This week, we explore a fascinating protein that regulates the unfolded protein response (UPR) in eukaryotic cells in an unusual manner - by sensing the accumulation of unfolded proteins in the endoplasmic reticulum (ER) lumen and conveying this information to the nucleus. This is achieved through unconventional splicing of the XBP1 mRNA in the cytoplasm leading to the induction of a transcriptional program in the nucleus. Hence its apt name - Endoplasmic Reticulum to Nucleus Signaling, ERN1...Read more

A recent study published in Nature Communications has unveiled a complex landscape of autoantibodies emerging after SARS-CoV-2 infection. Researchers investigated the development of autoantibodies in a large cohort of healthcare workers and hospitalized COVID-19 patients, tracking their emergence and persistence over a 16-month period...Read more

On November 7th it was announced that Knut and Alice Wallenberg Foundation in an initiative to strengthen AI and life science allocates an additional SEK 600 million to data-driven life science including SEK 270 million for the "AlphaCell" pilot project aiming to build AI based cell models and SEK 30 million to extend the Human Protein Atlas program until the year 2030...Read more

At the HUPO meeting in Dresden, program director Mathias Uhlen and a group of selected researchers presented an overview of the Human Protein Atlas project, with a particular focus on the content of the new version 24...Read more