The JAK – or Janus kinases, are intracellular proteins that transduce signals from cytokine receptors via the JAK-STAT pathway. More specifically the JAK family phosphorylates the receptor and thus activates downstream proteins, including transcription factors called STATs (Signal Transducers and Activators of Transcription). These transcription factors then migrate to the nucleus where they regulate transcription of many genes with diverse function, including cell growth, development and differentiation...Read more