Despite all the challenges in the world, the HPA consortium can look back on a fruitful year with many new features and the inclusion of massive amounts of additional data. Here we will share some of the highlights from the past year.

The launch of the new version 24 of the Human Protein Atlas portal at the HUPO meeting in Dresden in October. This release presented reorganization of the data into 8 new resources displaying vast amounts of protein profiles in cells, tissues and blood including more than 10 million annotated, high-resolution bioimages. 16 new Knowledge Summaries on topics that are of high biological or medical interest were also introduced together with a Pan-Disease Blood Atlas section exploring the protein profiles in 59 diseases, and a new section based on spatial transcriptomics data as part of the brain resource.

Within an initiative from the Knut and Alice Wallenberg Foundation (KAW) to strengthen AI-research in Sweden HPA was awarded 30 MSEK for the continuation of the Human Protein Atlas program and another 270 MSEK was allocated for the Alpha-Cell program. This program at SciLifeLab in Stockholm aims to build AI-based cell and tissue models, partly based on the HPA data resource. We look forward to embarking on this new extraordinary scientific journey by continuing to explore and annotate the human proteome in various ways and to collaborate with international efforts to model cells, tissues and organs.

The interest in the Human Protein Atlas is continuously increasing and this fall the number of monthly visits on the HPA website exceeded 500 000 for the first time.

There are now more than 900 peer-reviewed articles published by the HPA, and we are grateful for all the feed-back from the research community and the tens of thousands of publications citing us.

The HPA consortium wishes all of you a fruitful 2025 in the field of human protein science.