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A complex staining:
Strong, mainly nuclear, but also weaker cytoplasmic somatic staining in subsets of neurons throughout the brain with remarkable differences in the density of the stained cells between regions: high density of immunostained cells are seen in multiple thalamic nuclei, neocortex layer V, amygdala, cerebellar Purkine-cells, nucleus accumbens, preoptic area, multiple brainstem nuclei; only few cells are immunoreactive in the caudate putamen, septum, VDB and hippocampus.
Axonal/diffuse synaptic staining is seen in the ventral pallidum, in the bulbus olfactorius (glomerular-, externa- and internal plexiform layers), substantia nigra. Median eminence, choroid plexus and pia mater exhibit strong immunostaining.
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Positive cells and structuresi
Manually selected location of the protein positivity, observed by immunofluorescence staining in mouse brain.
The Human Protein Atlas project is funded
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