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Metabotropic Glutamate Receptor 1 is a G-protein Coupled Receptor, with predominant RNA and protein expression in various parts of cortex and cerebellum in the brain, among others.
The localization pattern of this immunostaining is complex:
Moderate-strong intensity staining of dense axonal networks is noticed in the VDB, medial septum, piriform cortex, ventral pallidum, BNST nuclei, globus pallidus, anterior hypothalamus (particularly in the suprachiasmatic nucleus), substantia nigra and periaqueductal gray matter.
Strong staining of dendrites is noticed in the neocortex.
Various (weak to strong) intensity diffuse/synaptic-type immunostaining of synaptic fields is noticed throughout the entire brain with the highest intensity in some thalamic nuclei, entorhinal cortex, cerebellar molecular layer.
In addition, moderate-intensity staining of neuronal cell bodies is noticed in the red nucleus of the midbrain and in some cerebellar and medullar nuclei.
Positive cells and structuresi
Manually selected location of the protein positivity, observed by immunofluorescence staining in mouse brain.
The Human Protein Atlas project is funded
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