Gene "Gene synonym" Ensembl "Gene description" Uniprot Chromosome Position "Protein class" "Biological process" "Molecular function" "Disease involvement" Evidence "HPA evidence" "UniProt evidence" "NeXtProt evidence" "MS evidence" "RNA tissue specificity" "RNA tissue distribution" "RNA tissue specificity score" "RNA tissue specific NX" "RNA cell line specificity" "RNA cell line distribution" "RNA cell line specificity score" "RNA cell line specific NX" "RNA cancer specificity" "RNA cancer distribution" "RNA cancer specificity score" "RNA cancer specific FPKM" "RNA brain regional specificity" "RNA brain regional distribution" "RNA brain regional specificity score" "RNA brain regional specific NX" "RNA blood cell specificity" "RNA blood cell distribution" "RNA blood cell specificity score" "RNA blood cell specific NX" "RNA blood lineage specificity" "RNA blood lineage distribution" "RNA blood lineage specificity score" "RNA blood lineage specific NX" "RNA mouse brain regional specificity" "RNA mouse brain regional distribution" "RNA mouse brain regional specificity score" "RNA mouse brain regional specific pTPM" "RNA pig brain regional specificity" "RNA pig brain regional distribution" "RNA pig brain regional specificity score" "RNA pig brain regional specific pTPM" Antibody "Reliability (IH)" "Reliability (Mouse Brain)" "Reliability (IF)" "Subcellular location" "Secretome location" "Blood concentration - Conc. blood IM [pg/L]" "Blood concentration - Conc. blood MS [pg/L]" "Subcellular main location" "Subcellular additional location" "Antibody RRID" "Pathology prognostics - Breast cancer" "Pathology prognostics - Cervical cancer" "Pathology prognostics - Colorectal cancer" "Pathology prognostics - Endometrial cancer" "Pathology prognostics - Glioma" "Pathology prognostics - Head and neck cancer" "Pathology prognostics - Liver cancer" "Pathology prognostics - Lung cancer" "Pathology prognostics - Melanoma" "Pathology prognostics - Ovarian cancer" "Pathology prognostics - Pancreatic cancer" "Pathology prognostics - Prostate cancer" "Pathology prognostics - Renal cancer" "Pathology prognostics - Stomach cancer" "Pathology prognostics - Testis cancer" "Pathology prognostics - Thyroid cancer" "Pathology prognostics - Urothelial cancer" "Tissue RNA - adipose tissue [NX]" "Tissue RNA - adrenal gland [NX]" "Tissue RNA - amygdala [NX]" "Tissue RNA - appendix [NX]" "Tissue RNA - basal ganglia [NX]" "Tissue RNA - bone marrow [NX]" "Tissue RNA - breast [NX]" "Tissue RNA - cerebellum [NX]" "Tissue RNA - cerebral cortex [NX]" "Tissue RNA - cervix, uterine [NX]" "Tissue RNA - colon [NX]" "Tissue RNA - corpus callosum [NX]" "Tissue RNA - ductus deferens [NX]" "Tissue RNA - duodenum [NX]" "Tissue RNA - endometrium 1 [NX]" "Tissue RNA - epididymis [NX]" "Tissue RNA - esophagus [NX]" "Tissue RNA - fallopian tube [NX]" "Tissue RNA - gallbladder [NX]" "Tissue RNA - heart muscle [NX]" "Tissue RNA - hippocampal formation [NX]" "Tissue RNA - hypothalamus [NX]" "Tissue RNA - kidney [NX]" "Tissue RNA - liver [NX]" "Tissue RNA - lung [NX]" "Tissue RNA - lymph node [NX]" "Tissue RNA - midbrain [NX]" "Tissue RNA - olfactory region [NX]" "Tissue RNA - ovary [NX]" "Tissue RNA - pancreas [NX]" "Tissue RNA - parathyroid gland [NX]" "Tissue RNA - pituitary gland [NX]" "Tissue RNA - placenta [NX]" "Tissue RNA - pons and medulla [NX]" "Tissue RNA - prostate [NX]" "Tissue RNA - rectum [NX]" "Tissue RNA - retina [NX]" "Tissue RNA - salivary gland [NX]" "Tissue RNA - seminal vesicle [NX]" "Tissue RNA - skeletal muscle [NX]" "Tissue RNA - skin 1 [NX]" "Tissue RNA - small intestine [NX]" "Tissue RNA - smooth muscle [NX]" "Tissue RNA - spinal cord [NX]" "Tissue RNA - spleen [NX]" "Tissue RNA - stomach 1 [NX]" "Tissue RNA - testis [NX]" "Tissue RNA - thalamus [NX]" "Tissue RNA - thymus [NX]" "Tissue RNA - thyroid gland [NX]" "Tissue RNA - tongue [NX]" "Tissue RNA - tonsil [NX]" "Tissue RNA - urinary bladder [NX]" "Tissue RNA - vagina [NX]" "Tissue RNA - B-cells [NX]" "Tissue RNA - dendritic cells [NX]" "Tissue RNA - granulocytes [NX]" "Tissue RNA - monocytes [NX]" "Tissue RNA - NK-cells [NX]" "Tissue RNA - T-cells [NX]" "Tissue RNA - total PBMC [NX]" "Cell RNA - A-431 [NX]" "Cell RNA - A549 [NX]" "Cell RNA - AF22 [NX]" "Cell RNA - AN3-CA [NX]" "Cell RNA - ASC diff [NX]" "Cell RNA - ASC TERT1 [NX]" "Cell RNA - BEWO [NX]" "Cell RNA - BJ [NX]" "Cell RNA - BJ hTERT+ [NX]" "Cell RNA - BJ hTERT+ SV40 Large T+ [NX]" "Cell RNA - BJ hTERT+ SV40 Large T+ RasG12V [NX]" "Cell RNA - CACO-2 [NX]" "Cell RNA - CAPAN-2 [NX]" "Cell RNA - Daudi [NX]" "Cell RNA - EFO-21 [NX]" "Cell RNA - fHDF/TERT166 [NX]" "Cell RNA - HaCaT [NX]" "Cell RNA - HAP1 [NX]" "Cell RNA - HBEC3-KT [NX]" "Cell RNA - HBF TERT88 [NX]" "Cell RNA - HDLM-2 [NX]" "Cell RNA - HEK 293 [NX]" "Cell RNA - HEL [NX]" "Cell RNA - HeLa [NX]" "Cell RNA - Hep G2 [NX]" "Cell RNA - HHSteC [NX]" "Cell RNA - HL-60 [NX]" "Cell RNA - HMC-1 [NX]" "Cell RNA - HSkMC [NX]" "Cell RNA - hTCEpi [NX]" "Cell RNA - hTEC/SVTERT24-B [NX]" "Cell RNA - hTERT-HME1 [NX]" "Cell RNA - HUVEC TERT2 [NX]" "Cell RNA - K-562 [NX]" "Cell RNA - Karpas-707 [NX]" "Cell RNA - LHCN-M2 [NX]" "Cell RNA - MCF7 [NX]" "Cell RNA - MOLT-4 [NX]" "Cell RNA - NB-4 [NX]" "Cell RNA - NTERA-2 [NX]" "Cell RNA - PC-3 [NX]" "Cell RNA - REH [NX]" "Cell RNA - RH-30 [NX]" "Cell RNA - RPMI-8226 [NX]" "Cell RNA - RPTEC TERT1 [NX]" "Cell RNA - RT4 [NX]" "Cell RNA - SCLC-21H [NX]" "Cell RNA - SH-SY5Y [NX]" "Cell RNA - SiHa [NX]" "Cell RNA - SK-BR-3 [NX]" "Cell RNA - SK-MEL-30 [NX]" "Cell RNA - T-47d [NX]" "Cell RNA - THP-1 [NX]" "Cell RNA - TIME [NX]" "Cell RNA - U-138 MG [NX]" "Cell RNA - U-2 OS [NX]" "Cell RNA - U-2197 [NX]" "Cell RNA - U-251 MG [NX]" "Cell RNA - U-266/70 [NX]" "Cell RNA - U-266/84 [NX]" "Cell RNA - U-698 [NX]" "Cell RNA - U-87 MG [NX]" "Cell RNA - U-937 [NX]" "Cell RNA - WM-115 [NX]" "Blood RNA - basophil [NX]" "Blood RNA - classical monocyte [NX]" "Blood RNA - eosinophil [NX]" "Blood RNA - gdT-cell [NX]" "Blood RNA - intermediate monocyte [NX]" "Blood RNA - MAIT T-cell [NX]" "Blood RNA - memory B-cell [NX]" "Blood RNA - memory CD4 T-cell [NX]" "Blood RNA - memory CD8 T-cell [NX]" "Blood RNA - myeloid DC [NX]" "Blood RNA - naive B-cell [NX]" "Blood RNA - naive CD4 T-cell [NX]" "Blood RNA - naive CD8 T-cell [NX]" "Blood RNA - neutrophil [NX]" "Blood RNA - NK-cell [NX]" "Blood RNA - non-classical monocyte [NX]" "Blood RNA - plasmacytoid DC [NX]" "Blood RNA - T-reg [NX]" "Blood RNA - total PBMC [NX]" "Brain RNA - amygdala [NX]" "Brain RNA - basal ganglia [NX]" "Brain RNA - cerebellum [NX]" "Brain RNA - cerebral cortex [NX]" "Brain RNA - hippocampal formation [NX]" "Brain RNA - hypothalamus [NX]" "Brain RNA - midbrain [NX]" "Brain RNA - olfactory region [NX]" "Brain RNA - pons and medulla [NX]" "Brain RNA - thalamus [NX]" MCOLN1 "ML4, MLIV, MST080, MSTP080, TRPM-L1, TRPML1" ENSG00000090674 "Mucolipin 1" Q9GZU1 19 7522626-7534009 "Disease related genes, Potential drug targets, Predicted membrane proteins, Transporters, Voltage-gated ion channels" "Adaptive immunity, Calcium transport, Immunity, Ion transport, Transport" "Ion channel" "Disease mutation, Mucolipidosis" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Group enriched" "Detected in all" 5 "granulocytes: 30.9;monocytes: 28.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA031763, CAB032637, HPA069495" Uncertain Supported "Nucleoplasm,Golgi apparatus,Vesicles" "Golgi apparatus, Vesicles" Nucleoplasm "CAB032637: AB_2142964, HPA031763: AB_10600822, HPA069495: " "unprognostic (5.51e-2)" "unprognostic (1.31e-2)" "unprognostic (1.35e-2)" "unprognostic (3.30e-2)" "unprognostic (2.66e-1)" "unprognostic (4.07e-2)" "unprognostic (8.38e-3)" "unprognostic (1.57e-1)" "unprognostic (1.79e-2)" "unprognostic (1.47e-1)" "prognostic favourable (5.60e-5)" "unprognostic (1.36e-1)" "prognostic favourable (5.67e-4)" "unprognostic (2.58e-1)" "unprognostic (1.66e-1)" "unprognostic (1.07e-1)" "unprognostic (1.83e-1)" 18.9 27.5 10.1 10.3 11.9 10.0 10.3 8.2 19.7 7.7 9.6 11.2 7.2 9.6 8.8 9.5 11.2 8.4 11.7 11.7 9.0 9.2 11.5 20.6 17.9 20.6 10.6 10.0 7.8 10.5 9.8 26.0 17.9 13.6 8.8 6.9 9.7 9.2 8.0 14.2 13.9 8.0 9.5 10.4 38.3 8.9 6.5 9.4 7.0 6.2 7.6 5.1 12.5 8.7 1.3 6.2 30.9 28.9 2.8 2.7 4.4 6.3 6.5 3.2 10.8 18.7 6.0 9.2 11.9 9.6 14.4 12.5 5.0 5.6 3.5 14.7 8.0 2.9 5.4 4.1 4.3 6.9 11.9 3.1 6.4 4.0 16.4 3.6 14.0 8.5 9.6 13.8 2.4 6.1 5.9 15.9 8.3 2.1 4.9 3.6 7.1 14.1 6.8 5.4 7.6 5.4 5.5 8.3 10.2 5.1 9.0 15.0 5.4 6.3 7.5 6.9 3.9 27.8 8.8 12.3 18.8 2.5 11.1 5.0 10.3 30.9 13.7 29.7 2.3 27.5 2.0 1.1 2.0 1.9 5.6 1.3 1.9 2.0 12.2 2.8 28.9 6.2 2.7 4.4 10.1 11.9 8.2 19.7 9.0 9.2 10.6 10.0 13.6 9.4 MCOLN2 "FLJ36691, TRP-ML2, TRPML2" ENSG00000153898 "Mucolipin 2" Q8IZK6 1 84925583-84997113 "Predicted membrane proteins, Transporters, Voltage-gated ion channels" "Adaptive immunity, Calcium transport, Immunity, Innate immunity, Ion transport, Protein transport, Transport" "Calcium channel, Ion channel" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "blood: 18.9;epididymis: 18.4;lymphoid tissue: 31.9" "Cell line enhanced" "Detected in many" "Daudi: 13.8;HAP1: 9.9;HDLM-2: 16.4;THP-1: 19.7;U-698: 12.3" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in single" "Cell type enhanced" "Detected in many" "plasmacytoid DC: 18.9" "Group enriched" "Detected in many" 12 "B-cells: 6.6;dendritic cells: 18.9;T-cells: 5.9" "Region enriched" "Detected in single" 5 "amygdala: 0.4" "Low region specificity" "Detected in all" "HPA019114, HPA048999" Uncertain Supported "Intermediate filaments" "Intermediate filaments" "HPA019114: AB_1853645, HPA048999: " "unprognostic (3.02e-2)" "unprognostic (5.67e-2)" "unprognostic (3.07e-1)" "unprognostic (1.44e-1)" "unprognostic (2.47e-1)" "unprognostic (5.66e-3)" "unprognostic (2.38e-1)" "prognostic favourable (2.56e-4)" "unprognostic (8.92e-2)" "unprognostic (1.48e-2)" "unprognostic (6.84e-2)" "unprognostic (2.21e-2)" "unprognostic (3.12e-4)" "unprognostic (3.68e-2)" "unprognostic (4.69e-2)" "unprognostic (1.24e-1)" "unprognostic (4.23e-2)" 1.3 12.5 0.4 31.9 0.4 2.2 1.1 0.2 0.4 1.7 8.5 0.5 1.6 1.2 1.4 18.4 1.3 2.9 3.8 2.0 0.6 0.4 1.4 0.6 7.5 18.4 0.6 0.0 1.0 1.8 0.0 1.2 2.1 1.5 1.5 14.0 1.6 3.2 0.9 0.6 1.8 7.5 0.5 1.7 9.7 1.7 2.7 0.4 4.1 1.0 2.8 27.5 2.3 1.3 6.6 18.9 0.2 0.8 0.4 5.9 1.4 1.0 1.1 0.1 2.9 0.6 0.2 0.4 0.7 3.8 0.9 1.2 0.0 0.1 13.8 0.4 0.0 0.1 9.9 1.2 1.1 16.4 7.3 1.4 0.4 0.0 0.8 0.3 1.3 0.2 0.0 0.9 0.8 0.1 0.0 0.3 0.2 0.4 0.2 0.1 1.1 1.9 0.1 2.3 0.0 0.1 0.3 0.7 0.0 0.1 0.2 6.1 1.7 19.7 0.1 0.9 1.5 0.1 2.6 0.1 0.0 12.3 0.8 0.1 2.4 0.1 0.2 0.0 4.1 0.8 1.3 6.6 3.3 5.9 4.5 1.9 0.5 3.4 0.2 0.4 0.1 18.9 0.2 1.4 0.4 0.4 0.2 0.4 0.6 0.4 0.6 0.0 1.5 0.4 MCOLN3 "FLJ11006, TRP-ML3, TRPML3" ENSG00000055732 "Mucolipin 3" Q8TDD5 1 85018082-85048499 "Predicted membrane proteins, Transporters, Voltage-gated ion channels" "Ion transport, Transport" "Ion channel" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "adrenal gland: 29.2;pituitary gland: 38.3" "Cell line enhanced" "Detected in many" "BJ hTERT+: 9.8;HAP1: 9.8;RH-30: 11.9;SK-MEL-30: 21.2" "Cancer enriched" "Detected in many" 6 "melanoma: 8.0" "Low region specificity" "Detected in some" "Cell type enhanced" "Detected in some" "memory CD4 T-cell: 2.9" "Lineage enriched" "Detected in single" 29 "T-cells: 2.9" "Not detected" "Not detected" "Region enhanced" "Detected in single" "olfactory region: 1.7" "HPA018106, HPA062137" Enhanced Approved Nucleoli,Cytosol "Nucleoli, Cytosol" "HPA018106: AB_1853647, HPA062137: " "unprognostic (5.91e-2)" "unprognostic (1.24e-1)" "unprognostic (1.49e-2)" "unprognostic (3.21e-5)" "unprognostic (2.25e-1)" "unprognostic (8.80e-3)" "unprognostic (3.97e-3)" "unprognostic (1.13e-1)" "unprognostic (2.04e-1)" "unprognostic (1.10e-1)" "unprognostic (1.45e-3)" "unprognostic (3.09e-2)" "unprognostic (7.32e-5)" "unprognostic (6.36e-3)" "unprognostic (2.61e-1)" "unprognostic (6.11e-2)" "unprognostic (6.43e-2)" 4.7 29.2 1.5 0.8 0.8 0.0 3.0 0.2 0.4 6.1 2.8 0.9 2.1 3.2 5.4 15.6 0.8 1.1 0.6 5.1 3.4 0.3 4.5 0.2 4.1 0.0 0.5 0.0 2.2 6.5 17.9 38.3 1.8 2.7 0.5 0.5 4.5 8.1 0.4 1.9 2.5 1.9 1.1 0.3 0.9 1.6 0.4 0.3 2.6 1.5 0.9 0.4 0.7 2.8 0.0 0.0 0.0 0.0 0.0 2.9 0.7 6.4 1.5 0.0 0.0 5.2 4.7 1.6 0.1 9.8 2.5 6.9 0.5 1.2 0.0 0.7 0.1 0.0 9.8 3.2 1.6 2.6 5.8 0.0 0.5 0.0 0.0 0.0 0.0 0.5 1.2 2.1 1.1 0.0 0.0 0.0 4.8 0.6 0.0 0.0 0.7 0.6 0.0 11.9 0.0 0.3 0.0 0.4 0.0 0.3 0.0 21.2 4.0 4.9 0.0 1.9 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.9 0.8 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 1.5 0.8 0.2 0.4 3.4 0.3 0.5 0.0 2.7 0.3 PKD2 "Pc-2, PC2, PKD4, TRPP2" ENSG00000118762 "Polycystin 2, transient receptor potential cation channel" Q13563 4 88007668-88077777 "Disease related genes, Plasma proteins, Potential drug targets, Predicted membrane proteins, Transporters, Voltage-gated ion channels" "Calcium transport, Ion transport, Potassium transport, Transport, Wnt signaling pathway" "Calcium channel, Ion channel, Potassium channel, Voltage-gated channel" "Ciliopathy, Disease mutation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell line enhanced" "Detected in many" "BJ: 36.5;BJ hTERT+: 55.4;fHDF/TERT166: 43.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Cell type enhanced" "Detected in some" "basophil: 4.8" "Low lineage specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004544, HPA015794" Approved Supported "Endoplasmic reticulum" "Endoplasmic reticulum" "CAB004544: AB_672377, HPA015794: AB_1855437" "unprognostic (2.01e-1)" "unprognostic (3.57e-2)" "unprognostic (1.22e-1)" "unprognostic (6.83e-2)" "unprognostic (9.71e-2)" "unprognostic (1.97e-1)" "unprognostic (3.17e-2)" "unprognostic (1.88e-1)" "unprognostic (8.64e-2)" "unprognostic (1.08e-1)" "unprognostic (6.59e-2)" "unprognostic (1.09e-1)" "unprognostic (1.17e-3)" "unprognostic (3.54e-3)" "unprognostic (1.07e-1)" "unprognostic (1.12e-2)" "unprognostic (2.51e-1)" 18.4 13.6 8.2 7.7 10.9 5.0 15.1 15.1 10.7 31.4 19.4 15.5 18.5 5.6 42.7 9.8 13.9 25.7 15.3 12.8 9.0 5.2 27.5 7.9 13.4 5.5 12.6 6.4 27.0 9.8 21.9 8.1 12.8 9.2 15.6 7.3 14.1 7.4 22.3 5.4 6.2 9.6 29.3 7.2 5.4 14.8 9.9 12.0 5.5 10.2 3.3 4.9 13.9 21.4 0.5 1.3 4.8 0.8 1.0 1.4 0.4 1.9 10.8 12.2 6.2 28.2 18.9 3.6 36.5 55.4 17.1 17.1 0.5 3.4 1.0 8.0 43.9 2.4 2.1 5.4 15.0 5.5 1.9 1.7 5.5 1.1 15.7 4.1 3.5 15.6 2.4 13.4 7.2 7.7 0.2 2.9 14.9 3.7 2.9 2.0 6.3 1.8 5.6 7.2 1.5 15.2 4.5 2.4 5.5 6.7 0.3 8.6 2.6 3.1 11.8 16.2 3.5 4.5 4.9 2.3 0.7 1.1 9.6 0.6 14.8 4.8 0.5 0.9 0.8 0.8 1.4 0.5 0.8 0.6 0.3 0.5 0.9 0.6 0.9 1.0 0.3 1.3 0.4 0.4 8.2 10.9 15.1 10.7 9.0 5.2 12.6 6.4 9.2 12.0 PKD2L1 "PCL, PKD2L, PKDL, TRPP3" ENSG00000107593 "Polycystin 2 like 1, transient receptor potential cation channel" Q9P0L9 10 100288154-100330486 "Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters, Voltage-gated ion channels" "Calcium transport, Ion transport, Transport" "Calcium channel, Ion channel" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "brain: 6.2;lymphoid tissue: 12.0" "Cell line enhanced" "Detected in some" "Karpas-707: 1.6;NB-4: 1.7;PC-3: 1.9;RT4: 1.0;SK-MEL-30: 1.6;U-266/70: 1.0;U-266/84: 2.7;U-937: 1.3" "Low cancer specificity" "Detected in single" "Low region specificity" "Detected in many" "Group enriched" "Detected in some" 4 "classical monocyte: 2.7;intermediate monocyte: 3.0;non-classical monocyte: 2.3" "Lineage enriched" "Detected in single" 5 "monocytes: 3.0" "Low region specificity" "Detected in many" "Low region specificity" "Detected in single" CAB022621 Uncertain "CAB022621: " "unprognostic (2.67e-1)" "unprognostic (3.66e-7)" "unprognostic (8.07e-3)" "unprognostic (4.38e-2)" "unprognostic (4.70e-2)" "unprognostic (5.31e-2)" "unprognostic (2.19e-1)" "unprognostic (2.85e-2)" "unprognostic (2.01e-1)" "unprognostic (9.25e-2)" "unprognostic (1.55e-1)" "unprognostic (9.37e-2)" "unprognostic (1.49e-4)" "unprognostic (3.00e-1)" "unprognostic (2.05e-2)" "unprognostic (7.94e-2)" "unprognostic (2.25e-1)" 0.3 0.3 0.4 0.6 3.7 1.3 1.4 0.1 6.2 0.1 1.5 0.2 0.0 0.0 0.1 0.0 0.1 0.1 0.0 0.1 2.0 0.3 0.5 2.7 4.0 2.3 0.5 4.0 0.2 0.2 0.0 0.2 0.7 1.3 0.4 2.2 1.0 0.3 0.0 0.1 0.1 0.8 0.0 1.5 12.0 0.1 2.3 0.0 0.3 0.1 0.0 2.9 0.4 0.1 0.2 0.3 0.6 3.0 0.0 0.1 0.4 0.0 0.0 0.0 0.6 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.6 0.0 0.0 0.0 1.7 0.0 1.9 0.0 0.0 0.0 0.0 1.0 0.4 0.0 0.0 0.0 1.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 2.7 0.0 0.0 1.3 0.0 0.0 2.7 0.0 0.0 3.0 0.0 0.0 0.0 0.0 0.3 0.2 0.0 0.1 0.6 0.0 2.3 0.0 0.0 0.4 0.4 3.7 0.1 6.2 2.0 0.3 0.5 4.0 1.3 0.0 PKD2L2 TRPP5 ENSG00000078795 "Polycystin 2 like 2, transient receptor potential cation channel" Q9NZM6 5 137887968-137942747 "Predicted intracellular proteins, Predicted membrane proteins, Voltage-gated ion channels" "Ion transport, Transport" "Ion channel" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 6 "blood: 7.5;testis: 29.3" "Cell line enhanced" "Detected in many" "Karpas-707: 5.8;U-266/70: 4.6" "Not detected" "Not detected" "Low region specificity" "Detected in many" "Low cell type specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in some" "Low region specificity" "Detected in all" "HPA041903, HPA043634" Approved Approved "Plasma membrane,Cytosol" "Plasma membrane" Cytosol "HPA041903: , HPA043634: " "unprognostic (7.53e-3)" "unprognostic (2.21e-2)" "unprognostic (1.90e-1)" "unprognostic (3.59e-1)" "unprognostic (4.04e-1)" "unprognostic (1.21e-2)" "unprognostic (3.06e-1)" "unprognostic (1.40e-4)" "unprognostic (1.64e-2)" "unprognostic (2.13e-2)" "unprognostic (3.00e-2)" "unprognostic (5.85e-2)" "unprognostic (1.05e-3)" "unprognostic (2.21e-2)" "unprognostic (1.12e-1)" "unprognostic (1.28e-2)" "unprognostic (1.22e-1)" 0.5 1.5 2.0 0.6 2.5 2.2 1.2 1.7 1.9 0.5 0.3 0.7 0.7 0.3 0.5 1.0 0.5 0.4 0.6 1.7 1.0 0.8 0.4 0.3 0.4 1.3 1.2 1.3 0.6 1.1 0.0 1.5 0.2 1.8 0.5 0.1 0.2 0.7 0.0 3.3 0.8 0.3 0.0 0.7 1.0 0.6 29.3 0.4 0.0 1.0 0.0 0.2 0.4 0.6 3.9 3.5 7.5 1.7 1.9 1.9 0.8 1.6 1.2 0.2 0.1 0.4 0.5 1.7 0.6 0.0 0.0 0.0 0.1 3.2 2.3 3.4 0.0 0.7 0.1 0.0 0.1 1.5 1.0 1.3 4.2 0.1 0.0 0.4 1.8 0.1 0.2 0.0 0.0 0.6 1.5 5.8 0.8 0.5 1.1 2.3 0.6 1.0 0.0 0.1 0.0 0.0 2.3 0.8 0.9 1.4 0.2 0.9 0.4 0.5 0.5 1.0 1.8 0.6 1.0 4.6 3.3 0.4 2.2 0.7 1.7 7.1 1.7 3.0 1.8 1.2 1.0 2.5 1.6 1.4 0.9 3.9 1.9 1.7 7.5 1.9 1.0 3.5 1.1 0.8 2.0 2.5 1.7 1.9 1.0 0.8 1.2 1.3 1.8 0.4 TRPA1 ANKTM1 ENSG00000104321 "Transient receptor potential cation channel subfamily A member 1" O75762 8 72019917-72075617 "Disease related genes, FDA approved drug targets, Predicted membrane proteins, Transporters, Voltage-gated ion channels" "Ion transport, Sensory transduction, Transport" "Ion channel" "Disease mutation, FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "intestine: 20.8;urinary bladder: 20.1;vagina: 12.1" "Cell line enriched" "Detected in some" 6 "HHSteC: 24.1" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Cell type enhanced" "Detected in some" "memory CD8 T-cell: 2.6" "Low lineage specificity" "Detected in many" "Low region specificity" "Detected in single" "Low region specificity" "Detected in all" "unprognostic (2.14e-2)" "unprognostic (2.50e-2)" "prognostic favourable (6.57e-4)" "unprognostic (1.28e-2)" "unprognostic (2.34e-1)" "unprognostic (1.95e-1)" "unprognostic (1.37e-2)" "unprognostic (8.11e-3)" "unprognostic (4.22e-2)" "unprognostic (2.47e-1)" "unprognostic (2.78e-3)" "unprognostic (1.49e-1)" "unprognostic (2.16e-4)" "unprognostic (2.37e-1)" "unprognostic (9.67e-2)" "unprognostic (1.57e-1)" "unprognostic (2.90e-1)" 0.3 0.2 0.2 9.1 0.2 0.0 0.2 0.2 0.4 0.4 16.8 0.3 0.0 4.8 0.2 0.3 2.2 0.2 5.7 0.3 0.2 0.2 0.2 0.2 0.3 0.8 0.3 0.0 0.4 0.2 0.0 0.2 0.3 0.1 4.7 7.5 0.0 0.2 0.0 0.2 0.2 20.8 3.8 0.2 0.4 7.9 0.4 0.0 0.6 0.2 0.3 1.4 20.1 12.1 0.5 0.6 0.1 1.1 0.3 2.6 0.2 0.0 2.4 0.7 0.0 0.0 0.1 0.0 0.3 2.2 0.2 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.8 0.4 1.3 0.1 0.0 0.5 0.0 24.1 0.0 0.2 1.6 0.0 1.1 0.2 0.0 0.0 0.0 2.9 0.0 0.0 0.1 0.5 0.0 0.0 1.2 0.0 0.0 0.0 0.1 0.1 0.4 0.0 2.3 0.0 0.3 0.0 0.1 3.8 1.1 0.0 0.3 0.2 0.0 1.8 0.0 1.7 0.0 0.0 0.0 0.3 0.0 1.1 0.5 0.5 2.6 0.0 0.5 0.0 0.4 0.1 0.3 1.1 0.6 1.0 0.2 0.2 0.2 0.2 0.4 0.2 0.2 0.3 0.0 0.1 0.0 TRPC1 HTRP-1 ENSG00000144935 "Transient receptor potential cation channel subfamily C member 1" P48995 3 142724074-142807888 "Predicted membrane proteins, Transporters, Voltage-gated ion channels" "Calcium transport, Ion transport, Transport" "Calcium channel, Ion channel" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell line enhanced" "Detected in many" "ASC TERT1: 19.1" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in some" "Low lineage specificity" "Detected in single" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB009387, HPA021130" Supported Approved Vesicles Vesicles "CAB009387: AB_2240941, HPA021130: AB_1858361" "unprognostic (1.66e-1)" "unprognostic (7.38e-2)" "unprognostic (1.56e-2)" "unprognostic (4.37e-5)" "unprognostic (5.53e-1)" "unprognostic (1.40e-2)" "unprognostic (5.90e-3)" "unprognostic (1.59e-2)" "unprognostic (1.36e-1)" "unprognostic (2.17e-1)" "unprognostic (8.46e-3)" "unprognostic (6.25e-2)" "prognostic unfavourable (2.72e-5)" "unprognostic (1.44e-3)" "unprognostic (1.57e-1)" "unprognostic (1.61e-1)" "unprognostic (2.49e-2)" 6.8 8.3 8.5 3.5 13.4 1.2 6.8 23.0 15.9 17.7 8.3 11.4 4.3 2.6 20.4 9.2 6.5 10.1 9.1 15.9 10.0 11.4 6.0 2.0 5.4 3.3 9.4 12.2 24.5 3.0 12.2 14.4 6.1 14.7 12.3 4.9 13.0 3.7 13.6 2.4 6.2 4.7 17.6 11.4 5.0 4.4 8.0 7.9 0.4 8.9 3.9 2.3 9.3 8.9 0.6 0.0 0.0 0.0 0.3 1.3 0.3 3.3 4.7 8.6 1.0 7.8 19.1 3.9 5.3 8.3 6.7 9.8 1.5 0.9 0.0 1.7 5.4 0.3 2.4 2.4 9.6 0.8 3.4 5.2 2.0 2.2 3.2 0.3 0.0 9.1 2.4 6.2 7.4 3.8 0.2 0.0 9.3 2.1 0.3 0.4 4.8 2.5 0.0 4.1 0.0 4.6 0.1 5.5 4.0 6.4 0.0 1.1 2.7 0.0 3.5 8.4 1.3 11.2 7.0 3.5 1.5 1.7 6.4 0.1 2.5 0.0 0.0 0.0 0.2 0.0 1.2 0.6 1.3 0.6 0.0 0.3 1.2 1.3 0.0 0.3 0.0 0.0 0.0 0.3 8.5 13.4 23.0 15.9 10.0 11.4 9.4 12.2 14.7 7.9 TRPC3 ENSG00000138741 "Transient receptor potential cation channel subfamily C member 3" Q13507 4 121879027-121951754 "Disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters, Voltage-gated ion channels" "Calcium transport, Ion transport, Transport" "Calcium channel, Ion channel" "Disease mutation, Neurodegeneration, Spinocerebellar ataxia" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 9.3;pituitary gland: 12.0;smooth muscle: 9.4" "Cell line enhanced" "Detected in some" "HEK 293: 3.7;HEL: 5.5;Karpas-707: 5.8;U-2 OS: 3.7;U-251 MG: 3.3" "Not detected" "Not detected" "Low region specificity" "Detected in all" "Cell type enriched" "Detected in single" 9 "MAIT T-cell: 1.7" "Lineage enriched" "Detected in single" 18 "T-cells: 1.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" "unprognostic (1.08e-1)" "unprognostic (1.19e-1)" "unprognostic (2.39e-1)" "unprognostic (3.12e-2)" "unprognostic (5.57e-2)" "unprognostic (1.93e-2)" "unprognostic (7.12e-3)" "unprognostic (9.80e-2)" "unprognostic (4.80e-3)" "unprognostic (2.38e-1)" "unprognostic (3.26e-1)" "unprognostic (1.06e-1)" "unprognostic (4.33e-3)" "unprognostic (2.67e-3)" "unprognostic (1.39e-1)" "unprognostic (2.23e-1)" "unprognostic (8.42e-3)" 1.4 0.4 1.8 0.7 9.3 0.3 0.5 5.8 7.4 3.3 0.8 1.7 0.8 0.8 1.6 1.2 0.6 1.1 7.3 0.5 1.8 2.3 0.7 0.5 2.9 0.5 2.3 1.9 0.8 0.2 0.6 12.0 4.2 7.3 1.1 0.8 0.3 0.8 2.5 0.6 0.5 1.2 9.4 1.1 1.0 0.9 1.6 3.6 0.0 0.6 0.0 0.4 3.6 2.4 0.0 0.0 0.0 0.0 0.0 1.7 0.0 0.0 0.0 1.8 0.0 0.0 0.0 0.0 1.3 1.0 1.5 0.6 0.0 0.0 0.0 0.0 1.0 0.0 0.9 0.0 0.1 0.0 3.7 5.5 0.1 0.0 0.2 1.5 0.5 0.6 0.0 0.1 0.0 0.0 0.0 5.8 1.2 0.0 1.6 0.0 1.0 0.5 0.0 0.1 0.0 0.0 0.0 2.7 0.1 0.0 0.0 0.0 0.0 0.0 0.0 2.8 3.7 0.0 3.3 0.3 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.7 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.8 9.3 5.8 7.4 1.8 2.3 2.3 1.9 7.3 3.6 TRPC4 "HTRP4, TRP4" ENSG00000133107 "Transient receptor potential cation channel subfamily C member 4" Q9UBN4 13 37636636-37870425 "Plasma proteins, Predicted membrane proteins, Transporters, Voltage-gated ion channels" "Calcium transport, Ion transport, Transport" "Calcium channel, Ion channel" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "endometrium 1: 31.0;smooth muscle: 17.2" "Cell line enhanced" "Detected in some" "AF22: 7.0;BJ: 16.4;BJ hTERT+ SV40 Large T+: 7.0;fHDF/TERT166: 15.6;U-2197: 7.4" "Low cancer specificity" "Detected in some" "Low region specificity" "Detected in many" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" "unprognostic (4.52e-4)" "unprognostic (9.99e-2)" "unprognostic (5.42e-2)" "unprognostic (2.38e-1)" "unprognostic (1.19e-1)" "unprognostic (2.57e-1)" "unprognostic (3.28e-1)" "unprognostic (1.60e-1)" "unprognostic (5.10e-2)" "unprognostic (1.99e-1)" "unprognostic (1.47e-2)" "unprognostic (3.95e-2)" "unprognostic (1.07e-6)" "unprognostic (3.73e-3)" "unprognostic (1.93e-2)" "unprognostic (3.24e-1)" "unprognostic (1.43e-2)" 1.3 0.8 4.6 1.2 4.0 0.2 0.6 2.1 4.0 5.5 4.1 0.6 6.9 0.8 31.0 2.1 0.4 1.9 4.5 1.9 4.8 2.1 3.0 0.5 4.2 0.3 2.5 0.4 3.8 1.8 0.7 0.5 4.6 3.9 9.5 1.1 0.1 0.5 12.6 0.4 0.5 1.6 17.2 2.5 0.5 3.6 0.8 2.5 0.0 1.1 0.0 0.3 3.3 2.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 7.0 0.0 1.1 2.3 0.0 16.4 2.2 7.0 3.8 0.0 0.2 0.0 0.0 15.6 0.0 0.1 0.0 3.5 0.0 0.1 0.0 0.3 0.0 2.7 0.0 0.0 1.0 0.0 2.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 1.5 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.1 0.1 7.4 1.4 3.9 0.9 0.0 1.6 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.6 4.0 2.1 4.0 4.8 2.1 2.5 0.4 3.9 2.5 TRPC5 PPP1R159 ENSG00000072315 "Transient receptor potential cation channel subfamily C member 5" Q9UL62 X 111774315-112082776 "Predicted membrane proteins, Transporters, Voltage-gated ion channels" "Calcium transport, Ion transport, Transport" "Calcium channel, Ion channel" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 11 "brain: 5.3;liver: 3.2" "Cell line enriched" "Detected in single" 6 "NTERA-2: 6.2" "Group enriched" "Detected in some" 23 "testis cancer: 0.8;thyroid cancer: 2.8" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" "unprognostic (3.29e-2)" "unprognostic (6.15e-2)" "unprognostic (7.32e-2)" "unprognostic (2.60e-3)" "unprognostic (3.68e-2)" "unprognostic (5.69e-2)" "unprognostic (5.09e-2)" "unprognostic (2.78e-2)" 0.0 0.2 0.6 0.0 0.3 0.0 0.0 0.6 5.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 2.3 0.4 3.2 0.0 0.0 0.9 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.2 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 TRPC6 "FSGS2, TRP6" ENSG00000137672 "Transient receptor potential cation channel subfamily C member 6" Q9Y210 11 101451564-101872562 "Disease related genes, Plasma proteins, Potential drug targets, Predicted membrane proteins, Transporters, Voltage-gated ion channels" "Calcium transport, Ion transport, Transport" "Calcium channel, Ion channel" "Disease mutation" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "lung: 35.3;placenta: 20.6" "Cell line enhanced" "Detected in some" "A549: 4.6;ASC diff: 8.6;BJ hTERT+: 4.6;HEL: 4.3;RPTEC TERT1: 20.7" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Cell type enriched" "Detected in some" 5 "eosinophil: 5.5" "Lineage enriched" "Detected in many" 5 "granulocytes: 5.5" "Low region specificity" "Detected in many" "Group enriched" "Detected in many" 4 "cerebral cortex: 7.1;hippocampal formation: 12.5;midbrain: 9.6" HPA045098 Approved 140000 "HPA045098: AB_10959600" "unprognostic (1.45e-1)" "unprognostic (4.21e-1)" "unprognostic (2.43e-1)" "unprognostic (8.71e-5)" "unprognostic (1.86e-1)" "unprognostic (1.36e-2)" "unprognostic (4.33e-2)" "unprognostic (1.14e-1)" "unprognostic (4.30e-2)" "unprognostic (3.04e-1)" "unprognostic (1.98e-2)" "unprognostic (1.30e-1)" "unprognostic (5.47e-4)" "unprognostic (1.99e-3)" "unprognostic (4.88e-2)" "unprognostic (7.16e-2)" "unprognostic (1.32e-2)" 6.0 0.5 1.5 0.6 2.4 0.1 9.7 0.8 2.0 7.6 3.9 1.1 7.5 1.1 6.6 7.0 10.8 5.3 3.2 1.1 2.0 1.5 1.6 0.4 35.3 0.9 2.2 3.4 2.2 1.0 1.0 0.6 20.6 2.9 2.3 1.6 0.3 3.3 7.2 0.8 3.0 1.9 3.9 0.7 2.0 1.5 1.0 0.1 0.1 9.6 2.7 1.1 1.6 3.8 0.0 1.0 5.5 0.5 0.0 0.0 0.3 0.0 4.6 0.2 0.0 8.6 2.1 0.0 3.0 4.6 0.7 0.1 0.2 0.0 0.4 0.0 0.3 0.0 0.0 0.0 0.1 0.0 0.1 4.3 0.0 0.0 0.1 0.0 0.0 2.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 20.7 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.1 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 5.5 0.0 0.2 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.5 1.0 0.0 0.3 1.5 2.4 0.8 2.0 2.0 1.5 2.2 3.4 2.9 0.1 TRPC7 ENSG00000069018 "Transient receptor potential cation channel subfamily C member 7" Q9HCX4 5 136213320-136365545 "Predicted membrane proteins, Voltage-gated ion channels" "Calcium transport, Ion transport, Transport" "Calcium channel, Ion channel" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "adrenal gland: 2.2;brain: 1.6;intestine: 1.3;kidney: 1.5;pituitary gland: 2.2;testis: 2.4" "Cell line enhanced" "Detected in some" "EFO-21: 1.7;SCLC-21H: 1.0" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in many" "Low region specificity" "Detected in some" "CAB022592, HPA031126" Uncertain Uncertain "Actin filaments,Focal adhesion sites" "Focal adhesion sites" "Actin filaments" "CAB022592: , HPA031126: AB_10603221" "unprognostic (1.49e-1)" "unprognostic (2.08e-1)" "unprognostic (3.03e-2)" "unprognostic (2.89e-5)" "unprognostic (3.26e-1)" "unprognostic (2.75e-1)" "unprognostic (9.99e-2)" "unprognostic (1.77e-1)" "unprognostic (6.78e-2)" 0.0 2.2 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.0 0.0 1.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.6 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 2.4 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 1.7 0.0 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 TRPM1 "CSNB1C, LTRPC1, MLSN1" ENSG00000134160 "Transient receptor potential cation channel subfamily M member 1" Q7Z4N2 15 31001061-31161273 "Disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Voltage-gated ion channels" "Ion transport, Sensory transduction, Transport, Vision" "Ion channel, Ligand-gated ion channel, Receptor" "Congenital stationary night blindness, Disease mutation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 9 "retina: 99.0" "Cell line enriched" "Detected in single" 122 "SK-MEL-30: 15.9" "Cancer enriched" "Detected in single" 179 "melanoma: 14.6" "Low region specificity" "Detected in single" "Cell type enhanced" "Detected in single" "naive B-cell: 1.0" "Low lineage specificity" "Detected in single" "Not detected" "Not detected" "Not detected" "Not detected" "HPA014779, HPA071139" Enhanced Uncertain "Golgi apparatus,Plasma membrane,Centriolar satellite" "Centriolar satellite" "Golgi apparatus, Plasma membrane" "HPA014779: , HPA071139: " "unprognostic (5.28e-2)" "unprognostic (1.35e-1)" "unprognostic (9.89e-2)" "unprognostic (3.07e-1)" "unprognostic (1.97e-1)" "unprognostic (1.70e-1)" "unprognostic (1.29e-3)" "unprognostic (2.83e-1)" "unprognostic (2.89e-2)" "unprognostic (1.67e-1)" "unprognostic (1.45e-2)" "unprognostic (2.58e-1)" "unprognostic (7.84e-2)" "unprognostic (6.20e-4)" "unprognostic (1.48e-1)" "unprognostic (2.63e-2)" 0.1 0.0 0.4 0.0 0.6 0.0 0.1 0.1 0.3 0.4 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.7 0.2 0.3 0.1 0.1 0.1 1.6 0.0 0.0 0.0 0.0 0.0 0.1 0.3 0.0 0.0 99.0 0.4 0.0 0.2 10.4 0.0 0.1 1.9 0.0 0.0 2.9 0.1 0.0 0.0 0.0 0.1 0.0 0.0 1.0 0.0 0.3 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 15.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 1.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.1 0.4 0.6 0.1 0.3 0.7 0.2 1.6 0.0 0.3 0.1 TRPM3 "GON-2, KIAA1616, LTRPC3" ENSG00000083067 "Transient receptor potential cation channel subfamily M member 3" Q9HCF6 9 70529063-71446904 "Predicted intracellular proteins, Predicted membrane proteins, Transporters, Voltage-gated ion channels" "Calcium transport, Ion transport, Transport" "Calcium channel, Ion channel" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 8 "brain: 36.6;kidney: 28.0;retina: 105.2" "Cell line enriched" "Detected in some" 4 "HAP1: 19.0" "Cancer enhanced" "Detected in single" "renal cancer: 0.9" "Low region specificity" "Detected in all" "Cell type enriched" "Detected in single" 16 "NK-cell: 2.1" "Lineage enriched" "Detected in single" 16 "NK-cells: 2.1" "Low region specificity" "Detected in all" "HPA072650, HPA074393" Enhanced Approved Vesicles Vesicles "HPA072650: , HPA074393: " "unprognostic (3.74e-1)" "unprognostic (6.30e-2)" "unprognostic (4.79e-2)" "unprognostic (4.81e-2)" "unprognostic (1.38e-2)" "unprognostic (8.88e-2)" "unprognostic (1.49e-2)" "unprognostic (2.19e-2)" "unprognostic (1.11e-1)" "unprognostic (1.89e-2)" "unprognostic (6.10e-2)" "unprognostic (1.15e-2)" "unprognostic (1.82e-7)" "unprognostic (3.51e-2)" "unprognostic (5.64e-2)" "unprognostic (1.74e-2)" "unprognostic (1.50e-2)" 0.9 1.7 6.0 0.7 4.5 1.1 0.8 36.6 5.1 0.8 0.7 9.6 2.1 1.8 2.4 3.0 0.7 1.3 1.3 1.4 9.4 6.0 28.0 0.9 0.8 0.7 8.3 3.5 5.3 1.5 0.7 6.8 0.8 34.8 1.4 0.7 105.2 0.8 5.0 1.1 0.8 0.7 1.0 8.1 1.1 1.6 5.3 5.9 0.0 2.1 0.0 0.6 0.8 0.5 0.0 0.0 0.0 0.0 2.1 0.1 0.0 0.0 0.0 1.0 0.1 1.2 2.9 0.0 0.1 0.0 0.0 0.1 0.1 0.0 0.0 0.1 0.1 0.0 19.0 0.0 0.1 0.0 0.1 0.1 1.5 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.2 0.2 0.0 1.1 4.4 0.0 0.0 0.0 1.3 0.1 0.0 0.2 0.0 0.9 0.0 1.3 0.0 0.2 0.0 0.3 0.0 0.0 3.5 0.0 0.1 3.4 0.0 0.0 0.0 0.0 0.5 0.0 1.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 2.1 0.0 0.0 0.0 0.0 6.0 4.5 36.6 3.8 9.4 6.0 8.3 3.5 34.8 5.9 TRPM4 FLJ20041 ENSG00000130529 "Transient receptor potential cation channel subfamily M member 4" Q8TD43 19 49157741-49211836 "Disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters, Voltage-gated ion channels" "Adaptive immunity, Immunity, Ion transport, Transport" "Calmodulin-binding, Ion channel" "Disease mutation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell line enhanced" "Detected in many" "RT4: 32.5;SK-BR-3: 21.4" "Cancer enhanced" "Detected in all" "prostate cancer: 85.3" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Group enriched" "Detected in many" 5 "dendritic cells: 5.4;granulocytes: 4.9;monocytes: 6.8" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" HPA041169 Enhanced Supported "Nucleoplasm,Plasma membrane" 6500 "Nucleoplasm, Plasma membrane" "HPA041169: " "unprognostic (8.20e-3)" "unprognostic (1.41e-1)" "unprognostic (7.86e-2)" "prognostic favourable (2.88e-7)" "unprognostic (1.62e-2)" "unprognostic (9.78e-2)" "unprognostic (1.77e-2)" "unprognostic (2.90e-1)" "unprognostic (3.33e-2)" "unprognostic (3.38e-2)" "unprognostic (2.94e-2)" "unprognostic (2.79e-1)" "prognostic favourable (2.53e-7)" "unprognostic (8.46e-3)" "unprognostic (2.16e-1)" "unprognostic (5.70e-2)" "unprognostic (1.00e-2)" 6.7 3.8 3.5 13.7 3.7 4.3 8.5 3.0 6.8 8.2 25.2 4.5 8.6 20.6 7.9 9.1 7.7 5.4 24.8 9.3 2.7 2.2 14.2 23.6 9.4 3.5 2.6 5.7 2.7 17.4 3.4 3.3 5.0 6.9 20.2 11.4 10.6 16.2 13.2 16.4 16.1 26.8 9.4 2.5 3.4 18.3 4.2 2.2 0.4 10.1 11.5 6.8 9.9 8.6 1.1 5.4 4.9 6.8 1.0 0.7 2.1 6.0 4.5 1.1 5.1 3.8 3.6 3.6 5.1 3.0 1.4 1.9 3.3 9.5 0.2 1.3 3.4 8.0 0.7 1.5 0.6 0.1 1.6 1.0 1.9 2.0 3.4 0.1 6.6 4.3 7.0 2.6 1.2 2.4 2.4 1.2 3.5 9.1 0.4 0.5 0.6 6.9 2.2 1.0 0.3 2.4 32.5 0.4 1.1 2.1 21.4 1.1 11.6 2.0 6.1 7.6 4.3 4.2 0.1 2.2 2.2 0.2 4.3 4.0 2.8 2.7 6.8 1.1 0.6 4.0 0.5 0.8 0.5 0.4 5.4 1.1 0.6 0.7 4.9 1.0 1.5 4.9 0.3 2.1 3.5 3.7 3.0 6.8 2.7 2.2 2.6 5.7 6.9 2.2 TRPM5 "LTRPC5, MTR1" ENSG00000070985 "Transient receptor potential cation channel subfamily M member 5" Q9NZQ8 11 2404515-2423045 "Predicted membrane proteins, Transporters, Voltage-gated ion channels" "Ion transport, Transport" "Ion channel, Ligand-gated ion channel, Receptor, Voltage-gated channel" "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Tissue enhanced" "Detected in some" "epididymis: 4.1;intestine: 6.3;pancreas: 4.5;seminal vesicle: 4.0" "Cell line enhanced" "Detected in some" "MCF7: 3.2;RPMI-8226: 1.4" "Cancer enhanced" "Detected in some" "pancreatic cancer: 1.8" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA043315 Uncertain "HPA043315: " "unprognostic (1.82e-1)" "unprognostic (1.98e-1)" "unprognostic (6.47e-5)" "unprognostic (6.81e-4)" "unprognostic (7.90e-3)" "unprognostic (1.18e-1)" "unprognostic (1.13e-2)" "unprognostic (2.24e-2)" "unprognostic (4.75e-1)" "unprognostic (1.53e-1)" "unprognostic (2.36e-1)" "unprognostic (3.19e-1)" "unprognostic (5.07e-3)" "unprognostic (2.40e-1)" "unprognostic (5.21e-1)" "unprognostic (5.72e-2)" "unprognostic (4.91e-2)" 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.7 6.1 0.0 4.1 0.0 0.0 0.1 0.0 0.0 0.0 1.5 0.0 0.0 0.0 0.0 0.0 4.5 0.0 0.5 0.0 0.2 0.5 0.0 4.0 0.0 0.0 6.3 0.0 0.0 0.0 0.5 0.9 3.1 0.0 0.2 0.0 0.0 0.1 0.6 0.0 0.0 0.2 0.0 0.0 0.0 0.1 0.3 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.2 0.0 0.1 0.0 0.1 0.0 0.0 1.4 0.0 0.0 0.6 0.0 0.0 0.6 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.5 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.2 0.6 0.0 0.0 0.0 0.0 0.0 TRPM6 "CHAK2, FLJ22628, HOMG, HSH" ENSG00000119121 "Transient receptor potential cation channel subfamily M member 6" Q9BX84 9 74722495-74888094 "Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters, Voltage-gated ion channels" "Calcium transport, Ion transport, Transport" "Calcium channel, Ion channel, Kinase, Serine/threonine-protein kinase, Transferase" "Disease mutation, Primary hypomagnesemia" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "blood: 16.1;intestine: 19.5" "Cell line enhanced" "Detected in some" "BEWO: 7.5;HeLa: 4.4;Karpas-707: 2.5;RT4: 7.2;U-266/70: 2.7" "Cancer enhanced" "Detected in some" "testis cancer: 1.8" "Low region specificity" "Detected in many" "Group enriched" "Detected in some" 6 "basophil: 16.1;neutrophil: 6.6" "Lineage enriched" "Detected in single" 30 "granulocytes: 16.1" "Low region specificity" "Detected in single" "Low region specificity" "Detected in all" "unprognostic (3.95e-2)" "unprognostic (1.46e-1)" "unprognostic (1.76e-1)" "unprognostic (1.65e-1)" "unprognostic (7.80e-2)" "unprognostic (9.20e-2)" "unprognostic (1.59e-2)" "unprognostic (1.72e-1)" "unprognostic (2.82e-1)" "unprognostic (1.84e-1)" "unprognostic (5.72e-4)" "unprognostic (1.58e-1)" "unprognostic (1.71e-2)" "unprognostic (8.10e-2)" "unprognostic (7.54e-2)" "unprognostic (1.89e-2)" "unprognostic (2.11e-2)" 2.9 0.0 1.3 0.5 1.2 2.5 1.1 1.3 1.2 0.8 13.3 0.2 1.0 7.2 0.4 0.2 0.6 0.4 1.0 0.5 1.9 1.2 3.1 0.2 1.5 0.2 2.6 0.0 0.4 0.2 3.8 4.9 0.2 1.6 1.7 17.5 0.4 1.1 0.0 1.6 0.8 19.5 0.7 5.0 3.9 0.2 1.7 0.5 1.6 0.3 1.1 2.1 0.5 0.6 0.3 0.3 16.1 0.1 0.5 0.1 0.0 0.0 1.6 0.2 0.2 0.0 0.0 7.5 0.1 0.0 0.0 0.1 2.1 0.2 0.6 0.0 0.1 0.3 0.5 0.5 0.0 0.1 0.2 0.2 4.4 0.3 0.1 0.1 0.2 0.3 0.2 0.0 0.0 0.2 0.0 2.5 0.1 0.9 0.0 0.1 0.6 0.2 0.0 0.0 0.3 0.0 7.2 0.3 0.0 0.0 0.1 0.1 0.3 0.0 0.0 0.2 1.1 0.2 0.0 2.7 0.0 0.2 0.1 0.1 0.3 16.1 0.1 1.9 0.1 0.1 0.0 0.1 0.1 0.1 0.0 0.3 0.1 0.1 6.6 0.5 0.1 0.3 0.0 0.0 1.3 1.2 1.3 1.2 1.9 1.2 2.6 0.0 1.6 0.5 TRPM7 "CHAK1, LTRPC7, TRP-PLIK" ENSG00000092439 "Transient receptor potential cation channel subfamily M member 7" Q96QT4 15 50552473-50686815 "Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters, Voltage-gated ion channels" "Calcium transport, Ion transport, Necrosis, Transport" "Calcium channel, Ion channel, Kinase, Serine/threonine-protein kinase, Transferase" "Amyotrophic lateral sclerosis, Neurodegeneration, Parkinsonism" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "parathyroid gland: 91.8" "Cell line enhanced" "Detected in all" "U-2197: 49.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA035522, HPA052173" Enhanced Approved "Vesicles,Plasma membrane,Cytosol" "Plasma membrane" "Vesicles, Cytosol" "HPA035522: , HPA052173: " "unprognostic (3.14e-2)" "unprognostic (1.86e-1)" "unprognostic (1.58e-1)" "unprognostic (1.42e-2)" "unprognostic (1.89e-1)" "unprognostic (1.60e-2)" "unprognostic (1.85e-2)" "unprognostic (2.59e-2)" "unprognostic (5.46e-3)" "unprognostic (2.64e-1)" "unprognostic (2.91e-1)" "unprognostic (1.59e-2)" "unprognostic (3.20e-2)" "unprognostic (2.08e-1)" "unprognostic (7.59e-2)" "unprognostic (9.45e-2)" "unprognostic (1.97e-1)" 13.3 10.8 6.6 14.7 9.0 12.8 12.1 19.5 9.3 11.8 11.7 8.1 9.7 9.9 16.5 10.7 9.4 11.0 8.2 19.1 5.5 4.9 16.0 20.0 10.8 10.6 12.4 5.2 16.6 11.6 91.8 14.6 14.3 10.2 9.7 10.3 28.6 11.5 13.5 10.8 11.7 12.8 12.8 9.8 11.1 10.3 6.9 10.0 14.5 12.6 6.9 12.6 12.9 12.3 7.0 4.7 4.4 3.4 5.7 7.6 2.0 8.3 8.3 7.0 7.7 20.2 15.2 8.5 10.6 14.7 6.7 8.9 11.4 4.6 18.2 5.2 12.2 14.1 9.3 7.8 9.7 10.1 5.6 14.5 12.8 6.0 18.4 15.0 11.3 14.1 9.2 7.6 14.4 5.4 16.4 14.0 12.2 13.1 9.6 7.3 5.3 5.1 10.6 9.7 8.9 9.4 19.8 5.8 7.4 7.3 11.6 14.2 7.3 16.3 8.2 10.7 5.1 49.9 12.1 9.5 21.0 17.5 11.7 30.7 9.9 3.8 3.4 3.9 6.6 3.2 7.6 5.6 4.8 4.4 3.7 7.0 4.4 5.2 4.4 5.7 3.2 4.7 4.8 2.0 6.6 9.0 19.5 9.3 5.5 4.9 12.4 5.2 10.2 10.0 TRPM8 ENSG00000144481 "Transient receptor potential cation channel subfamily M member 8" Q7Z2W7 2 233917398-234019522 "FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins, Voltage-gated ion channels" "Ion transport, Sensory transduction, Transport" "Ion channel" "FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 9 "liver: 16.7;prostate: 44.1" "Cell line enhanced" "Detected in some" "Karpas-707: 7.1;RPTEC TERT1: 10.6;SK-MEL-30: 10.6;WM-115: 6.4" "Cancer enriched" "Detected in some" 27 "prostate cancer: 72.4" "Not detected" "Not detected" "Cell type enhanced" "Detected in single" "NK-cell: 3.0" "Low lineage specificity" "Detected in single" "Region enhanced" "Detected in single" "cerebellum: 0.8" "Low region specificity" "Detected in many" "unprognostic (4.41e-3)" "unprognostic (7.91e-2)" "unprognostic (1.11e-1)" "unprognostic (5.49e-3)" "unprognostic (1.05e-1)" "unprognostic (4.60e-3)" "prognostic favourable (7.15e-4)" "unprognostic (3.28e-2)" "unprognostic (3.71e-1)" "unprognostic (9.88e-3)" "unprognostic (7.10e-3)" "unprognostic (4.69e-2)" "unprognostic (3.36e-5)" "unprognostic (1.11e-1)" "unprognostic (1.65e-1)" "unprognostic (1.18e-1)" "unprognostic (5.53e-2)" 3.3 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.4 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 16.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.7 44.1 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.6 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.2 0.9 0.2 3.0 0.3 0.0 0.0 0.7 0.1 0.1 0.0 0.0 1.5 0.0 0.0 0.0 0.3 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 7.1 0.1 0.0 0.0 1.2 0.2 0.0 0.0 0.6 0.7 10.6 0.0 0.7 0.4 0.0 0.1 10.6 0.4 0.7 0.0 0.0 0.1 0.3 0.0 1.5 2.4 0.0 0.9 0.0 6.4 0.5 0.2 0.1 0.3 0.1 0.2 0.2 0.3 0.2 0.0 0.4 0.3 0.3 0.9 3.0 0.1 0.2 0.1 0.0 0.0 0.6 0.0 0.4 0.0 0.1 0.0 0.0 0.7 0.9 TRPV1 VR1 ENSG00000196689 "Transient receptor potential cation channel subfamily V member 1" Q8NER1 17 3565444-3609411 "FDA approved drug targets, Predicted membrane proteins, Transporters, Voltage-gated ion channels" "Calcium transport, Ion transport, Transport" "Calcium channel, Calmodulin-binding, Ion channel" "FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "liver: 11.7" "Cell line enhanced" "Detected in many" "HaCaT: 12.9" "Not detected" "Not detected" "Low cell type specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Not detected" "Not detected" "Low region specificity" "Detected in single" "unprognostic (3.96e-2)" "unprognostic (1.63e-1)" "unprognostic (1.18e-1)" "unprognostic (1.33e-2)" "unprognostic (6.83e-2)" "unprognostic (3.21e-4)" "unprognostic (9.90e-2)" "unprognostic (2.95e-1)" "unprognostic (2.03e-1)" "unprognostic (2.56e-2)" "unprognostic (3.43e-3)" "unprognostic (6.17e-3)" "unprognostic (6.97e-4)" "unprognostic (4.25e-1)" "unprognostic (4.78e-1)" "unprognostic (3.81e-2)" "unprognostic (5.12e-3)" 1.4 1.2 3.5 0.7 2.9 0.3 1.7 2.7 2.1 2.1 1.4 6.5 2.3 1.5 0.8 2.8 1.1 1.9 3.2 3.6 2.5 11.7 0.7 1.3 4.7 5.1 2.5 1.0 2.0 1.2 1.5 1.7 2.1 1.0 2.8 4.7 5.1 0.9 2.3 1.2 2.2 1.2 1.3 0.8 1.2 1.1 1.1 1.4 1.5 0.8 0.5 2.2 0.3 2.9 5.5 4.5 4.9 4.8 4.6 4.0 1.6 2.4 2.6 2.3 1.3 1.6 1.2 2.2 1.8 12.9 2.7 0.9 1.8 7.1 6.6 0.7 2.9 5.5 2.1 0.3 5.6 5.5 3.0 3.7 1.5 0.5 0.3 2.2 1.5 3.7 2.1 1.0 3.0 2.7 6.1 2.9 0.9 2.1 2.6 1.9 4.1 2.3 4.4 2.2 8.2 2.3 1.6 1.1 2.6 4.4 2.2 1.9 1.3 0.5 1.9 2.3 2.3 0.9 0.8 1.5 0.7 0.2 0.9 0.4 0.6 0.2 0.1 1.1 0.8 2.2 1.5 0.5 0.3 1.4 0.2 0.3 TRPV4 "CMT2C, OTRPC4, TRP12, VR-OAC, VRL-2, VROAC" ENSG00000111199 "Transient receptor potential cation channel subfamily V member 4" Q9HBA0 12 109783085-109833401 "Disease related genes, Potential drug targets, Predicted membrane proteins, Voltage-gated ion channels" "Calcium transport, Ion transport, Transport" "Calcium channel, Calmodulin-binding, Ion channel" "Charcot-Marie-Tooth disease, Disease mutation, Dwarfism, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "salivary gland: 32.6" "Cell line enhanced" "Detected in many" "BEWO: 8.9;BJ hTERT+: 9.1;EFO-21: 8.0;HaCaT: 14.5;HUVEC TERT2: 8.3" "Low cancer specificity" "Detected in all" "Region enriched" "Detected in some" 11 "pons and medulla: 15.0" "Cell type enriched" "Detected in single" 7 "classical monocyte: 3.0" "Lineage enriched" "Detected in single" 7 "monocytes: 3.0" "Low region specificity" "Detected in many" "Not detected" "Not detected" HPA007150 Uncertain "HPA007150: AB_1080393" "unprognostic (2.98e-2)" "unprognostic (1.12e-2)" "unprognostic (2.33e-2)" "unprognostic (4.20e-3)" "unprognostic (6.25e-3)" "unprognostic (1.09e-2)" "unprognostic (7.95e-2)" "unprognostic (2.03e-1)" "unprognostic (9.02e-2)" "prognostic unfavourable (8.10e-4)" "unprognostic (1.24e-1)" "unprognostic (1.68e-1)" "prognostic favourable (4.12e-5)" "unprognostic (1.20e-1)" "unprognostic (2.30e-1)" "unprognostic (1.72e-1)" "unprognostic (1.73e-2)" 1.3 0.9 0.3 0.9 0.4 0.1 3.3 0.2 0.6 2.3 0.4 3.2 0.0 0.6 0.8 3.7 9.5 5.6 5.2 1.6 1.3 0.2 11.6 7.8 2.6 1.8 0.2 0.0 0.6 7.1 0.1 4.3 11.1 15.0 6.2 0.3 12.6 32.6 1.4 0.2 6.5 0.3 0.9 0.3 3.5 0.9 0.7 0.1 0.2 0.9 2.6 8.7 2.6 1.7 0.0 0.4 0.0 3.0 0.0 0.0 0.4 2.5 0.1 0.0 0.0 1.9 1.8 8.9 4.2 9.1 1.2 0.5 0.0 6.3 0.0 8.0 5.4 14.5 1.1 0.0 0.3 0.0 2.1 0.0 0.0 3.6 0.7 0.0 0.0 3.3 2.0 3.3 0.0 8.3 0.8 0.0 0.4 5.3 0.0 0.0 1.6 0.2 0.0 0.5 0.0 0.0 5.1 0.0 0.0 0.3 0.6 2.5 1.2 0.4 5.1 0.0 3.6 0.1 0.0 0.1 0.0 0.0 0.0 0.0 4.8 0.0 3.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.3 0.4 0.2 0.6 1.3 0.2 0.2 0.0 15.0 0.1 TRPV5 "CaT2, ECAC1" ENSG00000127412 "Transient receptor potential cation channel subfamily V member 5" Q9NQA5 7 142908101-142933808 "Predicted membrane proteins, Transporters, Voltage-gated ion channels" "Calcium transport, Ion transport, Transport" "Calcium channel, Calmodulin-binding, Ion channel" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 7 "kidney: 26.0" "Cell line enhanced" "Detected in single" "RT4: 1.0" "Not detected" "Not detected" "Low region specificity" "Detected in some" "Cell type enriched" "Detected in single" 5 "neutrophil: 1.2" "Lineage enriched" "Detected in single" 5 "granulocytes: 1.2" "Not detected" "Not detected" "Low region specificity" "Detected in all" HPA063175 Uncertain "HPA063175: " "unprognostic (7.44e-2)" "unprognostic (3.93e-2)" "unprognostic (1.22e-2)" "unprognostic (4.20e-2)" "unprognostic (1.98e-1)" "unprognostic (3.26e-1)" "unprognostic (3.05e-1)" "unprognostic (2.78e-2)" "unprognostic (1.07e-1)" "unprognostic (7.95e-2)" "unprognostic (7.73e-4)" "unprognostic (4.87e-2)" "unprognostic (3.41e-1)" "unprognostic (4.58e-1)" "unprognostic (7.76e-3)" 0.1 0.0 0.8 0.4 0.7 0.5 0.5 0.1 0.8 0.1 0.1 0.1 0.1 0.7 0.1 0.3 0.1 0.1 0.1 0.1 1.1 0.7 26.0 0.1 0.1 0.2 1.6 0.4 0.1 0.3 0.0 0.1 0.1 0.7 0.1 0.0 0.1 0.3 0.1 0.2 0.1 0.1 0.1 3.5 0.2 0.0 0.8 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.0 0.0 1.2 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.1 0.2 0.1 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.6 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.2 0.2 0.1 0.2 0.0 0.0 0.0 1.0 0.0 0.0 0.6 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.8 0.7 0.1 0.5 1.1 0.7 1.6 0.4 0.7 0.1 TRPV6 "CaT1, ECAC2" ENSG00000165125 "Transient receptor potential cation channel subfamily V member 6" Q9H1D0 7 142871203-142885762 "Predicted intracellular proteins, Predicted membrane proteins, Transporters, Voltage-gated ion channels" "Calcium transport, Ion transport, Transport" "Calcium channel, Calmodulin-binding, Ion channel" "Disease mutation" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "pancreas: 26.1;placenta: 65.1;salivary gland: 34.2" "Cell line enhanced" "Detected in some" "BEWO: 5.5;HaCaT: 10.2;RT4: 18.3;SK-BR-3: 13.5;T-47d: 30.1" "Cancer enriched" "Detected in many" 5 "prostate cancer: 16.1" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in some" HPA062864 Approved "HPA062864: " "unprognostic (9.85e-2)" "unprognostic (1.60e-2)" "unprognostic (6.29e-2)" "unprognostic (8.72e-2)" "unprognostic (1.08e-1)" "unprognostic (1.14e-1)" "unprognostic (7.11e-2)" "unprognostic (5.43e-2)" "unprognostic (3.50e-1)" "unprognostic (4.56e-2)" "unprognostic (3.89e-2)" "unprognostic (3.27e-2)" "unprognostic (8.49e-2)" "unprognostic (9.39e-3)" "unprognostic (1.69e-1)" "unprognostic (7.17e-3)" "unprognostic (3.53e-2)" 0.3 0.0 0.3 0.3 0.3 0.0 2.1 0.3 0.3 0.4 1.2 0.3 0.3 4.1 0.3 0.4 1.7 0.1 4.1 0.3 0.3 0.2 2.5 0.6 0.8 0.3 0.8 0.3 0.3 26.1 0.0 0.4 65.1 0.4 12.6 0.0 0.4 34.2 0.7 0.3 3.7 1.0 0.5 2.0 0.3 2.4 0.7 0.3 0.3 0.7 0.6 1.0 0.3 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.5 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 10.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 18.3 1.1 0.0 0.0 13.5 0.3 30.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.3 0.3 0.3 0.3 0.2 0.8 0.3 0.4 0.3