.8" "Not detected" "Not detected" "Low cell type specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low region specificity" "Detected in all" HPA046969 Uncertain Vesicles Vesicles "HPA046969: " "unprognostic (3.89e-2)" "unprognostic (3.79e-3)" "unprognostic (2.50e-1)" "unprognostic (1.85e-1)" "unprognostic (9.32e-2)" "unprognostic (3.50e-3)" "unprognostic (1.29e-1)" "unprognostic (1.67e-2)" "unprognostic (3.45e-2)" "unprognostic (2.46e-2)" "unprognostic (7.91e-4)" "unprognostic (6.28e-3)" "unprognostic (3.24e-4)" "unprognostic (3.75e-2)" "unprognostic (3.13e-1)" "unprognostic (2.71e-1)" "unprognostic (7.09e-4)" 0.3 0.3 0.3 0.3 0.6 0.2 0.4 0.5 0.5 0.3 0.5 0.3 1.2 0.0 0.6 0.6 0.3 0.5 0.4 0.3 0.3 0.1 0.3 0.3 0.3 0.3 0.3 0.3 2.6 0.3 0.0 0.4 0.4 0.3 0.4 0.1 0.3 0.3 0.3 18.2 0.6 0.7 0.9 0.3 0.3 0.0 29.0 0.3 0.3 0.4 0.3 0.3 0.3 0.3 0.9 1.2 1.9 1.0 0.2 0.4 0.1 2.2 1.0 2.2 1.7 0.4 0.2 2.3 1.9 0.1 0.6 0.4 0.8 1.1 2.2 1.7 1.3 1.0 0.7 0.8 0.5 1.6 1.3 1.7 1.3 0.9 1.2 0.5 2.9 1.1 0.5 0.1 0.2 0.3 0.5 0.3 0.5 2.5 1.9 0.7 1.6 0.1 1.4 2.0 0.2 0.5 0.7 0.9 2.2 1.0 0.1 3.3 2.2 2.2 1.2 1.0 3.3 2.1 1.4 2.0 1.7 1.5 0.0 0.1 2.7 0.1 0.4 0.9 0.4 0.3 0.2 0.6 0.3 0.3 0.3 0.9 0.3 0.4 1.9 0.2 1.0 1.2 0.1 0.1 0.3 0.6 0.5 0.3 0.3 0.1 0.3 0.3 0.3 0.3 USP7 HAUSP ENSG00000187555 "Ubiquitin specific peptidase 7" Q93009 16 8892094-8964514 "Enzymes, Predicted intracellular proteins" "Biological rhythms, DNA damage, DNA repair, Host-virus interaction, Ubl conjugation pathway" "Developmental protein, Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB008108, HPA015641" Approved "CAB008108: AB_2233500, HPA015641: AB_1858700" "unprognostic (6.73e-2)" "unprognostic (1.59e-1)" "unprognostic (3.36e-3)" "unprognostic (1.94e-2)" "unprognostic (9.64e-2)" "unprognostic (8.09e-2)" "unprognostic (4.69e-2)" "unprognostic (4.56e-2)" "unprognostic (4.81e-1)" "unprognostic (2.49e-1)" "unprognostic (2.35e-1)" "unprognostic (9.93e-2)" "prognostic favourable (8.56e-5)" "unprognostic (1.35e-1)" "unprognostic (1.07e-1)" "unprognostic (7.31e-2)" "unprognostic (2.69e-1)" 17.8 16.8 23.9 25.8 22.9 37.6 21.3 28.7 24.5 21.2 26.3 16.2 18.4 17.7 23.5 16.4 24.4 20.3 18.7 23.7 22.8 20.8 16.5 21.3 21.0 30.5 19.6 22.6 22.5 24.0 44.4 19.7 19.3 16.2 18.5 27.4 16.0 18.4 20.3 42.2 25.2 21.5 22.7 15.3 22.9 22.6 43.3 16.5 68.8 19.5 22.3 35.1 23.9 31.7 7.5 9.8 5.5 7.8 3.9 8.7 1.8 12.7 23.7 21.0 15.7 11.9 15.3 14.5 17.6 15.1 16.5 14.0 21.2 15.6 30.7 11.2 20.3 15.9 32.1 21.0 27.6 20.1 12.8 25.5 16.0 43.8 17.3 28.0 16.5 13.2 13.3 17.9 21.2 23.3 24.6 34.1 16.7 24.3 41.1 5.4 14.7 13.8 36.6 23.6 28.0 11.5 25.0 19.8 12.2 19.7 18.5 9.7 18.5 12.6 19.9 17.8 18.2 27.3 13.1 16.5 40.4 47.0 16.6 16.4 14.3 5.5 3.3 3.8 7.1 3.2 8.7 5.9 6.6 8.2 3.3 7.5 8.0 6.8 5.2 3.9 7.8 9.8 7.0 1.8 23.9 22.9 28.7 24.5 22.8 20.8 19.6 22.6 16.2 16.5 USP8 "HumORF8, KIAA0055, SPG59, UBPY" ENSG00000138592 "Ubiquitin specific peptidase 8" P40818 15 50424380-50514419 "Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" "Cell cycle, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Cancer-related genes, Cushing syndrome, Disease mutation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA050215 Approved Supported "Golgi apparatus,Cytosol" "Golgi apparatus" Cytosol "HPA050215: " "unprognostic (5.81e-2)" "unprognostic (1.34e-1)" "unprognostic (1.46e-1)" "unprognostic (9.58e-2)" "unprognostic (2.35e-2)" "unprognostic (2.91e-1)" "unprognostic (1.42e-1)" "unprognostic (3.96e-1)" "unprognostic (1.68e-2)" "unprognostic (5.08e-2)" "unprognostic (2.94e-1)" "unprognostic (3.99e-2)" "prognostic favourable (1.29e-5)" "unprognostic (4.89e-2)" "unprognostic (1.13e-1)" "unprognostic (3.79e-1)" "unprognostic (1.58e-1)" 19.4 21.9 21.0 20.6 20.6 21.6 18.1 27.3 21.6 21.4 23.9 13.8 19.5 20.2 22.1 17.4 22.3 17.4 15.5 17.4 19.7 18.2 28.2 26.4 17.0 25.4 21.8 15.2 21.9 16.7 42.6 43.2 29.1 29.7 16.7 18.9 10.7 19.9 17.9 24.3 17.8 32.1 19.2 29.3 30.3 17.7 27.5 26.1 28.9 24.1 12.7 20.9 22.3 18.4 16.7 10.6 38.1 15.1 9.5 11.9 6.9 11.0 15.9 8.9 15.7 16.3 18.3 12.4 15.9 18.9 15.5 18.4 10.6 7.3 11.7 12.3 18.2 21.5 12.2 11.9 18.4 10.2 8.1 21.6 14.8 10.9 16.8 14.4 14.6 14.2 14.3 13.7 23.3 15.0 12.3 14.2 14.5 22.7 9.2 5.7 10.2 7.3 8.4 16.6 17.5 14.7 26.1 11.4 10.4 16.8 25.1 20.8 13.7 17.7 17.0 16.1 9.1 49.6 21.0 11.1 23.1 12.9 12.9 29.2 15.5 38.1 13.3 22.4 11.1 12.4 10.7 16.5 11.4 11.1 10.6 16.7 11.9 10.7 22.7 9.5 15.1 9.9 8.5 6.9 21.0 20.6 27.3 21.6 19.7 18.2 21.8 15.2 29.7 26.1 USP9X "DFFRX, FAF, MRX99" ENSG00000124486 "Ubiquitin specific peptidase 9, X-linked" Q93008 X 41085635-41236579 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" "Biological rhythms, Cell cycle, Cell division, Chromosome partition, Mitosis, Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Disease mutation, Mental retardation" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB011618, HPA047417, CAB070164" Approved Uncertain Vesicles Vesicles "CAB011618: AB_470860, CAB070164: AB_10011071, HPA047417: " "unprognostic (5.42e-3)" "unprognostic (6.42e-2)" "unprognostic (3.19e-3)" "unprognostic (2.94e-2)" "unprognostic (5.99e-2)" "unprognostic (4.76e-1)" "unprognostic (1.82e-2)" "unprognostic (4.07e-1)" "unprognostic (1.90e-1)" "unprognostic (1.72e-1)" "unprognostic (7.07e-2)" "unprognostic (1.09e-1)" "unprognostic (5.82e-2)" "unprognostic (1.59e-1)" "unprognostic (4.19e-2)" "unprognostic (2.78e-1)" "unprognostic (1.33e-1)" 18.0 21.8 17.7 14.0 15.9 15.5 16.8 16.6 16.7 18.4 20.6 11.4 25.4 13.2 19.6 19.0 17.3 17.0 17.1 20.9 14.2 14.2 18.5 34.2 16.7 23.1 15.2 15.4 15.7 16.5 45.8 17.0 41.1 12.9 13.4 14.4 13.9 14.2 25.2 42.8 14.8 22.0 17.3 14.0 16.7 16.9 16.9 14.0 21.1 20.3 17.6 16.5 20.3 19.9 6.4 5.5 13.0 5.0 4.9 7.8 3.1 19.0 22.6 20.1 20.5 16.9 17.7 4.6 11.0 14.8 12.5 14.6 10.4 8.9 12.8 6.2 25.0 12.9 34.5 20.0 21.1 16.1 24.8 14.9 21.9 9.3 14.3 12.9 10.9 15.3 9.0 30.0 28.5 19.3 18.0 10.5 19.3 14.0 9.2 5.1 21.2 12.5 10.1 27.5 8.3 11.9 15.8 11.4 10.7 46.2 12.8 12.6 12.4 7.2 20.6 19.2 14.8 18.1 11.8 9.6 11.2 16.4 13.7 5.8 9.5 3.3 4.7 6.0 5.6 4.2 7.8 6.4 6.6 6.2 5.5 4.7 6.7 6.0 13.0 4.9 5.0 4.2 5.6 3.1 17.7 15.9 16.6 16.7 14.2 14.2 15.2 15.4 12.9 14.0 USP9Y DFFRY ENSG00000114374 "Ubiquitin specific peptidase 9, Y-linked" O00507 Y 12701231-12860839 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" "Ubl conjugation pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell line enhanced" "Detected in many" "RPTEC TERT1: 16.0;RT4: 8.6" "Cancer enhanced" "Detected in many" "prostate cancer: 5.7" "Low cell type specificity" "Detected in many" "Group enriched" "Detected in many" 5 "B-cells: 2.4;dendritic cells: 2.0;T-cells: 2.7" "Not detected" "Not detected" HPA057687 Uncertain Vesicles Vesicles "HPA057687: " "unprognostic (2.63e-1)" "unprognostic (8.97e-2)" "unprognostic (1.10e-5)" "unprognostic (8.46e-3)" "unprognostic (4.93e-2)" "unprognostic (2.53e-2)" "unprognostic (2.77e-1)" "unprognostic (3.17e-2)" "unprognostic (1.71e-1)" "unprognostic (4.05e-2)" "unprognostic (1.41e-4)" "unprognostic (2.28e-1)" "unprognostic (1.19e-2)" "unprognostic (1.42e-1)" 1.2 2.2 1.4 0.9 3.1 1.7 1.1 9.6 4.0 0.0 1.6 1.4 0.0 8.6 4.4 0.0 3.8 2.4 1.8 3.4 2.9 2.2 2.2 1.4 2.1 0.0 2.7 0.0 4.8 1.7 9.3 4.8 2.3 7.6 2.8 2.0 1.8 0.0 1.5 2.2 1.5 2.9 2.8 4.5 3.2 0.0 2.4 2.0 0.1 0.2 0.5 2.7 0.2 0.0 2.2 0.0 0.0 0.0 0.0 2.4 7.1 7.1 3.6 3.9 0.0 0.0 4.0 0.0 5.9 0.0 0.0 0.0 3.2 2.2 0.0 2.5 0.0 7.0 4.0 0.0 0.0 5.9 5.2 0.0 0.0 0.0 0.0 0.0 6.4 0.0 4.0 0.0 1.5 0.0 0.0 2.0 0.8 16.0 8.6 2.8 0.0 0.0 0.0 2.1 0.0 0.0 5.5 4.4 0.0 0.0 3.2 0.0 3.7 7.0 0.1 0.0 0.0 0.0 0.1 0.0 1.9 0.2 2.7 1.2 2.2 1.5 0.3 2.4 2.2 1.3 0.1 0.5 0.0 2.0 1.6 0.2 USPL1 "bA121O19.1, C13orf22, D13S106E" ENSG00000132952 "Ubiquitin specific peptidase like 1" Q5W0Q7 13 30617693-30660770 "Enzymes, Predicted intracellular proteins" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA039342, HPA040172" Uncertain "HPA039342: AB_10795105, HPA040172: AB_10796447" "unprognostic (5.74e-2)" "unprognostic (6.26e-2)" "unprognostic (8.16e-2)" "unprognostic (4.29e-2)" "unprognostic (4.96e-2)" "unprognostic (3.65e-1)" "unprognostic (1.00e-2)" "unprognostic (1.65e-1)" "unprognostic (1.20e-1)" "unprognostic (6.79e-2)" "unprognostic (2.21e-2)" "unprognostic (1.27e-2)" "unprognostic (3.18e-1)" "unprognostic (2.68e-1)" "unprognostic (1.49e-1)" "unprognostic (3.78e-1)" "unprognostic (5.32e-3)" 12.6 10.0 13.0 16.2 14.9 29.7 13.2 22.1 14.6 11.5 10.3 9.6 8.7 8.8 14.2 10.5 10.1 11.4 9.0 7.5 12.9 7.8 9.4 15.3 12.2 16.7 20.8 10.4 16.2 13.1 6.6 15.2 11.7 13.7 13.4 9.9 7.4 9.8 10.1 10.0 13.6 14.3 9.9 18.0 19.7 10.4 23.1 18.9 12.5 12.3 5.8 16.1 14.1 42.6 11.3 6.9 7.5 7.7 8.4 10.6 5.9 4.2 6.3 14.8 8.8 7.5 9.4 6.2 9.9 7.9 9.8 7.8 8.6 11.4 9.5 5.0 8.4 8.8 15.5 5.8 14.5 8.0 6.4 11.8 9.5 7.5 6.8 11.3 9.6 6.8 10.6 7.1 9.9 14.2 11.9 6.3 10.7 3.6 15.6 22.9 12.5 4.2 14.9 11.0 8.7 7.9 2.8 12.7 11.8 5.4 6.2 8.7 7.0 14.2 8.9 6.8 6.7 8.9 7.3 6.6 5.6 13.9 3.9 7.9 13.2 6.1 7.7 7.5 7.7 5.8 10.6 11.0 7.5 7.8 6.9 11.3 10.2 9.2 3.8 8.4 4.6 5.2 7.8 5.9 13.0 14.9 22.1 14.6 12.9 7.8 20.8 10.4 13.7 18.9 XPNPEP1 "XPNPEP, XPNPEPL, XPNPEPL1" ENSG00000108039 "X-prolyl aminopeptidase 1" Q9NQW7 10 109864766-109923553 "Enzymes, Predicted intracellular proteins" "Aminopeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB025196, HPA030419, HPA030420, HPA030422" Supported Enhanced Cytosol 760000 Cytosol "CAB025196: , HPA030419: AB_10598917, HPA030420: AB_10611523, HPA030422: AB_10601783" "unprognostic (3.17e-2)" "unprognostic (2.36e-2)" "unprognostic (1.11e-1)" "unprognostic (2.31e-2)" "unprognostic (2.46e-1)" "unprognostic (2.01e-3)" "prognostic unfavourable (2.12e-5)" "unprognostic (8.03e-2)" "unprognostic (2.10e-2)" "unprognostic (1.88e-1)" "unprognostic (4.89e-2)" "unprognostic (7.61e-2)" "unprognostic (2.43e-2)" "unprognostic (1.34e-2)" "unprognostic (1.74e-1)" "unprognostic (2.40e-1)" "unprognostic (5.18e-2)" 16.6 14.7 13.4 16.1 18.9 12.8 13.6 14.8 22.2 15.7 20.6 19.5 14.1 33.2 17.5 16.1 17.8 15.8 20.3 17.8 13.7 11.4 18.3 21.0 14.8 14.9 13.8 14.0 17.8 46.0 14.9 15.9 19.0 17.2 16.0 26.9 15.6 19.6 11.3 18.5 20.4 38.6 18.6 11.9 18.0 16.8 15.1 12.0 9.9 15.7 15.2 24.2 14.1 13.8 5.5 24.0 10.0 21.0 14.7 10.6 13.4 25.3 11.2 17.9 24.4 29.2 27.5 13.7 14.2 28.9 21.3 23.1 21.7 21.9 36.3 12.3 21.8 13.5 14.2 17.5 20.9 10.7 13.6 24.2 7.3 9.0 20.4 18.8 20.2 27.0 10.9 23.4 20.8 34.9 7.8 11.6 27.0 8.6 13.4 11.7 7.0 12.1 15.1 36.1 6.5 27.0 8.0 5.4 20.8 12.3 7.8 23.6 9.5 17.6 17.9 8.7 11.4 13.7 12.4 19.8 9.6 31.0 20.5 26.4 6.8 10.0 13.7 5.6 10.6 21.0 7.3 5.5 7.0 9.5 24.0 4.8 5.0 6.6 1.1 14.7 17.5 18.8 7.5 13.4 13.4 18.9 14.8 22.2 13.7 11.4 13.8 14.0 17.2 12.0 XPNPEP2 ENSG00000122121 "X-prolyl aminopeptidase 2" O43895 X 129738974-129769538 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" "Aminopeptidase, Hydrolase, Metalloprotease, Protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 9 "intestine: 145.6;kidney: 49.7" "Cell line enhanced" "Detected in some" "ASC diff: 6.2;ASC TERT1: 32.6;HSkMC: 16.5" "Group enriched" "Detected in many" 6 "colorectal cancer: 5.3;liver cancer: 18.3;stomach cancer: 3.9" "Not detected" "Not detected" "Group enriched" "Detected in many" 4 "gdT-cell: 7.3;intermediate monocyte: 2.1;MAIT T-cell: 2.2;memory CD4 T-cell: 2.4;memory CD8 T-cell: 4.8;naive CD8 T-cell: 3.6;non-classical monocyte: 4.4;T-reg: 2.2" "Group enriched" "Detected in many" 7 "monocytes: 4.4;T-cells: 7.3" "Low region specificity" "Detected in some" "Low region specificity" "Detected in all" "HPA000339, CAB025136, CAB025269, HPA064568" Enhanced Approved "Plasma membrane,Cytosol" "Intracellular and membrane" 8900000 "Plasma membrane, Cytosol" "CAB025136: , CAB025269: , HPA000339: AB_1858894, HPA064568: " "unprognostic (7.95e-2)" "unprognostic (5.73e-2)" "unprognostic (2.56e-1)" "unprognostic (6.21e-3)" "unprognostic (3.54e-2)" "unprognostic (1.54e-1)" "unprognostic (4.04e-1)" "unprognostic (3.26e-1)" "unprognostic (3.01e-1)" "unprognostic (2.41e-2)" "unprognostic (3.07e-1)" "unprognostic (9.28e-3)" "unprognostic (2.77e-2)" "unprognostic (6.53e-2)" "unprognostic (3.18e-2)" "unprognostic (1.39e-2)" "unprognostic (3.26e-3)" 4.7 0.5 0.0 1.1 0.1 0.0 3.2 0.0 0.1 1.7 57.4 0.1 0.8 37.0 1.2 1.7 4.2 3.4 1.3 2.6 0.0 0.0 49.7 8.0 1.0 1.2 0.0 0.0 3.5 0.9 0.0 0.0 0.6 0.1 3.6 2.0 0.7 0.7 0.3 1.6 2.1 145.6 2.5 0.1 0.2 1.7 1.2 0.0 0.1 0.9 1.4 0.3 4.0 10.7 0.4 0.8 0.2 4.4 0.0 7.3 1.3 0.0 0.0 0.4 0.0 6.2 32.6 0.3 0.0 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.5 0.8 0.0 0.0 16.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.2 0.0 0.0 0.4 0.0 0.6 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 1.6 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 7.3 2.1 2.2 0.0 2.4 4.8 0.3 0.4 0.7 3.6 0.2 0.0 4.4 0.8 2.2 1.3 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 XPNPEP3 "APP3, ICP55, NPHPL1" ENSG00000196236 "X-prolyl aminopeptidase 3" Q9NQH7 22 40857077-40932815 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" "Aminopeptidase, Hydrolase, Metalloprotease, Protease" "Disease mutation, Nephronophthisis" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" HPA000527 Approved "HPA000527: AB_1079266" "prognostic unfavourable (8.19e-4)" "unprognostic (6.77e-2)" "unprognostic (3.22e-3)" "unprognostic (5.03e-3)" "unprognostic (6.18e-2)" "unprognostic (1.29e-1)" "unprognostic (1.65e-1)" "unprognostic (1.13e-1)" "unprognostic (1.64e-1)" "unprognostic (2.53e-1)" "unprognostic (1.73e-2)" "unprognostic (1.51e-1)" "unprognostic (6.69e-2)" "unprognostic (8.00e-3)" "unprognostic (2.49e-1)" "prognostic unfavourable (6.10e-4)" "unprognostic (1.24e-1)" 8.2 13.6 7.5 5.8 9.2 4.7 9.7 5.2 7.8 7.3 6.1 10.8 11.6 32.3 10.7 12.3 7.2 9.4 10.5 11.2 7.6 7.1 9.8 19.0 6.6 10.6 7.9 6.1 10.7 10.5 8.0 15.0 6.1 10.7 7.3 6.2 9.3 8.5 13.6 12.0 11.5 20.9 7.1 9.3 7.7 6.8 18.9 8.2 11.5 9.1 7.3 8.8 12.6 8.2 5.9 6.0 6.4 10.0 1.2 4.4 4.0 3.2 4.7 3.2 7.0 9.0 6.0 2.2 4.1 3.1 2.3 2.3 3.9 2.1 6.5 2.3 7.9 7.6 6.0 3.2 3.4 3.9 12.4 4.2 9.3 7.3 4.1 7.3 0.7 5.2 5.0 7.2 4.3 4.0 3.5 5.9 4.8 5.0 3.5 3.9 1.9 9.6 4.9 4.3 3.7 6.4 4.4 2.8 2.5 4.0 6.1 3.8 7.1 3.3 4.0 4.7 4.1 4.3 2.4 5.5 4.2 7.9 7.2 9.6 3.2 4.0 4.4 4.4 3.4 3.9 1.8 5.9 2.1 2.2 3.1 3.7 4.4 3.3 6.4 1.2 10.0 6.0 3.0 4.0 7.5 9.2 5.2 7.8 7.6 7.1 7.9 6.1 10.7 8.2 YME1L1 ENSG00000136758 "YME1 like 1 ATPase" Q96TA2 10 27110112-27155266 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Metalloprotease, Protease" "Disease mutation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA066953 Approved Supported "Nuclear bodies,Mitochondria" Mitochondria "Nuclear bodies" "HPA066953: " "unprognostic (2.28e-3)" "unprognostic (3.00e-2)" "unprognostic (1.34e-1)" "unprognostic (7.19e-2)" "unprognostic (8.12e-2)" "unprognostic (2.47e-1)" "prognostic unfavourable (8.25e-6)" "unprognostic (7.08e-2)" "unprognostic (2.91e-1)" "unprognostic (9.24e-2)" "unprognostic (9.43e-3)" "unprognostic (1.64e-1)" "unprognostic (1.21e-1)" "unprognostic (1.03e-1)" "unprognostic (5.53e-2)" "unprognostic (1.44e-2)" "unprognostic (7.09e-2)" 27.8 37.3 22.7 25.0 26.2 41.4 39.2 27.8 27.5 27.6 24.3 15.7 29.8 22.3 29.9 35.9 34.5 25.3 24.4 34.1 23.4 21.5 26.8 45.4 26.9 38.7 19.3 25.5 32.5 33.8 27.8 28.6 33.4 22.0 25.9 26.3 23.3 28.1 31.3 79.0 26.8 25.3 34.6 20.2 26.5 24.7 24.7 20.9 41.7 30.9 32.0 28.9 36.4 28.9 55.6 79.2 73.9 53.0 45.5 56.0 45.9 40.0 30.1 36.1 17.8 35.4 38.1 29.5 39.6 23.2 40.7 46.7 40.7 49.4 42.8 26.4 43.7 38.8 43.3 35.0 45.0 38.8 26.0 40.6 26.9 28.5 38.9 27.7 33.4 31.2 41.4 35.5 36.0 42.5 47.1 43.6 44.9 27.1 51.2 16.0 28.6 14.1 44.3 57.9 39.5 33.2 19.1 27.8 35.6 39.6 30.8 39.7 29.5 34.8 41.6 24.7 34.5 41.4 35.5 21.9 32.1 54.7 35.1 51.5 18.8 53.0 53.0 55.2 55.3 44.8 56.0 51.4 53.8 51.2 42.6 55.6 49.7 51.9 73.9 45.5 47.3 79.2 52.6 45.9 22.7 26.2 27.8 27.5 23.4 21.5 19.3 25.5 22.0 20.9 ZMPSTE24 "FACE-1, HGPS, PRO1, STE24, Ste24p" ENSG00000084073 "Zinc metallopeptidase STE24" O75844 1 40258107-40294184 "Disease related genes, Enzymes, Potential drug targets, Predicted membrane proteins, Transporters" "Hydrolase, Metalloprotease, Protease" "Disease mutation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA006988 Approved Approved "Golgi apparatus,Cytosol" 13000 Cytosol "Golgi apparatus" "HPA006988: AB_1080659" "unprognostic (6.32e-2)" "unprognostic (1.63e-2)" "unprognostic (3.75e-3)" "unprognostic (4.63e-2)" "unprognostic (4.16e-3)" "unprognostic (1.37e-1)" "prognostic unfavourable (5.73e-6)" "unprognostic (1.86e-1)" "unprognostic (1.17e-1)" "unprognostic (1.84e-3)" "unprognostic (4.78e-2)" "unprognostic (7.96e-2)" "unprognostic (5.06e-2)" "unprognostic (3.65e-2)" "unprognostic (2.65e-1)" "prognostic unfavourable (6.34e-4)" "unprognostic (2.71e-2)" 21.6 24.2 17.6 15.4 19.6 6.5 18.6 10.7 21.3 20.9 20.6 14.9 27.0 17.9 29.7 19.7 21.4 19.9 20.7 20.8 17.1 16.9 34.2 48.7 16.2 23.1 21.9 17.0 16.0 20.4 39.8 17.0 23.0 23.5 21.7 23.3 15.6 18.9 19.0 19.1 14.7 20.9 25.2 19.2 17.7 19.0 10.7 17.9 20.9 20.6 14.7 18.4 19.1 16.7 15.1 25.8 15.1 23.9 24.2 22.5 20.3 20.7 13.9 10.8 8.1 28.7 23.0 21.0 21.8 18.2 24.6 22.5 15.1 36.0 17.9 15.1 26.6 21.6 22.0 20.0 28.4 16.8 14.1 17.3 14.8 13.8 16.4 27.8 21.7 16.6 20.6 21.0 9.1 17.3 18.3 18.0 23.3 9.7 16.8 8.3 20.7 14.5 14.6 19.2 22.2 21.8 20.1 11.3 13.3 20.1 44.9 27.0 16.5 76.8 17.1 22.3 16.3 20.7 26.4 11.1 29.6 15.6 24.4 19.5 23.6 15.1 20.0 13.6 17.9 23.9 21.5 15.1 19.1 18.9 25.8 11.6 17.0 22.5 11.8 24.2 22.7 16.9 22.3 20.3 17.6 19.6 10.7 21.3 17.1 16.9 21.9 17.0 23.5 17.9 ZRANB1 TRABID ENSG00000019995 "Zinc finger RANBP2-type containing 1" Q9UGI0 10 124942123-124988189 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway, Wnt signaling pathway" "Hydrolase, Protease, Thiol protease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA029239, HPA029240, HPA029241" Approved Supported Nucleoplasm,Cytosol Nucleoplasm Cytosol "HPA029239: AB_10599419, HPA029240: AB_10601450, HPA029241: AB_10602205" "unprognostic (2.06e-1)" "unprognostic (5.16e-2)" "unprognostic (6.96e-2)" "unprognostic (1.67e-1)" "unprognostic (1.40e-1)" "unprognostic (9.53e-3)" "unprognostic (4.16e-2)" "unprognostic (1.89e-1)" "unprognostic (1.71e-1)" "unprognostic (1.46e-1)" "unprognostic (4.20e-1)" "unprognostic (1.46e-1)" "unprognostic (1.22e-2)" "unprognostic (1.60e-1)" "unprognostic (2.76e-1)" "unprognostic (1.26e-1)" "unprognostic (1.47e-2)" 5.1 9.3 4.9 1.9 4.7 7.9 5.3 11.9 6.0 6.3 5.2 1.4 5.9 5.2 4.1 4.4 3.6 7.3 4.6 4.0 4.2 10.4 4.2 2.5 4.4 8.6 3.1 7.1 3.9 3.9 4.6 3.3 3.4 5.8 18.0 5.2 3.0 6.3 3.8 2.8 3.6 7.7 3.8 3.9 4.2 4.8 3.4 1.4 4.6 1.1 3.8 4.4 0.8 7.7 4.4 9.5 6.9 14.8 12.5 4.0 7.6 20.8 14.5 16.9 6.6 6.1 8.1 5.7 9.6 5.6 12.0 5.6 19.6 8.6 5.9 4.6 5.1 7.1 31.6 6.9 3.5 13.8 16.5 10.6 22.8 9.1 0.6 6.7 7.8 6.1 8.1 6.0 3.4 4.8 7.0 6.7 3.6 6.4 5.6 4.8 8.1 6.4 5.0 8.4 5.5 5.9 6.7 6.2 6.4 5.1 9.4 7.2 6.2 9.4 7.0 4.9 3.0 2.1 1.1 3.0 2.2 0.4 1.9 2.4 2.6 2.2 0.9 3.4 4.4 3.3 4.6 3.8 0.5 1.4 2.2 0.8