A recent Molecular Systems Biology study used exploratory spatial proteomics to investigate early changes in high-grade serous ovarian cancer, including precursor lesions in the fallopian tube. In this interview by Gustav Ceder, Dr Fabian Coscia and Dr Mihnea-Paul Dragomir discuss how the team moved from spatial proteomics discovery to tissue-based validation using an Atlas Antibodies / Human Protein Atlas antibody against DHCR7...Read more

The multiplex tissue image of this month showcases the spatial expression pattern of acinar cell-regulating basic helix-loop-helix family member a15 (gene: BHLHA15) in exocrine glandular structures of the salivary gland...Read more

In this edition of multiplex tissue image of the month, the expression pattern of ciliogenesis-activating transcription factor FOXJ1 is contrasted with chromatin-regulating protein HMGN3 in fallopian tube...Read more

Glycolysis-associated enzyme pyruvate kinase L/R (gene: PKLR) is here highlighted in specific tubular structures in the kidney using multiplex immunohistochemistry (mIHC/IF)...Read more

In this edition of multiplex tissue image of the month, meiosis-associated BEN domain containing 2 (gene: BEND2) is showcased within developing spermatocytes in testis...Read more