Glioblastoma multiforme (GBM) is one of the most malignant central nervous system tumors, showing a poor prognosis and low survival rate. Therefore, deciphering the underlying molecular mechanisms involved in the progression of the GBM and identifying the key driver genes responsible for the disease progression is crucial for discovering potential diagnostic markers and therapeutic targets...Read more

Elevated expression of the C-type lectin CD93 in the glioblastoma vasculature regulates cytoskeletal rearrangements that enhance vessel function and reduce host survival

CD93 encodes for a cell-surface glycoprotein and is expressed in myeloid cells and endothelial cells. CD93 has recently been identified as an important gene in primary tumor angiogenesis and the corresponding protein has been shown to have proangiogenic properties. In the present study the role of CD93 in malignant glioma was analyzed. The effect on glioblastoma vessels and tumor growth was studied...Read more