Brain tissue expression of RET - Mouse brain

MOUSE BRAIN TISSUE

Gene description	Ret proto-oncogene
Mouse gene	ENSMUSG00000030110 (version 92)
Annotation summary	Moderate-strong diffuse-synaptic imunostaining is noticed throughout the entire forebrain. This diffuse-synaptic staining pattern is, however, restricted only to a few nuclei in the brainstem (like to the substantia nigra and periaqueductal gray matter) as well as to the cerebellar molecular layer. In addition, moderate-strong staining of neuronal cell bodies (seemingly associated with the cell membrane, or enriched adjacent to the cell membrane) is noticed in the thalamus, medial geniculate nucleus and cerebellar Purkinje cells. Area postrema exhibits very strong immunoreactivity.
Positive cells and structuresⁱ Manually selected location of the protein positivity, observed by immunofluorescence staining in mouse brain. Read more	Soma and synapse in neurons. Circumventricular organs of ependymal cells.

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Basal ganglia

Cerebellum

Thalamus

	Protein
	Relative fluorescence intensityⁱ Protein expression in mouse brain using immunofluorescence is reported as mean fluorescence intensity . Read more
Mouse brain region	255 0
Olfactory bulb
Anterior olfactory nucleus (aon)
Granule cell layer (gro)
Internal plexiform layer (ipl)
Mitral cell layer (mi)
Glomerular layer (gl)
Rostral migratory stream (rms)
External plexiform layer (epl)
External plexiform layer of the accessory OB (epla)
Granule cell layer of the accessory OB (gra)
Glomerular layer of the accessory OB (gla)
Cerebral cortex
Frontal association cortex (fra)
Motor cortex (m)
Cingulate cortex (cg)
Piriform cortex, L1 (pirl1)
Piriform cortex, L2 (pirl2)
Piriform cortex, L3 (pirl3)
Insular cortex (i)	N/A
Somatosensory cortex (s)	N/A
Retrosplenial granular cortex (rsg)
Parietal association cortex (p)	N/A
Entorhinal cortex (ent)
Visual cortex (v)
Hippocampus
Polymorph layer of the dentate gyrus (podg)
Molecular layer of the dentate gyrus (modg)
Granular dentate gyrus (grdg)
CA1 - oriens layer (ca1or)
CA1 - pyramidal layer (ca1py)
CA1 - radiatum layer (ca1ra)
CA2 - oriens layer (ca2or)
CA2 - pyramidal layer (ca2py)
CA2 - radiatum layer (ca2ra)
CA3 - oriens layer (ca3or)
CA3 - pyramidal layer (ca3py)
CA3 - radiatum layer (ca3ra)
Stratum lucidum (slu)
Lacunosum moleculare (lmol)
Subiculum (sub)
Amygdala
Nucleus of the lateral olfactory tract (lot)	N/A
Basal medial amygdaloid nucleus (bma)	N/A
Basal lateral amygdaloid nucleus (bla)	N/A
Cortical amygdala (aco)
Central amygdala (ce)	N/A
Medial amygdaloid nucleus (mea)	N/A
Basal ganglia
Dorsal tenia tecta (dtt)
Caudate putamen (cpu)
Accumbens nucleus, core (acbc)
Accumbens nucleus, shell (acbsh)
Island of Calleja (icj)
Ventral pallidum (vp)
Medial septum (ms)
Nucleus of the vertical limb of the diagonal band (vdb)	N/A
Lateral septum (ls)
Nucleus of the horizontal limb of the diagonal band (hdb)
Globus pallidus (gp)
Hypothalamus
Dorsal tuberomammillary nucleus (dtm)	N/A
Mammillary nucleus (mn)
Periventricular hypothalamic nucleus (pe)
Supraoptic nucleus (so)	N/A
Tuberal nucleus (tu)	N/A
Ventral tuberomammillary nucleus (vtm)	N/A
Lateral preoptic area (lpo)
Medial preoptic area (mpo)
Suprachiasmatic nucleus (sch)
Paraventricular hypothalamic nucleus (pa)
Anterior hypothalamic area, central (ahc)
Ventral medial hypothalamic nucleus (vmh)
Arcuate nucleus (arc)
Peduncular part of lateral hypothalmus (plh)
Dorsal medial hypothalamic nucleus (dm)
Thalamus
Medial geniculate nucleus (mg)
Parafascicular thalamic nucleus (pf)	N/A
Pregeniculate nucleus (pg)	N/A
Stria terminalis (st)	N/A
Zona incerta (zi)	N/A
Anterodorsal thalamic nucleus (ad)
Reticular thalamic nucleus (rt)	N/A
Vental anterior thalamic nucleus (va)	N/A
Medial habenular nucleus (mhb)	N/A
Laterodorsal thalamic area (ld)
Paraventricular thalamic nucleus (pv)	N/A
Central medial thalamic area (cm)	N/A
Ventral lateral thalamic area (vl)	N/A
Ventral medial thalamic area (vm)
Lateral habenulal nucleus (lhb)	N/A
Ventral posterior thalamus (vpt)
Anterior pretactal nucleus (apt)	N/A
Retromammillary nucleus (rm)	N/A
Midbrain motor
Substantia nigra, reticular (snr)
Periaquaductal grey (pag)
Interpeduncular nucleus (ip)
Mesencephalic retic form (mrt)
Red nucleus (r)
Oculomotor nucleus (3n)
Mesencephalic trigeminal nucleus (me5)	N/A
Ventral tegmental area (vta)
Midbrain behavioral
Substantia nigra, compact (snc)
Dorsal raphe nucleus (dr)
Median raphe nucleus (mnr)
Midbrain sensory
Superior colliculi (sc)
External cortical inferior colliculli (ecic)
Pons
Barrington's nucleus (bar)	N/A
Koelliker-fuse nucleus (kf)	N/A
Motor tregiminal nucleus (5n)
Parabrachial nucleus (pbp)
Principle sensory trigeminal nucleus (pr5)
Locus coeruleus (lc)
Pontine nucleus (pn)	N/A
Vestibular nucleus (ve)
Pontine reticular nucleus, oral (pno)
Lateral lemniscus (ll)
Superior paraolivary nucleus (spo)
Medulla
Nucleus of the solitary tract (sol)
Raphe magnus nucleus (rmg)
Cochlear nucleus (cn)
Lateral paragigantocellular nucleus (lpg)
Raphe pallidus nucleus (rpa)
Facial nucleus (7n)
Hypoglossal nucleus (12n)
Ambiguus nucleus (amb)
External cuneate nucleus (ecu)
Inferior olivary nucleus (io)
Raphe obscures nucleus (rob)
Dorsal motor nucleus of vagus (10n)
Cerebellum
Vestibulocerebellar nucleus (vecb)	N/A
Moleuclar layer of the cerebellum (cemol)
Purkinje layer of the cerebellum (cepur)
Granular layer of the cerebellum (cegr)
Circumventricular organs
Subcommissural organ (sco)	N/A
Subfornical organ (sfo)
Median eminence (me)
Medulla (ap)

Antibodies in assayⁱ The internal antibody ID for the antibody/antibodies available for this specific target, click link for more antibody information.
HPA008495